Journal of Gastroenterology and Hepatology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Gastroenterology and Hepatology' source. Wed, 08 Feb 2012 16:28:23 +0100 Outcome and Complications of EUS Guided Pancreatic Pseudocyst Drainage Utilizing Combined Endoprosthesis and Naso‐cystic Drain. http://www.medworm.com/index.php?rid=5667836&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2012.07089.x Conclusion: EUS‐PPD with modified combined technique is safe and is associated with high success rate.© 2012 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5667836 Wed, 01 Feb 2012 05:00:00 +0100 5667836 A new look at antiplatelet agent‐related peptic ulcer: An update of prevention and treatment http://www.medworm.com/index.php?rid=5639009&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2012.07085.x AbstractPatients taking antiplatelet agent for the prevention of cardiovascular diseases who develop gastrointestinal bleeding represent a serious challenge in clinical practice. The initial step in reducing gastrointestinal risk of antiplatelet therapy is to assess whether the patient has a continued need for antiplatelet therapy. The next step is to eliminate the risk factors that may place the patient at increased gastrointestinal risk. In the management of bleeding ulcer patients with high‐risk stigmata of recent hemorrhage, resuming antiplatelet agents at 3‐5 days after the last dosing is a reasonable strategy. However, patients with low‐risk stigmata can keep taking antiplatelet agents immediately following endoscopy. In the management of aspirin‐related uncomplicated peptic ... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5639009 Sun, 29 Jan 2012 20:50:05 +0100 5639009 Hepatobiliary and Pancreatic: Detection of early hepatocellular carcinoma by enhanced magnetic resonance imaging http://www.medworm.com/index.php?rid=5609853&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06988.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609853 Fri, 20 Jan 2012 20:47:51 +0100 5609853 Hepatobiliary and Pancreatic: Aberrant hepatic arteries and pancreatic surgery http://www.medworm.com/index.php?rid=5609852&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06989.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609852 Fri, 20 Jan 2012 20:47:50 +0100 5609852 Gastrointestinal: Duodenal tumour and cutaneous skin lesions http://www.medworm.com/index.php?rid=5609851&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06992.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609851 Fri, 20 Jan 2012 20:47:48 +0100 5609851 Gastrointestinal: Acquired double pylorus; long‐term endoscopic observation http://www.medworm.com/index.php?rid=5609850&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06990.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609850 Fri, 20 Jan 2012 20:47:46 +0100 5609850 Gastrointestinal: Cavitating mesenteric lymph node syndrome as manifestation of anaplastic large cell lymphoma http://www.medworm.com/index.php?rid=5609849&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06991.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609849 Fri, 20 Jan 2012 20:47:44 +0100 5609849 Colorectal cancer screening practise is influenced by ethnicity of medical practitioner and patient http://www.medworm.com/index.php?rid=5609848&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06872.x Conclusions:  Considerable differences existed in GPs' CRC screening practises. Indications for use of FOBT and the subsequent investigation of a positive FOBT also varied according to GPs' ethnicity, independent of medical training. Patient's ethnicity and associated language and cultural barriers may affect screening uptake, which may negatively affect the health of immigrants. Resources and culture‐specific interventions are recommended to improve overall screening participation. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609848 Fri, 20 Jan 2012 20:47:39 +0100 5609848 Use of acid suppressive therapy more than 10 years after the endoscopic diagnosis of reflux esophagitis with specific emphasis to trademark and generic proton pump inhibitors http://www.medworm.com/index.php?rid=5609847&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06855.x Conclusion:  More than 10 years after the diagnosis, 22% of patients stopped using acid‐suppressive therapy. Only a minority (28%) were in clinical remission, associated with significantly higher satisfaction and compliance to therapy, as compared to their symptomatic counterparts. There was no difference in effect and usage of trademark versus generic medication preparations. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609847 Fri, 20 Jan 2012 20:47:31 +0100 5609847 Newly‐developed, forward‐viewing echoendoscope: A comparative pilot study to the standard echoendoscope in the imaging of abdominal organs and feasibility of endoscopic ultrasound‐guided interventions http://www.medworm.com/index.php?rid=5609846&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06923.x Conclusions:  There were no differences between the FV–CLA echoendoscope and the OV–CLA echoendoscope in visualization or image quality on upper EUS, except for the superior image quality of CHD using the FV–CLA echoendoscope. Therefore, the disadvantages of the FV–CLA echoendoscope appear minimal in light of the potential advantages. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609846 Fri, 20 Jan 2012 20:47:29 +0100 5609846 Success rate and cannulation time between precut sphincterotomy and double‐guidewire technique in truly difficult biliary cannulation http://www.medworm.com/index.php?rid=5609845&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06927.x Conclusion:  In truly difficult BC, the DG technique requires a significant shorter duration for BC, with a comparable success rate to the PS technique. The post‐procedure serum amylase level in the DG group was significantly higher, and there was a trend of more pancreatitis. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609845 Fri, 20 Jan 2012 20:47:27 +0100 5609845 Peroxisome proliferator‐activated receptor‐α agonist, Wy 14 643, improves metabolic indices, steatosis and ballooning in diabetic mice with non‐alcoholic steatohepatitis http://www.medworm.com/index.php?rid=5609844&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06939.x Conclusions:  Pharmacological activation of PPARα improves metabolic milieu, steatosis, ballooning, and combats NF‐κB and JNK activation, neutrophil and F4/80 macrophage recruitment in diabetes‐related NASH. However, persistent liver inflammation with high serum MCP1 due to unsuppressed adipose inflammation may limit PPARα agonists' efficacy as therapy for NASH. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609844 Fri, 20 Jan 2012 20:47:24 +0100 5609844 Early on‐treatment predictions of clinical outcomes using alpha‐fetoprotein and des‐gamma‐carboxy prothrombin responses in patients with advanced hepatocellular carcinoma http://www.medworm.com/index.php?rid=5609843&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06867.x Conclusions:  Early on‐treatment AFP response was predictive of OS in treatment‐naïve patients with advanced HCC receiving HAIC and CCRT as an initial treatment modality. Furthermore, DCP response was useful for predicting PFS in patients with CCRT. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609843 Fri, 20 Jan 2012 20:47:18 +0100 5609843 rtL180M mutation of hepatitis B virus is closely associated with frequent virological resistance to adefovir dipivoxil therapy http://www.medworm.com/index.php?rid=5609842&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06853.x Conclusions:  The rtL180M mutation of HBV, as well as a small decrease in HBV‐DNA after 1 year of treatment might be closely associated with frequent occurrence of virological resistance to ADV in patients with LAM‐resistant CHB. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609842 Fri, 20 Jan 2012 20:47:14 +0100 5609842 Laparoscopic splenectomy with interferon therapy in 100 hepatitis‐C‐virus‐cirrhotic patients with hypersplenism and thrombocytopenia http://www.medworm.com/index.php?rid=5609841&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06870.x Conclusions:  Lap‐Sp permits most patients with HCV cirrhosis and hypersplenism to receive sufficient IFN therapy. Therefore, Lap‐Sp can become a strong supportive surgery for cirrhotic patients who require antiviral therapy. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609841 Fri, 20 Jan 2012 20:47:11 +0100 5609841 Predicting response to therapy in chronic hepatitis C: An approach combining interleukin‐28B gene polymorphisms and clinical data http://www.medworm.com/index.php?rid=5609840&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06834.x Conclusions:  The rs12979860 SNP strongly predicts therapeutic response in CHC‐1 patients, and if associated with easy‐to‐obtain baseline criteria, provides a useful tool for the selection of candidates for antiviral therapy. IL28B haplotypes might improve the clinical usefulness of individual SNP. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609840 Fri, 20 Jan 2012 20:47:09 +0100 5609840 Serum immunoglobulin G4 associated with number and distribution of extrapancreatic lesions in type 1 autoimmune pancreatitis patients http://www.medworm.com/index.php?rid=5609839&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06933.x Conclusions:  Our findings indicated that serum IgG4 was useful in both the diagnosis of type 1 AIP and the detection of systemic EPL. Our finding may help the concept and diagnostic criteria of IgG4‐related disease with type 1 AIP. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609839 Fri, 20 Jan 2012 20:47:06 +0100 5609839 Liver disease in Viet Nam: Screening, surveillance, management and education: A 5‐year plan and call to action http://www.medworm.com/index.php?rid=5609838&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06974.x We report here the initial steps taken as part of a comprehensive approach to liver disease that will ultimately include nationwide education for health‐care providers, health educators, and the public; expansion of nationwide screening for hepatitis B and C followed by hepatitis B virus vaccination or treatment of chronic hepatitis B and/or hepatitis C; education about alcoholic liver disease; long‐term surveillance for liver cancer; reduction of infection transmission related to medical, commercial, and personal re‐use of contaminated needles, syringes, sharp instruments, razors, and inadequately sterilized medical equipment; and ongoing collection and analysis of data about the prevalence of all forms of liver disease and the results of the expanded screening, vaccination, and tre... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609838 Fri, 20 Jan 2012 20:46:58 +0100 5609838 Null genotype of glutathione S‐transferase Tl contributes to colorectal cancer risk in the Asian population: A meta‐analysis http://www.medworm.com/index.php?rid=5609837&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06920.x Conclusions:  This meta‐analysis suggests that the GSTT1 null genotype contributes to an increased colorectal cancer risk in the Asian population. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609837 Fri, 20 Jan 2012 20:46:57 +0100 5609837 Future candidates for indications of Helicobacter pylori eradication: Do the indications need to be revised? http://www.medworm.com/index.php?rid=5609836&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06961.x AbstractSince the discovery of Helicobacter pylori in 1982, the development of several treatment guidelines has allowed a consensus on the indications for H. pylori eradication. Beyond these currently accepted indications, including various upper gastrointestinal disorders and extragastric diseases, a significant amount of new information regarding H. pylori eradication is emerging. Certain types of acute gastritis, such as nodular gastritis, hypertrophic gastritis, Ménétrier's disease, hemorrhagic gastritis, and granulomatous gastritis are reversible after H. pylori eradication. Further, for chronic gastritis, closed‐type atrophic gastritis and complete‐type intestinal metaplasia appear to be more reversible after H. pylori eradication than open‐type atrophic gastritis and... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609836 Fri, 20 Jan 2012 20:46:51 +0100 5609836 Risk of non‐melanoma skin cancer with thiopurine use in inflammatory bowel disease http://www.medworm.com/index.php?rid=5609835&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07030.x See article in J. Gastroenterol. Hepatol. 2012; 27: 385–389. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609835 Fri, 20 Jan 2012 20:46:47 +0100 5609835 Magnetic nanoparticles for treatment of gastric cancer http://www.medworm.com/index.php?rid=5609834&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07031.x See article in J. Gastroenterol. Hepatol. 2012; 27: 406–411. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609834 Fri, 20 Jan 2012 20:46:46 +0100 5609834 Finding a role for Th17 cells in hepatitis C pathogenesis http://www.medworm.com/index.php?rid=5609833&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07033.x See article in J. Gastroenterol. Hepatol. 2012; 27: 273–278. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609833 Fri, 20 Jan 2012 20:46:44 +0100 5609833 Integrated bioinformatics analysis of microRNA expression profiles for an in‐depth understanding of pathogenic mechanisms in non‐alcoholic fatty liver disease http://www.medworm.com/index.php?rid=5609832&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07032.x See article in J. Gastroenterol. Hepatol. 2012; 27: 331–340. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609832 Fri, 20 Jan 2012 20:46:42 +0100 5609832 Forthcoming Articles http://www.medworm.com/index.php?rid=5609831&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2012.fp365.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609831 Fri, 20 Jan 2012 20:46:40 +0100 5609831 In this issue http://www.medworm.com/index.php?rid=5609830&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2012.info364.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5609830 Fri, 20 Jan 2012 20:46:38 +0100 5609830 Hepatobiliary and Pancreatic: Bleeding vaginal varices http://www.medworm.com/index.php?rid=5525829&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06982.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525829 Thu, 22 Dec 2011 09:16:43 +0100 5525829 Hepatobiliary and Pancreatic: Hepatosplenic gamma‐delta T‐cell lymphoma http://www.medworm.com/index.php?rid=5525828&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06983.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525828 Thu, 22 Dec 2011 09:16:41 +0100 5525828 Gastrointestinal: Giant hemorrhagic adrenal pseudocyst http://www.medworm.com/index.php?rid=5525827&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06955.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525827 Thu, 22 Dec 2011 09:16:39 +0100 5525827 Gastrointestinal: the role of multidetector computer tomography in diagnosis of pneumatosis cystoides intestinalis http://www.medworm.com/index.php?rid=5525826&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06952.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525826 Thu, 22 Dec 2011 09:16:37 +0100 5525826 Gastrointestinal: Refractory ulcerative colitis complicated by colonic stricturing endometriosis http://www.medworm.com/index.php?rid=5525825&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06956.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525825 Thu, 22 Dec 2011 09:16:35 +0100 5525825 Transitional features of histologic type of non‐alcoholic fatty liver disease in Korean young men http://www.medworm.com/index.php?rid=5525823&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06895.x Conclusion:  Most Korean young men with NAFLD turned out to have borderline or definite NASH. More than half of the NASH cases showed overlap type in Korean young men. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525823 Thu, 22 Dec 2011 09:16:27 +0100 5525823 Prediction of improved liver function after balloon‐occluded retrograde transvenous obliteration: Relation to hepatic vein pressure gradient http://www.medworm.com/index.php?rid=5525822&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06835.x Conclusion:  An elevated HVPG after B‐RTO is one aspect of the effect of liver function, and an HVPG increase of ≥ 20% from baseline is a predictive factor for obtaining an improvement of liver function. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525822 Thu, 22 Dec 2011 09:16:25 +0100 5525822 Normal liver elasticity values using acoustic radiation force impulse imaging: A prospective study in healthy living liver and kidney donors http://www.medworm.com/index.php?rid=5525821&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06814.x Conclusions:  We identified the normal range of ARFI velocity as 0.85–1.25 m/s and found that it was not significantly influenced by BMI, gender, and age. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525821 Thu, 22 Dec 2011 09:16:23 +0100 5525821 Toll‐like receptor 2 monoclonal antibody or/and Toll‐like receptor 4 monoclonal antibody increase counts of Lactobacilli and Bifidobacteria in dextran sulfate sodium‐induced colitis in mice http://www.medworm.com/index.php?rid=5525819&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06839.x Conclusions:  TLR2mAb and TLR4mAb can suppress the development of DSS‐induced colitis and increase counts of Lactobacilli and Bifidobacteria. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525819 Thu, 22 Dec 2011 09:16:20 +0100 5525819 CYP2C19 genotypes determine the efficacy of on‐demand therapy of pantoprazole for reflux esophagitis as Los‐Angeles grades C and D http://www.medworm.com/index.php?rid=5525818&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06848.x Conclusion:  For RE‐CD with complete healing after continuous pantoprazole, the successful shift to ODT is determined by the CYP2C19 genotypes of the patients. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525818 Thu, 22 Dec 2011 09:16:18 +0100 5525818 Detection of single‐nucleotide polymorphisms in the intron 9 region of the nucleotide oligomerization domain‐1 gene in ulcerative colitis patients of North India http://www.medworm.com/index.php?rid=5525817&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06832.x Conclusion:  Our study has revealed a polymorphism association in the LRR domain of the NOD1 gene with the severity of UC disease. This might be due to disruption of the LRR region critical for NOD1‐mediated bacterial sensing. A gene‐wide, haplotype‐based approach shows that GTTG haplotype carriers are overrepresented in UC patients, and that could increase the risk of the disease. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525817 Thu, 22 Dec 2011 09:16:16 +0100 5525817 Optimal follow‐up time to determine the sustained virological response in patients with chronic hepatitis C receiving pegylated‐interferon and ribavirin http://www.medworm.com/index.php?rid=5525815&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06802.x Conclusion:  The assessment of serum HCV‐RNA FW+12, using the highly sensitive real‐time PCR assay, is almost as effective as FW+24 to predict SVR. However, there are false negatives in female patients with a high viral load of genotype Ib when the SVR is predicted by FW+12. The current standard with FW+24 is reasonable, but the assessment of serum HCV‐RNA FW+12 may be effective in most patients. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525815 Thu, 22 Dec 2011 09:16:08 +0100 5525815 Large‐scale randomized clinical study on functional dyspepsia treatment with mosapride or teprenone: Japan Mosapride Mega‐Study (JMMS) http://www.medworm.com/index.php?rid=5525814&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06949.x Conclusions:  Endoscopic evaluation at patients' presentation was effective to find active lesions and to improve FD symptoms. Mosapride was more favorably accepted than teprenone by the patients with sufficient safety and efficacy. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525814 Thu, 22 Dec 2011 09:16:06 +0100 5525814 Increasing the duration of dual amoxicillin plus omeprazole Helicobacter pylori eradication to 6 weeks: A pilot study http://www.medworm.com/index.php?rid=5525813&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06876.x Conclusion:  Despite the theory and pre‐existing data from Japan, in the USA, prolonging the duration of dual amoxicillin‐PPI therapy did not improve treatment outcome in 90% or more of our patients. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525813 Thu, 22 Dec 2011 09:16:04 +0100 5525813 Colorectal cancer mouse models: Integrating inflammation and the stroma http://www.medworm.com/index.php?rid=5525811&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06883.x AbstractSequences of molecular events that initiate and advance the progression of human colorectal cancer (CRC) are becoming clearer. Accepting that these events, once they are in place, accumulate over time, rapid disease progression might be expected. Yet CRC usually develops slowly over decades. Emerging insights suggest that the tumor cell microenvironment encompassing fibroblasts and endothelial and immune cells dictate when, whether, and how malignancies progress. Signaling pathways that affect the microenvironment and the inflammatory response seem to play a central role in CRC. Indeed, some of these pathways directly regulate the stem/progenitor cell niche at the base of the crypt; it now appears that the survival and growth of neoplastic cells often relies upon their subverted en... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525811 Thu, 22 Dec 2011 09:16:01 +0100 5525811 Mucins in inflammatory bowel diseases and colorectal cancer http://www.medworm.com/index.php?rid=5525810&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06909.x AbstractThe gastrointestinal tract is protected by a mucus barrier with both secreted and cell‐surface mucins contributing to the exclusion of luminal microbes and toxins. Alterations in the structure and/or quantity of mucins alter the barrier function of mucus and could play roles in initiating and maintaining mucosal inflammation in inflammatory bowel diseases (IBD), and in driving cancer development in the intestine. The aim of this review is to focus on the roles of the mucins in IBD. The polymorphisms of mucin genes that have been associated with susceptibility to IBD, and alterations in mucin expression as well as factors that regulate production of the mucins in IBD, are summarized. Data from animal models of intestinal inflammation, which support the importance of mucins in IBD ... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525810 Thu, 22 Dec 2011 09:15:59 +0100 5525810 A thank you note from the Editor‐in‐Chief http://www.medworm.com/index.php?rid=5525809&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06993.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525809 Thu, 22 Dec 2011 09:15:53 +0100 5525809 Seeking an optimal eradication therapy for Helicobacter pylori infection http://www.medworm.com/index.php?rid=5525807&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06953.x See article in J. Gastroenterol. Hepatol. 2012; 27: 59–61. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525807 Thu, 22 Dec 2011 09:15:51 +0100 5525807 Histological features of non‐alcoholic fatty liver disease: What is important? http://www.medworm.com/index.php?rid=5525806&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06957.x See article in J. Gastroenterol. Hepatol. 2012; 27: 142–148. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525806 Thu, 22 Dec 2011 09:15:49 +0100 5525806 Balloon‐occluded retrograde transvenous obliteration: One step beyond obliteration of gastric varices http://www.medworm.com/index.php?rid=5525805&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06954.x See article in J. Gastroenterol. Hepatol. 2012; 27: 137–141. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525805 Thu, 22 Dec 2011 09:15:48 +0100 5525805 How does hepatitis B virus infection react to hepatocellular carcinoma treatment? http://www.medworm.com/index.php?rid=5525804&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06950.x See article in J. Gastroenterol. Hepatol. 2012; 27: 158–164. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525804 Thu, 22 Dec 2011 09:15:46 +0100 5525804 Forthcoming Articles http://www.medworm.com/index.php?rid=5525803&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.fp358.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525803 Thu, 22 Dec 2011 09:15:44 +0100 5525803 In this issue http://www.medworm.com/index.php?rid=5525802&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.info357.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525802 Thu, 22 Dec 2011 09:15:42 +0100 5525802 CD14 expression and Kupffer cell dysfunction in nonalcoholic steatohepatitis: SPIO‐MRI and pathologic correlation http://www.medworm.com/index.php?rid=5525779&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07057.x Conclusions: KC phagocytic function evaluated with SPIO‐MRI correlated with histopathological severity and number of CD14‐positive KCs. These results support the concept that KC phagocytic dysfunction contributes to the pathogenesis of NASH. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525779 Thu, 22 Dec 2011 09:11:53 +0100 5525779 When to Use Biological Agents in Inflammatory Bowel Disease http://www.medworm.com/index.php?rid=5525780&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07056.x ABSTRACTThe use of biological agents in inflammatory bowel diseases across the Asia‐Pacific region is increasing. As new molecules and targets are identified, knowledge regarding the indications, utility, optimization and adverse effects of biological agents grows. Careful patient selection, attention to communication and patient education will maximize the benefit of these drugs. Tertiary referral centers with specific interest in inflammatory bowel diseases and experience play an important role in their use. There is enormous opportunity for patients to benefit from biological agents in the therapy of Crohn's disease and ulcerative colitis. Use of these agents has been studied across a variety of indications and populations, and at different stages in the disease course. Failure to res... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5525780 Wed, 21 Dec 2011 05:00:00 +0100 5525780 Gallbladder cancer: Can newer insights improve the outcome? http://www.medworm.com/index.php?rid=5505863&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07048.x ABSTRACTGallbladder cancer (GBC) is the leading cause of cancer related mortality in certain geographic areas. Most of the patients with GBC have advanced disease at presentation, precluding curative resection resulting in a dismal prognosis. However, recent advances in the understanding of its epidemiology and pathogenesis coupled with development of newer diagnostic tools and therapeutic options, has resulted in enhanced optimism towards the management of the disease.The leading risk factors are gallstones, advancing age, female gender, anomalous pancreaticobiliary ductal junction, certain ethnic groups and geographic populations. Advances in radiological imaging and advent of endoscopic ultrasound have facilitated early detection and accurate staging of the tumor. A high index of suspic... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5505863 Wed, 14 Dec 2011 05:00:00 +0100 5505863 Low expression of DAB2IP contributes to malignant development and poor prognosis in hepatocellular carcinoma http://www.medworm.com/index.php?rid=5505862&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07049.x Conclusion DAB2IP is a valuable marker for progression of HCC patients. Down‐regulation of DAB2IP is associated with poor prognosis in HCC patients. DAB2IP silence alone is sufficient to promote HCC cell proliferation and invasion in vitro. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5505862 Wed, 14 Dec 2011 05:00:00 +0100 5505862 Viral response at six months is associated with treatment outcome of adefovir add‐on therapy for lamivudine‐resistance http://www.medworm.com/index.php?rid=5505861&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07050.x ConclusionsPre‐treatment HBV DNA level and viral response at 6 months is associated with treatment outcome for adefovir‐add on therapy in lamivudine resistance. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5505861 Wed, 14 Dec 2011 05:00:00 +0100 5505861 The Efficacy and Tolerability of Pegylated Interferon‐α‐2a in Chronic Hepatitis B: A Multicenter Clinical Experience http://www.medworm.com/index.php?rid=5505860&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07051.x Conclusion In everyday clinical practice PEG‐IFN therapy in CHB is well tolerated and can achieve a similar efficacy to that seen in large controlled trials. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5505860 Wed, 14 Dec 2011 05:00:00 +0100 5505860 JGHF Marshall & Warren Lecture: Anti‐platelet therapy and managing ulcer risk http://www.medworm.com/index.php?rid=5477229&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07029.x AbstractLow‐dose aspirin (ASA) has emerged as one of the most important causes of peptic ulcer bleeding in developed countries. Among the risk factors of ASA‐associated ulcer bleeding, Helicobacter pylori infection is one of the few that is treatable. Recent evidence showed that among patients with a history of ASA‐associated ulcer bleeding, the long‐term incidence of recurrent bleeding with ASA use is low after eradication of H. pylori alone. Thus, test‐and‐treat H. pylori is a potentially useful strategy for ASA users with high ulcer risk. However, the risk of bleeding is further increased by combing other anti‐platelet drugs (e.g. clopidogrel) with ASA in acute coronary syndromes and coronary stent placement. There is good evidence that co‐therapy with a proton‐pump in... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477229 Tue, 06 Dec 2011 05:00:00 +0100 5477229 Resection for Hepatocellular Carcinoma: Is it justifiable to restrict this to the AASLD/BCLC criteria? http://www.medworm.com/index.php?rid=5477228&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07034.x AbstractHepatocellular Carcinoma (HCC) is an important cancer worldwide. The main curative treatment modality is surgical resection although only a minority of afflicted patients are amendable because of poor liver function reserve or extensive disease at the time of diagnosis. The selection criteria for surgical resection, however, are variable and frequently appear to be center‐specific. Further, they are influenced by rapidly evolving data on the outcomes of surgical resection and other emerging modalities of treatment. Recently, two major international practice guidelines on the management of HCC were published at about the same time, namely those of the American Association for the Study of the Liver (AASLD), and of the Asia‐Pacific Association for the Study of the Liver (APASL). ... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477228 Tue, 06 Dec 2011 05:00:00 +0100 5477228 Impact of pegylated interferon alfa‐2a treatment on mental health during recent hepatitis C virus infection http://www.medworm.com/index.php?rid=5477227&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07035.x Conclusions: Although depression at enrolment and during treatment was common among participants with recent HCV, neither impacted SVR. Participants with poor social functioning may be most at risk of developing depression during HCV therapy. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477227 Tue, 06 Dec 2011 05:00:00 +0100 5477227 Severe acute liver injury associated with lumiracoxib http://www.medworm.com/index.php?rid=5477226&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07036.x Conclusions: Lumiracoxib can be associated with severe liver injury. The presence of a variety of positive auto‐antibodies suggests an altered immune response may be contributory. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477226 Tue, 06 Dec 2011 05:00:00 +0100 5477226 Asian Consensus Report on Functional Dyspepsia http://www.medworm.com/index.php?rid=5477225&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07037.x Conclusions This consensus developed by Asian experts shows distinctive features of functional dyspepsia in Asia and will provide a guide to the diagnosis and management of functional dyspepsia for Asian primary care physicians. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477225 Tue, 06 Dec 2011 05:00:00 +0100 5477225 Effect of endoscopic screening at 1‐year intervals on the clinicopathologic characteristics and treatment of gastric cancer in South Korea http://www.medworm.com/index.php?rid=5477224&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07038.x Conclusions: Endoscopic screening for GC at 1‐year intervals would be beneficial for patients with severe IM in South Korea; this method could detect EGC for which the curative modality would be ESD. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477224 Tue, 06 Dec 2011 05:00:00 +0100 5477224 Risk factors for perforation and delayed bleeding associated with endoscopic submucosal dissection for early gastric neoplasms; analysis of 1123 lesions http://www.medworm.com/index.php?rid=5477223&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07039.x Conclusions: This study demonstrated risk factors for perforation and delayed bleeding associated with ESD. Furthermore, it was clarified that perforation and delayed bleeding influenced to post‐procedure results and prognosis after ESD. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477223 Tue, 06 Dec 2011 05:00:00 +0100 5477223 Prevalence of the JAK2V617F mutation in Chinese patients with Budd‐Chiari syndrome and portal vein thrombosis ‐ A prospective study http://www.medworm.com/index.php?rid=5477222&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07040.x Conclusions: The low prevalence of the JAK2V617F mutation in patients with BCS suggests that myeloproliferative neoplasm should be an uncommon etiological factor of BCS in China. Routine screening for the JAK2V617F mutation might be recommended in non‐malignant and non‐cirrhotic patients with PVT, but not in cirrhotic patients with PVT. The coexistence of higher PLT and splenomegaly might be closely associated with the JAK2V617F mutation. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477222 Tue, 06 Dec 2011 05:00:00 +0100 5477222 Management of T1 colorectal carcinoma with special reference to criteria for curative endoscopic resection http://www.medworm.com/index.php?rid=5477221&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07041.x Conclusions: Even in cases of colorectal carcinoma with deep submucosal invasion, the risk of lymph node metastasis is minimal under certain conditions. Thus, even for such cases, endoscopic incisional biopsy can be suitable if complete en bloc resection is achieved. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477221 Tue, 06 Dec 2011 05:00:00 +0100 5477221 Symptoms and Quality of Life in Underweight Gastroesophageal Reflux Disease Patients and Therapeutic Responses to Proton Pump Inhibitors http://www.medworm.com/index.php?rid=5477220&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07042.x Conclusions: Japanese GERD patients are often obese, as reported previously, but some GERD patients are underweight. Baseline symptoms and QOL in underweight GERD patients tended to be more severe than in normal‐weight patients, but therapeutic response with PPIs was about the same as in normal‐weight or obese patients. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477220 Tue, 06 Dec 2011 05:00:00 +0100 5477220 Preservation of Nutritional‐status in Patients with Refractory Ascites due to Hepatic Cirrhosis who are Undergoing Repeated Paracentesis http://www.medworm.com/index.php?rid=5477219&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07043.x Conclusions: Post‐paracentesis parenteral‐nutritional‐support with a balanced oral diet and an evening protein snack appears to be the best care protocol for patients with liver‐cirrhosis that has been complicated by refractory‐ascites. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477219 Tue, 06 Dec 2011 05:00:00 +0100 5477219 Bone marrow cells: important role on neovascularization of hepatocelluar carcinoma http://www.medworm.com/index.php?rid=5477218&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07044.x Conclusion Mobilized BMCs played an important role in tumor vasculogenesis of HCC. Combined blockading of bone marrow‐mediated vasculogenesis may improve the efficacy of current therapy to HCC patients. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477218 Tue, 06 Dec 2011 05:00:00 +0100 5477218 Genetic variation in PNPLA3 but not APOC3 influences liver fat in NAFLD http://www.medworm.com/index.php?rid=5477217&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07045.x Conclusion Genetic variants in PNPLA3 but not APOC3 contribute to the variance in liver fat content due to NAFLD. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477217 Tue, 06 Dec 2011 05:00:00 +0100 5477217 Characteristics of intestinal lamina propria dendritic cells in a mouse model of postinfectious irritable bowel syndrome http://www.medworm.com/index.php?rid=5477216&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07046.x Conclusions: The hypothesis was supported that the phenotype and function of LPDCs changed in the development of PI‐IBS, which induced the maintenance of intestinal mucosal immune activation and might provide a clue for the treatment of the disease. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477216 Tue, 06 Dec 2011 05:00:00 +0100 5477216 The discovery of critical host factor, IL‐28B, associated with response to HCV treatment http://www.medworm.com/index.php?rid=5505859&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07054.x AbstractChronic hepatitis C affects 2.2 ‐ 3% of the world population (130 million ‐ 170 million). Pegylated interferon‐alpha (PEG‐IFN‐α) in combination with ribavirin (RBV), the approved and standard therapy, leads to viral eradication in about 50% of treated patients. In 2009, genome‐wide association studies (GWAS) identified host genetic variation to be critical for predicting treatment response and spontaneous clearance in patients infected with hepatitis C virus (HCV). A correlated set of polymorphisms in the region of the interleukin‐28B (IL‐28B) gene on chromosome 19, coding for interferon (IFN)‐λ3 were associated with clearance of genotype 1 hepatitis C virus (HCV) in patients treated with PEG‐IFN‐α and RBV. The same polymorphisms were subsequently associate... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5505859 Thu, 01 Dec 2011 05:00:00 +0100 5505859 An Economic Analysis between Entecavir and Lamivudine for the Treatment of Chronic Hepatitis B in Hong Kong http://www.medworm.com/index.php?rid=5477215&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.07047.x Conclusions Based on the recommended cost‐effectiveness threshold of World Health Organization, entecavir is considered cost‐effective compared with lamivudine in treating CHB in Hong Kong when long term medical consequences were considered. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5477215 Thu, 01 Dec 2011 05:00:00 +0100 5477215 A meta‐analysis: The Treatment of High‐Frequency Gastric Electrical Stimulation for Gastroparesis http://www.medworm.com/index.php?rid=5469573&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06999.x Conclusions: (1) Based on this meta‐analysis the substantial and significant improvement of symptoms and gastric emptying and the good safety we observed, indicate that high‐frequency GES is an effective and safe method for treating refractory gastroparesis. (2) DG patients seem the most responsive to GES both subjectively and objectively while the IG and PSG subgroups are less responsive and need further research. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5469573 Thu, 01 Dec 2011 05:00:00 +0100 5469573 The role of the renin‐angiotensin system in gastric oncogenesis http://www.medworm.com/index.php?rid=5441810&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06964.x AbstractThe renin‐angiotensin system (RAS) plays an important role not only in homeostasis but also in carcinogenesis. Recent epidemiological studies suggest that hypertensive patients with up‐regulated systemic RAS functions are at a significantly increased risk for the subsequent development of cancers with poor outcomes, and moreover that RAS inhibitors reduce tumor development, progression, and metastasis. Notably, Helicobacter pylori infection, one of the major predictors of gastric carcinogenesis, generally leads to RAS component overexpression, as exemplified by that of angiotensin I, angiotensin II, angiotensin I converting enzyme and angiotensin II receptor. Gastric mucosal RAS expression gradually increases with time after H. pylori infection with respect to the severity of i... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5441810 Fri, 25 Nov 2011 09:05:57 +0100 5441810 Hepatobiliary and Pancreatic: Niemann–Pick disease http://www.medworm.com/index.php?rid=5432309&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06935.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5432309 Tue, 22 Nov 2011 09:13:40 +0100 5432309 Gastrointestinal: A gastrointestinal stromal tumour (GIST) arising in a Meckel's diverticulum http://www.medworm.com/index.php?rid=5432308&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06937.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5432308 Tue, 22 Nov 2011 09:13:38 +0100 5432308 Gastrointestinal: Asymptomatic spontaneous isolated dissection of superior mesenteric artery diagnosed incidentally http://www.medworm.com/index.php?rid=5432307&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06936.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5432307 Tue, 22 Nov 2011 09:13:37 +0100 5432307 Hepatitis C recurrence after liver transplantation: Has the human leukocyte antigen mismatching at individual loci a role? http://www.medworm.com/index.php?rid=5432306&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06772.x Conclusions:  In conclusion, this large study did not demonstrate any relationship between the total score of HLA mismatches and HCV‐recurrence. Contrarily a significant relationship between the individual scores of HLA mismatches (HLA‐A3, HLA‐B35, HLA‐DR3, HLA‐DR7, HLA‐DQ2, HLA‐DQ2‐0) and the recurrence of HCV were observed. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5432306 Tue, 22 Nov 2011 09:13:28 +0100 5432306 Risk factors for hepatocellular carcinoma in a cohort infected with hepatitis B or C http://www.medworm.com/index.php?rid=5432305&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06785.x Conclusion:  This large population‐based study confirms known risk factors for HCC. The association with older age highlights the potential impact of HBV and HCV screening of at‐risk groups and early clinical assessment. Additional research is required to evaluate the impact of improving antiviral therapy on HCC risk. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5432305 Tue, 22 Nov 2011 09:13:25 +0100 5432305 Contrast‐enhanced ultrasonography using Sonazoid to evaluate changes in hepatic hemodynamics in acute liver injury http://www.medworm.com/index.php?rid=5432304&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06790.x Conclusion:  CEUS using Sonazoid is a useful method to estimate the changes in hepatic hemodynamics in patients with ALI. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5432304 Tue, 22 Nov 2011 09:13:24 +0100 5432304 Variation in human genetic polymorphisms, their association with Helicobacter pylori acquisition and gastric cancer in a multi‐ethnic country http://www.medworm.com/index.php?rid=5432303&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06799.x Conclusion:  These findings contribute to the understanding of the genetic variation between ethnicities, which may influence H. pylori susceptibility and the outcome of infection. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5432303 Tue, 22 Nov 2011 09:13:19 +0100 5432303 Endoscopic ultrasound‐guided fine‐needle aspiration of lesions near the aortoiliac bifurcation via an upper gastrointestinal approach http://www.medworm.com/index.php?rid=5432302&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06787.x Conclusions:  The aortoiliac bifurcation was visible in all patients by transduodenal EUS scanning. FNA of the legions near the aortoiliac bifurcation was possible in five of six patients by using either the transgastric or transduodenal approach. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5432302 Tue, 22 Nov 2011 09:13:15 +0100 5432302 Current status on the diagnosis and management of pancreatic cysts in the Asia–Pacific region: Role of endoscopic ultrasound http://www.medworm.com/index.php?rid=5432301&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06884.x AbstractEndoscopic ultrasound (EUS) and EUS‐guided fine‐needle aspiration (EUS‐FNA) play increasingly prominent roles in the diagnosis and management of pancreatic cysts. The Asian Consortium of Endoscopic Ultrasound was recently formed to conduct collaborative research in this area. This is a review of literature on true pancreatic cysts. Due to the lack of systematic studies, there are no robust data on the true incidence of pancreatic cystic lesions in Asia and any change in over the recent decades. Certain EUS morphological features have been used to predict particular types of pancreatic cysts. Pancreatic cyst fluid viscosity, cytology, pancreatic enzymes, and tumor markers, in particular carcinoembryonic antigen, can aid in the diagnosis of pancreatic cysts. Hemorrhage and infe... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5432301 Tue, 22 Nov 2011 09:13:12 +0100 5432301 Can tertiary prevention of hepatocellular carcinoma be achieved by nucleos(t)ide analogs therapy of hepatitis B? http://www.medworm.com/index.php?rid=5432300&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06931.x See article in J. Gastroenterol. Hepatol. 2011; 26: 1380–1388. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5432300 Tue, 22 Nov 2011 09:13:11 +0100 5432300 Microsatellite instability: Detection and management in sporadic colorectal cancer http://www.medworm.com/index.php?rid=5432299&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06932.x See article in J. Gastroenterol. Hepatol. 2011; 26: 1733–1739. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5432299 Tue, 22 Nov 2011 09:13:09 +0100 5432299 Forthcoming Articles http://www.medworm.com/index.php?rid=5432298&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.fp294.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5432298 Tue, 22 Nov 2011 09:13:07 +0100 5432298 In this issue http://www.medworm.com/index.php?rid=5432297&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2010.info293.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5432297 Tue, 22 Nov 2011 09:13:06 +0100 5432297 Infliximab or Cyclosporine for Acute Severe Ulcerative Colitis: A retrospective analysis http://www.medworm.com/index.php?rid=5422951&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06958.x Conclusions Infliximab improved clinical outcomes compared to the previous use of intravenous cyclosporine in patients admitted with steroid‐refractory acute severe Ulcerative Colitis. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422951 Fri, 18 Nov 2011 05:00:00 +0100 5422951 Diagnostic Yield of Dual‐Phase CT Enterography in Patients with Obscure Gastrointestinal Bleeding and a Nondiagnostic Capsule Endoscopy http://www.medworm.com/index.php?rid=5422950&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06959.x Conclusions: In patients with a nondiagnostic capsule endoscopy examination, CT enterography is useful for detecting a source of gastrointestinal bleeding in patients with overt, but not occult, obscure gastrointestinal bleeding. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422950 Fri, 18 Nov 2011 05:00:00 +0100 5422950 Future candidates for indications of Helicobacter pylori eradication – do the indications need to be revised? http://www.medworm.com/index.php?rid=5422949&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06961.x AbstractSince the discovery of Helicobacter pylori in 1982, the development of several treatment guidelines has allowed a consensus on the indications for H. pylori eradication. Beyond these currently accepted indications, including various upper gastrointestinal disorders and extragastric diseases, a significant amount of new information regarding H. pylori eradication is emerging. Certain types of acute gastritis, such as nodular gastritis, hypertrophic gastritis, Ménétrier's disease, hemorrhagic gastritis, and granulomatous gastritis are reversible after H. pylori eradication. Further, for chronic gastritis, closed‐type atrophic gastritis and complete‐type intestinal metaplasia appear to be more reversible after H. pylori eradication than open‐type atrophic gastritis and incompl... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422949 Fri, 18 Nov 2011 05:00:00 +0100 5422949 The “normal” liver stiffness values differ between men and women: A prospective study for healthy living liver and kidney donors in a native Korean population http://www.medworm.com/index.php?rid=5422948&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06962.x Conclusions: An independent gender effect on LS values was confirmed. Thus, gender‐specific references should be used for effective screening based on LS measurements. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422948 Fri, 18 Nov 2011 05:00:00 +0100 5422948 Severity and Timing of Progression Predict Refractoriness to Transarterial Chemoembolization in Hepatocellular Carcinoma http://www.medworm.com/index.php?rid=5422947&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06963.x Conclusions: SP‐free survival can be regarded as an endpoint for TACE refractoriness. Development of progression or need for three sessions of TACE within the first 6 months could be predictive of TACE refractoriness. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422947 Fri, 18 Nov 2011 05:00:00 +0100 5422947 An evaluation of the adverse effect of premature discontinuation of pegylated interferon alpha‐2b and ribavirin treatment for chronic hepatitis C virus infection: Results from Kyushu University Liver Disease Study (KULDS) http://www.medworm.com/index.php?rid=5422946&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06965.x Conclusion:Premature discontinuation due to the adverse effects of PEG‐IFN alpha‐2b and RBV treatment by patients with chronic HCV infection is mainly due to neuropsychiatric symptoms and is more common for older than for younger patients. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422946 Fri, 18 Nov 2011 05:00:00 +0100 5422946 Preconditioning donor liver with Nodosin perfusion lessens rat ischemia reperfusion injury via heme oxygenase‐1 upregulation http://www.medworm.com/index.php?rid=5422945&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06966.x Conclusions: This study suggests that preconditioning with Nodosin perfusion provides a potential protective effect through inducing HO‐1 expression to attenuate I/R injury in liver transplantation. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422945 Fri, 18 Nov 2011 05:00:00 +0100 5422945 The role of VEGF in angiodysplasia: an intervention study with thalidomide http://www.medworm.com/index.php?rid=5422944&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06967.x Conclusions VEGF may play an important role in the pathogenesis of angiodysplasia. Thalidomide can suppress VEGF, either induced by HIF‐1α or bFGF. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422944 Fri, 18 Nov 2011 05:00:00 +0100 5422944 Effect of bed head elevation during sleep in symptomatic patients of nocturnal gastro esophageal reflux http://www.medworm.com/index.php?rid=5422943&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06968.x Conclusions: Bed head elevation reduced esophageal acid exposure and acid clearance time in nocturnal (supine) refluers and led to some relief from heart burn and sleep disturbance. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422943 Fri, 18 Nov 2011 05:00:00 +0100 5422943 High dose esomeprazole is required for intra‐esophageal acid control in GORD patients with hiatus hernia http://www.medworm.com/index.php?rid=5422942&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06969.x Conclusions: The standard‐dose of esomeprazole fails to normalize the esophageal pH in almost 50% of patients with hiatus hernia, in whom the “double‐dose” esomeprazole therapy is required. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422942 Fri, 18 Nov 2011 05:00:00 +0100 5422942 A Potent HBsAg Response to Treatment of HBeAg‐positive Chronic hepatitis B with Interferon alpha plus a nucleos(t)ide analogue http://www.medworm.com/index.php?rid=5422941&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06970.x Conclusions: Extended treatment with interferon alpha in combination with a nucleos(t)ide analogue in patients with HBeAg‐positive appears to be a promising approach for achieving high rate of HBsAg clearance ‐ the closest outcome to cure. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422941 Fri, 18 Nov 2011 05:00:00 +0100 5422941 Acute‐on‐chronic liver failure in chronic hepatitis B http://www.medworm.com/index.php?rid=5422940&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06971.x AbstractAcute‐on‐chronic liver failure (ACLF) in chronic hepatitis B (CHB) is most commonly caused by acute severe exacerbation of CHB. The pathophysiology of ACLF in CHB is still poorly understood. Despite the identification of important predisposing factor and prognostic markers, ACLF in CHB remains a disease associated with high mortality. The majority of studies using nucleoside analogue therapy did not show any significant improvement in survival, although larger prospective studies are needed. Liver transplantation is the definitive treatment for ACLF in CHB. The challenge ahead would be prognosticating cases with favorable or unfavorable outcomes in order to streamline patients for early transplantation or for medical therapy. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422940 Fri, 18 Nov 2011 05:00:00 +0100 5422940 Tumor local chemohyperthermia using docetaxel‐embedded magnetoliposomes: interaction of chemotherapy and hyperthermia http://www.medworm.com/index.php?rid=5422939&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06972.x Conclusion: The antitumor effect of this treatment derives from a combination of hyperthermia and chemotherapy locally in the tumor. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422939 Fri, 18 Nov 2011 05:00:00 +0100 5422939 Expression profile of genes involved in pathogenesis of paediatric Crohn's disease http://www.medworm.com/index.php?rid=5422938&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06973.x Conclusion: The retrieval of 28 genes previously reported in association with adult CD emphasises the importance of these genes in the paediatric setting. The observed up‐regulation of REG1A and MMP2, and their known impact on cell proliferation and extracellular matrix remodelling, agrees with the clinical behaviour of the disease. Moreover, the expressions of bacterial‐ and virus‐related genes in our CD patient tissues support the concept that microbial agents are important in the aetiopathogenesis of CD. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422938 Fri, 18 Nov 2011 05:00:00 +0100 5422938 Liver Disease in Viet Nam: Screening, Surveillance, Management and Education http://www.medworm.com/index.php?rid=5422937&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06974.x We report here the initial steps taken as part of a comprehensive approach to liver disease that will ultimately include nationwide education for healthcare providers, health educators, and the public; expansion of nationwide screening for hepatitis B and C followed by HBV vaccination or treatment of chronic HBV and/or HCV; education about alcoholic liver disease; long‐term surveillance for liver cancer; reduction of infection transmission related to medical, commercial, and personal re‐use of contaminated needles, syringes, sharp instruments, razors, and inadequately sterilized medical equipment; and ongoing collection and analysis of data about the prevalence of all forms of liver disease and the results of the expanded screening, vaccination, and treatment programs. We report the be... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422937 Fri, 18 Nov 2011 05:00:00 +0100 5422937 Predicting the efficacy of proton pump inhibitors in patients with non‐erosive reflux disease before therapy using dual‐channel 24‐h esophageal pH monitoring http://www.medworm.com/index.php?rid=5422936&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06975.x Conclusions: Pre‐therapeutic pH monitoring in the lower and mid‐esophagus is useful for predicting the efficacy of PPIs in NERD patients. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422936 Fri, 18 Nov 2011 05:00:00 +0100 5422936 Clinical impact of HFE mutations in Japanese patients with chronic hepatitis C http://www.medworm.com/index.php?rid=5422935&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06976.x Conclusions: The H63D mutation has little impact on the clinical characteristics of CHC, but is related to favorable response to PEG‐IFN plus RBV therapy, particularly in patients with the TT allele in IL28B. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422935 Fri, 18 Nov 2011 05:00:00 +0100 5422935 Clinical outcomes of endoscopic submucosal dissection and endoscopic mucosal resection for laterally spreading tumors larger than 20 mm http://www.medworm.com/index.php?rid=5422934&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06977.x Conclusions: As for the safety, ESD/hybrid ESD is equivalent to EMR/EPMR. ESD/hybrid ESD was feasible technique for en‐bloc resection and showed no local recurrence. Although local recurrences associated with EMR/EPMR were seen, which were conducted based on our indication criteria, all local recurrences could obtain complete cure by additional endoscopic treatment. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422934 Fri, 18 Nov 2011 05:00:00 +0100 5422934 Association of tumor necrosis factor‐alpha gene promoter polymorphism at sites ‐308 and ‐238 with NAFLD: A meta‐analysis http://www.medworm.com/index.php?rid=5422933&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06978.x Conclusion This meta‐analysis suggested that TNF‐α gene promoter polymorphism at position ‐238 but not ‐308 might be a risk factor for NAFLD. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422933 Fri, 18 Nov 2011 05:00:00 +0100 5422933 Characterization of microRNA expression profiles associated with hepatitis B virus replication and clearance in vivo and in vitro http://www.medworm.com/index.php?rid=5422932&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06979.x Conclusions: HBV replication alters miRNA expression profiles and impairs interferon inducible miRNA response in HepG2 cells. The miRNA expression pattern of PBMCs in CHB patients with interferon therapy can be associated with their therapeutic outcome. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422932 Fri, 18 Nov 2011 05:00:00 +0100 5422932 COX‐2 and Akt mediate multiple growth factor‐induced epithelial‐mesenchymal transition in human hepatocellular carcinoma http://www.medworm.com/index.php?rid=5422931&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06980.x Conclusions: Multiple growth factors induce EMT in HCC. COX‐2 and Akt may mediate EMT associated development and progression of HCC and molecular targeting of COX‐2 and Akt may be an effective therapeutic or chemopreventative strategy in advanced and metastatic HCC. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422931 Fri, 18 Nov 2011 05:00:00 +0100 5422931 Screening of de novo tumors after liver transplantation http://www.medworm.com/index.php?rid=5422930&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06981.x AbstractDe novo malignancies are frequent complications after liver transplantation. They are one of the leading causes of late death. Some authors have reported promising results following implementation of extensive cancer surveillance programs. Screening protocols might benefit patients by providing a diagnosis at an earlier stage when tumors may be cured. These protocols should be based on the specific risk factors of every patient. Unfortunately, the scientific evidence supporting screening protocols is still very weak both in the general population and in the transplant patients. On this basis, there is not enough evidence to recommend routine screening for all liver transplant recipients, apart from the recommendations accepted for general population. Multicenter studies in selected... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422930 Fri, 18 Nov 2011 05:00:00 +0100 5422930 Comparison of Clinical Characteristics and Management of Inflammatory Bowel Disease in Hong Kong versus Melbourne http://www.medworm.com/index.php?rid=5422929&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06984.x Conclusions: IBD in HK is diagnosed at an older age, and had more complicated disease behavior than in Melbourne. Medical therapy, however, was less intense in HK. These differences may relate to real differences in disease or delayed diagnosis due to late presentation and less disease recognition in HK. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422929 Fri, 18 Nov 2011 05:00:00 +0100 5422929 Effect of Pretreatment with Lactobacillus gasseri OLL2716 on First‐line Helicobacter pylori Eradication Therapy http://www.medworm.com/index.php?rid=5422928&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06985.x Conclusion: This study confirmed that the major cause of treatment failure is resistance to clarithromycin. A 4‐week treatment with L. gasseri‐containing yogurt improves the efficacy of triple therapy in patients with H. pylori infection. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422928 Fri, 18 Nov 2011 05:00:00 +0100 5422928 Inflammatory stress exacerbates hepatic cholesterol accumulation via disrupting cellular cholesterol export http://www.medworm.com/index.php?rid=5422927&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06986.x Conclusions: Inflammation disrupted PPAR‐LXR‐CYP7A1/ABCA1‐mediated bile acid synthesis and cholesterol efflux resulting in exacerbated cholesterol accumulation in livers of C57BL/6J mice and HepG2 cells. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422927 Fri, 18 Nov 2011 05:00:00 +0100 5422927 A meta‐analysis for evaluating the accuracy of endoscopy with narrow band imaging in detecting colorectal adenomas http://www.medworm.com/index.php?rid=5422926&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06987.x Conclusions Endoscopy with NBI seems to improve the detection of flat adenomas, particularly with high‐definition technology, but prolongs the withdrawn time. These results indicate that endoscopy routinely using the NBI system for the surveillance of adenomas may be recommended after the technique is further modified. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5422926 Tue, 01 Nov 2011 04:00:00 +0100 5422926 Hepatobiliary and Pancreatic: Clip migration after laparoscopic cholecystectomy http://www.medworm.com/index.php?rid=5336853&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06906.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336853 Sat, 22 Oct 2011 09:58:07 +0100 5336853 Hepatobiliary and Pancreatic: Blocked metal biliary stent http://www.medworm.com/index.php?rid=5336852&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06905.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336852 Sat, 22 Oct 2011 09:58:03 +0100 5336852 Gastrointestinal: Atypical hyperplastic gastric polyposis: A case report and brief review of the literature http://www.medworm.com/index.php?rid=5336851&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06907.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336851 Sat, 22 Oct 2011 09:57:49 +0100 5336851 Gastrointestinal: Tuberculosis of the sigmoid colon—a cautionary tale http://www.medworm.com/index.php?rid=5336850&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06899.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336850 Sat, 22 Oct 2011 09:57:27 +0100 5336850 Gastrointestinal: Endoscopic septoplasty for Zenker's diverticulum in a nonagenarian http://www.medworm.com/index.php?rid=5336849&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06904.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336849 Sat, 22 Oct 2011 09:57:22 +0100 5336849 Helicobacter pylori induces promoter hypermethylation and downregulates gene expression of IRX1 transcription factor on human gastric mucosa http://www.medworm.com/index.php?rid=5336848&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06808.x Conclusions:  This study firstly demonstrated that H. pylori infection contributes to IRX1 promoter methylation on gastric mucosa. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336848 Sat, 22 Oct 2011 09:57:15 +0100 5336848 Negative hepatitis B envelope antigen predicts intrahepatic recurrence in hepatitis B virus‐related hepatocellular carcinoma after ablation therapy http://www.medworm.com/index.php?rid=5336847&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06777.x Conclusions:  These findings show that HBeAg‐negativity and serum AFP levels were associated with late intrahepatic recurrence of HCC, implicating HBeAg‐negativity as a risk factor for de novo recurrence after percutaneous ablation in HBV‐related HCC. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336847 Sat, 22 Oct 2011 09:56:30 +0100 5336847 Underexpressed microRNA‐199b‐5p targets Hypoxia‐Inducible Factor‐1α in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients http://www.medworm.com/index.php?rid=5336846&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06758.x Conclusions:  Underexpressed miR‐199b, which may be via the upregulation of Hif1α in HCCs, is inversely correlated with survival and directly correlated with the malignant status of HCC patients. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336846 Sat, 22 Oct 2011 09:56:24 +0100 5336846 Hepatocellular carcinoma and vitamin D: A review http://www.medworm.com/index.php?rid=5336845&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06892.x AbstractThe non‐classical actions of vitamin D, namely antiproliferation, pro‐differentiation, pro‐apoptosis, anti‐inflammation, and immune regulation, have received great attention during the past decade. Increasing evidence from epidemiological studies showing the inverse association between vitamin D status and incidence of many forms of cancer as well as biochemical studies has suggested that vitamin D deficiency may play a role in the cause and progression of these types of cancer. Recently, vitamin D and its analogs have been deemed as potential regimen to treat a variety of cancers alone or in combination with other drugs. Although, the epidemiologic evidence regarding the association of vitamin D and hepatocellular carcinoma (HCC) is still inconclusive, biochemical evidence... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336845 Sat, 22 Oct 2011 09:55:54 +0100 5336845 MicroRNA, hypoxic stress and hepatocellular carcinoma: Future directions http://www.medworm.com/index.php?rid=5336844&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06903.x See article in J. Gastroenterol. Hepatol. 2011; 26: 1630–1637. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336844 Sat, 22 Oct 2011 09:55:41 +0100 5336844 Sorafenib, doesn't it have any competitor in advanced hepatocellular carcinoma? http://www.medworm.com/index.php?rid=5336843&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06901.x See article in J. Gastroenterol. Hepatol. 2011; 26: 1612–1618. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336843 Sat, 22 Oct 2011 09:55:38 +0100 5336843 Endoscopic resection for mucosal neoplasia: Pushing the boundaries, confronting the reality http://www.medworm.com/index.php?rid=5336842&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06900.x See article in J. Gastroenterol. Hepatol. 2011; 26: 1619–1625. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336842 Sat, 22 Oct 2011 09:55:32 +0100 5336842 Gastric cancer in young patients: Clues on a possible separate entity requiring a watchful approach http://www.medworm.com/index.php?rid=5336841&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06902.x See article in J. Gastroenterol. Hepatol. 2011; 26: 1626–1629. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336841 Sat, 22 Oct 2011 09:55:29 +0100 5336841 Forthcoming Articles http://www.medworm.com/index.php?rid=5336840&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.fp287.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336840 Sat, 22 Oct 2011 09:55:26 +0100 5336840 In this issue http://www.medworm.com/index.php?rid=5336839&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2010.info286.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5336839 Sat, 22 Oct 2011 09:55:23 +0100 5336839 Immunopathogenesis and prognostic immune markers of chronic hepatitis B virus infection http://www.medworm.com/index.php?rid=5324523&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06940.x AbstractHost immune responses induced by hepatitis B virus (HBV) infection not only substantially drive disease progression, but also significantly influence efficacy of antiviral treatments in HBV‐infected individuals. Therefore, it is important to fully understand the course of immune pathogenesis and to find efficient immunological markers that can predict the disease progression of chronic HBV infection. This review introduces the current progress in clinical immunology and analyzes the mechanisms of antiviral effects and liver injury which are induced by both innate and adaptive immune responses. The recently identified immunological markers indicated to be closely correlated with disease progression and antiviral efficacy during HBV infection are also summarized. Careful monitoring... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5324523 Mon, 17 Oct 2011 04:00:00 +0100 5324523 A Matched Case‐control Study Comparing Endoscopic Submucosal Dissection and Endoscopic Mucosal Resection for Colorectal Tumors http://www.medworm.com/index.php?rid=5324522&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06942.x Conclusions: ESD is a promising technique for the treatment of colorectal tumors, giving an excellent outcome in comparison with EMR. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5324522 Mon, 17 Oct 2011 04:00:00 +0100 5324522 Lipopolysaccharide enhances transforming growth factor β1‐induced PDGF‐B expression in bile duct epithelial cells http://www.medworm.com/index.php?rid=5324521&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06941.x Conclusions: The results indicate that LPS activation of NFκB and JNK2 enhances TGFβ1‐induced PDGF‐B expression in BDECs. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5324521 Mon, 17 Oct 2011 04:00:00 +0100 5324521 The validity and reliability of the malay‐language translation of the rome iii diagnostic questionnaire for irritable bowel syndrome http://www.medworm.com/index.php?rid=5324520&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06943.x Conclusion The translated Malay language Rome III IBS diagnostic questionnaire and the questionnaires for Red Flags and Psychosocial Alarm symptoms are valid and reliable. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5324520 Mon, 17 Oct 2011 04:00:00 +0100 5324520 Adherence to follow‐up after a positive fecal occult blood test in an organized colorectal cancer screening program in Korea, 2004‐2008 http://www.medworm.com/index.php?rid=5324519&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06944.x Conclusion: These findings suggest that targeting participants for follow‐up, based on age and previous screening history, could be a good way to improve the follow‐up rate. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5324519 Mon, 17 Oct 2011 04:00:00 +0100 5324519 Oral manifestations of gastroesophageal reflux disease http://www.medworm.com/index.php?rid=5324518&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06945.x AbstractNumerous case‐control and other studies involving confirmation of gastroesophageal reflux disease (GERD) by esophageal pH‐metry and the assessment of dental erosions have shown significant associations between the two conditions in both adults and children. By contrast, when asked to vote on whether GERD may cause dental erosions, only 42% of physicians strongly agreed that such an association existed in adults, and just 12.5% strongly agreed for children, respectively in two global consensus reports. Part of this divergence between the perceptions of physicians and the findings of research publications may reflect a general lack of oral health education during medical training, and cursory oral examinations being made under less‐than‐ideal conditions. Adequate salivary sec... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5324518 Mon, 17 Oct 2011 04:00:00 +0100 5324518 Decreased Anti‐HCV titer and associated factors in Chronic Hepatitis C patients after Sustained Virological Response: A prospective study http://www.medworm.com/index.php?rid=5324517&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06946.x Conclusions: Anti‐HCV titers decreased annually during long‐term follow‐up after SVR. Higher pretreatment platelet count, IFN regimen and mild fibrosis were associated with decreased anti‐HCV titers. However, only a few cases achieved seroreversion. All RIBA bands decreased significantly after long‐term follow‐up. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5324517 Mon, 17 Oct 2011 04:00:00 +0100 5324517 Clinical outcomes of radiofrequency ablation and surgical resection for small hepatocellular carcinoma: A meta‐analysis http://www.medworm.com/index.php?rid=5324516&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06947.x Conclusions: RES was superior to RFA in the treatment of HCC. However, the findings have to be carefully interpreted due to the lower level of evidence. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5324516 Mon, 17 Oct 2011 04:00:00 +0100 5324516 Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study http://www.medworm.com/index.php?rid=5324515&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06948.x Conclusion: SNPs of CCND2, RAD23B, GRP78, CEP164, MDM2, and ALDH2 genes were significantly associated with development and recurrence of HCC in Japanese patients with HCV. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5324515 Mon, 17 Oct 2011 04:00:00 +0100 5324515 A large‐scale, randomized clinical study on functional dyspepsia treatment with mosapride or teprenone: Japan Mosapride Mega‐Study (JMMS) http://www.medworm.com/index.php?rid=5324514&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06949.x Conclusions: Endoscopic evaluation at patients’ presentation was effective to find active lesions and to improve FD symptoms. Mosapride was more favorably accepted than teprenone by the patients with sufficient safety and efficacy. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5324514 Mon, 17 Oct 2011 04:00:00 +0100 5324514 Late evening snack – Exploiting a period of anabolic opportunity in cirrhosis http://www.medworm.com/index.php?rid=5324513&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06951.x Conclusions: LES holds the most promise as an intervention to reverse anabolic resistance and sarcopenia of cirrhosis with improved quality of life in patients with cirrhosis. Long term benefit and improved survival need critical evaluation. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5324513 Sat, 01 Oct 2011 04:00:00 +0100 5324513 Hepatobiliary and Pancreatic: Splenic vein aneurysm with portal hypertension and hypersplenism http://www.medworm.com/index.php?rid=5251385&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06857.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5251385 Sun, 25 Sep 2011 21:07:25 +0100 5251385 Hepatobiliary and Pancreatic: Traumatic hepatic arterioportal fistula http://www.medworm.com/index.php?rid=5251384&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06858.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5251384 Sun, 25 Sep 2011 21:07:23 +0100 5251384 Gastrointestinal: Beware of the painful rectum http://www.medworm.com/index.php?rid=5251383&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06861.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5251383 Sun, 25 Sep 2011 21:07:22 +0100 5251383 Gastrointestinal: Metastatic ocular melanoma causing massive hepatomegaly http://www.medworm.com/index.php?rid=5251382&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06859.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5251382 Sun, 25 Sep 2011 21:07:20 +0100 5251382 Gastrointestinal: Rare presentation of appendicitis: Amyand's hernia http://www.medworm.com/index.php?rid=5251381&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06860.x (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5251381 Sun, 25 Sep 2011 21:07:18 +0100 5251381 Impact of introduction of wire‐guided cannulation in therapeutic biliary endoscopic retrograde cholangiopancreatography http://www.medworm.com/index.php?rid=5251380&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06788.x Conclusions:  The introduction of WGC was effective in the first 50 cases and did not increase the rate of PEP in biliary therapeutic ERCP. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5251380 Sun, 25 Sep 2011 21:07:12 +0100 5251380 Intrahepatic response markers in chronic hepatitis B patients treated with peginterferon alpha‐2a and adefovir http://www.medworm.com/index.php?rid=5251379&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06766.x Conclusions:  At end of treatment in HBeAg positive patients, intrahepatic cccDNA and total intrahepatic HBV DNA were predictive for SVR. In HBeAg negative patients a proportion of < 7.5% HBsAg positive hepatocytes at end of treatment was a strong predictor for SVR. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5251379 Sun, 25 Sep 2011 21:07:07 +0100 5251379 Human dendritic cells transfected with amplified MUC1 mRNA stimulate cytotoxic T lymphocyte responses against pancreatic cancer in vitro http://www.medworm.com/index.php?rid=5251378&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06778.x Conclusion:  The CTL responses stimulated by DCs transfected with MUC1 mRNA could only recognize and lyse HLA‐A2+/MUC1+ PC and other target cells under restriction by MHC class I‐specific antigen presentation, providing a preclinical rationale for using MUC1 as a target structure for immunotherapeutic strategies against PC. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5251378 Sun, 25 Sep 2011 21:07:03 +0100 5251378 EUS in exploring the etiology of mild acute biliary pancreatitis with a negative finding of biliary origin by conventional radiological methods http://www.medworm.com/index.php?rid=5251377&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06755.x Conclusion:  The results suggest that EUS is helpful in the identification of the etiology of mild biliary pancreatitis when conventional radiological imaging is negative or equivocal. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5251377 Sun, 25 Sep 2011 21:07:00 +0100 5251377 Update of fecal markers of inflammation in inflammatory bowel disease http://www.medworm.com/index.php?rid=5251376&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06846.x AbstractThe diagnosis, prognosis, and assessment of disease activity of inflammatory bowel disease (IBD) require investigating clinical, radiological, and histological criteria, as well as serum inflammatory markers. However, a range of fecal inflammatory markers now appears to have the potential to greatly assist in these processes. Calprotectin, a prominent neutrophil protein, was identified two decades ago as a potentially revolutionary marker for IBD. Following this discovery, numerous additional markers, including S100A12, lactoferrin, and M2‐pyruvate kinase, have also been suggested as novel markers of IBD. In the present study, we provide an up‐to‐date review of fecal markers of IBD, and further, provide a novel analysis of each of these fecal markers in severe ulcerative coli... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5251376 Sun, 25 Sep 2011 21:06:58 +0100 5251376 Management of cancer risk in Barrett's esophagus http://www.medworm.com/index.php?rid=5251375&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06768.x AbstractThe importance of Barrett's esophagus (BE) lies in its potential to give rise to esophageal adenocarcinoma (EAC), postulated to be through a series of progressive degrees of dysplasia; from intestinal metaplasia to low‐grade dysplasia, high‐grade dysplasia, and subsequently, to cancer. The management strategies for the detection and treatment of dysplasia and early esophageal cancer on a background of BE have changed significantly in the last few decades, with the emergence of newer and less invasive non‐operative alternatives. This review aims to outline BE and its relation to EAC, the rationale and cost‐effectiveness of both screening and surveillance programs, methods of diagnosing and identifying dysplasia and early cancer in Barrett's, and approaches to individualizing... Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5251375 Sun, 25 Sep 2011 21:06:56 +0100 5251375 Association of 8q24.21 loci with the risk of colorectal cancer: A systematic review and meta‐analysis http://www.medworm.com/index.php?rid=5251374&cid=s_30386_17_f&fid=30386&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1746.2011.06831.x Conclusion:  Our data suggested that the rs6983267 G > T polymorphism is a risk factor for CRC in Asians, Europeans, and Americans with European ancestry. (Source: Journal of Gastroenterology and Hepatology) Journal of Gastroenterology and Hepatology journals http://www.medworm.com/rss/comments.php?id=5251374 Sun, 25 Sep 2011 21:06:55 +0100 5251374