MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Experimental and Clinical Cancer Research' source. Sat, 20 Mar 2010 13:50:41 +0100 http://www.medworm.com/index.php?rid=3360393&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F25 Conclusion: Ki 67 index is not use-full prognostic marker for aggressive type of giant cell tumor of the bone. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3360393 Fri, 12 Mar 2010 00:00:00 +0100 3360393 http://www.medworm.com/index.php?rid=3351523&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F24 Conclusions: Cholangiocarcinoma's increasing worldwide incidence is especially poignant in view of both the lacking effective therapies, and the fact that it is commonly diagnosed in advanced stages. As CCA neural invasion often appears early, more complete characterization of its molecular pathology could lead to the identification of targets for the diagnosis and therapy of this devastating malignancy. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3351523 Wed, 10 Mar 2010 00:00:00 +0100 3351523 http://www.medworm.com/index.php?rid=3347764&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F22 Conclusions: Our results indicated that thiazolidinediones enhance VEGF and neuropilin-1 expression and induce the inhibition of cell growth. We propose the existence of a pathway for arresting cell growth that involves the interaction of thiazolidinedione-induced VEGF and neuropilin-1 in NSCLC. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3347764 Wed, 10 Mar 2010 00:00:00 +0100 3347764 http://www.medworm.com/index.php?rid=3347763&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F23 Conclusion: These data suggest that ChA21 inhibits the growth and induces apoptosis of SK-OV-3 via regulating the balance between Bax and Bcl-2. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3347763 Wed, 10 Mar 2010 00:00:00 +0100 3347763 http://www.medworm.com/index.php?rid=3340343&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F21 Conclusion: This is the first study providing a simultaneous evaluation of the anti-neoplastic action of TRD across several malignant cell lines. The involvement of ROS and caspase activation was highly variable among the five cell lines, although all were susceptible to TRD induced cell death. Our results indicate, that TRD is likely to provide multifaceted cell death mechanisms leading to a cell line specific diversity. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3340343 Sun, 07 Mar 2010 00:00:00 +0100 3340343 http://www.medworm.com/index.php?rid=3323787&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F20 Conclusions: The number of new patients arising in Shanghai increased from 2001 to 2006. There were still patients receiving hydroxyurea and IFN-alpha. As the first-line regime for CML, imatinib was less administered in Shanghai before, but has received considerable development and great responses since 2003. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3323787 Wed, 03 Mar 2010 00:00:00 +0100 3323787 http://www.medworm.com/index.php?rid=3323788&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F19 Gastroenteropancreatic neuroendocrine tumours (GEP NETs) are rare tumours that present many clinical features.They secrete peptides and neuroamines that cause distinct clinical syndromes, including carcinoid syndrome. However, many are clinically silent until late presentation with mass effects.In 2000 the WHO developed a new classification which gives a better description of the characteristics and biological behaviour of the tumour.Surgical resection is the treatment of first choice for a patient with a GEP NET. In metastatic disease multiple therapeutic approaches are possible. In these cases the goal is to improve quality of life and to extent survival.GEP NETs express somatostatin receptors (SSTRs), which are bound by somatostatin (SST) or its synthetic analogues, although the subtype... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3323788 Tue, 02 Mar 2010 00:00:00 +0100 3323788 http://www.medworm.com/index.php?rid=3319221&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F18 Conclusions. C282Y mutation was associated with HCC in European alcoholic LC patients. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3319221 Tue, 02 Mar 2010 00:00:00 +0100 3319221 http://www.medworm.com/index.php?rid=3303683&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F17 Conclusions: Coronin-1C could be a candidate biomarker to predict HCC invasive behavior. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3303683 Wed, 24 Feb 2010 00:00:00 +0100 3303683 http://www.medworm.com/index.php?rid=3299558&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F15 Conclusion: There were no interactions between GEM and S-1 regarding plasma PK of GEM and 5-FU. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3299558 Wed, 24 Feb 2010 00:00:00 +0100 3299558 http://www.medworm.com/index.php?rid=3299557&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F16 Conclusions: The expression of CXCR4, CCR7, and EGFR may be associated with LN metastasis. Moreover, the expression of these receptors can serve as an indicator of undesirable prognosis in patients with breast cancer. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3299557 Wed, 24 Feb 2010 00:00:00 +0100 3299557 http://www.medworm.com/index.php?rid=3299559&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F14 Conclusion: The abnormal expressions of Bcl-xs and Bcl-xl were one of the molecular mechanisms for the pathogenesis of endometrial carcinoma, and altered ratio between these two might involve in the onset of endometrial carcinoma. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3299559 Tue, 23 Feb 2010 00:00:00 +0100 3299559 http://www.medworm.com/index.php?rid=3277127&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F13 Conclusions: These results suggest a potential new clinical strategy for MM gene treatment. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3277127 Tue, 16 Feb 2010 00:00:00 +0100 3277127 http://www.medworm.com/index.php?rid=3263935&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F12 Conclusion: IP6 + Inositol as an adjunctive therapy is valuable help in ameliorating the side effects and preserving quality of life among the patients treated with chemotherapy. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3263935 Fri, 12 Feb 2010 00:00:00 +0100 3263935 http://www.medworm.com/index.php?rid=3260285&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F11 Conclusion: Although the mouse model does not exactly match the human disease, it will be suited for tests of new substances for the treatment of the Sezary syndrome. The formation of an isolated tumor on the skin has the advantage that the effect of a potential drug can be directly monitored without the use of invasive methods. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3260285 Thu, 11 Feb 2010 00:00:00 +0100 3260285 http://www.medworm.com/index.php?rid=3256002&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F10 SIAH proteins are the human members of an highly conserved family of E3 ubiquitin ligases. Several data suggest that SIAH proteins may have a role in tumor suppression and apoptosis. Previously, we reported that SIAH-1 induces the degradation of Kid (KIF22), a chromokinesin protein implicated in the normal progression of mitosis and meiosis, by the ubiquitin proteasome pathway. In human breast cancer cells stably transfected with SIAH-1, Kid/KIF22 protein level was markedly reduced whereas, the Kid/KIF22 mRNA level was increased. This interaction has been further elucidated through analyzing SIAH and Kid/KIF22 expression in both paired normal and tumor tissues and cell lines. It was observed that SIAH-1 protein is widely expressed in different normal tissues, and in cells lines but showing... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3256002 Tue, 09 Feb 2010 00:00:00 +0100 3256002 http://www.medworm.com/index.php?rid=3205723&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F9 In this study we evaluated the adverse effects at least 3 years post an accelerated hypofractionated whole breast radiotherapy schedule. Methods: From October 2004 to March 2006, 39 consecutive patients aged over 18 years with pTis, pT1-2, pN0-1 breast adenocarcinoma who underwent conservative surgery were treated with an adjuvant accelerated hypofractionated radiotherapy schedule consisting of 34 Gy in 10 daily fractions over 2 weeks to the whole breast, followed after 1 week by an electron boost dose of 8 Gy in a single fraction to the tumour bed. Skin and lung radiation toxicity was evaluated daily during therapy, once a week for one month after radiotherapy completion, every 3 months for the first year and from then on every six months. In particular lung toxicity was investigated in t... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3205723 Mon, 25 Jan 2010 00:00:00 +0100 3205723 http://www.medworm.com/index.php?rid=3199013&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F8 Conclusions: Our findings, for the first time, unify the current inconsistent findings for bortezomib treatment and survivin expression, and linked the effect of bortezomib on survivin expression, apoptosis induction and bortezomib resistance in the relationship with p53 status, which is independent of cancer cell types. Further mechanistic studies along with this line likely impact the optimal clinical use of bortezomib in cancer therapeutics. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3199013 Fri, 22 Jan 2010 00:00:00 +0100 3199013 http://www.medworm.com/index.php?rid=3194995&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F6 In this study, we investigate differential gene expression, especially the expression of decorin, EGFR and cyclin D1, during mammary gland epithelial cell carcinogenesis in TA2 mice. Methods: Gene expression profiles of spontaneous breast cancer and matched normal mammary gland tissues in TA2 mice were ascertained using an Affymetrix Mouse 430 2.0 array. Twelve mammary tissue samples from five month-old female TA2 mice (Group A), as well as 28 samples from mammary (Group B) and cancer tissues (Group C) of spontaneous breast cancer-bearing TA2 mice, were subsequently used to detect the expression of decorin, EGFR and cyclin D1 by real-time PCR and immunohistochemical methods. Results: Several imprinted genes, oncogenes and tumor suppressor genes were differentially expressed between normal ... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3194995 Fri, 22 Jan 2010 00:00:00 +0100 3194995 http://www.medworm.com/index.php?rid=3194996&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F5 Conclusion: In uterine cancers, H&E, serial sectioning and IHC appears the best histological combined technique to detect micrometastases. Although accumulating data have proved the relation between the risk of recurrence and the presence of micrometastases, their clinical implications on indications for adjuvant therapy has to be clarified. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3194996 Thu, 21 Jan 2010 00:00:00 +0100 3194996 http://www.medworm.com/index.php?rid=3182905&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F4 Conclusion: The present endometriosis model would be useful for investigation of the mechanisms of angiogenesis process involved in the peritoneal attachment of endometrial cells, as well as of the effects of therapeutic drugs, particularly with antiangiogenic activity. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3182905 Tue, 19 Jan 2010 00:00:00 +0100 3182905 http://www.medworm.com/index.php?rid=3168598&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F2 Conclusions: Cytoplasmic myosin VI immunopositivity and nuclear beta-catenin immunostaining were associated with lower Fuhrman grades, and there was a strong positive relationship between E-cadherin immunostaining and beta-catenin immunostaining in RCCs. Cytoplasmic myosin VI immunostaining was associated with poorer prognosis in RCCs. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3168598 Thu, 14 Jan 2010 00:00:00 +0100 3168598 http://www.medworm.com/index.php?rid=3168597&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F3 Conclusion: To our knowledge, this is the first description of a role for connexin 43 in the inhibition of U251 growth using Ad-bFGF-siRNA. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3168597 Thu, 14 Jan 2010 00:00:00 +0100 3168597 http://www.medworm.com/index.php?rid=3138025&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F29%2F1%2F1 Conclusion: The results indicate that IBM-BMT administration of a replication defective adenovirus is a feasible mode of delivery, allowing exogenous transference. The findings in this study are conducted for the future long-term studies of safety assessment of Ad-EGFP-MDR1. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3138025 Mon, 04 Jan 2010 00:00:00 +0100 3138025 http://www.medworm.com/index.php?rid=3130573&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F160 We examined the expression profile and methylation status of RASSF1A in two NPC cell lines, 38 primary nasopharyngeal carcinoma and 14 normal nasopharyngeal epithelia using RT-PCR and methylated specific PCR(MSP) respectively. 5-aza-dC was then added to confirm the correlation between hypermethylation status and inactivation of RASSF1A. The NPC cell line CNE-2 was transfected with exogenous pcDNA3.1(+)/RASSF1A plasmid in the presence or absence of mutated K-Ras by liposome-mediated gene transfer method. Flow cytometry was used to examine the effect of RASSF1A on cell cycle modulation and apoptosis. Meanwhile, trypan blue dye exclusion assay was used to detect the effect of RASSF1A transfection alone and the co-transfection of RASSF1A and K-Ras on cell proliferation. Results: Promoter methy... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3130573 Wed, 30 Dec 2009 00:00:00 +0100 3130573 http://www.medworm.com/index.php?rid=3122765&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F159 Background: The results from the published studies on the association between hypoxia-inducible factor -1alpha (HIF-1alpha) polymorphisms and cancer risk are conflicting. In this meta-analysis, we aimed to investigate the association between HIF-1alpha 1772 C/T and 1790 G/A polymorphisms and cancer. Methods: The meta-analysis for 1772 C/T polymorphism included 4131 cancer cases and 5387 controls, and for 1790 G/A polymorphism included 2058 cancer cases and 3026 controls. Allelic and genotypic comparisons between cases and controls were evaluated. Subgroup analyses by cancer types, ethnicity, and gender were also performed. We included prostate cancer in male subgroup, and female specific cancers in female subgroup. Results: For the 1772 C/T polymorphism, the analysis showed that the T alle... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3122765 Sun, 27 Dec 2009 00:00:00 +0100 3122765 http://www.medworm.com/index.php?rid=3107364&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F157 Conclusion: The description of this sample shows: general overestimation of the risk, inaccurate perception compared to BRCApro calculation and a more accurate estimation in those subjects with more cancer affected relatives (high risk subjects). No correlation was found between the levels of perception of risk and anxiety and depression.Based on our findings, it is worth pursuing improved communication strategies about the actual cancer and genetic risk, especially for subjects at "intermediate and slightly increased risk" of developing an hereditary breast and/or ovarian cancer or of being mutation carrier. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3107364 Mon, 21 Dec 2009 00:00:00 +0100 3107364 http://www.medworm.com/index.php?rid=3102718&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F156 Conclusions: Together with other results, these results reveal that CENP-E expression was reduced in human HCC tissue, and low CENP-E expression result in aneuploidy in LO2 cells. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3102718 Fri, 18 Dec 2009 00:00:00 +0100 3102718 http://www.medworm.com/index.php?rid=3090248&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F155 Bladder cancer is the ninth most common malignancy in the world. Successful clinical management remains a challenge. In order to search for novel targeted and efficacious treatment, we sought to investigate anti-tumor activity of BI-TK suicide gene therapy system in a rat model of bladder tumors. We first constructed and tested an anaerobic Bifidobacterium infantis-mediated thymidine kinase (BI-TK) suicide gene therapy system. To test the in vivo efficacy of this system, we established a rat model of bladder tumors, which was induced by N-methyl-nitrosourea perfusion. Bifidobacterium infantis containing the HSV-TK (i.e., BI-TK) were constructed by transformation of recombinant plasmid pGEX - TK. The engineered BI-TK was injected into tumor-bearing rats via tail vein, followed by intraperit... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3090248 Wed, 16 Dec 2009 00:00:00 +0100 3090248 http://www.medworm.com/index.php?rid=3085939&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F154 Conclusions: Increased expression of Lewis y antigen plays an important role in promoting cell proliferation through activating PI3K/Akt signaling pathway in ovarian carcinoma-derived RMG-I cells. Inhibition of Lewis y expression may provide a new therapeutic approach for Lewis y positive ovarian cancer. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3085939 Tue, 15 Dec 2009 00:00:00 +0100 3085939 http://www.medworm.com/index.php?rid=3083491&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F153 Conclusion: ERCC2 751 polymorphism may be a genetic risk modifier for lung adenocarcinoma in non-smoking females in China. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3083491 Mon, 14 Dec 2009 00:00:00 +0100 3083491 http://www.medworm.com/index.php?rid=3083492&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F152 Background: mTOR signaling pathway and its downstream serine/threonine kinase p70S6k were frequently activated in human cancers. The dysregulation of the mTOR pathway has been found to be a contributing factor of a variety of different cancer. To investigate the role of mTOR signal pathway in the stepwise development of gastric carcinomas, we analyzed the correlations between the mTOR and P70S6K expression and clinic pathological factors and studied its prognostic role in gastric carcinomas. Methods: mTOR and phospho-p70S6K proteins were examined by immunohistochemistry on tissue microarray containing gastric carcinomas (n=412), adenomas (n=47) and non-neoplastic mucosa (NNM, n=197) with a comparison of their expression with clinicopathological parameters of carcinomas. Results: There was ... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3083492 Sun, 13 Dec 2009 00:00:00 +0100 3083492 http://www.medworm.com/index.php?rid=3080374&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F151 Conclusions: Data presented in this work show that PD166866 has clear antiproliferative effects. The negative control of cell proliferation may be exerted through the activation of the apoptotic pathway. The results of experiments addressing this specific point, such as: evaluation of DNA damage, lipoperoxidation of the cell membrane and increase of expression of PARP, an enzyme directly involved in DNA repair. Results suggest that cells exposed to PD16866 undergo apoptosis. However, concomitant modes of cell death cannot be ruled out. The possible use of this drug for therapeutic purposes is discussed. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3080374 Fri, 11 Dec 2009 00:00:00 +0100 3080374 http://www.medworm.com/index.php?rid=3076775&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F150 Conclusions: Through this research, we are trying to find novel functional genes that are mediated by HIF-1alpha and provide the theoretical basis for new therapeutic targets. HIF-1 alpha maybe upregulate the expression of SOCS1 through mediation of STAT3 and IL-6. In addition, SOCS1 could significantly induce apoptosis and suppress growth of NCI-H446 cells. This was contrary to HIF-1alpha and it indicated that there might be an antagonism effect between HIF-1alpha and SOCS1 on regulating growth and apoptosis of NCI-H446 cells. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3076775 Thu, 10 Dec 2009 00:00:00 +0100 3076775 http://www.medworm.com/index.php?rid=3072706&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F148 Conclusion: CCU may allow an early and noninvasive detection of CBTs and hence safer operations. The combined use of CCU and SRS-SPECT provide useful data to identify those tumours and to evaluate their extent and carotid arteries infiltration. Radioisotope imaging is a sensitive modality to detect metastases and lymph node involvement that are markers of CBT malignancy. After surgery CCU and SRS-SPECT can be accurate modalities for surveillance for an early detection of CBTs recurrence. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3072706 Thu, 10 Dec 2009 00:00:00 +0100 3072706 http://www.medworm.com/index.php?rid=3072704&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F149 Conclusions: The classification performance of LDA modification methods was superior to that of traditional LDA with respect to the average error and there was no significant difference between theses modification methods. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3072704 Thu, 10 Dec 2009 00:00:00 +0100 3072704 http://www.medworm.com/index.php?rid=3053769&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F147 Conclusions: hDM-C6MH3B1 constitutes a novel human based protein that addresses some of the limitations of ADEPT that currently preclude its successful use in the clinic. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3053769 Thu, 03 Dec 2009 00:00:00 +0100 3053769 http://www.medworm.com/index.php?rid=3045803&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F146 Conclusions: Our results indicate that B16 and F3II mouse tumor cell lines do not express NeuGc in cell membranes but they are able to incorporate NeuGc from an exogenous source, contributing to the malignant phenotype of melanoma and mammary carcinoma cells. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3045803 Tue, 01 Dec 2009 00:00:00 +0100 3045803 http://www.medworm.com/index.php?rid=3023945&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F145 Conclusion: EYA4 and hTERT mRNA expression increased with the severity of esophageal pathological changes and may be useful for identifying high-risk endoscopy candidates or for monitoring changes in premalignant esophageal lesions. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3023945 Wed, 25 Nov 2009 00:00:00 +0100 3023945 http://www.medworm.com/index.php?rid=3023946&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F144 Conclusion: The expressions of P-gp, LRP and MRP in patients with gastric cancer without prior chemotherapy are high, indicating that innate drug resistance may exist in gastric cancer. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=3023946 Tue, 24 Nov 2009 00:00:00 +0100 3023946 http://www.medworm.com/index.php?rid=2994270&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com Conclusions: VEGF expression should be considered in a routine diagnostic workup of children with neuroblastoma, especially in those more than 18 months old and with advanced disease stage. High VEGF expression at the time of disease diagnosis is a bad risk prognostic factor, and can be used to characterize subsets of patients with an unfavourable outcome. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2994270 Fri, 06 Nov 2009 00:00:00 +0100 2994270 http://www.medworm.com/index.php?rid=2968553&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F143 Conclusions: VEGF expression should be considered in a routine diagnostic workup of children with neuroblastoma, especially in those more than 18 months old and with advanced disease stage. High VEGF expression at the time of disease diagnosis is a bad risk prognostic factor, and can be used to characterize subsets of patients with an unfavourable outcome. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2968553 Fri, 06 Nov 2009 00:00:00 +0100 2968553 http://www.medworm.com/index.php?rid=2955998&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F142 Conclusion: Survival under octreotide treatment was not different compared to TACE or multimodal therapy and might be a therapeutic option for patients with HCC. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2955998 Tue, 03 Nov 2009 00:00:00 +0100 2955998 http://www.medworm.com/index.php?rid=2951717&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F141 Conclusions: Leukemic MSCs can inhibit K562 cell expansion and modulate the cell cycle to a state of relative quiescence. This allows the K562 cells to endure adverse conditions such as serum starvation. The PI3K-Akt-Bad signaling pathway may be involved in this antiapoptotic process via phosphorylation of the Akt and Bad proteins. Blocking MSC-induced transduction of the PI3K-Akt-Bad pathway may be a potential strategy for a targeted therapy to combat leukemia. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2951717 Tue, 03 Nov 2009 00:00:00 +0100 2951717 http://www.medworm.com/index.php?rid=2883865&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F139 Conclusions: The findings indicate that polymorphisms of G241R are rare in Chinese population and that KK genotype of ICAM-1 K469E is significantly associated with well differentiation of CRC. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2883865 Mon, 12 Oct 2009 23:00:00 +0100 2883865 http://www.medworm.com/index.php?rid=2883864&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F140 Conclusion Our results suggest that altered expression of integrins interacting with different extracellular matrixes may play a significant role in suppressing the aggressive invasive phenotype. Analysis of these clonal populations of MiaPaCa-2 provides a model for investigations into the invasive properties of pancreatic carcinoma. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2883864 Mon, 12 Oct 2009 23:00:00 +0100 2883864 http://www.medworm.com/index.php?rid=2877476&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F138 Conclusion: Perfusion CT seems to be a feasible and promising technique in monitoring the effects of cryoablation therapy. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2877476 Fri, 09 Oct 2009 23:00:00 +0100 2877476 http://www.medworm.com/index.php?rid=2877477&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F137 Retraction for Lee HJ, et al. Substance P and beta-endorphin mediate electro-acupuncture induced analgesia in mouse cancer pain model. J Exp Clin Cancer Res 2009, 28:102. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2877477 Thu, 08 Oct 2009 23:00:00 +0100 2877477 http://www.medworm.com/index.php?rid=2870121&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F135 Conclusions: Our study and the pooled results provide evidence for a differential role of the estrogen hydroxylation pathway in Pca development and encourage further study. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2870121 Wed, 07 Oct 2009 23:00:00 +0100 2870121 http://www.medworm.com/index.php?rid=2870120&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F136 Conclusions: 99mTc-HYNIC-annexin V in vivo imaging is a feasible method to detect early radiation-induced apoptosis in different tumors, and might be predictive for radiation sensitivity. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2870120 Wed, 07 Oct 2009 23:00:00 +0100 2870120 http://www.medworm.com/index.php?rid=2870122&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F134 Chromophobe renal cell carcinoma (ChRCC) is a subtype of renal cell carcinoma (RCC). ChRCC is diagnosed mainly in 6th decade of life. An incidence of ChRCC is similar in both men and woman. Eighty six percent of ChRCCs cases are diagnosed in stage 1 or 2. Prognosis of ChRCC is better than in other types of RCC. Five- and 10-year disease free survival (DFS) for ChRCC was 83.9% and 77.9%, respectively. Expression of immunohistological markers: cytokeratins (CK), vimentin, epithelial membrane antigen (EMA), CD10 could be potentially helpful in diagnosis of different subtypes of RCC. From all conventional RCC, CD 117 was detected (overexpression) in membrane of cells ChRCC.Overexpression of CD117 on cellular membranes of ChRCC could be a potential target for kinase inhibitors like: imatinib, d... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2870122 Tue, 06 Oct 2009 23:00:00 +0100 2870122 http://www.medworm.com/index.php?rid=2839868&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F132 Conclusions: Our findings suggest that endocrine therapy is an efficient therapy for inhibiting ERbeta-positive colon cancer cell proliferation and migration via down-regulation of MMP7. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2839868 Mon, 28 Sep 2009 23:00:00 +0100 2839868 http://www.medworm.com/index.php?rid=2839867&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F133 In this study, we prepared EGFRvIII-HBcAg fusion protein. After immunization with fusion protein, HBcAg or PBS, the titers of antibody in BALB/c mice immunized with fusion protein reached 2.75x105. Western blot analysis demonstrated that the fusion protein had specific antigenicity against anti-EGFRvIII antibody. Further observation showed fusion protein induced a high frequency of IFN-gamma-secreting lymphocytes. CD4+T cells rather than CD8+T cells were associated with the production of IFN-gamma. Using Renca-vIII(+) cell as specific stimulator, we observed remarkable cytotoxic activity in splenocytes from mice immunized with fusion protein. Mice were challenged with Renca-vIII(+) cells after five times immunization. In fusion protein group, three of ten mice failed to develop tumor and a... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2839867 Mon, 28 Sep 2009 23:00:00 +0100 2839867 http://www.medworm.com/index.php?rid=2825766&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F130 Conclusions: Our results indicate that PLK-1 production in HeLa cells might be critical in determining whether cells survive or undergo apoptosis. Therefore, targeting PLK-1 might be a promising strategy for enhancing sensitivity to chemotherapeutic reagents in cervical carcinoma. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2825766 Tue, 22 Sep 2009 23:00:00 +0100 2825766 http://www.medworm.com/index.php?rid=2825765&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F131 This study was designed to mainly evaluate the activity and safety of olanzapine compared with 5-hydroxytryptamine3(5-HT3)receptor antagonists for prevention of chemotherapy-induced nausea and vomiting(CINV) in patients receiving highly or moderately emetogenic chemotherapy(HEC or MEC). The second goal was to evaluate the impact of olanzapine on quality of life(QoL) of cancer patients during the period of chemotherapy. Methods: 229 patients receiving highly or moderately emetogenic chemotherapy were randomly assigned to the test group [ olanzapine(O) 10mg p.o. plus azasetron(A) 10mg i.v. and dexamethasone(D) 10mg i.v. on day 1; O 10mg once a day on days 2-5] or the control group(A 10mg i.v. and D 10mg i.v. on day 1; D 10 mg i.v. once a day on days 2-5). All the patients filled the observat... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2825765 Tue, 22 Sep 2009 23:00:00 +0100 2825765 http://www.medworm.com/index.php?rid=2815742&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F129 Conclusions: Our findings suggest the Sp1 transcription factor mediates ADAM17 expression under hypoxia, regulates glioma invasiveness, and thus, may be a target for anti-invasion therapies. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2815742 Mon, 21 Sep 2009 23:00:00 +0100 2815742 http://www.medworm.com/index.php?rid=2801921&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F128 Conclusions: Patients operated showed severe sexual dysfunction. The neurophysiological test may be a useful tool to investigate this complication. The neurological damage could be monitored to decide the rehabilitation strategy. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2801921 Wed, 16 Sep 2009 23:00:00 +0100 2801921 http://www.medworm.com/index.php?rid=2791035&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F127 Conclusions: The protease-free outgrowth of primary HBCEC offers a patient-specific approach to optimize an individually-designed cancer therapy. Moreover, HBCEC from long term breast tumor tissue cultures resemble tumor cell-like properties by an intact ECM formation and a stable cell surface protein expression providing a reproducible screening platform to identify new biomarkers and to test new therapeutics in individual tumor samples. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2791035 Sun, 13 Sep 2009 23:00:00 +0100 2791035 http://www.medworm.com/index.php?rid=2776073&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F125 Conclusions: IGF2 LOI is present in high frequency in Chinese gastric cancer patients, especially those with gastric corpus cancer. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2776073 Tue, 08 Sep 2009 23:00:00 +0100 2776073 http://www.medworm.com/index.php?rid=2776072&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F126 We present here the attempt of mining novel biomarkers for GC prognosis by using serum proteomics. Methods: Sera from 43 GC patients and 41 controls with gastritis as Group 1 and 11 GC patients as Group 2 was successively detected by Surface Enhanced Laser Desorption/ionization Time of Flight Mass Spectrometry (SELDI-TOF-MS) with Q10 chip. Peaks were acquired by Ciphergen ProteinChip Software 3.2.0 and analyzed by Zhejiang University-ProteinChip Data Analysis System (ZJU-PDAS). CEA level were evaluated by chemiluminescence immunoassay. Results: After median follow-up periods of 33 months, Group 1 with 4 GC patients lost was divided into 20 good-prognosis GC patients (overall survival more than 24 months) and 19 poor-prognosis GC patients (no more than 24 months). The established prognosis ... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2776072 Tue, 08 Sep 2009 23:00:00 +0100 2776072 http://www.medworm.com/index.php?rid=2770812&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F124 Conclusions: Genistein inhibits VM formation of uveal melanoma cells in vivo and in vitro. One possible underlying molecular mechanism by which Genistein could inhibit VM formation of uveal melanoma is related to down-regulation of VE-cadherin. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2770812 Sun, 06 Sep 2009 23:00:00 +0100 2770812 http://www.medworm.com/index.php?rid=2753739&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F123 Conclusions: These results suggested that PTEN gene is an important regulator on TKI inhibition, and the resistance to tyrosine kinase inhibitors might be reversed by irradiation in PTEN low expression cancer cells. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2753739 Mon, 31 Aug 2009 23:00:00 +0100 2753739 http://www.medworm.com/index.php?rid=2742406&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F121 Background: In cancer patients, MUC1 glycoprotein may carry Lewis y which could be involved in immune response. Purposes: 1- to evaluate the presence of Lewis y and MUC1 in circulating immune complexes (Lewis y/CIC and MUC1/CIC, respectively) and their correlation; 2- to analyze the possible presence of Lewis y in carbohydrate chains of tumoral MUC1 glycoprotein and 3- to correlate serum and tissue parameters considered. Methods: Pretreatment serum and tissue breast samples from 76 adenocarcinoma, 34 benign and 36 normal specimens were analyzed. Anti-MUC1 and Anti-Lewis y MAbs were employed. To detect Lewis y/CIC and MUC1/CIC, ELISA tests were developed; serum samples containing MUC1 were previously selected by Cancer Associated Serum Antigen (CASA). Immunoprecipitation (IP) was performed ... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2742406 Thu, 27 Aug 2009 23:00:00 +0100 2742406 http://www.medworm.com/index.php?rid=2742405&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F122 Conclusion: These findings elucidate that there are common features between CHB-developed HCC and LC-developed HCC. The identified proteins are valuable for studying the hepatocarcinogenesis, and may be potential diagnostic markers or therapeutic targets for HBV-related HCC. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2742405 Thu, 27 Aug 2009 23:00:00 +0100 2742405 http://www.medworm.com/index.php?rid=2735409&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F120 Background: Germ cell testicular tumors have a survival rate that diminishes with high tumor marker levels, such as human chorionic gonadotropin (hCG). hCG may regulate vascular neoformation through vascular endothelial growth factor (VEGF). Our purpose was to determine the relationship between hCG serum levels, angiogenesis, and VEGF expression in germ cell testicular tumors. Methods: We conducted a retrospective study of 101 patients. Serum levels of hCG, alpha-fetoprotein (AFP), and lactate dehydrogenase were measured prior to surgery. Vascular density (VD) and VEGF tissue expression were determined by immunohistochemistry and underwent double-blind analysis. Results: Histologically, 46% were seminomas and 54%, non-seminomas. Median follow-up was 43 +/- 27 months. Relapse was present in... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2735409 Wed, 26 Aug 2009 23:00:00 +0100 2735409 http://www.medworm.com/index.php?rid=2735410&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F119 This study was designed to explore the feasibility, safety, and outcomes of pre-operative oxaliplatin-dacarbazine combination therapy for the treatment of advanced soft tissue sarcoma (STS) of the limb.Patients and Methods: Between November 2005 and November 2008, 31 patients with advanced limb STS classified with stage IV STS were randomly assigned into experimental or control groups, and both were given 2 cycles of chemotherapy before undergoing surgery. The regimen for the experimental group was oxaliplatin (120 mg/m2, d1) in combination with dacarbazine (175 mg/m2, d1-3), while that for the control group was a standard vincristine, epirubicin, cyclophosphamide therapy. Operations were carried out four weeks after the second chemotherapy cycle, followed by another 2-4 more chemotherapy ... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2735410 Tue, 25 Aug 2009 23:00:00 +0100 2735410 http://www.medworm.com/index.php?rid=2717333&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F118 Background: Vimentin is one of the cytoplasmic intermediate filament proteins which are the major component of the cytoskeleton. In our study we checked the usefulness of vimentin expression in identifying cases of breast cancer with poorer prognosis, by adding vimentin to the immunopanel consisting of basal type cytokeratins, estrogen, progesterone, and HER2 receptors. Methods: 179 tissue specimens of invasive operable ductal breast cancer were assessed by the use of immunohistochemistry. The median follow-up period for censored cases was 90 months. Results: 38 cases (21.2%) were identified as being vimentin-positive. Vimentin-positive tumours affected younger women (p=0.024), usually lacked estrogen and progesterone receptor (p (Source: Journal of Experimental and Clinical Cancer Researc... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2717333 Wed, 19 Aug 2009 23:00:00 +0100 2717333 http://www.medworm.com/index.php?rid=2738866&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F117 Conclusion: The ≥ G2 late toxicities in both arms were comparable, indicating the feasibility of hypofractionated regimes in prostate cancer. An α/β ratio for late rectal toxicity very close to 3 Gy was found. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2738866 Tue, 18 Aug 2009 23:00:00 +0100 2738866 http://www.medworm.com/index.php?rid=2710182&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F116 Conclusions: Our data suggest that in DLBL patients, mortality was affected by RDI of R-CHOP as the initial treatment, and the retention of a high RDI could therefore be crucial. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2710182 Tue, 18 Aug 2009 23:00:00 +0100 2710182 http://www.medworm.com/index.php?rid=2710181&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F117 Conclusions: The >= G2 late toxicities in both arms were comparable, indicating the feasibility of hypofractionated regimes in prostate cancer. An alfa beta ratio for late rectal toxicity very close to 3 Gy was found. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2710181 Tue, 18 Aug 2009 23:00:00 +0100 2710181 http://www.medworm.com/index.php?rid=2748638&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F113 Compounds derived from biologic sources, or biologicals, are increasingly utilized as therapeutic agents in malignancy. Development of anti-cancer targeted therapies from biologics is increasingly being utilized. Cetuximab, a chimeric monoclonal antibody, is one such anti-cancer targeted therapeutic that has shown efficacy in quelling the rate of patient decline in colorectal, head/neck, and non-small cell lung cancer. However, due to the relatively recent addition of biologic compounds to the therapeutic arsenal, information related to adverse reactions is less well known than those seen in traditional chemotherapeutics. Dermatologic reactions have been demonstrated as the most frequent side effect cited during cetuximab therapy for malignancy; however, other effects may lead to greater m... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2748638 Thu, 13 Aug 2009 23:00:00 +0100 2748638 http://www.medworm.com/index.php?rid=2700716&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F113 Compounds derived from biologic sources, or biologicals, are increasingly utilized as therapeutic agents in malignancy. Cetuximab, a chimeric monoclonal antibody, is one such biologic that has shown efficacy in quelling the rate of patient decline in colorectal, head/neck, and non-small cell lung cancer. However, due to the relatively recent addition of these biologic compounds to the therapeutic arsenal, information related to adverse reactions are less well known than those seen in traditional chemotherapeutics. Dermatologic reactions have been demonstrated as the most frequent side effect cited during cetuximab therapy for malignancy; however, other effects may lead to greater morbidity. In general, pulmonary complications of therapeutics can lead to significant morbidity and mortality... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2700716 Thu, 13 Aug 2009 23:00:00 +0100 2700716 http://www.medworm.com/index.php?rid=2700715&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F114 The treatment of soft tissue tumors needs the coordinated adoption of surgery with radiation therapy and eventually, chemotherapy. The radiation therapy (delivered with a linear accelerator) can be preoperative, intraoperative, or postoperative. In selected patients adjuvant brachytherapy can be adopted. The goal of these associations is to achieve tumor control while maximally preserving the normal tissues from side effects. Unfortunately, the occurrence of local and distant complications is still elevated. Electrochemotherapy is a novel technique that combines the administration of anticancer agents to the application of permeabilizing pulses in order to increase the uptake of antitumor molecules. While its use in humans is still confined to the treatment of cutaneous neoplasms or the pa... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2700715 Thu, 13 Aug 2009 23:00:00 +0100 2700715 http://www.medworm.com/index.php?rid=2700714&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F115 Conclusion: Collectively, the results of the present study suggest that TP53 codon 72 polymorphisms might not be a low-penetrant risk factor for developing breast carcinoma. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2700714 Thu, 13 Aug 2009 23:00:00 +0100 2700714 http://www.medworm.com/index.php?rid=2692948&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F112 We examined survival rates and pooled 15 studies reporting on 6 month outcomes (RR 1.10, 95% CI, 1.04-1.15, P= (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2692948 Tue, 11 Aug 2009 23:00:00 +0100 2692948 http://www.medworm.com/index.php?rid=2682900&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F111 Conclusions: These results revealed a cytoplastic expression pattern of APMCF1 and up-regulated in tumour tissues suggesting APMCF1 may have potential relationship with oncogenesis. The data presented should serve as a useful reference for further studies of APMCF1 functions in tumorigenesis and might provide a potential anti-tumor target. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2682900 Sat, 08 Aug 2009 23:00:00 +0100 2682900 http://www.medworm.com/index.php?rid=2682901&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F110 Conclusions As2O3 exerted synergistic effects with DDP on NSCLC cells, and the synergistic effects were partly due to the induction of caspase-independent apoptosis. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2682901 Fri, 07 Aug 2009 23:00:00 +0100 2682901 http://www.medworm.com/index.php?rid=2679714&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F109 Conclusion: mFOLFOX6 therapy was well-tolerated and effective in both non-elderly and elderly patients. However, discontinuation of treatment was sometimes necessary due to peripheral neuropathy, which is dose-limiting toxicity of this therapy. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2679714 Thu, 06 Aug 2009 23:00:00 +0100 2679714 http://www.medworm.com/index.php?rid=2675751&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F108 Conclusions: De novo expression of Cdx2 is an early event in the spectrum of the lesions induced by experimental gastro-esophageal reflux and should be considered as a key step in the morphogenesis of esophageal adenocarcinoma. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2675751 Thu, 06 Aug 2009 23:00:00 +0100 2675751 http://www.medworm.com/index.php?rid=2646682&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F107 Conclusions: In this study, we provide the global gene expression profiles during the development and progression of liver cancer in rats. The data obtained from the gene expression profiles will allow us to acquire insights into the molecular mechanisms of hepatocarcinogenesis and identify specific genes (or gene products) that can be used for early molecular diagnosis, risk analysis, prognosis prediction, and development of new therapies. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2646682 Tue, 28 Jul 2009 23:00:00 +0100 2646682 http://www.medworm.com/index.php?rid=2635546&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F106 Conclusions: Though the frequency of SNP was tended to be higher in NSCLC patients than healthy volunteers (57.7%), as the difference was not significant, we have concluded that there is no relation between Rad18 SNP and lung cancer development. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2635546 Fri, 24 Jul 2009 23:00:00 +0100 2635546 http://www.medworm.com/index.php?rid=2627732&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F105 Conclusions: Given that MMP-2 and MMP-9 are instrumental in tumor cell invasion, our results suggest the risedronate could reduce osteosarcoma cell invasion. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2627732 Tue, 21 Jul 2009 23:00:00 +0100 2627732 http://www.medworm.com/index.php?rid=2614710&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F104 Conclusions: The results of this case-control study indicate that the polymorphism rs13181 might be a risk factor for predisposition towards SCCHN and Breast cancer among north Indian subpopulations. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2614710 Fri, 17 Jul 2009 23:00:00 +0100 2614710 http://www.medworm.com/index.php?rid=2612141&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F103 Conclusions: The method that incorporates prior knowledge into discriminant analysis could effectively improve the capacity and reduce the impact of noise. This idea may have good future not only in practice but also in methodology. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2612141 Fri, 17 Jul 2009 23:00:00 +0100 2612141 http://www.medworm.com/index.php?rid=2607256&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F101 Retraction (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2607256 Wed, 15 Jul 2009 23:00:00 +0100 2607256 http://www.medworm.com/index.php?rid=2607255&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F102 Conclusions: The findings of this study suggest that a S-180 cancer pain model is useful as a consistent and short time animal model. It also indicated that EA treatment could be used as an alternative therapeutic method for cancer pain due to a consequent decrease in substance P and increase in beta-endorphin levels. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2607255 Wed, 15 Jul 2009 23:00:00 +0100 2607255 http://www.medworm.com/index.php?rid=2599324&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F100 Conclusions: Taken together, our data demonstrated that calcimimetic R-568 triggers an intrinsic mitochondria-related apoptotic pathway, which is modulated by Bcl-xL protein. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2599324 Mon, 13 Jul 2009 23:00:00 +0100 2599324 http://www.medworm.com/index.php?rid=2589406&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F99 Conclusions: This study suggests that intentional inhibition of ABCB1 and ABCG2 function at the blood-brain barrier is unlikely to significantly improve clinical outcome of imatinib with currently used dosing regimens. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2589406 Thu, 09 Jul 2009 23:00:00 +0100 2589406 http://www.medworm.com/index.php?rid=2581788&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F98 Conclusion: VEGF-C/D and Flt-4 may play an important role in the process of lymphatic metastasis of early-stage invasive cervical carcinoma through paracrine and autocrine mechanisms. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2581788 Wed, 08 Jul 2009 23:00:00 +0100 2581788 http://www.medworm.com/index.php?rid=2564099&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F97 Conclusion: Non-small cell lung cancer patients with high expression of HER2 exhibited resistance to cisplatin-based chemotherapies that are the standard treatment for this disease. Our results indicate that HER2 status may be a predictive and prognostic factor for cisplatin- based therapy response and disease survival. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2564099 Thu, 02 Jul 2009 23:00:00 +0100 2564099 http://www.medworm.com/index.php?rid=2557399&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F95 Conclusions: The CT-plan is superior to the conventional plan in target volume coverage and appropriate evaluation of OARs, as the conventional plan overestimates tumor doses and underestimates OAR doses. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2557399 Tue, 30 Jun 2009 23:00:00 +0100 2557399 http://www.medworm.com/index.php?rid=2557398&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F96 Conclusions: Resveratrol is cytotoxic and inhibits, in a dose dependent fashion, the synthesis of polyomavirus DNA in the infected cell. Furthermore, this inhibition is observed at non cytotoxic concentrations of the drug. Our data imply that cyto-toxicity may be attributed to the membrane damage caused by the drug and that the transfer of polyomavirus from the endoplasmic reticulum to the cytoplasm may be hindered. In conclusion, the cytotoxic and antiviral properties of resveratrol make it a potential candidate for the clinical control of proliferative as well as viral pathologies. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2557398 Tue, 30 Jun 2009 23:00:00 +0100 2557398 http://www.medworm.com/index.php?rid=2553875&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F93 Conclusions: Prx I and Trx1 are overexpressed in human breast carcinoma and the expression levels are associated with tumor grade. The striking induction of Prx I and Trx1 in breast cancer may enable their use as breast cancer markers. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2553875 Mon, 29 Jun 2009 23:00:00 +0100 2553875 http://www.medworm.com/index.php?rid=2550752&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F91 Conclusion: SNP of XRCC1 gene at codon 399 influences the response of cervical carcinoma to platinum-based NAC. This is probably due to changes in expression of XRCC1 protein, affecting response to chemotherapy. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2550752 Sun, 28 Jun 2009 23:00:00 +0100 2550752 http://www.medworm.com/index.php?rid=2524193&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F90 Conclusions: From our study, we may conclude that CHOP 5'UTR-c.279T>C and +nt30C>T genotypes and corresponding haplotypes are not associated with pre-obesity and tumors/cancer. However, more studies are warranted to establish the role of CHOP variants in overweight condition and in tumor/cancer predisposition. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2524193 Thu, 25 Jun 2009 23:00:00 +0100 2524193 http://www.medworm.com/index.php?rid=2486232&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F89 Background: Lung cancer is the leading cause of death from cancer worldwide. Conventional studies mainly think that insulin-like growth factor-I ( IGF-I ) and IGF-binding protein-3(IGFBP-3) may promote and inhibit tumor growth, respectively. However, there are many different results about their function in some recent epidemiological studies. To evaluate the relationship between circulating serum levels of IGF-I, IGFBP-3 and lung cancer, a systematic review and meta-analysis of the published data was performed. Methods: Literatures searched on PubMed and Embase databases were enrolled in the Meta-analysis. The Meta-analysis of all eligible studies was applied with Stata 10.0 software, and the pooled odds ratio (OR) and weighted mean difference(WMD) value were obtained. The Q test, Egger's ... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2486232 Tue, 23 Jun 2009 23:00:00 +0100 2486232 http://www.medworm.com/index.php?rid=2486233&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F88 Conclusion: There were no deaths related to 125I seed implant. In this preliminary investigation, 125I seed implant provided excellent palliation of pain relief, local control and prolong the survival of patients with stage II and III disease to some extent. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2486233 Mon, 22 Jun 2009 23:00:00 +0100 2486233 http://www.medworm.com/index.php?rid=2486234&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F87 Conclusions: Texture characteristics of MRI data were classified successfully; this proved texture analysis to be potential quantitative means of representing lymphoma tissue changes during chemotherapy response monitoring. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2486234 Sun, 21 Jun 2009 23:00:00 +0100 2486234 http://www.medworm.com/index.php?rid=2486235&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F86 Objectives: We aimed to determine the incidence of women's breast cancer in Italy without using statistical approximations. Methods: We analyzed the national hospitalizations database at the Ministry of Health to calculate the number of major surgeries (mastectomies and quadrantectomies) in Italian women due to breast cancer between 2000 and 2005, overall and by age groups ( (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2486235 Thu, 18 Jun 2009 23:00:00 +0100 2486235 http://www.medworm.com/index.php?rid=2486237&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F84 In this study, we evaluated the cytotoxic properties of the pH neutral salt zinc acetate on the prostate cancer cell lines PC3, DU145 and LNCaP. Zinc acetate killed prostate cancer cell lines in vitro, independent of androgen sensitivity, in a dose-dependent manner in a range between 200 and 600 uM. Cell death occurred rapidly with 50% cell death by six hours and maximal cell death by 18 hours. We next established a xenograft model of prostate cancer and tested an experimental treatment protocol of direct intra-tumoral injection of zinc acetate. We found that zinc treatments halted the growth of the prostate cancer tumors and substantially extended the survival of the animals, whilst causing no detectable cytoxicity to other tissues. Thus, our studies form a solid proof-of-concept that dir... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2486237 Tue, 16 Jun 2009 23:00:00 +0100 2486237 http://www.medworm.com/index.php?rid=2486236&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F85 Conclusion: This high-flux proteomic classification system will provide a highly accurate and innovative approach for the detection/diagnosis of NPC. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2486236 Tue, 16 Jun 2009 23:00:00 +0100 2486236 http://www.medworm.com/index.php?rid=2479001&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F82 Conclusions: Our data show miR-9 and miR-433 was down-regulated in gastric carcinoma. The targets of miR-433 and miR-9 were tumor-associated proteins GRB2 and RAB34 respectively. This result provided the related information of miRNAs in gastric carcinoma. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2479001 Tue, 16 Jun 2009 04:00:00 +0100 2479001 http://www.medworm.com/index.php?rid=2479000&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F83 Conclusions: dCK mRNA expression is a candidate indicator for GEM efficacy in unresectable pancreatic cancer. Quantitative mRNA measurements of dCK using EUS-FNA samples are necessary for definitive conclusions. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2479000 Tue, 16 Jun 2009 04:00:00 +0100 2479000 http://www.medworm.com/index.php?rid=2479002&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F81 In this study, we constructed an oncolytic adenovirus with a Survivin targeted small hairpin RNA and a reporter gene (ZD55-Sur-EGFP). The expression of Survivin mRNA and protein were analyzed by RT-PCR and western blot. The cell growth and apoptosis were tested by in vitro cytopathic assay, MTT assay and flow cytometry respectively. The effect of the constructed virus on xenograft model was evaluated by tumor volume and western blot analysis. Results: ZD55-Sur-EGFP replicated in cancer cells specifically, reduced the expression of Survivin mRNA and protein expression effectively (P (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2479002 Mon, 15 Jun 2009 04:00:00 +0100 2479002 http://www.medworm.com/index.php?rid=2475087&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F79 Conclusions: VAE shows some positive effects in breast and gynaecological cancer. More research into clinical efficacy is warranted. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2475087 Thu, 11 Jun 2009 04:00:00 +0100 2475087 http://www.medworm.com/index.php?rid=2475086&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F80 Conclusion: This paper demonstrated that preventive effect of quercetin on hepatocarcinoma in rats by RAPD-PCR, tracing the effect on p53 gene and by histopathological evidence. Hereby, it was proved that quercetin exerted its preventive effect via decreased oxidative stress and decreased antioxidant activity. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2475086 Thu, 11 Jun 2009 04:00:00 +0100 2475086 http://www.medworm.com/index.php?rid=2470196&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F78 Background: FBG2 (F-BOX6) gene is an important member in ubiquitin metabolic system F-BOX family, and forms E3 complex with the other members in the family. But its role in gastric cancer is still not clear. In the present study, we intended to investigate the influence of FBG2 on the growth, proliferation, apoptosis ,invasion and cell cycle of the gastric cancer line MKN45 and gastric cell line HFE145. Methods: As a critical component of ubiquitin-protein ligase complexFBG2 cDNA was subcloned into a constitutive vector PCDNA3.1 followed by transfection in MKN45 and HFE145 by using liposome. Then stable transfectants were selected and appraised. The apoptosis and cell cycles of these clones were analyzed by using flow cytometry. The growth and proliferation were analyzed by cell growth cur... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2470196 Wed, 10 Jun 2009 04:00:00 +0100 2470196 http://www.medworm.com/index.php?rid=2459050&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F76 Background: We observed that paclitaxel altered the pharmacokinetic properties of gemcitabine in patients with non-small cell lung cancer (NSCLC) and limited the accumulation of gemcitabine and its metabolites in various primary and immortalized human cells. Therefore, we classified the drug-drug interaction and the effects of paclitaxel on deoxycytidine kinase (dCK) and cytidine deaminase (CDA) in three NSCLC cell lines. These enzymes are responsible for the metabolism of gemcitabine to its deaminated metabolite dFdU (80% of the parent drug) and the phosphorylated metabolites dFdCMP, dFdCDP and dFdCTP. These metabolites appear to relate to sensitivity and tolerability of gemcitabine based on previous animal and laboratory studies. Methods: Three immortalized human cells representative of... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2459050 Sat, 06 Jun 2009 04:00:00 +0100 2459050 http://www.medworm.com/index.php?rid=2459052&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F74 Conclusions: These findings suggested that CENP-H involves in the development and progression of tongue cancer. CENP-H might be a valuable prognostic indicator for tongue cancer patients within early stage. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2459052 Fri, 05 Jun 2009 04:00:00 +0100 2459052 http://www.medworm.com/index.php?rid=2459051&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F75 Conclusions: Our data indicate that Ad-PEDF may provide an effective approach to inhibit mouse B16-F10 melanoma growth. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2459051 Fri, 05 Jun 2009 04:00:00 +0100 2459051 http://www.medworm.com/index.php?rid=2459053&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F73 Conclusion: HGF regulates Rac-1-induced ROS production through the Akt pathway and ROS regulates uPA production and invasion via MAP kinase, which provides novel insight into the mechanisms underlying the progression of gastric cancer. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2459053 Thu, 04 Jun 2009 04:00:00 +0100 2459053 http://www.medworm.com/index.php?rid=2448552&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F72 Background: The relapse of cancer after radiotherapy is a clinical knotty problem. Previous studies have demonstrated that the elevation of several factors is likely in some way to lead to the development of treatment tolerance, so it is necessary to further explore the problem of re-proliferated radioresistant cells to chemotherapeutic agents. In the present study, we aimed to investigate the chemosensitivity of radioresistant cells originated from the multicellular spheroids of A549 lung adenocarcinoma. Methods: After irradiated with 25 Gy of 6 MV X-ray to A549 multicellular spheroids, whose 10th re-proliferated generations were employed as radioresistant cells, and the control groups were A549 parental cells and MCF7/VCR resistant cells. The chemo-sensitivity test was made by six kinds ... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2448552 Tue, 02 Jun 2009 04:00:00 +0100 2448552 http://www.medworm.com/index.php?rid=2443194&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F71 Conclusions: PDCD4 expression is inversely correlated to the metastatic potential of HCC cells. PDCD4 can effectively suppress the metastatic potential of HCC cells. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2443194 Fri, 29 May 2009 04:00:00 +0100 2443194 http://www.medworm.com/index.php?rid=2443195&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F70 Background: Insulin-like growth factor binding proteinIGFBPs have been as potential tumor suppressors in the occurrence and development of tumors. Cellular Fas-associated death domain-like interleukin-1beta-converting enzyme (FLICE)-like inhibitory protein (cFLIP) contains a death effect domain (DED), which blocks death receptor pathway and inhibits apoptosis.Materials and Methods: We collected normal cervical tissues from 28 subjects, CIN samples from 37 patients, and cervical cancer tissues from 40 patients. In these samples, we then measured the expression levels of IGFBP-5 and cFLIP via RT-PCR and immunohistochemistry, and we detected the presence of high-risk HPV by Hybrid capture II assays in cervical secretions provided by the subjects. Results: significant differences in the expres... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2443195 Thu, 28 May 2009 04:00:00 +0100 2443195 http://www.medworm.com/index.php?rid=2437231&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F69 This article reviews what has to be rather what has been done in the field for the development of future vaccines in HN tumours. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2437231 Wed, 27 May 2009 04:00:00 +0100 2437231 http://www.medworm.com/index.php?rid=2437232&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F67 Conclusion: Crosslinking alpha6beta4 integrin in breast carcinoma cells induces EGFR clustering and preferentially promotes Rho activation in response to EGF. We hypothesize that this integrin-EGFR crosstalk may facilitate tumor cell cytoskeletal rearrangements important for tumor progression. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2437232 Tue, 26 May 2009 04:00:00 +0100 2437232 http://www.medworm.com/index.php?rid=2428739&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F66 Molecularly targeted agents for the treatment of solid tumors had entered the market in the last 5 years, with a great impact upon both the scientific community and the society. Many randomized phase III trials conducted in recent years with new targeted agents, despite previous data coming from preclinical research and from phase II trials were often promising, have produced disappointingly negative results. Some other trials have actually met their primary endpoint, demonstrating a statistically significant result favouring the experimental treatment. Unfortunately, with a few relevant exceptions, this advantage is often small, if not negligible, in absolute terms. The difference between statistical significance and clinical relevance should always be considered when translating clinical... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2428739 Fri, 22 May 2009 04:00:00 +0100 2428739 http://www.medworm.com/index.php?rid=2417580&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F65 In this study, we examined phospho-ERK1/2 (p-ERK1/2) and PI3K expression and analyzed its clinicopathological impact in gallbladder adenocarcinoma. Methods: Immunohistochemistry was used to detect and compare the frequency of p-ERK1/2 and PI3-K expression in gallbladder adenocarcinoma, peri-tumor tissues, adenomatous polyps, and chronic cholecystitis specimens. Results: The positive staining for p-EKR1/2 and PI3-K were 63/108 (58.3%) and 55/108 (50.9%) in gallbladder adenocarcinoma; 14/46 (30.4%) and 5/46 (10.1%) in peri-tumor tissues; 3/15 (20%) and 3/15 (20%) in adenomatous polyps; and 4/35 (11.4%) and 3/35 (8.6%) in chronic cholecystitis. The positive rate of p-ERK1/2 or PI3-K in gallbladder adenocarcinoma was significantly higher than that in peri-tumor tissue (both, P (Source: Journ... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2417580 Mon, 18 May 2009 04:00:00 +0100 2417580 http://www.medworm.com/index.php?rid=2406672&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F64 Conclusions: Our findings identified specific microRNA expression in oral squamous cell carcinoma and suggested that microRNAs have a role in oral carcinogenesis. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2406672 Wed, 13 May 2009 04:00:00 +0100 2406672 http://www.medworm.com/index.php?rid=2406674&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F62 Conclusions: This study defined regions of the genome associated with changes in DNA copy number and gene expression in specific subtypes of biliary cancers. The findings have implications for identification of therapeutic targets, screening, and prognostication. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2406674 Tue, 12 May 2009 04:00:00 +0100 2406674 http://www.medworm.com/index.php?rid=2406673&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F63 In this study, HA117 gene was investigated whether it could increase the drug resistance in chronic myelogenous myeloid leukemia cell line K562. Methods: HA117 was cloned and adenovirus vectors were constructed with the HA117 gene (Adeasy-HA117). K562 cells were infected by Ad-HA117 to get the K562/Ad-HA117 cells with HA117 gene expression. The infection efficiency and the multiplicity of infection (MOI) were detected by fluorescence and flow cytometry. The expression of HA117 gene was detected by RT-PCR. The drug sensitivities of K562/Ad-HA117 cells were detected by Methyl Thiazolyl Tetrazolium (MTT) assay. Results: Recombinant adenovirus vectors were constructed and a MOI of 100 is most suitable to infect K562 cells. The infected K562 cells demonstrated in vitro production of HA117 mRN... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2406673 Tue, 12 May 2009 04:00:00 +0100 2406673 http://www.medworm.com/index.php?rid=2390988&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F61 Conclusions: Opioid switching at 50% of the calculated equianalgesic dose produced a significant reduction in pain levels and rescue medication. The incidence of side effects decreased and no new side effects were noted. Further studies are required to provide individualized treatment for patients according to their different types of cancer. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2390988 Thu, 07 May 2009 04:00:00 +0100 2390988 http://www.medworm.com/index.php?rid=2390989&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F60 CONCLUSION: This study highlights the importance of taking into consideration not only seizure control but also the appearance of side effects when choosing antiepileptic drugs in this patients population. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2390989 Wed, 06 May 2009 04:00:00 +0100 2390989 http://www.medworm.com/index.php?rid=2377307&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F58 Conclusions: Data indicate that deregulation of the Wnt pathway by HBsAg occurred in HBV-associated HCCs, but was more pronounced in the peritumor cells. It is speculated that HBsAg could stimulate proliferation and functional modification of hepatocytes via LEF-1 through the Wnt pathway at the pre-malignant stage. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2377307 Wed, 29 Apr 2009 04:00:00 +0100 2377307 http://www.medworm.com/index.php?rid=2370332&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F56 BZ participated in designing the study, western blot analysis, real-time qPCR and data analysis of microarray. XW participated in the design of the study and conducted cell line transformation and cell experiments. YW conceived of the study, participated in its design and coordination, and drafted the manuscript. All authors read and approved the final manuscript. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2370332 Tue, 28 Apr 2009 04:00:00 +0100 2370332 http://www.medworm.com/index.php?rid=2370331&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F57 Conclusions: Our research convinces that the detection of CK19 in peripheral blood by flow cytometry is also a specific and feasible method to monitor circulating tumor cells in breast cancer. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2370331 Tue, 28 Apr 2009 04:00:00 +0100 2370331 http://www.medworm.com/index.php?rid=2370333&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F55 Background: To investigate influencing factors of the metastatic lymph nodes ratio (MLR) and whether it is related to survival in patients with gastric adenocarcinoma. Methods: We retrospectively evaluated the clinical features of 121 patients with gastric adenocarcinoma enrolled in our hospital between 2000 and 2007. The receiver operating characteristic (ROC) curve was used to determine the cutoff of the MLR, and CK20 immunohistochemical staining was used to detect micrometastasis of the lymph nodes. Results: The areas under the ROC curve of MLR used to predict the death of 3-year and 5-year postoperative patients were 0.826 +/- 0.053 and 0.896 +/- 0.046. Thus MLR = 30.95% and MLR = 3.15% were designated as cutoffs. The MLR was then classified into three groups: MLR1 (MLR30.95%). We foun... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2370333 Sun, 26 Apr 2009 04:00:00 +0100 2370333 http://www.medworm.com/index.php?rid=2365895&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F54 Correction to Kleiner HE, Krishnan P, Tubbs J, Smith M, Meschonat C, Shi R, Lowery-Nordberg M, Adegboyega P, Unger M, Cardelli J et al: Tissue microarray analysis of eIF4E and its downstream effector proteins in human breast cancer. J Exp Clin Cancer Res 2009, 28:5. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2365895 Fri, 24 Apr 2009 04:00:00 +0100 2365895 http://www.medworm.com/index.php?rid=2356755&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F53 Conclusions: SPEF with high frequency could also achieve similar antitumor efficiency which can be used to reduce unpleasant sensations in tumor electrical treatment. Our research proposed potential applications of using high frequency SPEF in clinical cancer treatment. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2356755 Wed, 22 Apr 2009 04:00:00 +0100 2356755 http://www.medworm.com/index.php?rid=2342641&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F52 In this study, for the first time we constructed recombinant adenovirus to investigate the inhibitory effects of RhoA and RhoC shRNAs in tandem expression on the cell proliferation and invasion of colorectal cancer HCT116 cells. Methods: The recombinant adenovirus carrying RhoA and RhoC shRNAs in tandem expression was transfected into HCT116. The mRNA transcription and protein expressions of RhoA and RhoC were examined by RT-FQPCR and Western blot respectively. Cellular proliferation inhibitory activity was determined by methyl thiazolyl tetrazolium (MTT) assay and invasive and migrating potential was detected through in vitro Matrigel coated invasion and migration assay. Results: Both mRNA and proteins Levels of RhoA and RhoC were significantly reduced in HCT116 cells transfected with Ad-... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2342641 Sat, 18 Apr 2009 04:00:00 +0100 2342641 http://www.medworm.com/index.php?rid=2331387&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F51 CONCLUSION: Cancer-related frequencies appear to be tumor-specific and treatment with tumor-specific frequencies is feasible, well tolerated and may have biological efficacy in patients with advanced cancer. Trial registration: clinicaltrials.gov identifier NCT00805337 (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2331387 Tue, 14 Apr 2009 04:00:00 +0100 2331387 http://www.medworm.com/index.php?rid=2331389&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F49 Conclusions: We propose that a cause of endometriosis is the dislocation of primitive endometrial tissue outside the uterine cavity during organogenesis. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2331389 Thu, 09 Apr 2009 04:00:00 +0100 2331389 http://www.medworm.com/index.php?rid=2331388&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F50 Conclusion: The obtained results are the consequence of a high resistance of HTB140 melanoma cells to protons and/or drugs. The inactivation level of the HTB140 human melanoma cells after protons, FM or DTIC treatments was not enhanced by their combined application. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2331388 Thu, 09 Apr 2009 04:00:00 +0100 2331388 http://www.medworm.com/index.php?rid=2331390&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F48 Background: Uveal melanoma (UM) cell lines, when exposed to blue light in vitro, show a significant increase in proliferation. In order to determine if similar effects could be seen in vivo, we investigated the effect of blue light exposure in a xenograft animal model of UM. Methods: Twenty New Zealand albino rabbits were injected with 1.0x10^6 human UM cells (92.1) in the suprachoroidal space of the right eye. Animals were equally divided into two groups; the experimental group was exposed to blue light, while the control group was protected from blue light exposure. The eyes were enucleated after sacrifice and the proliferation rates of the re-cultured tumor cells were assessed using a Sulforhodamine-B assay. Cells were re-cultured for 1 passage only in order to maintain any in vivo cell... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2331390 Tue, 07 Apr 2009 04:00:00 +0100 2331390 http://www.medworm.com/index.php?rid=2303845&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F47 Conclusion: Our meta-analysis shows that there are no differences between HDR and LDR for overall survival, local recurrence and late complications for clinical stages I, II and III. By means of the GRADE system, we recommend the use of HDR for all clinical stages of cervix cancer. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2303845 Sun, 05 Apr 2009 04:00:00 +0100 2303845 http://www.medworm.com/index.php?rid=2303847&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F45 Conclusions: Scapular allograft reconstruction had a satisfactory functional, cosmetic, and oncological outcome in this case series. Preservation and reconstruction of the articular capsule and deltoid are proposed to be a prerequisite for using scapular allografts and rotator cuff reconstruction is recommended, although technically challenging to perform. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2303847 Wed, 01 Apr 2009 04:00:00 +0100 2303847 http://www.medworm.com/index.php?rid=2303846&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F46 Conclusion: The data were proved to be stable via sensitivity analyses. The results suggest GSTM1 deletion as a risk factor for NPC and failed to suggest a marked correlation of GSTT1 polymorphisms with NPC risk. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2303846 Wed, 01 Apr 2009 04:00:00 +0100 2303846 http://www.medworm.com/index.php?rid=2303848&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F44 Conclusions: The current study indicates that a vulnerability of the cytoskeleton components, such as the contractile ring, causes multinucleation to occur from the telophase to the cytokinesis of the cell cycle. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2303848 Tue, 31 Mar 2009 04:00:00 +0100 2303848 http://www.medworm.com/index.php?rid=2303849&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F43 Conclusions: These results indicate that TKTL1 plays an important role in total transketolase activity and cells proliferation in uterine cervix cancer. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2303849 Mon, 30 Mar 2009 04:00:00 +0100 2303849 http://www.medworm.com/index.php?rid=2303850&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F42 Background: Cell cycle checkpoint regulation is crucial for prevention of tumor in mammalian cells. Cyclin-dependant kinase 4 (CDK4) is important in cell cycle regulation, as it controls the G1-S phase of the cell cycle. CDK4 has potential mitogenic and anti-mitogenic properties through phosphorylation of target proteins. We aimed at identifying a role of CDK4 IVS4-nt40 GA gene variant in benign and/or malignant tumors and in obesity-associated benign and/or malignant tumors in an Italian adult subject dataset. Methods: We recruited 263 unrelated Italian subjects: 106 subjects had at least one benign tumor and 46 subjects had at least one malignant tumor, while 116 subjects had at least two tumors and/or cancers. We collected BMI data for 90% of them: 186 subjects had a BMI (Source: Journ... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2303850 Sat, 28 Mar 2009 04:00:00 +0100 2303850 http://www.medworm.com/index.php?rid=2286520&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F41 Background: The study aimed to calculate chest-wall skin dose associated with different frequencies of bolus applications in post-mastectomy three-dimensional conformal radiotherapy (3D-CRT) and to provide detailed information in the selection of an appropriate bolus regimen in this clinical setting. Methods: CT-Simulation scans of 22 post-mastectomy patients were used. Chest wall for clinical target volume (CTV) and a volume including 2-mm surface thickness of the chest wall for skin structures were delineated. Precise PLAN 2.11 treatment planning system (TPS) was used for 3D-CRT planning. 50 Gy in 25 fractions were prescribed using tangential fields and 6-MV photons. Six different frequencies of bolus applications (0, 5, 10, 15, 20, and 25) were administered. Cumulative dose-volume histo... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2286520 Tue, 24 Mar 2009 04:00:00 +0100 2286520 http://www.medworm.com/index.php?rid=2275885&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F39 Studies on activated cell-signaling pathways responsible for neoplastic transformation are numerous in solid tumors and in adult leukemias. Despite of positive results in the evolution of pediatric hematopoietic neoplasias, there are some high-risk subtypes at worse prognosis. The aim of this study was to asses the expression and activation status of crucial proteins involved in cell-signaling pathways in order to identify molecular alterations responsible for the proliferation and/or escape from apoptosis of leukemic blasts. The quantitative and qualitative expression and activation of Erk-1, c-Jun, Caspase8, and Gadd45a was analyzed, by immunocytochemical (ICC) and western blotting methods, in bone marrow blasts of 72 patients affected by acute myeloid leukemia (AML), T-cell acute lympho... Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2275885 Thu, 19 Mar 2009 04:00:00 +0100 2275885 http://www.medworm.com/index.php?rid=2269461&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F38 Conclusions: CT perfusion is a useful and non invasive technique for evaluating brain neoplasms. Malignant and normal tissues can be accurately differentiated using perfusion map, with the aim of performing tumor diagnosis and grading, and follow-up analysis. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2269461 Mon, 16 Mar 2009 04:00:00 +0100 2269461 http://www.medworm.com/index.php?rid=2262404&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F37 Conclusions: Finally, we identified the combined Arg194Trp-Arg399Arg genotype of base excision repair gene XRCC1 that was associated with HNSCC and may have an impact on identification of a high-risk cancer population. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2262404 Fri, 13 Mar 2009 04:00:00 +0100 2262404 http://www.medworm.com/index.php?rid=2262405&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F36 Conclusions: MASEP GKRS is safe and effective in treating secretory pituitary adenomas. None of the patients in our study experienced injury to the optic apparatus or had other neuropathies related with gamma knife. MASEP GKRS may serve as a primary treatment method in some or as a salvage treatment in the others. However, treatment must be tailored to meet the patient's symptoms, tumor location, tumor morphometry, and overall health. Longer follow-up is required for a more complete assessment of late radioreaction and treatment efficacy. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2262405 Wed, 11 Mar 2009 04:00:00 +0100 2262405 http://www.medworm.com/index.php?rid=2250944&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F35 Conclusions: IGF-I reduction in the transition: Controls->MGUS->MM and changes observed over time suggest that IGF-I should be furtherly studied in future clinical trials as a possible monitoring marker for MM. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2250944 Tue, 10 Mar 2009 04:00:00 +0100 2250944 http://www.medworm.com/index.php?rid=2250945&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F34 Conclusions: The combination of epirubicin, oxaliplatin and docetaxel was found to be effective and well tolerated in patiens with metastatic gastric or GEJ adenocarcinoma and maybe an appropriate regimen to be used in the neoadjuvant setting and with molecularly targeted agents. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2250945 Mon, 09 Mar 2009 04:00:00 +0100 2250945 http://www.medworm.com/index.php?rid=2242294&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F33 Conclusions: Intravenous flurbiprofen axetil could provide better analgesia effects and few side effects to patients with refractory cancer pain. It could also increase analgesia effects when combining with anesthetic drugs in treatment of moderate or severe pain, especially breakthrough pain, and suit to patients who can not take oral drugs for the reason of constipation and psychosomatic symptoms. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2242294 Sat, 07 Mar 2009 05:00:00 +0100 2242294 http://www.medworm.com/index.php?rid=2242295&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F32 Conclusions: Understanding the contribution of GST gene polymorphisms and their interactions with other relevant factors may improve screening diagnostic assays for prostate cancer. We therefore discuss issues of study feasibility, study design, and statistical power, which should be taken into account in planning further trials. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2242295 Thu, 05 Mar 2009 05:00:00 +0100 2242295 http://www.medworm.com/index.php?rid=2234825&cid=s_37196_6_f&fid=37196&url=http%3A%2F%2Fwww.jeccr.com%2Fcontent%2F28%2F1%2F31 Conclusion: According to the results in this study, recombinant human endostatin adenovirus in combination with a low dose of cisplatin demonstrated apparent synergistic anti-tumor activity without marked toxicity. Thus, these observations may provide a rational alternative for lung cancer treatment. (Source: Journal of Experimental and Clinical Cancer Research) Journal of Experimental and Clinical Cancer Research journals http://www.medworm.com/rss/comments.php?id=2234825 Thu, 05 Mar 2009 05:00:00 +0100 2234825