MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Diabetes and Its Complications' source. Thu, 05 Jan 2012 11:08:56 +0100 http://www.medworm.com/index.php?rid=5487675&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711001243%2Fabstract%3Frss%3Dyes Abstract: Background: In diabetes, foot ulceration may result from increased skin fragility. Retinoids can reverse some diabetes-induced deficits of skin structure and function, but their clinical utility is limited by skin irritation. The effects of diabetes and MDI 301, a nonirritating synthetic retinoid, and retinoic acid have been evaluated on matrix metalloproteinases (MMPs), procollagen expression, and skin structure in skin biopsies from nondiabetic volunteers and diabetic subjects at risk of foot ulceration using organ culture techniques.Methods: Zymography and enzyme-linked immunosorbent assay were utilized for analysis of MMP-1, -2, and -9 and tissue inhibitor of metalloproteinase-1 (TIMP-1) and immunohistochemistry for type I procollagen protein abundance. Collagen structure par... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5487675 Mon, 07 Nov 2011 05:00:00 +0100 5487675 http://www.medworm.com/index.php?rid=5487669&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711001231%2Fabstract%3Frss%3Dyes Abstract: Background: India is the diabetic capital of the world. Coronary heart disease is a major cause of morbidity and mortality among diabetics. Type 2 diabetes mellitus and atherosclerosis are complex diseases sharing common antecedents like inflammation. High-sensitivity C-reactive protein (hs-CRP), an acute phase reactant protein, is a proinflammatory atherogenic circulating marker which can prove to be an independent cardiac risk predictor.Aim: The aim of the present study was to evaluate the role of hs-CRP as an independent cardiovascular risk marker among Indians with type 2 diabetes with normal lipid profile.Settings and Design: This was a case control study including 60 type 2 diabetics with normal lipid profile and 60 age- and sex-matched healthy controls.Materials and Method... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5487669 Mon, 07 Nov 2011 05:00:00 +0100 5487669 http://www.medworm.com/index.php?rid=5487667&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711001255%2Fabstract%3Frss%3Dyes This report examines predictors of the effect of intensive therapy on the primary outcome in this population.Methods: This trial included 1791 subjects. Baseline cardiovascular risk factors were collected by interview and the VA record. The analyses were done by intention to treat.Findings: Univariate analysis at baseline of predictors of a primary cardiovascular (CV) event included a prior CV event, age, insulin use at baseline, and duration of diagnosed diabetes (all P 1.0) after which the HR is below 1.0. From 7 to 15 years' duration at entry, subjects have HRs favoring intensive treatment. Thereafter the HR approaches 1.0 and over-21-years' duration approaches 2.0. Duration over 21 years resulted in a HR of 1.977 (CI 1.77–3.320, P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5487667 Mon, 07 Nov 2011 05:00:00 +0100 5487667 http://www.medworm.com/index.php?rid=5487666&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711001413%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5487666 Tue, 01 Nov 2011 04:00:00 +0100 5487666 http://www.medworm.com/index.php?rid=5487670&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711001206%2Fabstract%3Frss%3Dyes Conclusions: Low-carbohydrate and low-fat diets both have beneficial effects on CVD markers. There may be different mechanisms through which weight loss with these diets potentially reduces CVD risk. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5487670 Mon, 31 Oct 2011 04:00:00 +0100 5487670 http://www.medworm.com/index.php?rid=5487673&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687271100122X%2Fabstract%3Frss%3Dyes Conclusions: Diabetes self-foot care was significantly better among rural veterans than their urban counterparts, but quality of care was equivalent. This suggests that clinical diabetes care among veterans is uniform; however, greater efforts for patient education and support in diabetes self-management are needed to improve outcomes. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5487673 Mon, 10 Oct 2011 04:00:00 +0100 5487673 http://www.medworm.com/index.php?rid=5487672&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711001218%2Fabstract%3Frss%3Dyes The objective was to assess the proportion of hospitalized patients with diabetes who have a LEA among all hospital patients with diabetes mellitus (DM) and to investigate risk factors for diabetic LEA (especially renal disease and ethnicity) using hospital discharge database.Method: A retrospective study of hospital discharge database (2004–2009) was performed to identify patients with DM, LEA and renal disease using the International Statistical Classification of Diseases and Related Health Problems, Ninth Revision, Australian Modification codes.Results: Of 44 917 hospitalized patients with DM during the 6 years, 7312 (16.3%) patients had renal disease, and 1457 (3.2%) patients had LEA. DM patients with renal disease had significant higher rates of LEA (7.1%) compared to DM patients w... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5487672 Mon, 10 Oct 2011 04:00:00 +0100 5487672 http://www.medworm.com/index.php?rid=5209658&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711001048%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209658 Thu, 01 Sep 2011 04:00:00 +0100 5209658 http://www.medworm.com/index.php?rid=5487674&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000869%2Fabstract%3Frss%3Dyes Abstract: Purpose: The purpose was to assess the activity of nuclear factor (NF)-κB and hypoxia inducible factor (HIF)-1α transcription factors and the expression levels of inflammation markers [interleukin (IL)-6 and IL-8] in the vitreous of patients suffering from proliferative diabetic retinopathy (PDR) scheduled for elective vitreous surgery in a single academic-based retina practice in a prospective clinical study.Methods: Twenty-seven patients with PDR were enrolled in the study. The severity of retinopathy was classified (0, 1, 2, 3, 4) and the activity of neovascularization was graded (0, 1, 2, 3, 4) by the surgeon intraoperatively. Samples of the vitreous were collected during surgery, and the activity of NF-κB and HIF-1α transcription factors and the expression levels of IL-6... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5487674 Wed, 03 Aug 2011 04:00:00 +0100 5487674 http://www.medworm.com/index.php?rid=5487671&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000857%2Fabstract%3Frss%3Dyes Abstract: Increased serum resistin was found in rodent models of obesity and insulin resistance, whereas contradictory results have been obtained in human studies. In humans, resistin is primarily released by monocytes/macrophages, suggesting that soluble levels may be associated with macrophage activation. Here, systemic and monocyte-released resistin levels were found to be similar in type 2 diabetic (T2D) patients, overweight controls and normal-weight controls. When adjusted for body mass index and age, serum resistin modestly correlated with gamma-glutamyltransferase levels, fasting glucose and interleukin-6. Systemic resistin was marginally increased in T2D patients treated with beta-blockers or urate-lowering drugs and was considerably higher in patients treated with loop diuretics.... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5487671 Wed, 03 Aug 2011 04:00:00 +0100 5487671 http://www.medworm.com/index.php?rid=5209669&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000882%2Fabstract%3Frss%3Dyes Abstract: Aims: Although sulfonylurea added to metformin is the first oral drug combination regimen for patients with type 2 diabetes recommended by the American Diabetes Association/European Association for the Study of Diabetes consensus statement, it does not allow for individualizing and optimizing therapy with respect to sustaining glycemic control and the reduction of glucose variability. We therefore sought to investigate acarbose as an alternative to glibenclamide in combination with metformin and compare the effects on metabolic control and glucose variability.Methods: Type 2 diabetic patients 30–70 years of age with glycosylated hemoglobin 7.0%–11.0% while treated with one or two oral antidiabetic drugs were successively enrolled. After 8 weeks of run-in with metformin 500 mg... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209669 Wed, 03 Aug 2011 04:00:00 +0100 5209669 http://www.medworm.com/index.php?rid=5209668&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000870%2Fabstract%3Frss%3Dyes Conclusion: In summary, the PSMD9 gene SNPs studied contribute to the genetic risk of diabetic neuropathy in our Italian data set, showing statistical significance for an additive model-based inheritance. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209668 Wed, 03 Aug 2011 04:00:00 +0100 5209668 http://www.medworm.com/index.php?rid=5209667&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000894%2Fabstract%3Frss%3Dyes Conclusions: Obesity emerged as a significant independent predictor of cardinal symptoms suggestive of gastroparesis in patients with T2DM and neuropathy. This finding suggests that mechanisms in addition to neuropathy play a role in the generation of symptoms suggestive of gastroparesis in this patient population. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209667 Wed, 03 Aug 2011 04:00:00 +0100 5209667 http://www.medworm.com/index.php?rid=5209666&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000900%2Fabstract%3Frss%3Dyes Conclusions: Peripheral sympathetic neuropathy is not likely to be the pathophysiologic mechanism behind the hyperemia in the foot during an acute attack of CA. The hyperemia is more likely secondary to local inflammatory events. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209666 Wed, 03 Aug 2011 04:00:00 +0100 5209666 http://www.medworm.com/index.php?rid=5487676&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000626%2Fabstract%3Frss%3Dyes Comparative studies of vildagliptin and sitagliptin are limited. Although both drugs target dipeptidyl peptidase 4 (DPP-4), pharmacological differences have been described, with sitagliptin having greater potency and selectivity in DPP-4 inhibition per molecule and vildagliptin having a lower proportion of unmetabolized drug excreted in the urine (). In particular, the enzyme inhibitors of human DPP-4, such as sitagliptin and alogliptin, bind to the enzyme to form a DPP-4/inhibitor complex. However, vildagliptin is not strictly a DPP-4 inhibitor. It is a slow substrate of DPP-4, displaying tight-binding kinetics with very slow dissociation rates compared with GLP-1: the vildagliptin/DPP-4 complex dissociates slowly, giving a long duration of inhibition and excellent in vivo potency due to ... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5487676 Wed, 20 Jul 2011 04:00:00 +0100 5487676 http://www.medworm.com/index.php?rid=5487668&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000614%2Fabstract%3Frss%3Dyes Conclusions: In diabetic adults with no cardiovascular disease events, A1c was negatively associated with ability to achieve LDL-C, non-HDL-C and SBP goals but was not independently related to treatment-associated changes in CIMT or LVMI over 36 months. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5487668 Wed, 20 Jul 2011 04:00:00 +0100 5487668 http://www.medworm.com/index.php?rid=4999745&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000699%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4999745 Thu, 30 Jun 2011 23:00:00 +0100 4999745 http://www.medworm.com/index.php?rid=5209660&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000390%2Fabstract%3Frss%3Dyes Conclusion: Reaching strict glycemic control levels in the general US population with type 2 diabetes appears to be associated with lower mortality. Further research is needed as to how strict glycemic control affects certain diabetic groups. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209660 Thu, 09 Jun 2011 04:00:00 +0100 5209660 http://www.medworm.com/index.php?rid=4999757&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000407%2Fabstract%3Frss%3Dyes Abstract: Problem: Insulin analogues are increasingly used in patients with type 2 diabetes. We performed a systematic review of randomized controlled trials (RCTs) to assess the role of insulin analogues to reach different hemoglobin A1c (HbA1c) targets (from 6.5% to 8%) in type 2 diabetic patients.Methods: RCTs involving insulin regimens (basal, prandial, biphasic, and basal-bolus) with insulin analogues in type 2 diabetes were identified through electronic searches (MEDLINE, EMBASE, CINAHL, and The Cochrane Library) through August 2010. We included any study arm of RCTs if they were at least 12 weeks in duration, and reported HbA1c as an outcome and the proportion of diabetic patients reaching the HbA1c target of (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4999757 Tue, 24 May 2011 23:00:00 +0100 4999757 http://www.medworm.com/index.php?rid=4999753&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000365%2Fabstract%3Frss%3Dyes Conclusion: The prevalence of depression among Jordanian subjects with type 1 and type 2 diabetes is high compared with some developed countries. This was associated with gender, educational level, insulin treatment, low self-management behaviors and increased barriers to adherence. This result shows the urgent need to include the routine screening of depression during outpatient visit, which might help prevention, early detection and management of depression. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4999753 Tue, 24 May 2011 23:00:00 +0100 4999753 http://www.medworm.com/index.php?rid=4999752&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000377%2Fabstract%3Frss%3Dyes Abstract: Aims: Using psychological and quality of life assessment tools, we prospectively studied changes in health-related quality of life and emotional well-being in patients who had commenced GLP-1 analogue therapy (exenatide) and compared them with new insulin starters.Methods: Two matched groups of patients with type 2 diabetes who had suboptimal glycaemic control on oral medication were assessed using a battery of well-validated psychological and quality of life tests at baseline, prior to commencement of treatment and then again after 6 months of continuous therapy, along with body mass index (BMI) and hemoglobin A1c (HbA1c) measurements.Results: In the exenatide-treated patient group (n=71), treatment satisfaction was greater (P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4999752 Tue, 24 May 2011 23:00:00 +0100 4999752 http://www.medworm.com/index.php?rid=4999751&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000389%2Fabstract%3Frss%3Dyes Abstract: Statements of the Problem: Correction of anemia in type 2 diabetes (T2DM) patients with chronic kidney disease stages 3–4 may slow the decline of kidney function but may increase cardiovascular risk through higher hematocrit. The NEPHRODIAB2 study was designed to assess efficacy and safety of complete hemoglobin (Hb) normalization in these patients.Methods: We randomly assigned 89 T2DM patients with an estimated glomerular filtration rate (eGFR; abbreviated 175 Modification of Diet in Renal Disease formula) of 25 to 60 ml/min per 1.73 m2 and moderate anemia (Hb, 100–129 g/l) to a target Hb value in subnormal range (110–129g/l, group 1, n=43) or normal range (130–149 g/l, group 2, n=46). The primary end point was eGFR decline after 2 years of follow-up. Secondary end point... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4999751 Tue, 24 May 2011 23:00:00 +0100 4999751 http://www.medworm.com/index.php?rid=4999750&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000419%2Fabstract%3Frss%3Dyes Abstract: Aim: The aims of this study were to determine the prevalence of hypertension in type 1 diabetes patients and to analyze its relationship with insulin resistance and other associated factors.Design and Methods: A cross-sectional study on 291 patients with type 1 immune-mediated diabetes managed at two outpatient endocrinology clinics was performed. All participants were Caucasian, 18 years or older with type 1 diabetes duration of more than 6 months, who had completed the study protocol. Hypertension was defined as blood pressure ≥130/80 mmHg or use of antihypertensive medication, excluding angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers when used as treatment for micro- or macroalbuminuria.Results: Hypertension was found in 87 [29.9% (95% confidence... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4999750 Tue, 24 May 2011 23:00:00 +0100 4999750 http://www.medworm.com/index.php?rid=4726136&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687271100050X%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4726136 Tue, 19 Apr 2011 17:01:32 +0100 4726136 http://www.medworm.com/index.php?rid=4999756&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687271100033X%2Fabstract%3Frss%3Dyes Abstract: A considerable amount of clinical and experimental evidence now exists and suggests the involvement of fatty acids and free radical-mediated oxidative processes in the pathogenesis of diabetic complications. Fetuses from diabetic mothers are at increased risk of developing neonatal macrosomia and oxidative stress. We investigated the modulation of antioxidant status and liver biochemical parameters in normal and diabetic pregnant rats and their offspring. Animals were randomly allocated into three groups of six rats each: a control group, a diabetic group and diabetic rats fed with flax and sesame seeds mixture group. The time course of changes in lipid metabolism and antioxidant status by dietary rich in ω3- and ω6-polyunsaturated fatty acids in alloxan-induced diabetic pregna... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4999756 Thu, 31 Mar 2011 23:00:00 +0100 4999756 http://www.medworm.com/index.php?rid=4999747&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000353%2Fabstract%3Frss%3Dyes Abstract: Controversial data suggest that patients with type 2 diabetes mellitus have an increased risk of fractures despite having, in some studies, higher bone mineral density.Methods: The aim of this study was to determine the prevalence of osteoporosis and morphometric vertebral fractures in 148 postmenopausal diabetic women, aged 61.87±7.85 years, and their relationship with clinical and metabolic factors and chronic complications of the disease.Results: The prevalence of osteoporosis was 30.4% at lumbar spine (LS) and 9.5% at femoral neck (FN). The prevalence of vertebral fractures was 23%, mostly mild and located at the thoracic spine. Patients with fractures were older (P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4999747 Thu, 31 Mar 2011 23:00:00 +0100 4999747 http://www.medworm.com/index.php?rid=4999749&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000328%2Fabstract%3Frss%3Dyes Conclusion: Aggressive efforts at salvage with PF/M amputation procedures should be entertained prior to higher level amputations due to the increased morbidity and mortality evidenced. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4999749 Tue, 29 Mar 2011 23:00:00 +0100 4999749 http://www.medworm.com/index.php?rid=4999754&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000341%2Fabstract%3Frss%3Dyes Conclusions: Comprehensive ophthalmologic assessment of the progression of diabetic retinopathy in patients with type 2 DM may be an indicator of heart muscle perfusion disturbance. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4999754 Fri, 25 Mar 2011 00:00:00 +0100 4999754 http://www.medworm.com/index.php?rid=5209672&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687271100002X%2Fabstract%3Frss%3Dyes We report an uncommon case of an insulin-treated diabetic patient, presenting severe hypoglycemia, coma, marked sinus bradycardia and QT prolongation. Intravenous administration of glucose and atropine awaked the patient and increased heart rate but did not affect QT prolongation. Basal and exercise electrocardiogram excluded primary diseases associated with QT prolongation. Pathophysiologic aspects of electrocardiographic and clinical findings occurring in the hypoglycemic patients are briefly discussed. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209672 Wed, 23 Mar 2011 04:00:00 +0100 5209672 http://www.medworm.com/index.php?rid=5209659&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000031%2Fabstract%3Frss%3Dyes Conclusions: Considerable effort was required to maintain optimal A1C levels in older patients with type 2 diabetes. Since the full benefit of insulin therapy is attained only when multiple components of insulin dosage are frequently adjusted and given the growing shortage of care providers' availability, innovative approaches are needed to empower patients to safely make their own insulin adjustments. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209659 Wed, 02 Mar 2011 05:00:00 +0100 5209659 http://www.medworm.com/index.php?rid=4999755&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000043%2Fabstract%3Frss%3Dyes Conclusion: Acarbose was more effective than placebo in improving glycemic and lipid profile and in reducing the post-OFL peaks of the various parameters including the insulin resistance biomarkers. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4999755 Wed, 02 Mar 2011 00:00:00 +0100 4999755 http://www.medworm.com/index.php?rid=4595891&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872711000134%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4595891 Tue, 01 Mar 2011 00:00:00 +0100 4595891 http://www.medworm.com/index.php?rid=5209673&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710001509%2Fabstract%3Frss%3Dyes Postprandial hyperglycemia is considered an independent risk factor for cardiovascular disease (). Postprandial glucose spikes lead to labile nonenzymatic glycation, oxidative stress and, subsequently, endothelial dysfunction (). Therefore, in daily clinical practice, it is clinically desirable to use an antidiabetic drug strategy which effectively corrects not only the fasting plasma glucose, but also the postprandial glucose excursions. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209673 Mon, 21 Feb 2011 05:00:00 +0100 5209673 http://www.medworm.com/index.php?rid=5209661&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710001510%2Fabstract%3Frss%3Dyes Conclusions: The nomogram could help in ranking the type 2 diabetic patients at higher risk to develop DR and thus with a need for more frequent ophthalmologic checks, without enhancing neither the time nor the costs. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209661 Mon, 21 Feb 2011 05:00:00 +0100 5209661 http://www.medworm.com/index.php?rid=5209663&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710001200%2Fabstract%3Frss%3Dyes Conclusions: Our study suggests that candidate gene polymorphism –629C>A of CETP may serve as a susceptibility biomarker for CVD in T2DM patients. Analyzing the combined effect of both ACE and CETP genotypes would enhance the sensitivity and specificity of CVD risk estimation in the T2DM patients in our population. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209663 Fri, 24 Dec 2010 05:00:00 +0100 5209663 http://www.medworm.com/index.php?rid=4999748&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710001212%2Fabstract%3Frss%3Dyes Conclusions: As only 35% of the patients in this study were referred for eye exams, patients at risk for retinopathy are missing opportunities for screening and early treatment. With the increasing number of children with type 2 DM, more patients will be at risk for retinopathy and its consequences. Pediatricians and endocrinologists should be educated about referring for annual eye exams. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4999748 Thu, 23 Dec 2010 00:00:00 +0100 4999748 http://www.medworm.com/index.php?rid=4254522&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710001340%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4254522 Tue, 14 Dec 2010 00:52:40 +0100 4254522 http://www.medworm.com/index.php?rid=5209665&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000991%2Fabstract%3Frss%3Dyes Conclusions: The PREDIAN study will provide evidence on the renoprotective benefit of PTF in addition to interventions of proven efficacy (RAS blockade) in DN. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209665 Thu, 09 Dec 2010 05:00:00 +0100 5209665 http://www.medworm.com/index.php?rid=5209664&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710001005%2Fabstract%3Frss%3Dyes Abstract: Aims: To determine the relationship between serum uric acid, metabolic syndrome (MetS), and albuminuria in type 2 diabetic patients.Methods: A total of 504 Korean patients with type 2 diabetes aged 57.3 years were retrospectively evaluated for clinical histories, anthropometric measurements, and biochemical studies. Urinary albumin excretion (UAE) was measured by a 24-h urine collection.Results: Prevalence of MetS increased according to the quartiles of uric acid levels (≤3.7, 3.8 to 4.5, 4.6 to 5.5, and >5.5 mg/dl; 52.1%, 52.1%, 57.5%, and 71.6%, respectively, P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209664 Fri, 03 Dec 2010 05:00:00 +0100 5209664 http://www.medworm.com/index.php?rid=5209671&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687271000098X%2Fabstract%3Frss%3Dyes We describe a case of pyomyositis, a potentially severe but uncommon complication of poorly controlled diabetes that was not recognised in the community. Clinicians looking after people with diabetes need to be aware that prolonged, unexplained symptoms need specialist assessment. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209671 Wed, 24 Nov 2010 05:00:00 +0100 5209671 http://www.medworm.com/index.php?rid=5209670&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000978%2Fabstract%3Frss%3Dyes This study aims to examine the effects of flax and pumpkin powder seed mixture on alloxan induced diabetes in Wistar rats. Animals were allocated into three groups of six rats each: a control group (CD), diabetic group (DD) and diabetic rats fed with flax and pumpkin seed mixture (DMS) group. The diabetic rats (DD) presented a significant increase in glycemia, plasma and liver lipid parameters such as total lipid, total cholesterol and triglycerides compared to the control group (CD). In addition, plasma and liver malonaldialdehyde levels (MDA, an index of lipid peroxidation) significantly increased compared to (CD). Antioxidant enzymes activities such as catalase, superoxide dismutase, and reduced glutathione (GSH) levels significantly decreased in the plasma and liver of diabetic rats co... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209670 Wed, 24 Nov 2010 05:00:00 +0100 5209670 http://www.medworm.com/index.php?rid=5209662&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710001029%2Fabstract%3Frss%3Dyes Abstract: Purpose: To evaluate the effect of glucose regulation on intravitreal ranibizumab injection for clinically significant diabetic macular edema (DME).Methods: This retrospective study enrolled 65 eyes of 65 patients with persistent DME treated with intravitreal ranibizumab injection. The main outcome measures were the change in best corrected visual acuity (BCVA), the central subfield macular thickness (CSMT) recorded with optical coherence tomography (OCT), and its correlation with the serum hemoglobin A1c values (HbA1c).Results: The study included 24 (36.9%) female and 41 (63.1%) male patients with a mean age of 58.90±9.45 years. The mean HbA1c of the enrolled patients was 8.25±1.74% (range 5.7–12.7%). The median value of BCVA at baseline examination was 20/80 (52 letters), a... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=5209662 Mon, 15 Nov 2010 05:00:00 +0100 5209662 http://www.medworm.com/index.php?rid=4999746&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710001017%2Fabstract%3Frss%3Dyes Abstract: Aims: To determine whether continuous subcutaneous insulin infusion (CSII) or multiple daily injections of insulin (MDI) are associated with improved glycemic variability.Methods: Type 2 diabetic patients ≥60 years of age were randomized to 12 months of CSII (n=53) or MDI (n=54) therapy. Patients were asked to complete monthly eight-point self-monitored glucose profiles (n=78) and continuous glucose monitoring systems (CGMS) for up to 72 h at Months 0, 6, and 12 (n=77). Within-day mean glucose, standard deviation (SD), range, pre- and post-prandial glucose, M value, and mean amplitude of glycemic excursions (MAGE) were calculated from eight-point profiles. Mean glucose, SD, range, area under the curve (AUC) high (>180 mg/dl) and AUC-low ( (Source: Journal of Diabetes and Its Co... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4999746 Wed, 10 Nov 2010 00:00:00 +0100 4999746 http://www.medworm.com/index.php?rid=4090226&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710001078%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4090226 Sun, 24 Oct 2010 01:37:14 +0100 4090226 http://www.medworm.com/index.php?rid=4595897&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000760%2Fabstract%3Frss%3Dyes Abstract: Substantial evidence supports a genetic susceptibility to develop nephropathy in type 1 diabetes and a key pathogenic role of actin cytoskeleton dysfunction in this complication. We previously reported that many cytoskeletal proteins were either up- or down-regulated in fibroblast cells from type 1 diabetic (T1DM) patients with nephropathy. The gene of one of these proteins, caldesmon, lies in a chromosomal region linked to nephropathy and its promoter region contains a single nucleotide polymorphism that is associated with nephropathy. Hence, we analyzed caldesmon gene and protein expression in cultured fibroblasts from T1DM patients with and without nephropathy and from control subjects. Caldesmon gene was studied in cells cultured under normal glucose levels by quantitative re... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4595897 Mon, 30 Aug 2010 00:00:00 +0100 4595897 http://www.medworm.com/index.php?rid=4726144&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000759%2Fabstract%3Frss%3Dyes Abstract: Aim: Both hyperglycemia and hyperlipidemia increase oxidative stress and contribute to the development of diabetic nephropathy (DN). We investigated the effects of α-lipoic acid, a natural antioxidant and a cofactor in the multienzyme complexes, on the development of DN in diabetic apolipoprotein E-deficient mice.Methods: Twelve-week-old male apoE−/− mice on C57BL/6J genetic background were made diabetic with injections of streptozotocin (STZ). STZ-treated diabetic apoE−/− mice and non-diabetic control were fed with a synthetic high-fat (HF) diet with or without lipoic acid (LA) supplementation. Multiple parameters including plasma glucose, cholesterol, oxidative stress markers, cytokines, and kidney cortex gene expression, and glomerular morphology were evaluated.Result... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4726144 Sun, 29 Aug 2010 23:00:00 +0100 4726144 http://www.medworm.com/index.php?rid=4726143&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000747%2Fabstract%3Frss%3Dyes Conclusion: The cross-linking in DB collagen molecules and the decreased and defective crystallinity in the inorganic portion of DBs might be the reasons for the increased risk of fracture among diabetic patients. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4726143 Sun, 29 Aug 2010 23:00:00 +0100 4726143 http://www.medworm.com/index.php?rid=4726142&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000723%2Fabstract%3Frss%3Dyes This study was designed to evaluate the possible protective role of salivary factors like salivary flow rate and adequate level of calcium, phosphate, and fluoride in diabetes mellitus type 2 patients with dental caries. A total of 398 diabetes mellitus type 2 patients with dental caries and 395 age- and sex-matched non-diabetic subjects with dental caries were included as controls, all of whom gave informed consent. All subjects were divided into four groups according to their age. Decayed, missed, and filled teeth (DMFT) were scored to indicate the severity of dental caries. Saliva was collected, flow rate was noted, and calcium, phosphate, and fluoride were analyzed. The blood glucose, HbA1c, and DMFT indices were found to be significantly high in diabetic patients as compared to contro... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4726142 Sun, 29 Aug 2010 23:00:00 +0100 4726142 http://www.medworm.com/index.php?rid=4726141&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000735%2Fabstract%3Frss%3Dyes Conclusions: Diagnosed depression is associated with a 33% higher risk of incident major lower limb amputation in veterans with diabetes. Further study is needed to understand this relationship and to determine whether depression screening and treatment in patients with diabetes could decrease amputation rates. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4726141 Sun, 29 Aug 2010 23:00:00 +0100 4726141 http://www.medworm.com/index.php?rid=4726138&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000711%2Fabstract%3Frss%3Dyes This study was conducted to determine short-term efficacy and safety of INT131 besylate in patients with Type 2 diabetes mellitus (T2DM).Research Design and Methods: This was a 4-week randomized, double-blind, placebo-controlled multi-center study with 1 or 10mg INT131 besylate or placebo daily in subjects with T2DM not receiving pharmacotherapy for their hyperglycemia. The primary efficacy analysis was the comparison of treatment groups with respect to least square mean change from baseline to Week 4 of fasting plasma glucose (FPG).Results: Baseline mean (±S.D.) FPG for the study population was 171±42 mg/dl. Change in FPG (±S.E., mg/dl) from baseline after 4 weeks was 8±8 (P=NS) with placebo, -22±8 with 1mg INT131 besylate (P=.0056) and −46±7 with 10mg INT131 besylate (P (Source: ... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4726138 Wed, 25 Aug 2010 23:00:00 +0100 4726138 http://www.medworm.com/index.php?rid=4726146&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687271000067X%2Fabstract%3Frss%3Dyes We describe a case of two autoimmune conditions—type 1 diabetes and Graves' disease—being diagnosed for the first time in the same individual at the same visit to the emergency department. We suggest that thyrotoxicosis be added to the list of potential precipitants for diabetic ketoacidosis. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4726146 Thu, 12 Aug 2010 23:00:00 +0100 4726146 http://www.medworm.com/index.php?rid=4726139&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000668%2Fabstract%3Frss%3Dyes Conclusions: CAN is common in diabetes and is associated with modifiable factors including central fat distribution, hypertension, dyslipidemia, worse diabetes control, and smoking, and with the other microvascular complications of diabetes. Our findings emphasize the need for a multifactorial intervention for the prevention of CAN. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4726139 Thu, 12 Aug 2010 23:00:00 +0100 4726139 http://www.medworm.com/index.php?rid=4726137&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000681%2Fabstract%3Frss%3Dyes This study investigated the impact of the publicized safety warnings on glycemic outcomes in patients with diabetes mellitus (DM).Materials and Methods: The Veterans Integrated Services Network 16 database included 13,293 DM patients using TZDs (n=13,037 rosiglitazone, n=246 pioglitazone, n=10 both) during a baseline period of 03/01/07 to 05/31/07. Three medication use patterns groups (09/01/07 to 11/30/07) were defined as follows: (1) continuation on TZD treatment, (2) switching to other non-TZD treatment, (3) discontinuation of TZD treatment without any antidiabetic treatment. Primary outcome (09/01/07 to 02/29/08) was change from baseline in A1c. The analysis of variance was used to test the association between use patterns and A1c change. A logistic regression model was used to identif... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4726137 Thu, 12 Aug 2010 23:00:00 +0100 4726137 http://www.medworm.com/index.php?rid=4726140&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687271000070X%2Fabstract%3Frss%3Dyes Abstract: Problem: Advanced glycation end products (AGEs) and the interaction with their receptors (RAGE) play an important role in the pathogenesis of diabetic retinopathy (DR). Our study investigated whether serum soluble (s) RAGE (sRAGE) could serve as a prognostic tool for identifying the susceptibility to DR. Moreover, we examined the association between soluble forms of vascular cell adhesion molecules (sVCAM-1), nitric oxide (NO) and sRAGE levels in serum and the severity of DR.Methods: Circulating levels of sRAGE, sVCAM-1, and NO were examined in 37 type 2 diabetic patient and 20 age-matched healthy nondiabetic subjects using ELISA. The diabetic subjects were categorized as patients without retinopathy, patients with nonproliferative DR (NPDR), and patients with proliferative DR (P... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4726140 Wed, 04 Aug 2010 23:00:00 +0100 4726140 http://www.medworm.com/index.php?rid=4595900&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000656%2Fabstract%3Frss%3Dyes Abstract: Cystic fibrosis (CF) is one of the most common genetically inherited diseases and often complicated by diabetes mellitus. With increasing longevity, the incidence and prevalence of cystic fibrosis-related diabetes (CFRD) rise and microvascular complications develop. CFRD is an entity on its own with characteristics seen in both type 1 and type 2 diabetes. Keto-acidosis, a potentially life-threatening complication of diabetes, is an extremely rare presentation of CFRD.Here we present the history of a 21-year-old CF patient with no prior diagnosis of CFRD who developed keto-acidosis after an episode of pulmonary infection.Based on this case report we would like to emphasize the importance of screening for and early treatment of CFRD. We also discuss the management policy of CFRD an... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4595900 Mon, 26 Jul 2010 00:00:00 +0100 4595900 http://www.medworm.com/index.php?rid=3922403&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000693%2Fabstract%3Frss%3Dyes Conclusions: As is the case in Western countries, Asian people with diabetes have a higher risk of incident cancer than those without diabetes. Cancer prevention and early detection should be important components of diabetes management in light of the exponentially increasing prevalence of diabetes, which has substantial implications in public health and clinical practices. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3922403 Sun, 25 Jul 2010 23:00:00 +0100 3922403 http://www.medworm.com/index.php?rid=4595894&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000644%2Fabstract%3Frss%3Dyes Conclusions: In this nationwide study, we found the stroke risk in the diabetic population to be still significantly increased compared to the non-diabetic population. The risk increase seems to be as high as earlier observations in other countries, despite large efforts to improve diabetes care. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4595894 Mon, 12 Jul 2010 00:00:00 +0100 4595894 http://www.medworm.com/index.php?rid=4595893&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000498%2Fabstract%3Frss%3Dyes Conclusions: Bedtime plasma glucose level can serve as a predictor of the outcome of long-term blood glucose control during Mix 50 TID monotherapy and that bedtime plasma glucose level needs to be reduced sufficiently to achieve adequate blood glucose control. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4595893 Wed, 23 Jun 2010 00:00:00 +0100 4595893 http://www.medworm.com/index.php?rid=4595896&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000449%2Fabstract%3Frss%3Dyes Conclusions: Adherence to recommended clinical preventive services is under desirable levels among Spanish diabetes sufferers. These preventive services are provided neither equitably nor efficiently, since subjects with unhealthier lifestyles are less likely to receive them. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4595896 Wed, 16 Jun 2010 00:00:00 +0100 4595896 http://www.medworm.com/index.php?rid=3637768&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000528%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3637768 Tue, 08 Jun 2010 13:13:21 +0100 3637768 http://www.medworm.com/index.php?rid=4595892&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000401%2Fabstract%3Frss%3Dyes Abstract: Immune complexes containing modified LDL (LDL-IC) and NMR-determined Total LDL particle concentrations are significantly associated with intima-media thickness (IMT). We analyzed the associations between concentrations of NMR-determined lipoprotein subclasses and LDL-IC in the DCCT/EDIC cohort. LDL-IC concentrations in women and men of the DCCT/EDIC cohort did not differ significantly and were positively associated with Total LDL particle concentrations in men and women (r=0.34, r=0.32, respectively; P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4595892 Fri, 04 Jun 2010 00:00:00 +0100 4595892 http://www.medworm.com/index.php?rid=4595895&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000437%2Fabstract%3Frss%3Dyes Conclusion: Peripheral neuropathy was common in this representative type 2 diabetes population. Clinical signs of PAN were the most frequent followed by diminished perception of vibration and touch. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4595895 Thu, 20 May 2010 00:00:00 +0100 4595895 http://www.medworm.com/index.php?rid=4595899&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000425%2Fabstract%3Frss%3Dyes Abstract: Erectile dysfunction (ED) is defined as the inability of the male to attain and maintain erection of penis sufficient to permit satisfactory sexual intercourse. Prevalence of impotence in diabetic men is ≥50%. The pathophysiology of diabetes-induced erectile dysfunction (DIED) is multifactorial and no single etiology is at the forefront. The proposed mechanisms of erectile dysfunction in diabetic patients includes elevated advanced glycation end-products, increased levels of oxygen free radicals, impaired nitric oxide synthesis, increased endothelin B receptor binding sites and up-regulated RhoA/Rho-kinase pathway, neuropathic damage and impaired cyclic guanosine monophosphate (cGMP)-dependent protein kinase-1. The treatment of DIED is multimodal. Treatment of the underlying hy... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4595899 Wed, 12 May 2010 00:00:00 +0100 4595899 http://www.medworm.com/index.php?rid=4726145&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000413%2Fabstract%3Frss%3Dyes Abstract: Epidemiologic data indicate a continuous relationship between hemoglobin A1c (HbA1c) and risk for microvascular and macrovascular complications of diabetes. Intensive glycemic control reduces risk of microvascular complications in Type 1 and Type 2 diabetes, and long-term treatment and follow-up studies have shown that initial intensive control is associated with reduced cardiovascular risk. Recent intervention trials in older, high-risk patients with Type 2 diabetes have not shown a benefit of intensive control in reducing cardiovascular risk over a rather short-term follow-up period of up to 5 years, with some data indicating that intensive control accompanied by hypoglycemia is detrimental in patients with high cardiovascular risk. Indeed, hypoglycemia with current antidiabeti... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4726145 Tue, 11 May 2010 23:00:00 +0100 4726145 http://www.medworm.com/index.php?rid=3505980&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000322%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3505980 Tue, 27 Apr 2010 13:18:07 +0100 3505980 http://www.medworm.com/index.php?rid=4090235&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000206%2Fabstract%3Frss%3Dyes Conclusion: NADPH oxidase expression is increased in diabetic rat aorta. NADPH oxidase-mediated oxidative stress is accompanied by the decreased eNOS and increased iNOS expressions, contributing to endothelial dysfunction. Apocynin effectively prevents the increased NADPH oxidase expression in diabetic aorta and restores the alterations in NOS expression, blocking the vicious cycle leading to diabetes-associated endothelial dysfunction. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4090235 Fri, 12 Mar 2010 00:00:00 +0100 4090235 http://www.medworm.com/index.php?rid=4595898&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000024%2Fabstract%3Frss%3Dyes Abstract: Introduction: Hyperglycaemia at the time of acute myocardial infarction (AMI) is a predictor of survival and is associated with increased mortality and morbidity in patients with or without diabetes mellitus. On the other hand, insulin has been shown to reduce myocardial injury in experimental studies but its benefits have not been confirmed in clinical studies.Methods: The isolated perfused heart model was used to examine the direct effect of incremental doses of insulin and varying degrees of hyperglycaemia on infarct size and cardiomyocyte apoptosis in rabbit hearts. The rabbit hearts were subjected to 30-min ischaemia and 2.5-h reperfusion.Results: Insulin, given alone just before reperfusion, dramatically reduced infarct size in a dose-dependent manner (75–300 μU/ml) duri... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4595898 Mon, 08 Mar 2010 00:00:00 +0100 4595898 http://www.medworm.com/index.php?rid=4090229&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000036%2Fabstract%3Frss%3Dyes Conclusions: Among patients with Type 2 diabetes, no evidence was found that switch to insulin therapy with or without tightened glycaemic control decreased their high annual risk of antibiotic-treated UTI episodes. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4090229 Tue, 02 Mar 2010 00:00:00 +0100 4090229 http://www.medworm.com/index.php?rid=3308563&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000127%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308563 Fri, 26 Feb 2010 14:12:56 +0100 3308563 http://www.medworm.com/index.php?rid=4254524&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709001329%2Fabstract%3Frss%3Dyes Conclusion: HbA1c was significantly associated with carotid plaque and PAD, but not CCA-IMT and baPWV in Korean type 2 diabetic patients. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4254524 Thu, 28 Jan 2010 00:00:00 +0100 4254524 http://www.medworm.com/index.php?rid=4254527&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709001330%2Fabstract%3Frss%3Dyes Conclusions: Mutation H63D in the HFE gene was associated with a higher risk of type 2 DM, but did not appear to confer risk for diabetic chronic complications. The mutation C282Y was not associated with diabetes or its chronic complications. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4254527 Mon, 25 Jan 2010 00:00:00 +0100 4254527 http://www.medworm.com/index.php?rid=4090227&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709001342%2Fabstract%3Frss%3Dyes Abstract: A substantial fraction of patients with diabetes mellitus develop end-stage renal disease. We wanted to study the influence of renal structural changes on the response to treatment of the systemic blood pressure (BP) in type 2 diabetic patients with micro- or macroalbuminuria.Methods: A 5-year observational prospective study of 40 type 2 diabetic patients. Renal biopsy was performed on the indication micro-macroalbuminuria. Twenty-four-hour ambulatory BP and urine sampling were performed yearly. The goal for treatment was a nightly systolic BP below 140 mmHg. Glomerular filtration rate was examined early with plasma clearance of iohexol.Results: The nightly systolic BP goal (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4090227 Mon, 25 Jan 2010 00:00:00 +0100 4090227 http://www.medworm.com/index.php?rid=4254523&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709001275%2Fabstract%3Frss%3Dyes Abstract: Objective: To assess the accuracy, determinants, and consequences of body weight self-perception in type 2 diabetes.Methods: We studied 1272 community-based patients and a 518-patient overweight/obese subset who returned for ≥4 annual reviews. Multiple logistic regression was used to identify baseline predictors of correct weight self-perception and to determine whether correct weight self-perception predicted future weight loss. Overweight and obesity were defined as body mass indices of 25.0–29.9 and ≥30.0 kg/m2, respectively.Results: Of the patients who were overweight (40.0%) or obese (41.8%) at baseline, 52.8% and 83.7%, respectively, correctly self-identified their weight category. Overweight/obese participants who self-identified correctly were more likely to have be... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4254523 Mon, 04 Jan 2010 00:00:00 +0100 4254523 http://www.medworm.com/index.php?rid=3637777&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709001287%2Fabstract%3Frss%3Dyes Conclusions: We conclude that the m.14709T>C mutation in the tRNAGlu gene could be a cause of mitochondrial diabetes in Tunisian affected families. In addition, the heteroplasmic loads correlated with the severity and the onset of mitochondrial diabetes in one family but not in the other, suggesting the presence of environmental factors or nuclear modifier genes. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3637777 Mon, 04 Jan 2010 00:00:00 +0100 3637777 http://www.medworm.com/index.php?rid=3058175&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709001226%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3058175 Sat, 05 Dec 2009 14:09:03 +0100 3058175 http://www.medworm.com/index.php?rid=4254526&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709001172%2Fabstract%3Frss%3Dyes Abstract: Objective: The aim of this study was to compare the bone mass in young adolescents and adult women with Type 1 diabetes mellitus (T1DM) and determine its relationship with sex steroid and sex hormone-binding globulin (SHBG) levels.Design: Cross-sectional study.Patients: We studied a group of adolescents and adult women with T1DM (n=45) and 50 healthy controls (C) matched by gynecological age and body mass index in a case-control study. Girls with menarche within the last 18–40 months (n=17 T1DM and 32 C) and adult women (age=30.4+1.4 years; n=28 T1DM and 18 C) were recruited.Measurements: Bone mass was evaluated with a GE Lunar Prodigy densitometer. Sex steroid levels were measured by radioimmunoassay.Results: Bone mass was lower in adolescents with T1DM than in control adolesc... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4254526 Thu, 03 Dec 2009 00:00:00 +0100 4254526 http://www.medworm.com/index.php?rid=4090228&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709001160%2Fabstract%3Frss%3Dyes Abstract: Objective: Obesity remains one of the most important modifiable risk factors for the prevention of Type 2 diabetes and its related comorbid conditions. The aim of this study was to examine trends in average body mass index (BMI), waist circumference, and obesity prevalence among adults with and without Type 2 diabetes.Methods: Information on BMI and waist circumference among 4162 adults with and 40,376 adults without Type 2 diabetes was obtained from the National Health and Examination Surveys completed during years 1976–2006. Mean BMI, waist circumference and prevalence of total obesity (BMI ≥30 kg/m2) and obesity stage III (BMI ≥40 kg/m2) were determined by survey periods after adjustment for the survey period weights and age standardization to the US 2000 Census. Means a... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4090228 Mon, 16 Nov 2009 00:00:00 +0100 4090228 http://www.medworm.com/index.php?rid=4254530&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270900097X%2Fabstract%3Frss%3Dyes Abstract: Neuropathy needs to be diagnosed early to prevent complications, such as neuropathic pain or the diabetic foot. It is obvious that diagnosis of neuropathy needs to be improved. New peripheral nerve function tests that appear to facilitate diagnosis are now emerging. This review outlines the new tests that have been proposed for the diagnosis of diabetic distal symmetric polyneuropathy, the commonest form of neuropathy in diabetes. New tests are classified into those mainly assessing large-fiber function (tactile circumferential discriminator, steel ball-bearing, and automated nerve conduction study) and those mainly assessing small-fiber function (NeuroQuick and Neuropad). Emerging tests are promising but must be evaluated in prospective studies. Moreover, their cost-effectivenes... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4254530 Mon, 09 Nov 2009 00:00:00 +0100 4254530 http://www.medworm.com/index.php?rid=4254525&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000956%2Fabstract%3Frss%3Dyes Conclusion: In managing diabetic patients, knowledge of hemoglobinopathies influencing HbA1c determination methods is essential because hemoglobin variants may cause mismanagement of diabetes. Unusual results should prompt further analysis for a hemoglobinopathy as the potential cause of aberrant results. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4254525 Mon, 09 Nov 2009 00:00:00 +0100 4254525 http://www.medworm.com/index.php?rid=4090233&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000968%2Fabstract%3Frss%3Dyes Abstract: Myo-inositol oxygenase (MIOX) is the first and rate-limiting enzyme in myo-inositol (MI) metabolism pathway. The increase in MIOX enzyme activity is in proportion to serum glucose concentrations and may be responsible for the MI depletion found in the diabetic complications. The aim was to investigate whether single nucleotide polymorphisms (SNPs) in the MIOX gene are associated with Type 1 diabetes mellitus (T1D) and its complications. Four hundred thirty Caucasian patients with T1D were recruited: 172 patients had diabetic nephropathy, 140 had diabetic retinopathy/neuropathy, 118 patients had diabetes for ≥20 years without microvascular complications and 224 were normal controls. Three SNPs, rs761745 (C/T), and rs2232873 (A/G) in the promoter and rs1055271 (C/G) in the 3′-u... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4090233 Mon, 09 Nov 2009 00:00:00 +0100 4090233 http://www.medworm.com/index.php?rid=2952153&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270900107X%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2952153 Sun, 01 Nov 2009 00:00:00 +0100 2952153 http://www.medworm.com/index.php?rid=4254528&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000981%2Fabstract%3Frss%3Dyes Conclusion: Induced diabetes resulted in insulin resistance, hyperlipidemia, and hypoleptinemia, while LA ameliorates these changes and improves insulin sensitivity. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4254528 Fri, 30 Oct 2009 00:00:00 +0100 4254528 http://www.medworm.com/index.php?rid=4254531&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000932%2Fabstract%3Frss%3Dyes Conclusions: Insoles appear of use for the prevention of neuropathic diabetic foot ulceration, although evidence is limited. Clinical recommendation regarding type and specification of insole is not possible at this time.There is an essential need for a large well-designed RCT comparing different types of commonly used insole for the prevention of ulceration in the diabetic neuropathic foot. Outcome measures should include patient perceptions of the effectiveness and cost-effectiveness analysis. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4254531 Mon, 26 Oct 2009 00:00:00 +0100 4254531 http://www.medworm.com/index.php?rid=3505989&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000920%2Fabstract%3Frss%3Dyes Abstract: Dipeptidyl peptidase IV (DPP4) inhibitors have recently become widely used for treating type 2 diabetes, but in meta-analyses are associated with a mildly increased risk of all-cause infections. CD26 is a cell-surface form of DPP4 which can costimulate T-cell proliferation, raising the possibility that DPP4 inhibitors might adversely affect immune function. To address this issue in an observational study, two groups of 20 subjects each were recruited from a private endocrinology practice; one group consisted of type 2 diabetes patients treated for at least 6 months with the DPP4 inhibitor, sitagliptin, whereas patients in the other group had never been treated with this agent. The groups were similar with regard to sex and racial composition, body mass index, hemoglobin A1c, and ... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3505989 Mon, 26 Oct 2009 00:00:00 +0100 3505989 http://www.medworm.com/index.php?rid=4254529&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000944%2Fabstract%3Frss%3Dyes Conclusion: Significant reductions (P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4254529 Thu, 15 Oct 2009 00:00:00 +0100 4254529 http://www.medworm.com/index.php?rid=4090231&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000725%2Fabstract%3Frss%3Dyes Conclusion: All three methods for assessment of hypoglycemia awareness are feasible in clinical practice since the degree of awareness is associated with risk of severe hypoglycemia. The trisected method (C) identifies an intermediate group with impaired awareness and with a risk of severe hypoglycemia that is significantly different from those of aware and unaware patients. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4090231 Sun, 04 Oct 2009 23:00:00 +0100 4090231 http://www.medworm.com/index.php?rid=3922398&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000919%2Fabstract%3Frss%3Dyes Abstract: Background: Simple and efficient screening methods are lacking for diabetic peripheral neuropathy (DPN), the most common and most difficult to treat of the long-term diabetic complications. Increased levels of transforming growth factor beta 1 (TGFβ1) in type 2 diabetic patients (T2DM) plays an immunomodulatory role in diabetic nephropathy and, possibly, in atherosclerotic evolution. Since preliminary interrelationships between experimental DPN and TGFβ1 have been observed, we sought to assess whether TGFβ1 could be a biomarker molecule for human DPN.Materials and Methods: Cross-sectional cohort study focused on the assessment of the interrelationships between TGFβ1 levels, cardiovascular disease (CVD), diabetic nephropathy (DNF), and neuropathy (DPN) in a group of T2DM patie... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3922398 Sun, 04 Oct 2009 23:00:00 +0100 3922398 http://www.medworm.com/index.php?rid=4254532&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000701%2Fabstract%3Frss%3Dyes Abstract: The purpose of this article is to provide reasons to start looking more critically at the existing glucose-lowering therapies in diabetes, from the point of their effect on cardiac metabolism. The presented arguments begin with the description of major differences between metabolism in myocardium and the skeletal muscle and of examples of myocardial metabolic inflexibility observed in heart failure and Type 2 diabetes. It is proposed that the metabolic inflexibility of diabetic myocardium should be taken into consideration as a factor to explain causes of unexpected cardiovascular mortality observed in the recently published outcome studies such as Action to Control Cardiovascular Risk in Diabetes (ACCORD) and Veterans Affairs Diabetes Feasibility Trial. The same reasoning was ap... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4254532 Fri, 25 Sep 2009 00:00:00 +0100 4254532 http://www.medworm.com/index.php?rid=4090232&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000737%2Fabstract%3Frss%3Dyes Conclusion: Among patients of poorly controlled diabetes and their close family members, there was a gross lack of knowledge of complications of diabetes, causes of obesity, treatment of diabetes, and use of insulin. Denial of obesity was commonly observed. Linking obesity with tubal ligation in female patients not only is appalling but may possibly be a hindrance to family planning program. Level of education had no bearing on these misconceptions. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4090232 Sun, 13 Sep 2009 23:00:00 +0100 4090232 http://www.medworm.com/index.php?rid=3922404&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000749%2Fabstract%3Frss%3Dyes Conclusions: Given the mechanism by which diabetic peripheral neuropathy can result, targeting the polyol pathway as a method of treatment appears promising, yet the efficacy of newer AR inhibitors is still to be proven. Currently, these agents are not marketed in the United States. As newer studies emerge, diabetes educators will learn more about their efficacy and safety in preventing and treating diabetic peripheral neuropathy. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3922404 Sun, 13 Sep 2009 23:00:00 +0100 3922404 http://www.medworm.com/index.php?rid=3922397&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000713%2Fabstract%3Frss%3Dyes Conclusion: The best GR obtained with combined administration of glycerol, pyruvate, and l-lactate (100 mg/kg) during long-term IIH was a consequence of the higher liver availability of these substances associated with a maintained liver ability to produce glucose from gluconeogenic substrates. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3922397 Sun, 13 Sep 2009 23:00:00 +0100 3922397 http://www.medworm.com/index.php?rid=2754176&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000841%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2754176 Mon, 31 Aug 2009 23:00:00 +0100 2754176 http://www.medworm.com/index.php?rid=4090236&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000683%2Fabstract%3Frss%3Dyes Abstract: Objective: We investigated the efficacy of epalrestat, an aldose reductase inhibitor, for diabetic peripheral neuropathy in Japanese patients with type 2 diabetes.Methods: A total of 38 type 2 diabetic patients (22 men and 16 women; mean±S.E.M. age 63.3±1.0 years; duration of diabetes 9.6±0.8 years) with diabetic neuropathy were newly administered 150 mg/day epalrestat (EP group). Motor nerve conduction velocity (MCV), sensory nerve conduction velocity (SCV), and minimum F-wave latency were evaluated before administration of epalrestat and after 1 and 2 years. Serum Nɛ-carboxymethyl lysine (CML) as a parameter of advanced glycation end products (AGEs), lipid peroxide, and soluble vascular cell adhesion molecule (sVCAM)-1 as a parameter of angiopathy were measured before admin... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4090236 Thu, 27 Aug 2009 23:00:00 +0100 4090236 http://www.medworm.com/index.php?rid=4090230&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000695%2Fabstract%3Frss%3Dyes Abstract: Objective: To measure trends in glycemic control in type 2 diabetes in the United States from 1988–1994 to 1999–2004 and to identify factors influencing glycemic control, including the presence of comorbid conditions and race/ethnicity.Methods: Participants in the National Health and Nutrition Examination Surveys (1988–1994 and 1999–2004) aged ≥30 years with diagnosed type 2 diabetes were identified. Outcome measures included glycemic control [glycosylated hemoglobin (A1C) (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4090230 Thu, 27 Aug 2009 23:00:00 +0100 4090230 http://www.medworm.com/index.php?rid=3308572&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270900066X%2Fabstract%3Frss%3Dyes Conclusions: The contractile function of rat's bladder including normal rats, diabetic rats, and diabetic rats treated with insulin is similar to the ‘Starling mechanism.’ It can be impaired by hyperglycemia, and insulin treatment is helpful to restore this function. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308572 Wed, 12 Aug 2009 00:00:00 +0100 3308572 http://www.medworm.com/index.php?rid=4090234&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000671%2Fabstract%3Frss%3Dyes Abstract: The aim of this study is to evaluate the awareness, perception, sources of information, and knowledge of diabetes mellitus and periodontal health among Jordanians, to examine the factors related to their knowledge, and organize effective education programs. A random sample of 500 diabetic patients was recruited from three hospitals and three comprehensive health centers that represent both urban and rural populations in Jordan between September 25, 2006, and February 20, 2007. Completed questionnaires with the answers were returned by 405 participants (response rate was 81%). Only 28% indicated that they followed up gum diseases with the dentist; 48% were aware that diabetic patients are more prone to gum diseases and oral health complications. About a third (38%) recognized that... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=4090234 Wed, 22 Jul 2009 23:00:00 +0100 4090234 http://www.medworm.com/index.php?rid=3922402&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270900049X%2Fabstract%3Frss%3Dyes In conclusion, our findings suggest that the dual effects of glucose on cell proliferation and development are dose dependent. Metformin not only significantly decreased intracellular ROS and apoptosis, but also had a direct osteogenic effect on osteoblasts at all glucose concentrations, which could be partially mediated via promotion of Runx2 and IGF-1 expression. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3922402 Wed, 22 Jul 2009 23:00:00 +0100 3922402 http://www.medworm.com/index.php?rid=3637774&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000348%2Fabstract%3Frss%3Dyes Abstract: Aim: To examine the diabetes self-care behaviors of Filipino-American (FA) adults with type 2 diabetes mellitus (DM).Method: The Summary of Diabetes Self Care Activities–Revised and Expanded measure was administered to 192 (74 males and 118 females) FA adult immigrants with type 2 DM.Results: Older FAs (≥65 years), females, those who were older when they immigrated, and participants diagnosed with type 2 DM longer were more likely to follow recommended medication regimens. Younger FAs ( (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3637774 Thu, 16 Jul 2009 23:00:00 +0100 3637774 http://www.medworm.com/index.php?rid=3922400&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000488%2Fabstract%3Frss%3Dyes Abstract: Objective: To evaluate the prevalence of impaired fasting glucose (IFG) and its relationship with cardiovascular risk factors in Han adolescents aged 13 to 18 years.Methods: Step 1: A cross-sectional study was conducted on 3937 Han adolescents. IFG was defined as a fasting glucose of 5.6 to 7.0 mmol/l. Measurements included anthropometric measurements, fasting plasma glucose (FPG), and serum lipids. Step 2: We identified 60 adolescents with IFG from the IFG group using a random number table, and 60 adolescents with normal fasting glucose (NFG) were matched for age and gender with the random IFG sample. Serum true insulin (TI) was further measured.Results: (1) The prevalence of IFG was 3.5% and was similar in boys and girls (3.9% vs. 3.1%, P=.177). The prevalence of IFG in adolesc... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3922400 Sun, 05 Jul 2009 23:00:00 +0100 3922400 http://www.medworm.com/index.php?rid=3922395&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000518%2Fabstract%3Frss%3Dyes Conclusions: Pio treatment in T2DM significantly reduced hepatic lipid and increased adiponectin independent of weight change, while decreasing hs-CRP with weight loss. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3922395 Sun, 05 Jul 2009 23:00:00 +0100 3922395 http://www.medworm.com/index.php?rid=3637770&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000506%2Fabstract%3Frss%3Dyes Conclusions: Glycemic regulation, dyslipidemia, and renal dysfunction were all related to mortality and IHD in a 13-year follow-up of long-term Danish type 1 diabetic patients. These results underscore the better outcome for tightly regulated type 1 diabetic patients, even in long-term survivors. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3637770 Sun, 05 Jul 2009 23:00:00 +0100 3637770 http://www.medworm.com/index.php?rid=2489362&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000056%2Fabstract%3Frss%3Dyes We have previously reported that mosapride citrate, 5-HT4 receptor agonist, improved glycemic control in Type 2 diabetes patients. Administration of mosapride citrate (15 mg/day) orally for 8 weeks decreased fasting blood glucose, HbA1c and serum insulin levels. Mosapride increased the glucose infusion rate during hyperinsulinemic–normoglycemic glucose clamp study and increased tyrosine autophosphorylation as well as the number of insulin receptors on the erythrocytes of the patients, and expression of 5-HT4 receptors was detected in muscles; therefore, we concluded that mosapride citrate improved insulin sensitivity in the muscles in Type 2 diabetic patients (). (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2489362 Thu, 25 Jun 2009 07:36:48 +0100 2489362 http://www.medworm.com/index.php?rid=2489357&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000622%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2489357 Thu, 25 Jun 2009 07:36:48 +0100 2489357 http://www.medworm.com/index.php?rid=3922401&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000464%2Fabstract%3Frss%3Dyes Abstract: The aim of this study was to investigate the modulating effect of atorvastatin on serum paraoxonase 1 enzyme (PON1) activity in type 2 diabetic Egyptian patients with or without nephropathy. The present study was carried out on the following groups: control group, which consisted of 30 healthy persons; Group I, which consisted of 20 type 2 diabetic patients without nephropathy; and Group II, which consisted of 20 type 2 diabetic patients with nephropathy. All the patients selected were under an antidiabetic regimen of insulin, and patients receiving antihypertensive agents were excluded from the follow-up study to avoid drug interaction fallacies. Twenty-two patients (15 without nephropathy and seven with nephropathy) received atorvastatin in individually adjusted oral dosage (ra... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3922401 Tue, 23 Jun 2009 23:00:00 +0100 3922401 http://www.medworm.com/index.php?rid=3922399&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000452%2Fabstract%3Frss%3Dyes Abstract: Nitric oxide (NO) unavailability plays an important role in the progression of macrovascular diseases in Type 2 diabetes (T2DM). C59038T polymorphism in GTP cyclohydrolase 1 (GCH1) gene is a functional mutation involved in NO metabolism and cardiovascular risk in a multiethnic population. To clarify the relationship between C59038T polymorphism and macrovascular disease in T2DM, an association study was performed among 611 unrelated T2DM patients. C59038T polymorphism was detected by polymerase chain reaction (PCR) restriction fragment length polymorphism. The PCR products after digestion displayed three genotypes, including CC, CT, and TT. The prevalence of cardiovascular disease, cerebrovascular disease, and peripheral vascular disease was significantly higher in T2DM patients ... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3922399 Tue, 09 Jun 2009 23:00:00 +0100 3922399 http://www.medworm.com/index.php?rid=3922396&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000476%2Fabstract%3Frss%3Dyes Conclusions: Future research would benefit from the use of community-based representative samples. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3922396 Sun, 31 May 2009 23:00:00 +0100 3922396 http://www.medworm.com/index.php?rid=3058181&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000440%2Fabstract%3Frss%3Dyes Conclusions: The QoL of Jordanian adolescents with type 1 diabetes was low. Better glycemic control may contribute to the improvement of QoL. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3058181 Mon, 25 May 2009 00:00:00 +0100 3058181 http://www.medworm.com/index.php?rid=3637769&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000336%2Fabstract%3Frss%3Dyes Abstract: Objectives: To examine the relationship between depression and glycemic control in the Strong Heart Study (SHS), a longitudinal study of cardiovascular disease in American Indians.Methods: This cross-sectional analysis focused on the relationship between depression, diabetes and glycemic control among 2832 individuals aged ≥15 years. Depression was measured by the Center for Epidemiologic Studies of Depression Scale and diabetes by American Diabetes Association criteria. An ordered logit regression model was used to assess whether diabetes was related to level of depression (none, mild, moderate, severe). Multiple logistic regression was used to explore the relationship between A1c and severe depression in participants with diabetes.Results: Rates of depression were higher in m... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3637769 Tue, 19 May 2009 23:00:00 +0100 3637769 http://www.medworm.com/index.php?rid=2371058&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001158%2Fabstract%3Frss%3Dyes Abstract: Objective: The purpose of this study was to elucidate the relationship between fasting plasma glucose (FPG), development of diabetes, and incident heart failure (HF) in a large, community sample of nondiabetic subjects.Research Design and Methods: From Kaiser Permanente Northwest medical records, we identified 10,113 subjects with an FPG level of 100–125 mg/dl in 1997 or 1998 who were free of diabetes and HF and matched them to an equal number of subjects with an FPG level of (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371058 Wed, 29 Apr 2009 01:29:00 +0100 2371058 http://www.medworm.com/index.php?rid=2371057&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001353%2Fabstract%3Frss%3Dyes Abstract: The National Institute of Diabetes and Digestive and Kidney Diseases sponsored a meeting recently to explore new ways to assess diabetic retinopathy and neuropathy, both in diabetic patients and in diabetic mice. The workshop compared current gold standards for assessment of retinopathy and neuropathy, new improvements of existing techniques, and new functional biomarkers measured with nontraditional technologies. Since the anatomical changes that comprise diabetic retinopathy and neuropathy take long to develop and have proven difficult to arrest once initiated, some talks highlighted the value of methods that are based on the pathophysiology that precedes, and might contribute to, the histopathology. In addition, a goal of the workshop was to produce a set of working criteria o... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371057 Wed, 29 Apr 2009 01:28:41 +0100 2371057 http://www.medworm.com/index.php?rid=2371056&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001092%2Fabstract%3Frss%3Dyes This study aimed to observe the effect of simvastatin on the serum monocyte chemoattractant protein-1 (MCP-1) and intracellular adhesion molecule-1 (ICAM-1) levels and to probe its protective mechanisms on macroangiopathy in diabetic rats.Methods: Twenty-four Wistar rats were randomly assigned to a normal control group (Group A, n=8), and STZ-induced diabetic group (Group B, n=8), or a simvastatin-treated diabetic group (Group C, n=8). Rats in Group C were treated with simvastatin (20 mg kg−1 day−1) 1 week after the establishment of the diabetic model. Groups A and B were treated with corresponding sodium chloride. Peripheral blood glucose was tested weekly; serum MCP-1, ICAM-1, and HbA1c levels were tested at the eighth week.Results: At the second, fourth, and eighth week, peripheral ... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371056 Wed, 29 Apr 2009 01:28:29 +0100 2371056 http://www.medworm.com/index.php?rid=2371055&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001079%2Fabstract%3Frss%3Dyes In this study, we administrated GLY to streptozotocin-induced diabetic rats and determined the effects of such treatment on activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) from brain tissue.Results and Discussion: Brain CAT and GPx activities were not significantly different in the diabetic group compared to controls (P>.05), but the SOD activity was significantly reduced in the diabetic group compared to controls (P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371055 Wed, 29 Apr 2009 01:28:13 +0100 2371055 http://www.medworm.com/index.php?rid=2371054&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000251%2Fabstract%3Frss%3Dyes Abstract: Wersternized diet, containing high fat diet intake combined with high consumption of softdrinks, is accused with the emerge of modern epidemic obesity and diabesity. Therefore, we aimed to study the effect of this diet combination on the homeostasis of glucose, lipids, and some adipohormones in rats and to simulate the metabolic perturbations induced by the unhealthy Westernized diet intake, leading to the development of type 2 diabetes. To achieve this, we divided male Wistar rats (80–120 g) into two main groups: the first was fed commercial normal fat diet and the second received an in-house-prepared high-fat diet (HFD), combined with fructose in drinking water for a period of 6 weeks, followed by a subdiabetogenic dose of streptozotocin (STZ) (35 mg/kg) to produce frank hype... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371054 Wed, 29 Apr 2009 01:27:34 +0100 2371054 http://www.medworm.com/index.php?rid=2371053&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001407%2Fabstract%3Frss%3Dyes In this study, concentration of serum ferritin, iron, transferrin saturation and hemoglobin, MCV, and MCH was significantly higher in the GDM group and TIBC was significantly lower in this group (P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371053 Wed, 29 Apr 2009 01:27:12 +0100 2371053 http://www.medworm.com/index.php?rid=2371052&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000366%2Fabstract%3Frss%3Dyes Conclusion: The incidence of DR in our study was similar to—but progression of DR was higher than—those reported in Caucasians. More frequent retinal screening should be offered to those with baseline DR, high HbA1c, or albuminuria. Good glycemic control is important in order to prevent the development and progression of DR, and can lead to regression of DR. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371052 Wed, 29 Apr 2009 01:26:53 +0100 2371052 http://www.medworm.com/index.php?rid=2371051&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270700147X%2Fabstract%3Frss%3Dyes Abstract: CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. Recent reports have shown that inflammation is one of potential pathogenic mechanisms for diabetic nephropathy. However, information on inflammation related with CXC chemokines in human Type 2 diabetic nephropathy still remains scarce. We measured urinary and serum levels of three CXC chemokines, CXCL5, CXCL8 and CXCL9, in 45 Type 2 diabetic patients (DM), 42 primary renal disease (PRD) patients and 22 healthy controls by enzyme-linked immunosorbent assay. Urinary levels of CXCL5, CXCL8 and CXCL9 in DM were significantly elevated compared to those in controls (P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371051 Wed, 29 Apr 2009 01:26:44 +0100 2371051 http://www.medworm.com/index.php?rid=2371050&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270800024X%2Fabstract%3Frss%3Dyes In conclusion, switching from long-term treatment with α-lipoic acid to central analgesic drugs such as gabapentin in painful diabetic neuropathy was associated with considerably higher rates of side effects, frequencies of outpatient visits, and daily costs of treatment. The pathogenic treatment option represents for the practicing diabetologist an effective, safe, and cost-effective treatment option for the majority of patients with diabetic polyneuropathy. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371050 Wed, 29 Apr 2009 01:26:39 +0100 2371050 http://www.medworm.com/index.php?rid=2371049&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001341%2Fabstract%3Frss%3Dyes Conclusion: This study indicates that increased levels of the proinflammatory markers and AMs occur in type 2 DM. Vitamin E administration appears beneficial in lowering proinflammatory markers and their downstream effectors that played an important role in diabetic complications following CABG. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371049 Wed, 29 Apr 2009 01:26:20 +0100 2371049 http://www.medworm.com/index.php?rid=2371048&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000044%2Fabstract%3Frss%3Dyes Abstract: Objective: The aim of this study was to examine the interaction between cardiorespiratory capacity and cardiovascular risk factors in patients with Type 2 diabetes mellitus (T2DM).Research Design/Methods: A total of 92 patients with T2DM (40 men, 52 women) performed a symptom-limited exercise test on ergocycle, with continuous gas exchange measurement. All patients were overweight or obese (body mass index >25 kg/m2), with poor glycemic control (hemoglobin A1c >7%), but free from overt diabetic vascular complications. Anthropometric parameters, blood pressure (BP), cardiorespiratory fitness, glycemic and lipid profile, fibrinogen, plasminogen activator inhibitor-1, high-sensitivity C-reactive protein (hsCRP), insulin resistance, and 24-h urinary albumin excretion (UAE) were measu... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371048 Wed, 29 Apr 2009 01:25:46 +0100 2371048 http://www.medworm.com/index.php?rid=2371047&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001493%2Fabstract%3Frss%3Dyes Conclusion: The ED prevalence rate assessed by a single question was comparable to that assessed by questionnaires. ED neither did independently relate to patients' cardiovascular history nor to cardiovascular risk. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371047 Wed, 29 Apr 2009 01:24:50 +0100 2371047 http://www.medworm.com/index.php?rid=2371046&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000397%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371046 Wed, 29 Apr 2009 01:24:42 +0100 2371046 http://www.medworm.com/index.php?rid=3308564&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000300%2Fabstract%3Frss%3Dyes Abstract: Objective: To systematically investigate the effect of lack of adherence to the recommended change in insulin pump infusion line use beyond 48 h and determine whether the type of insulin made a difference.Research design and methods: This was a double-blind, randomized, crossover trial with 20 patients with diabetes mellitus I using insulins aspart and lispro without a line change for up to 100 h. Using retrospective continuous glucose monitoring, we analyzed the average glucose over the day. Changes in serum 1,5-anhydroglucitol, carboxymethyllysine, and free 15-F2t isoprostane were also studied.Results: From Day 2 to Day 5 of the pump line use, the daily average glucose level increased from 122.7 to 163.9 mg/dl (P 180 mg/dl increased from 14.5% to 38.3% (P (Source: Journal of Di... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308564 Fri, 24 Apr 2009 00:00:00 +0100 3308564 http://www.medworm.com/index.php?rid=3637778&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000294%2Fabstract%3Frss%3Dyes Conclusions: Heavy long-term exercise alters the dynamics but not the amplitude of unloaded myocyte contraction in the STZ-induced diabetic rat. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3637778 Thu, 23 Apr 2009 23:00:00 +0100 3637778 http://www.medworm.com/index.php?rid=3637773&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000324%2Fabstract%3Frss%3Dyes Abstract: Endoglin is an accessory receptor molecule that, in association with transforming growth factor β (TGF-β) family receptors Types I and II, binds TGF-β1, TGF-β3, activin A, bone morphogenetic protein (BMP)-2 and BMP-7, regulating TGF-β dependent cellular responses. Relevant to diabetic nephropathy, endoglin, expressed in vascular endothelial and smooth muscle cells, fibroblasts, and mesangial cells, negatively regulates extracellular matrix (ECM). The aim of this study was to evaluate endoglin expression in cultured skin fibroblasts from patients with Type 1 diabetes with and without diabetic nephropathy. Kidney and skin biopsies were performed in 125 Type 1 diabetic patients. The 20 with the fastest rate of mesangial expansion (estimated by electron microscopy) and proteinur... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3637773 Thu, 23 Apr 2009 23:00:00 +0100 3637773 http://www.medworm.com/index.php?rid=3505987&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000312%2Fabstract%3Frss%3Dyes Conclusions: Genetic variations in the NOS2 gene promoter and TLR4 coding sequence may lead to deleterious and protective effects, respectively, arising from altered function of the innate immune system in patients with T2DM. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3505987 Thu, 23 Apr 2009 23:00:00 +0100 3505987 http://www.medworm.com/index.php?rid=3637779&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000282%2Fabstract%3Frss%3Dyes Abstract: Although animal studies suggested that there may be a role for antioxidants (especially alpha-tocopherol) as therapy for heart failure (HF), the results obtained from human trials are disappointing. The variability in the response to antioxidant therapy may be due to genetic polymorphisms in enzymes involved in oxidative stress. We strongly believe that we do not have enough data supporting the use of antioxidant treatment in the management of HF patients, including a diabetic subset. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3637779 Mon, 30 Mar 2009 23:00:00 +0100 3637779 http://www.medworm.com/index.php?rid=3637776&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000270%2Fabstract%3Frss%3Dyes Abstract: Background: To evaluate the survival after major lower limb amputation, at a level either below (BKA) or above (AKA) the knee, in diabetic patients admitted to hospital because of critical limb ischemia (CLI).Methods: From January 1999 to December 2003, 564 diabetic patients were consecutively admitted to our Foot Center because of CLI and followed up until December 2005. A revascularization procedure was performed in 537 patients (95.2%): in 420 with peripheral angioplasty, in 117 with peripheral bypass graft. Neither endoluminal nor surgical revascularization was practicable in 27 (4.8%) patients.Results: Major amputation was performed in a total of 55 (9.8%) patients. Among the clinical and demographic variables evaluated, age was significantly lower (67.3±10.1 vs. 76.7±10.4... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3637776 Mon, 30 Mar 2009 23:00:00 +0100 3637776 http://www.medworm.com/index.php?rid=3505984&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000087%2Fabstract%3Frss%3Dyes Abstract: Both insulin resistance and decreased insulin secretion are major features of the pathophysiology of type 2 diabetes. Inflammatory pathways are found to be critical in mechanisms underlying insulin resistance, which is a major determinant of increased risk of cardiovascular complications in type 2 diabetes, and so, it is a potential therapeutic target. Thiazolidinediones (e.g., rosiglitazone) act primarily as insulin sensitizers and were discovered to have anti-inflammatory effects leading to reevaluation of their potential use in treatment of diabetes. Acetyl salicylic acid (aspirin), which is currently recommended for cardiovascular disease (CVD) or even CVD risk factors, is shown to ameliorate diabetic process. This work aimed to study correlation between homeostasis model ass... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3505984 Mon, 30 Mar 2009 23:00:00 +0100 3505984 http://www.medworm.com/index.php?rid=3505981&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000026%2Fabstract%3Frss%3Dyes Conclusion: The prevalence rates of diabetes and MetS among US Asian Indians are higher than reported in earlier, nonrandomized, smaller surveys. These data provide a firm basis for future mechanistic and interventional studies. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3505981 Mon, 23 Mar 2009 00:00:00 +0100 3505981 http://www.medworm.com/index.php?rid=3308569&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000245%2Fabstract%3Frss%3Dyes Conclusion: The A118G polymorphism of mu-opioid receptor may be closely associated with DFU pain in 34 out of 50 patients in the painless group and in 5 out of 15 patients in the painful group. This indicates that the nucleotide 118 variant patients may suffer less DFU pain. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308569 Mon, 23 Mar 2009 00:00:00 +0100 3308569 http://www.medworm.com/index.php?rid=3308567&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000269%2Fabstract%3Frss%3Dyes Abstract: Aim: We aim to investigate erythropoietin (EPO) response to anemia and its association with autonomic neuropathy in type 2 diabetic patients without advanced renal failure.Methods: A cross-sectional study was conducted on 211 type 2 diabetes mellitus patients without advanced renal failure [estimated glomerular filtration rate (eGFR) >40 ml/min/1.73 m2]. The response of EPO to anemia of type 2 diabetic patients without advanced renal failure was compared with those of nondiabetic control subjects. Autonomic nerve function was assessed using three cardiovascular tests (deep breathing, the Valsalva maneuver, and lying-to-standing). The results of each test were scored as 0 if normal, 1 if borderline, and 2 if abnormal. Autonomic neuropathy was diagnosed when a total score of the te... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308567 Mon, 23 Mar 2009 00:00:00 +0100 3308567 http://www.medworm.com/index.php?rid=3308574&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000257%2Fabstract%3Frss%3Dyes In this report, we describe a unique case of sepsis and a gas-forming splenic abscess caused by Clostridium septicum in a type 2 diabetes patient which was treatable solely with antibiotics. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308574 Mon, 16 Mar 2009 00:00:00 +0100 3308574 http://www.medworm.com/index.php?rid=3637772&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708001256%2Fabstract%3Frss%3Dyes Conclusions: Our results suggest that pregnancy modulates cardiovascular autonomic regulation and hemodynamics equally in subjects with GDM and without GDM, suggesting that metabolic disorder during pregnancy does not result in cardiovascular dysfunction when GDM is in good balance. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3637772 Fri, 13 Mar 2009 00:00:00 +0100 3637772 http://www.medworm.com/index.php?rid=3308566&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708001293%2Fabstract%3Frss%3Dyes Conclusion: The proportion of patients with poor glycemic control was high, which was nearly comparable to that reported from many countries. Longer duration of diabetes and not adherent to diabetes self-care management behaviors were associated with poor glycemic control. An educational program that emphasizes lifestyle modification with importance of adherence to treatment regimen would be of great benefit in glycemic control. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308566 Thu, 12 Mar 2009 00:00:00 +0100 3308566 http://www.medworm.com/index.php?rid=3308571&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000051%2Fabstract%3Frss%3Dyes Conclusions: We identified in the ADIPOQ gene a risk haplotype for type 2 diabetes in the Japanese Brazilian population. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308571 Mon, 09 Mar 2009 00:00:00 +0100 3308571 http://www.medworm.com/index.php?rid=3308570&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000063%2Fabstract%3Frss%3Dyes Abstract: Fifty-six pregnant women with gestational diabetes mellitus (GDM) and 42 normal glucose tolerant (NGT) pregnant women between 26 and 36 gestational weeks were included in the study prospectively. The body fat percentage (BFP) was calculated using the Siri formula from skinfold thickness (SFT) measurements.Both groups were comparable for gestational age, height, weight, and body mass index (P>.05). Insulin resistance assessed by homeostasis model assessment for insulin resistance (HOMA-IR) method was significantly higher in GDM patients compared to their NGT weight-matched control group. In contrast, the insulin sensitivity calculated from quantitative insulin sensitivity check index (QUICKI-IS) equation was significantly lower in GDM group. Calculated lean body mass was found to ... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308570 Mon, 09 Mar 2009 00:00:00 +0100 3308570 http://www.medworm.com/index.php?rid=3308565&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000075%2Fabstract%3Frss%3Dyes Abstract: There is increasing evidence that glycemic disorders such as rapid glucose fluctuations over a daily period might play an important role on diabetic complications. We evaluated the efficacy of sitagliptin 100 mg once daily vs. vildagliptin 50 mg twice daily on daily blood glucose fluctuations in patients with type 2 diabetes that was inadequately controlled by metformin.Forty-eight-hour continuous subcutaneous glucose monitoring (CSGM) was performed in patients treated with metformin plus vildagliptin (n=18) or sitagliptin (n=20) over a period of 3 months. The mean amplitude of glycemic excursions (MAGE) was used for assessing glucose fluctuations during the day. During a standardized meal, glucagon-like peptide-1 (GLP-1), glucagon, and insulin were measured.CSGM shows large MAGE... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308565 Thu, 05 Mar 2009 00:00:00 +0100 3308565 http://www.medworm.com/index.php?rid=2360288&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707000670%2Fabstract%3Frss%3Dyes Conclusion: Newer insulin formulations can effectively improve glycemic control without significant effects on patient weight and, therefore, may be particularly useful in patients who are overweight or obese. Implementation of comprehensive treatment regimens that emphasize dietary modification, physical activity, and exercise, and aggressive use of pharmacological agents to achieve tight glycemic control through physiological regimens offer the most promise for reducing long-term complications in obese patients with type 2 diabetes. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360288 Sun, 01 Mar 2009 05:00:00 +0100 2360288 http://www.medworm.com/index.php?rid=2360287&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000305%2Fabstract%3Frss%3Dyes We describe a 38-year-old female Type 1 diabetic patient who developed acute neck pain 3 weeks following islet transplantation. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360287 Sun, 01 Mar 2009 05:00:00 +0100 2360287 http://www.medworm.com/index.php?rid=2360286&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000743%2Fabstract%3Frss%3Dyes I read with interest the article by . They estimated the prevalence and incidence of diabetic retinopathy (DR) in a 4-year follow-up study of a Chinese population with type 2 diabetes mellitus attending a district hospital in Hong Kong (N=413). They reported the use of one pair of 45° stereo fundus photographs centered on the macula as their protocol for screening DR. This strategy seems to be appropriate for a country like China, where the ophthalmologist-to-population ratio might be low. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360286 Sun, 01 Mar 2009 05:00:00 +0100 2360286 http://www.medworm.com/index.php?rid=2360285&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270700133X%2Fabstract%3Frss%3Dyes Osteomyelitis complicates 50–60% of serious and 10–20% of less severe foot infections in diabetic patients. Cases may be mono- or polymicrobial and Staphylococcus aureus is the most commonly isolated agent (50%), while Staphylococcus epidermidis, streptococci, and Enterobacteriacea are also frequent isolates (). Fungal osteomyelitis is an uncommon disease and arises as a result of hematogenous dissemination, direct inoculation from an exogenous source, or direct extension from an adjacent focus that can be seen in diabetic foot lesions (). Candida osteomyelitis during the course of diabetic foot infections is a rare entity and was previously described in one report by . Here, we report a type 2 diabetic patient presenting with foot ulcer and metatarsal Candida albicans osteomyelitis, a... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360285 Sun, 01 Mar 2009 05:00:00 +0100 2360285 http://www.medworm.com/index.php?rid=2360284&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000342%2Fabstract%3Frss%3Dyes Conclusions: We conclude that ROS may play an important role in diabetes-induced nephropathy in this rat model. Vitamin E supplementation in addition to insulin can have additive protective effects against deterioration of renal function in this model. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360284 Sun, 01 Mar 2009 05:00:00 +0100 2360284 http://www.medworm.com/index.php?rid=2360283&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001468%2Fabstract%3Frss%3Dyes In conclusion, rosiglitazone may have a potential therapeutic target in DN, which may be partly attributed to lowering of the expression of MCP-1 in the local kidney and the urinary excretion of MCP-1. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360283 Sun, 01 Mar 2009 05:00:00 +0100 2360283 http://www.medworm.com/index.php?rid=2360282&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001432%2Fabstract%3Frss%3Dyes Abstract: The aim of the present preliminary study was to describe a simple protocol for the analysis of the heart rate variability (HRV) that can reveal the different autonomic control between noncomplicated diabetic patients and normal subjects within 15 min. The power spectrum of the HRV was evaluated on 5-min-long electrocardiographic recordings in both the supine and the seated positions in 30 noncomplicated non-insulin-dependent diabetic (NIDDM) patients and in 30 healthy volunteers. In healthy subjects the low-frequency (LF) value was higher in seated position than in supine position, while in diabetic patients the LF value in seated position did not differ from that in supine position and did not differ from that in healthy subjects in supine position. The present work demonstrates... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360282 Sun, 01 Mar 2009 05:00:00 +0100 2360282 http://www.medworm.com/index.php?rid=2360281&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001390%2Fabstract%3Frss%3Dyes Conclusions: Hispanics have poorer access to care and poorer health status compared to Whites or Blacks. Controlling for socioeconomic and access to care variables eliminated disparities in self-management but did not eliminate disparities in quality of diabetes care. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360281 Sun, 01 Mar 2009 05:00:00 +0100 2360281 http://www.medworm.com/index.php?rid=2360280&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001316%2Fabstract%3Frss%3Dyes Conclusion: The nonreplication of association suggests differential genetic susceptibility of the two populations to diabetic chronic renal insufficiency. In the SI diabetic subjects, oxidative stress pathway genes might be an important predictor for the development of diabetic complications. Further, the association of wild-type alleles may suggest that they confer greater survival ability to comorbid complications and may be nephroprotective. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360280 Sun, 01 Mar 2009 05:00:00 +0100 2360280 http://www.medworm.com/index.php?rid=2360279&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001328%2Fabstract%3Frss%3Dyes Abstract: Aims: Insofar as hypertension is a risk factor for cardiovascular morbidity and mortality in Type 2 diabetes mellitus (T2DM), this study investigated the incidence of hypertension and associated risk factors in Saudi T2DM patients.Methods: A hospital-based, 11-year (1993–2004) prospective study of 916 adult originally normotensive T2DM Saudi patients (488 male and 428 female). T2DM was diagnosed as per World Health Organization (WHO) criteria, while hypertension was assessed according to the Seventh Joint National Criteria for Hypertension Classification (JNVII). Risk factors were analyzed on those who developed hypertension.Results: The hypertension incidence was 17.2/100 person-years, based on 2833.63 person-years of cohort group follow-up. Age-adjusted Cox regression coeffic... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360279 Sun, 01 Mar 2009 05:00:00 +0100 2360279 http://www.medworm.com/index.php?rid=2360278&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270800010X%2Fabstract%3Frss%3Dyes Conclusions: Our results suggested a close relationship between poor glycemic control and increased platelet activity in patients with type 2 DM. Furthermore, platelet activity recovered through improved glycemic control, which may prevent the possible role of platelets in cardiovascular events in these patients. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360278 Sun, 01 Mar 2009 05:00:00 +0100 2360278 http://www.medworm.com/index.php?rid=2360277&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000068%2Fabstract%3Frss%3Dyes Abstract: Purpose: To describe the frequency of orthostatic hypotension and hypertension and associations with risk factors in a cohort of persons with long-term Type 1 diabetes (n=440) participating in the Wisconsin Epidemiologic Study of Diabetic Retinopathy.Methods: Evaluations included detailed medical history, electrocardiography (ECG), and laboratory tests. Blood pressure (BP) was measured in supine and standing positions. Standing decrease in systolic (SBP) or diastolic (DBP) BP of at least 20 or 10 mmHg, respectively, was defined as orthostatic hypotension; increase of SBP from (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360277 Sun, 01 Mar 2009 05:00:00 +0100 2360277