Journal of Hepatology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Hepatology' source. Wed, 08 Feb 2012 16:28:24 +0100 Contents http://www.medworm.com/index.php?rid=5598711&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811007495%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598711 Tue, 17 Jan 2012 22:04:56 +0100 5598711 Short-Term Fellowship http://www.medworm.com/index.php?rid=5598710&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811007471%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598710 Tue, 17 Jan 2012 22:04:56 +0100 5598710 Clinical School of Hepatology Bologna http://www.medworm.com/index.php?rid=5598709&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS016882781100746X%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598709 Tue, 17 Jan 2012 22:04:56 +0100 5598709 ILC Barcelona 2012 http://www.medworm.com/index.php?rid=5598708&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811007458%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598708 Tue, 17 Jan 2012 22:04:56 +0100 5598708 EASL Monothematic Tallin, Estonia http://www.medworm.com/index.php?rid=5598707&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811007446%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598707 Tue, 17 Jan 2012 22:04:56 +0100 5598707 Editorial Board http://www.medworm.com/index.php?rid=5598706&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811007434%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598706 Tue, 17 Jan 2012 22:04:56 +0100 5598706 Guide for authors http://www.medworm.com/index.php?rid=5505983&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006969%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505983 Fri, 16 Dec 2011 09:35:54 +0100 5505983 Betablockers induce cardiac chronotropic incompetence http://www.medworm.com/index.php?rid=5505979&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006489%2Fabstract%3Frss%3Dyes We read with great interest the paper by Sersté et al. regarding effects of non-selective beta-blockers (BB) and paracentesis induced circulatory dysfunction (PICD) . This is the first study to explore the background for potential deleterious effects of BB in refractory ascites, as suggested in a previous study by the authors . The high risk of PICD after BB treatment seems related to an inability to increase heart rate during a circulatory challenge. BB bind to β1 and β2-adrenoreceptors and thereby compete with the binding of norepinephrine (NE) and epinephrine. Blocking the β1 receptors reduces the heart rate as well as inotropy and hence the cardiac output even in decompensated patients . (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505979 Fri, 16 Dec 2011 09:35:54 +0100 5505979 Get Active http://www.medworm.com/index.php?rid=5505933&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006842%2Fabstract%3Frss%3Dyes January is traditionally a time for making (and breaking) New Year’s resolutions. If your resolution is anything like mine it could probably be summed up as eating less and exercising more than the patients in my NAFLD clinic. Perhaps I could help you to find a more original resolution for 2012 – Get Active. No, I don’t mean get physically active, I mean get politically active. The Hepatology community is very effective when it comes to clinical care and research excellence but I do not feel that we match up to other specialties when it comes to lobbying, advocacy, and influencing the political agenda in the health field. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505933 Fri, 16 Dec 2011 09:35:54 +0100 5505933 The Journal of Hepatology: An international journal in a new era http://www.medworm.com/index.php?rid=5505932&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006763%2Fabstract%3Frss%3Dyes The Journal of Hepatology, the journal of the European Association for the Study of the Liver (EASL), is entering a new era. Twenty-six years after its creation, the Impact factor (IF) has reached the level of 9.34. This achievement ranks our journal among the top four journals in the field of hepato-gastroenterology and the second in the field of hepatology; moreover, the gap between the top three journals and the Journal of Hepatology has been dramatically reduced. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505932 Fri, 16 Dec 2011 09:35:54 +0100 5505932 Contents http://www.medworm.com/index.php?rid=5505930&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006957%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505930 Fri, 16 Dec 2011 09:35:54 +0100 5505930 EASL Clinical School 2012 Bologna http://www.medworm.com/index.php?rid=5505929&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006933%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505929 Fri, 16 Dec 2011 09:35:54 +0100 5505929 International Liver Congress 2012 http://www.medworm.com/index.php?rid=5505928&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006921%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505928 Fri, 16 Dec 2011 09:35:54 +0100 5505928 EASL Fellowships http://www.medworm.com/index.php?rid=5505927&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS016882781100691X%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505927 Fri, 16 Dec 2011 09:35:54 +0100 5505927 EASL Premium Sponsors http://www.medworm.com/index.php?rid=5505926&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006908%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505926 Fri, 16 Dec 2011 09:35:54 +0100 5505926 Editorial Board http://www.medworm.com/index.php?rid=5505925&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006891%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505925 Fri, 16 Dec 2011 09:35:54 +0100 5505925 Reply to: “Modulation of the effect of PNPLA3 I148M mutation on steatosis and liver damage by alcohol intake in patients with chronic hepatitis C” http://www.medworm.com/index.php?rid=5423073&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005691%2Fabstract%3Frss%3Dyes PNPLA3 rs738409 and fibrosis progression in chronic hepatitis C – There is more to it than just fat! To the Editor: (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423073 Sat, 19 Nov 2011 09:53:38 +0100 5423073 Modulation of the effect of PNPLA3 I148M mutation on steatosis and liver damage by alcohol intake in patients with chronic hepatitis C http://www.medworm.com/index.php?rid=5423072&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS016882781100568X%2Fabstract%3Frss%3Dyes The Patatin-like phospholipase domain-containing-3 (PNPLA3) rs738409 polymorphism, encoding for the I148M protein variant, is a strong genetic determinant of hepatic fat accumulation and progressive alcoholic as well as nonalcoholic steatohepatitis in adults and children , explaining almost a quarter of cirrhosis variability in alcoholic liver disease . We and others have demonstrated that in patients with chronic hepatitis C (CHC), this genetic factor influences steatosis development in nongenotype 3 patients, the progression of liver damage, and susceptibility to develop cirrhosis and its complications (). (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423072 Sat, 19 Nov 2011 09:53:38 +0100 5423072 Contents http://www.medworm.com/index.php?rid=5423024&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006271%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423024 Sat, 19 Nov 2011 09:53:25 +0100 5423024 EASL JHep cover competition http://www.medworm.com/index.php?rid=5423023&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006258%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423023 Sat, 19 Nov 2011 09:53:25 +0100 5423023 EASL Many Ways renewal/ILC Barcelona http://www.medworm.com/index.php?rid=5423022&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006246%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423022 Sat, 19 Nov 2011 09:53:25 +0100 5423022 EASL Monothematic Birmingham http://www.medworm.com/index.php?rid=5423021&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006234%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423021 Sat, 19 Nov 2011 09:53:25 +0100 5423021 EASL Season’s Greetings http://www.medworm.com/index.php?rid=5423020&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006222%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423020 Sat, 19 Nov 2011 09:53:25 +0100 5423020 Editorial Board http://www.medworm.com/index.php?rid=5423019&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006210%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423019 Sat, 19 Nov 2011 09:53:25 +0100 5423019 Reply to: “Modulation of the effect of PNPLA3 I148M mutation on steatosis and liver damage by alcohol intake in patients with chronic hepatitis C” http://www.medworm.com/index.php?rid=5409497&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811005691%2Fabstract%3Frss%3Dyes PNPLA3 rs738409 and fibrosis progression in chronic hepatitis C – There is more to it than just fat! To the Editor: (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5409497 Thu, 17 Nov 2011 00:36:58 +0100 5409497 Modulation of the effect of PNPLA3 I148M mutation on steatosis and liver damage by alcohol intake in patients with chronic hepatitis C http://www.medworm.com/index.php?rid=5409496&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS016882781100568X%2Fabstract%3Frss%3Dyes The Patatin-like phospholipase domain-containing-3 (PNPLA3) rs738409 polymorphism, encoding for the I148M protein variant, is a strong genetic determinant of hepatic fat accumulation and progressive alcoholic as well as nonalcoholic steatohepatitis in adults and children , explaining almost a quarter of cirrhosis variability in alcoholic liver disease . We and others have demonstrated that in patients with chronic hepatitis C (CHC), this genetic factor influences steatosis development in nongenotype 3 patients, the progression of liver damage, and susceptibility to develop cirrhosis and its complications (). (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5409496 Thu, 17 Nov 2011 00:36:58 +0100 5409496 Contents http://www.medworm.com/index.php?rid=5409447&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811006271%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5409447 Thu, 17 Nov 2011 00:36:58 +0100 5409447 EASL JHep cover competition http://www.medworm.com/index.php?rid=5409446&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811006258%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5409446 Thu, 17 Nov 2011 00:36:58 +0100 5409446 EASL Many Ways renewal/ILC Barcelona http://www.medworm.com/index.php?rid=5409445&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811006246%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5409445 Thu, 17 Nov 2011 00:36:58 +0100 5409445 EASL Monothematic Birmingham http://www.medworm.com/index.php?rid=5409444&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811006234%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5409444 Thu, 17 Nov 2011 00:36:58 +0100 5409444 EASL Season’s Greetings http://www.medworm.com/index.php?rid=5409443&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811006222%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5409443 Thu, 17 Nov 2011 00:36:58 +0100 5409443 Editorial Board http://www.medworm.com/index.php?rid=5409442&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811006210%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5409442 Thu, 17 Nov 2011 00:36:58 +0100 5409442 Contents http://www.medworm.com/index.php?rid=5324545&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811005848%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5324545 Tue, 18 Oct 2011 10:42:57 +0100 5324545 EASL Call for Proposals http://www.medworm.com/index.php?rid=5324544&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811005824%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5324544 Tue, 18 Oct 2011 10:42:57 +0100 5324544 EASL Birmingham Monothematic Conference http://www.medworm.com/index.php?rid=5324543&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811005812%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5324543 Tue, 18 Oct 2011 10:42:57 +0100 5324543 EASL Lisbon Special Conference http://www.medworm.com/index.php?rid=5324542&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811005800%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5324542 Tue, 18 Oct 2011 10:42:57 +0100 5324542 EASL Cover Contest http://www.medworm.com/index.php?rid=5324541&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811005794%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5324541 Tue, 18 Oct 2011 10:42:57 +0100 5324541 Editorial Board http://www.medworm.com/index.php?rid=5324540&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811005782%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5324540 Tue, 18 Oct 2011 10:42:57 +0100 5324540 Focus http://www.medworm.com/index.php?rid=5598712&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811007343%2Fabstract%3Frss%3Dyes Advanced hepatic fibrosis is associated with a worse prognosis in patients with chronic hepatitis C virus (HCV) infection. Cumulative clinical experience also suggests that response rates to anti-viral therapy with pegylated interferons α2a or α2b and ribavirin are inversely proportional to the degree of fibrosis. The mechanism involved in the overall hyporesponsiveness to anti-viral treatment in patients with advanced fibrosis is not completely understood. At present, it is not clear whether advanced fibrosis per se is a key factor in the reduced responsiveness to anti-viral therapy or whether the different configuration of the pegylated interferon molecules and their impact on various genes expression play a role in this phenomenon. Among the various factors which have been implicated ... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598712 Tue, 18 Oct 2011 04:00:00 +0100 5598712 Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma http://www.medworm.com/index.php?rid=5598739&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811007215%2Fabstract%3Frss%3Dyes COMMENTARY ON:: Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma. Park JW, Finn RS, Kim JS, Karwal M, Li RK, Ismail F, Thomas M, Harris R, Baudelet C, Walters I, Raoul JL. Clin Cancer Res 2011 Apr 1;17(7):1973–1983.http://www.ncbi.nlm.nih.gov/pubmed/21349999 (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598739 Thu, 29 Sep 2011 04:00:00 +0100 5598739 HIF-1α is a major and complex player in alcohol induced liver diseases http://www.medworm.com/index.php?rid=5598715&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811007240%2Fabstract%3Frss%3Dyes Hepatic steatosis is one of the earliest and most consistent changes which occur with excessive consumption of alcohol. The development of steatosis is known to sensitize the liver to other insults, and is an important step towards the development of the full spectrum of alcohol-induced liver pathologies . The combination of high energy consumption by hepatocytes, and the venous inflow into the liver place hepatocytes at risk of hypoxia. Alcohol consumption was shown to increase hepatic oxygen consumption, with a smaller increase in hepatic oxygen delivery, resulting in central venous hypoxia . These findings bring together the fields of alcoholic liver disease and tissue adaptation to hypoxia. Adaptation to low oxygen tension is known to be regulated by transcriptional induction of genes ... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598715 Thu, 29 Sep 2011 04:00:00 +0100 5598715 Yes! Statins can be given to liver patients http://www.medworm.com/index.php?rid=5598713&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811007252%2Fabstract%3Frss%3Dyes Statins are given to 10–20% of adults in developed countries. Statins increase alanine aminotransferase (ALT) concentrations in 10% of patients without liver disease, and this increase can exceed more than three times the upper limit of normal in 1% of such patients. In contrast, we will note that this ALT escalation does not appear to occur when statins are initiated in patients with fatty liver or hepatitis C. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598713 Thu, 29 Sep 2011 04:00:00 +0100 5598713 Chronic intermittent hypoxia: A breath of fresh air in the understanding of NAFLD pathogenesis http://www.medworm.com/index.php?rid=5505938&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006751%2Fabstract%3Frss%3Dyes Obesity and its comorbidities have reached dramatic worldwide epidemic proportions over the last decade leading to a growing attention raised by the politics and the medical community. Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome is widely observed in obese subjects. NAFLD encompasses a large spectrum of liver injuries ranging from simple steatosis to steatohepatitis (NASH) and cirrhosis with a risk of hepatocellular carcinoma . In this setting, NAFLD has emerged as a major public health issue all over the world. However, its pathogenesis is still poorly understood and its relative treatments remain insufficient. Obstructive sleep apnea (OSA) that consists of upper airway obstruction leading to intermittent hypoxia (IH), affects 25–50% of the ... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505938 Mon, 19 Sep 2011 04:00:00 +0100 5505938 The invaders and the barrier http://www.medworm.com/index.php?rid=5505935&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS016882781100674X%2Fabstract%3Frss%3Dyes Barriers exist to protect. The first images of World War II show the invaders breaking a barrier at the border of Poland, signifying the end of a peaceful world and the beginning of chaos… This is analogous to viral resistance to antiviral drugs. The invader is the drug-resistant virus; this virus preexists as poorly fit, minority viral populations. The “barrier to resistance” of a drug or a drug combination prevents their outgrowth in the presence of the drug(s), thus preventing virological breakthrough, disease progression, and eventually severe complications. If the barrier to resistance is high enough, resistant viral variants are not selected and do not grow; if it is not, they rapidly fill in the replication space and become the dominant (or exclusive) viral population associat... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505935 Mon, 19 Sep 2011 04:00:00 +0100 5505935 Recombinant factor VIIa to treat severe bleeding in patients with liver disease: Pitfalls and possibilities http://www.medworm.com/index.php?rid=5227058&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811004387%2Fabstract%3Frss%3Dyes Patients with liver disease frequently develop substantial changes in their hemostatic system . Recent laboratory and clinical data are compatible with the concept of rebalanced hemostasis in liver disease . According to this concept, the average patient with liver disease is in hemostatic balance due to a concomitant decrease in pro- and anticoagulant pathways. The hemostatic balance in patients with liver disease, however, is much more fragile as compared to the hemostatic balance in healthy individuals. Consequently, patients with liver disease are at risk for both bleeding and thrombosis when the balance is disturbed. Unfortunately, there is currently no clinical or laboratory test able to predict whether a patient with liver disease is at risk for either bleeding or thrombosis. (Sourc... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5227058 Mon, 19 Sep 2011 01:50:21 +0100 5227058 Contents http://www.medworm.com/index.php?rid=5227020&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811004557%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5227020 Mon, 19 Sep 2011 01:50:20 +0100 5227020 EASL International Liver Congress, Barcelona, Spain http://www.medworm.com/index.php?rid=5227019&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811004533%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5227019 Mon, 19 Sep 2011 01:50:20 +0100 5227019 EASL Monothematic Conference, Birmingham, UK http://www.medworm.com/index.php?rid=5227018&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811004521%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5227018 Mon, 19 Sep 2011 01:50:20 +0100 5227018 EASL Special Conference, Lisbon, Portugal http://www.medworm.com/index.php?rid=5227017&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS016882781100451X%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5227017 Mon, 19 Sep 2011 01:50:20 +0100 5227017 EASL Fellowship Programme http://www.medworm.com/index.php?rid=5227016&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811004508%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5227016 Mon, 19 Sep 2011 01:50:20 +0100 5227016 Editorial Board http://www.medworm.com/index.php?rid=5227015&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811004491%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5227015 Mon, 19 Sep 2011 01:50:20 +0100 5227015 A variant in myeloperoxidase promoter hastens the emergence of hepatocellular carcinoma in patients with HCV-related cirrhosis http://www.medworm.com/index.php?rid=5598732&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006726%2Fabstract%3Frss%3Dyes Background & Aims: Genetic dimorphisms modulate the activities of several pro- or antioxidant enzymes, including myeloperoxidase (MPO), catalase (CAT), manganese superoxide dismutase (SOD2), and glutathione peroxidase 1 (GPx1). We assessed the role of the G(−463)A-MPO, T(−262)C-CAT, Ala16Val-SOD2, and Pro198Leu-GPx1 variants in modulating HCC development in patients with HCV-induced cirrhosis.Methods: Two hundred and five patients with HCV-induced, biopsy-proven cirrhosis but without detectable HCC at inclusion were prospectively followed-up for HCC development. The influence of various genotypes on HCC occurrence was assessed with the Kaplan–Meier method.Results: During follow-up (103.2±3.4months), 84 patients (41%) developed HCC, and 66 died. Whereas the Ala16Val-SOD2 or Pro198Leu... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598732 Thu, 08 Sep 2011 04:00:00 +0100 5598732 Focus http://www.medworm.com/index.php?rid=5505931&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006659%2Fabstract%3Frss%3Dyes Efforts to understand hepatocellular carcinoma (HCC) are at a fever pitch because of the epidemic incidence of the disease and the paradigm-shifting SHARP trial , which established this neoplasm as a tractable target for molecular therapies. As a result, identifying new molecular targets and improving the diagnosis of early disease are major points of attack, and two articles from this month’s issue address these important topics. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505931 Thu, 08 Sep 2011 04:00:00 +0100 5505931 HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice http://www.medworm.com/index.php?rid=5598734&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006593%2Fabstract%3Frss%3Dyes Conclusions: The current results provide direct evidence for protective roles of HIF-1 induction in the development of ethanol-induced fatty liver via activation of the HIF-1-regulated transcriptional repressor DEC1. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598734 Wed, 07 Sep 2011 04:00:00 +0100 5598734 C reactive protein levels in non-alcoholic fatty liver disease http://www.medworm.com/index.php?rid=5598750&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006532%2Fabstract%3Frss%3Dyes Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. It represents a wide spectrum of conditions ranging from fatty liver, which in general follows a benign, non-progressive clinical course, to nonalcoholic steatohepatitis (NASH), a more serious form of NAFLD that may progress to cirrhosis and end-stage liver disease. Accurate evaluation of liver fibrosis in patients with NAFLD is important to identify patients who may develop complications. Over time, several biological markers have been studied for evaluating the extent of steatosis, the presence of necroinflammation, and the development of fibrosis to avoid performing liver biopsy, an invasive procedure that still represents the gold standard of diagnosis. The most important parameter to be id... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598750 Fri, 02 Sep 2011 04:00:00 +0100 5598750 Inducible and repressable oncogene-addicted hepatocellular carcinoma in Tet-on xmrk transgenic zebrafish http://www.medworm.com/index.php?rid=5598731&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS016882781100660X%2Fabstract%3Frss%3Dyes Conclusions: Our zebrafish model demonstrates the potential of a hyperactivated epidermal growth factor receptor pathway in initiating heptocarcinogenesis. It provides clear evidence for the requirement of only a single oncogene for HCC initiation and maintenance and is thus a convenient model for further investigation of oncogene addiction and future anti-cancer drug screening. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598731 Fri, 02 Sep 2011 04:00:00 +0100 5598731 MicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinoma http://www.medworm.com/index.php?rid=5598727&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006647%2Fabstract%3Frss%3Dyes Conclusions: Our data suggest an important role for miR-135a in promoting PVTT tumorigenesis and indicate the potential application of miR-135a in PVTT therapy. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598727 Fri, 02 Sep 2011 04:00:00 +0100 5598727 Hepatotoxicity associated with statins: Reports of idiosyncratic liver injury post-marketing http://www.medworm.com/index.php?rid=5598725&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006581%2Fabstract%3Frss%3Dyes Conclusions: Idiosyncratic liver injury associated with statins is rare but can be severe. After recovery, a similar pattern of liver injury can be reproduced on re-exposure. Most patients experience liver injury 3–4months after start of therapy. Atorvastatin is mostly associated with cholestatic liver injury whereas hepatocellular injury is more common with simvastatin. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598725 Fri, 02 Sep 2011 04:00:00 +0100 5598725 Determination of IL28B polymorphisms in liver biopsies obtained after liver transplantation http://www.medworm.com/index.php?rid=5598722&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006623%2Fabstract%3Frss%3Dyes Conclusions: Our results support that follow-up liver biopsies from LT recipients are not suitable for determining donor IL28B rs12979860 genotype by TaqMan real-time PCR or direct sequencing and that PBMC or reperfusion biopsies should be used instead. Thus, it is very important to obtain adequate samples in order to accurately determine the relative contributions of both donor and recipient. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598722 Fri, 02 Sep 2011 04:00:00 +0100 5598722 A functional genomic screen reveals novel host genes that mediate interferon-alpha’s effects against hepatitis C virus http://www.medworm.com/index.php?rid=5598718&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006611%2Fabstract%3Frss%3Dyes Conclusions: We identified 93 genes that mediate the anti-HCV effect of IFN-α through genome-wide siRNA screening; 23 and nine genes were involved in mRNA processing and translation initiation, respectively. These findings reveal an unexpected role for mRNA processing in generation of the antiviral state, and suggest a new avenue for therapeutic development in HCV. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598718 Fri, 02 Sep 2011 04:00:00 +0100 5598718 Reply to: “C-reactive protein levels in non-alcoholic fatty liver disease” http://www.medworm.com/index.php?rid=5598751&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006520%2Fabstract%3Frss%3Dyes We thank Dr. Dogru et al. for their comments on our paper on C-reactive protein (CRP) levels in relation to various features of non-alcoholic fatty liver disease (NAFLD) among obese patients . In our study of 627 obese adults with liver histology and measures of body mass index (BMI, kg/m2), and high sensitivity (hs)-CRP, we confirmed a strong association between BMI and hs-CRP, with a 20% increase in hs-CRP level per 10% increase in BMI. Also, we observed a positive association between hs-CRP and liver steatosis, but no BMI independent association between hs-CRP and non-alcoholic steato-hepatitis (NASH), hence questioning whether CRP can be used as a marker of severity of NAFLD . (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598751 Wed, 31 Aug 2011 04:00:00 +0100 5598751 Dermatological side effects of hepatitis C and its treatment: Patient management in the era of direct-acting antivirals http://www.medworm.com/index.php?rid=5598736&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS016882781100657X%2Fabstract%3Frss%3Dyes Summary: Dermatological adverse events (AEs) are an existing concern during hepatitis C virus (HCV) infection and peginterferon/ribavirin treatment. HCV infection leads to dermatological and muco-cutaneous manifestations including small-vessel vasculitis as part of the mixed cryoglobulinemic syndrome. Peginterferon/ribavirin treatment is associated with well-characterized dermatological AEs tending towards a uniform entity of dermatitis. New direct-acting antivirals have led to significant improvements in sustained virologic response rates, but several have led to an increase in dermatological AEs versus peginterferon/ribavirin alone. In telaprevir trials, approximately half of treated patients had rash. More than 90% of these events were Grade 1 or 2 (mild/moderate) and in the majority (9... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598736 Tue, 30 Aug 2011 04:00:00 +0100 5598736 Touching some firm ground in the epidemiology of NASH http://www.medworm.com/index.php?rid=5505939&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006507%2Fabstract%3Frss%3Dyes Anyone trying to understand the burden of disease of NAFLD in our societies might feel like they are trapped in a labyrinth, under a dim light. A labyrinth, because there are many ways to look for NAFLD and not just one straightforward diagnostic method. Under a dim light, because all these imperfect procedures and tests do not allow us to see far enough, given their limited sensitivity and specificity. Yet, for all these uncertainties, the sense of facing a real problem is overwhelmingly present. Just as it should be when you are trapped in a labyrinth. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505939 Mon, 29 Aug 2011 04:00:00 +0100 5505939 Salvage liver transplantation for recurrent hepatocellular carcinoma after radiofrequency ablation: A new strategy? http://www.medworm.com/index.php?rid=5505936&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006490%2Fabstract%3Frss%3Dyes In this issue of the Journal, Dr. Nkontchou et al. describe the recurrence and survival outcomes of a retrospective cohort of 67 patients diagnosed with hepatocellular carcinoma (HCC) within the Milan criteria between 2000 and 2007, who were treated at a single center in France with percutaneous radiofrequency ablation (RFA), followed by close surveillance and salvage transplant for liver failure or recurrence . Among the 64 patients who achieved complete response to RFA, 38 (59.4%) experienced recurrence within 5years. Twenty-one patients with recurrence were treated by liver transplantation, 14 were ineligible due to recurrence outside of the Milan Criteria, and 3 declined transplant and were treated with repeat RFA. Three additional patients from the original cohort required transplanta... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505936 Fri, 26 Aug 2011 04:00:00 +0100 5505936 Autophagy and hepatic stellate cell activation – Partners in crime? http://www.medworm.com/index.php?rid=5423028&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006180%2Fabstract%3Frss%3Dyes Following liver injury, hepatic stellate cells (HSCs) lose their characteristic lipid droplets to differentiate into extracellular matrix producing myofibroblasts. Activation of HSCs is considered one of the main mechanisms contributing to the development of hepatic fibrosis in chronic liver diseases . Although several key pathways for HSC activation, such as TGFβ and PDGF have been identified, there is still a lack of clinically applicable approaches to target HSCs for anti-fibrotic therapies. Identification of additional pathways involved in HSC activation may reveal more suitable anti-fibrotic targets than those already identified. The study by Thoen et al. in this issue of the Journal of Hepatology investigates the role of autophagy in HSC activation and the loss of HSC lipid stores, ... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423028 Mon, 22 Aug 2011 04:00:00 +0100 5423028 Contents http://www.medworm.com/index.php?rid=5132824&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811003953%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5132824 Tue, 16 Aug 2011 22:58:25 +0100 5132824 EASL International Liver Congress 2012, Barcelona, Spain http://www.medworm.com/index.php?rid=5132823&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS016882781100393X%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5132823 Tue, 16 Aug 2011 22:58:25 +0100 5132823 EASL Monothematic Conference, Birmingham, UK http://www.medworm.com/index.php?rid=5132822&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811003928%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5132822 Tue, 16 Aug 2011 22:58:25 +0100 5132822 EASL Special Conference, Lisbon, Portugal http://www.medworm.com/index.php?rid=5132821&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811003916%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5132821 Tue, 16 Aug 2011 22:58:25 +0100 5132821 EASL Fellowship Programme http://www.medworm.com/index.php?rid=5132820&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811003904%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5132820 Tue, 16 Aug 2011 22:58:25 +0100 5132820 Editorial Board http://www.medworm.com/index.php?rid=5132819&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811003898%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5132819 Tue, 16 Aug 2011 22:58:25 +0100 5132819 Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo http://www.medworm.com/index.php?rid=5505960&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005757%2Fabstract%3Frss%3Dyes Conclusions: Our findings suggest that a combining-regimen of mTORKi and HDACi may be an effective therapeutic strategy for HCC. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505960 Wed, 10 Aug 2011 04:00:00 +0100 5505960 Realize the advance in HCV treatment, but remain cautious http://www.medworm.com/index.php?rid=5423067&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006143%2Fabstract%3Frss%3Dyes COMMENTARY ON Telaprevir for previously untreated chronic hepatitis C virus infection. Jacobson IM, McHutchison JG, Dusheiko G, Di Bisceglie AM, Reddy KR, Bzowej NH, Marcellin P, Muir AJ, Ferenci P, Flisiak R, George J, Rizzetto M, Shouval D, Sola R, Terg RA, Yoshida EM, Adda N, Bengtsson L, Sankoh AJ, Kieffer TL, George S, Kauffman RS, Zeuzem S; ADVANCE Study Team. N Engl J Med. 2011 Jun 23;364(25):2405–2416. Copyright (2011). Abstract reprinted with permission of the Massachusetts Medical Society. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423067 Wed, 10 Aug 2011 04:00:00 +0100 5423067 Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver http://www.medworm.com/index.php?rid=5505963&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006131%2Fabstract%3Frss%3Dyes Conclusions: Altogether, our study, by reporting that G6P is the glucose-signaling metabolite, challenges the PP2A/X5P-dependent model currently described for ChREBP activation in response to glucose in liver. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505963 Tue, 09 Aug 2011 04:00:00 +0100 5505963 GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation http://www.medworm.com/index.php?rid=5505961&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS016882781100612X%2Fabstract%3Frss%3Dyes Conclusions: We identified for the first time the association between two rare diseases, MCA syndrome and HCA occurrence, but also that somatic GNAS-activating mutations in sporadic benign and malignant liver tumors are characterized by an inflammatory phenotype. These results showed a cross-talk between cyclic-AMP and JAK/STAT pathways in liver tumors and they reinforce the role of STAT3 activation in liver tumorigenesis. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505961 Tue, 09 Aug 2011 04:00:00 +0100 5505961 Ornithine phenylacetate prevents disturbances of motor-evoked potentials induced by intestinal blood in rats with portacaval anastomosis http://www.medworm.com/index.php?rid=5505951&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006052%2Fabstract%3Frss%3Dyes Background & Aims: Ornithine phenylacetate (OP) is a new drug that has been proposed for the treatment of hepatic encephalopathy (HE) because it decreases plasma ammonia. We performed a study to assess if OP would impact on neuronal function.Methods: Motor-evoked potentials (MEP), a surrogate of hepatic encephalopathy, were assessed (without anesthesia) in rats with portacaval anastomosis (PCA) that received gastrointestinal blood (GIB). Rats were pre-treated with OP prior to GIB. Ammonia and related metabolites (plasma, urine, and brain microdialysis) were assessed by HPLC and mass spectroscopy.Results: OP (one dose or 3days) prevented disturbances in MEP induced by GIB in PCA rats. In rats treated with OP for 3days, the amplitude and latency of MEP remained stable (−1% and +1%), while ... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505951 Tue, 09 Aug 2011 04:00:00 +0100 5505951 Prospective evaluation of the prognostic scores for cirrhotic patients admitted to an Intensive Care Unit http://www.medworm.com/index.php?rid=5505949&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006039%2Fabstract%3Frss%3Dyes Conclusions: For cirrhotic patients admitted to the ICU, SAPS II, and SOFA scores predicted ICU mortality better than liver-specific scores. Mechanical ventilation or vasopressor therapy, bilirubin levels at admission and infection in patients with advanced cirrhosis were associated with a poor outcome. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505949 Tue, 09 Aug 2011 04:00:00 +0100 5505949 Development of a new in situ hybridization method for the detection of global bacterial DNA to provide early evidence of a bacterial infection in spontaneous bacterial peritonitis http://www.medworm.com/index.php?rid=5505948&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006040%2Fabstract%3Frss%3Dyes Conclusions: Our newly established ISH method was found to provide both a rapid and sensitive detection of bacterial DNA in SBP ascites, thus suggesting its utility for providing early and direct evidence of bacterial infection in SBP ascites. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505948 Tue, 09 Aug 2011 04:00:00 +0100 5505948 Targeted impairment of innate antiviral responses in the liver of chronic hepatitis C patients http://www.medworm.com/index.php?rid=5505946&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006118%2Fabstract%3Frss%3Dyes Conclusions: Altogether the data argue for a strong viral strategy that counteracts the host’s early antiviral response of hepatocytes from chronic patients without impairing ISGs induced via classical IFN pathway. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505946 Tue, 09 Aug 2011 04:00:00 +0100 5505946 Ligand-dependent corepressor acts as a novel corepressor of thyroid hormone receptor and represses hepatic lipogenesis in mice http://www.medworm.com/index.php?rid=5505969&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006076%2Fabstract%3Frss%3Dyes Conclusions: Our data suggest that LCOR is likely to suppress TRβ1-mediated hepatic lipogenesis by decreasing binding and recruitment of SRCs to TRβ1. Our study reveals the physiological function of hepatic LCOR in lipid metabolism and the mechanism by which LCOR regulates lipogenesis. Hepatic LCOR may be a potential target for treating hepatic steatosis. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505969 Mon, 08 Aug 2011 04:00:00 +0100 5505969 SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism http://www.medworm.com/index.php?rid=5505964&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS016882781100609X%2Fabstract%3Frss%3Dyes Conclusions: Our study demonstrates that SRC-3 is the predominant transcriptional co-activator among the three SRC family members for CAR activation to promote hepatocyte proliferation and drug metabolism. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505964 Mon, 08 Aug 2011 04:00:00 +0100 5505964 Assessment of portal hypertension by transient elastography in patients with compensated cirrhosis and potentially resectable liver tumors http://www.medworm.com/index.php?rid=5505950&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006064%2Fabstract%3Frss%3Dyes Background & Aims: Patients with cirrhosis and small hepatocellular carcinoma with normal bilirubin and hepatic venous pressure gradient (HVPG) 70% 5-year survival after hepatic resection. On the contrary, patients with HVPG ⩾10mm Hg (clinically significant portal hypertension, CSPH) frequently develop decompensation following surgery, with around 50% 5-year survival. Liver stiffness (LS) evaluation by transient elastography might non-invasively identify CSPH. We investigated the usefulness of LS predicting CSPH in patients with compensated cirrhosis and potentially resectable liver tumors.Methods: Ninety-seven consecutive Child-Pugh A patients with potentially resectable liver tumors referred for HVPG measurement were prospectively evaluated. In fasting conditions LS was measured before... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505950 Mon, 08 Aug 2011 04:00:00 +0100 5505950 Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan http://www.medworm.com/index.php?rid=5505947&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006106%2Fabstract%3Frss%3Dyes Background & Aims: To evaluate the efficacy and safety of telaprevir in combination with peginterferon-α2b (PEG-IFN) and ribavirin (RBV) in patients with chronic hepatitis C.Methods: In a multi-center randomized clinical trial in Japan, on patients infected with HCV of genotype 1, 126 patients were assigned to telaprevir for 12weeks along with PEG-IFN and RBV for 24weeks (Group A), while 63 to PEG-IFN and RBV for 48weeks (Group B).Results: HCV RNA disappeared more swiftly in patients in Group A than B, and the frequency of patients without detectable HCV RNA at week 4 (rapid virological response (RVR)) was higher in Group A than B (84.0% vs. 4.8%, p (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505947 Mon, 08 Aug 2011 04:00:00 +0100 5505947 Nucleotide change of codon 182 in the surface gene of hepatitis B virus genotype C leading to truncated surface protein is associated with progression of liver diseases http://www.medworm.com/index.php?rid=5505945&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811006088%2Fabstract%3Frss%3Dyes Conclusions: In the present study, we demonstrate that the sW182∗ of HBV could provide an important contribution to the progression of liver diseases, through molecular epidemiologic and in vitro studies. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505945 Mon, 08 Aug 2011 04:00:00 +0100 5505945 Radioembolization for hepatocellular carcinoma http://www.medworm.com/index.php?rid=5598737&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005745%2Fabstract%3Frss%3Dyes Summary: Radioembolization is a form of brachytherapy in which intra-arterially injected 90Y-loaded microspheres serve as sources for internal radiation purposes. It produces average disease control rates above 80% and is usually very well tolerated. Main complications do not result from the microembolic effect, even in patients with portal vein occlusion, but rather from an excessive irradiation of non-target tissues including the liver. All the evidence that support the use of radioembolization in HCC is based on retrospective series or non-controlled prospective studies. However, reliable data can be obtained from the literature, particularly since the recent publication of large series accounting for nearly 700 patients. When compared to the standard of care for the intermediate and ad... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598737 Wed, 03 Aug 2011 04:00:00 +0100 5598737 A role for autophagy during hepatic stellate cell activation http://www.medworm.com/index.php?rid=5423054&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005721%2Fabstract%3Frss%3Dyes Conclusions: During HSC activation, autophagic flux is increased. The demonstration of partly inhibition of in vitro HSC activation after treatment with an autophagy inhibitor unveils a potential new therapeutic strategy for liver fibrosis. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423054 Mon, 01 Aug 2011 04:00:00 +0100 5423054 Focus http://www.medworm.com/index.php?rid=5423025&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005733%2Fabstract%3Frss%3Dyes Transarterial chemoembolization (TACE) was the first loco-regional ablative therapy for hepatocellular carcinoma (HCC), developed in Japan in the early 1980s . The procedure involved intra arterial injection into the hepatic artery of a suspension of the radiologic contrast agent lipiodol (derived from poppy seed oil) mixed with adriamycin . The technique was rapidly adopted by Japanese hepatologists and oncologists but it took almost two decades until it was accepted in the Western hemisphere . The procedure underwent a number of modifications over the years including the introduction of additional chemotherapeutic agents instead of adriamycin as well as bland particle embolization intended to induce tumor ischemia and necrosis without using a chemotherapeutic agent. Two meta-analyses hav... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423025 Mon, 01 Aug 2011 04:00:00 +0100 5423025 A role for autophagy during hepatic stellate cell activation http://www.medworm.com/index.php?rid=5409478&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811005721%2Fabstract%3Frss%3Dyes Conclusions: During HSC activation, autophagic flux is increased. The demonstration of partly inhibition of in vitro HSC activation after treatment with an autophagy inhibitor unveils a potential new therapeutic strategy for liver fibrosis. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5409478 Mon, 01 Aug 2011 04:00:00 +0100 5409478 Focus http://www.medworm.com/index.php?rid=5409448&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811005733%2Fabstract%3Frss%3Dyes Transarterial chemoembolization (TACE) was the first loco-regional ablative therapy for hepatocellular carcinoma (HCC), developed in Japan in the early 1980s . The procedure involved intra arterial injection into the hepatic artery of a suspension of the radiologic contrast agent lipiodol (derived from poppy seed oil) mixed with adriamycin . The technique was rapidly adopted by Japanese hepatologists and oncologists but it took almost two decades until it was accepted in the Western hemisphere . The procedure underwent a number of modifications over the years including the introduction of additional chemotherapeutic agents instead of adriamycin as well as bland particle embolization intended to induce tumor ischemia and necrosis without using a chemotherapeutic agent. Two meta-analyses hav... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5409448 Mon, 01 Aug 2011 04:00:00 +0100 5409448 Nanotechnology for therapy and imaging of liver diseases http://www.medworm.com/index.php?rid=5423068&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS016882781100571X%2Fabstract%3Frss%3Dyes Summary: Nanotechnology has been considered for the improved delivery of various therapeutic agents, including drugs and genes. Indeed, liposomes and nanoparticles equipped with homing devices for the targeting of receptors over-expressed on the hepatic tissue have improved the treatment of various liver diseases. In this review, various nanotechnology approaches employed for the treatment/imaging of liver disease, either in preclinical or in clinic are discussed. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423068 Thu, 28 Jul 2011 04:00:00 +0100 5423068 Liver transplant from a donor with occult HEV infection induced chronic hepatitis and cirrhosis in the recipient http://www.medworm.com/index.php?rid=5598744&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005642%2Fabstract%3Frss%3Dyes Abstract: Acute hepatitis E virus (HEV) infection is a self-limiting symptomatic or asymptomatic disease. However, as recently observed, it can manifest itself as chronic hepatitis in patients receiving solid organ transplants as well as in patients with HIV infection or severe hematologic disorders.Here, we describe the clinical course of a 73-year-old male patient in whom HEV transmission occurred after receiving a HEV-infected liver from a donor with occult HEV infection, whereby the patient had tested negative for HEV RNA and anti-HEV antibodies shortly before explantation.Anti-HEV IgG, IgM, and HEV RNA were detected in the first tested serum sample of the liver recipient obtained 150days after liver transplantation and remained positive (earlier samples after OLT were not available). ... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598744 Wed, 27 Jul 2011 04:00:00 +0100 5598744 New horizons for stem cell therapy in liver disease http://www.medworm.com/index.php?rid=5598743&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005654%2Fabstract%3Frss%3Dyes Summary: There is an increasing range of potential applications of stem cells in liver diseases, with many clinical studies already undertaken. We identify four of the main areas which we propose stem cell therapy could be a realistic aim for in the future: (1) to improve regeneration and reduce scarring in liver cirrhosis by modulating the liver’s own regenerative processes, (2) to down-regulate immune mediated liver damage, (3) supplying hepatocyte-like cells (HLCs) derived from stem cells for use in extracorporeal bio-artificial liver machines, and (4) to use stem cell derived HLCs for cell transplantation to supplement or replace hepatocyte function. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598743 Wed, 27 Jul 2011 04:00:00 +0100 5598743 Chimeric mouse model of hepatitis B virus infection http://www.medworm.com/index.php?rid=5598742&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005630%2Fabstract%3Frss%3Dyes Chronic infection with hepatitis B virus (HBV) continues to be a major health problem affecting about 400 million people worldwide. The narrow species tropism of HBV has hindered progresses in HBV research and development of more efficient treatments. Due to strong restraints encountered using chimpanzees and animal models based on HBV-related viruses, recent developments focused on using the natural target of HBV infection: the human hepatocyte. However, in vitro susceptibility of human hepatocytes to HBV is limited and cultured cells may respond differently to the infection and other stimuli than hepatocytes in the liver. Attempts to create mice harboring human chimeric livers led to the establishment of two major models: the urokinase-type plasminogen activator (uPA) transgenic mice and... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598742 Wed, 27 Jul 2011 04:00:00 +0100 5598742 EpCAM in hepatocytes and their progenitors http://www.medworm.com/index.php?rid=5598741&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005629%2Fabstract%3Frss%3Dyes COMMENTARY ON:: Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans. Yoon SM, Gerasimidou D, Kuwahara R, Hytiroglou P, Yoo JE, Park YN, Theise ND. Hepatology 2011 Mar;53(3):964–973.http://www.ncbi.nlm.nih.gov/pubmed/21319194 (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598741 Wed, 27 Jul 2011 04:00:00 +0100 5598741 Back to basics: Staging and prognosis in HCC for medical oncologist http://www.medworm.com/index.php?rid=5598740&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005678%2Fabstract%3Frss%3Dyes COMMENTARY ON:: Advanced hepatocellular carcinoma: which staging systems best predict prognosis? Huitzil-Melendez FD, Capanu M, O’Reilly EM, Duffy A, Gansukh B, Saltz LL, Abou-Alfa GK. J Clin Oncol 2010 Jun 10;28(17):2889–95.http://www.ncbi.nlm.nih.gov/pubmed/20458042 (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598740 Wed, 27 Jul 2011 04:00:00 +0100 5598740 NKG2D and its ligands: Key to immunotherapy of liver cancer? http://www.medworm.com/index.php?rid=5598714&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005666%2Fabstract%3Frss%3Dyes Hepatocellular carcinoma (HCC) is a common cancer accounting for a significant proportion of all cancers worldwide. Although most cases of HCC occur in countries where hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are endemic, the tumour is ubiquitous and one of the most challenging complications of advanced liver disease. HCC develops deviously and there are currently no reliable biomarkers for early diagnosis. Indeed, because alpha-foetoprotein (AFP) has poor sensitivity and specificity, and other serological markers such as des-gamma-carboxyprothrombin (DCP), and Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) perform only slightly better , abdominal ultrasound is presently considered the tool of choice for surveillance of patients at risk. Treatment of HCC ... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598714 Wed, 27 Jul 2011 04:00:00 +0100 5598714 Adding to the toolbox: Receptor tyrosine kinases as potential targets in the treatment of hepatitis C http://www.medworm.com/index.php?rid=5505974&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005575%2Fabstract%3Frss%3Dyes COMMENTARY ON:: EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Lupberger J, Zeisel MB, Xiao F, Thumann C, Fofana I, Zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D, Fresquet J, Cosset FL, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P, Doffoël M, Raffelsberger W, Poch O, McKeating JA, Brino L, Baumert TF. Nat Med. 2011 May;17(5):589–95. Copyright (2011). Abstract reprinted with permission from MacMillan Publishers Ltd.http://www.ncbi.nlm.nih.gov/pubmed/21516087Abstract:: Hepatitis C virus (HCV) is a major cause of liver disease, but therapeutic options are limited and there are no prevention strategies. Viral entry is the first step of infection and requires the cooperative interaction of s... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505974 Mon, 25 Jul 2011 04:00:00 +0100 5505974 Reply to: “Ammonia and cerebral water. Importance of structural analysis of the brain in hepatic encephalopathy” http://www.medworm.com/index.php?rid=5598749&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005460%2Fabstract%3Frss%3Dyes We thank McPhail et al. for their comments regarding our paper in which we reported that induced hyperammonaemia in patients with hepatic encephalopathy (HE) leads to a transient increase in brain water apparent diffusion coefficient (ADC) reported from diffusion tensor imaging (DTI), accompanied by a decrease in frontal white matter myo-inositol (mI) measured by proton magnetic resonance spectroscopy (MRS). McPhail et al. suggest that assessment of regional brain volume changes using voxel-based morphometry (VBM) would provide additional evidence available from our existing MR data as to the pathophysiological significance of brain water and low grade cerebral oedema in HE. In response to these comments, we have revisited the structural scans acquired during our study and performed a post... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598749 Fri, 22 Jul 2011 04:00:00 +0100 5598749 Herbal medicine hepatotoxicity revisited http://www.medworm.com/index.php?rid=5598746&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005496%2Fabstract%3Frss%3Dyes This article gives several examples of specific ingredients alleged to have been associated with cases of liver injury including references to Herbalife which is a brand, not a single product or ingredient. The reference to Herbalife is also somewhat immaterial in the context of the article’s discussion. Herbalife has formally responded to this publication to rebut articles cited by these authors . The articles were published in 2007 and present case reports with dates of onset that range from 1998 to 2004. These case reports involved a variety of food and supplement products that are not representative of currently marketed Herbalife products. Additionally, no toxic substance has been identified as responsible for the liver reactions that were alleged to have been associated with Herbal... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598746 Fri, 22 Jul 2011 04:00:00 +0100 5598746 Liver transplantation using Donation after Cardiac Death donors http://www.medworm.com/index.php?rid=5598738&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005526%2Fabstract%3Frss%3Dyes This article covers this expansion, current results, pitfalls, and steps taken to minimize complications and to improve outcome, and future developments that are likely to occur. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598738 Fri, 22 Jul 2011 04:00:00 +0100 5598738 Novel insights in the genetics of HCC recurrence and advances in transcriptomic data integration http://www.medworm.com/index.php?rid=5505973&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005599%2Fabstract%3Frss%3Dyes Conclusions: We developed a composite prognostic model for HCC recurrence, based on gene expression patterns in tumor and adjacent tissues. These signatures predict early and overall recurrence in patients with HCC, and complement findings from clinical and pathology analyses. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505973 Fri, 22 Jul 2011 04:00:00 +0100 5505973 Peginterferon maintenance therapy in patients with advanced hepatitis C to prevent hepatocellular carcinoma: The plot thickens http://www.medworm.com/index.php?rid=5505972&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005587%2Fabstract%3Frss%3Dyes Conclusions: Extended analysis of the HALT-C cohort showed that long-term peginterferon therapy does not reduce the incidence of HCC among patients with advanced hepatitis C who did not achieve SVRs. Patients with cirrhosis who received peginterferon treatment had a lower risk of HCC than controls. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505972 Fri, 22 Jul 2011 04:00:00 +0100 5505972 Maximum number of target lesions required to measure responses to transarterial chemoembolization using the enhancement criteria in patients with intrahepatic hepatocellular carcinoma http://www.medworm.com/index.php?rid=5598729&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS016882781100523X%2Fabstract%3Frss%3Dyes Conclusions: Our data indicate that evaluating the largest two lesions is generally the most useful procedure for measuring TACE responses under both EASL and mRECIST. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598729 Thu, 21 Jul 2011 04:00:00 +0100 5598729 Molecular diagnosis and therapy of hepatocellular carcinoma (HCC): An emerging field for advanced technologies http://www.medworm.com/index.php?rid=5505971&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005551%2Fabstract%3Frss%3Dyes Despite great progress in diagnosis and management of hepatocellular carcinoma (HCC), the exact biology of the tumor remains poorly understood overall limiting the patients’ outcome. Detailed analysis and characterization of the molecular mechanisms and subsequently individual prediction of corresponding prognostic traits would revolutionize both diagnosis and treatment of HCC and is the key goal of modern personalized medicine. Over the recent years systematic approaches for the analysis of whole tumor genomes and transcriptomes as well as epigenomes became affordable tools in translational research. This includes simultaneous analyses of thousands of molecular targets using microarray-based technologies as well as next-generation sequencing. Although currently diagnosis and classificat... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505971 Thu, 21 Jul 2011 04:00:00 +0100 5505971 The liver X receptor in hepatic stellate cells: A novel antifibrogenic target? http://www.medworm.com/index.php?rid=5423065&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005125%2Fabstract%3Frss%3Dyes COMMENTARY ON: Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. Gastroenterology. 2011 Mar;140(3):1052–1062. Copyright (2011). Abstract reprinted with permission from the American Gastroenterological Association. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423065 Thu, 21 Jul 2011 04:00:00 +0100 5423065 High fructose feeding induces copper deficiency in Sprague–Dawley rats: A novel mechanism for obesity related fatty liver http://www.medworm.com/index.php?rid=5598733&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005368%2Fabstract%3Frss%3Dyes Conclusions: Our data suggest that high fructose-induced nonalcoholic fatty liver disease (NAFLD) may be due, in part, to inadequate dietary copper. Impaired duodenum Ctr-1 expression seen in fructose feeding may lead to decreased copper absorption, and subsequent copper deficiency. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598733 Wed, 20 Jul 2011 04:00:00 +0100 5598733 Sirolimus – It doesn’t deserve its bad Rap(a) http://www.medworm.com/index.php?rid=5505975&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005150%2Fabstract%3Frss%3Dyes There are few medications in the field of transplantation that evoke such strong opinions as Sirolimus – it is either loved or loathed. Initial concerns about side effects and the 2002 black box warning from the Food and Drug Administration (FDA) regarding the risk of hepatic artery thrombosis (HAT) meant that for many years, Sirolimus was not used widely in liver transplantation. However, recent data show that Sirolimus offers potential benefit in specific areas such as hepatocellular carcinoma (HCC) and hepatitis C virus (HCV)-infected grafts, with acceptable risk to benefit ratios. It’s time to recognize that Sirolimus offers safe and effective immune suppression following liver transplantation. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505975 Wed, 20 Jul 2011 04:00:00 +0100 5505975 Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: The ANRS HCEP-23 study http://www.medworm.com/index.php?rid=5505944&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005290%2Fabstract%3Frss%3Dyes Conclusions: Contrarily to blood tests, performance of Fibroscan™ was reduced due to uninterpretable results. Fibrotest®, interpretable Fibroscan™, Fibrometer®, and Hepascore® perform best and similarly for diagnosis of significant fibrosis and cirrhosis. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505944 Wed, 20 Jul 2011 04:00:00 +0100 5505944 Influence of interferon-based therapy on liver fibrosis progression in HIV/HCV coinfected patients: A retrospective repeated liver biopsy analysis http://www.medworm.com/index.php?rid=5505943&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005344%2Fabstract%3Frss%3Dyes Background & Aims: Hepatitis C virus (HCV) coinfection is one of the leading causes of mortality in human immunodeficiency virus-infected patients. The current standard of care leads to cure only in a part of these patients. The course of the disease is determined by the rapidity of liver fibrosis progression (LFP). The influence of interferon on LFP in coinfected patients has yet not been evaluated by comparative liver biopsies.Methods: We extracted data of patients who had serial liver biopsies from a hospital database. Histopathological findings were compared to factors possibly linked to fibrosis progression. Furthermore, we studied the impact of response to interferon treatment on fibrosis progression.Results: Hundred and twenty-six patients were included, 68 had received anti-HCV tre... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505943 Wed, 20 Jul 2011 04:00:00 +0100 5505943 m-TOR inhibitors: What role in liver transplantation? http://www.medworm.com/index.php?rid=5423064&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005174%2Fabstract%3Frss%3Dyes The development of calcineurin inhibitors (CNIs) led to marked improvements in patient and graft survival after liver transplantation (LTx). We have been left, however, with a dependence on immunosuppressive agents with nephrotoxicity, neurotoxicity, adverse impacts on cardiac risk profile, and risk for malignancy. These challenges need to be met against a dominance of hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) as indications for liver transplant. Unmet needs for immunosuppression (IS) in LTx include:(1) Effective drugs that avoid CNIs toxicities.(2) Agents without adverse impact on HCV recurrence.(3) Compounds that minimize risk of HCC recurrence.New immunosuppressives will need to address the above needs while supporting patient and graft survival equivalent to those achi... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423064 Wed, 20 Jul 2011 04:00:00 +0100 5423064 The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver http://www.medworm.com/index.php?rid=5423061&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005563%2Fabstract%3Frss%3Dyes Conclusions: APOC3 genotype is not associated with progressive liver damage in Caucasian patients with NAFLD. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423061 Wed, 20 Jul 2011 04:00:00 +0100 5423061 m-TOR inhibitors: What role in liver transplantation? http://www.medworm.com/index.php?rid=5409488&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811005174%2Fabstract%3Frss%3Dyes The development of calcineurin inhibitors (CNIs) led to marked improvements in patient and graft survival after liver transplantation (LTx). We have been left, however, with a dependence on immunosuppressive agents with nephrotoxicity, neurotoxicity, adverse impacts on cardiac risk profile, and risk for malignancy. These challenges need to be met against a dominance of hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) as indications for liver transplant. Unmet needs for immunosuppression (IS) in LTx include:(1) Effective drugs that avoid CNIs toxicities.(2) Agents without adverse impact on HCV recurrence.(3) Compounds that minimize risk of HCC recurrence.New immunosuppressives will need to address the above needs while supporting patient and graft survival equivalent to those achi... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5409488 Wed, 20 Jul 2011 04:00:00 +0100 5409488 The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver http://www.medworm.com/index.php?rid=5409485&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811005563%2Fabstract%3Frss%3Dyes Conclusions: APOC3 genotype is not associated with progressive liver damage in Caucasian patients with NAFLD. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5409485 Wed, 20 Jul 2011 04:00:00 +0100 5409485 Reply to: “Herbal medicine hepatotoxicity revisited” http://www.medworm.com/index.php?rid=5598747&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005514%2Fabstract%3Frss%3Dyes The author’s letter states that the mention of some instances of herbal medicines is immaterial in the context of the article’s discussion. We do not agree with this view for the following reasons. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598747 Mon, 18 Jul 2011 04:00:00 +0100 5598747 Caspase-cleaved keratin 18 as a biomarker for non-alcoholic steatohepatitis (NASH) – The need for correct terminology http://www.medworm.com/index.php?rid=5423069&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005502%2Fabstract%3Frss%3Dyes A recent study by Tamimi et al. reported quantification of the levels of two apoptotic markers in the circulation of patients suffering from non-alcoholic steatohepatitis (NASH): “caspase 3 generated cytokeratin-18 fragments” and soluble Fas (sFas). The combined use of these markers was reported to accurately predict the presence of NASH, “supporting the potential usefulness of these markers in clinical practice for noninvasive diagnosis of NASH”. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423069 Mon, 18 Jul 2011 04:00:00 +0100 5423069 Reply to: “NKT cells in liver fibrosis: Controversies or complexities” http://www.medworm.com/index.php?rid=5324581&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811005484%2Fabstract%3Frss%3Dyes Emerging attention has been paid to the role of natural killer T (NKT) cells in a variety of liver diseases including nonalcoholic steatohepatitis (NASH) . The role of NKT cells in hepatic fibrogenesis, however, has been controversial . In our latest manuscript entitled “CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice”, we demonstrated that CD1d-restricted natural killer (NK) T cells play an exacerbating role in xenobiotics-induced liver injury and subsequent fibrogenesis using CD1d-knockout (KO) mice . As Dr. Hua Wang et al. pointed out in their letter, however, the functions of NKT cells in liver pathophysiology appear to be more complex in nature. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5324581 Mon, 18 Jul 2011 04:00:00 +0100 5324581 NKT cells in liver fibrosis: Controversies or complexities http://www.medworm.com/index.php?rid=5324580&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811005472%2Fabstract%3Frss%3Dyes We read with great interest a recent article in the Journal of Hepatology by Ishikawa et al. investigating the role of CD1d-restricted natural killer T (NKT) cells in thioacetamide (TAA)-induced liver fibrosis, by using CD1d knockout (KO) mice that are associated with NKT cell deficiency . First, the authors observed that CD1d KO mice were resistant to TAA-induced liver inflammation, damage, and hepatocyte apoptosis. Second, the authors observed CD1d KO mice were resistant to TAA-induced liver fibrosis, indicating that NKT cells play an important role in promoting liver fibrogenesis in mice after chronic TAA treatment. The pro-fibrotic effects of NKT cells were also recently suggested by the data from a murine model of HBV transgenic mice , primary biliary cirrhosis , nonalcoholic steatohe... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5324580 Mon, 18 Jul 2011 04:00:00 +0100 5324580 Focus http://www.medworm.com/index.php?rid=5324546&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS016882781100554X%2Fabstract%3Frss%3Dyes This Focus article highlights three unrelated studies, the first exploring the role of gene polymorphism in risk of spontaneous bacterial peritonitis (SBP) (“Nature”), the inhibitory activity of a grapefruit flavonoid on hepatitis C virus (HCV) replication (“Natural”), and the role of multipotent stromal cells in correcting defects in a mouse fatty liver disease model (“NAFLD”). (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5324546 Mon, 18 Jul 2011 04:00:00 +0100 5324546 Contents http://www.medworm.com/index.php?rid=5031180&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811003011%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5031180 Sat, 16 Jul 2011 17:16:06 +0100 5031180 EASL vi http://www.medworm.com/index.php?rid=5031179&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811002996%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5031179 Sat, 16 Jul 2011 17:16:06 +0100 5031179 EASL Premium Sponsors http://www.medworm.com/index.php?rid=5031178&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811002984%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5031178 Sat, 16 Jul 2011 17:16:06 +0100 5031178 EASL Clinical School, Venice, Italy http://www.medworm.com/index.php?rid=5031177&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811002972%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5031177 Sat, 16 Jul 2011 17:16:06 +0100 5031177 EASL Short-Term Fellowship http://www.medworm.com/index.php?rid=5031176&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811002960%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5031176 Sat, 16 Jul 2011 17:16:06 +0100 5031176 Editorial Board http://www.medworm.com/index.php?rid=5031175&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.jhep-elsevier.com%2Farticle%2FPIIS0168827811002959%2Fabstract%3Frss%3Dyes (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5031175 Sat, 16 Jul 2011 17:16:06 +0100 5031175 Ammonia and cerebral water. Importance of structural analysis of the brain in hepatic encephalopathy http://www.medworm.com/index.php?rid=5598748&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005459%2Fabstract%3Frss%3Dyes We read with interest the article by Mardini and colleagues , who induced hyperammonaemia experimentally in patients with cirrhosis. They show an increase in apparent diffusion coefficient (ADC) reported on diffusion tensor MR imaging (DTI) of the brain and a decrease in frontal white matter (FWM) myo-inositol (mI) demonstrated on concurrent 1H MR spectroscopy (MRS). These imaging abnormalities were reported in the absence of a change in cognitive status of the patients longitudinally across the study. The authors conclude that this is further evidence of compensated, low grade cerebral oedema in minimal hepatic encephalopathy (MHE), but we would caution against this firm conclusion in MHE patients, because the accumulated published data are uncertain, owing to a lack of direct structural ... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598748 Fri, 15 Jul 2011 04:00:00 +0100 5598748 The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies http://www.medworm.com/index.php?rid=5598735&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005356%2Fabstract%3Frss%3Dyes Conclusions: Carriage of the SOD2 C47T polymorphism is associated with more advanced fibrosis in NASH. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598735 Wed, 13 Jul 2011 04:00:00 +0100 5598735 The changing scenario of hepatocellular carcinoma over the last two decades in Italy http://www.medworm.com/index.php?rid=5598728&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005319%2Fabstract%3Frss%3Dyes Conclusions: Over the last 20years, several aetiologic and clinical features regarding HCC have changed. The survival improvement observed until 2001 was due to an increasing number of tumours diagnosed in early stages and in a background of compensated cirrhosis, and a growing and better use of locoregional treatments. However, the prevalence of early cancers and survival did not increase further in the last years, a result inciting national policies aimed at implementing surveillance programmes for at risk patients. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598728 Wed, 13 Jul 2011 04:00:00 +0100 5598728 Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence http://www.medworm.com/index.php?rid=5598726&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005393%2Fabstract%3Frss%3Dyes Conclusions: ULBP1 is prevalently expressed in DN to mod-HCC, but loss of its expression correlates with tumor progression and early recurrence. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598726 Wed, 13 Jul 2011 04:00:00 +0100 5598726 Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice http://www.medworm.com/index.php?rid=5598724&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS016882781100537X%2Fabstract%3Frss%3Dyes Conclusions: Lack of Abcc3 expression markedly impairs liver growth in response to BA and after PH. Our data suggest that Mrp3 plays a non-redundant role in the regulation of BA flux during liver regeneration. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598724 Wed, 13 Jul 2011 04:00:00 +0100 5598724 HO-1–STAT3 axis in mouse liver ischemia/reperfusion injury: Regulation of TLR4 innate responses through PI3K/PTEN signaling http://www.medworm.com/index.php?rid=5598723&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005289%2Fabstract%3Frss%3Dyes Conclusions: These findings underscore the role of HO-1 induced STAT3 in modulating PI3K/PTEN in liver IRI cascade. Activating PI3K/Akt provides negative feedback mechanism for TLR4-driven inflammation. Identifying molecular pathways of STAT3 modulation in the innate immune system provides the rationale for novel therapeutic approaches for the management of liver inflammation and IRI in transplant patients. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598723 Wed, 13 Jul 2011 04:00:00 +0100 5598723 Hyporesponsiveness to PegIFNα2B plus ribavirin in patients with hepatitis C-related advanced fibrosis http://www.medworm.com/index.php?rid=5598720&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005277%2Fabstract%3Frss%3Dyes Conclusions: Liver fibrosis was an independent moderator of treatment outcome in patients receiving PegIFNα2b, not in those receiving PegIFNα2a. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598720 Wed, 13 Jul 2011 04:00:00 +0100 5598720 A multi-disciplinary approach to treating hepatitis C with interferon and ribavirin in alcohol-dependent patients with ongoing abuse http://www.medworm.com/index.php?rid=5598719&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005253%2Fabstract%3Frss%3Dyes Conclusions: A multidisciplinary approach allowed HCV treatment in alcohol-dependent patients with a satisfactory SVR rate and positive effects on addiction behavior. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598719 Wed, 13 Jul 2011 04:00:00 +0100 5598719 Gaps in the achievement of effectiveness of HCV treatment in national VA practice http://www.medworm.com/index.php?rid=5598717&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005381%2Fabstract%3Frss%3Dyes Conclusions: Treatment effectiveness for HCV is low. In addition to fixed factors, such as race and virus genotype, the drop in effectiveness is due to low rates of antiviral treatment initiation and treatment completion. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598717 Wed, 13 Jul 2011 04:00:00 +0100 5598717 Serum proteomic analysis revealed diagnostic value of hemoglobin for nonalcoholic fatty liver disease http://www.medworm.com/index.php?rid=5505968&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005320%2Fabstract%3Frss%3Dyes Conclusions: Our study showed that serum hemoglobin may have significant predictive value for NAFLD. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505968 Wed, 13 Jul 2011 04:00:00 +0100 5505968 Rho inhibitor prevents ischemia–reperfusion injury in rat steatotic liver http://www.medworm.com/index.php?rid=5505956&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005265%2Fabstract%3Frss%3Dyes Conclusions: Activation of Rho/Rho-kinase signaling in hepatic stellate cells isolated from steatotic livers is associated with an increased susceptibility to ischemia–reperfusion injury. A Rho-kinase inhibitor attenuated the activation of hepatic stellate cells isolated from steatotic livers and improved ischemia–reperfusion injury in steatotic rats. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505956 Wed, 13 Jul 2011 04:00:00 +0100 5505956 Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia–reperfusion http://www.medworm.com/index.php?rid=5505955&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005307%2Fabstract%3Frss%3Dyes Conclusions: SK2 plays an important role in mitochondrial dysfunction, inflammation responses, hepatocyte death, and survival after hepatic IR and represents a new target for the treatment of IR injury. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505955 Wed, 13 Jul 2011 04:00:00 +0100 5505955 Rapid early HDV RNA decline in the peripheral blood but prolonged intrahepatic hepatitis delta antigen persistence after liver transplantation http://www.medworm.com/index.php?rid=5505952&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005332%2Fabstract%3Frss%3Dyes Conclusions: HDV RNA and HBsAg decline follow almost identical kinetic patterns within the first days after LTX. Nevertheless, intrahepatic latency of HDAg has to be considered when exploring novel concepts to withdraw HBIG. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505952 Wed, 13 Jul 2011 04:00:00 +0100 5505952 Survival comparison between surgical resection and radiofrequency ablation for patients in BCLC very early/early stage hepatocellular carcinoma http://www.medworm.com/index.php?rid=5598730&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005241%2Fabstract%3Frss%3Dyes Background & Aims: To compare the survival between surgical resection (SR) and radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC) in Barcelona Clinic Liver Cancer (BCLC) very early/early stage.Methods: Between 2002 and 2009, patients with newly diagnosed BCLC very early/early stage HCC who received SR or RFA were enrolled. Medical records were reviewed. The cumulative overall survival (OS) and disease-free survival (DFS) were compared.Results: A total of 605 patients, including 143 very early (SR: 52; RFA: 91) and 462 early stages (SR: 208; RFA: 254) were enrolled. For very early stage, the 3- and 5-year OS rates were 98% and 91.5% for SR, and 80.3% and 72% for RFA, respectively (p=0.073). The 3- and 5-year DFS rates were 62.1% and 40.7% for SR, and 39.8% and 29.... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598730 Tue, 12 Jul 2011 04:00:00 +0100 5598730 FGL2/Fibroleukin mediates hepatic reperfusion injury by induction of sinusoidal endothelial cell and hepatocyte apoptosis in mice http://www.medworm.com/index.php?rid=5505957&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS016882781100540X%2Fabstract%3Frss%3Dyes Conclusions: FGL2 binding to the FcγRIIB receptor expressed on SEC is a critical event in the initiation of the hepatic reperfusion injury cascade through induction of SEC and hepatocyte death. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505957 Tue, 12 Jul 2011 04:00:00 +0100 5505957 Midodrine in patients with cirrhosis and refractory or recurrent ascites: A randomized pilot study http://www.medworm.com/index.php?rid=5598721&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005228%2Fabstract%3Frss%3Dyes Background & Aims: Splanchnic arterial vasodilatation plays an important role in cirrhotic ascites. The aim of this study was to evaluate the effects of long term administration of midodrine on systemic hemodynamics, renal function, and control of ascites in patients with cirrhosis and refractory or recurrent ascites.Methods: Forty cirrhotic patients with refractory or recurrent ascites were prospectively studied after long term administration of midodrine plus standard medical therapy (n=20) or standard medical therapy alone (n=20) in a randomized controlled trial at a tertiary centre.Results: A significant increase in urinary volume, urinary sodium excretion, mean arterial pressure, and decrease in plasma renin activity (p (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5598721 Mon, 11 Jul 2011 04:00:00 +0100 5598721 Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma http://www.medworm.com/index.php?rid=5505959&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005216%2Fabstract%3Frss%3Dyes Background & Aims: Several groups have reported the significance of circulating microRNA as a biochemical marker of cancer. To our knowledge, however, there are no reports on the significance of circulating microRNA in hepatocellular carcinoma. The aim of this study was to evaluate the significance of plasma microRNA-21 level as a biochemical marker for hepatocellular carcinoma.Methods: Plasma microRNA-21 level was measured by qRT-PCR in 10 patients before and after curative resection of hepatocellular carcinoma. Plasma microRNA-21 was also compared in other groups of: 126 patients with hepatocellular carcinoma, 30 patients with chronic hepatitis, and 50 healthy volunteers. The power of microRNA-21 in differentiating hepatocellular carcinoma from chronic hepatitis or from healthy volunteer... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505959 Mon, 11 Jul 2011 04:00:00 +0100 5505959 Mutation in the mitochondrial translation elongation factor EFTs results in severe infantile liver failure http://www.medworm.com/index.php?rid=5505978&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005162%2Fabstract%3Frss%3Dyes Conclusions: This mutation has been previously reported in two unrelated kindred presenting two distinct syndromes (fatal mitochondrial encephalomyopathy and hypertrophic cardiomyopathy respectively). The description of a third syndrome associated with a same TSFM mutation gives support to the broad clinical and genetic heterogeneity of mitochondrial translation deficiencies in human. It suggests that mitochondrial translation deficiency represents a growing cause of hepatic failure of mitochondrial origin in infants. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505978 Fri, 08 Jul 2011 04:00:00 +0100 5505978 Lipotoxicity in NASH http://www.medworm.com/index.php?rid=5505977&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005137%2Fabstract%3Frss%3Dyes Exposure to a sedentary lifestyle, fat-rich and fiber-poor diets, positive caloric imbalance and an extended life disrupt the metabolic homeostasis causing non-alcoholic fatty liver disease. A subset of patients with this emerging public health problem may develop non-alcoholic steatohepatitis (NASH) and progress to cirrhosis and liver cancer . Understanding the molecular mechanisms promoting liver injury in NASH is not only of biomedical and public health interest, but also key to develop new avenues for specific treatment interventions. In this Snapshot article, we will outline current evolving concepts of signaling cascades that may be linked to liver injury in NASH. It is important to acknowledge that a significant amount of information has been obtained from in vitro and animal studie... Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505977 Fri, 08 Jul 2011 04:00:00 +0100 5505977 The use of Sirolimus should be restricted in liver transplantation http://www.medworm.com/index.php?rid=5505976&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005149%2Fabstract%3Frss%3Dyes Sirolimus (rapamycin) has potent immunosuppressive properties related to inhibition of the mammalian target of rapamycin (mTOR) . Sirolimus, with cyclosporin and steroids, reduced the incidence of acute rejection in kidney transplant recipients , leading to approval for use in renal transplantation by the Federal Food & Drug Administration (FDA) in 1999. The absence of intrinsic nephrotoxicity made Sirolimus an attractive alternative to calcineurin inhibitors (CNIs), which has led to off-label use in combination with other agents in liver transplantation, but increased experience has revealed serious toxicity. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5505976 Fri, 08 Jul 2011 04:00:00 +0100 5505976 Can serotonin agonists unlock age-dependent failure of liver regeneration? http://www.medworm.com/index.php?rid=5423066&cid=s_38513_17_f&fid=38513&url=http%3A%2F%2Fwww.journal-of-hepatology.eu%2Farticle%2FPIIS0168827811005113%2Fabstract%3Frss%3Dyes COMMENTARY ON: Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway. Furrer K, Rickenbacher A, Tian Y, Jochum W, Bittermann AG, Käch A, Humar B, Graf R, Moritz W, Clavien PA. Proc Natl Acad Sci USA. 2011 Feb 15;108(7):2945–2950. Copyright (2011). Abstract reprinted with the permission of the National Academy of Sciences of the United States of America. (Source: Journal of Hepatology) Journal of Hepatology journals http://www.medworm.com/rss/comments.php?id=5423066 Thu, 07 Jul 2011 04:00:00 +0100 5423066