MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Diabetes and Its Complications' source. Wed, 17 Mar 2010 14:21:43 +0100 http://www.medworm.com/index.php?rid=3308563&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872710000127%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308563 Fri, 26 Feb 2010 14:12:56 +0100 3308563 http://www.medworm.com/index.php?rid=3058175&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709001226%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3058175 Sat, 05 Dec 2009 14:09:03 +0100 3058175 http://www.medworm.com/index.php?rid=2952153&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270900107X%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2952153 Sun, 01 Nov 2009 00:00:00 +0100 2952153 http://www.medworm.com/index.php?rid=2754176&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000841%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2754176 Mon, 31 Aug 2009 23:00:00 +0100 2754176 http://www.medworm.com/index.php?rid=3308572&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270900066X%2Fabstract%3Frss%3Dyes Conclusions: The contractile function of rat's bladder including normal rats, diabetic rats, and diabetic rats treated with insulin is similar to the ‘Starling mechanism.’ It can be impaired by hyperglycemia, and insulin treatment is helpful to restore this function. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308572 Wed, 12 Aug 2009 00:00:00 +0100 3308572 http://www.medworm.com/index.php?rid=2489362&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000056%2Fabstract%3Frss%3Dyes We have previously reported that mosapride citrate, 5-HT4 receptor agonist, improved glycemic control in Type 2 diabetes patients. Administration of mosapride citrate (15 mg/day) orally for 8 weeks decreased fasting blood glucose, HbA1c and serum insulin levels. Mosapride increased the glucose infusion rate during hyperinsulinemic–normoglycemic glucose clamp study and increased tyrosine autophosphorylation as well as the number of insulin receptors on the erythrocytes of the patients, and expression of 5-HT4 receptors was detected in muscles; therefore, we concluded that mosapride citrate improved insulin sensitivity in the muscles in Type 2 diabetic patients (). (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2489362 Thu, 25 Jun 2009 07:36:48 +0100 2489362 http://www.medworm.com/index.php?rid=2489357&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000622%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2489357 Thu, 25 Jun 2009 07:36:48 +0100 2489357 http://www.medworm.com/index.php?rid=3058181&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000440%2Fabstract%3Frss%3Dyes Conclusions: The QoL of Jordanian adolescents with type 1 diabetes was low. Better glycemic control may contribute to the improvement of QoL. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3058181 Mon, 25 May 2009 00:00:00 +0100 3058181 http://www.medworm.com/index.php?rid=2371058&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001158%2Fabstract%3Frss%3Dyes Abstract: Objective: The purpose of this study was to elucidate the relationship between fasting plasma glucose (FPG), development of diabetes, and incident heart failure (HF) in a large, community sample of nondiabetic subjects.Research Design and Methods: From Kaiser Permanente Northwest medical records, we identified 10,113 subjects with an FPG level of 100–125 mg/dl in 1997 or 1998 who were free of diabetes and HF and matched them to an equal number of subjects with an FPG level of (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371058 Wed, 29 Apr 2009 01:29:00 +0100 2371058 http://www.medworm.com/index.php?rid=2371057&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001353%2Fabstract%3Frss%3Dyes Abstract: The National Institute of Diabetes and Digestive and Kidney Diseases sponsored a meeting recently to explore new ways to assess diabetic retinopathy and neuropathy, both in diabetic patients and in diabetic mice. The workshop compared current gold standards for assessment of retinopathy and neuropathy, new improvements of existing techniques, and new functional biomarkers measured with nontraditional technologies. Since the anatomical changes that comprise diabetic retinopathy and neuropathy take long to develop and have proven difficult to arrest once initiated, some talks highlighted the value of methods that are based on the pathophysiology that precedes, and might contribute to, the histopathology. In addition, a goal of the workshop was to produce a set of working criteria o... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371057 Wed, 29 Apr 2009 01:28:41 +0100 2371057 http://www.medworm.com/index.php?rid=2371056&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001092%2Fabstract%3Frss%3Dyes This study aimed to observe the effect of simvastatin on the serum monocyte chemoattractant protein-1 (MCP-1) and intracellular adhesion molecule-1 (ICAM-1) levels and to probe its protective mechanisms on macroangiopathy in diabetic rats.Methods: Twenty-four Wistar rats were randomly assigned to a normal control group (Group A, n=8), and STZ-induced diabetic group (Group B, n=8), or a simvastatin-treated diabetic group (Group C, n=8). Rats in Group C were treated with simvastatin (20 mg kg−1 day−1) 1 week after the establishment of the diabetic model. Groups A and B were treated with corresponding sodium chloride. Peripheral blood glucose was tested weekly; serum MCP-1, ICAM-1, and HbA1c levels were tested at the eighth week.Results: At the second, fourth, and eighth week, peripheral ... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371056 Wed, 29 Apr 2009 01:28:29 +0100 2371056 http://www.medworm.com/index.php?rid=2371055&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001079%2Fabstract%3Frss%3Dyes In this study, we administrated GLY to streptozotocin-induced diabetic rats and determined the effects of such treatment on activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) from brain tissue.Results and Discussion: Brain CAT and GPx activities were not significantly different in the diabetic group compared to controls (P>.05), but the SOD activity was significantly reduced in the diabetic group compared to controls (P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371055 Wed, 29 Apr 2009 01:28:13 +0100 2371055 http://www.medworm.com/index.php?rid=2371054&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000251%2Fabstract%3Frss%3Dyes Abstract: Wersternized diet, containing high fat diet intake combined with high consumption of softdrinks, is accused with the emerge of modern epidemic obesity and diabesity. Therefore, we aimed to study the effect of this diet combination on the homeostasis of glucose, lipids, and some adipohormones in rats and to simulate the metabolic perturbations induced by the unhealthy Westernized diet intake, leading to the development of type 2 diabetes. To achieve this, we divided male Wistar rats (80–120 g) into two main groups: the first was fed commercial normal fat diet and the second received an in-house-prepared high-fat diet (HFD), combined with fructose in drinking water for a period of 6 weeks, followed by a subdiabetogenic dose of streptozotocin (STZ) (35 mg/kg) to produce frank hype... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371054 Wed, 29 Apr 2009 01:27:34 +0100 2371054 http://www.medworm.com/index.php?rid=2371053&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001407%2Fabstract%3Frss%3Dyes In this study, concentration of serum ferritin, iron, transferrin saturation and hemoglobin, MCV, and MCH was significantly higher in the GDM group and TIBC was significantly lower in this group (P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371053 Wed, 29 Apr 2009 01:27:12 +0100 2371053 http://www.medworm.com/index.php?rid=2371052&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000366%2Fabstract%3Frss%3Dyes Conclusion: The incidence of DR in our study was similar to—but progression of DR was higher than—those reported in Caucasians. More frequent retinal screening should be offered to those with baseline DR, high HbA1c, or albuminuria. Good glycemic control is important in order to prevent the development and progression of DR, and can lead to regression of DR. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371052 Wed, 29 Apr 2009 01:26:53 +0100 2371052 http://www.medworm.com/index.php?rid=2371051&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270700147X%2Fabstract%3Frss%3Dyes Abstract: CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. Recent reports have shown that inflammation is one of potential pathogenic mechanisms for diabetic nephropathy. However, information on inflammation related with CXC chemokines in human Type 2 diabetic nephropathy still remains scarce. We measured urinary and serum levels of three CXC chemokines, CXCL5, CXCL8 and CXCL9, in 45 Type 2 diabetic patients (DM), 42 primary renal disease (PRD) patients and 22 healthy controls by enzyme-linked immunosorbent assay. Urinary levels of CXCL5, CXCL8 and CXCL9 in DM were significantly elevated compared to those in controls (P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371051 Wed, 29 Apr 2009 01:26:44 +0100 2371051 http://www.medworm.com/index.php?rid=2371050&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270800024X%2Fabstract%3Frss%3Dyes In conclusion, switching from long-term treatment with α-lipoic acid to central analgesic drugs such as gabapentin in painful diabetic neuropathy was associated with considerably higher rates of side effects, frequencies of outpatient visits, and daily costs of treatment. The pathogenic treatment option represents for the practicing diabetologist an effective, safe, and cost-effective treatment option for the majority of patients with diabetic polyneuropathy. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371050 Wed, 29 Apr 2009 01:26:39 +0100 2371050 http://www.medworm.com/index.php?rid=2371049&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001341%2Fabstract%3Frss%3Dyes Conclusion: This study indicates that increased levels of the proinflammatory markers and AMs occur in type 2 DM. Vitamin E administration appears beneficial in lowering proinflammatory markers and their downstream effectors that played an important role in diabetic complications following CABG. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371049 Wed, 29 Apr 2009 01:26:20 +0100 2371049 http://www.medworm.com/index.php?rid=2371048&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000044%2Fabstract%3Frss%3Dyes Abstract: Objective: The aim of this study was to examine the interaction between cardiorespiratory capacity and cardiovascular risk factors in patients with Type 2 diabetes mellitus (T2DM).Research Design/Methods: A total of 92 patients with T2DM (40 men, 52 women) performed a symptom-limited exercise test on ergocycle, with continuous gas exchange measurement. All patients were overweight or obese (body mass index >25 kg/m2), with poor glycemic control (hemoglobin A1c >7%), but free from overt diabetic vascular complications. Anthropometric parameters, blood pressure (BP), cardiorespiratory fitness, glycemic and lipid profile, fibrinogen, plasminogen activator inhibitor-1, high-sensitivity C-reactive protein (hsCRP), insulin resistance, and 24-h urinary albumin excretion (UAE) were measu... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371048 Wed, 29 Apr 2009 01:25:46 +0100 2371048 http://www.medworm.com/index.php?rid=2371047&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001493%2Fabstract%3Frss%3Dyes Conclusion: The ED prevalence rate assessed by a single question was comparable to that assessed by questionnaires. ED neither did independently relate to patients' cardiovascular history nor to cardiovascular risk. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371047 Wed, 29 Apr 2009 01:24:50 +0100 2371047 http://www.medworm.com/index.php?rid=2371046&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000397%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2371046 Wed, 29 Apr 2009 01:24:42 +0100 2371046 http://www.medworm.com/index.php?rid=3308564&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000300%2Fabstract%3Frss%3Dyes Abstract: Objective: To systematically investigate the effect of lack of adherence to the recommended change in insulin pump infusion line use beyond 48 h and determine whether the type of insulin made a difference.Research design and methods: This was a double-blind, randomized, crossover trial with 20 patients with diabetes mellitus I using insulins aspart and lispro without a line change for up to 100 h. Using retrospective continuous glucose monitoring, we analyzed the average glucose over the day. Changes in serum 1,5-anhydroglucitol, carboxymethyllysine, and free 15-F2t isoprostane were also studied.Results: From Day 2 to Day 5 of the pump line use, the daily average glucose level increased from 122.7 to 163.9 mg/dl (P 180 mg/dl increased from 14.5% to 38.3% (P (Source: Journal of Di... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308564 Fri, 24 Apr 2009 00:00:00 +0100 3308564 http://www.medworm.com/index.php?rid=3308569&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000245%2Fabstract%3Frss%3Dyes Conclusion: The A118G polymorphism of mu-opioid receptor may be closely associated with DFU pain in 34 out of 50 patients in the painless group and in 5 out of 15 patients in the painful group. This indicates that the nucleotide 118 variant patients may suffer less DFU pain. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308569 Mon, 23 Mar 2009 00:00:00 +0100 3308569 http://www.medworm.com/index.php?rid=3308567&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000269%2Fabstract%3Frss%3Dyes Abstract: Aim: We aim to investigate erythropoietin (EPO) response to anemia and its association with autonomic neuropathy in type 2 diabetic patients without advanced renal failure.Methods: A cross-sectional study was conducted on 211 type 2 diabetes mellitus patients without advanced renal failure [estimated glomerular filtration rate (eGFR) >40 ml/min/1.73 m2]. The response of EPO to anemia of type 2 diabetic patients without advanced renal failure was compared with those of nondiabetic control subjects. Autonomic nerve function was assessed using three cardiovascular tests (deep breathing, the Valsalva maneuver, and lying-to-standing). The results of each test were scored as 0 if normal, 1 if borderline, and 2 if abnormal. Autonomic neuropathy was diagnosed when a total score of the te... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308567 Mon, 23 Mar 2009 00:00:00 +0100 3308567 http://www.medworm.com/index.php?rid=3308574&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000257%2Fabstract%3Frss%3Dyes In this report, we describe a unique case of sepsis and a gas-forming splenic abscess caused by Clostridium septicum in a type 2 diabetes patient which was treatable solely with antibiotics. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308574 Mon, 16 Mar 2009 00:00:00 +0100 3308574 http://www.medworm.com/index.php?rid=3308566&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708001293%2Fabstract%3Frss%3Dyes Conclusion: The proportion of patients with poor glycemic control was high, which was nearly comparable to that reported from many countries. Longer duration of diabetes and not adherent to diabetes self-care management behaviors were associated with poor glycemic control. An educational program that emphasizes lifestyle modification with importance of adherence to treatment regimen would be of great benefit in glycemic control. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308566 Thu, 12 Mar 2009 00:00:00 +0100 3308566 http://www.medworm.com/index.php?rid=3308571&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000051%2Fabstract%3Frss%3Dyes Conclusions: We identified in the ADIPOQ gene a risk haplotype for type 2 diabetes in the Japanese Brazilian population. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308571 Mon, 09 Mar 2009 00:00:00 +0100 3308571 http://www.medworm.com/index.php?rid=3308570&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000063%2Fabstract%3Frss%3Dyes Abstract: Fifty-six pregnant women with gestational diabetes mellitus (GDM) and 42 normal glucose tolerant (NGT) pregnant women between 26 and 36 gestational weeks were included in the study prospectively. The body fat percentage (BFP) was calculated using the Siri formula from skinfold thickness (SFT) measurements.Both groups were comparable for gestational age, height, weight, and body mass index (P>.05). Insulin resistance assessed by homeostasis model assessment for insulin resistance (HOMA-IR) method was significantly higher in GDM patients compared to their NGT weight-matched control group. In contrast, the insulin sensitivity calculated from quantitative insulin sensitivity check index (QUICKI-IS) equation was significantly lower in GDM group. Calculated lean body mass was found to ... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308570 Mon, 09 Mar 2009 00:00:00 +0100 3308570 http://www.medworm.com/index.php?rid=3308565&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000075%2Fabstract%3Frss%3Dyes Abstract: There is increasing evidence that glycemic disorders such as rapid glucose fluctuations over a daily period might play an important role on diabetic complications. We evaluated the efficacy of sitagliptin 100 mg once daily vs. vildagliptin 50 mg twice daily on daily blood glucose fluctuations in patients with type 2 diabetes that was inadequately controlled by metformin.Forty-eight-hour continuous subcutaneous glucose monitoring (CSGM) was performed in patients treated with metformin plus vildagliptin (n=18) or sitagliptin (n=20) over a period of 3 months. The mean amplitude of glycemic excursions (MAGE) was used for assessing glucose fluctuations during the day. During a standardized meal, glucagon-like peptide-1 (GLP-1), glucagon, and insulin were measured.CSGM shows large MAGE... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308565 Thu, 05 Mar 2009 00:00:00 +0100 3308565 http://www.medworm.com/index.php?rid=2360288&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707000670%2Fabstract%3Frss%3Dyes Conclusion: Newer insulin formulations can effectively improve glycemic control without significant effects on patient weight and, therefore, may be particularly useful in patients who are overweight or obese. Implementation of comprehensive treatment regimens that emphasize dietary modification, physical activity, and exercise, and aggressive use of pharmacological agents to achieve tight glycemic control through physiological regimens offer the most promise for reducing long-term complications in obese patients with type 2 diabetes. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360288 Sun, 01 Mar 2009 05:00:00 +0100 2360288 http://www.medworm.com/index.php?rid=2360287&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000305%2Fabstract%3Frss%3Dyes We describe a 38-year-old female Type 1 diabetic patient who developed acute neck pain 3 weeks following islet transplantation. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360287 Sun, 01 Mar 2009 05:00:00 +0100 2360287 http://www.medworm.com/index.php?rid=2360286&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000743%2Fabstract%3Frss%3Dyes I read with interest the article by . They estimated the prevalence and incidence of diabetic retinopathy (DR) in a 4-year follow-up study of a Chinese population with type 2 diabetes mellitus attending a district hospital in Hong Kong (N=413). They reported the use of one pair of 45° stereo fundus photographs centered on the macula as their protocol for screening DR. This strategy seems to be appropriate for a country like China, where the ophthalmologist-to-population ratio might be low. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360286 Sun, 01 Mar 2009 05:00:00 +0100 2360286 http://www.medworm.com/index.php?rid=2360285&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270700133X%2Fabstract%3Frss%3Dyes Osteomyelitis complicates 50–60% of serious and 10–20% of less severe foot infections in diabetic patients. Cases may be mono- or polymicrobial and Staphylococcus aureus is the most commonly isolated agent (50%), while Staphylococcus epidermidis, streptococci, and Enterobacteriacea are also frequent isolates (). Fungal osteomyelitis is an uncommon disease and arises as a result of hematogenous dissemination, direct inoculation from an exogenous source, or direct extension from an adjacent focus that can be seen in diabetic foot lesions (). Candida osteomyelitis during the course of diabetic foot infections is a rare entity and was previously described in one report by . Here, we report a type 2 diabetic patient presenting with foot ulcer and metatarsal Candida albicans osteomyelitis, a... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360285 Sun, 01 Mar 2009 05:00:00 +0100 2360285 http://www.medworm.com/index.php?rid=2360284&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000342%2Fabstract%3Frss%3Dyes Conclusions: We conclude that ROS may play an important role in diabetes-induced nephropathy in this rat model. Vitamin E supplementation in addition to insulin can have additive protective effects against deterioration of renal function in this model. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360284 Sun, 01 Mar 2009 05:00:00 +0100 2360284 http://www.medworm.com/index.php?rid=2360283&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001468%2Fabstract%3Frss%3Dyes In conclusion, rosiglitazone may have a potential therapeutic target in DN, which may be partly attributed to lowering of the expression of MCP-1 in the local kidney and the urinary excretion of MCP-1. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360283 Sun, 01 Mar 2009 05:00:00 +0100 2360283 http://www.medworm.com/index.php?rid=2360282&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001432%2Fabstract%3Frss%3Dyes Abstract: The aim of the present preliminary study was to describe a simple protocol for the analysis of the heart rate variability (HRV) that can reveal the different autonomic control between noncomplicated diabetic patients and normal subjects within 15 min. The power spectrum of the HRV was evaluated on 5-min-long electrocardiographic recordings in both the supine and the seated positions in 30 noncomplicated non-insulin-dependent diabetic (NIDDM) patients and in 30 healthy volunteers. In healthy subjects the low-frequency (LF) value was higher in seated position than in supine position, while in diabetic patients the LF value in seated position did not differ from that in supine position and did not differ from that in healthy subjects in supine position. The present work demonstrates... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360282 Sun, 01 Mar 2009 05:00:00 +0100 2360282 http://www.medworm.com/index.php?rid=2360281&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001390%2Fabstract%3Frss%3Dyes Conclusions: Hispanics have poorer access to care and poorer health status compared to Whites or Blacks. Controlling for socioeconomic and access to care variables eliminated disparities in self-management but did not eliminate disparities in quality of diabetes care. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360281 Sun, 01 Mar 2009 05:00:00 +0100 2360281 http://www.medworm.com/index.php?rid=2360280&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001316%2Fabstract%3Frss%3Dyes Conclusion: The nonreplication of association suggests differential genetic susceptibility of the two populations to diabetic chronic renal insufficiency. In the SI diabetic subjects, oxidative stress pathway genes might be an important predictor for the development of diabetic complications. Further, the association of wild-type alleles may suggest that they confer greater survival ability to comorbid complications and may be nephroprotective. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360280 Sun, 01 Mar 2009 05:00:00 +0100 2360280 http://www.medworm.com/index.php?rid=2360279&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001328%2Fabstract%3Frss%3Dyes Abstract: Aims: Insofar as hypertension is a risk factor for cardiovascular morbidity and mortality in Type 2 diabetes mellitus (T2DM), this study investigated the incidence of hypertension and associated risk factors in Saudi T2DM patients.Methods: A hospital-based, 11-year (1993–2004) prospective study of 916 adult originally normotensive T2DM Saudi patients (488 male and 428 female). T2DM was diagnosed as per World Health Organization (WHO) criteria, while hypertension was assessed according to the Seventh Joint National Criteria for Hypertension Classification (JNVII). Risk factors were analyzed on those who developed hypertension.Results: The hypertension incidence was 17.2/100 person-years, based on 2833.63 person-years of cohort group follow-up. Age-adjusted Cox regression coeffic... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360279 Sun, 01 Mar 2009 05:00:00 +0100 2360279 http://www.medworm.com/index.php?rid=2360278&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270800010X%2Fabstract%3Frss%3Dyes Conclusions: Our results suggested a close relationship between poor glycemic control and increased platelet activity in patients with type 2 DM. Furthermore, platelet activity recovered through improved glycemic control, which may prevent the possible role of platelets in cardiovascular events in these patients. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360278 Sun, 01 Mar 2009 05:00:00 +0100 2360278 http://www.medworm.com/index.php?rid=2360277&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000068%2Fabstract%3Frss%3Dyes Abstract: Purpose: To describe the frequency of orthostatic hypotension and hypertension and associations with risk factors in a cohort of persons with long-term Type 1 diabetes (n=440) participating in the Wisconsin Epidemiologic Study of Diabetic Retinopathy.Methods: Evaluations included detailed medical history, electrocardiography (ECG), and laboratory tests. Blood pressure (BP) was measured in supine and standing positions. Standing decrease in systolic (SBP) or diastolic (DBP) BP of at least 20 or 10 mmHg, respectively, was defined as orthostatic hypotension; increase of SBP from (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360277 Sun, 01 Mar 2009 05:00:00 +0100 2360277 http://www.medworm.com/index.php?rid=2360276&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001481%2Fabstract%3Frss%3Dyes We report the probability (Pr) of a rate decrease in the age-adjusted excess rate and considered the evidence strong if the probability was 0.90 or higher. Among men with diabetes, the evidence was strong for a probable decrease in excess rate for heart disease (8.7 per 1000 to 6.5), cerebrovascular disease (1.2 per 1000 to 0.75) and arterial disease (0.24 per 1000 to 0.08). Among women with diabetes, the evidence was strong for a probable decrease in excess rates for the overall (total) rate (17.8 per 1000 to 12.6), for heart disease (6.1 per 1000 to 4.4), IHD (4.4 per 1000 to 3.1), cerebrovascular disease (1.4 per 1000 to 0.5), arterial disease (0.17 per 1000 to 0.10) and cancer (2.1 per 1000 to 1.3) as underlying cause of death. The data reflect a high likelihood that cause-specific exc... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360276 Sun, 01 Mar 2009 05:00:00 +0100 2360276 http://www.medworm.com/index.php?rid=2360275&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000191%2Fabstract%3Frss%3Dyes (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2360275 Sun, 01 Mar 2009 05:00:00 +0100 2360275 http://www.medworm.com/index.php?rid=3308573&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270900004X%2Fabstract%3Frss%3Dyes Conclusions: The present meta-analysis showed an SMBG-related HbA1c reduction in non–insulin-treated type 2 diabetes patients that was similar to that in previous systematic reviews but in a substantially larger patient sample. This finding is consistent with most observational studies of similarly treated patients. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308573 Mon, 23 Feb 2009 00:00:00 +0100 3308573 http://www.medworm.com/index.php?rid=3308568&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872709000038%2Fabstract%3Frss%3Dyes We examined time trends in the use of health care services between diabetic and nondiabetic adults in Spain and their associations with sociodemographics variables.Research Design and Methods: Using data from two national health surveys, we estimated use of health care services, including hospital days per person-year, in the diabetic and nondiabetic populations in 1993 (n=20,880) and 2006 (n=29,478) in Spain.As the dependent variable, we took the answer to the questions, “Has used emergency medical services in the preceding year?” and/or “Have you been admitted to hospital in the preceding year?” Independent variables were age group, gender, educational level, and coexistence of chronic conditions.Results: Use of emergency medical services has been significantly incremented betwee... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3308568 Mon, 23 Feb 2009 00:00:00 +0100 3308568 http://www.medworm.com/index.php?rid=3058183&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708001086%2Fabstract%3Frss%3Dyes The objective of this study was to elucidate the role of inflammation in the resistance of retinopathy to arrest after termination of hyperglycemia. Streptozotocin-diabetic rats were (a) maintained either in poor glycemic control [PC group; glycated hemoglobin (GHb)>11%] or in good glycemic control (GC group; GHb (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3058183 Mon, 08 Dec 2008 00:00:00 +0100 3058183 http://www.medworm.com/index.php?rid=3058182&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708001098%2Fabstract%3Frss%3Dyes Conclusions: When compared with single position measurements, the modified orthostatic load protocol improves the sensitivity of short-term HRV examination. In well-controlled diabetic subjects without cardiovascular autonomic neuropathy (as excluded by standard cardiovascular reflex testing), the delayed recovery of LF band spectral power after orthostatic load with standing up indicates diminished parasympathetic activation. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3058182 Mon, 08 Dec 2008 00:00:00 +0100 3058182 http://www.medworm.com/index.php?rid=3058178&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708001104%2Fabstract%3Frss%3Dyes In this study, we examined for relationships between MMP and TIMP-1 and indices of arterial stiffness in subjects with T2DM.Research Design and Methods: A total of 60 subjects with T2DM and 60 nondiabetic subjects were recruited. Aortic distensibility (AD) was assessed noninvasively by ultrasonography and augmentation index by pulse wave analysis.Results: The values of AD were lower in subjects with T2DM than in controls (P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3058178 Mon, 08 Dec 2008 00:00:00 +0100 3058178 http://www.medworm.com/index.php?rid=3058184&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708001074%2Fabstract%3Frss%3Dyes This study aimed to determine the role of early and late glycation products in modulating inflammation in early diabetes.Materials: Sprague–Dawley rats (130–170 g) were injected with streptozotocin (75 mg/kg, ip) and treated with daily aminoguanidine (AG, 25 mg/kg, ip) or vehicle for 2 or 4 weeks.Methods: The base of a vacuum-induced blister raised on the hind paw was perfused with substance P (SP, 1 μM) and sodium nitroprusside (SNP, 100 μM). Changes in blood flow and plasma extravasation (PE) were measured. Amadori (1 mg/ml), advanced glycation end products (AGEs, 10 mg/ml), and anti-RAGE IgG (antibody against AGE receptors, 100 μg/ml) were individually perfused prior to SP.Results: In diabetic rats, responses to SNP and SP were reduced by 60% and 70%, respectively (P (Source: Jou... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3058184 Tue, 25 Nov 2008 00:00:00 +0100 3058184 http://www.medworm.com/index.php?rid=3058180&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000925%2Fabstract%3Frss%3Dyes Abstract: Objective: There are still considerable controversies regarding the basic pathophysiological mechanisms of impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT). The present study was undertaken to explore the β-cell function and insulin sensitivity in a Bangladeshi prediabetic population.Methods: Twenty-four IFG and 112 IGT subjects, along with 40 healthy controls, were selected purposively following 2003 ADA cut-off values and 2006 WHO/IDF grouping. IGT subjects were subcategorized into 53 isolated IGT (I-IGT) and 59 combined IFG-IGT subjects. Plasma glucose and insulin (by chemiluminescent immunoassay) were measured at fasting and 2 h after 75 g of oral glucose load. Insulin sensitivity was assessed by homeostasis model assessment (HOMA-S%) and insulin sensit... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3058180 Mon, 17 Nov 2008 00:00:00 +0100 3058180 http://www.medworm.com/index.php?rid=2952159&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000895%2Fabstract%3Frss%3Dyes Conclusion: The highness of insulin and c-peptide levels in the group that received treatment when compared to other groups and the lowness of oxidative markers such as SOD, catalase in this study can be explained by the fact that 1α,25(OH)2D3 treatment prevents the intervention of apoptosis mechanism. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2952159 Mon, 03 Nov 2008 00:00:00 +0100 2952159 http://www.medworm.com/index.php?rid=3058177&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000901%2Fabstract%3Frss%3Dyes Conclusions: DN can occur in the absence of other diabetes-related complications or comorbidities. The presence of DN and any other diabetes-related complications or comorbidities significantly increases health care charges. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3058177 Mon, 20 Oct 2008 00:00:00 +0100 3058177 http://www.medworm.com/index.php?rid=2952160&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000937%2Fabstract%3Frss%3Dyes Abstract: Charcot arthropathy (Charcot neuroarthropathy, diabetic neuropathic osteoarthropathy, or neuropathic arthropathy) remains a poorly understood disease, although recent research has improved our level of knowledge regarding its etiology and treatment. The effects of Charcot arthropathy are almost exclusively seen in the foot and ankle, and the diagnosis is commonly missed upon initial presentation. It has been well established that this complication of diabetes mellitus severely reduces the overall quality of life and dramatically increases the morbidity and mortality of patients. However, there are few high-level evidence studies to support management and treatment options at this point in time. The goal of this study is to evaluate the modern concepts of Charcot arthropathy throu... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2952160 Mon, 20 Oct 2008 00:00:00 +0100 2952160 http://www.medworm.com/index.php?rid=2952155&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000913%2Fabstract%3Frss%3Dyes Abstract: Aim: The aim of this study was to compare the efficacy of glimepiride/metformin combination versus glibenclamide/metformin for reaching glycemic control in patients with uncontrolled type 2 diabetes mellitus.Patients and Methods: A randomized, double-blind, multicenter clinical trial was performed in 152 uncontrolled type 2 diabetic patients. Serum fasting and postprandial glucose, hemoglobin A1c (A1C), high-density lipoprotein cholesterol, and triglycerides were measured. After random allocation, all patients received two pills of glimepiride (1 mg)/metformin (500 mg) or glibenclamide (5 mg)/metformin (500 mg) po once a day. Dosage was increased to a maximum of four pills in order to reach the glycemic control goals (fasting glucose ≤7.2 mmol/l, postprandial glucose (Source: J... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2952155 Mon, 13 Oct 2008 00:00:00 +0100 2952155 http://www.medworm.com/index.php?rid=3058176&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000706%2Fabstract%3Frss%3Dyes Conclusion: TNFα and IL-8 play a significant role in the proatherogenic activity of monocytes in Type 2 diabetes. The TNFα-connected activity of monocytes may directly determine endothelial dysfunction and injury. The location of atherosclerosis should be taken into account in the assessment of the proinflammatory activity of peripheral blood monocytes. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3058176 Mon, 06 Oct 2008 00:00:00 +0100 3058176 http://www.medworm.com/index.php?rid=3058179&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000883%2Fabstract%3Frss%3Dyes Abstract: Objectives: Increased urinary orosomucoid excretion rate (UOER) independently predicted cardiovascular mortality in patients with type 2 diabetes at 5-years of follow-up. To further explore UOER in relation to local renal physiological phenomena, we studied renal glomerular and tubular functions in patients with type 2 diabetes and normal or increased UOER.Methods: We performed a cross-sectional study of 40 patients with type 2 diabetes (normal UOER, n=16; increased UOER, n=24) who displayed no signs of cardiovascular disease and 21 healthy control persons. The renal clearance values of [51Cr]ethylenediaminetetraacetic acid ([51Cr]EDTA), lithium, orosomucoid, albumin, and sodium were measured.Results: Patients with type 2 diabetes had normal glomerular filtration rate (GFR) measu... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=3058179 Fri, 26 Sep 2008 00:00:00 +0100 3058179 http://www.medworm.com/index.php?rid=2952161&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270800072X%2Fabstract%3Frss%3Dyes Abstract: Diabetes mellitus (DM) is a metabolic disorder that requires medical diagnosis and treatment. Type 2 DM is due to a combination of defective secretion of and responsiveness to insulin. In early stages, the predominant abnormality is reduced insulin sensitivity, and hyperglycemia can be reversed by a variety of measures and medications. In this stage, the cornerstone of glucose-lowering therapy is lifestyle modification, but when counseling does not adequately achieve the recommended glycemic targets, at least five classes of oral drugs are available. In general, α-glucosidase inhibitors delay carbohydrate absorption, metiglinides and sulfonylureas increase insulin supply, and biguanides and thiazolidinediones enhance insulin action.Given the high cardiovascular morbidity and mor... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2952161 Wed, 03 Sep 2008 00:00:00 +0100 2952161 http://www.medworm.com/index.php?rid=2952157&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000718%2Fabstract%3Frss%3Dyes Conclusion: PAI-1 levels are independently related to CAC in younger Type 1 diabetes participants. PAI-1 levels were not independently related to CAC in non-diabetes participants. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2952157 Wed, 03 Sep 2008 00:00:00 +0100 2952157 http://www.medworm.com/index.php?rid=2754185&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000731%2Fabstract%3Frss%3Dyes Conclusions: In this analysis, the safety of duloxetine in patients with DPNP was not found to be significantly different between patients with and without historical or comorbid CV conditions. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2754185 Tue, 02 Sep 2008 23:00:00 +0100 2754185 http://www.medworm.com/index.php?rid=2952163&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000688%2Fabstract%3Frss%3Dyes Abstract: Spontaneous diabetic myonecrosis is a rare complication of diabetes mellitus. It involves mostly the thigh and calf muscles. It presents with acute leg pain, without any evidence of systemic illness. Diagnosis can be difficult and delayed. Here, we report a case of a 65-year-old man presenting with this complication. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2952163 Thu, 07 Aug 2008 00:00:00 +0100 2952163 http://www.medworm.com/index.php?rid=2952158&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270800069X%2Fabstract%3Frss%3Dyes Conclusions: The overall prevalence of cardiovascular risk factors and unhealthy lifestyle behaviors among diabetes patients has shown no improvement in the decade 1993–2003, and there have been significant setbacks, in particular the rise in obesity and HBP. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2952158 Thu, 07 Aug 2008 00:00:00 +0100 2952158 http://www.medworm.com/index.php?rid=2754177&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000548%2Fabstract%3Frss%3Dyes Conclusion: There is a notable linear correlation between the endothelial cytotoxicities of Glu and its concentrations. The spinodal point concentration of statistical significance of hyperglycemia cytotoxicity is 22.2 mmol/l; 1/300 Dan Gua can reverse the endothelia cytotoxicity in different concentrations of hyperglycemia. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2754177 Sun, 27 Jul 2008 23:00:00 +0100 2754177 http://www.medworm.com/index.php?rid=2952162&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000524%2Fabstract%3Frss%3Dyes Abstract: A 27-year-old male, who had developed diabetes mellitus type 1 (DMT1) since the age of eighteen and alopecia areata universalis nine months later, attended the outpatient clinics complaining of general fatigue and shortness of breath. A Schilling test was indicative of pernicious anemia. Antigastric parietal cell (AGPA) and anti-intrinsic factor antibodies were positive, confirming diagnosis of pernicious anemia. Thyroid and Addison's disease were excluded. Gastroscopy revealed atrophic gastritis without any evidence of carcinoid tumors. The aim of this case, which, to our knowledge, is the first one to describe a correlation between diabetes mellitus Type 1 (DMT1), pernicious anaemia, and alopecia areata universalis, is to remind the clinician of the increased risk of pernicious... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2952162 Wed, 09 Jul 2008 00:00:00 +0100 2952162 http://www.medworm.com/index.php?rid=2952154&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000500%2Fabstract%3Frss%3Dyes Conclusions: Although Latinos and Blacks of comparable age and glycemic control are equally at risk for CSME and proliferative retinopathy, Latinos may be at greater risk for a specific phenotype of DR characterized by extravasation of intraretinal hemorrhages, which is associated with poor prognosis. Further prospective studies may uncover racial differences that may have implications for prognosis and therapy. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2952154 Fri, 04 Jul 2008 00:00:00 +0100 2952154 http://www.medworm.com/index.php?rid=2754186&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000512%2Fabstract%3Frss%3Dyes We report herein a case of a diabetic foot ulcer that was treated with integrated traditional Chinese and Western medicine, with desirable cost-effective results. Traditional Chinese medicine (TCM) therapeutic principles include improving the spleen, nourishing yin, regulating qi, and resolving dampness, as well as activating stagnant blood. Western medicine includes wound debridement, skin grafting, and use of insulin, antibiotics, and vasodilators. The patient was treated with a holistic multidisciplinary approach (i.e., a combination of TCM and Western medicine, surgical management, education for diabetic foot care, and psychological counseling). Without this approach, the patient might have ended up with foot amputation and/or sepsis. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2754186 Thu, 03 Jul 2008 23:00:00 +0100 2754186 http://www.medworm.com/index.php?rid=2489364&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000536%2Fabstract%3Frss%3Dyes Conclusions: The present study thus provides the first evidence that SNP −11377C/G alters the sequence in one of the SP1 binding sites in the adiponectin promoter region. This polymorphism, together with another promoter SNP −11391G/A, may confer susceptibility to the development of DN in T1D patients among the GoKinD population. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2489364 Thu, 03 Jul 2008 23:00:00 +0100 2489364 http://www.medworm.com/index.php?rid=2754187&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000494%2Fabstract%3Frss%3Dyes Abstract: Aim of the Study: The aim of this study was to evaluate reverse volumetric left ventricular (LV) remodeling after cardiac resynchronization therapy (CRT) in patients with heart failure (HF) with vs. without diabetes mellitus (DM).Methods: The study comprised 130 consecutive patients with HF (mean age, 61±12 years) who underwent CRT. Thirty patients (23%) had DM [mean glycated haemoglobin (HbA1c), 7.2±3.4%; 13 (43%) on insulin therapy]. Echocardiography, including tissue Doppler measurements, was performed before CRT and between 3 and 6 months after CRT. Echocardiographic response was defined as a >15% reduction in LV end-systolic volume (ESV).Results: Patients with DM had more often hypertension (60% vs. 29%, P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2754187 Mon, 23 Jun 2008 23:00:00 +0100 2754187 http://www.medworm.com/index.php?rid=2754182&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000482%2Fabstract%3Frss%3Dyes Conclusion: All persons with hypertension, irrespective of age, sex, and BMI, are at elevated risk of developing diabetes. Men and women with hypertension who are overweight or obese are at substantially elevated risk of diabetes, regardless of age, and should be monitored especially closely for the development of this disease. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2754182 Mon, 02 Jun 2008 23:00:00 +0100 2754182 http://www.medworm.com/index.php?rid=2754184&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000470%2Fabstract%3Frss%3Dyes Abstract: Background: Advanced glycation end products (AGE) have been reported to contribute to aging and cataract formation in the lens. In the present study, AGE immunoreactivity in human serum samples of normal senile subjects (n=31), senile diabetic patients without cataract (n=33), senile diabetic patients with cataract (n=30), senile nondiabetic with cataract (n=30), and normal young subjects (n=31) was investigated.Methods: A noncompetitive ELISA with polyclonal anti-AGE antibody was performed. The patients were selected on clinical grounds from Eye Ward, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.Results: Fasting blood glucose, glycosylated hemoglobin, and serum fructosamine were estimated. Fasting blood glucose, HbA1C, and serum fructosamine levels were significantly (P... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2754184 Tue, 27 May 2008 23:00:00 +0100 2754184 http://www.medworm.com/index.php?rid=2489358&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000354%2Fabstract%3Frss%3Dyes Conclusions: We may observe a decrease in the prevalence of DR, overt nephropathy, and blindness in Type 1 and 2 patients and a decrease in the prevalence of microalbuminuria only in Type 2 patients. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2489358 Thu, 24 Apr 2008 23:00:00 +0100 2489358 http://www.medworm.com/index.php?rid=2489361&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000317%2Fabstract%3Frss%3Dyes Abstract: Background and Aim: Diabetes mellitus (DM) is recognized as an important risk factor for stroke and might theoretically influence post-stroke level of disability, increasing the extension of the cerebral injured area. However, results of the few researches aimed at studying this influence are contradictory; moreover, the effect of DM on motor recovery has not been extensively studied. The aim of this study was to investigate the effect of DM on both functional and motor recovery.Methods: A total of 395 acute patients with first stroke were selected in a rehabilitation department and divided into two groups on the basis of the presence or absence of DM (DM+ and DM−, respectively). Outcome measures were the Barthel Index, the Fugl-Meyer Assessment Scale, and the mobility part of ... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2489361 Wed, 16 Apr 2008 23:00:00 +0100 2489361 http://www.medworm.com/index.php?rid=2754181&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000330%2Fabstract%3Frss%3Dyes We report a comparison of fundus photographs and ophthalmologic examination at baseline, permitting an evaluation of multiple settings similar to common clinical practice.Research Design and Methods: A 340-patient subset had both local dilated fundus examinations and centrally read seven-field stereo fundus photographs completed within 60 days of each other (median 28 days). Local examiners were unaware of the stereo photographs.Results: Overall, agreement within one step was 76% and exact agreement between ophthalmoscopy and central gradings of fundus photographs on a five-step retinopathy severity scale was 43% (weighted kappa 0.42, CI 0.35–0.48). In about 90% of disagreements the severity level was higher by photographic grading. The sensitivity for ophthalmoscopy compared to grading ... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2754181 Sun, 13 Apr 2008 23:00:00 +0100 2754181 http://www.medworm.com/index.php?rid=2952156&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000287%2Fabstract%3Frss%3Dyes Conclusions: The initial decrease of the insulin serum concentration during short-term intense exercise in normal middle-aged men is primarily related to the increased clearance of the hormone. Normal insulin response to the exercise was abolished in Type 2 diabetic patients treated with gliclazide. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2952156 Fri, 04 Apr 2008 00:00:00 +0100 2952156 http://www.medworm.com/index.php?rid=2754179&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000329%2Fabstract%3Frss%3Dyes Conclusion: Significant decline in apoptosis, lipid peroxidation, protein oxidation, and QT interval resulted from vitamin E administration, which strongly implies that this radical scavenger may promote a convalescing effect on diabetic cardiomyopathy through the attenuation of oxidative stress and abrogation of apoptotic signals, which was verified by restoring normal QT interval. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2754179 Thu, 03 Apr 2008 23:00:00 +0100 2754179 http://www.medworm.com/index.php?rid=2754178&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000275%2Fabstract%3Frss%3Dyes Abstract: The aim of this cross-sectional study was to determine the significant limitations, sensitivity, specificity, partial correlations, and odds ratios of nutrient intake in patients with and without hypertension with Type 2 diabetes mellitus.Diabetic patients (n=220) with clinical diagnosis of hypertension and diabetic patients (n=230) without hypertension were included in this study. The questionnaire form included a list of 65 food items formed from five main food groups (grain, meat and alternatives, dairy products, vegetables–fruits and fat) and 25 dietary habits.When both groups were compared and analyzed by logistic regression, black tea consumption (OR=0.823, P (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2754178 Thu, 03 Apr 2008 23:00:00 +0100 2754178 http://www.medworm.com/index.php?rid=2754183&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000093%2Fabstract%3Frss%3Dyes Conclusion: Urine TBARS, RCDs, and TSHGs could be proposed as possible markers for oxidative damage of kidney in DN. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2754183 Tue, 25 Mar 2008 00:00:00 +0100 2754183 http://www.medworm.com/index.php?rid=2754180&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270800007X%2Fabstract%3Frss%3Dyes Abstract: Objective: The aim of this study was to describe the prevalence of cardiovascular disease risk factors (CVDRFs) and the degree of control in a Spanish population of patients with type 1 diabetes (DM1) and end-stage renal disease (ESRD) as well as the changes observed in this setting over 8 years.Design and Methods: Patients with DM1 and ESRD were evaluated from 1999 to 2006. Clinical variables, smoking habit, glycosylated hemoglobin (HbA1c) and lipids values, and drug treatment were evaluated. The cohort was divided into four biannual groups for analysis. HbA1c >7, LDL >100 mg/dl, blood pressure (BP) >140/90 mmHg, and tobacco use were considered as CVDRFs.Results: A total of 177 patients (65% male) with a mean age of 37.2±6.2 years were studied. They had 24.3±5.9 years of diabe... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2754180 Tue, 25 Mar 2008 00:00:00 +0100 2754180 http://www.medworm.com/index.php?rid=2489366&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000081%2Fabstract%3Frss%3Dyes Abstract: Cerebrovascular disease (CeVD) represents a major cause of morbidity and mortality worldwide. Diabetes mellitus (DM) represents an independent risk factor for CeVD. The aim of the present review is to describe the epidemiology of CeVD in patients with DM and to explain how DM and diabetic autonomic neuropathy can increase the risk of CeVD. The prevention and management of CeVD in the diabetic population are also analyzed. (Source: Journal of Diabetes and Its Complications) Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2489366 Tue, 25 Mar 2008 00:00:00 +0100 2489366 http://www.medworm.com/index.php?rid=2489365&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872707001511%2Fabstract%3Frss%3Dyes Abstract: Diabetes mellitus is a powerful risk factor for cardiovascular disease associated with high morbidity and mortality rates. Diabetic patients also have an increased incidence of heart failure which has been traditionally attributed to the concurrent presence of ischemic or hypertensive heart disease. Yet, nowadays, according to recent scientific evidence, diabetic myocardial disease (DMD) is more and more being considered as a distinct nosologic entity, independent of the co-existence of coronary artery disease, arterial hypertension or other risk factors, with the potential to lead to a self-existent progressive development of heart failure.In this article, we review the possible pathophysiologic mechanisms involved in the development of DMD as well as the structural and function... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2489365 Fri, 14 Mar 2008 00:00:00 +0100 2489365 http://www.medworm.com/index.php?rid=2489363&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000032%2Fabstract%3Frss%3Dyes Abstract: Objective: Both diabetes and hemodialysis (HD) are associated with increased oxidative stress. The aim of this study was to clarify the effect of maintenance HD on oxidative stress parameters in diabetic patients and to explore any relation between carotid artery intima-media thickness (CIMT) and oxidative stress markers.Methods: Twenty Type 2 diabetic patients undergoing chronic maintenance HD, 20 type 2 diabetic patients with normal renal function, and 20 age- and sex-matched healthy subjects were included. Serum thiobarbituric acid reactive substances (TBARS), protein carbonyl content (PCO), and nitrite/nitrate levels were determined as oxidative stress markers. Serum vitamin E, plasma sulfhydryl (P-SH), erythrocyte glutathione (GSH) levels, and superoxide dismutase (SOD), cat... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2489363 Fri, 14 Mar 2008 00:00:00 +0100 2489363 http://www.medworm.com/index.php?rid=2489360&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS105687270700150X%2Fabstract%3Frss%3Dyes Abstract: Purpose: To evaluate the correlation of lipid profile and clinical presentation of macular edema in Type 2 diabetes mellitus (DM) patients.Materials and Methods: The study included 20 patients with chronic diabetic macular edema and plaque-like hard exudates (Group 1), 20 patients with diabetic macular edema (Group 2), and 20 DM patients but without retinopathy (Group 3). Diabetic retinopathy was classified according to the Early Treatment Diabetic Retinopathy Study grading system. Sample t test was used to evaluate the association between the fasting serum lipid [total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL)], glycosylated hemoglobin (HbA1c), fasting blood glucose, creatinine levels, and the clinical findings. P values (Source: Jo... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2489360 Fri, 14 Mar 2008 00:00:00 +0100 2489360 http://www.medworm.com/index.php?rid=2489359&cid=s_38505_15_f&fid=38505&url=http%3A%2F%2Fwww.jdcjournal.com%2Farticle%2FPIIS1056872708000020%2Fabstract%3Frss%3Dyes Abstract: Objective: Few studies have investigated the effect of type of diets on GLP-1 concentrations. The aim of this study was to compare the effect of two diets on circulating GLP-1 levels and the relation with insulin response after weight loss.Methods: A population of 118 obese patients were analyzed. Patients were randomly allocated to two groups: (a) Diet I (low carbohydrate) and (b) Diet II (low fat). Biochemical and anthropometric parameters were measured before and after 3 months of hypocaloric diet.Results: Fifty-two patients (12 male/40 female) were treated with Diet I and 66 patients (21 male/45 female) with Diet II. In Group I, basal GLP-1 levels did not change after dietary treatment (9.4±3.3 vs. 9.9±3.1 ng/ml; ns). In Group II, GLP-1 levels decreased significantly (8.4%)... Journal of Diabetes and Its Complications journals http://www.medworm.com/rss/comments.php?id=2489359 Fri, 14 Mar 2008 00:00:00 +0100 2489359