Journal of Internal Medicine via MedWorm.com

Whole blood cytokine attenuation by cholinergic agonists ex vivo and relationship to vagus nerve activity in rheumatoid arthritis

Journal of Internal Medicine — Sat, 20 Mar 2010 00:00:00 +0100

Conclusion. These findings suggest that it is possible to pharmacologically target the [alpha]7nAChR dependent control of cytokine release in RA patients with suppressed vagus nerve activity. As [alpha]7nAChR agonists ameliorate the clinical course of collagen induced arthritis in animals, it may be possible in the future to explore whether [alpha]7nAChR agonists can improve clinical activity in RA patients. (Source: Journal of Internal Medicine)

Profound cardiac conduction delay predicts mortality in myotonic dystrophy type 1

Journal of Internal Medicine — Thu, 11 Mar 2010 00:00:00 +0100

Conclusions. These findings suggest that silent cardiac dysfunction in DM1 patients may cause significant disturbances that over time result in serious complications. Regular follow-up of such patients with detailed electrical and mechanical cardiac assessment may suggest a need for early intervention that may avoid early mortality in some. (Source: Journal of Internal Medicine)

Identifying women with severe angiographic coronary disease

Journal of Internal Medicine — Fri, 05 Mar 2010 00:00:00 +0100

Conclusions. Women referred for first diagnostic angiography have lower rates of severe CAD compared with men across all ages. Whilst conventional risk factors, age, sex, diabetes, smoking and hyperlipidaemia are primary determinants of CAD amongst women and men, CCS Class IV angina is more likely to be associated with severe CAD in women than men. (Source: Journal of Internal Medicine)

Relation between renal function, presentation, use of therapies and in-hospital complications in acute coronary syndrome: data from the SWEDEHEART register

Journal of Internal Medicine — Thu, 25 Feb 2010 00:00:00 +0100

Conclusion. Renal insufficiency influences the presentation and reduces the likelihood of receiving treatment according to current guidelines. Short-term prognosis remains poor. (Source: Journal of Internal Medicine)

Weak associations between human leucocyte antigen genotype and acute myocardial infarction

Journal of Internal Medicine — Sat, 06 Feb 2010 00:00:00 +0100

Conclusions. This study demonstrates that the associations between HLA-DRB1 and DQA1 loci and cardiovascular disease exists but that they are considerably weaker than those previously reported for other diseases with an established autoimmune aetiology such as type 1 diabetes, systemic lupus erythematosus and rheumatoid arthritis. (Source: Journal of Internal Medicine)

Haemochromatosis genotype and iron overload: association with hypertension and left ventricular hypertrophy

Journal of Internal Medicine — Fri, 29 Jan 2010 00:00:00 +0100

Ellervik C, Tybjærg-Hansen A, Appleyard M, Ibsen H, Nordestgaard BG (Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Herlev; Næstved Hospital, University of Copenhagen, Naestved; Copenhagen University Hospital, University of Copenhagen, Copenhagen East; Bispebjerg Hospital, Copenhagen University Hospital, University of Copenhagen, Bispebjerg; and Holbaek Hospital, Holbaek; Denmark). Haemochromatosis genotype and iron overload: association with hypertension and left ventricular hypertrophy. J Intern Med 2010; doi: 10.1111/j.1365-2796.2010.02217.x.Objective. We hypothesized that there is an association between haemochromatosis genotype C282Y/C282Y and/or iron overload and risk of hypertension and/or left ventricular hypertrophy (LVH).Methods. We analysed data fro...

Energy regulation and neuroendocrine–immune control in chronic inflammatory diseases

Journal of Internal Medicine — Thu, 28 Jan 2010 00:00:00 +0100

Abstract.Straub RH, Cutolo M, Buttgereit F, Pongratz G (University Hospital Regensburg, Regensburg, Germany; University of Genova, Genova, Italy; and Charité University Medicine Berlin, Berlin, Germany). Energy regulation and neuroendocrine[ndash]immune control in chronic inflammatory diseases (Review). J Intern Med 2010; doi:10.1111/j.1365-2796.2010.02218.x Energy regulation (EnR) is most important for homoeostatic regulation of physiological processes. Neuroendocrine pathways are involved in EnR. We can separate factors that provide energy-rich fuels to stores [parasympathetic nervous system (PSNS), insulin, insulin-like growth factor-1, oestrogens, androgens and osteocalcin] and those that provide energy-rich substrates to consumers [sympathetic nervous system (SNS), hypothalamic[ndash...

Weight change in later life and risk of death amongst the elderly: the European Prospective Investigation into Cancer and Nutrition-Elderly Network on Ageing and Health study

Journal of Internal Medicine — Thu, 28 Jan 2010 00:00:00 +0100

Abstract. Bamia C, Halkjær J, Lagiou P, Trichopoulos D, Tjønneland A, Berentzen TL, Overvad K, Clavel-Chapelon F, Boutron-Ruault M-C, Rohrmann S, Linseisen J, Steffen A, Boeing H, May AM, Peeters PH, Bas Bueno-de-Mesquita H, van den Berg SW, Dorronsoro M, Barricarte A, Rodriguez Suarez L, Navarro C, González CA, Boffetta P, Pala V, Hallmans G, Trichopoulou A (University of Athens, Athens, Greece; Institute of Cancer Epidemiology, Copenhagen, Denmark; Harvard School of Public Health, Boston, MA, USA; Bureau of Epidemiologic Research, Athens, Greece; Hellenic Health Foundation, Athens, Greece; Institute of Preventive Medicine, Copenhagen, Denmark; Institute of Public Health, Aarhus University, Aarhus, Denmark; Center for Cardiovascular Research, Aalborg, Denmark; Institut Gustave-Roussy, ...

Cystatin C and risk of vascular and nonvascular mortality: a prospective cohort study of older men

Journal of Internal Medicine — Wed, 20 Jan 2010 00:00:00 +0100

Abstract. Emberson JR, Haynes R, Dasgupta T, Mafham M, Landray MJ, Baigent C, Clarke R (University of Oxford, Oxford, UK). Cystatin C and risk of vascular and nonvascular mortality: a prospective cohort study of older men. J Intern Med 2010; doi: 10.1111/j.1365-2796.2010.02214.x.Objective. To assess the relevance of cystatin C, as a marker of mild-to-moderate renal impairment, for vascular and nonvascular mortality in older people.Design. Prospective cohort study.Setting. Re-survey in 1997 to 1998 of survivors in the 1970 Whitehall study of London civil servants.Subjects. Five thousand three hundred and seventy-one men (mean age at resurvey: 77 years) who took part in the resurvey and had plasma cystatin C concentration measured.Main outcome measures. Cause-specific mortality over subseque...

Effect of gender on prognosis in patients with myocardial infarction and type 2 diabetes

Journal of Internal Medicine — Wed, 20 Jan 2010 00:00:00 +0100

Conclusions. Age and not gender itself explained the increased cardiovascular event rate seen in women compared with men. A heavier risk factor burden was seen amongst women. Improved risk factor control instituted before the development of a myocardial infarction should be attempted as a possible means of improving the outcome. (Source: Journal of Internal Medicine)

Worse blood pressure control in patients with cerebrovascular or peripheral arterial disease compared with coronary artery disease

Journal of Internal Medicine — Wed, 25 Nov 2009 00:00:00 +0100

Abstract. Mechtouff L, Touzé E, Steg PG, Ohman EM, Goto S, Hirsch AT, Röther J, Aichner FT, Weimar C, Bhatt DL, Alberts MJ, Mas J-L, on behalf of the REACH Registry Investigators (Paris-Descartes University; Université Paris 7; Paris, France, Duke University, Durham NC, USA, Tokai University, Isehara, Japan, University of Minnesota, Minneapolis, MN, USA, Academic Teaching Hospital Hannover Medical School, Minden, Germany, Academic Teaching Hospital Wagner-Jauregg, Linz, Austria, University of Duisburg-Essen, Essen, Germany, VA Boston Healthcare System, and Brigham and Women's Hospital, Boston, MA; and Northwestern University Medical School, Chicago, IL; USA). Worse blood pressure control in patients with cerebrovascular or peripheral arterial disease compared with coronary artery diseas...

Risk factors for end-stage renal disease in a community-based population: 26-year follow-up of 25 821 men and women in eastern Finland

Journal of Internal Medicine — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion. The findings of the present study confirm that modifiable risk factors play a major role in the development of ESRD in the North-European population. People with diabetes, hypertension or obesity should be considered as the target groups when planning preventive measures to control the future epidemic of ESRD. (Source: Journal of Internal Medicine)

Job strain predicts recurrent events after a first acute myocardial infarction: the Stockholm Heart Epidemiology Program

Journal of Internal Medicine — Tue, 17 Nov 2009 00:00:00 +0100

Conclusions. Job strain was associated with poor long-term prognosis after a first myocardial infarction. Interventions focusing on reducing stressors at the workplace or on improving coping with work stress in cardiac patients might improve their survival post-AMI. (Source: Journal of Internal Medicine)

Menopause impacts the relation of plasma adiponectin levels with the metabolic syndrome

Journal of Internal Medicine — Fri, 13 Nov 2009 00:00:00 +0100

Conclusions. Low plasma levels of adiponectin are associated with increased prevalence of MetS, especially in postmenopausal women. Age and BMI have similar discriminatory accuracies for presence of MetS when compared with age and plasma adiponectin. Thus, we conclude that the association of plasma adiponectin with MetS is significantly affected by menopause but challenge the additional value of adiponectin for the discriminatory accuracy for presence of MetS. (Source: Journal of Internal Medicine)

Osteoprotegerin concentrations and prognosis in acute ischaemic stroke

Journal of Internal Medicine — Sat, 07 Nov 2009 00:00:00 +0100

Conclusion. Osteoprotegerin concentrations measured at admission of acute ischaemic stroke are associated with long-term mortality. (Source: Journal of Internal Medicine)

Impact of waist circumference versus adiponectin level on subclinical atherosclerosis

Journal of Internal Medicine — Wed, 04 Nov 2009 00:00:00 +0100

Abstract. Holewijn S, den Heijer M, van Tits LJ, Swinkels DW, Stalenhoef AFH, de Graaf J (Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands). Impact of waist circumference versus adiponectin level on subclinical atherosclerosis. A cross-sectional analysis in a sample from the general population. J Intern Med 2010; 00: 000[ndash]000.Objective. Waist circumference is a clinical marker of obesity and an established risk factor for cardiovascular (CV) disease. Adiponectin, an adipocyte-derived hormone and new biomarker of obesity, was recently proposed as the missing link between obesity and increased cardiovascular risk. We evaluated waist and adiponectin in a middle-aged population-based cohort to compare the impact of both obesity-markers on subclinical atherosclerosis, ...

Gender difference of association between LDL cholesterol concentrations and mortality from coronary heart disease amongst Japanese: the Ibaraki Prefectural Health Study

Journal of Internal Medicine — Mon, 26 Oct 2009 00:00:00 +0100

Abstract. Noda H, Iso H, Irie F, Sairenchi T, Ohtaka E, Ohta H (Osaka University, Osaka, Japan; Harvard School of Public Health, Cambridge, MA, USA; Ibaraki Prefectural Office, Ibaraki; Dokkyo Medical University School of Medicine, Tochigi; Ibaraki Health Service Association, Ibaraki; Japan). Gender difference of association between LDL cholesterol concentrations and mortality from coronary heart disease amongst Japanese: the Ibaraki Prefectural Health Study. J Intern Med 2010;00: 000[ndash]000Objective. The aim of this study was to examine whether LDL cholesterol raises the risk of coronary heart disease in a dose[ndash]response fashion in a population with low LDL-cholesterol levels.Design. Population-based prospective cohort study in Japan.Subjects and main outcome measures. A total of ...

Predictive value of on-treatment response during full-dose antiviral therapy of patients with hepatitis C virus cirrhosis and portal hypertension

Journal of Internal Medicine — Wed, 21 Oct 2009 23:00:00 +0100

Conclusion. Full-dose antiviral therapy with PEG-IFN and ribavirin can be safely carried out even in patients with compensated, fully established cirrhosis and portal hypertension. Selecting patients on the basis of HCV genotype and viral load, and application of on-treatment stopping rule may help rationalize treatment in patients who are unlikely to obtain SVR. (Source: Journal of Internal Medicine)

No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year

Journal of Internal Medicine — Mon, 19 Oct 2009 00:00:00 +0100

Conclusions. Our results do not support a positive effect of vitamin D on glucose tolerance, blood pressure or serum lipids. Further studies in subjects with low serum 25(OH)D levels combined with impaired glucose tolerance, hypertension or dyslipidaemia are needed. (Source: Journal of Internal Medicine)

Cardiovascular outcomes and their relationships to lipoprotein components in patients with and without chronic kidney disease: results from the IDEAL trial

Journal of Internal Medicine — Tue, 13 Oct 2009 00:00:00 +0100

Abstract. Holme I, Fayyad R, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Larsen ML, Lindahl C, Holdaas H, Pedersen TR, On behalf of the Incremental Decrease in End Points Through Aggressive Lipid Lowering Study Group (Centre of Preventive Medicine, Oslo, Norway; Århus University Hospital, Århus, Denmark; Academic Hospital Amsterdam, Amsterdam, The Netherlands; University Hospital, Linköping, Sweden; Helsinki University Central Hospital, Helsinki, Finland; Oslo University Hospital, Rikshospitalet, Oslo, Norway; Pfizer Sweden, Sollentuna, Sweden; and Pfizer Inc., New York, NY, USA). Cardiovascular outcomes and their relationships to lipoprotein components in patients with and without chronic kidney disease: Results from the IDEAL trial. J Intern Med 2010;00: 000[ndash]000 Objectiv...

GRB10 gene and type 2 diabetes in Whites

Journal of Internal Medicine — Sat, 10 Oct 2009 23:00:00 +0100

(Source: Journal of Internal Medicine)

Long-term effects of weight loss with a very low carbohydrate and low fat diet on vascular function in overweight and obese patients

Journal of Internal Medicine — Tue, 06 Oct 2009 00:00:00 +0100

Conclusion. Both LC and LF hypoenergetic diets achieved similar reductions in body weight and were associated with improvements in PWV and a number of endothelium-derived factors. However, the LC diet impaired FMD suggesting chronic consumption of a LC diet may have detrimental effects on endothelial function. (Source: Journal of Internal Medicine)

Circulating high molecular weight adiponectin isoform is heritable and shares a common genetic background with insulin resistance in nondiabetic White Caucasians from Italy: evidence from a family-based study

Journal of Internal Medicine — Wed, 16 Sep 2009 23:00:00 +0100

Conclusion. Circulating levels of adiponectin isoforms are highly heritable. The genetic control of HMW adiponectin is shared in part with insulin resistance-related traits and involves, but is not limited to, the ADIPOQ locus. (Source: Journal of Internal Medicine)

Effects of atorvastatin on circulating CD34+/CD133+/ CD45− progenitor cells and indices of angiogenesis (vascular endothelial growth factor and the angiopoietins 1 and 2) in atherosclerotic vascular disease and diabetes mellitus

Journal of Internal Medicine — Mon, 14 Sep 2009 23:00:00 +0100

Conclusion. High-dose atorvastatin increased circulating CPCs, reduced VEGF and increased Ang-2 in patients with diabetes and CVD, providing another possible pathophysiological mechanism for the beneficial effects of statins in CVD. (Source: Journal of Internal Medicine)

Impact of a high-dose nitrate strategy on cardiac stress in acute heart failure: a pilot study

Journal of Internal Medicine — Mon, 17 Aug 2009 23:00:00 +0100

Conclusions. A noninvasive high-dose nitrate strategy on top of standard therapy is safe and notably accelerates cardiac recovery in patients observed on the general ward. (Source: Journal of Internal Medicine)

Consistency of blood pressure and impact on cardiovascular structure over 20 years in young men

Journal of Internal Medicine — Sat, 04 Jul 2009 23:00:00 +0100

Conclusions. BP elevation in young age predicts hypertension and adverse cardiovascular remodelling at the age of 40 years. Baseline office MAP is the best predictor of hypertension, 24-h MAP and LVMI. (Source: Journal of Internal Medicine)

Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns Study

Journal of Internal Medicine — Tue, 30 Jun 2009 23:00:00 +0100

Conclusions. Serum amyloid A was associated with several metabolic risk factors but was not an independent predictor of IMT or carotid artery compliance. Further longitudinal studies will show whether SAA holds a prognostic value as a risk marker, analogously to CRP. (Source: Journal of Internal Medicine)

NOD2/CARD15 genotype and common gastrointestinal diseases in 43 600 individuals

Journal of Internal Medicine — Mon, 29 Jun 2009 23:00:00 +0100

Conclusions. NOD2/CARD15 polymorphisms are not major risk factors for common gastrointestinal diseases; however, we cannot completely exclude association with appendicitis, anal fissure, fistula and abscess, and gastrointestinal cancer. (Source: Journal of Internal Medicine)

Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes

Journal of Internal Medicine — Fri, 26 Jun 2009 23:00:00 +0100

Abstract. Abstract. Fyhrquist F, Tiitu A, Saijonmaa O, Forsblom C, Groop P-H, on behalf of the FinnDiane Study Group (Minerva Institute for Medical Research; Helsinki University Central Hospital; and Folkhälsan Institute of Genetics; Helsinki, Finland). Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes. J Intern Med 2009;doi: 10.1111/j.1365-2796.2009.02139.x.Objectives. To determine whether short telomere length of blood leucocytes from patients with type 1 diabetes is associated with or predictive of progression of diabetic nephropathy.Design and methods. Two consecutive DNA samples were obtained from 132 patients from the nationwide Finnish Diabetic Nephropathy Study with type 1 diabetes. Control DNA samples were taken from 44 healthy blood donors....

Follow-ups of the Cardiovascular Risk in Young Finns Study in 2001 and 2007: Levels and 6-year changes in risk factors

Journal of Internal Medicine — Wed, 24 Jun 2009 23:00:00 +0100

Conclusions. The 6-year changes in total cholesterol, LDL-cholesterol and HDL-cholesterol in young Finns were favourable between 2001 and 2007. However, waist circumference, glucose and blood pressure levels increased. Therefore, continuous efforts are still needed in fighting against cardiovascular risk factors. (Source: Journal of Internal Medicine)

Vaccinate your child and save its grandparents from a heart attack? Current perspectives in antipneumococcal vaccination

Journal of Internal Medicine — Wed, 24 Jun 2009 23:00:00 +0100

This study reviews available data on the efficacy of the available vaccines in different age groups and disease presentations, and the advantages and shortcomings of each type of vaccine, including future perspectives. Special attention is given to controversies regarding the efficacy of PPV against pneumonia in adults and its protective effects against myocardial infarction. (Source: Journal of Internal Medicine)

Persistent parvovirus B19 infection detected by specific CD4+ T-cell responses in a patient with hepatitis and polyarthritis

Journal of Internal Medicine — Wed, 24 Jun 2009 23:00:00 +0100

Abstract. Pongratz G, Lindner J, Modrow S, Schimanski S, Schölmerich J, Fleck M (University Medical Center Regensburg, Regensburg; Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg; and Asklepios-Clinic, Bad Abbach; Germany). Persistent parvovirus B19 infection detected by specific CD4+ T-cell responses in a patient with hepatitis and polyarthritis (Case Report). J Intern Med 2009; We, here, report the case of a parvovirus B19 infection in an immunocompetent male patient presenting with acute hepatitis and polyarthritis. To follow the course of infection, we used a previously established enzyme-linked immunosorbent spot assay (ELISPOT) technique to detect CD4+ T cells specific for viral proteins. Even though symptoms of arthritis and hepatitis resolved i...

Clinical significance of low-grade renal artery stenosis

Journal of Internal Medicine — Sun, 21 Jun 2009 23:00:00 +0100

Abstract. Dechering DG, Kruis HME, Adiyaman A, Thien Th, Postma CT (Radboud University, Nijmegen, The Netherlands, and University Hospital Münster, Münster, Germany). Clinical significance of low-grade renal artery stenosis. J Intern Med 2009; doi: 10.1111/j.1365-2796.2009.02144.x.Background. Patients with a renal artery stenosis (RAS) >50% carry an increased risk for future cardiovascular (CV) events. Experimental literature on this topic suggests that this might as well be true for subjects with lower-grade RAS.Methods. Recruitment in this longitudinal cohort study was conducted from 1982 to 2002 in a Dutch University Hospital. Included in this study were 301 hypertensive patients clinically suspected of having RAS. Study participants were radiologically classified as having no, a low-...

An investigation of serum concentration of apoM as a potential MODY3 marker using a novel ELISA

Journal of Internal Medicine — Sun, 21 Jun 2009 23:00:00 +0100

Conclusions. Female carriers of the P291fsinsC mutation in HNF-1[alpha] displayed slightly lower apoM serum levels. This difference is too small for apoM to be reliably employed as a biomarker for HNF-1[alpha] mutation status. (Source: Journal of Internal Medicine)

Kidney function and discrimination of cardiovascular risk in middle-aged men

Journal of Internal Medicine — Fri, 05 Jun 2009 04:00:00 +0100

Conclusion. The GFR cut-off point for optimal discrimination of cardiovascular risk in the general population may be higher than previously suggested. (Source: Journal of Internal Medicine)

A functional variant in the gene 3' untranslated region regulates HSP70 expression and is a potential candidate for insulin resistance-related abnormalities

Journal of Internal Medicine — Sat, 30 May 2009 23:00:00 +0100

(Source: Journal of Internal Medicine)

Comparison of midregional pro-atrial natriuretic peptide with N-terminal pro-B-type natriuretic peptide in the diagnosis of heart failure

Journal of Internal Medicine — Sat, 30 May 2009 23:00:00 +0100

Conclusion. Midregional pro-atrial natriuretic peptide is as accurate in the diagnosis of heart failure as NTproBNP. MRproANP seems to provide incremental information on top of BNP or NT-proBNP in some subgroups and should be further investigated in other studies. (Source: Journal of Internal Medicine)

Fitness and abdominal obesity are independently associated with cardiovascular risk

Journal of Internal Medicine — Sat, 30 May 2009 23:00:00 +0100

Conclusions. Higher fitness and lower waist circumference are each independently associated to a similar extent with a lower CVD risk. Simultaneous evaluation of both fitness and abdominal obesity status in clinical practice is important. (Source: Journal of Internal Medicine)

Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417 734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS)

Journal of Internal Medicine — Mon, 25 May 2009 23:00:00 +0100

Conclusions. Already moderate levels of UA appear to be associated with an increased incidence of AMI, stroke and CHF in middle-aged subjects without prior cardiovascular disease. These associations seem to increase gradually from lower to higher levels of UA. UA may be an important complementary indicator of cardiovascular risk in the general population. (Source: Journal of Internal Medicine)

Obesity and trends in cardiovascular risk factors over 40 years in Swedish men aged 50

Journal of Internal Medicine — Thu, 21 May 2009 04:00:00 +0100

Abstract. Rosengren A, Eriksson H, Hansson PO, Svärdsudd K, Wilhelmsen L, Johansson S, Welin C, Welin L (Sahlgrenska University Hospital/Östra, Göteborg; Uppsala University, University Hospital, Uppsala; AstraZeneca R&D, Mölndal; University of Gothenburg, Institute of Health and Care Sciences, Gothenburg; Lidköping Hospital, Lidköping; Sweden). Obesity and trends in cardiovascular risk factors over 40 years in Swedish men aged 50. J Intern Med 2009; doi: 10.1111/j.1365-2796.2009.02116.xObjective. To study trends over 40 years in cardiovascular risk factors in normal weight, overweight and obese men, all aged 50 when examined.Design. Cross-sectional studies of five successive cohorts of men aged 50.Setting. City of Göteborg, Sweden.Subjects. Random population samples of altogether 32...

Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses

Journal of Internal Medicine — Tue, 19 May 2009 04:00:00 +0100

Conclusions. The response of CFS patients to incremental exercise associates a lengthened and accentuated oxidative stress, which might result from delayed and insufficient Hsp production. (Source: Journal of Internal Medicine)

ANTI-HSP60 and ANTI-HSP70 antibody levels and micro/ macrovascular complications in type 1 diabetes: the EURODIAB Study

Journal of Internal Medicine — Thu, 07 May 2009 23:00:00 +0100

Conclusions. In this large cohort of type 1 diabetic subjects, we found an independent and inverse association between serum anti-HSP70 antibody levels and diabetic micro/macrovascular complications. This suggests that anti-HSP70 antibody levels may be a novel marker of protection from chronic diabetic complications. (Source: Journal of Internal Medicine)

Lipid lowering versus pleiotropic effects of statins on skin microvascular function in patients with dysglycaemia and coronary artery disease

Journal of Internal Medicine — Wed, 06 May 2009 23:00:00 +0100

Conclusions. Lipid lowering improves microvascular function in patients with dysglycaemia and CAD. The data suggest that lipid lowering per se is more important than pleiotropic effects of statins for this effect. (Source: Journal of Internal Medicine)

Apolipoprotein M predicts pre-β-HDL formation: studies in type 2 diabetic and nondiabetic subjects

Journal of Internal Medicine — Mon, 04 May 2009 04:00:00 +0100

Conclusions. Plasma apoM is modestly reduced in type 2 diabetes. Pre-[beta]-HDL and pre-[beta]-HDL formation are positively associated with apoM, supporting the hypothesis that apoM plays a role in HDL remodelling in humans. Lower apoM may provide a mechanism to explain why pre-[beta]-HDL formation is not increased in type 2 diabetes despite elevated PLTP activity. (Source: Journal of Internal Medicine)

25-hydroxyvitamin D accumulation during summer in elderly women at latitude 60ºN

Journal of Internal Medicine — Sun, 26 Apr 2009 23:00:00 +0100

Conclusions. Women with high winter 25(OH)D serum concentrations, with preference of staying in the sun instead of shade during summer, a skin type allowing for longer sun exposure and a normal weight had the highest summer 25(OH)D concentrations. (Source: Journal of Internal Medicine)

Rituximab in auto-immune haemolytic anaemia and immune thrombocytopenic purpura: a Belgian retrospective multicentric study

Journal of Internal Medicine — Sun, 26 Apr 2009 23:00:00 +0100

Conclusions. This study confirms that rituximab induces responses in a majority of previously treated patients with AIHA and ITP. Response duration generally exceeds 1 year. Retreatment with rituximab in responding patients is most often successful. The outcome of patients who fail on rituximab is poor. We were not able to identify pretreatment patient characteristics predicting for response. (Source: Journal of Internal Medicine)

Role of two nutritional hepatic markers (insulin-like growth factor 1 and transthyretin) in the clinical assessment and follow-up of acute intermittent porphyria patients

Journal of Internal Medicine — Wed, 22 Apr 2009 23:00:00 +0100

Conclusions. This first study in humans suggests that the clinical expression AIP is associated with a state of under-nutrition and/or with hepatic inflammation due to the sustained accumulation of heme-precursors. We propose the use of both IGF-1 and transthyretin as biomarkers of disease morbidity/severity for the clinical follow-up of AIP patients. (Source: Journal of Internal Medicine)

Perceived stress as a risk factor for changes in health behaviour and cardiac risk profile: a longitudinal study

Journal of Internal Medicine — Wed, 22 Apr 2009 23:00:00 +0100

Conclusion. This longitudinal study supports a causal relation between stress and cardiovascular diseases mediated through unfavourable changes in health behaviour and cardiac risk profile. (Source: Journal of Internal Medicine)

Influence of statin treatment on platelet inhibition by clopidogrel – a randomized comparison of rosuvastatin, atorvastatin and simvastatin co-treatment

Journal of Internal Medicine — Wed, 22 Apr 2009 23:00:00 +0100

Conclusions. Treatment with CYP3A4 metabolized statins, atorvastatin or simvastatin, did not attenuate the platelet inhibitory effect of clopidogrel maintenance treatment compared with the non-CYP3A4 metabolized, rosuvastatin. (Source: Journal of Internal Medicine)

Prevalence and extent of calcification over aorta, coronary and carotid arteries in patients with rheumatoid arthritis

Journal of Internal Medicine — Wed, 22 Apr 2009 23:00:00 +0100

Conclusions. Our results demonstrated that RA patients had earlier onset, more diffuse arterial calcification over multiple vascular beds and more preferential involvement of thoracic aorta, rather than coronary artery when compared with control. (Source: Journal of Internal Medicine)

Exploring the link between inflammation and the vagus nerve

Journal of Internal Medicine — Fri, 10 Apr 2009 04:00:00 +0100

(Source: Journal of Internal Medicine)

Chocolate consumption and mortality following a first acute myocardial infarction: the Stockholm Heart Epidemiology Program

Journal of Internal Medicine — Fri, 27 Mar 2009 04:00:00 +0100

Conclusions. Chocolate consumption was associated with lower cardiac mortality in a dose dependent manner in patients free of diabetes surviving their first AMI. Although our findings support increasing evidence that chocolate is a rich source of beneficial bioactive compounds, confirmation of this strong inverse relationship from other observational studies or large-scale, long-term, controlled randomized trials is needed. (Source: Journal of Internal Medicine)

Better adherence to antihypertensive agents and risk reduction of chronic heart failure

Journal of Internal Medicine — Wed, 25 Mar 2009 04:00:00 +0100

Conclusion. Our study suggests that a better adherence is associated with a significant risk reduction of CHF. Adherence to AH therapy needs to be improved to optimize benefits. (Source: Journal of Internal Medicine)

Modulating T-cell homeostasis with IL-7: preclinical and clinical studies

Journal of Internal Medicine — Wed, 25 Mar 2009 04:00:00 +0100

Abstract. Capitini CM, Chisti AA, Mackall CL (National Cancer Institute, National Institutes of Health, Bethesda, MD; USA). Modulating T-cell homeostasis with IL-7: preclinical and clinical studies (Review). Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in the setting of disease. (Source: Journal of Internal Medicine)

Use of snus and risk for cardiovascular disease: results from the Swedish Twin Registry

Journal of Internal Medicine — Thu, 12 Mar 2009 04:00:00 +0100

Conclusion. These data do not support any strong association between snus use and risk for cardiovascular disease. (Source: Journal of Internal Medicine)

Intensive lipid lowering may reduce progression of carotid atherosclerosis within 12 months of treatment: the METEOR study

Journal of Internal Medicine — Wed, 04 Mar 2009 05:00:00 +0100

Conclusion. Aggressive LDL-C lowering seems to exert its beneficial effect on atherosclerosis progression during the first 12 months of treatment. This parallels the timing of event reduction seen in clinical trials and suggests that the efficacy of lipid lowering treatment on CIMT progression can be evaluated in trials with a duration of 1 year, given sufficient sample size, high precision of measurements and a treatment effect comparable to that seen in METEOR.Trial Registration: Clinicaltrials.gov identifier: NCT00225589. (Source: Journal of Internal Medicine)

Plasma folate and total homocysteine levels are associated with the risk of myocardial infarction, independently of each other and of renal function

Journal of Internal Medicine — Sat, 28 Feb 2009 05:00:00 +0100

Conclusions. In this large prospective study of a population without mandatory folic acid fortification, both folate and homocysteine were strongly associated with the risk of myocardial infarction, independently of each other and of renal function. Although randomized trials of folic acid supplementation are needed to determine causality, our findings highlight the potential importance of folate, or sources of folate, in incident cardiovascular disease. (Source: Journal of Internal Medicine)

Temporal discrepancies in the association between the apoB/apoA-I ratio and mortality in incident dialysis patients

Journal of Internal Medicine — Fri, 27 Feb 2009 05:00:00 +0100

Conclusions. A high apoB/apoA-I ratio and an increase in this ratio during the first year on dialysis were associated with short-term survival advantage in CKD patients. This paradoxical relationship represents an example of the so-called reverse epidemiology phenomenon in CKD patients and suggests that the apoB/apoA-I ratio should always be interpreted with caution in this patient population. (Source: Journal of Internal Medicine)

Effects of coronary artery disease and percutaneous intervention on the cardiac metabolism of nonesterified fatty acids and insulin: Implications of diabetes mellitus

Journal of Internal Medicine — Tue, 17 Feb 2009 05:00:00 +0100

Conclusion. There is an intracardiac gradient of NEFA and insulin in Groups I[ndash]III. Cardiac NEFA metabolism was higher in those with mild CAD compared with those with obstructive CAD whereas intracardiac insulin extraction was lower in Group III (diabetic) patients. PCI was associated with a systemic rise in NEFA, with a reduction in insulin levels and cardiac utilization, but these effects were blunted in diabetic patients. (Source: Journal of Internal Medicine)

Immune responses against fibronectin modified by lipoprotein oxidation and their association with cardiovascular disease

Journal of Internal Medicine — Mon, 16 Feb 2009 05:00:00 +0100

Conclusions. These observations demonstrate that oxidation of LDL in the arterial wall may lead to aldehyde-modification of surrounding extracellular matrix proteins and that these modifications may affect macrophage function and activate autoimmune responses of pathophysiological importance for the development of atherosclerosis. (Source: Journal of Internal Medicine)

B-type natriuretic peptide and C-terminal-pro-endothelin-1 for the prediction of severely impaired peak oxygen consumption

Journal of Internal Medicine — Mon, 16 Feb 2009 05:00:00 +0100

Conclusions. C-terminal-pro-endothelin-1 is superior to BNP for the prediction of a peak VO2 < 14 mL kg[minus]1 min[minus]1 in patients referred for CPET. A score incorporating body mass index, diabetes status, spirometry, blood gases, BNP and CT-proET-1 improves the prediction of a peak VO2 < 14 mL kg[minus]1 min[minus]1 based on single biomarkers. (Source: Journal of Internal Medicine)

Circulating biomarkers of angiogenesis as indicators of left ventricular systolic dysfunction amongst patients with coronary artery disease

Journal of Internal Medicine — Mon, 02 Feb 2009 05:00:00 +0100

Abstract. Patel JV, Abraheem A, Chackathayil J, Gunning M, Creamer J, Hughes EA, Lip GYH (City Hospital, Birmingham; and University Hospital of North Staffordshire, Stoke-on-Trent, UK). Circulating biomarkers of angiogenesis as indicators of left ventricular systolic dysfunction amongst patients with coronary artery disease. J Intern Med 2009; doi: 10.1111/j.1365-2796.2008.02057.xBackground. Patients with coronary artery disease (CAD) and left ventricular systolic dysfunction (LVSD) are often asymptomatic. Angiogenesis is implicated in the physiology of vascular repair and cardiac remodelling, and is one of many pathophysiological processes implicated in heart failure. We hypothesized that plasma indices associated with angiogenesis [angiogenin, vascular endothelial growth factor (VEGF), a...

Clinical consequences of hospital variation in use of oral anticoagulant therapy after first-time admission for atrial fibrillation

Journal of Internal Medicine — Sat, 10 Jan 2009 05:00:00 +0100

Conclusion. In Denmark between 1995 and 2004, there was a major hospital variation in AF patients receiving OAC, and consequently, more thromboembolic events were observed amongst patients from low OAC use hospitals. Our study emphasizes the need for a continued vigilance on implementation of international AF management guidelines. (Source: Journal of Internal Medicine)

Atrial fibrillation in fracture patients treated with oral bisphosphonates

Journal of Internal Medicine — Wed, 07 Jan 2009 05:00:00 +0100

Conclusions. The increased occurrence of AF in fracture patients who are users of oral bisphosphonates should be attributed to targeting of bisphosphonates to patients who are already at increased risk of cardiovascular events. (Source: Journal of Internal Medicine)

Improved outcome in Wegener's granulomatosis and microscopic polyangiitis? A retrospective analysis of 95 cases in two cohorts

Journal of Internal Medicine — Tue, 23 Dec 2008 05:00:00 +0100

Conclusion. Patient survival in WG and MPA analysed with SMR may be better than previously believed. Severe renal disease and disease relapse were the major predictors of reduced survival. (Source: Journal of Internal Medicine)

Ezetimibe monotherapy for cholesterol lowering in 2,722 people: systematic review and meta-analysis of randomized controlled trials

Journal of Internal Medicine — Tue, 23 Dec 2008 05:00:00 +0100

Conclusions. In a meta-analysis restricted to short-term trials in hypercholesterolaemia, significant potentially favourable changes in lipid and lipoprotein levels relative to baseline occurred with ezetimibe monotherapy. Further long-term studies with cardiovascular and other clinical outcome data are needed to assess the efficacy and safety of ezetimibe more fully. (Source: Journal of Internal Medicine)

Myelodysplastic syndromes: biology and treatment

Journal of Internal Medicine — Fri, 19 Dec 2008 05:00:00 +0100

Abstract. Jädersten M, Hellström-Lindberg E (Karolinska Institutet, Karolinska University Hospital Stockholm, Sweden). Myelodysplastic syndromes: biology and treatment (Review). J Intern Med 2008; doi: 10.1111/j.1365-2796.2008.02052.x Optimal management of patients with myelodysplastic syndromes (MDS) requires an insight into the biology of the disease and the mechanisms of action of the available therapies. This review focuses on low-risk MDS, for which chronic anaemia and eventual progression to acute myeloid leukaemia are the main concerns. We cover the updated World Health Organization classification, the latest prognostic scoring system, and describe novel findings in the pathogenesis of 5q[minus] syndrome. We perform in depth analyses of two of the most widely used treatments, eryt...

Free fatty acid kinetics during long-term treatment with pioglitazone added to sulfonylurea or metformin in Type 2 diabetes

Journal of Internal Medicine — Wed, 26 Nov 2008 05:00:00 +0100

Conclusion. Long-term improvements in adipose tissue insulin sensitivity and reduction in fasting FFAs with pioglitazone may help to reduce lipotoxicity in Type 2 diabetes. (Source: Journal of Internal Medicine)

Errors and omissions in the study of snuff use and hypertension

Journal of Internal Medicine — Thu, 20 Nov 2008 05:00:00 +0100

(Source: Journal of Internal Medicine)

Relationships between lipoprotein components and risk of ischaemic and haemorrhagic stroke in the Apolipoprotein MOrtality RISk study (AMORIS)

Journal of Internal Medicine — Wed, 19 Nov 2008 05:00:00 +0100

Conclusions. Dyslipidaemia is associated with an increased risk of ischaemic stroke but few relations were seen in haemorrhagic stroke. Use of the apoB/apoA-I ratio as a marker of dyslipidaemia is at least as efficient as conventional lipids, for the identification of subjects at increased risk of stroke, especially ischaemic stroke. Practical advantages, fasting is not needed, speak in favour of using apoB and apoA-1 in stroke risk prediction. (Source: Journal of Internal Medicine)

Factors associated with elevated or blunted PTH response in vitamin D insufficient adults

Journal of Internal Medicine — Wed, 19 Nov 2008 05:00:00 +0100

Conclusions. Our results indicate that during vitamin D insufficiency, factors other than calcium and vitamin D may modify PTH response. These factors may be different between sexes and we have identified novel factors, IGF1 and testosterone in men which may be compensatory in nature and confirmed previous factors such as smoking, BMI and kidney function in women. (Source: Journal of Internal Medicine)

Severe parainfluenza virus type 2 supraglottitis in an immunocompetent adult host: an unusual cause of a paramyxoviridae viral infection

Journal of Internal Medicine — Wed, 19 Nov 2008 05:00:00 +0100

We report [ndash] to our knowledge [ndash] the first case of a nonimmunocompromised adult patient with human parainfluenza type 2 supraglottitis immediately after returning from China. (Source: Journal of Internal Medicine)

Heart rate variability, overnight urinary norepinephrine and C-reactive protein: evidence for the cholinergic anti-inflammatory pathway in healthy human adults

Journal of Internal Medicine — Wed, 19 Nov 2008 05:00:00 +0100

Conclusions. We report here for the first time, in a large sample of healthy human adults, evidence supporting the hypothesis of a clinically relevant cholinergic anti-inflammatory pathway after controlling for sympathetic nervous system activity. This suggests an important role for the vagal control of systemic inflammatory activity in cardiovascular disease. (Source: Journal of Internal Medicine)

Prognostic role of the glucometabolic status assessed in a metabolically stable phase after a first acute myocardial infarction: the SHEEP study

Journal of Internal Medicine — Wed, 19 Nov 2008 05:00:00 +0100

Abstract. Janszky I, Hallqvist J, Ljung R, Ahlbom A, Hammar N (Karolinska Institute, Stockholm, Sweden, Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary, Stockholm Centre for Public Health, Stockholm; Karolinska Institute, Stockholm; Karolinska Institute, Stockholm; and AstraZeneca R&D, Mölndal; Sweden). Prognostic role of the glucometabolic status assessed in a metabolically stable phase after a first acute myocardial infarction: the SHEEP study. J Intern Med 2008; doi: 10.1111/j.1365-2796.2008.02036.xObjectives. Our objective was to examine fasting glucose and insulin levels in patients surviving 3 months after a first AMI in relation to long-term prognosis.Design. A total of 1167 consecutive patients between 45 and 70 years with a first nonfatal AMI underwent...

Angiotensin, the hypovolaemia hormone, aggravates hypertension, obesity, diabetes and cancer

Journal of Internal Medicine — Wed, 19 Nov 2008 05:00:00 +0100

(Source: Journal of Internal Medicine)

Exhaled nitric oxide levels in alpha-1-antitrypsin PiMZ subjects

Journal of Internal Medicine — Wed, 29 Oct 2008 04:00:00 +0100

Conclusions. Not only did PiMZ subjects show increased FeNO levels compared with COPD patients and controls; FeNO levels proved to be related to the reduced concentration of plasma AAT. Such findings seem to suggest the importance of FeNO measurements on PiMZ subjects for monitoring a possible progression of airway inflammation to obstructive lung disease as observed in some of these patients. (Source: Journal of Internal Medicine)

Diabetes mellitus impairs CD133+ progenitor cell function after myocardial infarction

Journal of Internal Medicine — Mon, 27 Oct 2008 04:00:00 +0100

Conclusions. Our results show that T2DM not only limits the abundance of CD133+PC following AMI, but also limits their activation. This might be explained by a lower resistance of CD133+PC to oxidative stress. Our data provide a possible explanation for the delayed postischaemic vascular healing and myocardial recovery in DM. (Source: Journal of Internal Medicine)

Severe HDL deficiency due to novel defects in the ABCA1 transporter

Journal of Internal Medicine — Mon, 27 Oct 2008 04:00:00 +0100

Conclusions. The homozygotes for mutations which abolish ABCA1 function showed overt signs of involvement of the reticulo-endothelial system. This was not the case in the compound heterozygote for missense mutations, suggesting that this patient retains some residual ABCA1 function that reduces cholesterol accumulation in the reticulo-endothelial system. (Source: Journal of Internal Medicine)

Association of genetic variation on chromosome 9p21.3 and arterial stiffness

Journal of Internal Medicine — Mon, 27 Oct 2008 04:00:00 +0100

Conclusions. Impaired mechanical properties of the arterial wall may explain the association between chromosome 9p21.3 polymorphisms and vascular disease. (Source: Journal of Internal Medicine)

Elevated cerebrospinal fluid levels of prostaglandin E2 and 15-(S)-hydroxyeicosatetraenoic acid in multiple sclerosis

Journal of Internal Medicine — Mon, 27 Oct 2008 04:00:00 +0100

Conclusion. These data suggest no direct involvement of PGE2 and 15(S)-HETE in the MS disease process. Rather, the elevated levels reflect a general up-regulation of arachidonic acid metabolism and neuroinflammation. (Source: Journal of Internal Medicine)

Common candidate gene variants are associated with QT interval duration in the general population

Journal of Internal Medicine — Mon, 27 Oct 2008 04:00:00 +0100

Conclusions. We demonstrate that each additional copy of the KCNE1 D85N minor allele is associated with a considerable 10.5 ms prolongation of the age-, gender- and heart rate-adjusted QT interval and could thus modulate repolarization-related arrhythmia susceptibility at the population level. In addition, we robustly confirm the previous findings that three independent KCNH2 and NOSA1P variants are associated with adjusted QT interval. (Source: Journal of Internal Medicine)

Predicting ischaemic stroke subtype from presenting systolic blood pressure: the BASIC Project

Journal of Internal Medicine — Mon, 27 Oct 2008 04:00:00 +0100

Conclusions. Lower initial SBP and older age at ischaemic stroke presentation were associated with cardioembolic stroke. Suspicion of cardioembolic stroke should be increased in those presenting with low SBP. (Source: Journal of Internal Medicine)

Migration at early age from a high to a lower coronary heart disease risk country lowers the risk of subclinical atherosclerosis in middle-aged men

Journal of Internal Medicine — Sat, 18 Oct 2008 04:00:00 +0100

Conclusions. Migration at an early age and good integration are beneficial to vascular health associated with moving from a high to a lower CHD risk country, suggesting that an environment-sensitive period influences atherogenesis before adulthood. (Source: Journal of Internal Medicine)

The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study

Journal of Internal Medicine — Thu, 16 Oct 2008 04:00:00 +0100

Conclusions. In the elderly subjects, chronic disability rather than multimorbidity emerged as the strongest negative prognostic factor for functionality and survival. (Source: Journal of Internal Medicine)

Antiflagellin antibodies recognize the autoantigens Toll-Like Receptor 5 and Pals 1-associated tight junction protein and induce monocytes activation and increased intestinal permeability in Crohn's disease

Journal of Internal Medicine — Tue, 16 Sep 2008 04:00:00 +0100

Conclusions. Antibodies directed against an immunodominant peptide of flagellin recognize self-antigens and are functionally active suggesting the presence of an autoimmune process that can both facilitate loss of tolerance to intestinal microflora by increasing cell permeability and amplify the innate immunity involvement through a novel mechanism of TLR5 activation. (Source: Journal of Internal Medicine)

Blood p50 evaluation enhances diagnostic definition of isolated erythrocytosis

Journal of Internal Medicine — Sat, 13 Sep 2008 04:00:00 +0100

Conclusions. This study suggests that the investigation of blood p50 level may be useful to define diagnosis in patients with isolated erythrocytosis. (Source: Journal of Internal Medicine)

Exercise workload, cardiovascular risk factor evaluation and the risk of stroke in middle-aged men

Journal of Internal Medicine — Thu, 11 Sep 2008 04:00:00 +0100

Conclusions. Low exercise workload predicts an especially high risk for stroke in the presence of high risk SCORE. (Source: Journal of Internal Medicine)

Circulating serum adiponectin levels in patients with coronary artery disease: relationship to atherosclerotic burden and cardiac function

Journal of Internal Medicine — Thu, 11 Sep 2008 04:00:00 +0100

Conclusion. Levels of adiponectin decreased with coronary artery disease severity, without impact from systolic dysfunction, but levels may be moderated through established CHD risk factors such as smoking and triglycerides. Further work is warranted as to the clinical prognostic utility of this marker amongst CHD patients. (Source: Journal of Internal Medicine)

Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial

Journal of Internal Medicine — Thu, 11 Sep 2008 04:00:00 +0100

The objective of the present study was to examine the cross-sectional relation between serum 25-hydoxyvitamin D [25-(OH) D] levels and depression in overweight and obese subjects and to assess the effect of vitamin D supplementation on depressive symptoms.Design. Cross-sectional study and randomized double blind controlled trial of 20.000 or 40.000 IU vitamin D per week versus placebo for 1 year.Setting. A total of 441 subjects (body mass index 28[ndash]47 kg m[minus]2, 159 men and 282 women, aged 21[ndash]70 years) recruited by advertisements or from the out-patient clinic at the University Hospital of North Norway.Main outcome measures. Beck Depression Inventory (BDI) score with subscales 1[ndash]13 and 14[ndash]21.Results. Subjects with serum 25(OH)D levels (Source: Journal of Internal ...

Recruitment of Mycobacterium tuberculosis specific CD4+ T cells to the site of infection for diagnosis of active tuberculosis

Journal of Internal Medicine — Thu, 11 Sep 2008 04:00:00 +0100

Conclusions. The accumulation of MTB-specific T cells at the site of infection may prove as useful diagnostic marker for an accurate and rapid diagnosis of active TB. (Source: Journal of Internal Medicine)

Low PAI-1 activity in relation to inflammatory parameters, insulin profile and body mass index

Journal of Internal Medicine — Tue, 09 Sep 2008 04:00:00 +0100

Conclusion. Patients with bleeding tendency and low PAI-1 activity have inflammatory and insulin profiles similar to those with normal or high PAI-1, whereas BMI seems to be the most important determinant. (Source: Journal of Internal Medicine)

Increased levels of nerve growth factor in the airways of patients with sarcoidosis

Journal of Internal Medicine — Mon, 08 Sep 2008 04:00:00 +0100

Conclusions. We demonstrate that secreted levels of NGF are markedly enhanced in the airways in active pulmonary sarcoidosis. Furthermore, a relationship between NGF and pulmonary inflammation in sarcoidosis is supported. (Source: Journal of Internal Medicine)

Treatment with apo B peptide vaccines inhibits atherosclerosis in human apo B-100 transgenic mice without inducing an increase in peptide-specific antibodies

Journal of Internal Medicine — Mon, 08 Sep 2008 04:00:00 +0100

Conclusions. Immunization with apo B peptide-based vaccines inhibits atherosclerosis in mice expressing human apo B-100 suggesting that they can interact with their target as expressed in humans. The protective effect is independent of the pre-existing level of apo B peptide autoantibodies and can occur without activating an increase in peptide-specific antibodies suggesting that atheroprotection can be mediated by cellular immune responses. (Source: Journal of Internal Medicine)

Reduced leucocyte cholesteryl ester transfer protein expression in acute coronary syndromes

Journal of Internal Medicine — Mon, 08 Sep 2008 04:00:00 +0100

Conclusions. We are the first to report that episodes of UAP in humans and myocardial infarction in CETP transgenic mice are associated with reduced leucocyte CETP expression. We propose that the impairment in leucocyte CETP production is associated with an enhanced inflammatory status, which could be clinically relevant for the pathogenesis of ACS. (Source: Journal of Internal Medicine)

The HIV epidemic: squeezing out the African voice

Journal of Internal Medicine — Tue, 02 Sep 2008 04:00:00 +0100

(Source: Journal of Internal Medicine)

Aspirin and clopidogrel with or without phenprocoumon after drug eluting coronary stent placement in patients on chronic oral anticoagulation

Journal of Internal Medicine — Sun, 13 Jul 2008 04:00:00 +0100

Conclusions. In patients on chronic OAC undergoing DES implantation, clinical and echocardiographic criteria help to define postprocedural antithrombotic/anticoagulation therapy. Based on these criteria, both a double antiplatelet therapy (clopidogrel plus aspirin) and a triple therapy (OAC plus clopidogrel plus aspirin) are associated with favourable safety and efficacy. (Source: Journal of Internal Medicine)

Does the varied use of NSAIDs explain the differences in the risk of myocardial infarction?

Journal of Internal Medicine — Wed, 09 Jul 2008 04:00:00 +0100

Abstract. van Staa T-P, Rietbrock S, Setakis E, Leufkens HGM (Medicines and Healthcare Products Regulatory Agency, London, UK; Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands). Does the varied use of NSAIDs explain the differences in the risk of myocardial infarction? J Intern Med 2008;Objective. To investigate the risk of myocardial infarction (MI) with diclofenac, ibuprofen and naproxen, taking into account the exposure patterns.Design. Retrospective cohort study using the General Practice Research Database.Setting. UK primary care.Subjects. Patients aged 40+ years prescribed a traditional nonsteroidal anti-inflammatory drug (NSAID). The control cohort was frequency matched by disease risk score.Intervention. Observational comparisons of MI rat...

Thionamide-induced vasculitis: a case of alveolar haemorrhage secondary to propylthiouracil

Journal of Internal Medicine — Wed, 09 Jul 2008 04:00:00 +0100

(Source: Journal of Internal Medicine)

The combined effect of albuminuria and inflammation on all-cause and cardiovascular mortality in nondiabetic persons

Journal of Internal Medicine — Tue, 08 Jul 2008 04:00:00 +0100

Conclusion. ACR predicts all-cause and cardiovascular mortality in persons without known diabetes and macroalbuminuria. The mortality is especially high amongst individuals with elevated levels of both ACR and inflammatory markers. (Source: Journal of Internal Medicine)

Corrigenda

Journal of Internal Medicine — Tue, 10 Jun 2008 22:07:13 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: Journal of Internal Medicine)

Revisiting human primary immunodeficiencies

Journal of Internal Medicine — Mon, 09 Jun 2008 18:28:56 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Casanova J-L, Fieschi C, Zhang S-Y, Abel L (Institut National de la Santé et de la Recherche Médicale; University Paris Descartes, Necker Medical School; Necker Children’s Hospital; Saint Louis Hospital; Paris, France, EU; and Shanghai Ruijin Hospital, ... (Source: Journal of Internal Medicine)

Apolipoproteins: promising biomarkers for cardiovascular risk prediction

Journal of Internal Medicine — Mon, 09 Jun 2008 08:33:27 +0100

Journal of Internal Medicine, Volume 264, Issue 1, Page 1-3, July 2008. (Source: Journal of Internal Medicine)

Chronic obstructive pulmonary disease in patients admitted with heart failure

Journal of Internal Medicine — Thu, 05 Jun 2008 18:30:39 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Iversen KK, Kjaergaard J, Akkan D, Kober L, Torp-Pedersen C, Hassager C, Vestbo J, Kjoller E (Rigshospitalet and Bispebjerg Hospital, Copenhagen, Hvidovre Hospital, Hvidovre, Denmark, Wythenshawe Hospital, Manchester, UK, and Herlev Hospital, Herlev, ... (Source: Journal of Internal Medicine)

Determinants of plasma apolipoprotein A-V and APOA5 gene transcripts in humans

Journal of Internal Medicine — Thu, 05 Jun 2008 08:43:06 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Hahne P, Krempler F, Schaap FG, Soyal SM, Höffinger H, Miller K, Oberkofler H, Strobl W, Patsch W (Paracelsus Medical University, Salzburg; Krankenhaus Hallein, Hallein, Austria; AMC Liver Centre, Amsterdam, The Netherlands; and Medical University of ... (Source: Journal of Internal Medicine)

Cardiovascular events and all-cause mortality by albuminuria and decreased glomerular filtration rate in patients with vascular disease

Journal of Internal Medicine — Tue, 03 Jun 2008 18:31:39 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Vlek ALM, van der Graaf Y, Spiering W, Algra A, Visseren FLJ (UMC Utrecht, Utrecht, The Netherlands). Cardiovascular events and all-cause mortality by albuminuria and decreased glomerular filtration rate in patients with vascular disease. J Intern Med ... (Source: Journal of Internal Medicine)

Central nervous system involvement in severe congenital neutropenia: neurological and neuropsychological abnormalities associated with specific HAX1 mutations

Journal of Internal Medicine — Thu, 29 May 2008 18:33:48 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Carlsson G, van’t Hooft I, Melin M, Entesarian M, Laurencikas E, Nennesmo I, Trębińska A, Grzybowska E, Palmblad J, Dahl N, Nordenskjöld M, Fadeel B, Henter J-I (Karolinska Institutet, Stockholm, Sweden; Uppsala University, Uppsala, Sweden; Cancer Center ... (Source: Journal of Internal Medicine)

Biological functions and clinical implications of oestrogen receptors alfa and beta in epithelial tissues

Journal of Internal Medicine — Thu, 29 May 2008 13:39:20 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Morani A, Warner M, Gustafsson J-Å (Karolinska Institutet, Novum, Huddinge, Sweden). Biological functions and clinical implications of oestrogen receptors alfa and beta in epithelial tissues (Review). J Intern Med 2008;For the past 10 years it is known ... (Source: Journal of Internal Medicine)

A common haplotype of the C-C chemokine receptor 2 gene and HLA-DRB1*0301 are independent genetic risk factors for Löfgren’s syndrome

Journal of Internal Medicine — Thu, 29 May 2008 13:39:13 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Spagnolo P, Sato H, Grunewald J, Brynedal B, Hillert J, Mañá J, Wells AU, Eklund A, Welsh KI, du Bois RM (Clinical Genomic Group, National Heart and Lung Institute, Imperial College, London, UK; Karolinska Institutet and Karolinska University Hospital ... (Source: Journal of Internal Medicine)

Combined effects of obesity and physical activity in predicting mortality among men

Journal of Internal Medicine — Thu, 29 May 2008 13:39:04 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Orsini N, Bellocco R, Bottai M, Pagano M, Michaelsson K, Wolk A. (Karolinska Institutet, Stockholm, Sweden; University of South Carolina, Columbia, SC, USA; Harvard University, Boston, MA, USA; University of Milano-Bicocca, Milano, Italy; and University ... (Source: Journal of Internal Medicine)

Endoscopy in Barrett’s oesophagus: adherence to standards and neoplasia detection in the community practice versus hospital setting

Journal of Internal Medicine — Thu, 15 May 2008 18:30:47 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Pohl H, Aschenbeck J, Drossel R, Schröder A, Mayr M, Koch M, Rothe K, Anders M, Voderholzer W, Hoffmann J, Schulz H-J, Liehr R-M, Gottschalk U, Wiedenmann, B, Rösch T (Charité University Hospitals, Humboldt Hospital, and Maria Heimsuchung Hospital, Berlin,... (Source: Journal of Internal Medicine)

Circulating matrix metalloproteinase-9 levels in atherosclerotic vascular disease: a possible measurement of systemic or specific disease pathophysiology?

Journal of Internal Medicine — Mon, 12 May 2008 16:05:41 +0100

Journal of Internal Medicine, Volume 263, Issue 6, Page 620-622, June 2008. (Source: Journal of Internal Medicine)

Inflammatory bowel disease think tank

Journal of Internal Medicine — Mon, 12 May 2008 16:05:40 +0100

Journal of Internal Medicine, Volume 263, Issue 6, Page 573, June 2008. (Source: Journal of Internal Medicine)

A gut feeling of the PXR, PPAR and NF-κB connection

Journal of Internal Medicine — Mon, 12 May 2008 16:03:54 +0100

Journal of Internal Medicine, Volume 263, Issue 6, Page 613-619, June 2008. Wahli W (Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland). A gut feeling of the PXR, PPAR and NF-κB connection (Review). J Intern Med 2008; 263: 613–619.Bowel diseases reveal ... (Source: Journal of Internal Medicine)

Neuro-glial crosstalk in inflammatory bowel disease

Journal of Internal Medicine — Mon, 12 May 2008 16:02:35 +0100

Journal of Internal Medicine, Volume 263, Issue 6, Page 577-583, June 2008. Neunlist M, Van Landeghem L, Bourreille A, Savidge T (INSERM, U913, Université de Nantes, Institut des Maladies de l’Appareil Digestif, Nantes, France; and University of Texas Medical Branch, Galveston, TX, USA). Neuro-glial crosstalk in inflammatory ... (Source: Journal of Internal Medicine)

The Interleukin-23 / Interleukin-17 axis in intestinal inflammation

Journal of Internal Medicine — Mon, 12 May 2008 16:01:40 +0100

Journal of Internal Medicine, Volume 263, Issue 6, Page 584-590, June 2008. Maloy KJ (Sir William Dunn School of Pathology, University of Oxford, UK). The Interleukin-23/Interleukin-17 axis in intestinal inflammation (Review). J Intern Med 2008; 263: 584–590.Although the precise aetiology of inflammatory bowel disease (IBD) ... (Source: Journal of Internal Medicine)

Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases

Journal of Internal Medicine — Mon, 12 May 2008 16:01:24 +0100

Journal of Internal Medicine, Volume 263, Issue 6, Page 597-606, June 2008. Packey CD, Sartor RB (University of North Carolina at Chapel Hill, Chapel Hill, NC, USA). Interplay of commensal and pathogenic bacteria, genetic mutations and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases (Review). J Intern ... (Source: Journal of Internal Medicine)

Introduction: Inflammatory bowel disease: a complex systemic disease engaging multiple players outside the immune system

Journal of Internal Medicine — Mon, 12 May 2008 16:01:22 +0100

Journal of Internal Medicine, Volume 263, Issue 6, Page 574-576, June 2008. (Source: Journal of Internal Medicine)

NF-κB in inflammatory bowel disease

Journal of Internal Medicine — Mon, 12 May 2008 16:01:00 +0100

Journal of Internal Medicine, Volume 263, Issue 6, Page 591-596, June 2008. Atreya I, Atreya R, Neurath MF (Institute of Molecular Medicine and I. Medical Clinic, University of Mainz, Germany). NF-κB in inflammatory bowel disease (Review). J Intern Med 2008; 263: 591–596.Apart from genetic and environmental factors, the mucosal ... (Source: Journal of Internal Medicine)

Controlling the cardiovascular disease epidemic

Journal of Internal Medicine — Mon, 12 May 2008 16:00:59 +0100

Journal of Internal Medicine, Volume 263, Issue 6, Page 623-625, June 2008. (Source: Journal of Internal Medicine)

Gastrointestinal inflammation: lessons from metabolic modulators

Journal of Internal Medicine — Mon, 12 May 2008 16:00:58 +0100

Journal of Internal Medicine, Volume 263, Issue 6, Page 607-612, June 2008. Arulampalam V (Karolinska Institutet, Stockholm, Sweden). Gastrointestinal inflammation:lessons from metabolic modulators (Review). J Intern Med 2008; 263: 607–612.The link between inflammation and metabolism was apparent already early last century, but ... (Source: Journal of Internal Medicine)

Familial (shared environmental and genetic) factors and the foetal origins of cardiovascular diseases and type 2 diabetes: a review of the literature

Journal of Internal Medicine — Wed, 30 Apr 2008 18:52:45 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Bergvall N, Cnattingius S (Karolinska Institutet, Stockholm, Sweden). Familial (shared environmental and genetic) factors and the foetal origins of cardiovascular diseases and type 2 diabetes: a review of the literature (Review). J Intern Med 2008; doi: ... (Source: Journal of Internal Medicine)

High D-dimer levels increase the likelihood of pulmonary embolism

Journal of Internal Medicine — Tue, 29 Apr 2008 19:36:08 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Tick LW, Nijkeuter M, Kramer MHH, Hovens MMC, Büller HR, Leebeek FWG, Huisman MV (Meander Medical Center, Amersfoort, Leiden University Medical Center, Leiden, Academic Medical Center, Amsterdam, and Erasmus University Medical Center, Rotterdam, The ... (Source: Journal of Internal Medicine)

Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease

Journal of Internal Medicine — Thu, 10 Apr 2008 09:40:19 +0100

Journal of Internal Medicine, Volume 263, Issue 5, Page 500-505, May 2008. Wang M, Song W-L, Cheng Y, FitzGerald GA (University of Pennsylvania, Philadelphia, PA, USA). Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease (Review). J Intern Med 2008; 263: 500–505.Prostaglandins (PGs), ... (Source: Journal of Internal Medicine)

Proteolysis of low density lipoprotein particles by Porphyromonas gingivalis microorganisms: a novel biochemical link between periodontitis and cardiovascular diseases?

Journal of Internal Medicine — Thu, 10 Apr 2008 09:40:14 +0100

Journal of Internal Medicine, Volume 263, Issue 5, Page 553-557, May 2008. (Source: Journal of Internal Medicine)

Atherosclerosis as inflammation – a controversial concept becomes accepted

Journal of Internal Medicine — Thu, 10 Apr 2008 09:40:13 +0100

Journal of Internal Medicine, Volume 263, Issue 5, Page 461, May 2008. (Source: Journal of Internal Medicine)

The molecular mechanisms of the thrombotic complications of atherosclerosis

Journal of Internal Medicine — Thu, 10 Apr 2008 09:39:54 +0100

Journal of Internal Medicine, Volume 263, Issue 5, Page 517-527, May 2008. Abstract. Libby P (Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA). The molecular mechanisms of the thrombotic complications of atherosclerosis (Review). J Intern Med 2008; 263: 517–527Our evolving knowledge of the cellular and ... (Source: Journal of Internal Medicine)

Identifying the susceptibility genes for coronary artery disease: from hyperbole through doubt to cautious optimism

Journal of Internal Medicine — Thu, 10 Apr 2008 09:38:47 +0100

Journal of Internal Medicine, Volume 263, Issue 5, Page 538-552, May 2008. Hamsten A, Eriksson P (Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden). Identifying the susceptibility genes for coronary artery disease: from hyperbole through doubt to cautious optimism (Review). J Intern Med 2008; 263: 538–... (Source: Journal of Internal Medicine)

Autoimmunity in atherosclerosis: a protective response losing control?

Journal of Internal Medicine — Thu, 10 Apr 2008 09:38:40 +0100

Journal of Internal Medicine, Volume 263, Issue 5, Page 464-478, May 2008. Nilsson J, Hansson GK (Lund University, Malmö; and Karolinska Institute, Stockholm; Sweden). Autoimmunity in atherosclerosis: a protective response losing control? (Review). J Intern Med 2008; 263: 464–478.Atherosclerosis is a chronic inflammatory disease ... (Source: Journal of Internal Medicine)

Oxidation-specific epitopes are important targets of innate immunity

Journal of Internal Medicine — Thu, 10 Apr 2008 09:38:39 +0100

Journal of Internal Medicine, Volume 263, Issue 5, Page 479-488, May 2008. Chou M-Y, Hartvigsen K, Hansen LF, Fogelstrand L, Shaw PX, Boullier A, Binder CJ, Witztum JL (University of California at San Diego, San Diego, CA, USA; INSERM, ERI12 and Laboratoire de Biochimie, Amiens, France; and Medical University of Vienna, Vienna, ... (Source: Journal of Internal Medicine)

Regulatory T-cell immunity and its relevance to atherosclerosis

Journal of Internal Medicine — Thu, 10 Apr 2008 09:38:37 +0100

Journal of Internal Medicine, Volume 263, Issue 5, Page 489-499, May 2008. Taleb S, Tedgui A, Mallat Z (Centre de Recherche Cardiovasculaire Lariboisière, Inserm U689, Paris, France). Regulatory T-cell immunity and its relevance to atherosclerosis (Review). J Intern Med 2008; 263: 489–499.Atherosclerosis is a chronic ... (Source: Journal of Internal Medicine)

From vulnerable plaque to atherothrombosis

Journal of Internal Medicine — Thu, 10 Apr 2008 09:38:36 +0100

Journal of Internal Medicine, Volume 263, Issue 5, Page 506-516, May 2008. Thim T, Hagensen MK, Bentzon JF, Falk E (Aarhus University Hospital, Skejby; and University of Aarhus, Aarhus; Denmark). From vulnerable plaque to atherothrombosis (Review). J Intern Med 2008; 263: 506–516.Plaque rupture precipitates approximately 75% of ... (Source: Journal of Internal Medicine)

Introduction: Atherosclerosis as inflammation: a controversial concept becomes accepted

Journal of Internal Medicine — Thu, 10 Apr 2008 09:38:35 +0100

Journal of Internal Medicine, Volume 263, Issue 5, Page 462-463, May 2008. (Source: Journal of Internal Medicine)

Role of microparticles in atherothrombosis

Journal of Internal Medicine — Thu, 10 Apr 2008 09:38:24 +0100

Journal of Internal Medicine, Volume 263, Issue 5, Page 528-537, May 2008. Leroyer AS, Tedgui A, Boulanger CM (Institut National de la Santé et de la Recherche Médicale, Cardiovascular Research Institute Inserm, France). Role of microparticles in atherothrombosis (Review). J Intern Med 2008; 263: 528–537.Cell activation or ... (Source: Journal of Internal Medicine)

Predictable and unpredictable evolution of antibiotic resistance

Journal of Internal Medicine — Mon, 07 Apr 2008 18:32:04 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Courvalin P (Institut Pasteur, Paris, France). Predictable and unpredictable evolution of antibiotic resistance (Review). J Intern Med 2008;Evolution of bacteria towards antibiotic resistance is unavoidable as it represents a particular aspect of the ... (Source: Journal of Internal Medicine)

20-year trends in clinical characteristics, therapy and short-term prognosis in acute myocardial infarction according to presenting electrocardiogram: the MONICA / KORA AMI Registry (1985–2004)

Journal of Internal Medicine — Fri, 04 Apr 2008 18:30:35 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Kuch B, Heier M, von Scheidt W, Kling B, Hoermann A, Meisinger C (Hospital of Augsburg, Augsburg; Helmholtz Research Center for Environmental Health, Neuherberg). 20-year trends in clinical characteristics, therapy and short-term prognosis in acute ... (Source: Journal of Internal Medicine)

Cardiac involvement in adults with Pompe disease

Journal of Internal Medicine — Fri, 04 Apr 2008 11:12:56 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Soliman OII, van der Beek NAME, van Doorn PA, Vletter WB, Nemes A, Van Dalen BM, ten Cate FJ, van der Ploeg AT, Geleijnse ML (Erasmus University Medical Center, Rotterdam, The Netherlands). Cardiac involvement in adults with Pompe disease. J Intern Med ... (Source: Journal of Internal Medicine)

Psychosocial profile in men and women with unexplained chest pain

Journal of Internal Medicine — Fri, 04 Apr 2008 11:12:46 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Jerlock M, Kjellgren KI, Gaston-Johansson F, Lissner L, Manhem K, Rosengren A, Welin C (Institute of Health and Care Sciences; Johns Hopkins University; the Sahlgrenska Academy; Sahlgrenska University Hospital/Östra, Gothenburg; Sweden). Psychosocial ... (Source: Journal of Internal Medicine)

Physician gender is associated with the quality of type 2 diabetes care

Journal of Internal Medicine — Fri, 04 Apr 2008 11:12:39 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Berthold HK, Gouni-Berthold I, Bestehorn KP, Böhm M, Krone W (University of Bonn, Bonn; University of Cologne, Cologne; MSD Sharp & Dohme GmbH, Haar; and University of Homburg, Homburg/Saar; Germany). Physician gender is associated with the quality of ... (Source: Journal of Internal Medicine)

Virulence blockers as alternatives to antibiotics: type III secretion inhibitors against Gram-negative bacteria

Journal of Internal Medicine — Thu, 03 Apr 2008 19:14:33 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Keyser P, Elofsson M, Rosell S, Wolf-Watz H (Innate Pharmaceuticals AB and Umeå University; Umeå, Sweden). Virulence blockers as alternatives to antibiotics: type III secretion inhibitors against Gram-negative bacteria (Review). J Intern Med 2008; doi: ... (Source: Journal of Internal Medicine)

Risk of hypertension amongst Swedish male snuff users: a prospective study

Journal of Internal Medicine — Thu, 03 Apr 2008 18:07:04 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Hergens M-P, Lambe M, Pershagen G, Ye W (Karolinska Institutet and Stockholm County Council; Stockholm, Sweden). Risk of hypertension amongst Swedish male snuff users: a prospective study. J Intern Med 2008; Background. The scientific evidence on whether ... (Source: Journal of Internal Medicine)

Circulating matrix metalloproteinase 9 levels in relation to sampling methods, femoral and carotid atherosclerosis

Journal of Internal Medicine — Thu, 13 Mar 2008 18:49:10 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Olson FJ, Schmidt C, Gummesson A, Sigurdardottir V, Hulthe J, Wiklund O, Fagerberg B (Sahlgrenska Academy at Göteborg University, Göteborg; and Astra Zeneca R&D, Mölndal, Sweden). Circulating matrix metalloproteinase 9 levels in relation to sampling ... (Source: Journal of Internal Medicine)

l-Arginine preferentially dilates stenotic segments of coronary arteries thereby increasing coronary flow

Journal of Internal Medicine — Thu, 13 Mar 2008 10:30:56 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Lauer T, Kleinbongard P, Rath J, Schulz R, Kelm M, Rassaf T (University Hospital RWTH Aachen, Aachen; Department of Cardiology and Internal Medicine, Städtische Kliniken Solingen; and University of Essen, Essen; Germany). l-Arginine preferentially dilates ... (Source: Journal of Internal Medicine)

A strong note of caution in using matrix metalloproteinase-1 and its inhibitor, TIMP-1 in serum as biomarkers in systolic heart failure

Journal of Internal Medicine — Thu, 13 Mar 2008 10:30:55 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: Journal of Internal Medicine)

Plasma exchange for the management of the catastrophic antiphospholipid syndrome: importance of the type of fluid replacement

Journal of Internal Medicine — Thu, 13 Mar 2008 10:30:54 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. (Source: Journal of Internal Medicine)

Endogenous sex hormones and C-reactive protein in healthy postmenopausal women

Journal of Internal Medicine — Thu, 13 Mar 2008 10:30:53 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Störk S, Bots ML, Grobbee DE, van der Schouw YT (University of Würzburg, Würzburg, Germany, and University Medical Center Utrecht, Utrecht, The Netherlands). Endogenous sex hormones and C-reactive protein in healthy postmenopausal women. J Intern Med 2008;... (Source: Journal of Internal Medicine)

Essential role of choline for pneumococcal virulence in an experimental model of meningitis

Journal of Internal Medicine — Thu, 06 Mar 2008 19:41:27 +0100

Journal of Internal Medicine, Volume 0, Issue 0, Page ???, OnlineEarly Articles. Gehre F, Leib SL, Grandgirard D, Kummer J, Bühlmann A, Simon F, Gäumann R, Kharat AS, Täuber MG, Tomasz A (The Rockefeller University, New York, USA; and Institute for Infectious Diseases, University of Bern, Bern, Switzerland). Essential role of choline ... (Source: Journal of Internal Medicine)

Hypertriglyceridaemia and low plasma HDL in a patient with apolipoprotein A-V deficiency due to a novel mutation in the APOA5 gene

Journal of Internal Medicine — Thu, 06 Mar 2008 12:16:06 +0100

Journal of Internal Medicine, Volume 263, Issue 4, Page 450-458, April 2008. Priore Oliva C, Carubbi F, Schaap FG, Bertolini S, Calandra S (University of Modena & Reggio Emilia, Modena, Italy; AMC Liver Center, Amsterdam, The Netherlands; University of Genova, Genova, Italy). Hypertriglyceridaemia and low plasma HDL in a patient ... (Source: Journal of Internal Medicine)

Renin–angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective cohort study

Journal of Internal Medicine — Thu, 06 Mar 2008 12:15:54 +0100

Journal of Internal Medicine, Volume 263, Issue 4, Page 376-385, April 2008. Conen D, Glynn RJ, Buring JE, Ridker PM, Zee RY (Harvard Medical School, Boston, MA, USA). Renin–angiotensin and endothelial nitric oxide synthase gene polymorphisms are not associated with the risk of incident type 2 diabetes mellitus: a prospective ... (Source: Journal of Internal Medicine)

Erratum: Erratum

Journal of Internal Medicine — Thu, 06 Mar 2008 12:15:41 +0100

Journal of Internal Medicine, Volume 263, Issue 4, Page 459, April 2008. (Source: Journal of Internal Medicine)