Journal of Gastroenterology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Gastroenterology' source. Wed, 08 Feb 2012 16:28:22 +0100 Analysis of colorectal cancer morphology in relation to sex, age, location, and family history http://www.medworm.com/index.php?rid=5620770&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F31375010133r5480%2F Conclusion  Location is the factor that has the most influence on tumor morphology. The results support the idea that different carcinogenic mechanisms may be involved in the right and left colon. Age is the most important determinant for the presence of multiple tumors and is a crucial factor for the aggressiveness of the disease. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-16DOI 10.1007/s00535-011-0520-9Authors Sam Ghazi, Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, 14186 Stockholm, SwedenUlrik Lindforss, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Solna, 17176 Stockholm, SwedenGreger Lindberg, De... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5620770 Tue, 17 Jan 2012 07:13:59 +0100 5620770 Reply to the letter by L. Czakó et al. regarding “Endoscopic submucosal dissection as a treatment for gastric noninvasive neoplasia: a multicenter study by Osaka University ESD Study Group” http://www.medworm.com/index.php?rid=5583175&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F674l2ng7v8363798%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-1DOI 10.1007/s00535-011-0526-3Authors Motohiko Kato, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanTsutomu Nishida, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanTetsuo Takehara, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 (Source: Journal of Gastroenterology) Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5583175 Tue, 10 Jan 2012 17:01:21 +0100 5583175 Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection http://www.medworm.com/index.php?rid=5583176&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqv24562053v840h4%2F Conclusions  These results suggest that the incidence of HCC in HBV patients with cirrhosis can be reduced in those with an MVR induced by consecutive LAM treatment. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-9DOI 10.1007/s00535-011-0522-7Authors Mika Kurokawa, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine 2-2, Yamadaoka, Suita, Osaka 565-0871, JapanNaoki Hiramatsu, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine 2-2, Yamadaoka, Suita, Osaka 565-0871, JapanTsugiko Oze, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine 2-2, Yamadaoka, Suita, Osaka 565-0871, JapanTakayuki Yakushijin, De... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5583176 Tue, 10 Jan 2012 06:42:03 +0100 5583176 Predictive factors of local recurrence after endoscopic piecemeal mucosal resection http://www.medworm.com/index.php?rid=5572742&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff563104l26741168%2F Conclusion  The removal of 5 or more neoplasm specimens is an independent risk factor for local recurrence after EPMR. Careful colonoscopic surveillance should be performed after multiple piecemeal resection. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-6DOI 10.1007/s00535-011-0524-5Authors Taku Sakamoto, Endoscopy Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, JapanTakahisa Matsuda, Endoscopy Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, JapanYosuke Otake, Endoscopy Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, JapanTakeshi Nakajima, Endoscopy Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, JapanYutaka Saito, Endoscopy Divisi... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5572742 Thu, 05 Jan 2012 17:06:15 +0100 5572742 Head-to-head comparison of transient elastography (TE), real-time tissue elastography (RTE), and acoustic radiation force impulse (ARFI) imaging in the diagnosis of liver fibrosis http://www.medworm.com/index.php?rid=5572744&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmn8t03240014q06t%2F Conclusions  TE and ARFI provide high diagnostic accuracy in the diagnosis of cirrhosis. When feasible, TE may perform better than RTE and ARFI in predicting fibrosis and significant fibrosis, but larger studies are needed. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-9DOI 10.1007/s00535-011-0509-4Authors Silvia Colombo, Hepatology Unit, Treviglio Hospital, Piazza Ospedale n.1, 24047 Treviglio (Bergamo), ItalyMarco Buonocore, Hepatology Unit, Treviglio Hospital, Piazza Ospedale n.1, 24047 Treviglio (Bergamo), ItalyAnna Del Poggio, Hepatology Unit, Treviglio Hospital, Piazza Ospedale n.1, 24047 Treviglio (Bergamo), ItalyCarlo Jamoletti, Hepatology Unit, Treviglio Hospital, Piazza Ospedale n.1, 24047 Treviglio (Bergam... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5572744 Thu, 05 Jan 2012 17:06:14 +0100 5572744 Risk factors of early re-bleeding and mortality in patients with ruptured gastric varices and concomitant hepatocellular carcinoma http://www.medworm.com/index.php?rid=5572743&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw2v1l5156l0v1ur3%2F Conclusion  Patients with GVB and concomitant HCC are associated with poor outcomes. Recently developed HCC, a high MELD score, active bleeding, advanced tumor stage, and elevated alanine transaminase are poor prognostic predictors. Apart from pharmacological and endoscopic treatments for GVB, careful investigation of a recently developed HCC in these patients is mandatory. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-9DOI 10.1007/s00535-011-0518-3Authors Chen-Jung Chang, School of Medicine, National Yang Ming University, Taipei, TaiwanMing-Chih Hou, School of Medicine, National Yang Ming University, Taipei, TaiwanWei-Chih Liao, School of Medicine, National Yang Ming University, Taipei, TaiwanFa-Yauh Lee, School of Medicine, Nationa... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5572743 Thu, 05 Jan 2012 17:06:14 +0100 5572743 The inflammatory network in the gastrointestinal tumor microenvironment: lessons from mouse models http://www.medworm.com/index.php?rid=5572746&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F745m600w57215u55%2F Abstract  Accumulating evidence has indicated that inflammatory responses are important for cancer development. Epidemiological studies have shown that regular use of non-steroidal anti-inflammatory drugs (NSAIDs) reduces the risk of colon cancer development. Subsequently, mouse genetic studies have shown that cyclooxygenase (COX)-2, one of the target molecules of NSAIDs, and its downstream product, prostaglandin E2 (PGE2), play an important role in gastrointestinal tumorigenesis. Bacterial infection stimulates the Toll-like receptor (TLR)/MyD88 pathway in tumor tissues, which leads to the induction of COX-2 in stromal cells, including macrophages. Induction of the COX-2/PGE2 pathway in tumor stroma is important for the development and maintenance of an inflammatory microenv... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5572746 Wed, 04 Jan 2012 16:48:30 +0100 5572746 Shall we use endoscopic submucosal dissection for every gastric neoplasia? http://www.medworm.com/index.php?rid=5572745&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff181036hp35x5114%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00535-011-0525-4Authors László Czakó, First Department of Medicine, University of Szeged, P.O. Box: 427, Szeged, 6701 HungaryViktória Terzin, First Department of Medicine, University of Szeged, P.O. Box: 427, Szeged, 6701 HungaryTibor Szalóki, Department of Gastroenterology, Ödön Jávorszky Hospital, Vác, Hungary Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 (Source: Journal of Gastroenterology) Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5572745 Wed, 04 Jan 2012 16:48:30 +0100 5572745 Update on biologic pathways in inflammatory bowel disease and their therapeutic relevance http://www.medworm.com/index.php?rid=5572747&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy384604104l3883l%2F Abstract  Results of recent genetic and immunologic studies have brought to the forefront several biologic pathways that allow for a better understanding of the mechanisms of tissue homeostasis, on the one hand, and inflammatory bowel disease (IBD) on the other. The explosion of research activity as a result of these newly identified targets is bringing the pathogenesis of these complex disorders into focus as well as creating new therapeutic opportunities. The greatest advances with perhaps the largest impact on our understanding of the etiology of Crohn’s disease are those related to bacterial sensing, such as through nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and its relationships to autophagy and the unfolded protein response as a consequenc... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5572747 Wed, 04 Jan 2012 07:02:22 +0100 5572747 Neutrophil gelatinase-associated lipocalin (NGAL) in inflammatory bowel disease: association with pathophysiology of inflammation, established markers, and disease activity http://www.medworm.com/index.php?rid=5552848&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8506p76647117712%2F Conclusions  Serum NGAL is elevated particularly in active IBD and correlates with established markers of inflammation and disease activity, implicating its role in the pathophysiology of IBD. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-12DOI 10.1007/s00535-011-0516-5Authors K. A. Oikonomou, Department of Gastroenterology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Mezourlo, 41110 Larissa, GreeceA. N. Kapsoritakis, Department of Gastroenterology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Mezourlo, 41110 Larissa, GreeceC. Theodoridou, Department of Immunology and Histocompatibility, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, GreeceD. Kara... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5552848 Mon, 26 Dec 2011 16:45:38 +0100 5552848 Oral symptoms including dental erosion in gastroesophageal reflux disease are associated with decreased salivary flow volume and swallowing function http://www.medworm.com/index.php?rid=5552849&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp3260rp71602g02l%2F Conclusions  Oral symptoms in GERD are likely to be associated with impaired salivary flow volume or swallowing function. Treatment for the oral dryness induced by reduced salivary flow volume and rehabilitation for swallowing function could be indicated in patients with GERD. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-9DOI 10.1007/s00535-011-0515-6Authors Hiroo Yoshikawa, Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, JapanKenji Furuta, Department of Internal Medicine, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, JapanMayumi Ueno, Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, 89... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5552849 Mon, 26 Dec 2011 16:45:36 +0100 5552849 Value of post-vascular phase (Kupffer imaging) by contrast-enhanced ultrasonography using Sonazoid in the detection of hepatocellular carcinoma http://www.medworm.com/index.php?rid=5552850&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Feq2254t4727g6583%2F Conclusions  Kupffer imaging by CEUS with Sonazoid showed very high specificity but rather mediocre sensitivity for HCC detection. CEUS is highly suitable for confirmatory diagnosis of HCC; however, caution should be exercised in reaching a diagnosis based only on CEUS. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-9DOI 10.1007/s00535-011-0512-9Authors Eriko Goto, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanRyota Masuzaki, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanRyosuke Tateishi, Department of Gastroenterology, Graduate School of Medicine, T... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5552850 Mon, 26 Dec 2011 16:45:34 +0100 5552850 Regulatory T cells expanded by rapamycin in vitro suppress colitis in an experimental mouse model http://www.medworm.com/index.php?rid=5545053&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnr52854706p68661%2F Conclusions  We demonstrated, for the first time, that CD4+ T cells expanded with rapamycin in vitro suppressed colitis. Therefore, rapamycin-expanded Treg transfer therapy is expected to be efficacious for inflammatory bowel disease. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-11DOI 10.1007/s00535-011-0502-yAuthors Haruei Ogino, Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 JapanKazuhiko Nakamura, Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 JapanTsutomu Iwasa, Department of Medicine and Bioregulatory Science, Graduate Sch... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5545053 Wed, 21 Dec 2011 20:06:54 +0100 5545053 Glucans from the edible mushroom Pleurotus pulmonarius inhibit colitis-associated colon carcinogenesis in mice http://www.medworm.com/index.php?rid=5538546&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmv47735878115138%2F Conclusions  We conclude that P. pulmonarius FBE and ME inhibit colitis-associated colon carcinogenesis induced in mice through the modulation of cell proliferation, induction of apoptosis, and inhibition of inflammation. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-15DOI 10.1007/s00535-011-0514-7Authors Iris Lavi, Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, 76100 Rehovot, IsraelLili Nimri, Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, 76100 Rehovot, IsraelDana Levinson, Department of Pla... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5538546 Tue, 20 Dec 2011 16:46:53 +0100 5538546 Risk factors for hepatocellular carcinoma in Japanese patients with autoimmune hepatitis type 1 http://www.medworm.com/index.php?rid=5538547&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcu18464326656j1h%2F Conclusion  This retrospective study showed that cirrhosis at diagnosis of AIH and abnormal ALT at final observation were independently associated with HCC development. It is important to pay attention to the presence of cirrhosis at diagnosis of AIH and to normalize ALT. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-8DOI 10.1007/s00535-011-0519-2Authors Teruko Hino-Arinaga, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, JapanTatsuya Ide, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, JapanRyoko Kuromatsu, Division of Gastroenterology, Departmen... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5538547 Tue, 20 Dec 2011 16:46:52 +0100 5538547 Risk factors for pancreatic stone formation in autoimmune pancreatitis over a long-term course http://www.medworm.com/index.php?rid=5538548&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F626125m085384011%2F Conclusions  A primary risk factor for pancreatic stone formation in AIP was narrowing of both Wirsung’s and Santorini’s ducts, which most presumably led to pancreatic juice stasis and stone development. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-8DOI 10.1007/s00535-011-0510-yAuthors Masahiro Maruyama, Department of Gastroenterology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621 JapanNorikazu Arakura, Endoscopic Examination Center, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621 JapanYayoi Ozaki, Department of Gastroenterology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621 JapanTakayuki Watanabe, Department of Gastroenterology, Shinshu... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5538548 Tue, 20 Dec 2011 06:43:22 +0100 5538548 Early evaluation of transcatheter arterial chemoembolization-refractory hepatocellular carcinoma http://www.medworm.com/index.php?rid=5538549&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm85346781j744264%2F Conclusions  Evaluating the TE at 1 week after TACE is useful for the early diagnosis of TACE-refractory HCC and allows alternative treatment options, such as sorafenib, to be employed before the disease progresses. Content Type Journal ArticleCategory Rapid CommunicationPages 1-4DOI 10.1007/s00535-011-0511-xAuthors Kenya Yamanaka, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507 JapanEtsuro Hatano, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507 JapanKoji Kitamura, Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507 JapanTaku Iida, Department of Surger... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5538549 Tue, 20 Dec 2011 06:43:21 +0100 5538549 Therapeutic effects of famotidine on chronic symptomatic gastritis: subgroup analysis from FUTURE study http://www.medworm.com/index.php?rid=5538550&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv384824506354677%2F Conclusion  Famotidine is effective to relieve abdominal symptoms and improve QOL, not only in patients with Rome III-defined FD, but also in those with chronic symptomatic gastritis. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-10DOI 10.1007/s00535-011-0503-xAuthors Yoshikazu Kinoshita, Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, JapanTsutomu Chiba, Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, JapanFUTURE study group Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 (Source: Journal of Gastroenterology) Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5538550 Tue, 20 Dec 2011 06:43:20 +0100 5538550 Small bowel injury induced by selective cyclooxygenase-2 inhibitors: a prospective, double-blind, randomized clinical trial comparing celecoxib and meloxicam http://www.medworm.com/index.php?rid=5515916&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx269381406115320%2F Conclusions  Selective COX-2 inhibitors are not completely safe for the small bowel. The mucosal lesions may be less severe with celecoxib than with meloxicam. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-7DOI 10.1007/s00535-011-0501-zAuthors Yuji Maehata, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 JapanMotohiro Esaki, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 JapanToshibumi Morishita, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-858... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5515916 Wed, 14 Dec 2011 16:31:37 +0100 5515916 Possible utility of MRI using Gd-EOB-DTPA for estimating liver functional reserve http://www.medworm.com/index.php?rid=5515915&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F72030w54777m50uq%2F Conclusion  EOB-MRI represents a practical and reliable imaging technique that may be used to estimate regional liver functional reserve in the clinical setting. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-7DOI 10.1007/s00535-011-0513-8Authors Tohru Utsunomiya, Department of Surgery, The University of Tokushima, 13-18-15 Kuramoto-cho, Tokushima, 770-8503 JapanMitsuo Shimada, Department of Surgery, The University of Tokushima, 13-18-15 Kuramoto-cho, Tokushima, 770-8503 JapanJun Hanaoka, Department of Surgery, The University of Tokushima, 13-18-15 Kuramoto-cho, Tokushima, 770-8503 JapanMami Kanamoto, Department of Surgery, The University of Tokushima, 13-18-15 Kuramoto-cho, Tokushima, 770-8503 JapanTetsuya Ikemoto, D... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5515915 Wed, 14 Dec 2011 16:31:37 +0100 5515915 Non-selective β-blockers improve the correlation of liver stiffness and portal pressure in advanced cirrhosis http://www.medworm.com/index.php?rid=5515917&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn78587h21307n44l%2F Conclusions  Targeting the hyperdynamic circulation and the increased splanchnic blood inflow by treatment with NSBB unmasks the linear (mechanical) correlation of HVPG and LS in patients with HVPG > 12 mmHg. Measurement of LS by TE is not a feasible method to assess the dynamic components of PHT. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-8DOI 10.1007/s00535-011-0517-4Authors T. Reiberger, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University Vienna, Waehringer Guertel 18-20, Vienna, AustriaA. Ferlitsch, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University Vienna, Waehringer Guertel 18-20, Vienna, Aus... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5515917 Wed, 14 Dec 2011 16:31:36 +0100 5515917 Endogenous orexin-A in the brain mediates 2-deoxy-d-glucose-induced stimulation of gastric motility in freely moving conscious rats http://www.medworm.com/index.php?rid=5515920&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvj361k472540648w%2F Conclusions  These results suggest that endogenous orexin-A in the brain is involved in the vagal-dependent stimulation of gastric contractions. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-8DOI 10.1007/s00535-011-0506-7Authors Tsukasa Nozu, Department of Regional Medicine and Education, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, 078-8510 JapanYoshihiro Tuchiya, Department of General Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, 078-8510 JapanShima Kumei, Department of General Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka Higashi, Asahikawa, 078-8510 JapanKaoru Takakusaki, Research Center for Brain Function and Medical Engineering, Asahikawa Medical University, 2... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5515920 Wed, 14 Dec 2011 16:31:33 +0100 5515920 Erratum to: Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma http://www.medworm.com/index.php?rid=5515919&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F53u8n758255hl7v7%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s00535-011-0508-5Authors Hideaki Kinugasa, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 JapanKazuhiro Nouso, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 JapanYasuto Takeuchi, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 JapanTetsuya Yasunaka, Department of Gastroenterology and Hepatology, Okayama University Graduate Scho... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5515919 Wed, 14 Dec 2011 16:31:33 +0100 5515919 Targeting the hedgehog signaling pathway with interacting peptides to Patched-1 http://www.medworm.com/index.php?rid=5515918&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd7173230330117l8%2F Conclusions  This study suggests that interacting peptides to Ptch1 may be a new tool for controlling the Hh-dependent growth of pancreatic cancer. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-9DOI 10.1007/s00535-011-0507-6Authors Masafumi Nakamura, Department of Digestive Surgery, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192 JapanHaruo Tanaka, Department of Surgery and Oncology, Graduate School of Medicine, Kyushu University, Fukuoka, JapanYousuke Nagayoshi, Department of Surgery and Oncology, Graduate School of Medicine, Kyushu University, Fukuoka, JapanHiroshi Nakashima, Department of Digestive Surgery, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192 JapanKosuke Tsutsumi, Department o... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5515918 Wed, 14 Dec 2011 16:31:33 +0100 5515918 Ten-year prospective follow-up of histological changes at five points on the gastric mucosa as recommended by the updated Sydney system after Helicobacter pylori eradication http://www.medworm.com/index.php?rid=5487760&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvh8k978w55727p72%2F Conclusion  In 10 years after H. pylori eradication, atrophy at all sites and IM in the lesser curvature of the corpus gradually and significantly decreased. These results suggest that the improvement of gastric atrophy and IM might have association with the reduction of gastric cancer occurrence. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-10DOI 10.1007/s00535-011-0504-9Authors Masaaki Kodama, Department of Gastroenterology, Faculty of Medicine, Oita University, Hasama-machi, Oita, 879-5593 JapanKazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, Hasama-machi, Oita, 879-5593 JapanTadayoshi Okimoto, Department of Gastroenterology, Faculty of Medicine, Oita University, Hasama-machi, Oita, 87... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5487760 Mon, 05 Dec 2011 06:33:09 +0100 5487760 Loss of autophagy promotes murine acetaminophen hepatotoxicity http://www.medworm.com/index.php?rid=5458697&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp5x863176297636l%2F Conclusions  Induction of autophagy during acetaminophen treatment plays a pivotal role in the protection against acetaminophen-induced hepatotoxicity through the removal of damaged mitochondria and oxidative stress. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-11DOI 10.1007/s00535-011-0500-0Authors Yuki Igusa, Department of Gastroenterology, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421 JapanShunhei Yamashina, Department of Gastroenterology, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421 JapanKousuke Izumi, Department of Gastroenterology, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo, 113-8421 JapanYoshihiro Inami, Department... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5458697 Mon, 28 Nov 2011 16:49:51 +0100 5458697 Reducing Peg-IFN doses causes later virologic response or no response in HCV genotype 1 patients treated with Peg-IFN alfa-2b plus ribavirin http://www.medworm.com/index.php?rid=5449998&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Frq937l3n352g6xpw%2F Conclusions  The timing of HCV RNA negativity depends significantly on the Peg-IFN dose. Reducing the Peg-IFN dose can induce a later virologic response or non-response in HCV genotype 1 patients treated with Peg-IFN plus ribavirin. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-9DOI 10.1007/s00535-011-0498-3Authors Tsugiko Oze, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, JapanNaoki Hiramatsu, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, JapanChangho Song, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5449998 Tue, 22 Nov 2011 17:56:38 +0100 5449998 Decrease in alpha-fetoprotein levels predicts reduced incidence of hepatocellular carcinoma in patients with hepatitis C virus infection receiving interferon therapy: a single center study http://www.medworm.com/index.php?rid=5449999&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fth052p7561020326%2F Conclusions  Achieving sustained virological response (SVR) by interferon therapy reduces the incidence of HCC in hepatitis C patients treated with interferon. Among non-SVR patients, a decrease in the AFP integration value by interferon therapy closely correlates with reduced risk of HCC incidence after treatment. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-8DOI 10.1007/s00535-011-0505-8Authors Yukio Osaki, Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-53 Fudegasaki-cho, Tennoji-ku, Osaka, 543-8555 JapanYoshihide Ueda, Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507 JapanHiroyuki Marusawa... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5449999 Tue, 22 Nov 2011 06:57:48 +0100 5449999 Leukocytapheresis for steroid-dependent ulcerative colitis in clinical practice: results of a nationwide Spanish registry http://www.medworm.com/index.php?rid=5450000&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa2qg182014p57417%2F Conclusions  In clinical practice, apheresis allows long-term steroid-free clinical remission in up to one third of steroid-dependent UC patients, even in those with prior failure of thiopurines. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-7DOI 10.1007/s00535-011-0499-2Authors J. L. Cabriada, Hospital Galdakao-Usansolo, Galdakao, Vizcaya, SpainE. Domènech, IBD Unit, Gastroenterology and Hepatology Department, Hospital Universitari Germans Trias i Pujol, 5th floor, edifici general, Ctra. del Canyet s/n, 08916 Badalona, Catalonia, SpainN. Ibargoyen, Basque Office for Health Technology Assessment-Osteba, Vitoria, SpainV. Hernández, Complexo Hospitalario Universitario, Vigo, SpainJ. Clofent, Hospital Manises, Valencia, SpainD. Ginard,... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5450000 Tue, 22 Nov 2011 06:57:46 +0100 5450000 Debate continues over which method we should prefer for the preoperative biliary decompression in cases with hilar cholangiocarcinoma http://www.medworm.com/index.php?rid=5409370&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb788564287vq37q2%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00535-011-0496-5Authors Yücel Üstündağ, Zonguldak Karaelmas University School of Medicine, 67600 Kozlu, Zonguldak, TurkeyFatih Boyvat, Department of Radiology, Baskent University School of Medicine, Ankara, Turkey Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 (Source: Journal of Gastroenterology) Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5409370 Mon, 14 Nov 2011 06:35:29 +0100 5409370 Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan http://www.medworm.com/index.php?rid=5409369&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk131184144738302%2F Conclusion  Rikkunshito combined with standard-dose RPZ therapy may be a useful new strategy for PPI-refractory GERD patients. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-9DOI 10.1007/s00535-011-0488-5Authors Kazunari Tominaga, Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-ku, Osaka, JapanRyuichi Iwakiri, Department of Internal Medicine, Saga Medical School, Saga, JapanKazuma Fujimoto, Department of Internal Medicine, Saga Medical School, Saga, JapanYasuhiro Fujiwara, Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-ku, Osaka, JapanMio Tanaka, Department of Internal Medicine, Saga Medical School, Saga, JapanYasuyuki ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5409369 Mon, 14 Nov 2011 06:35:29 +0100 5409369 A mechanism for abnormal angiogenesis in human radiation proctitis: analysis of expression profile for angiogenic factors http://www.medworm.com/index.php?rid=5409368&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk57214w54tn64226%2F Conclusions  Our results suggest that in radiation proctitis, MMP-8 and uPA cooperatively degrade the extracellular matrix and basement membrane to provide space for angiogenesis. Simultaneously, angiogenin and FGF1 promote endothelial cell proliferation, and endoglin induces vessel formation, culminating in angiogenesis. Inhibitors of angiogenic factors such as angiogenin and FGF1 may be effective for treating radiation proctitis. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-9DOI 10.1007/s00535-011-0470-2Authors Hisashi Takeuchi, Department of Gastroenterology and Oncology, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima, 770-8503 JapanTetsuo Kimura, Department of Gastroent... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5409368 Mon, 14 Nov 2011 06:35:29 +0100 5409368 The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons http://www.medworm.com/index.php?rid=5409371&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6h87k776737720m5%2F Conclusions  The spatial correlation among increased colonic innervation density, TRPV1 receptor expression, stimulated SP release, and colitis severity suggested that TRPV1/SP-expressing sensory neurons should be considered as a therapeutic target in human ulcerative colitis. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-10DOI 10.1007/s00535-011-0495-6Authors Matthias A. Engel, Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 17, 91054 Erlangen, GermanyMohammad Khalil, Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstr. 17, 91054 Erlangen, GermanySonja M. Mueller-Tribbensee, Institute of Physiology and P... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5409371 Fri, 11 Nov 2011 12:48:39 +0100 5409371 Reply to the letter by Yucel Üstündağ et al. regarding “Endoscopic nasobiliary drainage is most suitable for preoperative management in patients with hilar cholangiocarcinoma” http://www.medworm.com/index.php?rid=5409372&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd776011v55327825%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00535-011-0497-4Authors Hiroshi Kawakami, Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638 JapanMasaki Kuwatani, Department of Gastroenterology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638 JapanEiichi Tanaka, Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, JapanSatoshi Hirano, Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 (Source: Journal of Gastroenterology) Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5409372 Fri, 11 Nov 2011 12:48:38 +0100 5409372 Preclinical study of the DNA repair inhibitor Dbait in combination with chemotherapy in colorectal cancer http://www.medworm.com/index.php?rid=5409373&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq475p1188750j319%2F Conclusions  The use of Dbait to inhibit DNA repair may be an effective additional treatment for increasing the efficacy of chemotherapy in colon or rectal cancer, independently of KRAS status. Content Type Journal ArticleCategory Original Article-Alimentary TractPages 1-10DOI 10.1007/s00535-011-0483-xAuthors Flavien Devun, Institut Curie, Equipe Dutreix, Bat 110, Research Centre, Centre Universitaire, 91405 Paris-Orsay, FranceGuilhem Bousquet, Institut Curie, Equipe Dutreix, Bat 110, Research Centre, Centre Universitaire, 91405 Paris-Orsay, FranceJulian Biau, Institut Curie, Equipe Dutreix, Bat 110, Research Centre, Centre Universitaire, 91405 Paris-Orsay, FranceAurélie Herbette, DNA Therapeutics, SA, Pépinière Genopole Entreprises, 4 rue Pierre Fontaine, 91058 Ev... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5409373 Tue, 08 Nov 2011 16:48:43 +0100 5409373 A large-scale nationwide multicenter prospective observational study of triple therapy using rabeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in Japan http://www.medworm.com/index.php?rid=5409375&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F255147306u060467%2F Conclusion  In a large-scale nationwide study of use in clinical practice, RAC therapy was confirmed to be effective and safe. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-8DOI 10.1007/s00535-011-0487-6Authors Toshio Fujioka, Department of Gastroenterology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita 879-5593, JapanNobuo Aoyama, GI Endoscopy and IBD Center, Aoyama Clinic, Kobe, JapanKyoko Sakai, Center for Digestive and Liver Diseases, Nara City Hospital, Nara, JapanYoshiyuki Miwa, Miwa Clinic, Gifu, JapanMineo Kudo, Department of Gastroenterology, Sapporo Hokuyu Hospital, Sapporo, JapanJunichi Kawashima, Department of Gastroenterology and Hepatology, Saitama Medical Center, Saitama Medical University, ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5409375 Tue, 08 Nov 2011 06:48:06 +0100 5409375 Splenectomy enhances the anti-fibrotic effect of bone marrow cell infusion and improves liver function in cirrhotic mice and patients http://www.medworm.com/index.php?rid=5409374&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa0rr6456p4377504%2F Conclusion  ABMi therapy with splenectomy may be an effective therapeutic modality for cirrhosis. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-13DOI 10.1007/s00535-011-0486-7Authors Takuya Iwamoto, Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1-1-1, Ube, Yamaguchi 755-8505, JapanShuji Terai, Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1-1-1, Ube, Yamaguchi 755-8505, JapanYuko Mizunaga, Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1-1-1, Ube, Yamaguchi 755-8505, JapanNaoki Yamamoto, Department of Gastroenterology and He... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5409374 Tue, 08 Nov 2011 06:48:06 +0100 5409374 Usefulness of differentiating metabolic syndrome into visceral fat type and subcutaneous fat type using ultrasonography in Japanese males http://www.medworm.com/index.php?rid=5409377&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F18836803g7083lr7%2F Conclusions  Japanese males with visceral fat type MS are more likely to have dyslipidemia, fatty liver, and liver dysfunction than those with subcutaneous fat type MS. Visceral fat type MS is one of the most significant risk factors for NAFLD in Japanese males with MS. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-7DOI 10.1007/s00535-011-0489-4Authors Masahiro Sogabe, Department of Gastroenterology, Kagawa Prefectural Cancer Detection Center, 587-1 Goto-cho, Takamatsu, Kagawa 761-8031, JapanToshiya Okahisa, Department of Gastroenterology and Oncology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, JapanShingo Hibino, Department of Internal Medicine, Hibino Hospital, Tokushi... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5409377 Tue, 08 Nov 2011 06:48:04 +0100 5409377 Acoustic radiation force impulse elastography for noninvasive assessment of chronic pancreatitis http://www.medworm.com/index.php?rid=5409376&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9643x84k38042561%2F Conclusions  ARFI elastography of the pancreas showed high elasticity in chronic pancreatitis compared to findings in the normal pancreas. This modality is feasible to use for the diagnosis of chronic pancreatitis. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-6DOI 10.1007/s00535-011-0491-xAuthors Yoko Yashima, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanNaoki Sasahira, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanHiroyuki Isayama, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5409376 Tue, 08 Nov 2011 06:48:04 +0100 5409376 Pancreatic cancer stem cell biology and its therapeutic implications http://www.medworm.com/index.php?rid=5388435&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F721765316t7m5712%2F Abstract  Pancreatic cancer remains one of the most difficult malignancies to treat. Significant developments in our understanding of pancreatic cancer biology have occurred over the past decade. One of the key advances has been the formulation of the cancer stem cell model of tumor growth and subsequent experimental proof of pancreatic cancer stem cell existence. Cancer stem cells contribute to pancreatic tumor growth and progression and are at least partially responsible for the relative resistance of the tumor to systemic chemotherapy and radiation. Significant questions remain about how the mutational profile of the tumor, the tumor microenvironment, and normal pancreatic developmental pathways contribute to pancreatic cancer stem cell biology. Answers to these question... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5388435 Wed, 02 Nov 2011 16:58:43 +0100 5388435 Current status of primary malignant melanoma of the esophagus: clinical features, pathology, management and prognosis http://www.medworm.com/index.php?rid=5388434&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff01741w79q515308%2F Abstract  Primary malignant melanoma of the esophagus (PMME) is a rare disease with an extremely poor prognosis. Up to 2011, approximately 300 cases had been reported worldwide. The average age of onset is 60.5 years old, with a prevalence of males (2:1). A typical finding of PMME is a lobular or polyploid, well-circumscribed and pigmented tumor, partly covered with normal mucosa. PMME represents various colors depending on its melanin quantity and commonly coexists with intramural metastases, melanocytosis or melanoma in situ. The tumor is located from the middle to lower thoracic esophagus. The accuracy of diagnosis from biopsy is approximately 80%, because many cases are misdiagnosed as a poorly differentiated carcinoma because of the absence of melanin granules. A ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5388434 Wed, 02 Nov 2011 16:58:43 +0100 5388434 Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma http://www.medworm.com/index.php?rid=5388436&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F684u8g101536x6p4%2F Conclusions  Heterogeneous Lipiodol uptake, high serum DCP, and multiple tumors are risk factors for recurrence in patients with early-stage HCC who have undergone palliative TACE. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-6DOI 10.1007/s00535-011-0492-9Authors Hideaki Kinugasa, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 JapanKazuhiro Nouso, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 JapanYasuto Takeuchi, Department of Gastroenterology and Hep... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5388436 Wed, 02 Nov 2011 16:58:42 +0100 5388436 Diagnosis of gastroenterological diseases by metabolome analysis using gas chromatography–mass spectrometry http://www.medworm.com/index.php?rid=5388437&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4435473538u20623%2F Abstract  Recently, metabolome analysis has been increasingly applied to biomarker detection and disease diagnosis in medical studies. Metabolome analysis is a strategy for studying the characteristics and interactions of low molecular weight metabolites under a specific set of conditions and is performed using mass spectrometry and nuclear magnetic resonance spectroscopy. There is a strong possibility that changes in metabolite levels reflect the functional status of a cell because alterations in their levels occur downstream of DNA, RNA, and protein. Therefore, the metabolite profile of a cell is more likely to represent the current status of a cell than DNA, RNA, or protein. Thus, owing to the rapid development of mass spectrometry analytical techniques metabolome analys... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5388437 Tue, 01 Nov 2011 05:54:58 +0100 5388437 Glycogen synthase kinase 3β inhibition sensitizes pancreatic cancer cells to gemcitabine http://www.medworm.com/index.php?rid=5388438&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F652818743336614g%2F Conclusions  The results indicate that GSK3β inhibition sensitizes pancreatic cancer cells to gemcitabine with altered expression of genes involved in DNA repair. This study provides insight into the molecular mechanism of gemcitabine resistance and thus a new strategy for pancreatic cancer chemotherapy. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-13DOI 10.1007/s00535-011-0484-9Authors Takeo Shimasaki, Department of Medical Oncology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293 JapanYasuhito Ishigaki, Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293 JapanYuka Nakamura, Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5388438 Mon, 31 Oct 2011 16:50:40 +0100 5388438 Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression http://www.medworm.com/index.php?rid=5388439&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw85p1l73382j550h%2F Conclusions  There may be distinct mechanisms of pancreatic cancer progression in the different subtypes of IPMN. In particular, KRAS mutation and bone morphogenetic protein-SMAD signaling status may be crucial diverging steps for the two representative pathways to pancreatic cancer in IPMN patients. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-11DOI 10.1007/s00535-011-0482-yAuthors Dai Mohri, Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanYoshinari Asaoka, Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanHideaki Ijichi, Department of Gastroenterology, Graduate... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5388439 Mon, 31 Oct 2011 16:50:39 +0100 5388439 Combination of angiotensin II receptor blockers promotes proton pump inhibitor-based healing of reflux esophagitis http://www.medworm.com/index.php?rid=5388440&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5t6g21u8t1t84433%2F Conclusions  Concomitant use of ARBs may promote endoscopic healing of RE treated with PPIs. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-7DOI 10.1007/s00535-011-0479-6Authors Hiroto Miwa, Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, JapanMichio Hongo, Department of Comprehensive Medicine and Psychosomatic Medicine, Tohoku University Hospital, Sendai, JapanMotoyasu Kusano, Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Maebashi, JapanThe J-FAST Group Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 (Source: Journal of Gastroenterology) Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5388440 Mon, 31 Oct 2011 16:50:37 +0100 5388440 The efficacy and safety of terlipressin and albumin in patients with type 1 hepatorenal syndrome: a multicenter, open-label, explorative study http://www.medworm.com/index.php?rid=5362378&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl212802w6822m122%2F Conclusions  Treatment with terlipressin and albumin improves renal function in cirrhotic patients with type 1 HRS. However, the survival of cirrhotic patients with type 1 HRS remains poor, although it may be improved by this specific therapy. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-8DOI 10.1007/s00535-011-0485-8Authors Yoshiyuki Narahara, Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603 JapanHidenori Kanazawa, Division of Gastroenterology, Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603 JapanChoitsu Sakamoto, Division of Gastroenterology, Department of Internal Medicine, Nippon Medic... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5362378 Fri, 28 Oct 2011 17:17:53 +0100 5362378 Impedance-pH reflux patterns can differentiate non-erosive reflux disease from functional heartburn patients http://www.medworm.com/index.php?rid=5362377&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl53583r7gu743413%2F Conclusion  In patients with normal AET and SAP+, increased number of weakly acidic reflux and higher rate of proximal reflux are the main discriminant features. There is large overlap between FH and HVs. These differences can be of help in diagnosing patients with normal oesophageal acid exposure who fail to have symptoms during MII-pH testing. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-10DOI 10.1007/s00535-011-0480-0Authors Edoardo Savarino, Division of Gastroenterology, Department of Internal Medicine, University of Genoa, Genoa, ItalyPatrizia Zentilin, Division of Gastroenterology, Department of Internal Medicine, University of Genoa, Genoa, ItalyRadu Tutuian, Division of Gastroenterology and Hepatology, Department of Internal... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5362377 Fri, 28 Oct 2011 17:17:53 +0100 5362377 Association of gastric acid and mucus secretion level with low-dose aspirin-induced gastropathy http://www.medworm.com/index.php?rid=5362379&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4l258g8114348248%2F Conclusion  Overall, gastric mucus secretion is increased in aspirin-takers, suggesting a functional adaptive response to long-term administration of the drug. However, it is possible that the adaptive response is impaired in some aspirin takers, who might be susceptible to severe upper gastrointestinal complication. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-9DOI 10.1007/s00535-011-0478-7Authors Katsunori Iijima, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aobaku, Sendai, Miyagi 980-8574, JapanNobuyuki Ara, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aobaku, Sendai, Miyagi 980-8574, JapanYasuhiko Abe, Division of Gastroenterology... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5362379 Fri, 28 Oct 2011 17:17:51 +0100 5362379 Geranylgeranylacetone has anti-hepatitis C virus activity via activation of mTOR in human hepatoma cells http://www.medworm.com/index.php?rid=5362380&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft2063658442226k8%2F Conclusions  GGA has mTOR dependent anti-HCV activity. There is a possibility that the GGA anti-HCV activity can be complimented by IFN. It will be necessary to examine the clinical effectiveness of the combination of GGA and IFN for HCV patients in the future. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-8DOI 10.1007/s00535-011-0481-zAuthors Shigeyuki Takeshita, Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8501 JapanTatsuki Ichikawa, Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8501 JapanNaota Taura, Department of Gastroenterology a... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5362380 Fri, 28 Oct 2011 17:17:49 +0100 5362380 Lowered expression of galectin-2 is associated with lymph node metastasis in gastric cancer http://www.medworm.com/index.php?rid=5348702&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd31650x5w73t666j%2F Conclusion  Our results show that proteomic analysis coupled with immunohistochemistry using tissue microarray is a useful tool for identifying LNM-associated proteins in GC. Also, loss of galectin-2 might play an important role in the aggressiveness of GC. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-12DOI 10.1007/s00535-011-0463-1Authors Ji-Han Jung, BRI, Korea Institute of Science and Technology, 39-1 Hawolgok, Seongbuk, Seoul, 136-791 KoreaHye-Jung Kim, BRI, Korea Institute of Science and Technology, 39-1 Hawolgok, Seongbuk, Seoul, 136-791 KoreaJeonghun Yeom, BRI, Korea Institute of Science and Technology, 39-1 Hawolgok, Seongbuk, Seoul, 136-791 KoreaChangyoung Yoo, Department of Hospital Pathology, St. Vincent Hospital, College ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5348702 Fri, 21 Oct 2011 06:11:51 +0100 5348702 Detectability of colorectal neoplasia with fluorine-18-2-fluoro-2-deoxy-d-glucose positron emission tomography and computed tomography (FDG-PET/CT) http://www.medworm.com/index.php?rid=5305103&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv186732m46h248u5%2F Conclusion  The sensitivity of PET/CT for detecting colorectal lesions is acceptable, showing size- and pathology-dependence, suggesting, for the most part, that clinically relevant lesions are detectable with PET/CT. However, when considering PET/CT for screening purposes caution must be exercised because there are cases of false-negative results. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-9DOI 10.1007/s00535-011-0473-zAuthors Tomoko Hirakawa, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558 JapanJun Kato, Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5305103 Fri, 07 Oct 2011 15:58:28 +0100 5305103 Treatment of nonalcoholic fatty liver disease in adults and children: a closer look at the arsenal http://www.medworm.com/index.php?rid=5305102&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F58k4831543254tm3%2F Abstract  Nonalcoholic fatty liver disease encompasses a spectrum of disease from asymptomatic steatosis, with or without elevated aminotransferases, to cirrhosis with relative complications and hepatocellular carcinoma. Owing to the increasing prevalence of nonalcoholic fatty liver disease and the potential for nonalcoholic steatohepatitis to progress to cirrhosis and liver-related mortality, more research has been focused on therapy of this important liver disease over the last two decades. To date, weight loss and physical activity represent the cornerstone of treatment, with interventions being limited to subjects at risk of disease progression, but the type of treatment remains a matter of debate. A few medications have shown promising results in preliminary pilot stud... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5305102 Fri, 07 Oct 2011 15:58:28 +0100 5305102 Comparisons of symptoms reported by elderly and non-elderly patients with GERD http://www.medworm.com/index.php?rid=5305104&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F48476421m88473xg%2F Conclusion  Elderly patients with GERD tend to show typical GERD symptoms frequently at the typical post-prandial time points in a day, irrespective of the presence of esophageal mucosal breaks. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-6DOI 10.1007/s00535-011-0476-9Authors Kenji Furuta, Second Department of Internal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo, Shimane 693-8501, JapanYoshinori Kushiyama, Department of Gastroenterology, Matsue Red Cross Hospital, Matsue, JapanKousaku Kawashima, Department of Internal Medicine, Matsue Coop Hospital, Matsue, JapanKotaro Shibagaki, Department of Internal Medicine, Tottori Municipal Hospital, Tottori, JapanYoshinori Komazawa, Division of Internal Medicine, I... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5305104 Fri, 07 Oct 2011 15:58:25 +0100 5305104 Usefulness of miriplatin as an anticancer agent for transcatheter arterial chemoembolization in patients with unresectable hepatocellular carcinoma http://www.medworm.com/index.php?rid=5305105&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F610j54147r15022l%2F Conclusions  Miriplatin is a useful and safe agent for TACE in patients with HCC stage I or II and/or JIS score 0 or 1 only when radiofrequency ablation and liver resection cannot be performed. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-8DOI 10.1007/s00535-011-0475-xAuthors Yukinori Imai, Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama-cho, Iruma-gun, Saitama 350-0495, JapanTaku Chikayama, Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama-cho, Iruma-gun, Saitama 350-0495, JapanManabu Nakazawa, Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5305105 Thu, 06 Oct 2011 05:48:38 +0100 5305105 Serum gamma-glutamyltransferase level is associated with serum superoxide dismutase activity and metabolic syndrome in a Japanese population http://www.medworm.com/index.php?rid=5305106&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd21j010511293655%2F Conclusions  The serum gamma-glutamyltransferase level, even in the normal range, was significantly associated with anti-oxidative stress activity, the accumulation of oxidative stress, metabolic syndrome, and atherosclerosis. Measuring the serum gamma-glutamyltransferase level is simple and inexpensive, and this level can be used as a sensitive marker of oxidative stress and metabolic syndrome. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-8DOI 10.1007/s00535-011-0477-8Authors Hayato Nakagawa, Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanAkihiro Isogawa, Department of Internal Medicine, Mitsui Memorial Hospital, 1 Kanda-Izumi-cho, Chiyoda-ku, Tokyo, 101-8643 Japa... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5305106 Thu, 06 Oct 2011 05:48:36 +0100 5305106 Development of a new immunoassay for the accurate determination of anti-infliximab antibodies in inflammatory bowel disease http://www.medworm.com/index.php?rid=5274658&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg400w73821868157%2F Conclusions  The new method makes it possible to measure serum ATI levels in the presence of infliximab. This method is useful for deciding the optimal management strategies for IBD patients with loss of response to infliximab. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-8DOI 10.1007/s00535-011-0474-yAuthors Hirotsugu Imaeda, Department of Medicine, Shiga University of Medical Science, Seta-Tukinowa, Otsu, 520-2192 JapanAkira Andoh, Division of Mucosal Immunology, Graduate School, Shiga University of Medical Science, Seta-Tukinowa, Otsu, 520-2192 JapanYoshihide Fujiyama, Department of Medicine, Shiga University of Medical Science, Seta-Tukinowa, Otsu, 520-2192 Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Prin... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5274658 Wed, 28 Sep 2011 05:48:40 +0100 5274658 Differential effects of nutritional and non-nutritional therapies on intestinal barrier function in an in vitro model http://www.medworm.com/index.php?rid=5274659&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp49040085qljq647%2F Conclusions  Both polymeric formula and infliximab completely prevent epithelial barrier dysfunction in the presence of TNF-α, whereas hydrocortisone partially prevents barrier dysfunction. These results provide evidence that superior mucosal healing can be achieved with both polymeric formula and infliximab compared to hydrocortisone. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-11DOI 10.1007/s00535-011-0471-1Authors Lily Nahidi, School of Women’s and Children’s Health, University of New South Wales, Randwick, Sydney, NSW, AustraliaAndrew S. Day, School of Women’s and Children’s Health, University of New South Wales, Randwick, Sydney, NSW, AustraliaDaniel A. Lemberg, Department of Gastroenterology, Sydney Children’s Hosp... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5274659 Wed, 28 Sep 2011 05:48:38 +0100 5274659 Dynamics of regulatory T cells and plasmacytoid dendritic cells as immune markers for virological response in pegylated interferon-α and ribavirin therapy for chronic hepatitis C patients http://www.medworm.com/index.php?rid=5274661&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh884315121722341%2F Conclusions  In PEG-IFNα and ribavirin combination therapy for chronic hepatitis C patients, the increments of regulatory T cells and plasmacytoid dendritic cell frequency are independently related to favorable virological response to the therapy. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-10DOI 10.1007/s00535-011-0466-yAuthors Tatsuya Kanto, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, JapanMichiyo Inoue, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, JapanTsugiko Oze, Department of Gastroenterology and Hepatology, Osaka University Graduate Sc... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5274661 Tue, 27 Sep 2011 05:43:13 +0100 5274661 Long-term administration of PPI reduces treatment failures after esophageal variceal band ligation: a randomized, controlled trial http://www.medworm.com/index.php?rid=5274660&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr45183n5048104h5%2F Conclusions  Long-term administration of PPIs reduced the risk of treatment failure after EVL. Acid suppression therapy should also be considered as a treatment option after EVL. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-9DOI 10.1007/s00535-011-0472-0Authors Hisashi Hidaka, Department of Gastroenterology, Internal Medicine, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, JapanTakahide Nakazawa, Department of Gastroenterology, Internal Medicine, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, JapanGuoqin Wang, Kitasato Clinical Research Center, Kitasato University School of Medicine, Sagamihara, JapanShigehiro Kokubu, Department of Gastroe... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5274660 Tue, 27 Sep 2011 05:43:13 +0100 5274660 Reply to the letter by A. Eshraghian et al. regarding “Oral steroid versus steroid pulse therapy for autoimmune pancreatitis” http://www.medworm.com/index.php?rid=5261560&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh135204563169411%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00535-011-0469-8Authors Kazushige Uchida, The Third Department of Internal Medicine, Kansai Medical University, Moriguchi, JapanTakashi Tomiyama, The Third Department of Internal Medicine, Kansai Medical University, Moriguchi, JapanMitsunobu Matsushita, The Third Department of Internal Medicine, Kansai Medical University, Moriguchi, JapanKazuichi Okazaki, The Third Department of Internal Medicine, Kansai Medical University, Moriguchi, Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 (Source: Journal of Gastroenterology) Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5261560 Sat, 24 Sep 2011 05:42:12 +0100 5261560 Diagnostic criteria for IgG4-related sclerosing cholangitis based on cholangiographic classification http://www.medworm.com/index.php?rid=5251406&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr1494717477k6264%2F Conclusions  Diagnostic criteria for IgG4-SC based on cholangiographic classification are useful for distinguishing it from PCa, PSC, and CC. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-9DOI 10.1007/s00535-011-0465-zAuthors Takahiro Nakazawa, Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601 JapanItaru Naitoh, Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601 JapanKazuki Hayashi, Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizu... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5251406 Fri, 23 Sep 2011 05:46:18 +0100 5251406 Is cholecystectomy necessary after endoscopic treatment of bile duct stones in patients older than 80 years of age? http://www.medworm.com/index.php?rid=5251407&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa3107276n2072p64%2F Conclusions  In very elderly patients the incidence of acute cholecystitis is low even when the gallbladder is preserved after endoscopic treatment of CBDS, with a similar risk of CBDS recurrence. Thus, it may not be necessary to recommend cholecystectomy after ES for CBDS in very elderly patients. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-6DOI 10.1007/s00535-011-0461-3Authors Takaharu Yasui, Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582 JapanShunichi Takahata, Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582 JapanHiroshi Kono, Department of Surgery and Onco... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5251407 Wed, 21 Sep 2011 16:25:01 +0100 5251407 Evaluation of molecular targeted cancer drug by changes in tumor marker doubling times http://www.medworm.com/index.php?rid=5251408&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F15091p753174714w%2F Conclusions  Serum tumor marker DT can be used to evaluate viable tumor burden irrespective of the presence of tumor necrosis which can compromise radiographic evaluation. This approach may be applicable to the evaluation of responses to chemotherapy, particularly to cytostatic agents (ClinicalTrials.gov number, NCT00784290). Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-8DOI 10.1007/s00535-011-0462-2Authors Kenichiro Enooku, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanRyosuke Tateishi, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanFumihiko Kanai,... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5251408 Tue, 20 Sep 2011 15:46:53 +0100 5251408 Oral steroid versus steroid pulse therapy for autoimmune pancreatitis: time to introduce new weapons http://www.medworm.com/index.php?rid=5251409&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1g625t1424576817%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00535-011-0468-9Authors Ahad Eshraghian, Internal Medicine Department, Namazi Hospital, Shiraz University of Medical Science, P.O. Box 71345-1744, Shiraz, IranHamed Eshraghian, Internal Medicine Department, Namazi Hospital, Shiraz University of Medical Science, P.O. Box 71345-1744, Shiraz, Iran Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 (Source: Journal of Gastroenterology) Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5251409 Tue, 20 Sep 2011 05:50:11 +0100 5251409 Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells http://www.medworm.com/index.php?rid=5226989&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F10m7965p2v1u65w7%2F Conclusion  The PIR-A/Bmed cDCs, which increase in number during the final stages of inflammation, can be used to treat colitis via an IDO-dependent mechanism. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-14DOI 10.1007/s00535-011-0460-4Authors Shoichi Hoshino, The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Moriguchi, Osaka, JapanAkiko Kurishima, The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Moriguchi, Osaka, JapanMuneo Inaba, First Department of Pathology, Kansai Medical University, Moriguchi, Osaka, JapanYugo Ando, The Third Department of Internal Medicine, Division of Gastroenterology and Hepatolo... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5226989 Thu, 15 Sep 2011 15:49:34 +0100 5226989 Quantitative analysis of colorectal lesions observed on magnified endoscopy images http://www.medworm.com/index.php?rid=5226990&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F72gjw45737314313%2F Conclusions  Computer analysis of magnified endoscopy images for the diagnosis of colorectal lesions appears feasible. We anticipate further developments in the computer-aided diagnosis of pit patterns on magnified endoscopy images. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-9DOI 10.1007/s00535-011-0459-xAuthors Keiichi Onji, Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551 JapanShigeto Yoshida, Department of Endoscopy, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551 JapanShinji Tanaka, Department of Endoscopy, Hiroshima University Hospital, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551 JapanRie Kawase,... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5226990 Thu, 15 Sep 2011 05:49:54 +0100 5226990 Processed blood volume impacts clinical efficacy in patients with ulcerative colitis undergoing adsorptive depletion of myeloid lineage leucocytes http://www.medworm.com/index.php?rid=5226991&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk42384733574q87n%2F Conclusions  GMA adjusted to patients’ BW and at a vastly greater processed volume produces significantly higher efficacy as compared with the routine GMA protocol. Further, in this study, up to twofold higher processed volume caused no safety concern. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-7DOI 10.1007/s00535-011-0464-0Authors Naoki Yoshimura, Department of Internal Medicine, Social Insurance Central General Hospital, 3-22-1 Hyakunin cho, Shinjuku-ku, Tokyo, 169-0073 JapanTokuma Tadami, Department of Internal Medicine, Social Insurance Central General Hospital, 3-22-1 Hyakunin cho, Shinjuku-ku, Tokyo, 169-0073 JapanTakaaki Kawaguchi, Department of Internal Medicine, Social Insurance Central General Hospital, 3-22-1 Hyakunin ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5226991 Tue, 13 Sep 2011 15:44:43 +0100 5226991 The determination of GGT is the most reliable predictor of nonresponsiveness to interferon-alpha based therapy in HCV type-1 infection http://www.medworm.com/index.php?rid=5226992&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2519k74q541016nl%2F Conclusions  These findings prove the predictive sensitivity of GGT as an independent indicator of nonresponsiveness even at levels that are slightly above the normal range. This new predictive parameter may help to improve individualized therapy in HCV type-1 infection. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-10DOI 10.1007/s00535-011-0458-yAuthors Viola Weich, Universitätsklinikum Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin, GermanyEva Herrmann, Institut für Biostatistik und mathematische Modellierung, Goethe-Universität Frankfurt, Frankfurt, GermanyTje Lin Chung, Institut für Biostatistik und mathematische Modellierung, Goethe-Universität Frankfurt, Frankfurt, GermanyChristoph... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5226992 Mon, 12 Sep 2011 15:52:37 +0100 5226992 Lifestyle and psychological factors related to irritable bowel syndrome in nursing and medical school students http://www.medworm.com/index.php?rid=5163102&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3676546278573jm5%2F Conclusions  The prevalence of IBS was higher among nursing and medical students, and further interventional studies are needed to improve IBS symptoms. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-8DOI 10.1007/s00535-011-0454-2Authors Yukiko Okami, Department of Health and Nutrition, Nagoya Bunri University, Nagoya, JapanTakako Kato, Watanabe Clinic, Tokyo, JapanGyozen Nin, Ex-Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, JapanKiyomi Harada, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5 Hangi-cho, Shimogamo, Sakyo-ku, Kyoto, 606-8522 JapanWataru Aoi, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5 Hangi-cho, Shimo... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5163102 Tue, 23 Aug 2011 15:50:23 +0100 5163102 Differential expression of miR-144* as a novel fecal-based diagnostic marker for colorectal cancer http://www.medworm.com/index.php?rid=5163103&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft48164l224521362%2F Conclusions  We demonstrated that miRNAs are stable in the fecal microenvironment, and that, among them, miR-144* represents a novel fecal-based diagnostic marker for CRC screening. Nevertheless, our data need to be validated in a large cohort of subjects. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-12DOI 10.1007/s00535-011-0456-0Authors Murugan Kalimutho, Department of Internal Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyGiovanna Del Vecchio Blanco, Gastroenterology Unit, University Hospital Tor Vergata, University of Rome Tor Vergata, Rome, ItalySerena Di Cecilia, Department of Internal Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, ItalyPierpaolo Sileri, Gast... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5163103 Tue, 23 Aug 2011 15:50:22 +0100 5163103 Investigation of pretreatment prediction of proton pump inhibitor (PPI)-resistant patients with gastroesophageal reflux disease and the dose escalation challenge of PPIs—TORNADO study: a multicenter prospective study by the Acid-Related Symptom Research Group in Japan http://www.medworm.com/index.php?rid=5163104&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk145215103703722%2F Conclusions  FSSG could predict response to a PPI for symptomatic GERD. Increase of RPZ dose is useful for treatment of GERD refractory to the standard dose of RPZ. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-11DOI 10.1007/s00535-011-0446-2Authors Takahisa Furuta, Center for Clinical Research, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192 JapanTomohiko Shimatani, Department of General Medicine, Hiroshima University Hospital, Hiroshima, JapanMitsushige Sugimoto, First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, JapanShunji Ishihara, Department of Internal Medicine II, Shimane University Faculty of Medicine, Izumo, JapanYasuhiro Fujiwara, Department of Gastro... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5163104 Tue, 23 Aug 2011 05:57:49 +0100 5163104 SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans http://www.medworm.com/index.php?rid=5163105&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk5580420524k4813%2F Conclusion  SOX9 is expressed in intestinal metaplasia and gastric carcinoma in humans. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-8DOI 10.1007/s00535-011-0443-5Authors Miho Sashikawa Kimura, Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, JapanHiroyuki Mutoh, Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, JapanKentaro Sugano, Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 (Source: Journal of Gastroenterology... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5163105 Mon, 22 Aug 2011 16:00:32 +0100 5163105 Efficacy of pegylated interferon plus ribavirin combination therapy for hepatitis C patients with normal ALT levels: a matched case–control study http://www.medworm.com/index.php?rid=5163106&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk6135h4217817393%2F Conclusion  Our findings indicate that the antiviral effect of Peg-IFN plus ribavirin therapy in N-ALT patients is comparable to that for E-ALT patients irrespective of their advantageous background; however, the application of this therapy for N-ALT patients, especially for those with HCV-1, should be considered carefully. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-9DOI 10.1007/s00535-011-0455-1Authors Naoki Hiramatsu, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanYuko Inoue, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanTsugiko Oze, D... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5163106 Fri, 19 Aug 2011 15:52:19 +0100 5163106 Cancer stem cell theory in gastrointestinal malignancies: recent progress and upcoming challenges http://www.medworm.com/index.php?rid=5163107&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft4w6443961340438%2F Abstract  A growing body of evidence supports the notion that malignant tumors are heterogeneous and contain diverse subpopulations of cells with unique characteristics including the ability to initiate a tumor and metastasize. This phenomenon might be explained by the so-called cancer stem cell (CSC) theory. Recent technological developments have allowed a deeper understanding and characterization of CSCs. Even though the application of this theory to hematopoietic malignancies and solid tumors holds promise for new ways to treat cancer, it also brings some skepticism. Efficacious therapeutic approaches targeting the CSC population should be explored to overcome therapeutic failure and improve patient outcomes. This review will focus on the intrinsic and extrinsic regulati... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5163107 Fri, 19 Aug 2011 15:52:18 +0100 5163107 Introduction of an examination and treatment for Helicobacter pylori infection in high school health screening http://www.medworm.com/index.php?rid=5163108&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd1h6417100820917%2F Conclusions  The low rate of prevalence of H. pylori infection in Japanese teenagers would make it possible to perform examinations and carry out treatment for this infection in high school health screenings from the standpoint of medical economy. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-8DOI 10.1007/s00535-011-0450-6Authors Taiji Akamatsu, Endoscopy Center, Suzaka Hospital, Nagano Prefectural Hospital Organization, 1332 Suzaka, Suzaka, Nagano 382-0091, JapanShinya Ichikawa, Department of Internal Medicine, Gastroenterology, Shinshu University School of Medicine, Matsumoto, JapanSadahide Okudaira, Okudaira Clinic, Matsumoto, JapanShuichi Yokosawa, Department of Internal Medicine, Gastroenterology, Shinshu University School of Med... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5163108 Fri, 19 Aug 2011 06:38:44 +0100 5163108 Effects of 1-year administration of olmesartan on portal pressure and TGF-beta1 in selected patients with cirrhosis: a randomized controlled trial http://www.medworm.com/index.php?rid=5163109&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft57u6x8515j6t324%2F Conclusions  Olmesartan induced a mild reduction of portal pressure and TGF-beta1 for 1 year, but did not suppress hepatic fibrosis markers. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-8DOI 10.1007/s00535-011-0449-zAuthors Hisashi Hidaka, Department of Gastroenterology, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, JapanTakahide Nakazawa, Department of Gastroenterology, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, JapanAkitaka Shibuya, Department of Gastroenterology, Kitasato University East Hospital, 2-1-1 Asamizodai, Minami-ku, Sagamihara, Kanagawa 252-0380, JapanTsutomu Minamino, Department of Gastroenterology, K... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5163109 Thu, 18 Aug 2011 06:02:34 +0100 5163109 Familial pancreatic cancer and hereditary syndromes: screening strategy for high-risk individuals http://www.medworm.com/index.php?rid=5163110&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx5110008194712x8%2F Abstract  Globally, and almost evenly across nations, a familial disposition can be found in 4–10% of patients with pancreatic cancer (PC). A family history of PC is a risk for this disease and the risk level changes in correlation with the number of affected relatives. Several hereditary syndromes with potential germline mutation also have a high risk for PC; however, little is yet known regarding the genes responsible for familial pancreatic cancer (FPC). Characteristics of FPC cases are similar to those of other familial tumors, including younger onset than in sporadic cases and an ethnic difference (Ashkenazi Jewish > other Caucasian). Other risks resemble those of sporadic cases and include smoking and diabetes mellitus. People with several genetic syndr... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5163110 Wed, 17 Aug 2011 05:55:29 +0100 5163110 Percutaneous radiofrequency ablation therapy for hepatocellular carcinoma: a proposed new grading system for the ablative margin and prediction of local tumor progression and its validation http://www.medworm.com/index.php?rid=5163111&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2807050877361417%2F Conclusions  The proposed R grading method is a valid and useful method for assessing treatment efficacy, and for predicting local tumor progression after RFA. Content Type Journal ArticleCategory Original Article—Liver, Pancreas, and Biliary TractPages 1-9DOI 10.1007/s00535-011-0452-4Authors Hiroki Nishikawa, Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, Osaka, 543-0027 JapanTadashi Inuzuka, Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, Osaka, 543-0027 JapanHaruhiko Takeda, Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Tennoji-ku, Osaka, 543-0027 JapanJun Nakajima, Department of Gastroenterology and ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5163111 Tue, 16 Aug 2011 06:16:58 +0100 5163111 Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups http://www.medworm.com/index.php?rid=5163112&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq6745467n7360218%2F Conclusions  Low serum adiponectin levels may be associated with an increased risk for erosive esophagitis in men. Content Type Journal ArticleCategory Original Article—Alimentary TractPages 1-7DOI 10.1007/s00535-011-0453-3Authors Motohiko Kato, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanKenji Watabe, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanToshimitsu Hamasaki, Department of Biomedical Statistics, Osaka University Graduate School of Medicine, Suita, JapanMiyuki Umeda, Sumitomo Hospital, Osaka, JapanAiko Furubayashi, Sumitomo Hospital, Osaka, JapanKazuo Kinoshita, Sumitomo Hospital, O... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5163112 Tue, 16 Aug 2011 06:16:56 +0100 5163112 Fever-based antibiotic therapy for acute cholangitis following successful endoscopic biliary drainage http://www.medworm.com/index.php?rid=5132799&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc8274214887m4w4l%2F Conclusions  Fever-based antibiotic therapy for acute cholangitis is safe and effective when resolution of fever is achieved following endoscopic biliary drainage. Content Type Journal ArticlePages 1-7DOI 10.1007/s00535-011-0451-5Authors Hirofumi Kogure, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanTakeshi Tsujino, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanKeisuke Yamamoto, Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanSuguru Mizuno, Department of Gastroenterology, Graduate School of Medicine, The University of T... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5132799 Sat, 13 Aug 2011 06:05:29 +0100 5132799 Genetic variation in PLCE1 is associated with gastric cancer survival in a Chinese population http://www.medworm.com/index.php?rid=5132800&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F33361k5u34v56806%2F Conclusion  Our findings showed that the PLCE1 SNP rs2274223 was associated with significantly improved gastric cancer survival in a Chinese population. Further functional studies are needed to validate our results. Content Type Journal ArticlePages 1-7DOI 10.1007/s00535-011-0445-3Authors Dewei Luo, Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 ChinaYan Gao, Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029 ChinaShizhi Wang, D... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5132800 Fri, 12 Aug 2011 06:15:02 +0100 5132800 Reduction of liver stiffness by antiviral therapy in chronic hepatitis B http://www.medworm.com/index.php?rid=5110458&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb13t1u44580026u5%2F Conclusions  LS was significantly correlated with fibrosis stage in patients with chronic hepatitis B. The reduction of LS by antiviral therapy was significantly correlated with the reduction of hyaluronic acid. Thus, we conclude that LS can be useful to assess the progression and regression of liver fibrosis stage noninvasively. Content Type Journal ArticlePages 1-11DOI 10.1007/s00535-011-0444-4Authors Keisuke Osakabe, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Aichi, JapanNaohiro Ichino, Faculty of Medical Technology, School of Health Sciences, Fujita Health University, Aichi, JapanToru Nishikawa, Department of Clinical Laboratory, Fujita Health University Hospital, Aichi, JapanHiroko Sugiyama, Department of Clinical Laborat... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5110458 Sat, 06 Aug 2011 05:59:05 +0100 5110458 Clinical significance of salvage esophagectomy for remnant or recurrent cancer following definitive chemoradiotherapy http://www.medworm.com/index.php?rid=5110459&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp88603173u580748%2F Conclusions  Preoperative CRT is associated with postoperative complications especially in patients with R2 resection, while long-term survival can be achieved after R0 resections. Salvage surgery should be considered for carefully selected patients in whom R0 resection can be achieved. Content Type Journal ArticlePages 1-8DOI 10.1007/s00535-011-0448-0Authors Masaru Morita, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812- 8582 JapanRyuichi Kumashiro, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812- 8582 JapanYuichi Hisamatsu, Department of Surgery and Science, Graduate School of Medical Sciences, Kyush... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5110459 Fri, 05 Aug 2011 05:58:34 +0100 5110459 Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn’s disease rat model http://www.medworm.com/index.php?rid=5098546&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft58h57v20711735m%2F Conclusions  In the ischemic colon, endogenous βCGRP, but not ADM, was decreased. Thus, it was concluded that TU-100 ameliorated microvascular dysfunction by the up-regulation of endogenous ADM in the CD rat model. TU-100 may be a possible therapeutic agent for gastrointestinal ischemia-related diseases including CD. Content Type Journal ArticlePages 1-10DOI 10.1007/s00535-011-0438-2Authors Toru Kono, Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, 2-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, JapanYuji Omiya, Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, 2-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, JapanYoshiki Hira, Department of Ana... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5098546 Tue, 02 Aug 2011 06:14:00 +0100 5098546 Factor V Leiden and inflammatory bowel disease: a systematic review and meta-analysis http://www.medworm.com/index.php?rid=5089051&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F958g3233105763u4%2F Conclusions  This meta-analysis indicated that although Factor V Leiden mutation was not significantly associated with the risk of IBD, it was significantly associated with a higher risk of thromboembolism in IBD patients. Content Type Journal ArticlePages 1-9DOI 10.1007/s00535-011-0441-7Authors Jie Liang, State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Road, Xi’an, 710032 Shannxi, ChinaShengjun Wu, Department of Psychology, School of Aerospace Medicine, Fourth Military Medical University, 127 West ChangLe Road, Xi’an, 710032 Shannxi, ChinaBin Feng, State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 127 West ChangLe Ro... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5089051 Fri, 29 Jul 2011 16:01:56 +0100 5089051 Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia http://www.medworm.com/index.php?rid=5089050&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh6305g1682041146%2F Conclusions  Roxatidine appears to have high cost-effectiveness in the prevention of bleeding and in the promotion of ulcer healing after ESD for superficial gastric neoplasia. Content Type Journal ArticlePages 1-6DOI 10.1007/s00535-011-0447-1Authors Hiroyuki Imaeda, Department of General Internal Medicine, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, 350-0495 JapanNaoki Hosoe, Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, JapanHidekazu Suzuki, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, JapanYoshimasa Saito, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio Un... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5089050 Fri, 29 Jul 2011 16:01:56 +0100 5089050 Correlation between endocytoscopy and conventional histopathology in microstructural features of ulcerative colitis http://www.medworm.com/index.php?rid=5089052&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1327n712576876k5%2F Conclusions  Our novel ECSS has good predictive value for the histopathological activity of UC. Content Type Journal ArticlePages 1-6DOI 10.1007/s00535-011-0439-1Authors Rieko Bessho, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582 JapanTakanori Kanai, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582 JapanNaoki Hosoe, Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, JapanTaku Kobayashi, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, 160-8582 JapanTetsuro Takayama, Division of Gastroenterology an... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5089052 Fri, 29 Jul 2011 16:01:55 +0100 5089052 A large volume of visceral adipose tissue leads to severe acute pancreatitis http://www.medworm.com/index.php?rid=5089053&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg310132lu36n74j2%2F Conclusion  In acute pancreatitis, peripancreatic VAT has a stronger correlation with severe acute pancreatitis than BMI or WC. VAT volume is strongly correlated with the formation of a pseudocyst and with systemic inflammatory response syndrome in patients with acute pancreatitis and high VAT volume may lead to severe acute pancreatitis. Content Type Journal ArticlePages 1-6DOI 10.1007/s00535-011-0430-xAuthors Yoko Yashima, Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanHiroyuki Isayama, Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 JapanTakeshi Tsujino, Department of Gastroenterology, Graduate School of Medicine... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5089053 Fri, 29 Jul 2011 16:01:54 +0100 5089053 Early activation of interferon-stimulated genes in human liver allografts: relationship with acute rejection and histological outcome http://www.medworm.com/index.php?rid=5080603&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F76g2138vx78577v2%2F Conclusions  In the early postoperative period of liver transplantation, interferon-stimulated gene activation is dependent on hepatitis C recurrence (the main factor responsible for early fibrosis progression) and donor age, and is related to the risk of acute cellular rejection. Content Type Journal ArticlePages 1-9DOI 10.1007/s00535-011-0440-8Authors Rosalba Minisini, Department of Clinical and Experimental Medicine, Università del Piemonte Orientale “A. Avogadro”, Via G. Solaroli 17, 28100 Novara, ItalyPaola Giarda, Department of Clinical and Experimental Medicine, Università del Piemonte Orientale “A. Avogadro”, Via G. Solaroli 17, 28100 Novara, ItalyGlenda Grossi, Department of Clinical and Experimental Medicine, Università del Piemonte Orientale “... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5080603 Tue, 26 Jul 2011 05:51:28 +0100 5080603 Gastric acid induces mitochondrial superoxide production and lipid peroxidation in gastric epithelial cells http://www.medworm.com/index.php?rid=5070500&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7432n818t007k540%2F Conclusion  These results suggested that gastric acid, like nonsteroidal anti-inflammatory drugs (NSAIDs), induces mitochondrial superoxide production, which induces gastric cellular injury by triggering cellular lipid peroxidation and apoptosis. Content Type Journal ArticlePages 1-10DOI 10.1007/s00535-011-0434-6Authors Hirofumi Matsui, The Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanYumiko Nagano, The Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanOsamu Shimokawa, The Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanTsuyoshi Kaneko, The Graduate Schoo... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5070500 Mon, 25 Jul 2011 15:44:28 +0100 5070500 Evaluation of liver fibrosis by transient elastography using acoustic radiation force impulse: comparison with Fibroscan® http://www.medworm.com/index.php?rid=5064205&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft1rn457r7k567070%2F Conclusions  Transient elastography with ARFI is simple, non-invasive and useful for diagnosing the stage of fibrosis in chronic liver disease. The utility of ARFI was almost equivalent to that of the Fibroscan® method. Content Type Journal ArticlePages 1-11DOI 10.1007/s00535-011-0437-3Authors Hirotoshi Ebinuma, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, JapanHidetsugu Saito, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, JapanMina Komuta, Department of Pathology, School of Medicine, Keio University, Tokyo, JapanKeisuke Ojiro, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Me... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5064205 Thu, 21 Jul 2011 18:04:03 +0100 5064205 Multicenter study evaluating factors for stent patency in patients with malignant biliary strictures: development of a simple score model http://www.medworm.com/index.php?rid=5040677&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb633m235u051517h%2F Conclusion  Besides plastic stents, stricture severity requiring preceding dilation, and initial higher bilirubin level were associated with a shorter period of stent patency. A simple score model based on these factors was able to predict stent occlusion and may aid in choosing the most appropriate stent type in individual patients. Content Type Journal ArticlePages 1-7DOI 10.1007/s00535-011-0383-0Authors Petra G. A. van Boeckel, Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Room F02.618, Heidelberglaan 100, 3584 CX Utrecht, The NetherlandsEwout W. Steyerberg, Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The NetherlandsFrank P. Vleggaar, Department of Gastroenterology and Hepatology, Uni... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5040677 Thu, 14 Jul 2011 06:00:09 +0100 5040677 Eosinophilic esophagitis investigated by upper gastrointestinal endoscopy in Japanese patients http://www.medworm.com/index.php?rid=5031154&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvw30307396g85k72%2F Conclusion  The prevalence of EE in Japanese patients by upper gastrointestinal endoscopy has now been documented. Content Type Journal ArticlePages 1-3DOI 10.1007/s00535-011-0435-5Authors Hirofumi Fujishiro, Division of Endoscopy, Shimane Prefectural Central Hospital, Izumo, JapanYuji Amano, Division of Endoscopy, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, JapanYoshinori Kushiyama, Division of Gastroenterology, Matsue Red Cross Hospital, Matsue, JapanShunji Ishihara, Second Department of Internal Medicine, Shimane University, Faculty of Medicine, Izumo, JapanYoshikazu Kinoshita, Second Department of Internal Medicine, Shimane University, Faculty of Medicine, Izumo, Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5031154 Wed, 13 Jul 2011 06:03:07 +0100 5031154 Platelet count for predicting fibrosis in nonalcoholic fatty liver disease http://www.medworm.com/index.php?rid=5031153&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw017336403135043%2F Conclusions  The platelet count may be an ideal biomarker of the severity of fibrosis in NAFLD patients, because it is simple, easy to measure and handle, cost-effective, and accurate for predicting the severity of fibrosis. Furthermore, by using the platelet count cutoff value validated in our multiple large trials, efficient recruitment of NAFLD patients may be facilitated. Content Type Journal ArticlePages 1-7DOI 10.1007/s00535-011-0436-4Authors Masato Yoneda, Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, JapanHideki Fujii, Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, JapanYoshio Sumida, Center for Digestive and Liver Diseases, Nara City Hospital, Nara, JapanHideyuki Hyogo, Dep... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5031153 Wed, 13 Jul 2011 06:03:07 +0100 5031153 Expression of angiotensin II type 1 and type 2 receptor mRNAs in the gastric mucosa of Helicobacter pylori-infected Mongolian gerbils http://www.medworm.com/index.php?rid=5031155&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4156274671011l01%2F Conclusions  Gastric mucosal ATR expression gradually increases during the course of H. pylori infection. Up-regulation of the RAS in association with progressive gastric inflammation suggests a potential role of the RAS in gastric carcinogenesis. OipA appears to play a role in AT1R and AT2R expression and the resulting inflammation. Content Type Journal ArticlePages 1-10DOI 10.1007/s00535-011-0433-7Authors Mitsushige Sugimoto, Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USATomoyuki Ohno, Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX, USAYoshio Yamaoka, Department of Medicine-Gastroentero... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5031155 Wed, 13 Jul 2011 06:03:05 +0100 5031155 Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease, alcoholic liver disease, and chronic liver disease of unknown etiology: report of the nationwide survey http://www.medworm.com/index.php?rid=5031156&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn9ug548u04ww6510%2F Conclusions  The clinical features of ALC-HCC, NAFLD-HCC, and unknown HCC were clearly different. Modest intake of alcohol might have a more significant role in hepatic carcinogenesis than is presently thought. Content Type Journal ArticlePages 1-8DOI 10.1007/s00535-011-0431-9Authors Katsutoshi Tokushige, Department of Internal Medicine and Gastroenterology, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 JapanEtsuko Hashimoto, Department of Internal Medicine and Gastroenterology, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666 JapanYoshinori Horie, Department of Internal Medicine, International University of Health and Welfare, Sanno Hospital, Tokyo, JapanMakiko Taniai, Department of Internal Medicine ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5031156 Tue, 12 Jul 2011 05:59:26 +0100 5031156 Phenotype-dependent production of des-γ-carboxy prothrombin in hepatocellular carcinoma http://www.medworm.com/index.php?rid=5021607&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flj274113370qq633%2F Conclusions  HCC cells produce DCP when they undergo mild phenotypic changes. However, when HCC cells adopt mesenchymal properties they lose their capacity for protein synthesis, and the production of DCP is attenuated. Building upon our previous works, it appears that DCP could be a unique tumor marker that reflects the stepwise phenotypic changes of HCC. Content Type Journal ArticlePages 1-11DOI 10.1007/s00535-011-0432-8Authors Hideto Suzuki, Center for Community Medicine, Jichi Medical University, Shimotsuke, JapanKazumoto Murata, Center for Community Medicine, Jichi Medical University, Shimotsuke, JapanTakaya Gotoh, Center for Community Medicine, Jichi Medical University, Shimotsuke, JapanMasao Kusano, Department of Gastroenterology, Iwaki Kyoritsu General Hospit... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5021607 Sat, 09 Jul 2011 06:20:51 +0100 5021607 Gastrointestinal stem cells in self-renewal and cancer http://www.medworm.com/index.php?rid=5010466&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq57u6284635xx37m%2F Abstract  The gastrointestinal epithelium is a unique model for the study of mammalian stem cells. Not only does it have a highly stereotypical organization, its remarkable rate of self-renewal provides a daily readout of stem cell activity. The past decade has seen a major investment in developing technologies dedicated to revealing the identity of the long-elusive gastrointestinal stem cells. An array of purported stem cell biomarkers is now available for the mouse, including surface-expressed proteins that hold great promise as antibody targets for use in isolating human stem cells. Here we critically appraise the validity of these biomarkers and discuss their likely impact on our understanding of stem cell roles in self-renewal and cancer in the gastrointestinal tract. ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5010466 Mon, 04 Jul 2011 16:18:36 +0100 5010466 Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn’s disease http://www.medworm.com/index.php?rid=5010467&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj5x5876629027043%2F Conclusions   FUT2 secretor status was associated with colonic-type CD. This finding, taken together with the immunohistochemistry data, suggests that the abnormal expression of blood type antigens in the colon may be a unique and essential factor for colonic CD. Content Type Journal ArticlePages 1-8DOI 10.1007/s00535-011-0425-7Authors Jun Miyoshi, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582 JapanTomoharu Yajima, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582 JapanSusumu Okamoto, Division of Gastroenterology and Hepatology, Department of In... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=5010467 Mon, 04 Jul 2011 06:09:47 +0100 5010467 Fetal liver cell transplantation as a potential alternative to whole liver transplantation? http://www.medworm.com/index.php?rid=4971030&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm072642075038136%2F Abstract  Because organ shortage is the fundamental limitation of whole liver transplantation, novel therapeutic options, especially the possibility of restoring liver function through cell transplantation, are urgently needed to treat end-stage liver diseases. Groundbreaking in vivo studies have shown that transplanted hepatocytes are capable of repopulating the rodent liver. The two best studied models are the urokinase plasminogen activator (uPA) transgenic mouse and the fumarylacetoacetate hydrolase (FAH)-deficient mouse, in which genetic modifications of the recipient liver provide a tissue environment in which there is extensive liver injury and selection pressure favoring the proliferation and survival of transplanted hepatocytes. Because transplanted hepatocytes do ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4971030 Thu, 23 Jun 2011 06:13:08 +0100 4971030 Pancreatic cancer stem cells: new insights and perspectives http://www.medworm.com/index.php?rid=4971031&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3234gg1umr16g237%2F Abstract  Since the identification of self-renewing cells in the hematopoietic system several decades ago, stem cells have changed the way we study biology and medicine. Solid tumors contain a distinct subpopulation of cells that have stem cell characteristics and are exclusively responsible for tumorigenicity. This discovery has led to the development of the stem cell concept of cancer, which proposes that a subpopulation of self-renewing tumor cells, also termed cancer stem cells, is responsible for tumorigenesis and metastasis. This contrasts with the stochastic model of tumor development, which holds that all tumor cells are capable of tumor initiation. Different subpopulations of cancer stem cells have been identified in pancreatic ductal adenocarcinoma, based on the u... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4971031 Wed, 22 Jun 2011 16:01:47 +0100 4971031 Effect of repetitive transcranial magnetic stimulation on rectal function and emotion in humans http://www.medworm.com/index.php?rid=4971032&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd5025m4n30755m64%2F Conclusions and inferences  We successfully modulated the gastrointestinal function of healthy individuals through rTMS to the right DLPFC. Thus, rTMS to the DLPFC appears to modulate the affective, but not direct, component of visceral perception and motility of the rectum. Content Type Journal ArticlePages 1-10DOI 10.1007/s00535-011-0423-9Authors Yuuichi Aizawa, Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, 980-8575 JapanJoe Morishita, Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, 980-8575 JapanMichiko Kano, Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, 980-8575 JapanTakayuki Mori, D... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4971032 Tue, 21 Jun 2011 20:53:16 +0100 4971032 Haplotype in the IBD5 region is associated with refractory Crohn’s disease in Slovenian patients and modulates expression of the SLC22A5 gene http://www.medworm.com/index.php?rid=4971033&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F521n4w4776840l75%2F Conclusions  Our data suggest that SNPs and haplotype in the IBD5 SLC22A4/SLC22A5 region contribute to the development of particularly refractory Crohn’s disease in the Slovenian population, and expression studies in blood lymphocytes and colon tissue biopsies and eQTL analysis suggest that SLC22A5 is the main gene in the IBD5 region contributing to the IBD pathogenesis. Content Type Journal ArticlePages 1-11DOI 10.1007/s00535-011-0426-6Authors Katja Repnik, Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Slomškov trg 15, 2000 Maribor, SloveniaUroš Potočnik, Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Slomškov trg 15, 2000 Maribor, Slovenia Jou... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4971033 Tue, 21 Jun 2011 20:53:15 +0100 4971033 Systematic review of the epidemiology of gastroesophageal reflux disease in Japan http://www.medworm.com/index.php?rid=4971034&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4336364885202u87%2F Conclusions  Few studies have reported the prevalence of GERD in Japan using standardized criteria. Thus, prevalence estimates vary substantially, reflecting differences in study populations and GERD definitions. However, seven studies reported that the prevalence of at least weekly symptoms was 6.5–9.5%, a finding which approaches that reported in Western populations (10–20%). Content Type Journal ArticlePages 1-12DOI 10.1007/s00535-011-0429-3Authors Yoshikazu Kinoshita, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, JapanKyoichi Adachi, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, JapanMichio Hongo, Tohoku University Hospital, Aoba, Sendai, JapanKen Haruma, Kawasaki Medical School, Kurashiki, O... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4971034 Tue, 21 Jun 2011 20:53:13 +0100 4971034 Pretreatment prediction of anemia progression by pegylated interferon alpha-2b plus ribavirin combination therapy in chronic hepatitis C infection: decision-tree analysis http://www.medworm.com/index.php?rid=4946951&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe742v7073l158835%2F Conclusions  The decision-tree model that included Hb values at baseline, Ccr, and an Hb concentration decline by 2 g/dl at week 2 was useful for predicting the probability of severe anemia, and has the potential to support clinical decisions regarding early dose reduction of ribavirin. Content Type Journal ArticlePages 1-9DOI 10.1007/s00535-011-0412-zAuthors Naoki Hiramatsu, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, JapanMasayuki Kurosaki, Division of Gastroenterology and Hepatology, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino, Tokyo 180-8610, JapanNaoya Sakamoto, Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, JapanManabu Iwasaki, Department of C... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4946951 Fri, 17 Jun 2011 10:56:05 +0100 4946951 Daily granulocyte and monocyte adsorptive apheresis in patients with active ulcerative colitis: a prospective safety and feasibility study http://www.medworm.com/index.php?rid=4946952&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw004121776686577%2F Conclusions  This is the first report on daily GMA in the treatment of patients with UC. Daily GMA was safe and well tolerated without serious AE. Furthermore, daily GMA was associated with rapid improvement of clinical symptoms in patients with moderately active UC. However, controlled trials are warranted to assess a definite efficacy for daily GMA therapy. Content Type Journal ArticlePages 1-7DOI 10.1007/s00535-011-0428-4Authors Takayuki Yamamoto, Inflammatory Bowel Disease Center, Yokkaichi Social Insurance Hospital, 10-8 Hazuyamacho, Yokkaichi, Mie 510-0016, JapanSatoru Umegae, Inflammatory Bowel Disease Center, Yokkaichi Social Insurance Hospital, 10-8 Hazuyamacho, Yokkaichi, Mie 510-0016, JapanKoichi Matsumoto, Inflammatory Bowel Disease Center, Yokkaichi Soci... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4946952 Fri, 17 Jun 2011 10:56:04 +0100 4946952 Mucin phenotype and narrow-band imaging with magnifying endoscopy for differentiated-type mucosal gastric cancer http://www.medworm.com/index.php?rid=4938489&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw368686124wwm52q%2F Conclusions  The mucin phenotype of differentiated early gastric cancer might be involved in morphogenetic differences between the papillary and pit structures visualized by NBI-ME. Content Type Journal ArticlePages 1-7DOI 10.1007/s00535-011-0418-6Authors Masaaki Kobayashi, Department of Endoscopy, Niigata University Medical and Dental Hospital, 1-757 Asahimachi-dori, Chuo-ku, Niigata, 951-8510 JapanManabu Takeuchi, Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, JapanYoichi Ajioka, Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanSatoru Hashimoto, Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospit... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4938489 Sat, 11 Jun 2011 06:38:39 +0100 4938489 Serodiagnosis of Helicobacter hepaticus infection in patients with liver and gastrointestinal diseases: western blot analysis and ELISA using a highly specific monoclonal antibody for H. hepaticus antigen http://www.medworm.com/index.php?rid=4914524&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6280162771pu2437%2F Conclusions   H. hepaticus infection might play a role in the development of liver diseases; in particular, it might increase the risk of the development of HBV- and/or HCV-infected liver diseases. Content Type Journal ArticlePages 1-7DOI 10.1007/s00535-011-0414-xAuthors Kazunari Murakami, Department of Gastroenterology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yuhu, Oita 879-5593, JapanRyoki Takahashi, Wakamoto Pharmaceutical Co., Ltd., Sagami Research Laboratories, Ashigarakami-gun, Kanagawa, JapanMasami Ono, Department of Gastroenterology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yuhu, Oita 879-5593, JapanKoichiro Watanabe, Department of Gastroenterology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasam... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4914524 Tue, 07 Jun 2011 15:52:08 +0100 4914524 Hepatitis B virus X gene and hepatocarcinogenesis http://www.medworm.com/index.php?rid=4914525&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F740m6973100766t7%2F Abstract  Chronic hepatitis B virus (HBV) infection has been identified as a major risk factor in hepatocellular carcinoma (HCC), which is one of the most common cancers worldwide. The pathogenesis of HBV-mediated hepatocarcinogenesis is, however, incompletely understood. Evidence suggests that the HBV X protein (HBx) plays a crucial role in HCC development. HBx is a multifunctional regulator that modulates transcription, signal transduction, cell cycle progression, apoptosis, protein degradation pathways, and genetic stability through interaction with host factors. This review describes the current state of knowledge of the molecular pathogenesis of HBV-induced HCC, with a focus on the role of HBx in hepatocarcinogenesis. Content Type Journal ArticlePages 1-17DOI 10.10... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4914525 Tue, 07 Jun 2011 05:49:49 +0100 4914525 Current molecular markers for gastric progenitor cells and gastric cancer stem cells http://www.medworm.com/index.php?rid=4896256&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe66167652j154006%2F Abstract  Gastric stem and progenitor cells (GPC) play key roles in the homeostatic renewal of gastric glands and are instrumental in epithelial repair after injury. Until very recently, the existence of GPC could only be inferred by indirect labeling strategies. The last few years have seen significant progress in the identification of biomarkers that allow prospective identification of GPC. The analysis of these unique cell populations is providing new insights into the molecular underpinnings of gastric epithelial homeostasis and repair. Of closely related interest is the potential to identify so-called cancer stem cells, a rare subpopulation of tumor-initiating cells. Here, we review the current useful biomarkers for GPC, including: (a) those that have been demonstrated... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4896256 Tue, 31 May 2011 05:50:01 +0100 4896256 Differences of image enhancement in image-enhanced endoscopy: narrow band imaging versus flexible spectral imaging color enhancement http://www.medworm.com/index.php?rid=4896257&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5736878011651vn2%2F Conclusions  NBI more effectively enhanced images of diluted blood compared to conventional WLI, while FICE did not improve the visualization of the diluted blood. These data suggest the usefulness of NBI for the early detection of gastrointestinal neoplasia, which is accompanied by abundant neovascularization. Content Type Journal ArticlePages 1-5DOI 10.1007/s00535-011-0419-5Authors Manabu Muto, Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Kawahara Cho, Syogoin, Sakyo-ku, Kyoto, 606-8507 JapanHirokazu Higuchi, Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, 54 Kawahara Cho, Syogoin, Sakyo-ku, Kyoto, 606-8507 JapanYasumasa Ezoe, Department of Multidisciplinary Cancer Treat... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4896257 Wed, 25 May 2011 16:01:21 +0100 4896257 Novel classification of acute liver failure through clustering using a self-organizing map: usefulness for prediction of the outcome http://www.medworm.com/index.php?rid=4854894&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj39g71x45l618651%2F Conclusions  Clustering revealed that patients with acute liver failure could be classified into three clusters independent of the interval between the onset of disease symptoms and the development of encephalopathy. This technique may be useful, since the outcomes of the patients differed markedly among the clusters. Content Type Journal ArticlePages 1-9DOI 10.1007/s00535-011-0420-zAuthors Nobuaki Nakayama, Department of Gastroenterology and Hepatology, Faculty of Medicine, Saitama Medical University, Morohongo 38, Moroyama-Machi, Iruma-Gun, Saitama, 350-0495 JapanMakoto Oketani, Department of Digestive and Life-Style Related Disease, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, JapanYoshihiro Kawamura, Life Sciences Solutions, IBM... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4854894 Fri, 20 May 2011 16:14:00 +0100 4854894 Present status of autoimmune hepatitis in Japan: a nationwide survey http://www.medworm.com/index.php?rid=4854895&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe6172821j236565k%2F Conclusions  The clinical features of patients with AIH in Japan were clarified. The mean age at diagnosis was higher than that in previous studies. In addition, the number of patients with AIH having the histological features of acute hepatitis increased. Diagnosis of AIH does not preclude the presence of acute hepatitis and/or serum IgG levels less than 2,000 mg/dl. Content Type Journal ArticlePages 1-6DOI 10.1007/s00535-011-0421-yAuthors Masanori Abe, Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, JapanToshie Mashiba, Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0295, JapanMikio Zeniya, Department of Gastr... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4854895 Thu, 19 May 2011 16:34:10 +0100 4854895 Feasibility study of corticosteroid treatment for esophageal ulcer after EMR in a canine model http://www.medworm.com/index.php?rid=4854896&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5682v66622431m8p%2F Conclusion  It was speculated that the esophageal ulcer causes the fibrosis of the submucosa and atrophy of the muscularis propria during process of healing. Intralesional steroid injection deepened the esophageal ulcers and delayed epithelialization, whereas systemic administration did not clearly improve the lesion healing process. Content Type Journal ArticlePages 1-7DOI 10.1007/s00535-011-0400-3Authors Michitaka Honda, Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, Kyoto, 606-8507 JapanTatsuo Nakamura, Department of Bioartificial Organs, Institute for Frontier Medical Science, Kyoto University, 53 Kawahara cho, Sakyo-ku, Kyoto, 606-8507 JapanYoshio Hori, Department of Bioartificial Organs, ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4854896 Thu, 19 May 2011 16:34:08 +0100 4854896 Genetic polymorphisms in CTLA4 and SLC4A2 are differentially associated with the pathogenesis of primary biliary cirrhosis in Japanese patients http://www.medworm.com/index.php?rid=4854897&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm532272058147g58%2F Conclusions  CTLA4 and SLC4A2 genetic polymorphisms are differentially associated with PBC development and progression, as well as anti-gp210 or anti-centromere antibody production, in Japanese PBC patients. Content Type Journal ArticlePages 1-10DOI 10.1007/s00535-011-0417-7Authors Yoshihiro Aiba, Clinical Research Center, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Nagasaki 856-8562, JapanMinoru Nakamura, Clinical Research Center, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Nagasaki 856-8562, JapanSatoru Joshita, Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, JapanTatsuo Inamine, Department of Pharmacotherapeutics, Nagasaki U... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4854897 Wed, 18 May 2011 18:16:58 +0100 4854897 A retrospective cohort study of partial splenic embolization for antiviral therapy in chronic hepatitis C with thrombocytopenia http://www.medworm.com/index.php?rid=4854898&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvr50n106012230n1%2F Conclusions  IFN-based therapy following PSE had an advantage in the maintenance of higher platelet counts, and PSE possibly caused an increase in adherence to PEG-IFN. Although patients with genotype 2 might be better candidates for PSE, further evaluation is needed. Careful follow-up of PSE-treated patients, even though they may have achieved an SVR, is needed to detect HCC. Content Type Journal ArticlePages 1-10DOI 10.1007/s00535-011-0407-9Authors Hiroki Tahara, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, JapanHitoshi Takagi, Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, JapanKen... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4854898 Wed, 18 May 2011 18:16:57 +0100 4854898 Development of corpus atrophic gastritis may be associated with Helicobacter pylori-related idiopathic thrombocytopenic purpura http://www.medworm.com/index.php?rid=4854899&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F418666201681924v%2F Conclusion  The development of corpus atrophic gastritis may be a suitable condition for inducing thrombocytopenia. Evaluation of the serum, endoscopic, and histological markers of atrophic gastritis may assist in selecting patients with ITP who are more likely to respond to H. pylori eradication therapy. Content Type Journal ArticlePages 1-7DOI 10.1007/s00535-011-0416-8Authors Ryugo Sato, Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Oita, Yufu 879-5593, JapanKazunari Murakami, Department of Gastroenterology and General Medicine, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Oita, Yufu 879-5593, JapanTadayoshi Okimoto, Department of Gastroenterology and General Medicine, F... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4854899 Wed, 18 May 2011 18:16:56 +0100 4854899 Role of Th-2 cytokines in the development of Barrett’s esophagus in rats http://www.medworm.com/index.php?rid=4854900&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F61452173807t6601%2F Conclusion  Th-2 cytokines, especially IL-4, may play a crucial role in the development of Barrett’s esophagus in an early phase. These results provide understanding of the pathogenesis of Barrett’s esophagus from the aspect of the Th-2 immune response. Content Type Journal ArticlePages 1-11DOI 10.1007/s00535-011-0405-yAuthors Yukie Kohata, Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-7 Asahimachi, Abenoku, Osaka, 545-8585 JapanYasuhiro Fujiwara, Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-7 Asahimachi, Abenoku, Osaka, 545-8585 JapanHirohisa Machida, Department of Gastroenterology, Osaka City University Graduate School of Medicine, 1-4-7 Asahimachi, Abenoku, Osaka, 545-8585 JapanH... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4854900 Wed, 18 May 2011 06:14:29 +0100 4854900 An open-label, single-arm study assessing the efficacy and safety of l-menthol sprayed onto the gastric mucosa during upper gastrointestinal endoscopy http://www.medworm.com/index.php?rid=4822666&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa55nv47266701105%2F Conclusion  These findings are comparable to those of the phase III placebo-controlled study and provide further evidence that endoscopic direct spraying of l-menthol effectively suppresses gastric peristalsis during upper gastrointestinal endoscopy. Content Type Journal ArticlePages 1-10DOI 10.1007/s00535-011-0395-9Authors Naoki Hiki, Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo, 135-8550 JapanMichio Kaminishi, Showa General Hospital, Tokyo, JapanSatoshi Tanabe, Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, JapanJunko Fujisaki, Division of Endoscopy, Cancer Institute Ariake Hospital, Japanese Foundation for ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4822666 Wed, 11 May 2011 05:50:46 +0100 4822666 Differential alteration of CD56bright and CD56dim natural killer cells in frequency, phenotype, and cytokine response in chronic hepatitis C virus infection http://www.medworm.com/index.php?rid=4822667&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F21612qu04818680u%2F Conclusions  These results indicate alterations of NK cell subsets in frequency, phenotype, and cytokine response in CHC, which might be associated with the immune pathogenesis of CHC. Content Type Journal ArticlePages 1-11DOI 10.1007/s00535-011-0408-8Authors Takuya Miyagi, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, JapanSatoshi Shimizu, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, JapanTomohide Tatsumi, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, JapanKumiko Nishio, Department of Gastroenterology and Hepatol... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4822667 Wed, 11 May 2011 05:50:45 +0100 4822667 Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: a pilot randomized controlled study http://www.medworm.com/index.php?rid=4822668&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx7811l2582263183%2F Conclusions  Co-administration of L. casei is effective for the treatment of aspirin-associated small bowel injury. Content Type Journal ArticlePages 1-12DOI 10.1007/s00535-011-0410-1Authors Hiroki Endo, Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 JapanTakuma Higurashi, Department of Gastroenterology, Yokohama Rosai Hospital, 3211 Kozukue, Kohoku-ku, Yokohama, JapanKunihiro Hosono, Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 JapanEiji Sakai, Division of Gastroenterology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004 JapanYusuke Sekino, Division of Gastroenterology, Yokohama Ci... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4822668 Tue, 10 May 2011 06:03:33 +0100 4822668 Antiviral effects of peginterferon alpha-2b and ribavirin following 24-week monotherapy of telaprevir in Japanese hepatitis C patients http://www.medworm.com/index.php?rid=4822669&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm82r045h57348115%2F Conclusions  Anemia was manageable by carefully adjusting the ribavirin dosage in the standard therapy that followed telaprevir monotherapy. This sequential regimen seems to be safer and more tolerable than the triple combination of telaprevir, peginterferon alpha, and ribavirin, especially among elderly females with low baseline hemoglobin. Content Type Journal ArticlePages 1-9DOI 10.1007/s00535-011-0411-0Authors Itaru Ozeki, Department of Gastroenterology, Sapporo Kosei General Hospital, North-3 East-8, Chuou-Ku, Sapporo, Hokkaido 060-0033, JapanJun Akaike, Department of Gastroenterology, Sapporo Kosei General Hospital, North-3 East-8, Chuou-Ku, Sapporo, Hokkaido 060-0033, JapanYoshiyasu Karino, Department of Gastroenterology, Sapporo Kosei General Hospital, North-... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4822669 Tue, 10 May 2011 06:03:31 +0100 4822669 The efficacy of extended treatment with pegylated interferon plus ribavirin in patients with HCV genotype 1 and slow virologic response in Japan http://www.medworm.com/index.php?rid=4806771&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F84r06lpj2w20368r%2F Conclusions  An earlier response predicts a higher SVR rate in patients with an LVR given 72-week treatment. Extended treatment with Peg-IFN plus ribavirin for patients with an LVR improved the treatment efficacy, even for aged patients. Content Type Journal ArticlePages 1-9DOI 10.1007/s00535-011-0403-0Authors Tsugiko Oze, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanNaoki Hiramatsu, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanTakayuki Yakushijin, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, JapanKiyoshi... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4806771 Fri, 06 May 2011 16:18:33 +0100 4806771 Treatment of non-erosive reflux disease with a proton pump inhibitor in Chinese patients: a randomized controlled trial http://www.medworm.com/index.php?rid=4783240&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F454g3kg531201854%2F Conclusions  This study suggests that esomeprazole is efficacious in treating Chinese patients with non-erosive reflux disease. Content Type Journal ArticlePages 1-7DOI 10.1007/s00535-011-0402-1Authors Victoria P. Y. Tan, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, ChinaWai M. Wong, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, ChinaTing K. Cheung, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, ChinaKam C. Lai, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, ChinaIvan F. N. Hung, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, ChinaPierre Chan, Department of Medicine, Queen Mary Hospital, University of... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4783240 Mon, 02 May 2011 15:01:17 +0100 4783240 Efficacy of re-treatment with pegylated interferon plus ribavirin combination therapy for patients with chronic hepatitis C in Japan http://www.medworm.com/index.php?rid=4783241&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftu3723223k82682h%2F Conclusions  Re-treatment of genotype 1 patients should be limited to patients with a p-EVR in the previous treatment and a low HCV RNA level at the start of re-treatment. In re-treatment with Peg-IFN plus ribavirin, longer treatment duration can contribute to increasing the anti-viral effect. Content Type Journal ArticlePages 1-7DOI 10.1007/s00535-011-0409-7Authors Tsugiko Oze, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, JapanNaoki Hiramatsu, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka 565-0871, JapanTakayuki Yakushijin, Department of Gastroenterology and Hepatology, Osaka University Graduate School of ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4783241 Mon, 02 May 2011 15:01:15 +0100 4783241 EUS-FNA for suspected malignant biliary strictures after negative endoscopic transpapillary brush cytology and forceps biopsy http://www.medworm.com/index.php?rid=4783243&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F18643j8074072115%2F Conclusions  EUS-FNA is a sensitive and safe diagnostic modality for patients with suspected MBS and can be an additional option in cases where endoscopic brush cytology and biopsy have produced negative results. Content Type Journal ArticlePages 1-8DOI 10.1007/s00535-011-0404-zAuthors Yasuhiro Ohshima, First Department of Internal Medicine, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194 JapanIchiro Yasuda, First Department of Internal Medicine, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194 JapanHiroshi Kawakami, Department of Gastroenterology, Hokkaido University Hospital, Sapporo, JapanMasaki Kuwatani, Department of Gastroenterology, Hokkaido University Hospital, Sapporo, JapanTsuyoshi Mukai, First Department of Internal Medicine, Gifu University Ho... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4783243 Wed, 27 Apr 2011 08:44:27 +0100 4783243 Future aspects of therapy for hepatitis B virus infection: value of surrogate markers, innovative therapy, and global collaboration http://www.medworm.com/index.php?rid=4783242&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F144285545r814077%2F Abstract  Both optimism and frustration exist regarding therapy for patients with chronic hepatitis B virus infection. Due to the recent advent of several drugs with potent antiviral capacities and comparatively low rates of adverse effects, considerable optimism has developed regarding the treatment of these patients. Chronic hepatitis B is now a treatable disease, and suppression of hepatitis B virus replication, normalization of alanine aminotransferase levels, seronegativity/seroconversion of hepatitis B e antigen and hepatitis B surface antigen, and decreased hepatic inflammation and liver fibrosis have been documented in chronic hepatitis B virus-infected patients treated with antiviral therapy. In contrast, many frustrations regarding antiviral therapy for chronic he... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4783242 Wed, 27 Apr 2011 08:44:27 +0100 4783242 Liver functional volumetry for portal vein embolization using a newly developed 99mTc-galactosyl human serum albumin scintigraphy SPECT–computed tomography fusion system http://www.medworm.com/index.php?rid=4768823&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwpx76072g1336608%2F Conclusions  The 99mTc-GSA scintigraphy SPECT–CT fusion system can estimate the correct functional liver volume and is useful in comparison with conventional CT volumetry. Content Type Journal ArticlePages 1-6DOI 10.1007/s00535-011-0406-xAuthors Toru Beppu, Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556 JapanHiromitsu Hayashi, Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556 JapanHirohisa Okabe, Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556 JapanToshiro Masuda, Department of Gastroenterological Surgery, Graduate S... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4768823 Tue, 26 Apr 2011 15:46:09 +0100 4768823 The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus http://www.medworm.com/index.php?rid=4749083&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa5127mh8532q658v%2F Conclusions  Particle radiotherapy is thought to be potentially effective and safe for HCC with IVCTT. Considering the current lack of effective and less-invasive local therapy for HCC with IVCTT, particle radiotherapy may therefore be an attractive new therapeutic approach for this type of HCC. Content Type Journal ArticlePages 1-8DOI 10.1007/s00535-011-0398-6Authors Shohei Komatsu, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017 JapanTakumi Fukumoto, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017 JapanYusuke Demizu, Department of Radiology, Hyogo... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4749083 Fri, 22 Apr 2011 16:02:07 +0100 4749083 EUS elastography combined with the strain ratio of tissue elasticity for diagnosis of solid pancreatic masses http://www.medworm.com/index.php?rid=4745313&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Frj558418857gw756%2F Conclusions  Endoscopic ultrasound elastography is a promising diagnostic tool for defining the tissue characteristics of pancreatic masses. In addition, semiquantitative analysis of elasticity using the SR may allow the differentiation of MFP from PC. Content Type Journal ArticlePages 1-11DOI 10.1007/s00535-011-0399-5Authors Fumihide Itokawa, Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023 JapanTakao Itoi, Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023 JapanAtsushi Sofuni, Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023 JapanToshio Kurihara, Dep... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4745313 Wed, 20 Apr 2011 06:08:26 +0100 4745313 Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial http://www.medworm.com/index.php?rid=4726471&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flt6l20l22g302ut4%2F Conclusion  Lansoprazole was superior to gefarnate in reducing the risk of gastric or duodenal ulcer recurrence in patients with a definite history of gastric or duodenal ulcers who required long-term LDA therapy. Content Type Journal ArticlePages 1-12DOI 10.1007/s00535-011-0397-7Authors Kentaro Sugano, Division of Gastroenterology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, JapanYasushi Matsumoto, Department of Neuroendovascular Therapy, Kohnan Hospital, Nagamachi-Minami, Taihaku-ku, Sendai, Miyagi 982-8523, JapanTsukasa Itabashi, Hokusetsu General Hospital, 6-24 Kita-Yanagawacho, Takatsuki, Osaka 569-0000, JapanSumihisa Abe, Koukan Clinic, 1-2-1 Koukan Dori, Kawasaki-ku, Kawasaki, Kanagawa 210-0852, Jap... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4726471 Fri, 15 Apr 2011 15:46:57 +0100 4726471 Factors predictive of relapse and spontaneous remission of autoimmune pancreatitis patients treated/not treated with corticosteroids http://www.medworm.com/index.php?rid=4726472&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl38681lp63274314%2F Conclusion  AIP patients with IgG4 seropositivity and jaundice are at a higher risk of relapse and they could therefore be candidates for over 3 years of maintenance CST. AIP patients with IgG4 seronegativity have a high likelihood of SR. Content Type Journal ArticlePages 1-9DOI 10.1007/s00535-011-0393-yAuthors Kensuke Kubota, Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, Yokohama, 236-0004 JapanSeitaro Watanabe, Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, Yokohama, 236-0004 JapanTakashi Uchiyama, Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Fukuura 3-9, Kanazawa, Yokohama, 236-0004 JapanShingo Kato, Di... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4726472 Thu, 14 Apr 2011 05:51:39 +0100 4726472 The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk http://www.medworm.com/index.php?rid=4687089&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv453130575h41731%2F Conclusion  The combination of serum TFF3 and PG testing might be a valid non-endoscopic biomarker for predicting the presence of gastric cancer. Content Type Journal ArticlePages 1-10DOI 10.1007/s00535-011-0396-8Authors Mitsuru Kaise, Department of Gastroenterology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470 JapanJun Miwa, Department of Gastroenterology, Toshiba General Hospital, Tokyo, JapanJun Tashiro, Department of Gastroenterology, Toshiba General Hospital, Tokyo, JapanYasukazu Ohmoto, Institute of Biomedical Innovation, Otsuka Pharmaceutical Co., Ltd, Tokushima, JapanShingo Morimoto, Health Medical Center, Nomura Hospital, Tokyo, JapanMasayuki Kato, Department of Endoscopy, The Jikei University School of Medicine, Tokyo, JapanMitsuyoshi Uras... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4687089 Thu, 31 Mar 2011 17:37:06 +0100 4687089 [Without Title] http://www.medworm.com/index.php?rid=4659691&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm1275v35l51034r2%2F Content Type Journal Article Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 Journal Volume Volume 46 Journal Issue Volume 46, Number 3 (Source: Journal of Gastroenterology) Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4659691 Thu, 31 Mar 2011 16:54:57 +0100 4659691 Oxidative stress is closely associated with tumor angiogenesis of hepatocellular carcinoma http://www.medworm.com/index.php?rid=4672071&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb66772lj3k78u514%2F Conclusions  OS enhances the malignant potential of HCC through the stimulation of angiogenesis by activation of the Akt-VEGF pathway. Content Type Journal ArticlePages 1-13DOI 10.1007/s00535-011-0392-zAuthors Masayasu Jo, Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566 JapanTaichiro Nishikawa, Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566 JapanTomoki Nakajima, Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566 JapanYoshi... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4672071 Wed, 30 Mar 2011 23:55:36 +0100 4672071 Pomalidomide suppresses cerulein-induced acute pancreatitis in mice http://www.medworm.com/index.php?rid=4645338&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F66958qm47j11565p%2F Conclusions  Treatment with pomalidomide ameliorated the severity of cerulein-induced acute pancreatitis in mice. Our data suggest that pomalidomide may become a new therapeutic agent in future clinical trials for the treatment of acute pancreatitis. Content Type Journal ArticlePages 1-12DOI 10.1007/s00535-011-0394-xAuthors Ming Jen Tsai, Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, 970 TaiwanChinpiao Chen, Department of Chemistry, National Dong Hwa University, Hualien, 974 TaiwanSung-Ho Chen, Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, 970 TaiwanYen Ta Huang, Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, 970 TaiwanTed H. Chiu, Institute of Pharmacology and Toxicology, Tzu Chi University, Hu... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4645338 Fri, 25 Mar 2011 05:50:26 +0100 4645338 Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease http://www.medworm.com/index.php?rid=4578650&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft44q471mp82520q3%2F Abstract  Recent studies have suggested the existence of two subtypes of autoimmune pancreatitis (AIP): type 1 AIP, related to IgG4 (lymphoplasmacytic sclerosing pancreatitis); and type 2 AIP, related to a granulocytic epithelial lesion (idiopathic duct-centric chronic pancreatitis). Compared with type 2 AIP, the clinicopathological features of type 1 AIP, with increased serum IgG4/IgE levels, abundant infiltration of IgG4 + plasmacytes and lymphocytes, autoantibodies, and steroid responsiveness, are more suggestive of abnormal immunity such as allergy or autoimmunity. Moreover, patients with type 1 AIP often have extrapancreatic lesions, such as sclerosing cholangitis, sclerosing sialadenitis, or retroperitoneal fibrosis, showing pathological features similar to ... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4578650 Thu, 10 Mar 2011 06:56:20 +0100 4578650 Cell lineage dynamics in the process leading to intestinal metaplasia http://www.medworm.com/index.php?rid=4567304&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6742070n0rv780ll%2F Conclusions  A dramatic increase in intestine-specific gene expression precedes the morphological appearance of intestinal metaplasia and spasmolytic polypeptide-expressing metaplasia. Content Type Journal ArticlePages 1-9DOI 10.1007/s00535-011-0391-0Authors Hirotsugu Sakamoto, Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, JapanHiroyuki Mutoh, Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, JapanHiroko Hayakawa, Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, JapanMiho Sashikawa, Division of Gastroenterology, Department of Medicin... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4567304 Mon, 07 Mar 2011 17:01:58 +0100 4567304 Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease http://www.medworm.com/index.php?rid=4562126&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F78m43244685r3012%2F Conclusions  Our data indicate that the dispersion of claudin-3 from esophageal epithelial plasma membranes to cytoplasm and the resulting instability of the TJ complex could be one of the most specific and sensitive indicators for monitoring inflammatory and recovery processes in RE. Content Type Journal ArticlePages 1-10DOI 10.1007/s00535-011-0390-1Authors Masako Oguro, Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 JapanMasato Koike, Department of Cell Biology and Neuroscience, Juntendo University School of Medicine, Tokyo, JapanTakashi Ueno, Department of Biochemistry, Juntendo University School of Medicine, Tokyo, JapanDaisuke Asaoka, Department of Gastroenterology, Juntendo University School of Me... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4562126 Fri, 04 Mar 2011 11:06:47 +0100 4562126 Clinical features and prognosis in patients with hepatocellular carcinoma that developed after hepatitis C virus eradication with interferon therapy http://www.medworm.com/index.php?rid=4562127&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe64mt578w1354064%2F Conclusion  We found that, despite HCV eradication, patients with the risk factors of high age at HCV eradication and heavy alcohol intake might be at heightened risk for the development of HCC within 5 years after HCV eradication. In contrast, risk factors for the development of HCC more than 10 years after HCV eradication were uncertain. These findings indicate the need for long-term surveillance for HCC after HCV eradication. Content Type Journal ArticlePages 1-10DOI 10.1007/s00535-011-0384-zAuthors Yuko Nagaoki, Programs for Biomedical Research, Division of Frontier Medical Science, Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551 JapanHiroshi Aikata, Pro... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4562127 Fri, 04 Mar 2011 11:06:45 +0100 4562127 Reply to the letter by J. Molina-Infante et al. regarding “Patients with esophageal eosinophilia” http://www.medworm.com/index.php?rid=4562128&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd8um2n43t171m626%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00535-011-0389-7Authors Yasuhiko Abe, Sendai, JapanKatsunori Iijima, Sendai, JapanTomoyuki Koike, Sendai, JapanTooru Shimosegawa, Sendai, Japan Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 (Source: Journal of Gastroenterology) Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4562128 Fri, 04 Mar 2011 11:06:44 +0100 4562128 A randomized controlled trial of rebamipide plus rabeprazole for the healing of artificial ulcers after endoscopic submucosal dissection http://www.medworm.com/index.php?rid=4541681&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8619702376k7h1k5%2F Conclusion  Treatment with a PPI plus rebamipide improved healing rates at 8 weeks for patients with ESD-derived artificial ulcer, and appeared to be particularly effective for patients with severe atrophic gastritis. Content Type Journal ArticlePages 1-8DOI 10.1007/s00535-011-0372-3Authors Shoko Fujiwara, Department of Gastroenterology, Kobe University, School of Medicine, Kobe, JapanYoshinori Morita, Department of Gastroenterology, Kobe University, School of Medicine, Kobe, JapanTakashi Toyonaga, Department of Endoscopy, Kobe University, School of Medicine, Kobe, JapanFumi Kawakami, Department of Histopathology, Kobe University, School of Medicine, Kobe, JapanTomoo Itoh, Department of Histopathology, Kobe University, School of Medicine, Kobe, JapanMasaru Yoshid... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4541681 Fri, 25 Feb 2011 17:04:55 +0100 4541681 Gastric acid secretion level modulates the association between Helicobacter pylori infection and low-dose aspirin-induced gastropathy http://www.medworm.com/index.php?rid=4541682&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy7x72381k1768661%2F Conclusions  This study has demonstrated that aspirin-induced gastropathy is directly associated with gastric acid secretion. In addition, it also suggested that the gastric acid secretion level modulates the association between H. pylori infection and aspirin-induced gastropathy. Content Type Journal ArticlePages 1-8DOI 10.1007/s00535-011-0385-yAuthors Katsunori Iijima, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, Sendai, Miyagi 980-8574, JapanNobuyuki Ara, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiryo-machi, Aobaku, Sendai, Miyagi 980-8574, JapanYasuhiko Abe, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, 1-1 Seiry... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4541682 Fri, 25 Feb 2011 17:04:54 +0100 4541682 Survey on the prevalence of GERD and FD based on the Montreal definition and the Rome III criteria among patients presenting with epigastric symptoms in Japan http://www.medworm.com/index.php?rid=4541683&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx370528575244gh8%2F Conclusion  A highly specific disease classification is possible when the Montreal definition and the Rome III criteria are strictly applied. On the other hand, the present survey highlighted a problem with the criteria whereby a definitive diagnosis could not be made in a substantial number of patients. This problem will require further research. Content Type Journal ArticlePages 1-9DOI 10.1007/s00535-011-0382-1Authors Shuichi Ohara, Department of Gastroenterology, Tohoku Rosai Hospital, 4-3-21 Dainohara, Aoba-ku, Sendai, Miyagi 981-8563, JapanTatsuyuki Kawano, Department of Surgery, Tokyo Medical and Dental University, Tokyo, JapanMotoyasu Kusano, Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Gunma, JapanTeruo Kouzu, Department of Endos... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4541683 Fri, 25 Feb 2011 17:04:52 +0100 4541683 Development of an experimental model of cholestasis induced by hypoxic/ischemic damage to the bile duct and liver tissues in infantile rats http://www.medworm.com/index.php?rid=4541684&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn5513t36056n1n15%2F Conclusion  Reduced blood flow in the EBD during infancy induced BDPF and obstructive changes in the EBD, which may, along with immature PVP and inflammatory changes in the EBD, contribute to hypoxia/ischemia of the EBD. Content Type Journal ArticlePages 1-9DOI 10.1007/s00535-010-0330-5Authors Fumiaki Toki, Pediatric Surgical Unit, Department of General Surgical Science, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, JapanAtsushi Takahashi, Pediatric Surgical Unit, Department of General Surgical Science, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, JapanMakoto Suzuki, Pediatric Surgical Unit, Department of General Surgical Science, Gunma University Hospital, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, JapanSay... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4541684 Thu, 24 Feb 2011 17:24:05 +0100 4541684 Molecular targeted therapy for hepatocellular carcinoma in the current and potential next strategies http://www.medworm.com/index.php?rid=4541685&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm4222v68u2046808%2F Abstract  Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and its incidence is still increasing. While the primary curative treatment for HCC is surgical resection, a major obstacle for the treatment of HCC is the high frequency of tumor recurrence even after curative resection. Effective palliative treatment is hindered by the evidence that HCC is frequently resistant to conventional chemotherapy and radiotherapy. Targeted therapy which specifically inhibits molecular abnormalities has emerged as a novel approach for the innovative and effective medical treatment of malignancies. In order to fulfill this promise there is an urgent need to identify the optimal targets for the treatment of HCC. A multi-kinase angiogenesis inhibitor, sorafenib,... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4541685 Thu, 24 Feb 2011 17:24:00 +0100 4541685 Proton pump inhibitors therapy for esophageal eosinophilia: simply following consensus guidelines http://www.medworm.com/index.php?rid=4541686&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F16744t0753g0v7r4%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s00535-011-0388-8Authors Javier Molina-Infante, Unit of Gastroenterology, Hospital San Pedro de Alcantara, C/Pablo Naranjo s/n, 10003 Caceres, Caceres SpainMoises Hernandez-Alonso, Unit of Gastroenterology, Hospital San Pedro de Alcantara, C/Pablo Naranjo s/n, 10003 Caceres, Caceres SpainGema Vinagre-Rodriguez, Unit of Gastroenterology, Hospital San Pedro de Alcantara, C/Pablo Naranjo s/n, 10003 Caceres, Caceres SpainElisa Martin-Noguerol, Unit of Gastroenterology, Hospital San Pedro de Alcantara, C/Pablo Naranjo s/n, 10003 Caceres, Caceres Spain Journal Journal of GastroenterologyOnline ISSN 1435-5922Print ISSN 0944-1174 (Source: Journal of Gastroenterology) Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4541686 Wed, 23 Feb 2011 23:33:45 +0100 4541686 Hybrid training of voluntary and electrical muscle contractions reduces steatosis, insulin resistance, and IL-6 levels in patients with NAFLD: a pilot study http://www.medworm.com/index.php?rid=4513706&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq01361034573h086%2F Conclusion  Hybrid training of voluntary and electrical muscle contractions improved hepatic steatosis and reduced insulin resistance and serum IL-6 levels in NAFLD patients who are resistant to lifestyle counseling. Content Type Journal ArticlePages 1-12DOI 10.1007/s00535-011-0378-xAuthors Takumi Kawaguchi, Department of Digestive Disease Information and Research, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011 JapanNaoto Shiba, Division of Rehabilitation, Kurume University Hospital, Kurume, JapanTakashi Maeda, Division of Rehabilitation, Kurume University Hospital, Kurume, JapanToru Matsugaki, Department of Orthopedic Surgery, Kurume University School of Medicine, Kurume, 830-0011 JapanYoshio Takano, Division of Rehabilitation, Kurume Universi... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4513706 Mon, 21 Feb 2011 17:08:19 +0100 4513706 Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells http://www.medworm.com/index.php?rid=4503137&cid=s_33349_17_f&fid=33349&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft81q0624j4234406%2F Conclusion  These results indicate that sorafenib is a potent agent that may provide a new therapeutic option for human ICC. Content Type Journal ArticlePages 1-11DOI 10.1007/s00535-011-0380-3Authors Hiroaki Sugiyama, Department of Gastroenterology, Institute of Clinical Medicine, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Ibaraki JapanKenichiro Onuki, Department of Surgery, Institute of Gastroenterology, Tokyo Women’s Medical University, Shinjuku-ku, Tokyo, JapanKazunori Ishige, Department of Gastroenterology, Institute of Clinical Medicine, University of Tsukuba Graduate School of Comprehensive Human Sciences, Tsukuba, Ibaraki JapanNobue Baba, Pharmacodynamics Group, Drug Development Service Division, Medi-Chem Business Segment, I... Journal of Gastroenterology journals http://www.medworm.com/rss/comments.php?id=4503137 Thu, 17 Feb 2011 16:59:43 +0100 4503137