MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Hematopathology' source. Thu, 09 Feb 2012 00:42:17 +0100 http://www.medworm.com/index.php?rid=5661207&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F76gn5823745r54u2%2F Abstract  Polymerase chain reaction (PCR) of the antigen receptor genes has clinical utility in establishing clonality in lymphoproliferations, which is an important correlate of lymphoid neoplasia. The most frequently used procedures for this purpose were developed by the BIOMED-2 consortium. One of the criteria for establishing monoclonality using PCR of the antigen receptor genes is the finding of an abundant amplicon within a size range determined by the positions of the PCR primers and the known variability in size inherent in the recombination events that assemble a functional antigen receptor gene. However, several cases have been reported in which an amplicon outside this size range has been shown to be a valid indicator of clonality after DNA sequence analysis. In ... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5661207 Fri, 03 Feb 2012 07:19:24 +0100 5661207 http://www.medworm.com/index.php?rid=5639890&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq306g1332427u3g2%2F We report a second case of a young 18-year-old girl presenting with HUS and normal platelet counts. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s12308-011-0130-8Authors Kalpita Hatti, Rochester General Hospital Internal Medicine Residency Program, 1425 Portland avenue, Rochester, NY 14621, USAMaria Rojas, Rochester General Hospital, 1425 Portland avenue, Rochester, NY 14621, USAPeter Kouides, Rochester General Hospital, Mary M. Gooley Hemophilia Center, Hemophilia Thrombosis Research Society, University of Rochester School of Medicine and Roswell Park Memorial Cancer Institute, 1425 Portland avenue, Rochester, NY 14621, USA Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5639890 Tue, 24 Jan 2012 07:54:05 +0100 5639890 http://www.medworm.com/index.php?rid=5639891&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx20jr13135787hu6%2F Abstract  Immunoglobulin Kappa light chain gene (IGK) rearrangements are important complementary PCR targets for clonality assessment in mature B-cell proliferations in which detection of clonal VH-JH gene rearrangements fails. Failure to amplify VH-JH rearrangements is mainly attributable to somatic hypermutation. Detection of clonal IGK rearrangements is most relevant in the diagnosis of germinal center (GC) and post-GC B-cell lymphomas that are under a heavy somatic mutation process. Here we present three cases in which histology and immunophenotype of the tissue samples at time of diagnosis were inconclusive. PCR-based B-cell clonality assessment was performed using the standardized BIOMED-2 multiplex PCR protocols and Genescan analysis. No clonal VH-JH rearrangements wer... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5639891 Tue, 24 Jan 2012 07:54:03 +0100 5639891 http://www.medworm.com/index.php?rid=5612006&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2524134l2122pp81%2F Abstract  We investigated the value and degree of agreement between a sensitive four-colour flow cytometry (FC) method and bone marrow trephine (BMT) biopsy for detecting minimal residual disease (MRD) in 82 chronic lymphocytic leukaemia (CLL) cases. Concordance was 85%, with 15% of cases discrepant (six BMT-positive/FC-negative and six BMT-negative/FC-positive cases). FC-positive/BMT-negative cases had a low-level MRD by FC (0.05–0.9%), whereas BMT-positive/FC-negative cases had significant residual nodular disease. We conclude that FC and BMT biopsy are complementary investigations for MRD assessment in CLL, and both should be considered in the routine setting to assess MRD in CLL. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s12308-011-... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5612006 Tue, 17 Jan 2012 07:07:47 +0100 5612006 http://www.medworm.com/index.php?rid=5612007&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F10606106t081581r%2F Abstract  Diagnostic hematopathology requires a multiparametric approach and integration of morphologic findings with the clinical, immunophenotypic, and other features. As hematopathology moves into an increasingly digital era, internet-deployed teaching sets consisting of whole slide images (WSI) and comprehensive ancillary information can help prepare hematopathology trainees for the future. Approximately 200 hematopathology conference cases over a 1-year period were de-identified, and case information (including clinical, microscopic and immunophenotypic features, flow cytometric histograms, and cytogenetic and molecular results) were entered into a database. Approximately 1,800 WSI were prepared by scanning using ×40 magnification, and WSI and supplemental data were s... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5612007 Tue, 17 Jan 2012 07:07:46 +0100 5612007 http://www.medworm.com/index.php?rid=5599907&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa752071k04667442%2F Abstract   ALK-positive anaplastic large cell lymphoma (ALCL) with identical primary genetic aberration present with variable morphology. The eponymous anaplastic large cell morphology can be detected in the majority cases which are described as being of common type morphology. However, morphological variants displaying small tumor cells that are barely distinguishable from reactive lymphocytes occur often in combination with classical large tumor cells and characterize so-called non-common type ALCL. This subgroup has recently been shown to be associated with a weak immune response to the ALK1 protein and a poorer outcome in children. Expression of T cell markers like CD3 is often reduced or absent in these lymphomas, probably as a direct effect of the ALK1 protein. In non... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5599907 Fri, 13 Jan 2012 16:48:46 +0100 5599907 http://www.medworm.com/index.php?rid=5585688&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx96n8284578kj8t2%2F Abstract  The BIOMED-2 group developed and approved a set of multiplex Ig and T cell receptor PCR primers and successfully applied these to different well-defined WHO lymphoma entities with unprecedented high frequencies of malignant cases showing clonality. This approach has now become a worldwide standard of clonality testing in lymphoproliferations. While the clonality testing and assessment by GeneScan and/or heteroduplex analysis has become relatively easy to perform, the evaluation of the obtained gene rearrangement patterns can be difficult. In this review, we will address specific aspects of clonality testing, concerning both the practical phase as the evaluation of the obtained gene rearrangement patterns, which will help to overcome problems that can be encountere... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5585688 Tue, 10 Jan 2012 16:57:36 +0100 5585688 http://www.medworm.com/index.php?rid=5573446&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh834703kq3620700%2F Abstract  MYC rearrangements are frequently associated with aggressive B-cell lymphomas, such as Burkitt’s lymphoma. We sought surrogate markers of MYC rearrangements that might obviate the need for a complex and expensive technique such as fluorescent in situ hybridization (FISH). We show that numbers of CD68+ macrophages/dendritic cells (DCs), DC-SIGN+ myeloid DCs and CD123+ plasmacytoid DCs fail to correlate with MYC rearrangement, although a starry sky appearance shows positive correlation (p = 0.003) when statistical analysis is performed on all three diagnostic groups together. We conclude that FISH is required to investigate the presence of a MYC rearrangement in cases of aggressive B-cell lymphoma, in order to guide the chemotherapeutic regime offered to the pa... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5573446 Wed, 04 Jan 2012 06:58:24 +0100 5573446 http://www.medworm.com/index.php?rid=5546088&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgq883354w677t299%2F Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.1007/s12308-011-0126-4Authors Mireille J. Hardie, PathWest Laboratory Medicine, QEII Medical Centre; and School of Pathology and Laboratory Medicine, University of Western Australia, Hospital Avenue, Nedlands, WA, AustraliaIsaac A. Thyer, Urology Department, Royal Perth Hospital, Wellington St, East Perth, WA, AustraliaTindaro Giardina, PathWest Laboratory Medicine, QEII Medical Centre, Hospital Avenue, Nedlands, WA, AustraliaMichael A. Platten, PathWest Laboratory Medicine, QEII Medical Centre, Hospital Avenue, Nedlands, WA, AustraliaMartin J. Hudson, Geraldton Regional Hospital, Shenton Street, Geraldton, WA, AustraliaPaul J. Drury, Geraldton Regional Hospital, Shenton Street, Geraldton, WA, AustraliaDominic Spagnolo, Pa... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5546088 Wed, 21 Dec 2011 20:08:46 +0100 5546088 http://www.medworm.com/index.php?rid=5516647&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn761421610558447%2F Content Type Journal ArticleCategory Case ReportPages 1-8DOI 10.1007/s12308-011-0123-7Authors Rashmi Kanagal-Shamanna, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USACarlos E. Bueso-Ramos, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USASu S. Chen, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USALynne V. Abruzzo, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAMarcos J. de Lima, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USARachel L. Sargent, Department of Hematopathology, The University of Texas MD Anderson... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5516647 Wed, 14 Dec 2011 16:30:53 +0100 5516647 http://www.medworm.com/index.php?rid=5507285&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh7v18188r7l5m54j%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12308-011-0127-3Authors Marián Švajdler, Department of pathology, L.Pasteur University Hospital, Trieda SNP 1, Košice, SlovakiaLucia Fröhlichová, Department of pathology, L.Pasteur University Hospital, Trieda SNP 1, Košice, SlovakiaMarián Benický, Department of pathology, L.Pasteur University Hospital, Trieda SNP 1, Košice, SlovakiaTomáš Torday, Department of pathology, L.Pasteur University Hospital, Trieda SNP 1, Košice, Slovakia Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5507285 Mon, 12 Dec 2011 17:14:28 +0100 5507285 http://www.medworm.com/index.php?rid=5496825&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq5653x467078h863%2F In conclusion, straightforward interpretation of clonality testing results can be hampered by the occurrence of multiple clonal products. Only careful consideration of immunobiological and technical explanations will prevent incorrect interpretation in such cases. Content Type Journal ArticleCategory ReviewPages 1-9DOI 10.1007/s12308-011-0129-1Authors Anton W. Langerak, Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The NetherlandsJacques J. M. van Dongen, Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5496825 Fri, 09 Dec 2011 17:05:59 +0100 5496825 http://www.medworm.com/index.php?rid=5496826&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg0847227333576n6%2F In conclusion, BIOMED-2 TCRγ and TCRβ assays show superior sensitivity for the detection of T cell clonality. However, the complexity of BIOMED-2 protocols requires stringent quality control and experience in interpreting GeneScan patterns. Content Type Journal ArticleCategory Original ArticlePages 1-10DOI 10.1007/s12308-011-0128-2Authors Irina Bonzheim, Institute of Pathology, University Hospital and Comprehensive Cancer Center Tübingen, Liebermeisterstr. 8, 72076 Tübingen, GermanyFlorian Fröhlich, Institute of Pathology, University Hospital and Comprehensive Cancer Center Tübingen, Liebermeisterstr. 8, 72076 Tübingen, GermanyPatrick Adam, Institute of Pathology, University Hospital and Comprehensive Cancer Center Tübingen, Liebermeisterstr. 8, 72076 Tübingen, GermanySem... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5496826 Fri, 09 Dec 2011 17:05:58 +0100 5496826 http://www.medworm.com/index.php?rid=5478725&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk326767m8111g83w%2F Content Type Journal ArticleCategory Case ReportPages 1-7DOI 10.1007/s12308-011-0124-6Authors Rebecca Sonu, Department of Pathology and Laboratory Medicine, University of California, Davis, Medical Center, PATH Bldg. 4400 V Street, Sacramento, CA 95817, USAJeffrey Gregg, Department of Pathology and Laboratory Medicine, University of California, Davis, Medical Center, PATH Bldg. 4400 V Street, Sacramento, CA 95817, USAMingyi Chen, Department of Pathology and Laboratory Medicine, University of California, Davis, Medical Center, PATH Bldg. 4400 V Street, Sacramento, CA 95817, USA Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5478725 Fri, 02 Dec 2011 06:48:16 +0100 5478725 http://www.medworm.com/index.php?rid=5470570&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F771268716414686q%2F Abstract  Clonality assessment is an established tool in the diagnosis of malignant lymphoma; however, the evaluation of immunoglobulin/T-cell receptor (Ig/TCR) gene rearrangement profiles is not always straightforward. Therefore, the EuroClonality group supports and advises diagnostic laboratories in their clonality assessments on samples from patients suspicious for lymphoma, who are seen in the routine diagnostic setting. The support for clonality assessment is provided via the EuroClonality website: http://www.euroclonality.org. The features and procedures of the website are presented in this paper. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s12308-011-0120-xAuthors Paul D. M. Rombout, Department of Pathology, Radboud University Nijmeg... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5470570 Wed, 30 Nov 2011 04:56:25 +0100 5470570 http://www.medworm.com/index.php?rid=5450935&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg51613w271w3xt03%2F Content Type Journal ArticleCategory EditorialPages 1-1DOI 10.1007/s12308-011-0122-8Authors J. Han van Krieken, Department of Pathology, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5450935 Thu, 24 Nov 2011 17:53:22 +0100 5450935 http://www.medworm.com/index.php?rid=5450936&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1m7860921j1m6736%2F Content Type Journal ArticleCategory Book ReviewPages 1-1DOI 10.1007/s12308-011-0121-9Authors J. Han van Krieken, Department of Pathology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 Nijmegen, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5450936 Thu, 24 Nov 2011 06:51:25 +0100 5450936 http://www.medworm.com/index.php?rid=5433479&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp00006829u511347%2F Abstract  The t(14;19)(q32;q13) is a rare cytogenetic abnormality that occurs in <0.1% of all B-cell neoplasms. The majority of these cases has been categorised as “atypical” chronic lymphocytic leukaemia (CLL). Although the clinical presentation is similar to CLL, these patients are often younger, with a stronger male predominance and the disease is reported to have a more aggressive clinical course. The peripheral blood/bone marrow aspirate morphology is “atypical”, but these differences are not recognised on bone marrow or lymph node histology. The immunoprofile is CD5 positive and usually CD23 dim/negative with a low Matutes CLL score. Fluorescence in situ hybridisation confirms the presence of the translocation giving rise to IGH/BCL3 fusion. Many cases also... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5433479 Fri, 18 Nov 2011 06:56:27 +0100 5433479 http://www.medworm.com/index.php?rid=5411594&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F842tw73811412313%2F Abstract  Clonality analysis is a critical tool for the diagnosis of suspect lymphoproliferative disorders. Amplification of the immunoglobulin and T cell receptor genes on genomic DNA from the suspect samples is followed by analysis of the PCR products to distinguish between polyclonal and clonal rearrangements. These analyses are based on electrophoresis in polyacrylamide gels after heteroduplex formation, or more frequently, GeneScan analysis is performed by capillary electrophoresis in automated DNA analysers, providing higher resolution and sensitivity. An alternative method for clonality analysis is the use of single-strand conformation analysis; however, this usually required labour intensive work with polyacrylamide gels and radioactive labelling. Within the EuroClon... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5411594 Mon, 14 Nov 2011 16:52:45 +0100 5411594 http://www.medworm.com/index.php?rid=5338851&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa44n7x7433602451%2F Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.1007/s12308-011-0118-4Authors Michael J. Rauh, Department of Pathology and Molecular Medicine, Richardson Laboratory, Queen’s University, 88 Stuart Street, Kingston, ON K7L 3N6, CanadaJane Liesveld, Department of Medicine, University of Rochester Medical Center, Rochester, USAW. Richard Burack, Department of Pathology, Hematopathology Section, the James P. Wilmot Cancer Center, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USAJohn M. Bennett, Department of Medicine, University of Rochester Medical Center, Rochester, USA Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5338851 Mon, 17 Oct 2011 16:03:58 +0100 5338851 http://www.medworm.com/index.php?rid=5317332&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv464rg1441v46704%2F This study adds to the morphologic spectrum of IgG4-related lymphadenopathy. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s12308-011-0117-5Authors Imran N. Siddiqi, Department of Pathology, University of Southern California Keck School of Medicine, 2011 Zonal Ave., HMR 209, Los Angeles, CA 90033, USARussell K. Brynes, Department of Pathology, University of Southern California Keck School of Medicine, 2011 Zonal Ave., HMR 209, Los Angeles, CA 90033, USAKate Grimm, Clarient Inc./GE Healthcare, Aliso Viejo, CA, USADennis P. O’Malley, Clarient Inc./GE Healthcare, Aliso Viejo, CA, USAEndi Wang, Department of Pathology, Duke University Medical Center, Durham, NC, USA Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopat... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5317332 Tue, 11 Oct 2011 15:53:21 +0100 5317332 http://www.medworm.com/index.php?rid=5276590&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnx2n3631wrlq0451%2F We describe a 55-year-old male who initially presented in March 2010 with significant ascites and extensive lymphadenopathy. A diagnosis of B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma, was made in both peritoneal fluid and bone marrow. The malignant cells expressed CD10, CD19, CD20, CD45 (bright), CD79b, and monotypic kappa light chain, but were negative for TdT. Both IGH/BCL2 and IGL/MYC gene rearrangements were identified by FISH. Following chemotherapy, the patient remained in morphologic and cytogenetic remission for approximately 4 months. At relapse, a precursor B-cell lymphoma was detected in the diaphragm, pleural wall, and pleural effusion. The malignant cells were TdT positive and were negative ... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5276590 Wed, 28 Sep 2011 05:51:16 +0100 5276590 http://www.medworm.com/index.php?rid=5276591&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwhh613j066r517w5%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s12308-011-0114-8Authors Michael Bellone, Department of Anatomic Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USAAnn-Leslie Zaslav, Cytogenetics, Department of Clinical Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USABonnie Kiner-Strachan, Department of Medicine, Bone Marrow Transplant Unit, Stony Brook University Medical Center, Stony Brook, NY 11794, USAMarc Golightly, Flow Cytometry, Department of Clinical Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USATheresa Mercado, Cytogenetics, Department of Clinical Pathology, Stony Brook University Medical Center, Stony Brook, NY 11794, USATahmeena Ahmed, Department of Anatomic Path... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5276591 Wed, 28 Sep 2011 05:51:15 +0100 5276591 http://www.medworm.com/index.php?rid=5228700&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb8285776336j69n1%2F Content Type Journal ArticleCategory Review of the LiteraturePages 135-144DOI 10.1007/s12308-011-0112-xAuthors J. Han van Krieken, Department of Pathology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 Journal Volume Volume 4 Journal Issue Volume 4, Number 3 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5228700 Tue, 13 Sep 2011 05:52:11 +0100 5228700 http://www.medworm.com/index.php?rid=5212531&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4833366x88888r1k%2F We report a case of parvovirus B19-associated chronic aplastic anaemia in a 34-year-old female patient who presented with gum bleeding and ecchymotic patches over both legs and curdy vaginal discharge. She had pancytopenia on peripheral blood film examination and was subjected to bone marrow biopsy as the marrow aspirate showed peripheral blood only hence was not conclusive. Bone marrow biopsy was reported as AA, severe grade. The serological analysis performed later on revealed parvovirus B19 infection. Acute infection with B19V should be considered as a cause of acquired aplastic anaemia in individuals where other etiological factors are not elucidated. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s12308-011-0113-9Authors Rajeev Sen, Department of Path... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5212531 Fri, 09 Sep 2011 05:49:08 +0100 5212531 http://www.medworm.com/index.php?rid=5212532&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0773g6588h776152%2F Content Type Journal ArticleCategory Book ReviewPages 1-1DOI 10.1007/s12308-011-0110-zAuthors Konnie Hebeda, Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5212532 Wed, 07 Sep 2011 15:48:47 +0100 5212532 http://www.medworm.com/index.php?rid=5212534&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F63316871576p2566%2F Content Type Journal ArticleCategory Book ReviewPages 1-2DOI 10.1007/s12308-011-0109-5Authors Han van Krieken, Department of Pathology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 Nijmegen, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5212534 Wed, 07 Sep 2011 15:48:46 +0100 5212534 http://www.medworm.com/index.php?rid=5212533&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff282kr86276t7x46%2F Content Type Journal ArticleCategory EditorialPages 1-1DOI 10.1007/s12308-011-0111-yAuthors J. Han van Krieken, Department of Pathology, Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5212533 Wed, 07 Sep 2011 15:48:46 +0100 5212533 http://www.medworm.com/index.php?rid=5186288&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp752t2473pp821px%2F In this study, we evaluated the presence of genetic abnormalities and (immunoglobulin heavy chain variable genes) IGHV use and mutation status in lymph node samples of patients presenting with lymphadenopathy alone and, therefore, classified as SLL (n = 21) or with persisting lymphadenopathy and absolute lymphocyte counts of ≥5 × 109/L and, therefore, classified as CLL/SLL (n = 17). In addition, blood samples of CLL patients were evaluated (n = 82). The majority of lymph node samples from SLL patients (66%) showed unmutated IGHV genes. This occurrence was significantly higher than in CLL (29%). Poor risk genetic aberrations (11q-, 17p-, and +12) were more prevalent in the SLL (45%) as compared to CLL (22%). Samples from CLL/SLL patients exhibited almost equal frequenc... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5186288 Wed, 31 Aug 2011 15:56:09 +0100 5186288 http://www.medworm.com/index.php?rid=5149086&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhr2036216hjk987v%2F We present a case of NLPHL arising in the tonsil of a 43-year-old man. The patient presented with a submucosal mass in an asymmetrically enlarged tonsil. Bilateral tonsillectomy was performed and histological examination showed effacement of the enlarged tonsil by nodules comprised of scattered large atypical cells having classic lymphocyte-predominant cell morphology in a background of benign B cells. Immunohistochemical analysis showed lack of CD15 and CD30 in the LP cells and strong expression of CD20, CD45, BCL-6 and epithelial membrane antigen (EMA). Interphase fluorescence in situ hybridization (FISH) analysis, revealed bcl-6 gene rearrangement in the LP cells. Although lymphoma is a common malignancy of the tonsil, there are only sporadic reports of NLPHL arising in this locat... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5149086 Wed, 17 Aug 2011 05:54:23 +0100 5149086 http://www.medworm.com/index.php?rid=5127744&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbn64u69x484ph157%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s12308-011-0107-7Authors Harry Zhang, Department of Pathology and Laboratory Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USAHossein Salimnia, Department of Pathology and Laboratory Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USAGail Bentley, Department of Pathology and Laboratory Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USAWeimin Liu, Department of Pathology and Laboratory Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USAMichele Phillips, Detroit Medical Center University Laboratories, Detroit Medical Center, Detroit, MI 48201, USAGerald L. Feldman, Department of Pathology and Laboratory Medicine, Wayne State University School... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5127744 Fri, 12 Aug 2011 06:15:13 +0100 5127744 http://www.medworm.com/index.php?rid=5099439&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fau2u84341347p561%2F Content Type Journal ArticlePages 1-5DOI 10.1007/s12308-011-0105-9Authors Changlee S. Pang, Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1072, USAMark J. Pettenati, Department of Medical Genetics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1072, USACyrus Manavi, Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1072, USAKenneth W. Zamkoff, Department of Hematology and Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1072, USA Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5099439 Tue, 02 Aug 2011 05:55:30 +0100 5099439 http://www.medworm.com/index.php?rid=5065421&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk272h43321857027%2F Abstract  Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a distinct neoplasm within the spectrum of Hodgkin lymphomas with characteristic clinical, morphological, and immunohistochemical features. According to the WHO definition, lymph nodes involved by NLPHL should have a nodular or nodular and diffuse proliferation of scattered large neoplastic lymphocyte-predominant (LP) cells in a small cell background that reside in expanded follicular dendritic cell meshworks; the LP cells must also have a distinct immunophenotypic profile. The LP cells are monoclonal B cells that are typically CD20, BCL6, CD79a, and CD45 positive and are CD30 and CD15 negative. In contrast, the Reed-Sternberg cells of classical Hodgkin lymphoma (CHL) are typically positive for CD15 and CD... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5065421 Sat, 23 Jul 2011 05:55:20 +0100 5065421 http://www.medworm.com/index.php?rid=5058662&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3647083027784t46%2F Content Type Journal ArticlePages 1-3DOI 10.1007/s12308-011-0103-yAuthors Kamraan Z. Gill, Departments of Pathology and Cell Biology, Columbia University Medical Center and New York Presbyterian Hospital, 630 W. 168 St., VC14-229, New York, NY 10032, USAShafinaz Hussein, Departments of Pathology and Cell Biology, Columbia University Medical Center and New York Presbyterian Hospital, 630 W. 168 St., VC14-229, New York, NY 10032, USAYuxia Jia, Division of Hematology/Oncology, Columbia University Medical Center and New York Presbyterian Hospital, New York, NY, USAVundavalli V. Murty, Departments of Pathology and Cell Biology, Columbia University Medical Center and New York Presbyterian Hospital, 630 W. 168 St., VC14-229, New York, NY 10032, USAGovind Bhagat, Departments of Pathology and C... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5058662 Thu, 21 Jul 2011 18:06:20 +0100 5058662 http://www.medworm.com/index.php?rid=5043095&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F26x76662r4122065%2F We report the case of an 88-year-old woman who initially presented with pain, swelling, and loss of vision in her left eye. A left orbital mass was revealed by computed tomography, and a biopsy was performed. On histologic examination, large atypical lymphoid cells were present in blood vessel lumina of the intraorbital adipose tissue. No tumor cells were seen in the surrounding tissue. By immunohistochemistry, the tumor cells were positive for CD20, BCL-2, Bcl-6, and CD5; they were negative for CD10 and cyclin D1. Ki-67 revealed a proliferation rate of approximately 80–90%, and CD31 highlighted the vascular endothelium. These findings confirmed the diagnosis of intravascular large B-cell lymphoma. Results of bone marrow and cerebrospinal fluid examinations were negative for involv... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5043095 Thu, 14 Jul 2011 06:00:43 +0100 5043095 http://www.medworm.com/index.php?rid=5012718&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe7628h8003q70268%2F Abstract  The term composite lymphoma defines a lymphoma consisting of two or more morphologically and immunophenotypically distinct lymphomas within the same lymph node or other organ. Recently, several molecular studies have shown that different components within a composite lymphoma may arise from a common clone. In contrast, there are also reports of biclonal cases of composite lymphoma. For this study, we identified five cases of composite lymphoma and analyzed them by various techniques to determine the clonality of the components. In four cases (1–4), a laser capture microdissection technique was used to collect separately each of the component lymphoma types. These were analyzed by polymerase chain reaction (PCR) to assess the rearrangement of the J segment of the... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=5012718 Fri, 08 Jul 2011 06:32:41 +0100 5012718 http://www.medworm.com/index.php?rid=4940476&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4n544536xn4h8w38%2F Abstract  Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a clinically aggressive hematologic malignancy derived from clonal proliferation of plasmacytoid dendritic cells. The disease has two patterns of presentation: cutaneous and leukemic. Herein we describe the case of a 9-year-old boy who presented with an unusual morphologic variant of leukemic BPDCN, showing bone marrow infiltration by medium to large cells with eccentric nuclei, regular round to oval shape, finely dispersed chromatin, one or more distinct nucleoli, and abundant basophilic cytoplasm, forming a pattern that resembled plasmablasts. Multiparameter flow cytometric immunophenotyping confirmed the diagnosis of BPDCN by identifying the expression of CD4++, CD56++, HLA-DR+++, and CD123+++ in abnormal c... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4940476 Fri, 10 Jun 2011 06:39:31 +0100 4940476 http://www.medworm.com/index.php?rid=4916099&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw14v48752n1366v8%2F Abstract  The best characterized primary splenic B-cell lymphoma/leukaemias include splenic marginal zone lymphoma (SMZL) and hairy cell leukaemia (HCL). However, there are other primary splenic B-cell neoplasms that do not have the characteristic features of SMZL or HCL. The WHO classification has proposed a provision entity—splenic B-cell lymphoma/leukaemia, unclassifiable (SBLLu) to include the better-defined small B-cell clonal lymphoproliferations involving spleen that do not fall into any of the other types of B-cell lymphoid neoplasms. The recognized provisional entities among SBLLu include splenic diffuse red pulp small B-cell lymphoma (SDRPSBL) and hairy cell leukaemia variant (HCLv). The possibility of SBLLu arises when the spleen shows diffuse red pulp involvem... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916099 Tue, 07 Jun 2011 15:51:24 +0100 4916099 http://www.medworm.com/index.php?rid=4916100&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn1337782m4j460k3%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s12308-011-0099-3 Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916100 Thu, 02 Jun 2011 05:59:52 +0100 4916100 http://www.medworm.com/index.php?rid=4916101&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh3131724r84m4176%2F In this report we present therapy-related T-lymphoblastic lymphoma following APL treatment. The bone marrow analysis showed MLL and MAML2 genes rearrangement that can explain the molecular basis for the lymphoma development. Content Type Journal ArticlePages 1-5DOI 10.1007/s12308-011-0100-1Authors Alireza Torabi, Department of Pathology and Laboratory Medicine, William Beaumont Hospital, Royal Oak, MI, USAMohammad M. Chisti, Department of Medical Oncology, William Beaumont Hospital, Royal Oak, MI, USAGovinda Brahmanday, Department of Medical Oncology, William Beaumont Hospital, Royal Oak, MI, USAVonda Douglas-Nikitin, Department of Pathology and Laboratory Medicine, William Beaumont Hospital, Royal Oak, MI, USAAlaa Muslimani, Department of Medical Oncology, William Beaumont Hospit... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916101 Wed, 01 Jun 2011 05:59:12 +0100 4916101 http://www.medworm.com/index.php?rid=4916102&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq41286301678636g%2F Abstract  Bcr-abl-negative myeloproliferative neoplasms (MPN), comprising polycythaemia vera (PV), primary myelofibrosis (PMF) and essential thrombocythaemia (ET), usually follow a biphasic course. From a phase which is characterized by excess production of mature haematopoietic cells of one or more lineages, many, but not all MPN, progress to haematopoietic insufficiency with cytopenia affecting two or three lineages. The latter may be the result of either fibrosis, blastic transformation or both. An intermediate stage of variable duration is called acceleration. Unlike bcr-abl-positive chronic myeloid leukaemia (CML), acceleration in MPN is not homogeneously defined. Long-lasting PV may progress to a PMF-like myelofibrosis, labelled spent phase. Less frequently, PV develo... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916102 Mon, 30 May 2011 16:43:25 +0100 4916102 http://www.medworm.com/index.php?rid=4916103&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4513774682mv2t65%2F Abstract  An increase in eosinophils, basophils, and/or mast cells in the bone marrow may pose considerable diagnostic problems for the hematopathologist. In a first step, it is crucial to classify these changes as either being reactive or neoplastic. A slight increase in eosinophils is often seen in reactive states of myeloid hyperplasia while an increase in basophils is usually indicative of a neoplastic hematologic disorder. Regarding mast cells, the presence of compact infiltrates is the major criterion for systemic mastocytosis whereas a diffuse interstitial increase is often encountered in reactive states of mast cell hyperplasia. When a neoplastic disorder is diagnosed, definitive classification depends on immunohistochemical, molecular, and cytogenetic markers. The ... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916103 Fri, 27 May 2011 18:15:09 +0100 4916103 http://www.medworm.com/index.php?rid=4916104&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg58802621062k88k%2F Abstract  On average, 30% of patients with myelodysplastic syndrome (MDS) develop overt acute myeloid leukemia (AML) during the course of the disease. There is a continuous search for the best model of individual risk assessment for MDS patients. In this review, we summarize current findings on factors that have been associated with increased risk of AML transformation. These include laboratory values such as high lactate dehydrogenase levels, complex karyotypes, numbers and aberrant immunophenotype of bone marrow blasts, bone marrow-related features such as numbers and distribution of CD34+ cells, and recently established molecular markers. A wide range of described molecular aberrations in MDS, including various gene mutations, chromosomal instability, short telomeres, hi... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916104 Wed, 25 May 2011 16:06:35 +0100 4916104 http://www.medworm.com/index.php?rid=4916105&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy4r2062618733171%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s12308-011-0095-7Authors Han van Krieken, Department of Pathology, Radboud University Nijimegen Medical Center, Postbus 9101, 6500 HB Nijimegen, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916105 Wed, 25 May 2011 16:06:33 +0100 4916105 http://www.medworm.com/index.php?rid=4916106&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F331513g187q75q11%2F Abstract  The skills required of a physician are akin to those of a detective, fictional or real. The diagnostic process is based on observation, deduction, and inference. We may thus see the hematopathologist as using the same skills as a detective. Sometimes, the hematopathologist is involved, usually inadvertently, in the detection of actual crime or other illicit activity. More often, the skills of a detective are being applied in the normal diagnostic process. Content Type Journal ArticlePages 1-4DOI 10.1007/s12308-011-0098-4Authors Barbara J. Bain, Department of Haematology, St Mary’s Hospital Campus of Imperial College Faculty of Medicine, St Mary’s Hospital, Praed Street, London, W2 1NY UK Journal Journal of HematopathologyPrint ISSN 1868-9256 (Source... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916106 Tue, 24 May 2011 16:04:32 +0100 4916106 http://www.medworm.com/index.php?rid=4916107&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh1n8045p3431u504%2F Abstract  Chronic myelogenous leukemia, BCR-ABL1+ (CML) is a myeloproliferative neoplasm defined by the presence of the BCR-ABL fusion gene and a t(9;22)(q34;q11) cytogenetic abnormality. Its natural history is that of inexorable progression to an acute leukemia (blast crisis) after a prolonged chronic phase. The recent development of imatinib and other inhibitors of BCR-ABL tyrosine kinase activity has dramatically altered the clinical course of CML, with long-term remissions in most patients treated early in the course of the disease. Monitoring of resistance to therapy and progression on therapy are critical in the current management of the disease. Problems facing the diagnostic pathologist in this “Age of Imatinib” include accurate diagnosis and determination of CML ... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916107 Fri, 20 May 2011 16:16:04 +0100 4916107 http://www.medworm.com/index.php?rid=4916108&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F81412v3418241105%2F We describe two cases of acute myeloid leukemia with an unusual histological pattern mimicking metastatic non-hematopoietic neoplasm, leading to diagnostic difficulties. Both patients presented with pancytopenia and absence of circulating blasts. Bone marrow aspirations were not successful. Bone marrow core biopsies contained neoplastic cells arranged in cohesive sheets or single file patterns with prominent myxoid stroma resembling metastatic carcinoma. The accompanying bone marrow touch imprints showed clusters of immature cells with monocytoid features. The cell lineage was further revealed by immunohistochemical analysis of bone marrow core biopsy sections. The neoplastic cells showed strong reactivity for myeloperoxidase, CD33, CD43, CD45, and CD68, indicating a myeloid cell ori... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916108 Mon, 16 May 2011 15:47:28 +0100 4916108 http://www.medworm.com/index.php?rid=4916109&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0j210205n5k26710%2F Abstract  Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with a varying clinical outcome; however, the pathogenic mechanisms involved in disease development have remained largely unknown. In recent years, novel biomarkers, such as certain recurrent genomic alterations and the immunoglobulin heavy variable gene mutational status, have significantly improved the subdivision of the disease along with the prognostic assessment of individual patients. Advanced molecular studies have also revealed important genetic/epigenetic events and potential susceptibility loci for CLL, as well as implicating antigens in CLL development. Furthermore, the presence of monoclonal B cell lymphocytosis (MBL) has been demonstrated to precede CLL and appears to be a pre-leukemic cond... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916109 Mon, 16 May 2011 15:47:27 +0100 4916109 http://www.medworm.com/index.php?rid=4916110&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft040027148t21194%2F Abstract  The inherited bone marrow failure syndromes are a diverse group of disorders characterized by BM failure usually in association with one or more somatic/physical abnormality. Over the last two decades, the genes responsible for many of these have been identified. The significant advances in their molecular basis have provided insights into several biological pathways, such as DNA repair and telomere maintenance, of importance in human physiology. They have also provided a link between the inherited and idiopathic forms of bone marrow failure syndromes; for example, some patients with idiopathic forms of aplastic anemia have mutations in genes first identified in the classic forms of dyskeratosis congenita. Clinical similarities (bone marrow failure, developmental ... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916110 Thu, 12 May 2011 16:45:38 +0100 4916110 http://www.medworm.com/index.php?rid=4916111&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg443767x822q6mr8%2F Abstract  Bone marrow involvement is assessed in lymphoma staging/restaging following treatment/relapse by a combination of an aspirate and trephine biopsy. Of 262 consecutive cases staged by aspirate and trephine, the aspirate yielded a diagnosis when a trephine did not in only 11.8%. Trephine biopsies were positive in 34.7% cases and equivocal/insufficient in 14.9%, while aspirates were positive in 11.1% cases and equivocal/insufficient in 21%. We suggest that in the majority of cases, it may be acceptable either to store an aspirate for reporting only if the trephine is inconclusive or to take a trephine biopsy without an aspirate. Content Type Journal ArticlePages 1-4DOI 10.1007/s12308-011-0087-7Authors Zanna J. Voysey, Oxford University Medical School, Oxford, UKE... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916111 Tue, 12 Apr 2011 21:37:16 +0100 4916111 http://www.medworm.com/index.php?rid=4916112&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F33104h36048488r0%2F Content Type Journal ArticlePages 31-43DOI 10.1007/s12308-011-0086-8Authors J. Han van Krieken, Department of Pathology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 Journal Volume Volume 4 Journal Issue Volume 4, Number 1 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916112 Wed, 02 Mar 2011 07:46:07 +0100 4916112 http://www.medworm.com/index.php?rid=4916113&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj30471q0778264w0%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s12308-011-0085-9Authors J. H. van Krieken, Department of Pathology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 Journal Volume Volume 4 Journal Issue Volume 4, Number 1 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916113 Wed, 02 Mar 2011 07:46:06 +0100 4916113 http://www.medworm.com/index.php?rid=4916114&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr627r80536802888%2F We present seven cases of mantle cell lymphoma with morphological features of marginal-zone lymphoma. Of particular interest, four of the patients had predominant involvement of the gastrointestinal tract. All cases displayed the translocation t(11;14)(q13;q32) and expressed cyclin D1. Cytogenetic analysis revealed trisomy 3 in one case and somatic hypermutation of immunoglobulin heavy genes could be demonstrated in two out of four cases. The latter features are reminiscent of marginal-zone lymphoma. The localization of these lymphomas mainly in the gastrointestinal tract and the higher exposure to antigens in this area may explain why this variant of mantle cell lymphoma harbours features of marginal-zone lymphoma. Content Type Journal ArticlePages 7-11DOI 10.1007/s12308-011-008... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916114 Wed, 02 Mar 2011 07:46:05 +0100 4916114 http://www.medworm.com/index.php?rid=4916115&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc72u676258418j74%2F Abstract  The 2008 WHO update of Classification of Tumours of Hematopoietic and Lymphoid Tissues revised the classification of immunodeficiency-associated lymphoproliferative disorders with the aim to better define these heterogeneous entities to better distinguish between reactive and neoplastic lesions, further refine some entities (plasmablastic lymphoma, monomorphic post-transplant lymphoproliferative disorders and other iatrogenic immunodeficiency-associated lymphoproliferative disorders), and introduce a new lymphoma entity (large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease). The purpose of this review is to highlight the changes in the 2008 WHO classification of immunodeficiency-associated lymphoproliferative disorders. Content Type ... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916115 Sat, 19 Feb 2011 07:05:31 +0100 4916115 http://www.medworm.com/index.php?rid=4916116&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F26v1442ruw7l1052%2F Abstract  Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening inflammatory syndrome characterized by reactive proliferation of histiocytes in hematopoietic tissues, with accompanying hemophagocytosis. A number of primary and secondary triggers have been identified, including some hematolymphoid neoplasms. We submit the case of an 11-year-old female who presented with HLH and met diagnostic criteria for juvenile myelomonocytic leukemia, which included the apparently non-recurrent clonal cytogenetic abnormality t(5;12)(q35;q24.1). The diagnosis was eventually revised to systemic anaplastic large cell lymphoma with cryptic NPM-ALK fusion. We review the previously reported cases of pediatric HLH triggered by systemic ALCL and find that the marked neutrophilia, monocy... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916116 Wed, 26 Jan 2011 19:39:58 +0100 4916116 http://www.medworm.com/index.php?rid=4916117&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn417308g61565544%2F Content Type Journal ArticlePages 167-174DOI 10.1007/s12308-010-0078-0Authors J. Han van Krieken, Department of Pathology, Radboud University Nijmegen, Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 Journal Volume Volume 3 Journal Issue Volume 3, Number 4 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916117 Tue, 30 Nov 2010 08:18:00 +0100 4916117 http://www.medworm.com/index.php?rid=4916118&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5385204322176678%2F Abstract  The 2010 has seen steady advances in bone marrow biopsy (BMB) pathology. The following publications are a personal selection of publications that advance the understanding of the pathobiology of the bone marrow and the interpretation of the BMB. Content Type Journal ArticlePages 129-136DOI 10.1007/s12308-010-0075-3Authors Jon van der Walt, Department of Histopathology, St Thomas’ Hospital, Westminster Bridge Road, London, SE1 7EH UK Journal Journal of HematopathologyPrint ISSN 1868-9256 Journal Volume Volume 3 Journal Issue Volume 3, Number 4 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916118 Tue, 30 Nov 2010 08:17:58 +0100 4916118 http://www.medworm.com/index.php?rid=4916119&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv83810h17q4xqr27%2F Content Type Journal ArticlePages 127-127DOI 10.1007/s12308-010-0081-5Authors J. Han van Krieken, Department of Pathology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 Journal Volume Volume 3 Journal Issue Volume 3, Number 4 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916119 Tue, 30 Nov 2010 08:17:57 +0100 4916119 http://www.medworm.com/index.php?rid=4916120&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn2xv525323k453j4%2F We report a case of ALCL (monomorphic PTLD) in a 45-year-old male lung transplant recipient. Within the first year post-transplant, the patient presented with sepsis and acalculous cholecystitis. The patient ultimately underwent an open cholecystectomy and was subsequently found to have ALCL of the gallbladder. Despite aggressive treatment of septic shock, renal failure, and coagulopathy, the patient died 5 days after presentation. Content Type Journal ArticlePages 17-20DOI 10.1007/s12308-010-0080-6Authors Elizabeth Ann Wey, Department of Pathology, University of Michigan, 1301 Catherine Road, Ann Arbor, MI 48109, USALauren B. Smith, Department of Pathology, University of Michigan, 1301 Catherine Road, Ann Arbor, MI 48109, USA Journal Journal of HematopathologyPrint I... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916120 Tue, 23 Nov 2010 18:17:17 +0100 4916120 http://www.medworm.com/index.php?rid=4916121&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe347m78671140117%2F Abstract  Flow cytometry is the most sensitive and specific diagnostic modality for paroxysmal nocturnal hemoglobinuria (PNH) clone assessment in PNH and other bone marrow failure states. A total of 101 samples included 23 PNH, 46 aplastic anemia (AA), seven myelodysplastic syndrome (MDS) cases, and 25 normal controls. Flow cytometry was performed using CD55, CD59, and stain–lyse–wash method, and the PNH clone size was correlated with the severity of disease. The PNH clone size on granulocytes in PNH patients varied from 7% to 97% detected with a sensitivity of 0.2% and correlated with the clone on monocytes (r = 0.563; p < 0.01). In PNH patients, a significant correlation was seen between PNH clone and the hemoglobin of patient (r = −0.523; p < 0.... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916121 Tue, 23 Nov 2010 07:08:49 +0100 4916121 http://www.medworm.com/index.php?rid=4916122&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff5177278n611171w%2F We present a case of intravascular extranodal NK/T-cell lymphoma (ENKTCL), nasal type, in a 37-year-old Hispanic man admitted for severe abdominal pain. Intraoperative evaluation revealed necrotic small bowel and multiple mesenteric venous thromboses. Initial histologic examination demonstrated classic changes of ischemic bowel without evidence of dense lymphoid infiltrates or other mass lesions. However closer review of the mesenteric vasculature exposed an angioinvasive and angiodestructive process comprised of lymphomatous cells which were positive by immunohistochemistry for CD2, CD3, CD8, BCL2, TIA-1, Granzyme B, and Epstein-Barr virus (EBV) EBER in situ hybridization. Although exceedingly rare, isolated intravascular ENKTCL, nasal type, may present without a mass; such lesions ... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916122 Mon, 22 Nov 2010 16:47:14 +0100 4916122 http://www.medworm.com/index.php?rid=4916123&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fuv0r0r642072326l%2F We report a case of CDA II diagnosed in a 48-year-old woman with a longstanding history of anemia of unknown etiology. Content Type Journal ArticlePages 149-153DOI 10.1007/s12308-010-0073-5Authors Bevan Tandon, Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E. Huron, Feinberg 7-209A, Chicago, IL 60611, USALoAnn C. Peterson, Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E. Huron, Feinberg 7-209A, Chicago, IL 60611, USAStephanie Norwood, Department of Pathology, Northwestern University Feinberg School of Medicine, 251 E. Huron, Feinberg 7-209A, Chicago, IL 60611, USAAnaadriana Zakarija, Division of Hematology/Oncology, Department of Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, I... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916123 Thu, 18 Nov 2010 17:57:15 +0100 4916123 http://www.medworm.com/index.php?rid=4916124&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk8560154w8436337%2F In this report we aim to add a description of the splenic histology, and extend our knowledge of HCLv. We describe one case of this entity for which a splenic histology was available. It fulfilled all the diagnostic criteria for HCLv, exhibiting a characteristic pattern of splenic infiltration, and responded favorably to treatment. The case described seems to fit well with HCLv where neither morphology nor immunophenotype bears any relation with hairy cell leukemia. Content Type Journal ArticlePages 13-16DOI 10.1007/s12308-010-0077-1Authors George Kanellis, Haematopathology Department, Evangelismos Hospital, Perikleus 11, 17343 Athens, GreeceLuis Garcia-Alonso, Department of Haematology, Hospital Universitario de Getafe, Madrid, SpainFrancisca I. Camacho, Department of Pathology... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916124 Thu, 18 Nov 2010 17:57:14 +0100 4916124 http://www.medworm.com/index.php?rid=4916125&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy7642510704242mj%2F Abstract  Three bone marrow trephine biopsies from two multiple myeloma patients were involved by a diffuse infiltrate of microvacuolated plasma cells with a variable number of signet ring cells, CD138, κ-light chains, and ubiquitin positive. The vacuoles remained clear on PAS and in May–Grünwald–Giemsa-stained bone marrow aspirates. Differential diagnosis on conventional stains included malignant epithelial and mesenchymal tumors, non-neoplastic histiocytes, and fixation artifacts. Electron microscopy revealed translucent vacuoles with no apparent membrane and a fuzzy internal surface occasionally merging with smaller membrane-delineated spaces filled with granular material, without communication with cisternae of rough endoplasmic reticulum. Rare multivesicular bodi... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916125 Tue, 16 Nov 2010 19:31:24 +0100 4916125 http://www.medworm.com/index.php?rid=4916126&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk741156v4l123042%2F Abstract  Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma (NHL), representing approximately 25–30% of newly diagnosed adult NHL in Western countries. CD5-positive DLBCL has been reported in 10% of cases in some series. DLBCL with cyclin D1 expression has also been reported in the literature. These cases may sometimes be confused with mantle cell lymphoma (MCL), especially blastoid variant MCL, morphologically and immunophenotypically. Herein, we present an unusual case of a 41-year-old female without significant medical history who presented with a right facial/parotid mass. Morphologically, the tumor showed a diffuse growth pattern of large lymphoid cells with vesicular nuclei, consistent with a DLBCL. Immunostains, however, show... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916126 Fri, 05 Nov 2010 11:06:53 +0100 4916126 http://www.medworm.com/index.php?rid=4916127&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F05vp002w647505h7%2F Content Type Journal ArticlePages 59-59DOI 10.1007/s12308-010-0071-7Authors Han van Krieken, Department of Pathology, Radboud University Nijmegen Medical Center, Postbus 9101, 6500 HB Nijmegen, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 Journal Volume Volume 3 Journal Issue Volume 3, Numbers 2-3 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916127 Tue, 05 Oct 2010 05:50:38 +0100 4916127 http://www.medworm.com/index.php?rid=4916128&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp5618682724x2u49%2F Content Type Journal ArticlePages 117-126DOI 10.1007/s12308-010-0069-1Authors J. Han van Krieken, Department of Pathology, Radboud University Nijmegen, Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 Journal Volume Volume 3 Journal Issue Volume 3, Numbers 2-3 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916128 Tue, 05 Oct 2010 05:50:37 +0100 4916128 http://www.medworm.com/index.php?rid=4916129&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0132x77580461155%2F Abstract  Abnormalities of the TP53 gene in chronic lymphocytic leukaemia (CLL) are associated with large cell transformation, short survival and resistance to purine analogue therapy. Deletion of one allele and somatic mutation of the remaining allele have been described as the main mechanism of TP53 inactivation in CLL, but its relationship with p53 protein expression remains unclear. We studied 103 CLL patients using fluorescence in situ hybridisation (FISH) to detect allelic loss at chromosome 17p and immunohistochemistry (IHC) to test for p53 protein overexpression. TP53 deletion (≥10% of cells) was found in 21 cases (20.4%) and no deletion in 82 (79.6%). By IHC, 16 cases (15.5%) showed p53 protein expression and 87 (84.5%) were negative. There was a good correlation ... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916129 Mon, 04 Oct 2010 13:19:44 +0100 4916129 http://www.medworm.com/index.php?rid=4916130&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5821787714733108%2F We report the case of a 59-year-old woman who presented with a 6-cm mass in the liver. Histological examination showed spindle cells with a storiform pattern and prominent inflammatory infiltrate mimicking inflammatory pseudotumor. Spindle cells expressed follicular dendritic cell markers CD21 and CD35, and were positive for Epstein–Barr virus-encoded RNA and LMP-1 protein. In addition, neoplastic cells expressed estrogen receptor (ER). Fifteen cases of inflammatory pseudotumor-like follicular dendritic cell tumor of the liver including the case we describe here have been reported in the literature. A review of the literature disclosed that normal follicular dendritic cells may express ER; however, extensive testing has not been previously reported in follicular dendritic cell sarc... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916130 Mon, 27 Sep 2010 16:53:00 +0100 4916130 http://www.medworm.com/index.php?rid=4916131&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv2452746t88lvv54%2F Content Type Journal ArticlePages 101-107DOI 10.1007/s12308-010-0066-4Authors Elizabeth Kehr, Department of Pathology, Oregon Health & Science University, L-471, 3181 Sam Jackson Park Road, Portland, OR 97239-3098, USAPeter Stenzel, Department of Pathology, Oregon Health & Science University, L-471, 3181 Sam Jackson Park Road, Portland, OR 97239-3098, USAGang Xu, Department of Pathology, Oregon Health & Science University, L-471, 3181 Sam Jackson Park Road, Portland, OR 97239-3098, USAKatalin Kelemen, Department of Pathology, Oregon Health & Science University, L-471, 3181 Sam Jackson Park Road, Portland, OR 97239-3098, USA Journal Journal of HematopathologyPrint ISSN 1868-9256 Journal Volume Volume 3 Journal Issue Volume 3, Numbers 2-3 (Source: Journal of Hematopatholog... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916131 Tue, 21 Sep 2010 04:11:06 +0100 4916131 http://www.medworm.com/index.php?rid=4916132&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkr10pk36076g3720%2F We describe an unusual case of high-grade T cell lymphoma, presenting as rapidly enlarging, painless lymphadenopathy in an 80-year-old female. She died 13 months after presentation, having relapsed after chemotherapy. The lymph node showed diffuse effacement by blastic lymphoid cells, positive for T cell markers and cyclin D1. Molecular genetics investigations found t(11:14) translocation. There was definite T cell clonality demonstrating clonal rearrangement of both T cell receptor gamma and beta genes but no convincing evidence of B cell clonality. These data represent the first documented case where deregulation of the cyclin D1 expression has been implicated in human T cell lymphoreticular malignancy. Content Type Journal ArticlePages 77-81DOI 10.1007/s12308-010-0063-7Au... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916132 Fri, 16 Jul 2010 19:48:35 +0100 4916132 http://www.medworm.com/index.php?rid=4916133&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff07141j8rv258772%2F We report the case of an 86-year-old female who presented with lymphadenopathy, lymphocytosis, and thrombocytopenia. Peripheral blood immunophenotypic analysis identified two lymphoid B cell populations that differ in CD23, CD200, and CD43 expression and in the intensity of CD5, CD20, CD79b, and kappa light chain. By fluorescence in situ hybridization (FISH) analysis, approximately 30% of the mononuclear cells were positive for the t(11;14)(q13;q32) and 40% for trisomy 12; analysis of the two populations separated by fluorescence activated cell sorting showed that t(11;14) occurs exclusively in CD23−/CD200−/CD43− cells and trisomy 12 in the CD23+/CD200+/CD43+ population. Lymph node biopsy showed a typical small lymphocytic lymphoma morphology, with an effaced architecture and a... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916133 Tue, 06 Jul 2010 17:07:39 +0100 4916133 http://www.medworm.com/index.php?rid=4916134&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq171514027g26r2q%2F We report a case of EBV-positive diffuse large B-cell lymphoma (DLBCL) of the elderly with aberrant expression of TIA-1. The patient was an 84-year-old man with a history of progressively enlarged left parotid mass and mild facial paresis for 2 months. The incisional biopsy revealed sheets of medium to large lymphoma cells with focal angiocentricity and extensive tumor necrosis; only a few scattered small lymphocytes were noted among the lymphoma cells. Immunohistochemistry in formalin-fixed paraffin-embedded tissue demonstrated that the lymphoma cells marked with CD20, CD30, CD45 (focal), CD79a, BCL2 (focal and weak), PAX5, Oct2, BOB.1, IRF4/MUM1, EBV-LMP1, and TIA-1, but they did not mark with CD3, CD4, CD5, CD7, CD8, CD10, CD15, CD23, CD56, CD57, CD138, kappa and lambda immun... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916134 Mon, 28 Jun 2010 17:01:16 +0100 4916134 http://www.medworm.com/index.php?rid=4916135&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp10860h635742872%2F We report the clinical, histopathologic, and molecular features of a 6-year-old child who presented with EBV-positive Hodgkin lymphoma (HL), which led to the diagnosis of ataxia telangiectasia. The diagnosis of HL at this unusually young age prompted further clinical, immunologic and cytogenetic evaluations, all of which supported a diagnosis of A-T. Because A-T patients are exquisitely sensitive to radiation, the patient was put on a modified chemotherapeutic regimen; however, 14 months later, he experienced a relapse and passed away by age 9. Classical HL is relatively rare among A-T patients, and this is the first documented case of an EBER-1 positive Hodgkin lymphoma in an ataxia telangiectasia patient. A review of the literature examining cases of HL in A-T is provided. ... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916135 Wed, 16 Jun 2010 07:19:51 +0100 4916135 http://www.medworm.com/index.php?rid=4916136&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fct642jm355077570%2F Content Type Journal ArticlePages 47-58DOI 10.1007/s12308-010-0060-xAuthors J. Han van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 Journal Volume Volume 3 Journal Issue Volume 3, Number 1 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916136 Wed, 02 Jun 2010 14:10:13 +0100 4916136 http://www.medworm.com/index.php?rid=4916137&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F71l83r577w6hv726%2F Abstract  Fifty-five consecutive cases of Hodgkin’s lymphoma (HL), collected between 1996 and 1998 from Cairo, Egypt, were histologically subtyped, phenotyped, and then studied for the presence of Epstein–Barr virus (EBV). We used immunohistochemical stains for EBV latent membrane protein 1 (LMP-1) and in situ hybridization stains for EBV-encoded small RNA (EBER-1) transcripts. Forty-five cases (82%) had classic HL (cHL), and ten cases (18%) had nodular lymphocyte predominant HL (NLPHL), with each group expressing its typical phenotype. LMP-1 stains were positive in 63% and 0% of cHL and NLPHL cases, respectively. EBER-positive Reed–Sternberg cells and variants were also present in 62% and 0% of each group, respectively. The cHL cases showed variable EBER positivity: ... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916137 Thu, 27 May 2010 16:58:16 +0100 4916137 http://www.medworm.com/index.php?rid=4916138&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc7338h6565217521%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s12308-010-0061-9Authors J. Han van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 Journal Volume Volume 3 Journal Issue Volume 3, Number 1 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916138 Wed, 19 May 2010 11:23:59 +0100 4916138 http://www.medworm.com/index.php?rid=4916139&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff17t21u45qk11751%2F We present an unusual case that was caused by a diffuse infiltration of the myocardium with leukemic cells (myeloid sarcoma). The patient presented with episodic shortness of breath, he was anemic and thrombocytopenic, and his bone marrow biopsy revealed myelodysplastic syndrome from treatment for oligodendroglioma. His clinical course was characterized by a chronic leak of cardiac enzymes, a new right bundle branch block, and a large pericardial effusion causing tamponade and death from fulminant heart failure and ventricular arrhythmias within 2 weeks. At autopsy, the heart was massively infiltrated with myeloblasts and other immature myeloid cells. There was no evidence of acute leukemia in the bone marrow or peripheral blood. Cardiac infiltration in a patient with myelodyspl... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916139 Wed, 05 May 2010 07:59:10 +0100 4916139 http://www.medworm.com/index.php?rid=4916141&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp51766t2204p3106%2F We describe the unusual case of a 41-year-old male with NK cell lymphoma, nasal type, who presented with massive secondary lung involvement 2.5 years after the detection of a retroperitoneal mass. The diagnosis was made by open lung biopsy. Despite aggressive treatment, the patient died shortly after the initiation of therapy. Lung involvement by NK/T cell lymphoma occurs most commonly as part of widely disseminated disease and carries a poor prognosis for the patient. Novel agents and innovative therapies need to be developed for this aggressive lymphoma. Content Type Journal ArticlePages 19-22DOI 10.1007/s12308-009-0050-zAuthors Anamarija Morovic, University of Cincinnati College of Medicine Department of Pathology and Laboratory Medicine 231 Albert Sabin Way Cincinnati O... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916141 Tue, 23 Mar 2010 18:08:57 +0100 4916141 http://www.medworm.com/index.php?rid=4916140&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg7665p65t4426558%2F Abstract  Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), accounts for ∼5% of all cases of Hodgkin lymphoma and is characterized by involvement of the peripheral lymph nodes. NLPHL occurs in young adults and is associated with frequent relapses. In 3% to 7% of cases, NLPHL progresses to a diffuse large B cell lymphoma. Furthermore, a proportion of NLPHL also have areas with features of T cell/histiocyte-rich large B cell lymphoma (THRLBCL), either at presentation or on follow-up. Here, we describe a 32-year-old man who presented to the emergency department with small bowel perforation. The resected small bowel showed full-thickness mural ulceration and involvement by a lymphoma with features of NLPHL that also had areas resembling THRLBCL. The patient had axillar... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916140 Tue, 23 Mar 2010 18:08:57 +0100 4916140 http://www.medworm.com/index.php?rid=3401400&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2Fp51766t2204p3106%2F We describe the unusual case of a 41-year-old male with NK cell lymphoma, nasal type, who presented with massive secondary lung involvement 2.5 years after the detection of a retroperitoneal mass. The diagnosis was made by open lung biopsy. Despite aggressive treatment, the patient died shortly after the initiation of therapy. Lung involvement by NK/T cell lymphoma occurs most commonly as part of widely disseminated disease and carries a poor prognosis for the patient. Novel agents and innovative therapies need to be developed for this aggressive lymphoma. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12308-009-0050-zAuthors Anamarija Morovic, University of Cincinnati College of Medicine Department of Pathology and Laboratory Medicine 231 Albert Sabin Way Cin... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=3401400 Tue, 23 Mar 2010 18:08:57 +0100 3401400 http://www.medworm.com/index.php?rid=3401399&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2Fg7665p65t4426558%2F Abstract  Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), accounts for ∼5% of all cases of Hodgkin lymphoma and is characterized by involvement of the peripheral lymph nodes. NLPHL occurs in young adults and is associated with frequent relapses. In 3% to 7% of cases, NLPHL progresses to a diffuse large B cell lymphoma. Furthermore, a proportion of NLPHL also have areas with features of T cell/histiocyte-rich large B cell lymphoma (THRLBCL), either at presentation or on follow-up. Here, we describe a 32-year-old man who presented to the emergency department with small bowel perforation. The resected small bowel showed full-thickness mural ulceration and involvement by a lymphoma with features of NLPHL that also had areas resembling THRLBCL. The patient had axillar... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=3401399 Tue, 23 Mar 2010 18:08:57 +0100 3401399 http://www.medworm.com/index.php?rid=4916142&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu1543h2536641534%2F Abstract  NK/T lymphomas have rarely been reported in HIV/AIDS patients. Here we report a case of a 37-year-old woman, with AIDS and a recent diagnosis of Kaposi sarcoma in a mesenteric lymph node, who presented with extra-ocular nerve palsies and gastrointestinal bleeding. A small intestine resection specimen revealed an extra-nodal NK/T cell lymphoma, nasal type. The unique presentation of this rare and aggressive lymphoma in the setting of AIDS and Kaposi sarcoma underscores the importance of maintaining a broad differential diagnosis when evaluating a malignant neoplasm from a HIV-positive patient. Content Type Journal ArticlePages 35-40DOI 10.1007/s12308-010-0057-5Authors Nicole C. Panarelli, Weill Cornell Medical College Department of Pathology and Laboratory Med... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916142 Wed, 10 Mar 2010 16:08:50 +0100 4916142 http://www.medworm.com/index.php?rid=4916143&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb414454583064623%2F Abstract  In this paper, we describe a case of nodular lymphocyte predominant Hodgkin lymphoma with the subsequent development of a peripheral T cell lymphoma. This case is unusual in that the sheets of atypical and small to intermediate-sized T cells in the diffuse component were CD8 positive and expressed cytotoxic proteins. The diagnosis of peripheral T cell lymphoma was supported by the demonstration of a clonal T cell receptor beta chain gene rearrangement by Southern blot analysis. Peripheral T cell lymphoma with a cytotoxic phenotype is a rare entity with an aggressive clinical behavior. As such, this report emphasizes the need to consider a diagnosis of coexisting peripheral T cell lymphoma in cases of nodular lymphocyte predominant Hodgkin lymphoma with atypical fe... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916143 Wed, 10 Mar 2010 16:08:49 +0100 4916143 http://www.medworm.com/index.php?rid=4916144&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn32523266177080t%2F Abstract  Survivin is a member of the inhibitor of apoptosis gene family, which is also implicated in mitosis regulation. Most reports in the literature impute poor prognosis to neoplasms with overexpression of this protein. The purpose of the present study is to validate and compare the immunohistochemical reactivity of malignant lymphomas and reactive lymphoid tissue using a new mouse monoclonal antibody to Survivin produced in our laboratory, 6-78. Survivin was detected by immunohistochemistry on tissue microarrays. It was shown that the antibody anti-Survivin 6-78 reliably stains formalin-fixed, paraffin-embedded reactive and neoplastic lymphoid tissues, mostly in a nuclear pattern. We confirmed using this novel antibody that Survivin immunostaining has a tendency to be... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916144 Sat, 30 Jan 2010 18:16:30 +0100 4916144 http://www.medworm.com/index.php?rid=4916145&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5h78192g55q32315%2F Abstract  The term “gray-zone” lymphoma has been used to denote a group of lymphomas with overlapping histological, biological, and clinical features between various types of lymphomas. It has been used in the context of Hodgkin lymphomas (HL) and non-Hodgkin lymphomas (NHL), including classical HL (CHL), and primary mediastinal large B cell lymphoma, cases with overlapping features between nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte-rich large B cell lymphoma, CHL, and Epstein–Barr-virus-positive lymphoproliferative disorders, and peripheral T cell lymphomas simulating CHL. A second group of gray-zone lymphomas includes B cell NHL with intermediate features between diffuse large B cell lymphoma and classical Burkitt lymphoma. In order to revi... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916145 Mon, 21 Dec 2009 23:05:38 +0100 4916145 http://www.medworm.com/index.php?rid=4916146&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1u3lj01227574262%2F Content Type Journal ArticlePages 185-185DOI 10.1007/s12308-009-0051-yAuthors J. Han van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 Journal Volume Volume 2 Journal Issue Volume 2, Number 4 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916146 Fri, 18 Dec 2009 16:30:49 +0100 4916146 http://www.medworm.com/index.php?rid=4916147&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftg2464376w035279%2F Content Type Journal ArticlePages 245-251DOI 10.1007/s12308-009-0052-xAuthors J. Han van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1868-9256 Journal Volume Volume 2 Journal Issue Volume 2, Number 4 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916147 Thu, 17 Dec 2009 07:08:26 +0100 4916147 http://www.medworm.com/index.php?rid=4916148&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F527t575158m982u5%2F In conclusion, there is constitutive expression and activation of p38 MAPK in a large number of B-lymphoma-derived cell lines and primary lymphoma tissues, supportive of its role in lymphomagenesis. The differential IL-4 regulation of p38 MAPK expression in cell lines derived from DLBCL may relate to the cellular origin of these neoplasms. Content Type Journal ArticlePages 195-204DOI 10.1007/s12308-009-0049-5Authors Hu Ding, University of Utah Health Sciences Center Salt Lake City UT USAAli M. Gabali, University of Michigan Department of Pathology 4061 BSRB, 109 Zina Pitcher Place Ann Arbor MI 48109 USAStephen D. Jenson, University of Utah Health Sciences Center Salt Lake City UT USAMegan S. Lim, University of Michigan Department of Pathology 4061 BSRB, 109 Zina Pitcher Place Ann Ar... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=4916148 Wed, 21 Oct 2009 09:06:27 +0100 4916148 http://www.medworm.com/index.php?rid=2849117&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2F101218846q6574j1%2F Abstract  The purpose of this overview is to discuss the changes in the 2008 WHO classification of myeloid neoplasms, with exclusion of acute myeloid leukaemia. Specific mutations or rearrangements leading to constitutive activation of growth factor receptors or cytoplasmic tyrosine kinases are now recognised as recurrent genetic events characterising the group of myeloproliferative neoplasms (MPN). A newly introduced subgroup consists of patients with persistent eosinophilia and myeloid or lymphoid proliferations harbouring specific genetic changes involving platelet-derived growth factor receptors alpha and beta (PDGFRA and PDGFRB) or fibroblast growth factor receptor 1 (FGFR1). The clinical relevance of recognising myeloid neoplasms with aberrant tyrosine kinase activity i... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2849117 Mon, 28 Sep 2009 14:58:13 +0100 2849117 http://www.medworm.com/index.php?rid=2849118&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2Fg9tt8623804r0241%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s12308-009-0047-7Authors J. Han van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2849118 Mon, 28 Sep 2009 14:58:11 +0100 2849118 http://www.medworm.com/index.php?rid=2849119&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2F048480266w166481%2F Abstract  The second quarter of 2009 saw steady advances in bone marrow biopsy (BMB) pathology. The following publications are a personal selection of the highlights. Quality issues in diagnostic immunohistochemistry for BMB have largely been ignored in external quality assurance programmes, and this issue is highlighted. In other areas, publications reflecting advances in flow cytometry and aspirate morphology are discussed where translation to the BMB is possible. Classifications undergo constant change, and several publications address the redefinition of the cut off points between malignancy, benign, and normal. Lastly, current scientific research is presented where it is relevant to the understanding of BMB pathobiology. Content Type Journal ArticleCategory Review Ar... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2849119 Mon, 28 Sep 2009 14:58:10 +0100 2849119 http://www.medworm.com/index.php?rid=2849120&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2Fp67u9725vj10x852%2F Content Type Journal ArticleCategory Review of the LiteratureDOI 10.1007/s12308-009-0046-8Authors J. Han van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2849120 Mon, 28 Sep 2009 14:58:07 +0100 2849120 http://www.medworm.com/index.php?rid=2767741&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2Fv4121710206541hn%2F Abstract  We analyzed morphological and immunohistochemical features in 174 aggressive B-cell lymphomas of nodal and extranodal origin. Morphological features included presence or absence of a follicular component and cytologic criteria according to the Kiel classification, whereas immunohistochemical studies included expression of CD10, BCL-2, BCL-6, IRF4/MUM1, HLA-DR, p53, Ki-67 and the assessment of plasmacytoid differentiation. Patients were treated with a CHOP-like regimen. While the presence or absence of either CD10, BCL-6 and IRF4/MUM1 reactivity or plasmacytoid differentiation did not identify particular cytomorphologic or site-specific subtypes, we found that expression of CD10 and BCL-6, and a low reactivity for IRF4/MUM1 were favourable prognostic indicators. In... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2767741 Thu, 03 Sep 2009 05:59:31 +0100 2767741 http://www.medworm.com/index.php?rid=2722239&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2Fg274195p18396272%2F We describe two cases of lymphoid malignancies predominantly involving the breast, both presenting diagnostic dilemmas. The first case, ALK-negative anaplastic large-cell lymphoma involving a seroma associated with a breast implant, is an emerging clinicopathologic entity. Anaplastic large-cell lymphoma has been identified in association with breast implants and seroma formation relatively recently. The second case, hairy cell leukemia involving the breast and ipsilateral axillary sentinel lymph node, is, to our knowledge, the first reported case of hairy cell leukemia involving the breast at the time of diagnosis. While a localized bone lesion was present at time of diagnosis, bone marrow involvement was relatively mild in comparison to that seen in the breast and lymph node. In the... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2722239 Thu, 20 Aug 2009 08:31:19 +0100 2722239 http://www.medworm.com/index.php?rid=2661767&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2Fd833tv4285002322%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s12308-009-0042-zAuthors J. H. van Krieken, Radboud University Nijmegen Medical Centre Department of Pathology P.O. Box 9101 6500 HB Nijmegen The Netherlands Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2661767 Thu, 30 Jul 2009 18:47:36 +0100 2661767 http://www.medworm.com/index.php?rid=2661768&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2Fl3651n7vwv50927q%2F We report the case of a patient who showed the sequential occurrence of four different lymphoid neoplasms together with a squamous cell carcinoma of the lung. A 62-year-old man with adenopathy was admitted to the hospital, and lymph node biopsy was positive for low-grade follicular lymphoma. He achieved a partial remission with chemotherapy. Two years later, a PET-CT scan showed a left hilar mass in the lung; biopsy showed a squamous cell carcinoma. Simultaneously, he was diagnosed with diffuse large B cell lymphoma in a neck lymph node; after chemo- and radiotherapy, he achieved a complete response. A restaging PET-CT scan 2 years later revealed a retroperitoneal nodule, and biopsy again showed a low-grade follicular lymphoma, while a biopsy of a cutaneous scalp lesion showed a... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2661768 Thu, 30 Jul 2009 18:47:33 +0100 2661768 http://www.medworm.com/index.php?rid=2661769&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2Fc2u35532j3kv1437%2F Content Type Journal ArticleCategory CommentDOI 10.1007/s12308-009-0035-yAuthors Megan S. Lim, University of Michigan Medical School Department of Pathology M5242D, Med Sci I, 1301 Catherine Road Ann Arbor MI 48109 USA Journal Journal of HematopathologyPrint ISSN 1865-5785 (Source: Journal of Hematopathology) Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2661769 Thu, 30 Jul 2009 18:47:32 +0100 2661769 http://www.medworm.com/index.php?rid=2592515&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2Fm664411631245260%2F This study confirmed findings from wealthy countries that a specialised haematopathology service can improve LPD diagnosis. This model of Ghana–UK collaboration provides a platform on which to build local capacity to operate an international quality diagnostic service for LPDs. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s12308-009-0032-1Authors Elizabeth Parkins, Royal Cornwall Hospital Trust Truro TR1 3LJ UKRoger G. Owen, St James’s Institute of Oncology HMDS Laboratory Beckett Street Leeds LS9 7TF UKGeorge Bedu-Addo, Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital and School of Medical Sciences P. O. Box 1934 Kumasi GhanaOhene Opare Sem, Kwame Nkrumah University of Science and Technology Komfo Anokye Teaching Hospital an... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2592515 Thu, 09 Jul 2009 12:17:09 +0100 2592515 http://www.medworm.com/index.php?rid=2566086&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2Fm89474834v694795%2F Abstract  A case of primary myelofibrosis involving lymph node and with a novel cytogenetic abnormality [del (18) (p11.2-3)] is reported. The abnormalities are identical among specimens from the lymph node, peripheral blood, and bone marrow that were analyzed years apart. Additionally, we show that the infiltrate by dysplastic megakaryocytes in the lymph node morphologically mimics a metastatic mesenchymal neoplasm, even when the clinical history myelofibrosis was known. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12308-009-0040-1Authors Youjun Hu, Stony Brook University Hospital Department of Pathology Stony Brook NY 11794 USAAnn-Leslie Zaslav, Stony Brook University Hospital Department of Pathology Stony Brook NY 11794 USANeetu Radhakrishnan, Stony Broo... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2566086 Tue, 30 Jun 2009 15:41:38 +0100 2566086 http://www.medworm.com/index.php?rid=2558542&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2Fj473485p1425xp67%2F Abstract  In 2008, the World Health Organization (WHO) published a revised and updated edition of the classification of tumors of the hematopoietic and lymphoid tissues. The aims of the fourth edition of the WHO classification was to incorporate new scientific and clinical information in order to refine diagnostic criteria for previously described neoplasms and to introduce newly recognized disease entities. The recognition that T-cell lymphomas are related to the innate and adaptive immune system, as well as enhanced understanding of other T-cell subsets, such as the regulatory T-cell and follicular helper T-cells, has contributed to our understanding of the morphologic, histologic, and immunophenotypic features of T- and NK-cell neoplasms. The purpose of this review is to... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2558542 Mon, 29 Jun 2009 10:30:36 +0100 2558542 http://www.medworm.com/index.php?rid=2558543&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2F2k0810314201tg68%2F Abstract  The 2008 WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues has introduced two new categories of high-grade B-cell lymphomas: entities in which features of diffuse large B-cell lymphoma (DLBCL) overlap with Burkitt lymphoma (DLBCL/BL) or classical Hodgkin lymphoma (DLBCL/HL). The DLBCL/BL category encompasses cases that resemble Burkitt lymphoma morphologically, but have one or more immunophenotypic or molecular genetic deviations that would exclude it from the BL category; conversely, some cases have immunophenotypic and/or genetic features of BL, but display cytologic variability unacceptable for BL. Many of the cases in the DLBCL/BL category contain a translocation of MYC as well as either BCL2 or BCL6 (so-called double-hit lymphomas) and have a... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2558543 Mon, 29 Jun 2009 10:30:30 +0100 2558543 http://www.medworm.com/index.php?rid=2549757&cid=s_37296_32_f&fid=37296&url=http%3A%2F%2Fspringerlink.com%2Fcontent%2Fr1k2073k301j6h1h%2F Abstract  The 4th edition of the World Health Organization classification of tumors of hematopoietic and lymphoid tissues introduces many new items to the classification scheme of the so-called indolent B cell lymphomas. New proposed entities, such as splenic B cell lymphoma/leukemia, unclassifiable, splenic diffuse red pulp small B cell lymphoma, hairy cell leukemia variant, pediatric follicular lymphoma, and pediatric marginal zone lymphoma have been coined, and some definitions of established diseases, such as chronic lymphocytic leukemia or Waldenström’s macroglobulinemia have been revised. One aspect of major importance is the recent description of small clonal B cell populations, in part with a CLL phenotype, and their relationship to B-CLL. Some new subtypes or vari... Journal of Hematopathology journals http://www.medworm.com/rss/comments.php?id=2549757 Thu, 25 Jun 2009 06:54:35 +0100 2549757