MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Internal Medicine' source. Thu, 09 Feb 2012 09:15:11 +0100 http://www.medworm.com/index.php?rid=5672294&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02502.x AbstractPathogenic mutations in the tumour suppressor genes BRCA1 and BRCA2 confer increased risks for breast and ovarian cancer and account for approximately 15% of the excess familial risk of breast cancer among first degree relatives of breast cancer patients. There is considerable evidence indicating that these risks vary by other genetic and environmental factors clustering in families. In the past few years, based on the availability of genome‐wide association data and samples form large collaborative studies, several common alleles have been found to modify breast or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. These common alleles explain a small proportion of the genetic variability in breast or ovarian cancer risk for mutation carriers, suggesting more modifiers r... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5672294 Mon, 06 Feb 2012 05:00:00 +0100 5672294 http://www.medworm.com/index.php?rid=5672293&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02508.x AbstractThe individual human genome and epigenome are being defined at unprecedented resolution by current advances in sequencing technologies with important implications for human disease. This review uses examples relevant to clinical practice to illustrate the functional consequences of genetic and epigenetic variation. The insights gained from genome‐wide association studies are described together with current efforts to understand the role of rare variants in common disease, set in the context of recent successes in Mendelian traits through application of whole exome sequencing. The application of functional genomics to interrogate the genome and epigenome, build up an integrated picture of the regulatory genomic landscape and inform disease association studies is discussed, togethe... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5672293 Mon, 06 Feb 2012 05:00:00 +0100 5672293 http://www.medworm.com/index.php?rid=5672292&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02509.x AbstractIn this article, we review the current knowledge of the inherited genetics of epithelial ovarian cancer (EOC) susceptibility and clinical outcome. We focus on recent developments in identifying low‐penetrance susceptibility genes and the role of the ovarian cancer association consortium (OCAC) in these discoveries. The ovarian cancer association consortium (OCAC) was established to facilitate large‐scale replication analyses for reported genetic associations for EOC. Since its inception, the OCAC has conducted both candidate gene and genome wide association studies (GWAS); the latter has identified six established loci for EOC susceptibility most of which showed stronger association with the serous histological subtype. Future GWAS and sequencing studies are likely to result in... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5672292 Mon, 06 Feb 2012 05:00:00 +0100 5672292 http://www.medworm.com/index.php?rid=5672291&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02511.x AbstractProstate cancer is the commonest cancer in the developed world. There is an inherited component to this disease as shown in familial and twin studies. However, the discovery of these variants has been difficult. The emergence of genome‐wide association studies (GWAS) has led to the identification of over 46 susceptibility loci. Their clinical utility to predict risk, response to treatment, or treatment toxicity, remains undefined. Large consortia are needed to achieve adequate statistical power to answer these genetic‐clinical and genetic‐epidemiological questions. International collaborations are currently underway to link genetic with clinical/epidemiological data to develop risk prediction models, which could direct screening and treatment programs. (Source: Journal of Int... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5672291 Mon, 06 Feb 2012 05:00:00 +0100 5672291 http://www.medworm.com/index.php?rid=5672290&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02527.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5672290 Wed, 01 Feb 2012 05:00:00 +0100 5672290 http://www.medworm.com/index.php?rid=5663229&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02526.x Conclusion:  The results suggest that the relationships with inflammation for ischaemic stroke and ICH are different. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5663229 Wed, 01 Feb 2012 05:00:00 +0100 5663229 http://www.medworm.com/index.php?rid=5654492&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02525.x AbstractBreast cancer is not only increasing in the West but also particularly rapidly in Eastern countries where traditionally the incidence has been low. The rise in incidence is mainly related to changes in reproductive patterns and lifestyle. These trends could potentially be reversed by defining women at greatest risk and offering appropriate preventive measures. A model for this approach was the establishment of Family History Clinics (FHCs) which have resulted in improved survival in younger women at high risk. New predictive models of risk which include reproductive and life style factors, mammographic density and measurement of risk associated single nucleotide polymorphisms (SNPs) may give more precise information concerning risk and enable better targeting for mammographic scree... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5654492 Wed, 01 Feb 2012 05:00:00 +0100 5654492 http://www.medworm.com/index.php?rid=5654494&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02523.x Conclusions:  Changes in hsCRP were consistent with the inhibitory effect of increased vagal efferent activity on pro‐inflammatory factors predicted by the cholinergic anti‐inflammatory reflex model. Clinical trials for patients with cardiovascular dysfunction are warranted to assess whether behavioural interventions can contribute independently to the chronic regulation of inflammatory activity and to improved clinical outcomes. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5654494 Tue, 31 Jan 2012 05:00:00 +0100 5654494 http://www.medworm.com/index.php?rid=5654493&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02524.x Conclusion:  The type of immunohistochemical DES expression correlated with the level of myocardial injury at the cellular and organ levels. This correlation was similar to that observed between DES expression and the well‐established biochemical, echocardiographic and clinical parameters of heart failure (HF). DES expression type could be used as an important diagnostic feature of HF development. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5654493 Tue, 31 Jan 2012 05:00:00 +0100 5654493 http://www.medworm.com/index.php?rid=5633653&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02522.x AbstractGenomewide Association Studies (GWAS) have identified thousands of consistently replicated associations between genetic markers and complex disease risk, including cancers. Alone, these markers have limited utility in risk prediction; however, when several of these markers are used in combination, the predictive performance appears to be similar to currently many available clinical predictors. Despite this, there are divergent views regarding the clinical validity and utility of these genetic markers in risk prediction. There are valid concerns, thus providing a direction for new lines of research. Herein, we outline the debate, and use the example of prostate cancer to highlight emerging evidence from studies that aim to address potential concerns. We also describe a translational... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5633653 Fri, 27 Jan 2012 14:04:13 +0100 5633653 http://www.medworm.com/index.php?rid=5615366&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02521.x Conclusions:  Poorer self‐rated physical and mental health status increases the risk of vascular events and mortality in a broad population of patients with symptomatic and asymptomatic atherosclerotic disease. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5615366 Sat, 21 Jan 2012 13:43:36 +0100 5615366 http://www.medworm.com/index.php?rid=5602487&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02498.x Abstract.  Tian Q, Price ND, Hood L (Institute for Systems Biology, Seattle, WA, USA). Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine (Key Symposium). J Intern Med 2012; 271: 111–121.A grand challenge impeding optimal treatment outcomes for patients with cancer arises from the complex nature of the disease: the cellular heterogeneity, the myriad of dysfunctional molecular and genetic networks as results of genetic (somatic) and environmental perturbations. Systems biology, with its holistic approach to understanding fundamental principles in biology, and the empowering technologies in genomics, proteomics, single‐cell analysis, microfluidics and computational strategies, enables a comprehensive approach to medicine... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5602487 Wed, 18 Jan 2012 14:48:06 +0100 5602487 http://www.medworm.com/index.php?rid=5602486&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02506.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5602486 Wed, 18 Jan 2012 14:48:02 +0100 5602486 http://www.medworm.com/index.php?rid=5602485&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02519.x Conclusion:  Within this large Caucasian population, we identified the highest community‐based prevalence of AF to date. The prevalence was strongly associated with increasing age and male gender. Using CHA2DS2‐VASc instead of CHADS2 widened the indication for OAC prophylactic therapy of AF in this population. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5602485 Wed, 18 Jan 2012 14:46:50 +0100 5602485 http://www.medworm.com/index.php?rid=5590697&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02518.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5590697 Fri, 13 Jan 2012 05:00:00 +0100 5590697 http://www.medworm.com/index.php?rid=5590698&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02516.x Conclusion:  The prevalence of mutations in LPL was 34% and mostly restricted to patients with type 1 HTG. Mutations in GPIHBP1 (n=3), APOC2 (n=1) and APOA5 (n=2) were rare but the associated clinical phenotype was severe. Routine sequencing of candidate genes in severe HTG has improved our understanding of the molecular basis of this phenotype associated with acute pancreatitis, and may help to guide future individualized therapeutic strategies. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5590698 Thu, 12 Jan 2012 05:00:00 +0100 5590698 http://www.medworm.com/index.php?rid=5590696&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2012.02517.x Conclusions:  IL‐1β levels after STEMI were strongly associated with impaired myocardial function and non‐infarct LV mass after 1 year, suggesting a potential role for IL‐1β as a predictor of maladaptive myocardial remodelling following reperfused MI. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5590696 Sun, 01 Jan 2012 05:00:00 +0100 5590696 http://www.medworm.com/index.php?rid=5555978&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02515.x AbstractThe pathogenetic mechanisms that cause the two types of inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC), are still under investigation. Nevertheless, there is broad agreement that luminal microbes are of particular relevance in the development of these conditions. In recent years, increasing evidence has shown that defects in the innate immunity are at the centre of both types of IBD. The innate intestinal barrier is provided by the epithelium which secretes antimicrobial peptides (so‐called defensins) that are retained in the mucus layer. In ileal CD, the alpha‐defensins are lacking due to several Paneth cell defects. In colonic CD, the expression of beta‐defensins is inadequate. This may be related to downregulation of the transcription ... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5555978 Sun, 01 Jan 2012 05:00:00 +0100 5555978 http://www.medworm.com/index.php?rid=5555983&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02499.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5555983 Fri, 30 Dec 2011 05:00:00 +0100 5555983 http://www.medworm.com/index.php?rid=5555982&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02510.x Conclusions:  PMR is associated with a significant imbalance between endothelial injury and repair, which is dependent on the degree of systemic inflammation. Attenuation of inflammation by short‐term corticosteroid therapy might have a role in limiting endothelial fragmentation and promote endothelial repair. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5555982 Fri, 30 Dec 2011 05:00:00 +0100 5555982 http://www.medworm.com/index.php?rid=5555981&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02512.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5555981 Fri, 30 Dec 2011 05:00:00 +0100 5555981 http://www.medworm.com/index.php?rid=5555980&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02513.x AbstractHaemoglobin A1c (HbA1c) has recently been adopted by the World Health Organisation into its recommended criteria for diabetes diagnosis. Much debate continues regarding the relative benefits and potential disadvantages surrounding the use of HbA1c for this purpose. There is a lack of consensus as to whether this alteration to the definition of diabetes is a step forward or whether it could add further confusion and ambiguity to the debate on the method and criteria for the diagnosis of this globally important disease. This review provides a comprehensive overview of the current issues surrounding how HbA1c is measured and reported; and of the evidence for and against its use in diagnosis. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5555980 Fri, 30 Dec 2011 05:00:00 +0100 5555980 http://www.medworm.com/index.php?rid=5555979&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02514.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5555979 Fri, 30 Dec 2011 05:00:00 +0100 5555979 http://www.medworm.com/index.php?rid=5548632&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02504.x Conclusions:  In REDUCE, PCa family history was significantly related with PCa diagnosis, though only for men outside North America. The presence of both PCa and BCa family history significantly increased risk versus PCa family history alone, irrespective of geographical region. Ultimately, our observations may support the need for changes in how we address family history in terms of both risk of PCa diagnosis and general risk stratification. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5548632 Thu, 29 Dec 2011 06:28:06 +0100 5548632 http://www.medworm.com/index.php?rid=5548635&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02500.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5548635 Wed, 28 Dec 2011 05:00:00 +0100 5548635 http://www.medworm.com/index.php?rid=5548634&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02501.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5548634 Wed, 28 Dec 2011 05:00:00 +0100 5548634 http://www.medworm.com/index.php?rid=5548633&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02503.x Conclusion:  NGAL added no significant information to NT‐proBNP and GFR in a multivariate model for primary and secondary endpoints. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5548633 Wed, 28 Dec 2011 05:00:00 +0100 5548633 http://www.medworm.com/index.php?rid=5510516&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02468.x This article comments on: Myalgic encephalomyelitis: International Consensus Criteria (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5510516 Sat, 17 Dec 2011 02:13:20 +0100 5510516 http://www.medworm.com/index.php?rid=5510512&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02505.x Conclusion:  Older age, high BMI and low levels of HDL‐C are related to echolucency of the carotid intima–media. Hence, echolucency of the carotid intima–media may be used as a marker of cardiovascular risk profile to provide more information than thickness alone. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5510512 Sat, 17 Dec 2011 02:12:02 +0100 5510512 http://www.medworm.com/index.php?rid=5481591&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02490.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5481591 Mon, 05 Dec 2011 05:00:00 +0100 5481591 http://www.medworm.com/index.php?rid=5481590&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02492.x AbstractComplex intracellular signalling networks integrate extracellular signals and convert them into cellular responses. In cancer cells, the tightly regulated and fine‐tuned dynamics of information processing in signalling networks is altered leading to uncontrolled cell proliferation, survival and migration. Systems biology combines mathematical modelling with comprehensive, quantitative, time‐resolved data and is most advanced in addressing dynamic properties of intracellular signalling networks. Here, we introduce different modelling approaches and their application to medical systems biology, focusing on the identifiability of parameters in ordinary differential equation models and their importance in network modelling to predict cellular decisions. Two related examples are giv... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5481590 Mon, 05 Dec 2011 05:00:00 +0100 5481590 http://www.medworm.com/index.php?rid=5481589&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02491.x We present a vision for a Biomedical Cloud that draws on progress in the fields of Genomics, Systems Biology, and Biomedical Data Mining. The successful fusion of these areas will merge biomarkers, genetic variants, and environmental variables to build predictive models that will drastically increase the specificity and timeliness of diagnosis for a wide range of common diseases, while delivering accurate predictions about the efficacy of treatment options. However, the amount of data being generated by each of these areas is staggering, as is the task of managing and analyzing it. Adequate computing infrastructure needs to be developed in order to assemble, manage, and mine the enormous and rapidly growing corpus of ‘omics’ data along with clinical information. We have now arrived at ... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5481589 Mon, 05 Dec 2011 05:00:00 +0100 5481589 http://www.medworm.com/index.php?rid=5481588&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02494.x AbstractMetabolism plays a key role in many major human diseases. Generation of high‐throughput omics data has ushered in a new era of systems biology. Genome‐scale metabolic network reconstructions provide a platform to interpret omics data in a biochemically meaningful manner. The release of the global human metabolic network, Recon 1, in 2007 has enabled new systems biology approaches to study human physiology, pathology, and pharmacology. There are currently over 20 publications that utilize Recon 1, including studies of cancer, diabetes, host‐pathogen interactions, heritable metabolic disorders, and off‐target drug binding effects. In this mini‐review, we focus on the reconstruction of the global human metabolic network and four classes of its application. We show that compu... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5481588 Mon, 05 Dec 2011 05:00:00 +0100 5481588 http://www.medworm.com/index.php?rid=5481587&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02493.x AbstractSeveral complex diseases are caused by the malfunction of human metabolism, and deciphering the underlying molecular mechanisms can elucidate their aetiology. Systems biology is an integrative approach combining experimental and computational biology to identify and describe the molecular mechanisms of complex biological systems. Systems medicine has the potential to elucidate the onset and progression of complex metabolic diseases through the use of computational approaches. Advances in biotechnology have resulted in the provision of high‐throughput data, which provide information about different metabolic processes. The systems medicine approach can utilize such data to reconstruct genome‐scale metabolic models which can be used to study the function of specific enzymes and p... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5481587 Mon, 05 Dec 2011 05:00:00 +0100 5481587 http://www.medworm.com/index.php?rid=5481586&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02498.x AbstractA grand challenge impeding optimal treatment outcomes for cancer patients arises from the complex nature of the disease: the cellular heterogeneity, the myriad of dysfunctional molecular and genetic networks as results of genetic (somatic) and environmental perturbations. Systems biology, with its holistic approach to understanding fundamental principles in biology, and the empowering technologies in genomics, proteomics, single‐cell analysis, microfluidics, and computational strategies, enables a comprehensive approach to medicine, which strives to unveil the pathogenic mechanisms of diseases, identify disease biomarkers and begin thinking about new strategies for drug target discovery. The integration of multi‐dimensional high throughput “omics” measurements from tumor ti... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5481586 Mon, 05 Dec 2011 05:00:00 +0100 5481586 http://www.medworm.com/index.php?rid=5481585&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02497.x AbstractTo develop novel strategies for prevention and treatment of dyslipidaemia, it is essential to understand the pathophysiology of dyslipoproteinaemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labelled with stable isotopes and mathematical modelling provides a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering understanding of the pathogenesis of dyslipoproteinaemia. (Source: Journal of Internal Med... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5481585 Thu, 01 Dec 2011 05:00:00 +0100 5481585 http://www.medworm.com/index.php?rid=5463519&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02496.x AbstractCurrent vaccines primarily work by inducing protective antibodies. However, in many infections like HIV, malaria and tuberculosis as well as cancers there remains a need for durable and protective T‐cell immunity. Here, we summarize our efforts to develop a safe T‐cell based protein vaccine that exploits the pivotal role of dendritic cells (DC) in initiating adaptive immunity. Focusing on HIV, gag‐p24 protein antigen is introduced into a monoclonal antibody (mAb) that efficiently and specifically targets the DEC‐205 antigen uptake receptor on DC. When administered together with synthetic double stranded RNA, polyriboinosinic:polyribocytidylic acid (poly IC) or its analogue poly ICLC (poly IC stabilized with carboxymethylcellulose and poly‐L‐lysine), as adjuvant, HIV gag... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5463519 Thu, 01 Dec 2011 05:00:00 +0100 5463519 http://www.medworm.com/index.php?rid=5566936&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02496.x Abstract.  Trumpfheller C, Longhi MP, Caskey M, Idoyaga J, Bozzacco L, Keler T, Schlesinger SJ, Steinman RM (The Rockefeller University, New York, NY; and Celldex Therapeutics, Phillipsburg, NJ; USA). Dendritic cell‐targeted protein vaccines: a novel approach to induce T‐cell immunity (Review). J Intern Med 2012; doi: 10.1111/j.1365‐2796.2011.02496.x.Current vaccines primarily work by inducing protective antibodies. However, in many infections like HIV, malaria and tuberculosis as well as cancers, there remains a need for durable and protective T‐cell immunity. Here, we summarize our efforts to develop a safe T‐cell–based protein vaccine that exploits the pivotal role of dendritic cells (DC) in initiating adaptive immunity. Focusing on HIV, gag‐p24 protein antigen is introd... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5566936 Tue, 29 Nov 2011 05:00:00 +0100 5566936 http://www.medworm.com/index.php?rid=5555985&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02495.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5555985 Tue, 29 Nov 2011 05:00:00 +0100 5555985 http://www.medworm.com/index.php?rid=5463520&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02495.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5463520 Tue, 29 Nov 2011 05:00:00 +0100 5463520 http://www.medworm.com/index.php?rid=5446286&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02489.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5446286 Sat, 26 Nov 2011 02:20:42 +0100 5446286 http://www.medworm.com/index.php?rid=5446288&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02487.x AbstractRonquist G (Department of Internal Medicine, Clinical Chemistry, University Hospital, Uppsala, Sweden) Prostasomes – mediators of intercellular communication (Review). J Intern Med 2011Prostasomes are nanosized microvesicles secreted by acinar epithelial cells of the prostate gland. Furthermore, they are intracellular microvesicles inside another larger vesicle, a so‐called storage vesicle, equivalent to multivesicular bodies of late endosomal origin. Prostasomes are thought to play an important role in intercellular communication by direct interaction primarily between the immobile acinar cells of the prostate gland and the mobile spermatozoa. Prostasomes transfer not only membrane components but also genetic material to spermatozoa. They are rich in various transferable bioac... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5446288 Thu, 24 Nov 2011 05:00:00 +0100 5446288 http://www.medworm.com/index.php?rid=5446287&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02488.x Conclusion:  The presence of stress factors in the history of CFS patients is associated with severe oxidative stress and the suppression of protective HSP27 and HSP70 responses to exercise. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5446287 Thu, 24 Nov 2011 05:00:00 +0100 5446287 http://www.medworm.com/index.php?rid=5435948&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02478.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5435948 Wed, 23 Nov 2011 02:04:44 +0100 5435948 http://www.medworm.com/index.php?rid=5435947&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02461.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5435947 Wed, 23 Nov 2011 02:04:43 +0100 5435947 http://www.medworm.com/index.php?rid=5435946&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02420.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5435946 Wed, 23 Nov 2011 02:04:27 +0100 5435946 http://www.medworm.com/index.php?rid=5426812&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02485.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5426812 Thu, 17 Nov 2011 05:00:00 +0100 5426812 http://www.medworm.com/index.php?rid=5555984&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02484.x Conclusions.  tHcy, holoTC and folate levels are related to cognitive performance 7 years later even in nondemented elderly subjects. Randomized trials are needed to determine the impact of vitamin B12 and folate supplementation on preventing cognitive decline in the elderly. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5555984 Sat, 12 Nov 2011 05:00:00 +0100 5555984 http://www.medworm.com/index.php?rid=5481592&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02482.x Conclusions.  In an analysis of European data, we found both weight gain and weight loss to be associated with the onset of job strain, consistent with a ‘U’‐shaped cross‐sectional association between job strain and BMI. These associations were relatively modest; therefore, it is unlikely that intervention to reduce job strain would be effective in combating obesity at a population level. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5481592 Fri, 11 Nov 2011 05:00:00 +0100 5481592 http://www.medworm.com/index.php?rid=5403976&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02481.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5403976 Fri, 11 Nov 2011 05:00:00 +0100 5403976 http://www.medworm.com/index.php?rid=5403975&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02482.x Conclusions:  In an analysis of European data, we found both weight gain and weight loss to be associated with the onset of job strain, consistent with a ‘U’‐shaped cross‐sectional association between job strain and BMI. These associations were relatively modest, therefore it is unlikely that intervention to reduce job strain would be effective in combating obesity at a population level. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5403975 Fri, 11 Nov 2011 05:00:00 +0100 5403975 http://www.medworm.com/index.php?rid=5463521&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02479.x Conclusion.  The CABR score, derived from adding the anti‐ApoA‐1 IgG/anti‐PC IgM ratio to the NSTEMI‐TIMI score, could be a useful measure to rule out NSTEMI in patients presenting with ACP at the emergency department without electrocardiographic changes. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5463521 Mon, 07 Nov 2011 05:00:00 +0100 5463521 http://www.medworm.com/index.php?rid=5394390&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02479.x Conclusion:  The CABR score, derived from adding the anti‐ApoA‐1 IgG/anti‐PC IgM ratio to the NSTEMI‐TIMI score, could be a useful measure to rule out NSTEMI in patients presenting with ACP at the emergency department without electrocardiographic changes. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5394390 Mon, 07 Nov 2011 05:00:00 +0100 5394390 http://www.medworm.com/index.php?rid=5426811&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02486.x Conclusion:  Both conventional risk factors of CVD and living in a city centre are independently associated with the presence of CAC in asymptomatic middle‐aged subjects. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5426811 Tue, 01 Nov 2011 04:00:00 +0100 5426811 http://www.medworm.com/index.php?rid=5403974&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02484.x Conclusions:  tHcy, holoTC, and folate measured 7 years earlier are related to cognitive performance even in non‐demented elderly. Randomized trials are needed to determine the impact of vitamin B12 and folate supplementations on preventing cognitive decline in the elderly. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5403974 Tue, 01 Nov 2011 04:00:00 +0100 5403974 http://www.medworm.com/index.php?rid=5394389&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02480.x Conclusions:  Low‐grade systolic murmur was detected at heart auscultation in 21.9% of apparently healthy middle‐aged men. Men with low‐grade murmur had an increased risk of AVR, but no increase in risk of CVD death. Only 1.6% of men had moderate‐grade murmur; these men had a very high risk of AVR and a 1.5‐fold albeit non‐significant increase in risk of CVD death. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5394389 Tue, 01 Nov 2011 04:00:00 +0100 5394389 http://www.medworm.com/index.php?rid=5371872&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02477.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5371872 Tue, 01 Nov 2011 04:00:00 +0100 5371872 http://www.medworm.com/index.php?rid=5353540&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02475.x Conclusions:  In patients with hemochromatosis, the increased risk of cardiomyopathy is much more pronounced than that of IHD, which is barely elevated. FDRs of hemochromatosis patients are not at increased risk of cardiomyopathy or IHD. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5353540 Thu, 27 Oct 2011 14:31:58 +0100 5353540 http://www.medworm.com/index.php?rid=5446289&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02475.x Conclusions  In patients with haemochromatosis, the increased risk of cardiomyopathy is much more pronounced than that of IHD, which is barely elevated. FDRs of haemochromatosis patients are not at increased risk of cardiomyopathy or IHD. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5446289 Tue, 25 Oct 2011 04:00:00 +0100 5446289 http://www.medworm.com/index.php?rid=5435945&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02474.x Conclusions.  The results of this study support the findings from the prelicensure clinical trials, providing reassurance that the zoster vaccine is generally safe and well‐tolerated with a small increased risk of allergic reactions in 1–7 days after vaccination. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5435945 Tue, 25 Oct 2011 04:00:00 +0100 5435945 http://www.medworm.com/index.php?rid=5426813&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02476.x Conclusions.  Galectin‐3 is associated with age and risk factors of CV disease, with a strong gender interaction for these correlations. Galectin‐3 predicts all‐cause mortality in the general population. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5426813 Tue, 25 Oct 2011 04:00:00 +0100 5426813 http://www.medworm.com/index.php?rid=5353543&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02476.x Conclusions:  Galectin‐3 is associated with age and risk factors of CV disease, with a strong gender interaction for these correlations. Galectin‐3 predicts all‐cause mortality in the general population. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5353543 Tue, 25 Oct 2011 04:00:00 +0100 5353543 http://www.medworm.com/index.php?rid=5353542&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02473.x Conclusions:  Infections are a risk factor for VTE. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5353542 Tue, 25 Oct 2011 04:00:00 +0100 5353542 http://www.medworm.com/index.php?rid=5353541&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02474.x Conclusions:  The results of this study support the findings from the pre‐licensure clinical trials, providing reassurance that the zoster vaccine is generally safe and well tolerated with a small increased risk of allergic reactions in 1‐7 days after vaccination. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5353541 Tue, 25 Oct 2011 04:00:00 +0100 5353541 http://www.medworm.com/index.php?rid=5341934&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02472.x Conclusions:  This genetic risk score was independently associated with carotid bulb IMT and carotid plaques, providing evidence of an association with early markers of atherosclerosis. This might imply that the genetic myocardial infarction risk conferred by the score is related to early atherosclerosis and that the risk score may identify at an early stage candidates at risk of developing intermediate phenotypes of atherosclerosis. Further studies should test whether assessing the genetic score could be valuable for early treatment decisions in these subjects. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5341934 Sun, 23 Oct 2011 17:39:29 +0100 5341934 http://www.medworm.com/index.php?rid=5328892&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02466.x Conclusions:  BA synthesis has a wide inter‐individual variation, is lower in women than in men, and is correlated positively with serum TGs. High BA production is frequently linked to hypertriglyceridaemia. Age‐related hypercholesterolaemia is not associated with changes in BA or cholesterol production, nor to an increase in cholesterol absorption. In humans, the circulating level of FGF19 may regulate hepatic BA production under fasting conditions. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5328892 Wed, 19 Oct 2011 12:30:09 +0100 5328892 http://www.medworm.com/index.php?rid=5320005&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02463.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5320005 Sun, 16 Oct 2011 04:24:45 +0100 5320005 http://www.medworm.com/index.php?rid=5320003&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02464.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5320003 Sun, 16 Oct 2011 04:23:04 +0100 5320003 http://www.medworm.com/index.php?rid=5371873&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02464.x Sinnaeve PR, Brueckmann M, Clemens A, Oldgren J, Eikelboom J, Healey JS (University Hospitals Leuven, Leuven, Belgium; Global Clinical Development and Medical Affairs, Ingelheim am Rhein, Germany; Uppsala University, Uppsala, Sweden; and Population Health Research Institute, Hamilton, Canada). Stroke prevention in elderly patients with atrial fibrillation: challenges for anticoagulation (Review). J Intern Med 2011; doi: 10.1111/j.1365‐2796.2011.02464.x.Abstract.  Elderly patients with atrial fibrillation (AF), who constitute almost half of all AF patients, are at increased risk of stroke. Anticoagulant therapies, especially vitamin K antagonists (VKA), reduce the risk of stroke in all patients including the elderly but are frequently under‐used in older patients. Failure to initiate ... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5371873 Thu, 13 Oct 2011 04:00:00 +0100 5371873 http://www.medworm.com/index.php?rid=5320004&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02471.x Conclusion:  Our findings suggest that both eGFR and PTH are significantly associated with vitamin D metabolism in men without known CKD. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5320004 Thu, 13 Oct 2011 04:00:00 +0100 5320004 http://www.medworm.com/index.php?rid=5309362&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02468.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5309362 Tue, 11 Oct 2011 04:00:00 +0100 5309362 http://www.medworm.com/index.php?rid=5309361&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02469.x Conclusions:  s‐cTnI is a strong predictor of short‐ and long‐term prognosis in AHF that helps to reclassify patients in terms of mortality risk. Detectable levels of s‐cTnI, even within the normal range, are independently associated with mortality. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5309361 Tue, 11 Oct 2011 04:00:00 +0100 5309361 http://www.medworm.com/index.php?rid=5291315&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02467.x Conclusions:  No autoimmune safety signal was found in females vaccinated with HPV4. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5291315 Tue, 04 Oct 2011 04:00:00 +0100 5291315 http://www.medworm.com/index.php?rid=5309360&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02470.x Conclusions:  ALys is a disease of the gastrointestinal tract, liver and kidneys which has a slow natural history. There was a clear family history in all cases within this cohort, demonstrating a high clinical penetrance in the presence of an amyloidogenic lysozyme mutation. There is currently no amyloid‐specific therapy for the condition which is managed symptomatically. OLT and RTx appear to be successful treatments for patients with liver rupture or end‐stage renal disease respectively, with excellent outcomes in terms of medium‐term graft function and patient survival. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5309360 Sat, 01 Oct 2011 04:00:00 +0100 5309360 http://www.medworm.com/index.php?rid=5291314&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02465.x Conclusions:  Type 2 diabetes and enlarged waist circumference interact to impact on plasma PLTP activity. Diabetes may also amplify the association between plasma PLTP activity and common PLTP gene variations. Our findings support the hypothesis that diabetes–environment and diabetes–gene interactions govern plasma PLTP activity. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5291314 Sat, 01 Oct 2011 04:00:00 +0100 5291314 http://www.medworm.com/index.php?rid=5256019&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02462.x Abstract“The big C”, a common euphemism for cancer, has loomed large on the collective psyche of the mankind for centuries, not least because of the relative dearth of effective treatment against this disease but its ability to relentlessly evade them and come back to haunt us. However, the struggle against cancer took a decisive turn in 1971 when a relentless campaigning by health activists eventually led to signing of the National Cancer Act in the United States, an unprecedented event in the history of diseases. As we commemorate the 40th anniversary of the signing of that historic legislation, an assessment of the progress against cancer would naturally help us understand how we have fared so far in this struggle, and guide us in our efforts to re‐strategize and re‐deploy our l... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5256019 Mon, 26 Sep 2011 18:37:35 +0100 5256019 http://www.medworm.com/index.php?rid=5341936&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02460.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5341936 Fri, 23 Sep 2011 04:00:00 +0100 5341936 http://www.medworm.com/index.php?rid=5341935&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02462.x Tiwari AK, Roy HK (NorthShore University HealthSystem; Evanston, IL, USA). Progress against Cancer (1971–2011): How far have we come? (Historical Perspectives). J Intern Med 2011; doi: 10.1111/j.1365‐2796.2011.02462.x.Abstract.  ‘The big C’, a common euphemism for cancer, has loomed large on the collective psyche of the mankind for centuries, not least because of the relative dearth of effective treatment against this disease but its ability to relentlessly evade them and come back to haunt us. However, the struggle against cancer took a decisive turn in 1971 when a relentless campaigning by health activists eventually led to signing of the National Cancer Act in the United States, an unprecedented event in the history of diseases. As we commemorate the 40th anniversary of the si... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5341935 Fri, 23 Sep 2011 04:00:00 +0100 5341935 http://www.medworm.com/index.php?rid=5256022&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02459.x Conclusion:  The level of serum KL‐6 may serve as measure of ILD in patients with PM/DM, and is a promising biomarker for use in clinical practice to assess clinical response to treatment. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5256022 Fri, 23 Sep 2011 04:00:00 +0100 5256022 http://www.medworm.com/index.php?rid=5256021&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02460.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5256021 Fri, 23 Sep 2011 04:00:00 +0100 5256021 http://www.medworm.com/index.php?rid=5256020&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02461.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5256020 Fri, 23 Sep 2011 04:00:00 +0100 5256020 http://www.medworm.com/index.php?rid=5231112&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02431.x Abstract.  Maroso M., Balosso S., Ravizza T., Liu J., Bianchi M.E., Vezzani A. (Mario Negri Institute for Pharmacological Research, Milano; and San Raffaele University and Research Institute Milano; Italy). Interleukin‐1 type 1 receptor/Toll‐like receptor signalling in epilepsy: the importance of IL‐1beta and high‐mobility group box 1 (Symposium). J Intern Med 2011; 270: 319–326.Inflammatory processes in brain tissue have been described in human epilepsy of various aetiologies and in experimental models of seizures. This, together with the anticonvulsant properties of anti‐inflammatory therapies both in clinical and in experimental settings, highlights the important role of brain inflammation in the aetiopathogenesis of seizures. Preclinical investigations in experimental mod... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5231112 Mon, 19 Sep 2011 16:07:10 +0100 5231112 http://www.medworm.com/index.php?rid=5231111&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02432.x Abstract.  Urbonaviciute V, Voll RE (Friedrich‐Alexander University of Erlangen‐Nuremberg, Erlangen; and University Medical Centre Freiburg, Freiburg/Breisgau; Germany). High‐mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus (Symposium). J Intern Med 2011; 270: 309–318.High‐mobility group box 1 (HMGB1) protein is a nuclear DNA‐binding protein, which functions as an alarmin when released from cells. Recent studies implicate extracellular HMGB1 in the pathogenesis of systemic lupus erythematosus (SLE), a prototypical autoimmune disease characterized by the formation of multiple autoantibodies, especially those directed against nucleosomes and double‐stranded (ds)DNA. Elevated concentrations of H... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5231111 Mon, 19 Sep 2011 16:07:09 +0100 5231111 http://www.medworm.com/index.php?rid=5231110&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02433.x Abstract.  Yanai H, Ban T, Taniguchi T (The University of Tokyo; and Japan Science and Technology Agency; Tokyo, Japan). Essential role of high‐mobility group box proteins in nucleic acid‐mediated innate immune responses (Symposium). J Intern Med 2011; 270: 301–308.Central to protective and pathological immunity is the activation of innate immune responses upon recognition of nucleic acids by transmembrane Toll‐like receptors (TLRs) and cytosolic receptors. In mammals, the transmembrane pattern recognition receptors TLR3, TLR7 and TLR9 recognize double‐stranded RNA, single‐stranded RNA and hypomethylated DNA, respectively, while the retinoic acid‐inducible gene‐I (RIG‐I)‐like receptors (RLRs), RIG‐I and MDA5 are known to be cytosolic RNA‐sensing receptors. In addi... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5231110 Mon, 19 Sep 2011 16:07:08 +0100 5231110 http://www.medworm.com/index.php?rid=5231109&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02419.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5231109 Mon, 19 Sep 2011 16:07:05 +0100 5231109 http://www.medworm.com/index.php?rid=5231102&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02458.x AbstractThe World Health Organization (WHO) and United Nations Programme on HIV/AIDS (UNAIDS) estimated that an additional 370,000 new human immunodeficiency virus type 1 (HIV‐1) infections occurred in children in 2009, mainly through mother‐to‐child transmission (MTCT). Intrapartum transmission contributes to approximately 20–25% of infections, in utero transmission to 5–10% and postnatal transmission to an additional 10–15% of cases. MTCT accounts for only a few hundred infected newborns in those countries in which services are established for voluntary counselling and testing of pregnant women and a supply of antiretroviral drugs is available throughout pregnancy with recommendations for elective Caesarean section and avoidance of breastfeeding. The single‐dose nevirapine ... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5231102 Mon, 19 Sep 2011 16:05:57 +0100 5231102 http://www.medworm.com/index.php?rid=5231105&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02455.x AbstractThere is ample evidence for intra‐patient evolution of the human immunodeficiency virus type 1 (HIV‐1) biological phenotype during the pathogenic process. Evolution often involves switch of coreceptor use from CCR5 to CXCR4, but change to more flexible use of CCR5 occurs over time even in patients with maintained CCR5 use. The increasing use of entry inhibitors in the clinic, often specific for one or the other HIV‐1 coreceptor or with different binding properties to CCR5, calls for virus testing in patients prior to treatment initiation. Cell lines expressing CCR5/CXCR4 chimeric receptors are tools for testing viruses for mode of CCR5 use. It is conceivable that small‐molecule entry inhibitors that differentially bind to CCR5 can be matched for best effect against HIV‐1 ... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5231105 Mon, 19 Sep 2011 04:00:00 +0100 5231105 http://www.medworm.com/index.php?rid=5231104&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02456.x Abstract“Test and treat” is a strategy in which widespread screening for human immunodeficiency virus (HIV) is followed by immediate antiretroviral therapy for those testing positive, thereby potentially reducing infectiousness in larger cohorts of infected patients. However, there is a concern that test and treat could lead to increased levels of transmissible drug‐resistant HIV, especially if viral load and/or drug resistance is not routinely monitored. Reviews of the existing literature show that up to now, even in the absence of laboratory tests, drug resistance has not created major problems in sub‐Saharan Africa. Here we discuss the current evidence for the effectiveness of a preventive test and treat approach and the challenges and implications for daily clinical practice an... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5231104 Mon, 19 Sep 2011 04:00:00 +0100 5231104 http://www.medworm.com/index.php?rid=5231103&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02457.x AbstractRecent studies demonstrate that suppressive therapy can drive HIV‐1 RNA levels to less than 50 copies/ml in patient plasma. Yet, ultrasensitive assays show that most patients continue to harbor low‐level persistent viremia. Treatment intensification studies indicate that low‐level viremia could arise from several different sources. These sources include: 1) long‐lived HIV‐infected cells that replicate and produce virus; 2) ongoing replication cycles in cells located in sanctuary sites where drug levels are suboptimal; and/or 3) proliferation of latently‐infected cells with regeneration of a stable reservoir of slowly‐dividing infected cells. A well‐defined latent reservoir of HIV is memory CD4+ T‐cells where latency is established when an activated CD4+ T‐cell b... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5231103 Mon, 19 Sep 2011 04:00:00 +0100 5231103 http://www.medworm.com/index.php?rid=5231107&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02453.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5231107 Wed, 14 Sep 2011 04:00:00 +0100 5231107 http://www.medworm.com/index.php?rid=5231106&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02454.x AbstractMicrobicides are products that are designed for application at vaginal or rectal mucosae to inhibit or block early events in HIV infection and thereby prevent transmission of HIV. Currently, the most advanced microbicides in the development pipeline are based on highly active anti‐retroviral drugs (ARVs). Significant protection of women by vaginally‐applied tenofovir gel, demonstrated in the CAPRISA 004 trial, has provided proof‐of‐concept that microbicides can be effective. The rationale for investigating ARVs and other compounds as vaginal or rectal microbicides is discussed together with approaches to improve efficacy by development of combination microbicides and by new formulations that may increase user acceptance. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5231106 Wed, 14 Sep 2011 04:00:00 +0100 5231106 http://www.medworm.com/index.php?rid=5189601&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02450.x AbstractGenetic studies of domestic animals are of general interest because there is more phenotypic diversity to explore in these species than in any experimental organism. Some mutations with favourable phenotypic effects have been highly enriched and gone through selective sweeps during the process of domestication and selective breeding. Three such selective sweeps are described in this review. All three mutations are intronic and constitute cis‐acting regulatory mutations. Two of the mutations constitute structural changes (one duplication and one copy number expansion). These examples illustrate a general trend that non‐coding mutations and structural changes have both contributed significantly to the evolution of phenotypic diversity in domestic animals. How the molecular charac... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5189601 Fri, 02 Sep 2011 23:00:00 +0100 5189601 http://www.medworm.com/index.php?rid=5216548&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02452.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5216548 Thu, 01 Sep 2011 04:00:00 +0100 5216548 http://www.medworm.com/index.php?rid=5189600&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02451.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5189600 Wed, 31 Aug 2011 23:00:00 +0100 5189600 http://www.medworm.com/index.php?rid=5266692&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02449.x Conclusion.  The incorporation of ERE SNPs into models with known predictors might improve outcome prediction in patients with prostate cancer receiving ADT. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5266692 Wed, 31 Aug 2011 04:00:00 +0100 5266692 http://www.medworm.com/index.php?rid=5189603&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02448.x Conclusion:  Patients with CD seem to be at a moderately increased risk of COPD both before and after CD diagnosis. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5189603 Tue, 30 Aug 2011 23:00:00 +0100 5189603 http://www.medworm.com/index.php?rid=5189602&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02449.x Conclusion:  The incorporation of ERE SNPs into models with known predictors might improve outcome prediction in prostate cancer patients receiving ADT. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5189602 Tue, 30 Aug 2011 23:00:00 +0100 5189602 http://www.medworm.com/index.php?rid=5173361&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02447.x Conclusions: ADRB2 Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of ischaemic heart disease among women in the general population. These findings, particularly for homozygotes, are novel. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5173361 Tue, 30 Aug 2011 00:13:16 +0100 5173361 http://www.medworm.com/index.php?rid=5266693&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02447.x Conclusions. ADRB2 Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of IHD amongst women in the general population. These findings, particularly for homozygotes, are novel. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5266693 Sun, 28 Aug 2011 04:00:00 +0100 5266693 http://www.medworm.com/index.php?rid=5167508&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02442.x Conclusions:  In this cross‐sectional study of non‐diabetic subjects, sCD36 was significantly associated with indices of insulin resistance, carotid atherosclerosis and fatty liver. Prospective studies are needed to further evaluate the role of sCD36 in the inter‐relationship between atherosclerosis, fatty liver and insulin resistance. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5167508 Sat, 27 Aug 2011 23:29:25 +0100 5167508 http://www.medworm.com/index.php?rid=5173362&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02446.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5173362 Sat, 27 Aug 2011 23:00:00 +0100 5173362 http://www.medworm.com/index.php?rid=5231108&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02442.x Conclusions.  In this cross‐sectional study of nondiabetic subjects, sCD36 was significantly associated with indices of insulin resistance, carotid atherosclerosis and fatty liver. Prospective studies are needed to further evaluate the role of sCD36 in the inter‐relationship between atherosclerosis, fatty liver and insulin resistance. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5231108 Thu, 25 Aug 2011 04:00:00 +0100 5231108 http://www.medworm.com/index.php?rid=5153187&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02441.x Conclusions:  ZAG is released from human WAT but this tissue does not contribute significantly to the circulating levels. WAT‐secreted ZAG correlates with nutritional status but not with fat mass in both cancer and non‐malignant conditions. Adipose ZAG is therefore a local factor activated primarily by the catabolic state per se. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5153187 Thu, 25 Aug 2011 00:15:33 +0100 5153187 http://www.medworm.com/index.php?rid=5189604&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02441.x Conclusions.  ZAG is released from human WAT, but this tissue does not contribute significantly to the circulating levels. WAT‐secreted ZAG correlates with nutritional status but not with fat mass in both cancer and nonmalignant conditions. Adipose ZAG is therefore a local factor activated primarily by the catabolic state per se. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5189604 Tue, 23 Aug 2011 23:00:00 +0100 5189604 http://www.medworm.com/index.php?rid=5136559&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02440.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5136559 Wed, 17 Aug 2011 14:01:46 +0100 5136559 http://www.medworm.com/index.php?rid=5153190&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02443.x Conclusions:  %BF appears to predict hip fracture risk in women with an effect size comparable to that of bone density as measured by heel ultrasound. This effect was not observed in men. Understanding the differences in relationships between different indices of obesity as well as sex differences may help to elucidate the metabolic and other underlying mechanisms involved in bone health and fracture risk. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5153190 Tue, 16 Aug 2011 23:00:00 +0100 5153190 http://www.medworm.com/index.php?rid=5153189&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02444.x Conclusions:  sCD27 may act to enhance immunoglobulin production and differentiation of activated memory or recently antigen‐experienced B cells, thus providing an activation signal to antigen‐experienced B cells. This mechanism may operate during autoimmune and chronic infectious diseases, situations in which continuous immune activation leads to upregulation of CD70 expression and increased sCD27 cleavage. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5153189 Tue, 16 Aug 2011 23:00:00 +0100 5153189 http://www.medworm.com/index.php?rid=5153188&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02445.x AbstractDuring gametogenesis, the female and male germ cells undergo a process whereby imprinting marks are erased from the genome. During the later stages of germ‐cell development, the methylation marks of the female and male germ lines are re‐established. A second phase of demethylation of the genome occurs at the time of fertilization, and during development of the early embryo. Assisted reproductive technology involves several steps that subject the gametes and early developing embryos to environmental stress, and this is the primary reason for an increased interest in the putative link between these techniques and imprinting disorders. Although animal studies support a link between assisted reproductive techniques and imprinting disorders, via altered methylation patterns, data in... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5153188 Tue, 16 Aug 2011 23:00:00 +0100 5153188 http://www.medworm.com/index.php?rid=5167509&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02440.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5167509 Mon, 15 Aug 2011 23:00:00 +0100 5167509 http://www.medworm.com/index.php?rid=5136560&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02439.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5136560 Mon, 15 Aug 2011 23:00:00 +0100 5136560 http://www.medworm.com/index.php?rid=5167510&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02437.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5167510 Thu, 04 Aug 2011 23:00:00 +0100 5167510 http://www.medworm.com/index.php?rid=5101713&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02436.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5101713 Thu, 04 Aug 2011 23:00:00 +0100 5101713 http://www.medworm.com/index.php?rid=5101712&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02437.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5101712 Thu, 04 Aug 2011 23:00:00 +0100 5101712 http://www.medworm.com/index.php?rid=5189605&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02435.x Conclusions.  A model consisting of five factors can be used to estimate and stratify the probability of death for individuals The model is most useful for long‐term prognosis in an HD population with survival prospects of more than 1 year. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5189605 Tue, 02 Aug 2011 23:00:00 +0100 5189605 http://www.medworm.com/index.php?rid=5101711&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02438.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5101711 Sun, 31 Jul 2011 23:00:00 +0100 5101711 http://www.medworm.com/index.php?rid=5092664&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02435.x Conclusions:  A model consisting of five factors can be used to estimate and stratify the probability of death for individuals The model is most useful for long‐term prognosis in an HD population with survival prospects of more than 1 year. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5092664 Sun, 31 Jul 2011 23:00:00 +0100 5092664 http://www.medworm.com/index.php?rid=5084359&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02434.x Conclusion:  A slow 2‐min HRR after a cycle ergometer exercise test was an independent predictor of death in healthy middle‐aged men after accounting for demographic and clinical characteristics. However, it was no longer predictive after accounting for chronotropic response and exercise capacity. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5084359 Sun, 31 Jul 2011 23:00:00 +0100 5084359 http://www.medworm.com/index.php?rid=5074944&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02433.x ABSTRACTCentral to protective and pathological immunity is the activation of innate immune responses upon recognition of nucleic acids by transmembrane Toll‐like receptors (TLRs) and cytosolic receptors. In mammals, the transmembrane pattern recognition receptors TLR3, TLR7 and TLR9 recognize double‐stranded RNA, single‐stranded RNA and hypomethylated DNA, respectively, while the RIG‐I‐like receptors (RLRs), RIG‐I and MDA5 are known to be cytosolic RNA‐sensing receptors. In addition, cytosolic DNA‐sensing receptors that include DAI, RIG‐I/MDA5 and AIM2 also trigger innate immune responses. High‐mobility group box (HMGB)1, 2 and 3 proteins, which also bind immunogenic nucleic acids, are generally involved in the nucleic acid receptor‐mediated activation of innate immun... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5074944 Fri, 29 Jul 2011 23:05:25 +0100 5074944 http://www.medworm.com/index.php?rid=5074948&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02429.x Conclusion:  CFS patients have markedly reduced cardiac mass and blood pool volumes, particularly end diastolic volume: this results in significant impairments in stroke volume and cardiac output compared to controls. The CFS group appeared to have a delay in the release of torsion. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5074948 Tue, 26 Jul 2011 23:00:00 +0100 5074948 http://www.medworm.com/index.php?rid=5074947&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02431.x AbstractInflammatory processes in brain tissue have been described in human epilepsy of various aetiologies and in experimental models of seizures. This, together with the anticonvulsant properties of anti‐inflammatory therapies both in clinical and experimental settings, highlights the important role of brain inflammation in the aetiopathogenesis of seizures. Pre‐clinical investigations in experimental models using pharmacological and genetic tools have identified a significant contribution of interleukin‐1 (IL‐1) type 1 receptor/Toll‐like receptor (IL‐1R/TLR) signalling to seizure activity. This signalling can be activated by ligands associated with infections (pathogen‐associated molecular patterns (PAMPs)) or by endogenous molecules, such as proinflammatory cytokines (e.g... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5074947 Tue, 26 Jul 2011 23:00:00 +0100 5074947 http://www.medworm.com/index.php?rid=5074946&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02430.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5074946 Tue, 26 Jul 2011 23:00:00 +0100 5074946 http://www.medworm.com/index.php?rid=5074945&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02432.x AbstractHigh‐mobility group box 1 (HMGB1) protein is a nuclear DNA‐binding protein, which functions as an alarmin when released from cells. Recent studies implicate extracellular HMGB1 in the pathogenesis of systemic lupus erythematosus (SLE), a prototypical autoimmune disease characterized by the formation of multiple autoantibodies, especially those directed against nucleosomes and double stranded (ds)DNA. Elevated concentrations of HMGB1 are observed in sera as well as in skin lesions of patients with lupus. Of importance, serum HMGB1 and anti‐HMGB1 autoantibody levels correlate with disease activity. In the blood of patients with SLE, HMGB1 is complexed with nucleosomes, at least partially. Moreover, HMGB1–nucleosome complexes from apoptotic cells activate antigen‐presenting ... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5074945 Tue, 26 Jul 2011 23:00:00 +0100 5074945 http://www.medworm.com/index.php?rid=5046423&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02428.x AbstractThe label “chronic fatigue syndrome” (CFS) has persisted for many years because of lack of knowledge of the etiological agents and of the disease process. In view of more recent research and clinical experience that strongly point to widespread inflammation and multisystemic neuropathology, it is more appropriate and correct to use the term “myalgic encephalomyelitis”(ME) because it indicates an underlying pathophysiology. It is also consistent with the neurological classification of ME in the World Health Organization’s International Classification of Diseases (ICD G93.3). Consequently, an International Consensus Panel consisting of clinicians, researchers, teaching faculty and an independent patient advocate was formed with the purpose of developing criteria based on cu... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5046423 Thu, 21 Jul 2011 21:44:43 +0100 5046423 http://www.medworm.com/index.php?rid=5025689&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02427.x ABSTRACTThe analysis of tissue‐specific expression at both the gene and protein level is vital for understanding human biology and disease. Antibody‐based proteomics provides a strategy for the systematic generation of antibodies against all human proteins to combine with protein profiling in tissues and cells using tissue microarrays, immunohistochemistry and immunofluorescence. The Human Protein Atlas project was launched in 2003 with the aim of creating a map of protein expression patterns in normal cells, tissues and cancer. At present, 11,200 unique proteins corresponding to over 50% of all human protein‐encoding genes have been analysed. All protein expression data, including underlying high‐resolution images, are published on the free and publically available Human Protein A... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5025689 Thu, 14 Jul 2011 17:53:42 +0100 5025689 http://www.medworm.com/index.php?rid=5092665&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02426.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5092665 Thu, 07 Jul 2011 23:00:00 +0100 5092665 http://www.medworm.com/index.php?rid=5115457&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02422.x Conclusion.  Manual and semi‐automated readings of the maximal far wall of the common CIMT images both result in high reproducibility, show similar risk factor relations, rates of change and treatment effects. Hence, choices between semi‐automated and manual reading software for CIMT studies likely should be based on logistical and cost considerations rather than differences in expected data quality when the choice is made to use far wall common CIMT measurements. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5115457 Mon, 04 Jul 2011 23:00:00 +0100 5115457 http://www.medworm.com/index.php?rid=5067431&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02424.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5067431 Mon, 04 Jul 2011 23:00:00 +0100 5067431 http://www.medworm.com/index.php?rid=5004644&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02422.x Conclusion:  Manual and semi‐automated readings of the maximal far wall of the common CIMT images both result in high reproducibility, show similar risk factor relations, rates of change, and treatment effects. Hence, choices between semi‐automated and manual reading software for CIMT studies likely should be based on logistical and cost considerations rather than differences in expected data quality when the choice is made to use far wall common CIMT measurements. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5004644 Mon, 04 Jul 2011 23:00:00 +0100 5004644 http://www.medworm.com/index.php?rid=5004643&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02423.x Conclusion:  In a real‐world PCI population, the combination of PPIs and clopidogrel was associated with a doubling of MI rates after 3 years. Even after correction for confounding factors, concomitant PPI use remained an independent predictor of outcome emphasizing the clinical importance of this drug–drug interaction. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5004643 Mon, 04 Jul 2011 23:00:00 +0100 5004643 http://www.medworm.com/index.php?rid=5004642&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02424.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5004642 Mon, 04 Jul 2011 23:00:00 +0100 5004642 http://www.medworm.com/index.php?rid=5015787&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02426.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5015787 Thu, 30 Jun 2011 23:00:00 +0100 5015787 http://www.medworm.com/index.php?rid=5004641&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02425.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5004641 Thu, 30 Jun 2011 23:00:00 +0100 5004641 http://www.medworm.com/index.php?rid=4996681&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02421.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4996681 Thu, 30 Jun 2011 23:00:00 +0100 4996681 http://www.medworm.com/index.php?rid=4973779&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02418.x Conclusions:  Patients with high levels of VWF had an increased risk of bleeding complications, cardiovascular mortality and all‐cause mortality during OAC treatment. Our findings imply that the use of VWF as a risk marker for thromboembolic events is complicated by the association of VWF with bleeding complications. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4973779 Tue, 28 Jun 2011 16:06:27 +0100 4973779 http://www.medworm.com/index.php?rid=4943329&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02390.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4943329 Sun, 19 Jun 2011 04:09:08 +0100 4943329 http://www.medworm.com/index.php?rid=4943328&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02372.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4943328 Sun, 19 Jun 2011 04:09:05 +0100 4943328 http://www.medworm.com/index.php?rid=4943323&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02417.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4943323 Sun, 19 Jun 2011 04:08:38 +0100 4943323 http://www.medworm.com/index.php?rid=5046424&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02416.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5046424 Thu, 16 Jun 2011 23:00:00 +0100 5046424 http://www.medworm.com/index.php?rid=5025691&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02414.x Conclusion.  Our main findings were a lower proportion of regulatory T cells in DR3pos patients, together with the accumulation of AV2S3pos T cells with a highly activated effector phenotype in the lungs of these patients. This may provide for efficient elimination of a harmful antigen in DR3pos patients and could thus help to explain the spontaneous recovery typically seen in these patients. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5025691 Thu, 16 Jun 2011 23:00:00 +0100 5025691 http://www.medworm.com/index.php?rid=5025690&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02415.x Abstract.  McMichael AJ, Lindgren E (The Australian National University, Canberra, Australia; and Karolinska Institute, Stockholm, Sweden). Climate change: present and future risks to health: and necessary responses (Review). J Intern Med 2011; doi: 10.1111/j.1365‐2796.2011.02415.x.Recent observed changes in Earth’s climate, to which humans have contributed substantially, are affecting various health outcomes. These include altered distributions of some infectious disease vectors (ticks at high latitudes, malaria mosquitoes at high altitudes), and an uptrend in extreme weather events and associated deaths, injuries and other health outcomes. Future climate change, if unchecked, will have increasing, mostly adverse, health impacts – both direct and indirect. Climate change will ampl... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=5025690 Thu, 16 Jun 2011 23:00:00 +0100 5025690 http://www.medworm.com/index.php?rid=4943327&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02413.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4943327 Thu, 16 Jun 2011 23:00:00 +0100 4943327 http://www.medworm.com/index.php?rid=4943326&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02414.x Conclusion  Our main findings were a lower proportion of regulatory T cells in DR3pos patients, together with the accumulation of AV2S3pos T cells with a highly activated effector phenotype in the lungs of these patients. This may provide for efficient elimination of a harmful antigen in DR3pos patients, and could thus help to explain the spontaneous recovery typically seen in these patients. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4943326 Thu, 16 Jun 2011 23:00:00 +0100 4943326 http://www.medworm.com/index.php?rid=4943325&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02415.x AbstractRecent observed changes in Earth’s climate, to which humans have contributed substantially, are affecting various health outcomes. These include altered distributions of some infectious disease vectors (ticks at high latitudes, malaria mosquitoes at high altitudes), and an uptrend in extreme weather events and associated deaths, injuries and other health outcomes. Future climate change, if unchecked, will have increasing, mostly adverse, health impacts – both direct and indirect. Climate change will amplify health problems in vulnerable regions, influence infectious disease emergence, affect food yields and nutrition, increase risks of climate‐related disasters, and impair mental health. The health sector should assist society understand the risks to health and the needed res... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4943325 Thu, 16 Jun 2011 23:00:00 +0100 4943325 http://www.medworm.com/index.php?rid=4943324&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02416.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4943324 Thu, 16 Jun 2011 23:00:00 +0100 4943324 http://www.medworm.com/index.php?rid=4996682&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02409.x Abstract.  Gray J (Norfolk and Norwich University Hospital, Norwich, UK). Rotavirus vaccines: safety, efficacy and public health impact (Foresight). J Intern Med 2011; doi: 10.1111/j.1365‐2796.2011.02409.x.Rotaviruses are the cause of acute gastroenteritis, and disease is widespread amongst infants and young children throughout the world. Also, rotavirus is associated with significant mortality in developing countries with more than 500 000 children dying each year as a result of the severe dehydration associated with rotavirus disease. Efforts have been ongoing for more than 30 years to develop a safe and effective rotavirus vaccine. Currently, two vaccines, RotaRix and RotaTeq, have been licensed for use in many countries throughout the world following comprehensive safety and ef... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4996682 Sun, 12 Jun 2011 23:00:00 +0100 4996682 http://www.medworm.com/index.php?rid=4990228&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02411.x Conclusions.  Although conclusions regarding causal relationships based on epidemiological observations need to be made with caution, our findings suggest the possibility that anti‐MGO‐apoB100 IgM may be protective in diabetic vasculopathy. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4990228 Sun, 12 Jun 2011 23:00:00 +0100 4990228 http://www.medworm.com/index.php?rid=4930288&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02409.x AbstractRotaviruses are the cause of acute gastroenteritis and disease is widespread among infants and young children throughout the world. Also, rotavirus is associated with significant mortality in developing countries with more that 500,000 children dying each year as a result of the severe dehydration associated with rotavirus disease. Efforts have been ongoing for more that 30 years to develop a safe and effective rotavirus vaccine. Currently, two vaccines, RotaRix (GSK, Belgium) and RotaTeq (Merck, USA), have been licensed for use in many countries throughout the world following comprehensive safety and efficiency trials. Monitoring their effectiveness post licensure has confirmed that their incorporation into early childhood vaccination schedules can significantly prevent severe rot... Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4930288 Sun, 12 Jun 2011 23:00:00 +0100 4930288 http://www.medworm.com/index.php?rid=4930287&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02410.x AbstractRadiation therapy (RT) alone and more recently in combination with chemotherapy (combined modality therapy; CMT) has been the cornerstone of curative treatment for early stage Hodgkin lymphoma (HL) for over 40 years. Because of increasing awareness of the late morbidity and mortality associated with RT, recent treatment regimens have attempted to limit its use. Chemotherapy only has been demonstrated to be a treatment option for most patients with localized HL. Current clinical trials have targeted subgroups of such patients who may be at an increased risk of recurrence for addition of limited RT to chemotherapy. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4930287 Sun, 12 Jun 2011 23:00:00 +0100 4930287 http://www.medworm.com/index.php?rid=4930286&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02411.x Conclusions:  Although conclusions regarding causal relationships based on epidemiological observations need to be made with caution, our findings suggest the possibility that anti‐MGO‐apoB100 IgM may be protective in diabetic vasculopathy. (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4930286 Sun, 12 Jun 2011 23:00:00 +0100 4930286 http://www.medworm.com/index.php?rid=4950464&cid=s_28860_49_f&fid=28860&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2796.2011.02408.x (Source: Journal of Internal Medicine) Journal of Internal Medicine journals http://www.medworm.com/rss/comments.php?id=4950464 Wed, 01 Jun 2011 23:00:00 +0100 4950464