Journal of Medicinal Chemistry via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Medicinal Chemistry' source. Thu, 09 Feb 2012 13:01:45 +0100 Contribution of Phosphates and Adenine to the Potency of Adenophostins at the IP3 Receptor: Synthesis of All Possible Bisphosphates of Adenophostin A http://www.medworm.com/index.php?rid=5673204&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2F6CWMUSs8W5o%2Fjm201571p Journal of Medicinal ChemistryDOI: 10.1021/jm201571p (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5673204 Wed, 08 Feb 2012 14:18:07 +0100 5673204 Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1 http://www.medworm.com/index.php?rid=5673205&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FI4bZwkPHK3Y%2Fjm201505p Journal of Medicinal ChemistryDOI: 10.1021/jm201505p (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5673205 Wed, 08 Feb 2012 14:16:01 +0100 5673205 Pyridone Methylsulfone Hydroxamate LpxC Inhibitors for the Treatment of Serious Gram-Negative Infections http://www.medworm.com/index.php?rid=5673206&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2F4DSLOtRB0dY%2Fjm2014875 Journal of Medicinal ChemistryDOI: 10.1021/jm2014875 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5673206 Wed, 08 Feb 2012 13:25:37 +0100 5673206 Aberrant Cyclization Affords a C-6 Modified Cyclic Adenosine 5′-Diphosphoribose Analogue with Biological Activity in Jurkat T Cells http://www.medworm.com/index.php?rid=5673207&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FOX1NoW_pHFk%2Fjm201127y Journal of Medicinal ChemistryDOI: 10.1021/jm201127y (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5673207 Wed, 08 Feb 2012 13:24:29 +0100 5673207 3-Aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: A Novel Template for the Design of Highly Selective A2B Adenosine Receptor Antagonists http://www.medworm.com/index.php?rid=5673208&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FUQ2zTS7NJH8%2Fjm201177b Journal of Medicinal ChemistryDOI: 10.1021/jm201177b (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5673208 Tue, 07 Feb 2012 20:14:25 +0100 5673208 Structure–Activity Relationship of Novel Menaquinone-4 Analogues: Modification of the Side Chain Affects their Biological Activities http://www.medworm.com/index.php?rid=5673209&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2F7IJdvRDBy9k%2Fjm2013166 Journal of Medicinal ChemistryDOI: 10.1021/jm2013166 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5673209 Tue, 07 Feb 2012 20:14:05 +0100 5673209 A Tribute to Joseph G. Cannon, 1926–2011 http://www.medworm.com/index.php?rid=5673210&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FX3d8Zwpe8Eg%2Fjm300081m Journal of Medicinal ChemistryDOI: 10.1021/jm300081m (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5673210 Mon, 06 Feb 2012 16:13:38 +0100 5673210 Synthesis and Biological Activity of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Inhibitors of de Novo Purine Biosynthesis with Selectivity for Cellular Uptake by High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier http://www.medworm.com/index.php?rid=5663770&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FfYLf5h8pUh8%2Fjm201688n Journal of Medicinal ChemistryDOI: 10.1021/jm201688n (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5663770 Fri, 03 Feb 2012 21:00:52 +0100 5663770 5-Imino-1,2,4-Thiadiazoles: First Small Molecules As Substrate Competitive Inhibitors of Glycogen Synthase Kinase 3 http://www.medworm.com/index.php?rid=5663771&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FKBO65JbxFjk%2Fjm201463v Journal of Medicinal ChemistryDOI: 10.1021/jm201463v (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5663771 Fri, 03 Feb 2012 18:36:42 +0100 5663771 Homobivalent Ligands of the Atypical Antipsychotic Clozapine: Design, Synthesis, and Pharmacological Evaluation http://www.medworm.com/index.php?rid=5655667&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2Fm3dB7w6wKxE%2Fjm201420s Journal of Medicinal ChemistryDOI: 10.1021/jm201420s (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5655667 Thu, 02 Feb 2012 19:23:01 +0100 5655667 Correction to Malaria-Infected Mice Are Completely Cured by One 6 mg/kg Oral Dose of a New Monomeric Trioxane Sulfide Combined with Mefloquine http://www.medworm.com/index.php?rid=5655668&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FzKS3P3-5GPM%2Fjm300104m Journal of Medicinal ChemistryDOI: 10.1021/jm300104m (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5655668 Thu, 02 Feb 2012 15:04:11 +0100 5655668 1,4-Dioxane, a Suitable Scaffold for the Development of Novel M3 Muscarinic Receptor Antagonists http://www.medworm.com/index.php?rid=5655669&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FT5t-OwZgwpk%2Fjm2013216 Journal of Medicinal ChemistryDOI: 10.1021/jm2013216 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5655669 Thu, 02 Feb 2012 14:52:36 +0100 5655669 3-Fluoro- and 3,3-Difluoro-3,4-dideoxy-KRN7000 Analogues as New Potent Immunostimulator Agents: Total Synthesis and Biological Evaluation in Human Invariant Natural Killer T Cells and Mice http://www.medworm.com/index.php?rid=5655670&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FMAi-cbt4AOg%2Fjm201368m Journal of Medicinal ChemistryDOI: 10.1021/jm201368m (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5655670 Wed, 01 Feb 2012 16:57:45 +0100 5655670 [1,2,4]Triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: Antagonists of the Wnt Pathway That Inhibit Tankyrases 1 and 2 via Novel Adenosine Pocket Binding http://www.medworm.com/index.php?rid=5655671&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FzYRaSmfET10%2Fjm2011222 Journal of Medicinal ChemistryDOI: 10.1021/jm2011222 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5655671 Wed, 01 Feb 2012 15:24:54 +0100 5655671 Trivalent Ultrashort Lipopeptides are Potent pH Dependent Antifungal Agents http://www.medworm.com/index.php?rid=5655672&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FVbOKHOU1LOo%2Fjm2014474 Journal of Medicinal ChemistryDOI: 10.1021/jm2014474 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5655672 Wed, 01 Feb 2012 14:18:06 +0100 5655672 Ligand-Based Design of a Potent and Selective Inhibitor of Cytochrome P450 2C19 http://www.medworm.com/index.php?rid=5655673&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FornnRRZ8YHo%2Fjm201346g Journal of Medicinal ChemistryDOI: 10.1021/jm201346g (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5655673 Tue, 31 Jan 2012 05:41:37 +0100 5655673 Synthesis and Toxicopharmacological Evaluation of m-Hydroxymexiletine, the First Metabolite of Mexiletine More Potent Than the Parent Compound on Voltage-Gated Sodium Channels http://www.medworm.com/index.php?rid=5655674&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FVyR_-YUs3WY%2Fjm201197z Journal of Medicinal ChemistryDOI: 10.1021/jm201197z (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5655674 Tue, 31 Jan 2012 05:41:00 +0100 5655674 The 1.8 Å Crystal Structure of ACTIBIND Suggests a Mode of Action for T2 Ribonucleases As Antitumorigenic Agents http://www.medworm.com/index.php?rid=5655675&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FKhIxIQHkbMg%2Fjm1015507 Journal of Medicinal ChemistryDOI: 10.1021/jm1015507 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5655675 Tue, 31 Jan 2012 05:40:10 +0100 5655675 A Synthetic Chalcone as a Potent Inducer of Glutathione Biosynthesis http://www.medworm.com/index.php?rid=5643311&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FzvzjrzDOSSU%2Fjm2016073 Journal of Medicinal ChemistryDOI: 10.1021/jm2016073 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5643311 Mon, 30 Jan 2012 20:13:03 +0100 5643311 Diverse Heterocyclic Scaffolds as Allosteric Inhibitors of AKT http://www.medworm.com/index.php?rid=5643315&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2F6fi06JLd8r8%2Fjm201394e Journal of Medicinal ChemistryDOI: 10.1021/jm201394e (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5643315 Fri, 27 Jan 2012 15:01:50 +0100 5643315 Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design http://www.medworm.com/index.php?rid=5643316&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2Faq7zTxtQjbY%2Fjm201376w Journal of Medicinal ChemistryDOI: 10.1021/jm201376w (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5643316 Fri, 27 Jan 2012 14:59:57 +0100 5643316 Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease http://www.medworm.com/index.php?rid=5643317&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FeHG7_MkYplY%2Fjm201310y Journal of Medicinal ChemistryDOI: 10.1021/jm201310y (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5643317 Fri, 27 Jan 2012 14:58:28 +0100 5643317 Molecular Determinants of AcrB-Mediated Bacterial Efflux Implications for Drug Discovery http://www.medworm.com/index.php?rid=5643318&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FSmvIDAwo5DI%2Fjm201275d Journal of Medicinal ChemistryDOI: 10.1021/jm201275d (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5643318 Fri, 27 Jan 2012 14:52:41 +0100 5643318 Toll-Like Receptor (TLR)-7 and -8 Modulatory Activities of Dimeric Imidazoquinolines http://www.medworm.com/index.php?rid=5643319&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FB2kPdfyy3g4%2Fjm2010207 Journal of Medicinal ChemistryDOI: 10.1021/jm2010207 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5643319 Fri, 27 Jan 2012 14:50:19 +0100 5643319 Exploring Activity Cliffs in Medicinal Chemistry http://www.medworm.com/index.php?rid=5643312&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FwqwFbgF1wNM%2Fjm201706b Journal of Medicinal ChemistryDOI: 10.1021/jm201706b (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5643312 Fri, 27 Jan 2012 05:57:47 +0100 5643312 New Tacrine–4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties http://www.medworm.com/index.php?rid=5643313&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FK7845HfmQc4%2Fjm201460y Journal of Medicinal ChemistryDOI: 10.1021/jm201460y (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5643313 Fri, 27 Jan 2012 05:56:54 +0100 5643313 Directed R-Group Combination Graph: A Methodology To Uncover Structure–Activity Relationship Patterns in a Series of Analogues http://www.medworm.com/index.php?rid=5643314&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FVQoflitoV54%2Fjm201362h Journal of Medicinal ChemistryDOI: 10.1021/jm201362h (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5643314 Fri, 27 Jan 2012 05:56:14 +0100 5643314 Design and Characterization of Optimized Adenosine A2A/A1 Receptor Antagonists for the Treatment of Parkinson's Disease http://www.medworm.com/index.php?rid=5634723&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2F_mwAA8JPWlI%2Fjm201640m Journal of Medicinal ChemistryDOI: 10.1021/jm201640m (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5634723 Thu, 26 Jan 2012 19:41:21 +0100 5634723 Synthesis and Structure–Activity Relationships of (Aryloxy)quinazoline Ureas as Novel, Potent, and Selective Vascular Endothelial Growth Factor Receptor-2 Inhibitors http://www.medworm.com/index.php?rid=5634724&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FUEzhvOBt61M%2Fjm2013453 Journal of Medicinal ChemistryDOI: 10.1021/jm2013453 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5634724 Wed, 25 Jan 2012 21:06:40 +0100 5634724 Structure–Activity Relationship Study of Opiorphin, a Human Dual Ectopeptidase Inhibitor with Antinociceptive Properties http://www.medworm.com/index.php?rid=5634725&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FyWJqdJKNOCE%2Fjm2012112 Journal of Medicinal ChemistryDOI: 10.1021/jm2012112 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5634725 Wed, 25 Jan 2012 20:27:00 +0100 5634725 A New Strategy for the Development of Highly Potent and Selective Plasmin Inhibitors http://www.medworm.com/index.php?rid=5634726&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FS8X_r1oMvgA%2Fjm2011996 Journal of Medicinal ChemistryDOI: 10.1021/jm2011996 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5634726 Wed, 25 Jan 2012 20:26:30 +0100 5634726 The Bivalent Ligand Approach Leads to Highly Potent and Selective Acylguanidine-Type Histamine H2 Receptor Agonists http://www.medworm.com/index.php?rid=5634727&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FJ1ACHSRBHbw%2Fjm201128q Journal of Medicinal ChemistryDOI: 10.1021/jm201128q (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5634727 Wed, 25 Jan 2012 18:36:55 +0100 5634727 Linker-Based Hemisuccinate Derivatives of Artemisinin: Synthesis and Antimalarial Assessment against Multidrug-Resistant Plasmodium yoelii nigeriensis in Mice http://www.medworm.com/index.php?rid=5634728&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FX3xDFbJQO6s%2Fjm2010699 Journal of Medicinal ChemistryDOI: 10.1021/jm2010699 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5634728 Wed, 25 Jan 2012 18:35:53 +0100 5634728 Structural Basis of Selective Inhibition of Human Tankyrases http://www.medworm.com/index.php?rid=5634729&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FRUJm7kqEePQ%2Fjm201510p Journal of Medicinal ChemistryDOI: 10.1021/jm201510p (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5634729 Wed, 25 Jan 2012 14:49:34 +0100 5634729 Antimalarial Activity of 9a-N Substituted 15-Membered Azalides with Improved in Vitro and in Vivo Activity over Azithromycin http://www.medworm.com/index.php?rid=5634730&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2F4wPY572wexY%2Fjm201615t Journal of Medicinal ChemistryDOI: 10.1021/jm201615t (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5634730 Wed, 25 Jan 2012 12:35:31 +0100 5634730 Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction http://www.medworm.com/index.php?rid=5634731&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FrEnMbetKrz4%2Fjm201125d Journal of Medicinal ChemistryDOI: 10.1021/jm201125d (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5634731 Tue, 24 Jan 2012 16:43:31 +0100 5634731 Design, Synthesis, and Biological Evaluation of New Diaminoquinazolines as β-Catenin/Tcf4 Pathway Inhibitors http://www.medworm.com/index.php?rid=5634732&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FfFyhAset47E%2Fjm201494a Journal of Medicinal ChemistryDOI: 10.1021/jm201494a (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5634732 Tue, 24 Jan 2012 16:36:53 +0100 5634732 Drug-to-Genome-to-Drug, Step 2: Reversing Selectivity in a Series of Antiplasmodial Compounds http://www.medworm.com/index.php?rid=5624198&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2Fb8qB7MGiuBI%2Fjm201422e Journal of Medicinal ChemistryDOI: 10.1021/jm201422e (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5624198 Tue, 24 Jan 2012 12:56:21 +0100 5624198 Discovery of a Novel Class of Potent and Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists http://www.medworm.com/index.php?rid=5624199&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FdeCZQ03PsPk%2Fjm201533b Journal of Medicinal ChemistryDOI: 10.1021/jm201533b (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5624199 Tue, 24 Jan 2012 12:54:52 +0100 5624199 Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus http://www.medworm.com/index.php?rid=5624200&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FLfCREc0FpiE%2Fjm2014887 Journal of Medicinal ChemistryDOI: 10.1021/jm2014887 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5624200 Tue, 24 Jan 2012 12:54:02 +0100 5624200 Binding Evaluation of Fragment-Based Scaffolds for Probing Allosteric Enzymes http://www.medworm.com/index.php?rid=5624201&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2F-pB_AIhroec%2Fjm201439b Journal of Medicinal ChemistryDOI: 10.1021/jm201439b (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals 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journals http://www.medworm.com/rss/comments.php?id=5591915 Fri, 13 Jan 2012 19:20:17 +0100 5591915 Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas aeruginosa Thymidylate Kinase: From Hit to Lead Generation http://www.medworm.com/index.php?rid=5591916&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FKXzLy6EAqTM%2Fjm201349f Journal of Medicinal ChemistryDOI: 10.1021/jm201349f (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5591916 Fri, 13 Jan 2012 16:54:39 +0100 5591916 Oxadiazoles in Medicinal Chemistry http://www.medworm.com/index.php?rid=5591917&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2Fmk0YmlsOAmo%2Fjm2013248 Journal of Medicinal ChemistryDOI: 10.1021/jm2013248 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals 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2012 18:02:01 +0100 5591925 Novel 1,3-Dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as Potent and Selective A2B Adenosine Receptor Antagonists http://www.medworm.com/index.php?rid=5591930&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2F_AcdrTDs3Bw%2Fjm201292w Journal of Medicinal ChemistryDOI: 10.1021/jm201292w (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5591930 Wed, 11 Jan 2012 16:17:50 +0100 5591930 Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections http://www.medworm.com/index.php?rid=5591931&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FPq5_7KxQLC0%2Fjm2014748 Journal of Medicinal ChemistryDOI: 10.1021/jm2014748 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5591931 Wed, 11 Jan 2012 13:29:09 +0100 5591931 Synthesis and Evaluation of 18F-Labeled Styryltriazole and Resveratrol Derivatives for β-Amyloid Plaque Imaging http://www.medworm.com/index.php?rid=5591926&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FsSwyMZGiCGo%2Fjm201400q Journal of Medicinal ChemistryDOI: 10.1021/jm201400q (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5591926 Wed, 11 Jan 2012 05:04:54 +0100 5591926 Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery http://www.medworm.com/index.php?rid=5591927&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FYNyI6SlfFy4%2Fjm201320w Journal of Medicinal ChemistryDOI: 10.1021/jm201320w (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5591927 Wed, 11 Jan 2012 05:04:04 +0100 5591927 Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides http://www.medworm.com/index.php?rid=5591928&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2F1UjoQNjpUUw%2Fjm201283q Journal of Medicinal ChemistryDOI: 10.1021/jm201283q (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5591928 Wed, 11 Jan 2012 05:03:09 +0100 5591928 Privileged Scaffolds or Promiscuous Binders: A Comparative Study on Rhodanines and Related Heterocycles in Medicinal Chemistry http://www.medworm.com/index.php?rid=5591929&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FBOFodL72KLY%2Fjm201243p Journal of Medicinal ChemistryDOI: 10.1021/jm201243p (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals 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5567917 Antiandrogenic, Maspin Induction, and Antiprostate Cancer Activities of Tanshinone IIA and Its Novel Derivatives with Modification in Ring A http://www.medworm.com/index.php?rid=5567918&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FS9XmlFPbH6k%2Fjm2015292 Journal of Medicinal ChemistryDOI: 10.1021/jm2015292 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5567918 Fri, 06 Jan 2012 12:54:10 +0100 5567918 Synthesis and Biological Profile of the pan-Vascular Endothelial Growth Factor Receptor/Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor-Like Homology Domains 2 (VEGF-R/TIE-2) Inhibitor 11-(2-Methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): A Novel Oncology Therapeutic Agent 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journals http://www.medworm.com/rss/comments.php?id=5567929 Wed, 04 Jan 2012 14:10:25 +0100 5567929 7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes http://www.medworm.com/index.php?rid=5567930&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2F5oI7jPNmzUc%2Fjm201286z Journal of Medicinal ChemistryDOI: 10.1021/jm201286z (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5567930 Tue, 03 Jan 2012 16:01:16 +0100 5567930 (1S, 3S)-3-Amino-4-difluoromethylenyl-1-cyclopentanoic Acid (CPP-115), a Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Cocaine Addiction http://www.medworm.com/index.php?rid=5556567&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FkIX9QhzJfiE%2Fjm201231w Journal of Medicinal ChemistryDOI: 10.1021/jm201231w (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5556567 Fri, 30 Dec 2011 19:46:41 +0100 5556567 Nonquaternary Reactivators for Organophosphate-Inhibited Cholinesterases http://www.medworm.com/index.php?rid=5556568&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2F4DW50ItfPIg%2Fjm201364d Journal of Medicinal ChemistryDOI: 10.1021/jm201364d (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5556568 Thu, 29 Dec 2011 21:02:08 +0100 5556568 Design, Synthesis, and Biological Evaluation of Potent Quinoline and Pyrroloquinoline Ammosamide Analogues as Inhibitors of Quinone Reductase 2 http://www.medworm.com/index.php?rid=5556569&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FA8OXLpfzrcw%2Fjm201251c Journal of Medicinal ChemistryDOI: 10.1021/jm201251c (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5556569 Thu, 29 Dec 2011 20:59:57 +0100 5556569 Discovery of Kinase Spectrum Selective Macrocycle (16E)-14-Methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a Potent Inhibitor of Cyclin Dependent Kinases (CDKs), Janus Kinase 2 (JAK2), and Fms-like Tyrosine Kinase-3 (FLT3) for the Treatment of Cancer http://www.medworm.com/index.php?rid=5556570&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FJtSaXJ1vxoo%2Fjm201112g Journal of Medicinal ChemistryDOI: 10.1021/jm201112g (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5556570 Thu, 29 Dec 2011 20:59:36 +0100 5556570 Strategies to Mitigate the Bioactivation of 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Chemistry journals http://www.medworm.com/rss/comments.php?id=5556572 Thu, 29 Dec 2011 16:26:25 +0100 5556572 Structure–Activity Relationships of Truncated C2- or C8-Substituted Adenosine Derivatives as Dual Acting A2A and A3 Adenosine Receptor Ligands http://www.medworm.com/index.php?rid=5549325&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FiVl7lWIJPNo%2Fjm201229j Journal of Medicinal ChemistryDOI: 10.1021/jm201229j (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5549325 Wed, 28 Dec 2011 18:56:40 +0100 5549325 Niphatenones, Glycerol Ethers from the Sponge Niphates digitalis Block Androgen Receptor Transcriptional Activity in Prostate Cancer Cells: Structure Elucidation, Synthesis, and Biological Activity 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22 Dec 2011 11:57:55 +0100 5532342 Synthesis and Evaluation of 1,5-Disubstituted Tetrazoles as Rigid Analogues of Combretastatin A-4 with Potent Antiproliferative and Antitumor Activity http://www.medworm.com/index.php?rid=5532344&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FQyJOomkYVl8%2Fjm2013979 Journal of Medicinal ChemistryDOI: 10.1021/jm2013979 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5532344 Wed, 21 Dec 2011 15:55:33 +0100 5532344 Optimization of 5-Pyridazin-3-one Phenoxypropylamines as Potent, Selective Histamine H3 Receptor Antagonists with Potent Cognition Enhancing Activity http://www.medworm.com/index.php?rid=5532345&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2F5vx4vkoSVyA%2Fjm201295j Journal of Medicinal ChemistryDOI: 10.1021/jm201295j (Source: Journal of Medicinal Chemistry) Journal of 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ChemistryDOI: 10.1021/jm2012563 (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5532348 Tue, 20 Dec 2011 14:55:44 +0100 5532348 Studies toward Novel Peptidomimetic Inhibitors of Thioredoxin–Thioredoxin Reductase System http://www.medworm.com/index.php?rid=5532349&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FzpwFop3YvoQ%2Fjm201359d Journal of Medicinal ChemistryDOI: 10.1021/jm201359d (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5532349 Tue, 20 Dec 2011 13:59:28 +0100 5532349 Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO2) as Antimycobacterial Agents http://www.medworm.com/index.php?rid=5520046&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FzOE5GRSzGFQ%2Fjm201023g Journal of Medicinal ChemistryDOI: 10.1021/jm201023g (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5520046 Mon, 19 Dec 2011 15:11:04 +0100 5520046 Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies http://www.medworm.com/index.php?rid=5520047&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2Fvnkp7QOCQgg%2Fjm201263k Journal of Medicinal ChemistryDOI: 10.1021/jm201263k (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5520047 Mon, 19 Dec 2011 12:44:15 +0100 5520047 Myelin Imaging Compound (MIC) Enhanced Magnetic Resonance Imaging of Myelination http://www.medworm.com/index.php?rid=5511562&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2Fjer15acW3No%2Fjm201010e Journal of Medicinal ChemistryDOI: 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Piperazine-2,3-dicarboxylic Acid Derivatives as Dual Antagonists of NMDA and GluK1-Containing Kainate Receptors http://www.medworm.com/index.php?rid=5511568&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FHIi51f3DVRk%2Fjm201230z Journal of Medicinal ChemistryDOI: 10.1021/jm201230z (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5511568 Wed, 14 Dec 2011 15:01:00 +0100 5511568 Molecular Basis of Structure–Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes http://www.medworm.com/index.php?rid=5500449&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2Fnxjeh67cPuI%2Fjm201140v Journal of Medicinal ChemistryDOI: 10.1021/jm201140v (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5500449 Tue, 13 Dec 2011 20:52:05 +0100 5500449 A New Generation of Radiofluorinated Pyrimidine-2,4,6-triones as MMP-Targeted Radiotracers for Positron Emission Tomography http://www.medworm.com/index.php?rid=5500450&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2FshKrHF3nW8w%2Fjm201142w Journal of Medicinal ChemistryDOI: 10.1021/jm201142w (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals http://www.medworm.com/rss/comments.php?id=5500450 Tue, 13 Dec 2011 15:21:47 +0100 5500450 Evaluation of Molecular Modeling of Agonist Binding in Light of the Crystallographic Structure of an Agonist-Bound A2A Adenosine Receptor http://www.medworm.com/index.php?rid=5500451&cid=s_32526_59_f&fid=32526&url=http%3A%2F%2Ffeedproxy.google.com%2F%7Er%2Facs%2Fjmcmar%2F%7E3%2Fli70nhl1H0I%2Fjm201461q Journal of Medicinal ChemistryDOI: 10.1021/jm201461q (Source: Journal of Medicinal Chemistry) Journal of Medicinal Chemistry journals 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