MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Neuro-Oncology' source. Wed, 17 Mar 2010 13:52:21 +0100 http://www.medworm.com/index.php?rid=3360339&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F248j1021v0072633%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s11060-010-0155-3Authors Watcharin Loilome, Johns Hopkins University Department of Neurosurgery, School of Medicine Baltimore MD 21231 USAAvadhut D. Joshi, Johns Hopkins University Department of Neurosurgery, School of Medicine Baltimore MD 21231 USAColette M. J. ap Rhys, Johns Hopkins University Department of Neurosurgery, School of Medicine Baltimore MD 21231 USASara Piccirillo, Università degli Studi Bicocca-Millan Milan 20126 ItalyAngelo L. Vescovi, Università degli Studi Bicocca-Millan Milan 20126 ItalyGary L. Gallia, Johns Hopkins University Department of Neurosurgery, School of Medicine Baltimore MD 21231 USAGregory J. Riggins, Johns Hopkins University Department of Neurosurgery, School of Medicine Baltimore MD 21231 USA ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3360339 Thu, 11 Mar 2010 02:43:21 +0100 3360339 http://www.medworm.com/index.php?rid=3360340&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh309u6591128643j%2F Abstract  To report long-term results for children with low-grade hypothalamic/chiasmatic gliomas treated on a phase II chemotherapy protocol. Between 1984 and 1992, 33 children with hypothalamic/chiasmatic LGGs received TPDCV chemotherapy on a phase II prospective trial. Median age was 3.0 years (range 0.3–16.2). Twelve patients (36%) underwent STRs, 14 (42%) biopsy only, and seven (21%) no surgery. Twenty patients (61%) had pathologic JPAs, nine (27%) grade II gliomas, and four (12%) no surgical sampling. Median f/u for surviving patients was 15.2 years (range 5.3–20.7); 20 of the 23 surviving patients had 14 or more years of follow-up. Fifteen-year PFS and OS were 23.4 and 71.2%, respectively. Twenty-five patients progressed, of whom 13 are NED, two are AWD,... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3360340 Thu, 11 Mar 2010 02:43:20 +0100 3360340 http://www.medworm.com/index.php?rid=3355554&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj71x868380u761h6%2F Abstract  Complete surgical resection beyond tumor margins cannot be achieved in glioblastoma multiforme (GBM) because of infiltrative nature. In several cancers, neoadjuvant treatment has been implemented to reduce the risk of tumor cell spreading during resection. In GBM, the objective of a neoadjuvant approach is reduction of tumor cells within the main tumor mass and beyond in the infiltration zone. Such an approach can only be performed if elevated intracranial pressure can be medically controlled. In a previous study with recurrent gliomas, we showed that local intratumoral injection of radiolabeled DOTAGA–substance P substantially inhibited further growth and led to radionecrotic transformation of the tumor (CCR 2006). We have now examined this modality as neoadjuv... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3355554 Wed, 10 Mar 2010 16:00:43 +0100 3355554 http://www.medworm.com/index.php?rid=3355555&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F23287nwp11318863%2F This study evaluated the role of CDC25 phosphatases in human glioma proliferation. Upregulation of CDC25A was observed in human glioma specimens and human glioma cell lines. Comparison of expression levels of CDC25A and CDC25B messenger ribonucleic acid (RNA) to Ki-67 labeling index in glioma tissues found that Ki-67 labeling index was significantly correlated with the expression of CDC25A, but not with that of CDC25B. Depletion of CDC25A by small interfering RNA and inhibition of CDC25 suppressed cell proliferation and induced apoptosis in glioma cell lines, indicating that CDC25A is a potential target for the development of new therapy for glioma. Content Type Journal ArticleCategory Laboratory Investigation - Human/Animal TissueDOI 10.1007/s11060-010-0147-3Authors Yoji Yamas... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3355555 Wed, 10 Mar 2010 16:00:42 +0100 3355555 http://www.medworm.com/index.php?rid=3355557&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9m8138nx2r532626%2F Abstract  Gliomas are common malignant tumors of the human neural system, and Wnt signaling activation is closely related to glioma malignancy. Human Pygopus 2 (Pygo2) was recently discovered to be a component of the Wnt signaling pathway, which is required for β-catenin/Tcf-dependent transcription. However, the role of Pygo2 in glioblastoma cell growth and survival remains uncertain. In the present study, Pygo2 expression was evaluated in 80 glioma tissue samples. Results demonstrated that tumor grade exhibited a positive correlation with overexpression of Pygo2. In addition, small hairpin RNA (shRNA) was used to specifically knockdown Pygo2 expression in human glioblastoma U251 cell lines. Results showed that inhibition of Pygo2 expression resulted in inhibited cell prol... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3355557 Wed, 10 Mar 2010 16:00:41 +0100 3355557 http://www.medworm.com/index.php?rid=3355556&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr70t01m0h34r2477%2F This study was conducted to determine the side effects and maximum tolerated dose (MTD) of bortezomib in patients with recurrent malignant glioma. Separate dose escalations were conducted in patients taking or not taking enzyme-inducing anti-seizure drugs (+/−EIASD). The starting dose in both groups was 0.9 mg/m2 intravenously twice weekly for the first three of each 4 week cycle. Imaging assessment of response was carried out and Plasma 20S proteasome activity inhibition and imaging was conducted to monitor efficacy. The 66 patients enrolled had a median age of 51 years, median KPS of 90%, and 77% had glioblastoma multiforme. The MTD in the −EIASD group was 1.70 mg/m2 based on grade 3 thrombocytopenia, sensory neuropathy and fatigue. In the +EIASD group escala... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3355556 Wed, 10 Mar 2010 16:00:41 +0100 3355556 http://www.medworm.com/index.php?rid=3355558&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1647g2842v70k46q%2F Abstract  Ten year survival rates for patients with craniopharyngioma vary from 24 to 100%. A review of the database of all children diagnosed with craniopharyngioma in British Columbia (BC) revealed that several patients died >10 years after diagnosis. This retrospective study investigates the causes and timing of deaths and reports the overall survival in this population based group of patients. A chart review was conducted on all patients aged <17 years, diagnosed in BC with craniopharyngioma between 1967 and 2003. Imaging studies were reviewed by a neuroradiologist. All deaths in the province are reported to a central agency, which allowed identification of patients who died after being lost to clinical follow up. Forty-one patients were identified with ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3355558 Wed, 10 Mar 2010 16:00:40 +0100 3355558 http://www.medworm.com/index.php?rid=3328307&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0j9771j3x7011540%2F In this study, we assessed the factors affecting the prognosis of AO patients. Seventy AO patients were recruited from 2001 to 2006 in Shanghai Huashan Hospital of Fudan University; all were treated surgically. Kaplan–Meier survival analysis and Cox regression analysis were used to analyze the prognostic effects of 14 different factors, which were selected from clinical, radiological, pathological, and treatment variables. The results showed that chemotherapy, age, primary or secondary tumors, preoperative Karnofsky Performance Scale (KPS) scores, the presence of epilepsy at initial presentation, radiological contrast infusion, and neurological parameters all correlated with the prognosis of the patients. Furthermore, Cox multivariate analysis also showed that the age (P <&... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3328307 Tue, 02 Mar 2010 10:03:48 +0100 3328307 http://www.medworm.com/index.php?rid=3323725&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw8r73537012471h8%2F Abstracts  Intracranial tuberculoma generally presents as either solitary or multiple lesions in the brain parenchyma. These are characterized by a ring-enhancing area on either computerized tomography scans or magnetic resonance images. A 66 year-old female with a history of breast carcinoma at 41 years, treated with radical mastectomy and radio and chemotherapy, and rheumatoid arthritis, treated in the last 10 years, presented two months ago with occipital headache, nausea, cerebellar syndrome, alterations of speech, and memory loss. The TC scan showed occipital enhancement by contrast and surrounded by oedema, suggesting metastasis. Histology showed a benign meningioma with many multinuclear giant cells, granulomas, and central caseating necrosis.... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3323725 Mon, 01 Mar 2010 18:09:25 +0100 3323725 http://www.medworm.com/index.php?rid=3315450&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn3813616680540q7%2F Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-010-0148-2Authors Domenico Ribatti, University of Bari Medical School Department of Human Anatomy and Histology Piazza G. Cesare 11, Policlinico 70124 Bari ItalyBeatrice Nico, University of Bari Medical School Department of Human Anatomy and Histology Piazza G. Cesare 11, Policlinico 70124 Bari ItalyAnca Maria Cimpean, “Victor Babes” University of Medicine and Pharmacy Department of Histology and Cytology Pta Eftimie Murgu 2 300041 Timisoara RomaniaMarius Raica, “Victor Babes” University of Medicine and Pharmacy Department of Histology and Cytology Pta Eftimie Murgu 2 300041 Timisoara Romania Journal Journal of Neuro-OncologyOnline ISSN 1573-7373Print ISSN 0167-594X (Source: Journal of Neuro-Oncology) Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3315450 Fri, 26 Feb 2010 09:42:58 +0100 3315450 http://www.medworm.com/index.php?rid=3315451&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6217503785881475%2F Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-010-0149-1Authors Liverana Lauretti, Catholic University School of Medicine Department of Neurosurgery Largo Agostino Gemelli, 8 00168 Rome ItalyNicola Montano, Catholic University School of Medicine Department of Neurosurgery Largo Agostino Gemelli, 8 00168 Rome ItalyGiovanna Paternoster, Catholic University School of Medicine Department of Neurosurgery Largo Agostino Gemelli, 8 00168 Rome ItalyEduardo Fernandez, Catholic University School of Medicine Department of Neurosurgery Largo Agostino Gemelli, 8 00168 Rome ItalyMariangela Novello, Catholic University School of Medicine Department of Pathology Rome ItalyLibero Lauriola, Catholic University School of Medicine Department of Pathology Rome ItalyRoberto Pallini, Cat... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3315451 Fri, 26 Feb 2010 09:42:57 +0100 3315451 http://www.medworm.com/index.php?rid=3315452&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm306200j87q0217m%2F Abstract   Radiotherapy (RT) is the standard treatment for high-grade gliomas. However, toxicity may develop during RT, such as brain edema or worsening of neurological symptoms. Surprisingly, no dedicated study had focused on steroid requirements during RT in adult patients with malignant gliomas. We evaluated prospectively all patients with malignant gliomas treated by RT in a single center from July 2006 to May 2009. Age, sex, initial Karnofsky performance status (KPS), tumor localization and histology, type of surgical resection, clinical target volume, total dose and duration of RT, concomitant treatment with temozolomide, and steroid dosage during RT and at 1 and 3 months after RT were recorded in all patients. Most of the 80 patients (70%) were already taking st... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3315452 Fri, 26 Feb 2010 06:45:53 +0100 3315452 http://www.medworm.com/index.php?rid=3308097&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv5w2014028860173%2F Abstract  Brain tumor patients undergo various combinations therapies, leading to very complex and confusing imaging appearances on follow up MR imaging and hence, differentiating recurrent or progressing tumors from treatment induced necrosis or effects has always been a challenge in neuro-oncologic imaging. This particular topic has become more relevant these days because of the advent of newer anti-angiogenic and anti-neoplastic chemotherapeutic agents as well as use of salvage radiation therapy. Various clinically available functional imaging modalities can provide additional physiologic and metabolic information about the tumors which could be useful in identifying viable tumor from treatment induced necrosis and hence, can guide treatment planning. In this review we w... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3308097 Wed, 24 Feb 2010 06:50:31 +0100 3308097 http://www.medworm.com/index.php?rid=3295540&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw3r725263438vj87%2F Abstract  Hemangioblastomas frequently develop in patients with von Hippel-Lindau (VHL) disease, an autosomal dominant genetic disorder. The tumors are characterized by a dense network of blood capillaries, often in association with cysts. Although activation of receptor tyrosine kinase (RTK) signaling, including epidermal growth factor receptor (EGFR) has been implicated in the development of malignant brain tumors such as high-grade gliomas, little is known about the role of RTK signaling in hemangioblastomas. To address this issue, we examined hemangioblastoma tumor specimens using receptor tyrosine kinase (RTK) activation profiling and immunohistochemistry. Six human hemangioblastomas were analyzed with a phospho-RTK antibody array, revealing EGFR phosphorylation in all... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3295540 Sun, 21 Feb 2010 06:55:37 +0100 3295540 http://www.medworm.com/index.php?rid=3295541&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr338116449867478%2F The objective of this study was to evaluate, in a series of 43 pediatric high-grade gliomas (21 anaplastic astrocytoma WHO grade III and 22 glioblastoma WHO grade IV), the prognostic value of histological grading and expression of p53 and YKL-40. Moreover, mutational screening for TP53 and IDH1 was performed in 27 of 43 cases. The prognostic stratification for histological grading showed no difference in overall (OS) and progression-free survival (PFS) between glioblastomas and anaplastic astrocytomas. Overexpression of YKL40 was detected in 25 of 43 (58%) cases, but YKL-40 expression was not prognostic in terms of OS and PFS. p53 protein expression was observed in 13 of 43 (31%) cases but was not prognostic. TP53 mutations were detected in five of 27 (18%) cases (four glioblastomas a... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3295541 Sat, 20 Feb 2010 06:52:48 +0100 3295541 http://www.medworm.com/index.php?rid=3280944&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F91703975662850w0%2F Abstract  Invasion is a hallmark of malignant gliomas and is the main reason for therapeutic failure and recurrence of the tumor. CXCR4 is a key chemokine receptor implicated in glioma cell migration whose expression is regulated by hypoxia. Here, we report that hepatocyte growth factor (HGF) upregulated CXCR4 protein expression in glioma cells. HGF pre-treatment increased migration of U87MG and LN229 glioma cells towards the CXCR4 ligand, stromal cell-derived factor-1α (SDF-1α). AMD3100, a CXCR4 inhibitor, inhibited the increased migration of HGF pre-treated LN229 glioma cells towards SDF-1α. Following exposure to HGF and hypoxia, both cell lines showed nuclear translocation of NF-κB (p65). The HGF- and hypoxia-induced nuclear translocation of NF-κB (p65) involved pho... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3280944 Tue, 16 Feb 2010 06:41:53 +0100 3280944 http://www.medworm.com/index.php?rid=3270394&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4j4h71v1237202p0%2F Abstract  After withdrawal of bevacizumab in patients with recurrent high-grade glioma, we have observed a rapid tumour re-growth or “rebound” radiographic phenomenon with accelerated clinical decline. We retrospectively reviewed 11 patients treated at the Henry Ford Hermelin Brain Tumor Center with recurrent high-grade glioma who demonstrated a rebound progression pattern after the discontinuation of bevacizumab. The original tumour area-of-enhancement increased by a mean of 158%, when compared to the rebound magnetic resonance imaging. After rebound, no patients (0/8) showed a response to next-line treatments that did not include bevacizumab. The median survival of those re-treated with bevacizumab was 149 and 32 days for those who received other regimens. Abrupt... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3270394 Fri, 12 Feb 2010 07:09:58 +0100 3270394 http://www.medworm.com/index.php?rid=3270393&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc34647v88t66m727%2F Abstract  After successfully using cisplatin (30 mg/m2/day) and etoposide (150 mg/m2/day) in ten three-day courses for progressive low-grade gliomas, a subsequent protocol reduced the daily doses of cisplatin (to 25 mg) and etoposide (to 100 mg), with the objective of achieving the same response and three-year PFS rates with lower neurotoxicity and myelotoxicity. We treated 37 patients (median age 6 years); 23 had optochiasmatic tumours and nine were metastatic cases. Diagnoses were clinical in 13 cases and histological in 24, and comprised: pilocytic astrocytoma (17), ganglioglioma (3), pilomyxoid astrocytoma (2), and fibrillary astrocytoma (2). Treatment was prompted by radiological evidence of progression and/or clinical deterioration a median 18 ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3270393 Fri, 12 Feb 2010 07:09:58 +0100 3270393 http://www.medworm.com/index.php?rid=3270395&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb611j28201526466%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s11060-010-0132-xAuthors Makoto Sasaki, Juntendo University School of Medicine Division of Hematology, Department of Internal Medicine 2-1-1 Hongo, Bunkyo-ku Tokyo 113-8421 JapanKoichi Sugimoto, Juntendo University School of Medicine Division of Hematology, Department of Internal Medicine 2-1-1 Hongo, Bunkyo-ku Tokyo 113-8421 JapanAzuchi Masuda, Juntendo University School of Medicine Division of Hematology, Department of Internal Medicine 2-1-1 Hongo, Bunkyo-ku Tokyo 113-8421 JapanYutaka Tsukune, Juntendo University School of Medicine Division of Hematology, Department of Internal Medicine 2-1-1 Hongo, Bunkyo-ku Tokyo 113-8421 JapanYuriko Yahata, Juntendo University School of Medicine Division of Hematology, Departmen... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3270395 Fri, 12 Feb 2010 07:09:57 +0100 3270395 http://www.medworm.com/index.php?rid=3270396&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3167132215714400%2F The objective of this study was to more fully describe selected olfactory tumors using a large population-based cancer incidence database. The Surveillance, Epidemiology and End Results (SEER) 9 registries limited-use data were reviewed from 1973 to 2006 for selected nasal cavity (C30.0) and accessory sinus (C31.0–31.9) tumors. Frequencies, incidence rates, and relative survival rates were estimated using SEER*Stat, v6.5.2. The majority of cases were squamous cell carcinoma (SCC), while the incidence of ON was greater than CND. For ON, the incidence was highest in the 60–79 year age group, while for SCC, the incidence was highest in the 80+ year age group. For CND, the incidence leveled off in the oldest age groups. Survival rates were highest for ON (>70% alive at 5... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3270396 Fri, 12 Feb 2010 07:09:56 +0100 3270396 http://www.medworm.com/index.php?rid=3270397&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff8r250515713854m%2F We present the case of a 55-year-old female who developed HSE type 1 during brain irradiation and antioedematous dexamethasone treatment for leptomeningeal metastasized breast tumor with epileptic seizures. During the radiotherapy (RT), after a total of 32 Gray administrated in 16 fractions, our patient developed cognitive impairment and partial epileptic status without fever. Two days later the patient’s clinical conditions had deteriorated and high fever manifested. A diagnosis of HSE type 1 was made by a positive cerebrospinal fluid polymerase chain reaction. Antiviral therapy with high doses of acyclovir was practiced for four weeks but the comatose state persisted. The patient died 59 days after the last RT fraction. The temporal relationship of RT to the occurrence ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3270397 Thu, 11 Feb 2010 11:49:30 +0100 3270397 http://www.medworm.com/index.php?rid=3263842&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc076hg052u702210%2F This study reports the case of a 75-year-old woman with intermittent speech disturbance, headache, and general malaise. Brain magnetic resonance imaging showed a double lesion located in the third ventricle and temporal horn of the lateral ventricle. We completely removed the lesion in the third ventricle, adhering to the septum pellucidum. The histopathological diagnosis was Burkitt lymphoma, which was confirmed to be primary in postoperative investigation. To our knowledge, this is the first case of primary Burkitt lymphoma involving cerebral ventricles. Finally, we reviewed the characteristics of primary central nervous system Burkitt lymphoma. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-010-0122-zAuthors Ye Gu, Zhongshan Hospital, Fudan University Depar... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3263842 Tue, 09 Feb 2010 17:45:31 +0100 3263842 http://www.medworm.com/index.php?rid=3263841&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl6600118227kj564%2F Abstract  Bone involvement is a common finding in many types of lymphoma (Clin Oncol 9(3): 195–196, 1997). However, cranial vault affliction has been regarded as an exceedingly rare presentation, particularly in the case of primary lymphoma (J Neurosurg 108(5): 1018–1020, 2008). Our objective is to describe a series of five immunocompetent patients with histologically confirmed cranial vault lymphoma (CVL), and to conduct a systematic review of the current literature. Our review points out identical imaging patterns in most of the lesions for all reported CVL cases, despite their different histological subtypes. This typical pattern can be seen on computed tomography (CT) scans and magnetic resonance imaging (MRI) as an expansive tumor that affects all three compartments ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3263841 Tue, 09 Feb 2010 17:45:31 +0100 3263841 http://www.medworm.com/index.php?rid=3263840&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv266504k82151139%2F We report on a patient who developed MG after thymomectomy for a malignant thymoma. After MG remission, NMT and Morvan’s syndrome occurred, which heralded a mediastinic recurrence, as demonstrated only by autopsy findings. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-010-0130-zAuthors C. Briani, University of Padova Departments of Neurosciences Via Giustiniani, 5 35128 Padova ItalyA. Cagnin, University of Padova Departments of Neurosciences Via Giustiniani, 5 35128 Padova ItalyS. Blandamura, University of Padua Medical Diagnostic Sciences and Special Therapies Padova ItalyG. Altavilla, University of Padua Medical Diagnostic Sciences and Special Therapies Padova Italy Journal Journal of Neuro-OncologyOnline ISSN 1573-7373Print ISSN 0167-594X (Source: Jou... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3263840 Tue, 09 Feb 2010 17:45:31 +0100 3263840 http://www.medworm.com/index.php?rid=3263844&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbup3772252413r07%2F Abstract  Despite resection, radiochemotherapy, and maintenance temozolomide chemotherapy (TMZm), the prognosis of patients with glioblastoma multiforme (GBM) remains poor. We integrated immunotherapy in the primary standard treatment for eight pilot adult patients (median age 50 years) with GBM, to assess clinical and immunological feasibility and toxicity in preparation of a phase I/II protocol HGG-2006. After maximum, safe resection, leukapheresis was performed before radiochemotherapy, and four weekly vaccinations with autologous GBM lysate-loaded monocyte-derived dendritic cells were given after radiochemotherapy. Boost vaccines with lysates were given during TMZm. During the course of vaccination, immunophenotyping showed a relative increase in CD8+CD25+ cells in... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3263844 Tue, 09 Feb 2010 17:45:30 +0100 3263844 http://www.medworm.com/index.php?rid=3263843&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu4327v3444602671%2F Abstract  To determine the safety and tolerability of IV and oral levetiracetam monotherapy for seizures in brain tumor patients following resection. Brain tumor patients undergoing neurosurgery with ≥1 seizure within the preceding month prior to surgery were enrolled to receive intravenous levetiracetam for a minimum of 48 h, transitioned to oral levetiracetam at the same dose, and followed for 1-month after discharge. Patients were assessed daily in the hospital, provided with a seizure diary, and supplied with 30 days of levetiracetam upon discharge. Study patients were telephoned weekly to assess their cognitive status and seizure frequency. Of the 17 patients enrolled, the baseline seizure types were tonic clonic, partial, and complex partial with secondary ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3263843 Tue, 09 Feb 2010 17:45:30 +0100 3263843 http://www.medworm.com/index.php?rid=3263845&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F35263p017146xn05%2F We describe the case of a patient who presented with symptoms of increased intracranial pressure and diffuse leptomeningeal enhancement in the brain and spinal cord on MRI. After a period of surveillance, intraparenchymal lesions developed in association with widespread diffuse infiltration. The diagnosis of gliomatosis cerebri with diffuse leptomeningeal gliomatosis was established in hindsight. Initial treatment consisted of six cycles of temozolomide chemotherapy. Following radiological progression, the patient received craniospinal radiotherapy. Four months later the patient’s symptoms had resolved and MRI demonstrated near complete response of leptomeningeal enhancement and intraparenchymal lesions. Six months after radiotherapy, the patient remains clinically well without rad... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3263845 Tue, 09 Feb 2010 17:45:29 +0100 3263845 http://www.medworm.com/index.php?rid=3263847&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F26kq3282500846w0%2F Abstract  Leptomeningeal metastases (LM) occur in 5–10% of patients with solid tumors and are associated with a dismal prognosis. We describe LM from lung adenocarcinoma harboring a mutation in the epidermal growth factor receptor (EGFR) gene that confers sensitivity to the EGFR tyrosine kinase inhibitors (EGFR-TKIs) erlotinib and gefitinib. The CSF concentration of EGFR-TKIs achieved by standard daily dosing may be insufficient for therapeutic effect. However, intermittent (pulsatile) high dose administration (1000–1500 mg/week) achieves a higher CSF concentration than standard dosing, and successfully controlled LM in this patient. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-010-0128-6Authors Jennifer L. Clarke, Memorial Sloan-Kettering... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3263847 Tue, 09 Feb 2010 17:45:27 +0100 3263847 http://www.medworm.com/index.php?rid=3263846&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj531347777568102%2F This study thus contributes further to elucidating the molecular mechanism of opening of the BTB by BK and provides a theoretical basis for clinical application of BK. Content Type Journal ArticleCategory Laboratory Investigation - Human/Animal TissueDOI 10.1007/s11060-010-0124-xAuthors Li-bo Liu, China Medical University Department of Neurobiology, College of Basic Medicine 110001 Shenyang Liaoning Province People’s Republic of ChinaYi-xue Xue, China Medical University Department of Neurobiology, College of Basic Medicine 110001 Shenyang Liaoning Province People’s Republic of ChinaYun-hui Liu, China Medical University Department of Neurosurgery, Shengjing Hospital 110004 Shenyang People’s Republic of China Journal Journal of Neuro-OncologyOnline ISSN 1573-7373Print ISSN... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3263846 Tue, 09 Feb 2010 17:45:27 +0100 3263846 http://www.medworm.com/index.php?rid=3255806&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F676w1p7x1243677x%2F We describe a patient with brainstem encephalitis who had elevated anti-Ri antibody levels and double-step neurological deterioration associated with different abnormal lesions on MRI. Immunosuppression with steroids and intravenous immune globulin combined with aggressive treatment of the tumor successfully led to the resolution of brainstem symptoms and MRI lesions. In patients with unusual signs and symptoms of paraneoplastic encephalitis mimicking multiple sclerosis, onconeural antibody studies are recommended. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-010-0135-7Authors Kin Tesseki, Nara Medical University Department of Neurology 840 Shijo-cho, Kashihara Nara 634-8522 JapanHiroshi Kataoka, Nara Medical University Department of Neurology 840 Shijo-cho, ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3255806 Mon, 08 Feb 2010 17:31:23 +0100 3255806 http://www.medworm.com/index.php?rid=3247892&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F911110r024408170%2F Abstract  In children under the age of 3, the most common solid tumours are brain tumors. Treatment for many of these patients includes surgery, chemotherapy and rarely radiation therapy. Many clinical trials have been performed in an attempt to establish the best treatment for these patients. Patients enrolled on clinical trials contribute to the establishment of the best therapy. We performed a national survey of all children less than the age of three with brain tumours and examined the contribution these patients made to clinical trials. A data bank was established using data collected from Canadian pediatric oncology centers on children less than age 3 diagnosed with brain tumours between 1990 and 2005. Data were collected on the use of adjunctive treatment after surge... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3247892 Fri, 05 Feb 2010 06:59:54 +0100 3247892 http://www.medworm.com/index.php?rid=3247893&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1517316356qt473r%2F Abstract  Histone deacetylase (HDAC) inhibitors represent a promising class of anti-cancer agents that are actively being evaluated in the context of clinical trials in solid tumors, including glioblastoma. What makes these agents particularly attractive is their capacity to enhance the activity of commonly used cytotoxics in cancer therapy, including both chemotherapy and ionizing radiation. As recent investigations suggest HDAC inhibitors may potentiate the cytotoxicity of topoisomerase inhibitors, which continue to be a commonly used class of agents in the treatment of glioblastoma, we performed preclinical studies to determine if this combination may be a promising strategy in glioblastoma. The effects of the HDAC inhibitor vorinostat and SN38, which is the active metab... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3247893 Fri, 05 Feb 2010 06:59:53 +0100 3247893 http://www.medworm.com/index.php?rid=3228477&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjr178842998668p3%2F Content Type Journal ArticleCategory Retraction NoteDOI 10.1007/s11060-010-0120-1Authors Sheng-hua Chu, NO. 3 People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Neurosurgery Shanghai 201900 ChinaYan-bin Ma, NO. 3 People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Neurosurgery Shanghai 201900 ChinaHong Zhang, NO. 3 People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Neurosurgery Shanghai 201900 ChinaDong-fu Feng, NO. 3 People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Neurosurgery Shanghai 201900 ChinaZhi-an Zhu, NO. 3 People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Depar... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3228477 Fri, 29 Jan 2010 17:59:13 +0100 3228477 http://www.medworm.com/index.php?rid=3205687&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F170j23w64321181u%2F This study was done to document the clinical and pathological features of ten patients with chordoid meningioma who submitted to surgery at the National Institute of Neurology and Neurosurgery in Mexico City. Clinical, histological and immunohistochemical features were examined. The age range was from 30 to 67 years old (mean, 34.2 years). Seven patients were female and three male. The duration of symptoms varied from 3.5 months to 5 years (mean, 14.1 months). No systemic symptoms were noted. The tumor was localized in eight cases in the supratentorial compartments. Histologically, the tumors were characterized by strands and cords of meningothelial cells arranged in a mucinous stroma. Two of the ten tumors showed metaplasic changes, and seven showed brain in... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3205687 Fri, 22 Jan 2010 10:10:42 +0100 3205687 http://www.medworm.com/index.php?rid=3205688&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh874t1837l56m674%2F In conclusion, MET SUVmax correlates with LAT1 expression in the tumor in newly diagnosed gliomas. MET transport may be increased by an increased number of microvessels combined with a higher density or activity of LAT1 in the tumor endothelial cells in high-grade gliomas. Use of MET-PET as a molecular target combined with anti-angiogenesis in glioma therapy should be addressed in future studies. Content Type Journal ArticleCategory Clinical Study - Patient StudyDOI 10.1007/s11060-010-0117-9Authors Shuichi Okubo, Kagawa University Department of Neurological Surgery, Faculty of Medicine 1750-1 Miki-cho, Kita-gun Kagawa 761-0793 JapanHai-Ning Zhen, Kagawa University Department of Neurological Surgery, Faculty of Medicine 1750-1 Miki-cho, Kita-gun Kagawa 761-0793 JapanNobuyuki Kawai, ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3205688 Thu, 21 Jan 2010 10:43:28 +0100 3205688 http://www.medworm.com/index.php?rid=3194911&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl275h19121266395%2F Abstract  Germinoma in the basal ganglia (BG) is notorious for its diagnostic difficulty. Clinical and radiological features of this disease are quite diverse, but have not been well characterized with respect to prognosis. We retrospectively reviewed the clinical course and treatment outcomes of 17 patients with a BG germinoma. The initial magnetic resonance imaging (MRI) features were classified. Clinical features and treatment outcomes were then analyzed with this classification scheme. A Type 1 lesion was defined as a subtle lesion with faint or no contrast enhancement (six patients). Type 2, 3, and 4 lesions were defined as contrast-enhancing lesions and were differentiated by the lesion size and the presence of subependymal seeding (11 patients). Type 1 lesions were d... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3194911 Wed, 20 Jan 2010 06:45:04 +0100 3194911 http://www.medworm.com/index.php?rid=3194912&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj453006u132h4853%2F Abstract  The purpose of this study is to determine the efficacy of Gamma Knife stereotactic radiosurgery (GK SRS) for intracranial hemangiopericytomas, and to investigate the optimal dose for successful tumor control without adverse effects. We evaluated 17 hemangiopericytomas of nine patients treated with GK SRS between 1999 and 2008. The mean tumor volume was 2.2 cm3 (range 0.2–9.9 cm3), and the mean and median marginal doses were 18.1 and 20 Gy (range 11–22 Gy), respectively, at the 50% isodose line. Mean clinical and radiological follow-up periods were 49 and 34 months, respectively. Successful tumor control was achieved in 14 of 17 lesions (82.4%) at time of last follow-up after GK SRS. Actuarial local tumor control rates at 1, 2, and 5&nbsp... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3194912 Tue, 19 Jan 2010 06:45:23 +0100 3194912 http://www.medworm.com/index.php?rid=3190397&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwq32j5h52h74x341%2F Abstract  In recent years, few studies have specifically focused on only histological features in choroid plexus tumors. We retrospectively reviewed the clinicopathologic and histological features in 37 patients with choroid plexus tumors and correlated these with glial fibrillary acidic protein (GFAP) expression and proliferation cell nuclear antigen (PCNA), p53, p21, and Rb labeling indexes, with special attention to tumor recurrence/regrowth. The study included 24 choroid plexus papillomas (CPPs), 4 atypical choroid plexus papillomas (ACPPs), and 9 choroid plexus carcinomas (CPCs). Patient age ranged from 15 to 70 years (mean 44 years). Most of the choroid plexus tumors were located in the IV ventricle. Recurrence was observed in 21 (52%) cases, 14 of which wer... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3190397 Fri, 15 Jan 2010 18:00:58 +0100 3190397 http://www.medworm.com/index.php?rid=3177037&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr1372618w1802573%2F Abstract  Glioblastoma multiforme (GBM) is a rapidly progressive disease of morbidity and mortality and is the most common form of primary brain cancer in adults. Lack of appropriate in vivo models has been a major roadblock to developing effective therapies for GBM. A new highly invasive in vivo GBM model is described that was derived from a spontaneous brain tumor (VM-M3) in the VM mouse strain. Highly invasive tumor cells could be identified histologically on the hemisphere contralateral to the hemisphere implanted with tumor cells or tissue. Tumor cells were highly expressive for the chemokine receptor CXCR4 and the proliferation marker Ki-67 and could be identified invading through the pia mater, the vascular system, the ventricular system, around neurons, and over whi... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3177037 Wed, 13 Jan 2010 06:43:57 +0100 3177037 http://www.medworm.com/index.php?rid=3168477&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq327m77372835270%2F Abstract  Malignant sweat gland tumors are rare neoplasms with high recurrence and metastasis rates of over 50%. Clinically, they are often either not diagnosed or diagnosed improperly and are encountered as a histological surprise. Herein, we report a 50-year-old woman who suffered from chronic headaches and a left-side limping gait. Magnetic resonance imaging revealed a T1 and T2 heterogeneous intense dural-based lesion at right-frontal convexity. The pathological diagnosis of papillary meningioma was rendered at the time. Because there was no evidence of residual tumor, tumor recurrence, or distant metastases during the three-year follow-up, the clinician believed questioning the initial diagnosis was warranted. After pathological review, the final diagnosis was low-grad... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3168477 Tue, 12 Jan 2010 18:19:32 +0100 3168477 http://www.medworm.com/index.php?rid=3168478&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F855p628345r0pw10%2F Abstract  Primary central nervous system lymphoma (PCNSL) remains a devastating disease with poor prognosis, despite the improvement offered by methotrexate (MTX)-based chemotherapy. Several studies have attempted to identify biomarkers predictive of prognosis, which are expected to be both clinically useful and biologically important for understanding PCNSL. The present study attempts to classify human immunodeficiency virus (HIV)-unrelated PCNSL patients treated with radiation combined with rapid high-dose MTX chemotherapy according to B-cell differentiation status, and retrospectively examines the prognostic impact. Initial response to MTX was a strong predictor of favorable prognosis in terms of both progression-free survival (PFS) and overall survival (OS). Thirteen ou... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3168478 Tue, 12 Jan 2010 18:19:31 +0100 3168478 http://www.medworm.com/index.php?rid=3168479&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy352252m28188244%2F Abstract  Ependymomas are glial tumours representing approximately 5–10% of all intracranial tumours and are the third most common primary brain tumour in childhood. Only a few karyotypic studies on paediatric ependymomas have been published and no specific chromosomal aberration has been specifically related to this type of cancer. We performed cytogenetic analysis of an ependymoma in an 11-year-old boy. Our patient showed a complex karyotype, characterized by a near-tetraploidy and a sole structural unbalanced aberration: der(2)t(2;11)(q11.2;q13.1), which has not been described before. We here discuss such cytogenetic findings, comparing our data with those reported in the literature. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-0108-xAuthors... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3168479 Tue, 12 Jan 2010 06:45:10 +0100 3168479 http://www.medworm.com/index.php?rid=3168480&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F75766r4105274628%2F Abstract  Irinotecan (CPT-11) has shown emerging promise in the treatment of malignant gliomas. It is believed the mechanism of action of irinotecan is to sensitize glioma cells to the cytotoxic action of radiation therapy and alkylating agents. However, clinical trials using weekly or three-weekly doses of CPT-11 have demonstrated imaging responses in only 10–15% of patients. In this study, we evaluated another mechanism of action, angiosuppression by CPT-11 of ACNU-resistant gliomas, using a metronomic administration schedule. Two different types of treatment, (1) conventional and (2) metronomic, were applied to the subcutaneous U87 model. We found that metronomic administration of CPT-11 significantly inhibited malignant glioma growth by inhibiting angiogenesis; this t... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3168480 Tue, 12 Jan 2010 06:45:09 +0100 3168480 http://www.medworm.com/index.php?rid=3168481&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl36w611433084881%2F We present a case of two primary intracranial tumors occurring simultaneously at adjacent sites. Preoperative gadolinium-enhanced magnetic resonance imaging of these tumors revealed a single continuous lesion. Postoperative histological examination revealed the presence of two distinct tumors, meningioma and glioblastoma multiforme. To elucidate the mechanism of synchronous tumor formation, we performed immunohistochemical analysis of the proteins involved in the receptor tyrosine kinase, Wnt, and Notch signaling pathways. These analyses showed that platelet-derived growth factor (PDGF) receptors-α and β were overexpressed in both tumors, thereby indicating the oncogenic effects of activated signaling of these receptors. The PDGF-mediated paracrine system may induce one tumor from ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3168481 Sun, 10 Jan 2010 06:44:46 +0100 3168481 http://www.medworm.com/index.php?rid=3168482&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3322753p12084p25%2F Abstract  DTI-015 (BCNU dissolved in ethanol) utilizes solvent facilitated perfusion (SFP) for intratumoral drug delivery. A phase II clinical trial of DTI-015 and fractionated external beam radiotherapy on newly diagnosed, malignant gliomas investigated early changes in tumour physiology and metabolism, clinical outcome and safety. Pre- and post DTI-015 injection neuro-imaging included computed tomography (CT) cerebral blood flow and volume, glucose and thallium single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI). Clinical status was determined before and after DTI-015, prior to radiotherapy and 3 monthly thereafter until progression (defined by Macdonald criteria). Primary endpoint was radiographic response. Secondary endpoints wer... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3168482 Sun, 10 Jan 2010 06:44:38 +0100 3168482 http://www.medworm.com/index.php?rid=3160625&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5t12788832010715%2F The objective of this study was to analyze the different expression of ERmRNA and D2RmRNA isoforms in prolactinomas responsive and resistant to dopamine agonist (DA), and to discuss the correlation of such gene expression with tumor biological behavior. A prospective study of 20 consecutive patients who harbored prolactinomas was designed. Patients were classified as responsive (14 cases) or resistant (six cases) according to their clinical and biochemical response to bromocriptine. Tumor tissue samples were examined by means of QRT–PCR analysis. Median D2SmRNA expression in responsive patients was about 2.5-fold that in resistant ones (13.5 ± 10.4 and 5.4 ± 2.4, respectively, P = 0.09). No significant difference was found between D2LmRNA expression ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3160625 Fri, 08 Jan 2010 21:39:32 +0100 3160625 http://www.medworm.com/index.php?rid=3160626&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc2n22566r7518m64%2F Abstract  Malignant primary glial and secondary metastatic brain tumors represent distinct pathological entities. Nevertheless, both tumor types induce profound angiogenic responses in the host brain microvasculature that promote tumor growth. We hypothesized that primary and metastatic tumors induce similar microvascular changes that could function as conserved angiogenesis based therapeutic targets. We previously isolated glioma endothelial marker genes (GEMs) that were selectively upregulated in the microvasculature of proliferating glioblastomas. We sought to determine whether these genes were similarly induced in the microvasculature of metastatic brain tumors. RT-PCR and quantitative RT-PCR were used to screen expression levels of 20 candidate GEMs in primary and meta... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3160626 Fri, 08 Jan 2010 21:39:31 +0100 3160626 http://www.medworm.com/index.php?rid=3160627&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu462801827721646%2F Abstract  Irinotecan has radiosensitizing effects and shows synergism with nitrosoureas. We performed a Phase II study of RT and irinotecan, followed by BCNU plus irinotecan in newly-diagnosed GBM. The MTD for patients receiving enzyme-inducing anticonvulsants (EIAC) was as follows: irinotecan 400 mg/m2/week on Days 1, 8, 22 and 29 during RT, followed by BCNU 100 mg/m2 Day 1, and irinotecan, 400 mg/m2 on Days 1, 8, 22 and 29, every 6 weeks. The MTD for non-EIAC patients was as follows: irinotecan 125 mg/m2/week on Days 1, 8, 22 and 29 during RT, followed by BCNU 100 mg/m2 Day 1 and irinotecan 75 mg/m2 Days 1, 8, 22 and 29, every 6 weeks. Median OS was 10.8 mos. (95% CI: 7.7–14.9); OS at 12 months was 44.6% (95% CI: 33.3–59.8) an... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3160627 Fri, 08 Jan 2010 21:39:30 +0100 3160627 http://www.medworm.com/index.php?rid=3160628&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw788n476r40604k3%2F Abstract  Upfront temozolomide (TMZ) is often proposed for elderly patients with malignant gliomas as an alternative to radiotherapy (RT). A recent randomized trial showed that RT provides a survival benefit in elderly glioblastoma patients (≥70 years) with good performance status (KPS ≥ 70) compared with supportive care alone (median survival (MS) = 29.1 vs. 16.9 weeks). We retrospectively analyzed all patients who were eligible for this trial, but who refused to participate and were finally treated with TMZ alone. Thirty-nine eligible patients (median age: 75 years (range 70–83), median KPS: 70 (range 70–80), histologically proven glioblastomas) were treated up-front with oral TMZ for 1–12 cycles (mean = 5). One comple... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3160628 Thu, 07 Jan 2010 22:22:13 +0100 3160628 http://www.medworm.com/index.php?rid=3160629&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fml7495015517p568%2F Abstract  After stereotactic radiosurgery (SRS) for brain metastases, delayed radiation effects with mass effect may occur from several months to years later, when tumors may also recur. Aggressive salvage treatment would be beneficial for patients with recurrence, but may be contraindicated for those with dominant radiation effect. Conventional magnetic resonance (MR) imaging does not provide sufficient information to differentiate delayed radiation effects from tumor recurrence. Positron emission tomography, MR spectroscopy, and other modalities sometimes may lead to false findings of tumor recurrence. We prospectively applied perfusion MR imaging for the management strategy after SRS because it gives microvascular information about the lesions. Twenty-eight lesions were ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3160629 Thu, 07 Jan 2010 22:22:12 +0100 3160629 http://www.medworm.com/index.php?rid=3154194&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq9672g1m05751g85%2F Abstract  Primary central nervous system lymphoma (PCNSL) is rare. Clinical and histological differential diagnosis of systemic lymphoma and sarcoidosis continues to be a challenge. The first case report in the German and English literature of PCNSL and synchronous sarcoidosis is presented. Synchronous mediastinal lymphadenopathy suggestive of non-Hodgkin’s lymphoma (NHL) or sarcoidosis was noted. Both conditions require alternative therapeutic and prognostic considerations to PCNSL. A regime of intrathecal and adjuvant systemic chemotherapy led to transient clinical improvement prior to the patient’s demise through overwhelming sepsis and multiorgan failure. Post mortem findings confirmed synchronous PCNSL with mediastinal lymph node sarcoidosis. Content Type Journal... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3154194 Wed, 06 Jan 2010 18:05:46 +0100 3154194 http://www.medworm.com/index.php?rid=3154195&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2174782563k885p0%2F Abstract  Little is known about the cytogenetic and molecular genetic events that lead to the formation of paediatric astrocytoma. We have analysed 57 paediatric astrocytoma (WHO grades I–IV) using comparative genomic hybridisation in order to identify common regions of abnormality. Large regions of copy number alterations were infrequent with 71% of tumours demonstrating no genomic imbalance. Furthermore, the most frequent aberrations (including gain of 6q, 2q, and 7q, and loss of 16 and 12q) occurred in only a subset of cases. High-copy number amplification was seen in five tumours at 12 different regions. The presence of copy number alterations was significantly associated with increasing grade of malignancy, and gain of 12q and the presence of high-copy number amplifi... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3154195 Wed, 06 Jan 2010 06:50:12 +0100 3154195 http://www.medworm.com/index.php?rid=3136183&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F115231u4q62r8883%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s11060-009-0099-7Authors Mark E. Linskey, University of California-Irvine Medical Center Department of Neurosurgery Orange CA USADavid W. Andrews, Thomas Jefferson University Department of Neurosurgery Philadelphia PA USAAnthony L. Asher, Carolina Neurosurgery and Spine Associates Department of Neurosurgery Charlotte NC USAStuart H. Burri, Carolinas Medical Center Department of Radiation Oncology Charlotte NC USADouglas Kondziolka, University of Pittsburgh Medical Center Department of Neurological Surgery Pittsburgh PA USAPaula D. Robinson, McMaster University Evidence-based Practice Center Hamilton ON CanadaMario Ammirati, Ohio State University Medical Center Department of Neurosurgery Columbus OH USACharles S. Cobbs, California ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3136183 Thu, 31 Dec 2009 16:45:18 +0100 3136183 http://www.medworm.com/index.php?rid=3134319&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F17431910l4073044%2F Abstract  To characterize a population of pediatric high-grade astrocytoma (HGA) patients by confirming the proportion with a correct diagnosis, and determine prognostic factors for survival in a subset diagnosed with uniform pathologic criteria. Sixty-three children diagnosed with HGA were treated at the Johns Hopkins Hospital between 1977 and 2004. A single neuropathologist (P.C.B.) reviewed all available histologic samples (n = 48). Log-rank analysis was used to compare survival by patient, tumor, and treatment factors. Median follow-up was 16 months for all patients and 155 months (minimum 54 months) for surviving patients. Median survival for all patients (n = 63) was 14 months with 10 long-term survivors (survival >48 mont... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3134319 Wed, 30 Dec 2009 16:45:25 +0100 3134319 http://www.medworm.com/index.php?rid=3134318&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh02gx1g6855k1437%2F We present the case of a 48-year old man with brainstem fibrosarcoma 20 years following radiation therapy received for a pituitary tumor. We discuss this case in the context of the diagnostic criteria for these tumors, and previous reports of secondary and primary sarcomas of the central nervous system. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-0096-xAuthors Daniela Alexandru, University of California, Irvine Department of Neurological Surgery Irvine CA USADenise K. Van Horn, Hoag Hospital Department of Pathology Newport Beach CA USADaniela Annenelie Bota, University of California, Irvine Department of Neurology Irvine CA USA Journal Journal of Neuro-OncologyOnline ISSN 1573-7373Print ISSN 0167-594X (Source: Journal of Neuro-Oncology) Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3134318 Wed, 30 Dec 2009 16:45:25 +0100 3134318 http://www.medworm.com/index.php?rid=3130560&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F60138122p153vjw1%2F Abstract  The authors report their 27-year experience regarding 35 cases of supratentorial brain metastasis from sarcoma treated in a single institution: these included ten osteosarcomas, seven leiomyosarcomas, five Ewing sarcomas, four malignant fibrous histiocytomas, three alveolar soft-part sarcomas (ASPS), two rhabdomyosarcomas, one liposarcoma, and three unclassified sarcomas. The first 15 cases of the series have already been described in a previous publication. Median survival after craniotomy was 9.8 months (range: 4–24). In patients with preoperative Karnofsky performance score (KPS) > 60 it was 12.8 months (range: 6.5–24 months) versus 5.4 months for those patients with a KPS ≤ 60 (P = 0.01). Eight patients... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3130560 Tue, 29 Dec 2009 06:54:44 +0100 3130560 http://www.medworm.com/index.php?rid=3122736&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp21m236v3x23094q%2F This study is to further examine the expression of SEPT7 in glioma samples and characterizes its role on cell cycle progression and growth of glioma cells. mRNA and protein expression of SEPT7 were detected by RT-PCR, immunohistochemical staining, and western blot analysis in human glioma specimens and normal brain tissues. A pcDNA3-SEPT7 expression plasmid was constructed and transfected into human glioblastoma cell line U251, and cell proliferation and apoptosis were examined. The growth of established U251 and TJ905 subcutaneous xenograft gliomas was measured in nude mice treated with pcDNA3-SEPT7 and U251 xenograft tumors treated with SEPT7 siRNA. SEPT7 expression is negatively correlated with the increase of glioma grade. Overexpression of SEPT7 is able to inhibit cell prolifer... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3122736 Fri, 25 Dec 2009 00:19:49 +0100 3122736 http://www.medworm.com/index.php?rid=3122737&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn077mt723p447h4w%2F Abstract  It has been reported recently that oligodendroglial tumors arising in the insula rarely harbor co-deletions of chromosomes 1p and 19q, a molecular signature which is associated with a good prognosis and increased responsiveness to radiation and chemotherapy compared with tumors in which 1p and/or 19q is intact. In the context of this claim, we analyzed a series of insular oligodendroglial tumors in order to determine the frequency of 1p/19q co-deletion in tumors arising in this region. We identified 14 insular cases operated on after 2003 in which testing for losses of 1p and 19q was performed. Of these cases, co-deletion of 1p and 19q occurred in eight (57%). Four (50%) of eight oligodendrogliomas and four (67%) of six oligoastrocytomas demonstrated 1p/19q co-del... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3122737 Fri, 25 Dec 2009 00:19:48 +0100 3122737 http://www.medworm.com/index.php?rid=3122738&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnp015175k778567j%2F Abstract  Bevacizumab is an anti-vascular endothelial growth factor (VEGF) antibody with activity against recurrent malignant glioma inducing high rates of objective responses as assessed by magnetic resonance imaging (MRI). However, the mechanisms of the anti-tumor action of bevacizumab are controversial. In particular, it is unclear whether and when bevacizumab induces hypoxia in gliomas. Vascular normalization with hyperperfusion and enhanced oxygen delivery to the tumor has been suggested as an alternative mechanism. We analyzed diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) maps in 18 consecutive patients with recurrent malignant glioma before and after exposure to bevacizumab. Stroke-like lesions with diffusion restriction on DWI and corresp... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3122738 Fri, 25 Dec 2009 00:19:47 +0100 3122738 http://www.medworm.com/index.php?rid=3122739&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fytmm952024006378%2F Abstract  The authors present two cases that illustrate the difficulty in radiographically distinguishing between meningioma and metastatic lesions in patients with known cancer, especially with a parafalcine tumor location. The first patient with known metastatic prostate cancer had imaging studies suggestive of a parafalcine meningioma, but after surgical resection the lesion was found to be histologically consistent with metastatic disease. Conversely, the second patient was thought to have a metastatic breast cancer lesion in the parafalcine region. This presumptive diagnosis based on imaging findings led the patient to undergo radiosurgery treatment; however, the lesion grew over a several-month course and was eventually resected. The pathological analysis revealed tha... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3122739 Thu, 24 Dec 2009 19:45:58 +0100 3122739 http://www.medworm.com/index.php?rid=3121215&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn45715524u271163%2F Abstract  Non-invasive loco-regional electro-hyperthermia (EHT) plus alkylating chemotherapy is occasionally used as salvage treatment in the relapse of patients with high-grade gliomas. Experimental data and retrospective studies suggest potential effects. However, no prospective clinical results are available. We performed a single-center prospective non-controlled single-arm Phase I trial. Main inclusion criteria were recurrent high-grade glioma WHO Grade III or IV, age 18–70, and Karnofsky performance score ≥70. Primary endpoints were dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) with the combined regimen. Groups of 3 or 4 patients were treated 2–5 times a week in a dose-escalation scheme with EHT. Alkylating chemotherapy (ACNU, nimustin) was adm... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3121215 Wed, 23 Dec 2009 22:36:24 +0100 3121215 http://www.medworm.com/index.php?rid=3105939&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk75u05476hqv0p34%2F In conclusion, our findings support an important role of Gli1 in cell-cycle and apoptosis regulation in human brain gliomas; hence, it can serve as a potential target of new therapeutic strategies for these diseases. Content Type Journal ArticleCategory Laboratory Investigation - Human/Animal TissueDOI 10.1007/s11060-009-0082-3Authors Ke Wang, Huashan Hospital, Fudan University Department of Neurosurgery Shanghai 200040 ChinaLi Pan, Huashan Hospital, Fudan University Department of Neurosurgery Shanghai 200040 ChinaXiaoming Che, Huashan Hospital, Fudan University Department of Neurosurgery Shanghai 200040 ChinaDaming Cui, Huashan Hospital, Fudan University Department of Neurosurgery Shanghai 200040 ChinaChao Li, Huashan Hospital, Fudan University Department of Neuropathology Shanghai... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3105939 Fri, 18 Dec 2009 16:08:23 +0100 3105939 http://www.medworm.com/index.php?rid=3105940&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkt7866228557n663%2F In this report, we describe a very unusual case of a child who presented with signs and symptoms suggestive of leptomeningitis. However, imaging studies and histologic findings showed plaque-like AT/RT involving the leptomeninges of the cerebrum, cerebellum, and spinal cord. The disease proved to be rapidly fatal and resulted in the patient’s death within approximately two weeks. To our knowledge, this is the first case of primary leptomeningeal AT/RT involving the supratentorial leptomeninges. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-0094-zAuthors Bassem El-Nabbout, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital Department of Neurology One children’s Way Little Rock AR 72202 USARolla Shbarou, University of Arkansas... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3105940 Fri, 18 Dec 2009 07:22:40 +0100 3105940 http://www.medworm.com/index.php?rid=3105943&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy512471xh6u6mw25%2F Abstract  Temporal paragangliomas are highly vascular tumors treated primarily by surgical resection. However, surgery to remove these tumors is associated with significant morbidity, including cranial nerve dysfunction. Interestingly, these tumors have been shown to express vascular endothelial growth factor (VEGF). A variety of tumors expressing VEGF and the VEGF receptor have been shown to reduce in size and vascularity when treated with the VEGF-specific antibody, bevacizumab (Avastin®). We hypothesized that paragangliomas may be treated noninvasively with bevacizumab, either as a primary treatment or as a useful adjuvant to surgical resection or radiation. Thus, our aim was to evaluate the effects of bevacizumab on this patient’s paraganglioma. A 36-year-old female p... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3105943 Fri, 18 Dec 2009 07:10:04 +0100 3105943 http://www.medworm.com/index.php?rid=3105942&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fywup7520351m6140%2F This study also provides a lentiviral vector design for safer gene therapy. Content Type Journal ArticleCategory Laboratory Investigation - Human/Animal TissueDOI 10.1007/s11060-009-0095-yAuthors Marie-Josée Beaudet, Laval University Hospital Research Center Department of Endocrinology and Genomics 2705 Laurier Boulevard Quebec City QC G1V 4G2 CanadaNaika Rueda, Laval University Hospital Research Center Department of Endocrinology and Genomics 2705 Laurier Boulevard Quebec City QC G1V 4G2 CanadaGary P. Kobinger, Public Health Agency of Canada National Microbiology Laboratory Winnipeg MB CanadaJérôme Villeneuve, Laval University Hospital Research Center Department of Endocrinology and Genomics 2705 Laurier Boulevard Quebec City QC G1V 4G2 CanadaLuc Vallières, Laval University Hosp... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3105942 Fri, 18 Dec 2009 07:10:04 +0100 3105942 http://www.medworm.com/index.php?rid=3105941&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq92096637w385p65%2F Abstract  We have retrospectively reviewed toxicities and response of a cohort of primary central nervous system lymphoma (PCNSL) patients treated with high dose parenteral methotrexate (MTX) monotherapy without whole brain radiation. From The Massachusetts General Hospital (MGH) Cancer Registry, active since 1946, we selected all immunocompetent patients with histologic and/or radiographic PCNSL diagnosed between 1980 and 2007. We identified the recipients of MTX with leucovorin rescue as sole therapy. No patient received radiation therapy (XRT). We analyzed this cohort for toxicity, response and patterns of recurrence. The cohort of 121 patients received on average 11 cycles of intravenous MTX at a median dose of 8 g/m2. Median interval between cycles was 10 days... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3105941 Fri, 18 Dec 2009 07:10:04 +0100 3105941 http://www.medworm.com/index.php?rid=3097670&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff63781x1262111r4%2F Abstract  Meningiomas are benign tumors, with low rate of recurrence after surgery. The most important factor predicting recurrence is the extent of surgical resection; other factors have been studied with conflicting results. Angiogenesis, an important substratum for growth and spread of neoplasic cells, and the expression of estrogen and progesterone receptors (ER, PR), could play a role in the recurrence of meningioma. We evaluated 42 patients with meningioma diagnosis (confirmed by histopathology) treated exclusively by surgery between January 1995 and December 1999, and compared the recurring and non-recurring groups after a ten-year follow-up period. Recurrence was associated with several factors including vascular density (VD), cell proliferation index (CPI), ER, PR,... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3097670 Tue, 15 Dec 2009 07:08:02 +0100 3097670 http://www.medworm.com/index.php?rid=3097669&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7j02t03514460676%2F We report herein a clinical case of a patient with meningeal carcinomatosis from penile squamous cell carcinoma. A 68-year-old man presented with mental changes, headaches, and unstable gait. Examinations revealed brain metastases and infiltration of the leptomeninges and subarachnoid space by carcinoma cells. Only 11 months earlier the patient had been diagnosed with penile squamous cell carcinoma of poor differentiation and had underwent subtotal penectomy and adjuvant chemotherapy and radiation. Infiltration of the central nervous system with penile cancer is extremely rare, and only five cases with brain metastases have been described to date. This is the first report of a patient with penile cancer spread to the leptomeninges. Content Type Journal ArticleCategory Case Rep... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3097669 Tue, 15 Dec 2009 07:08:02 +0100 3097669 http://www.medworm.com/index.php?rid=3097671&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe771r61j17808251%2F Abstract  A summary is presented of four case studies of extensive disease small-cell lung cancer patients with initial symptomatic brain metastases, who were initially successfully treated with concurrent chemoradiotherapy of the neurocranium followed by consolidation chemotherapy and thoracic chemoradiotherapy, but shortly after the initial treatment developed a sequence of central nervous system relapses despite second-line therapy. Symptoms of the effect on the central nervous system dominated the course of the cancer disease, whereas the primary tumor mass remained in complete remission in all four patients until the end of the follow-up period. Content Type Journal ArticleCategory Clinical Study - Patient StudyDOI 10.1007/s11060-009-0079-yAuthors Farkhad Manapov, ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3097671 Tue, 15 Dec 2009 07:08:00 +0100 3097671 http://www.medworm.com/index.php?rid=3090179&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj08502831657163h%2F Abstract  The aim of this work is to evaluate patterns of failure in patients with recurrent meningioma after stereotactic radiotherapy. Of 411 patients with intracranial meningioma treated with radiotherapy at our institution, 22 patients with local tumor progression diagnosed by magnetic resonance imaging (MRI) after radiotherapy (RT) were identified and further investigated. The histologic grade of the meningiomas was World Health Organization (WHO) grade I in 54.5%, WHO grade II in 27.3%, and WHO grade III in 9.1% of cases. Fourteen patients had received fractionated stereotactic RT; five patients underwent intensity-modulated RT. The median total dose was 57.6 Gy at 1.8 Gy/fraction, five times weekly. Local recurrences were divided into the dosi... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3090179 Sun, 13 Dec 2009 06:42:06 +0100 3090179 http://www.medworm.com/index.php?rid=3090180&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh6t1jr24361472x4%2F Abstract  Several biomarkers have been identified as prognostic factors in primary central nervous system lymphoma (PCNSL). However, the correlation between the histogenetic origin of PCNSL and the response to therapy is still unclear. To elucidate the utility of immunophenotypic markers in predicting clinical outcomes, we investigated 27 immunocompetent patients with PCNSL treated with high-dose methotrexate therapy. Of the 27 patients, 25 received whole-brain radiotherapy after high-dose methotrexate. Immunostaining for CD5, CD10, BCL-6, and MUM-1 was used to determine the immunophenotypic profile of diffuse large B-cell lymphoma of PCNSL. We then evaluated whether immunophenotypic markers were associated with the response to therapy or patients’ survival. The response ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3090180 Sun, 13 Dec 2009 06:42:04 +0100 3090180 http://www.medworm.com/index.php?rid=3090181&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F21q1793745555607%2F We present identical twin sisters with meningiomas. The tumors were located at a similar, but not a common, position (the cerebellopontine angle) in both twins. Histologically, both tumors were diagnosed as meningothelial meningiomas with an angiomatous component. Immunohistochemically, the Ki-67 indices in the two cases were 1.0 and 1.1, and the p53 positive rates were 0.2 and 0.9. The specimens in both cases were reactive to neurofibromin 2 (NF2). A comparative genomic hybridization (CGH) assay revealed an aberration in the long arm of chromosome X, but no aberrations in the long arm of chromosome 22 in either case. These results strongly suggest that genetic aberrations other than NF2 are associated with tumorigenesis in some types of sporadic meningiomas. Content Type Journal A... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3090181 Sat, 12 Dec 2009 14:18:15 +0100 3090181 http://www.medworm.com/index.php?rid=3090182&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F64574778136330un%2F Abstract  We have evaluated the efficacy of intracerebral (i.c.) convection-enhanced delivery (CED) of cisplatin in combination with photon irradiation for the treatment of F98 glioma-bearing rats. One thousand glioma cells were stereotactically implanted into the brains of Fischer rats and 13 days later cisplatin (6 μg/20 μl) was administered i.c. by CED at a flow rate of 0.5 μl/min. On the following day the animals were irradiated with a single 15 Gy dose of X-rays, administered by a linear accelerator (LINAC) or 78.8 keV synchrotron X-rays at the European Synchrotron Radiation Facility (ESRF). Untreated controls had a mean survival time (MST) ± standard error of 24 ± 1 days compared to >59 ± 13&nbsp... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3090182 Fri, 11 Dec 2009 06:53:02 +0100 3090182 http://www.medworm.com/index.php?rid=3090183&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw05809h3t1782595%2F Content Type Journal ArticleCategory Book ReviewDOI 10.1007/s11060-009-0088-xAuthors Paul Kleihues, University Hospital Department of Pathology 8091 Zurich Switzerland Journal Journal of Neuro-OncologyOnline ISSN 1573-7373Print ISSN 0167-594X (Source: Journal of Neuro-Oncology) Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3090183 Fri, 11 Dec 2009 06:53:01 +0100 3090183 http://www.medworm.com/index.php?rid=3090184&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu7k165246450v51u%2F Abstract  Intracranial chondromas are uncommon benign lesions usually attached to dura and located over the convexity of the skull. Osteochondromas are even rarer and additionally contain a benign bony component. Both lesions are reportedly difficult to distinguish from meningiomas on pre-operative neuroimaging studies, although few detailed pathologic-neuroimaging correlation studies have appeared in the literature, particularly for intracranial osteochondromas. A 33-year-old woman with a 4-year history of headaches presented with recent onset of left-sided muscle spasms and weakness. Two days prior to admission to our hospital, neuroimaging studies had shown a large right convexity mass with unusual multifocal bright signal intensities throughout an otherwise isointense m... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3090184 Thu, 10 Dec 2009 15:10:09 +0100 3090184 http://www.medworm.com/index.php?rid=3090185&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft81551t876k146t6%2F We report the sixth, and first noninfantile, case of DIA/DIG with multifocal initial presentation. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-0075-2Authors E. Uro-Coste, Rangueil University Hospital Department of Pathology Toulouse FranceG. Ssi-Yan-Kai, Rangueil University Hospital Department of Pathology Toulouse FranceC. Guilbeau-Frugier, Rangueil University Hospital Department of Pathology Toulouse FranceS. Boetto, Purpan University Hospital Department of Neurosurgery Toulouse FranceA. I. Bertozzi, Children University Hospital Department of Haematology-Oncology Toulouse FranceA. Sevely, Purpan University Hospital Department of Radiology Toulouse FranceK. Lolmede, INSERM U858 Toulouse FranceM. B. Delisle, Rangueil University Hospital Department of Pathol... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3090185 Thu, 10 Dec 2009 15:10:07 +0100 3090185 http://www.medworm.com/index.php?rid=3080331&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy7631047xmm77110%2F Abstract  Fifty-seven spontaneous canine gliomas were histologically classified and graded using the latest World Health Organization (WHO 2007) criteria for classification of human gliomas. A total of 19 canine astrocytomas were classified as follows: grade IV (GBM) n = 7; grade III n = 5; and grade II, n = 7. Thirty-eight oligodendrogliomas were classified as either grade III (anaplastic) n = 35 or low grade II n = 3. Tissue microarray (TMA) immunohistochemistry was used to evaluate tumor expression of EGFR, PDGFRa and IGFBP2, three key molecules of known pathophysiological importance in human gliomas. Findings were correlated with tumor classification and grade. Increased EGFR expression was demonstrated in 57% of GBMs, 40%... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3080331 Fri, 04 Dec 2009 21:17:40 +0100 3080331 http://www.medworm.com/index.php?rid=3064094&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl467p704762u5541%2F Abstract  Approximately 40–50% of glioblastomas (GBM) overexpress epidermal growth factor receptor (EGFR). Erlotinib is a specific and potent EGFR tyrosine kinase inhibitor active against refractory GBM. Patients with non-small cell lung cancer and ≥grade 2 erlotinib-induced rash have improved survival. This phase 2 study assessed the efficacy and safety of concurrent radiation therapy (RT) and temozolomide with pharmacodynamic dose escalation of erlotinib in patients with newly diagnosed GBM. Patients received RT 60 Gy in 30 fractions with concurrent temozolomide 75 mg/m2/day × 42 days, followed in four weeks by temozolomide 150–200 mg/m2/day × 5, every 28 days for 12 cycles. Patients received erlotinib, 50 mg/day and... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064094 Fri, 04 Dec 2009 07:20:01 +0100 3064094 http://www.medworm.com/index.php?rid=3064095&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7w84227x88442213%2F Abstract Question   Should patients with newly-diagnosed metastatic brain tumors undergo stereotactic radiosurgery (SRS) compared with other treatment modalities? Target population These recommendations apply to adults with newly diagnosed solid brain metastases amenable to SRS; lesions amenable to SRS are typically defined as measuring less than 3 cm in maximum diameter and producing minimal (less than 1 cm of midline shift) mass effect. Recommendations SRS plus WBRT vs. WBRT alone Level 1 Single-dose SRS along with WBRT leads to significantly longer patient survival compared with WBRT alone for patients with single metastatic brain tumors who have a KPS ≥ 70. Level 2 Single-dose SRS along with W... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064095 Thu, 03 Dec 2009 18:21:57 +0100 3064095 http://www.medworm.com/index.php?rid=3064096&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe088515136888570%2F Abstract Question   Should patients with newly-diagnosed metastatic brain tumors undergo open surgical resection versus whole brain radiation therapy (WBRT) and/or other treatment modalities such as radiosurgery, and in what clinical settings? Target population These recommendations apply to adults with a newly diagnosed single brain metastasis amenable to surgical resection. Recommendations Surgical resection plus WBRT versus surgical resection alone Level 1 Surgical resection followed by WBRT represents a superior treatment modality, in terms of improving tumor control at the original site of the metastasis and in the brain overall, when compared to surgical resection alone. Surgical resection plus WBRT versus SRS �... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064096 Thu, 03 Dec 2009 18:21:55 +0100 3064096 http://www.medworm.com/index.php?rid=3064097&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm42x58l615326720%2F Abstract Target population  This recommendation applies to adults with newly diagnosed brain metastases; however, the recommendation below does not apply to the exquisitely chemosensitive tumors, such as germinomas metastatic to the brain. Recommendation   Should patients with brain metastases receive chemotherapy in addition to whole brain radiotherapy (WBRT)? Level 1 Routine use of chemotherapy following WBRT for brain metastases has not been shown to increase survival and is not recommended. Four class I studies examined the role of carboplatin, chloroethylnitrosoureas, tegafur and temozolomide, and all resulted in no survival benefit. Two caveats are provided in order to allow the treating physician to individualize decision-making: First, the ma... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064097 Thu, 03 Dec 2009 18:21:54 +0100 3064097 http://www.medworm.com/index.php?rid=3064098&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv2k003021882774p%2F Abstract Should whole brain radiation therapy (WBRT) be used as the sole therapy in patients with newly-diagnosed, surgically accessible, single brain metastases, compared with WBRT plus surgical resection, and in what clinical settings?   Target population This recommendation applies to adults with newly diagnosed single brain metastases amenable to surgical resection; however, the recommendation does not apply to relatively radiosensitive tumors histologies (i.e., small cell lung cancer, leukemia, lymphoma, germ cell tumors and multiple myeloma). Recommendation Surgical resection plus WBRT versus WBRT alone Level 1 Class I evidence supports the use of surgical resection plus post-operative WBRT, as compared to WBRT alone, in patients wi... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064098 Thu, 03 Dec 2009 18:21:53 +0100 3064098 http://www.medworm.com/index.php?rid=3064099&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm42866046j3033pt%2F We describe the case of a 32-year-old man affected by relapsing-remitting MS who experienced the first MS clinical event during the development of a prolactin-secreting adenoma and the only two MS relapses during adenoma recurrence. Prolactin may have facilitated the inflammatory process and triggered MS clinical attacks, suggesting a role of prolactin in immunomodulation and therefore in autoimmune disease course. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-0076-1Authors V. Nociti, Catholic University Institute of Neurology, Department of Neurosciences Largo Agostino Gemelli, 8 00168 Rome ItalyG. Frisullo, Catholic University Institute of Neurology, Department of Neurosciences Largo Agostino Gemelli, 8 00168 Rome ItalyT. Tartaglione, Catholic University ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064099 Thu, 03 Dec 2009 12:50:12 +0100 3064099 http://www.medworm.com/index.php?rid=3064100&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvw55868761322267%2F Abstract Question   What evidence is available regarding the emerging and investigational therapies for the treatment of metastatic brain tumors? Target population These recommendations apply to adults with brain metastases. Recommendations New radiation sensitizers Level 2 A subgroup analysis of a large prospective randomized controlled trial (RCT) suggested a prolongation of time to neurological progression with the early use of motexafin-gadolinium (MGd). Nonetheless this was not borne out in the overall study population and therefore an unequivocal recommendation to use the currently available radiation sensitizers, motexafin-gadolinium and efaproxiral (RSR 13) cannot be provided. Interstitial modalities Ther... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064100 Thu, 03 Dec 2009 12:50:11 +0100 3064100 http://www.medworm.com/index.php?rid=3064101&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn11832031700653r%2F Discussion” and “Summary” section for additional details. Content Type Journal ArticleCategory Invited ManuscriptDOI 10.1007/s11060-009-0057-4Authors Timothy C. Ryken, Iowa Spine and Brain Institute Department of Neurosurgery Iowa City IA USAMichael McDermott, University of California San Francisco Department of Neurosurgery San Francisco CA USAPaula D. Robinson, McMaster University Evidence-Based Practice Centre Hamilton ON CanadaMario Ammirati, Ohio State University Medical Center Department of Neurosurgery Columbus OH USADavid W. Andrews, Thomas Jefferson University Department of Neurosurgery Philadelphia PA USAAnthony L. Asher, Carolina Neurosurgery and Spine Associates Department of Neurosurgery Charlotte NC USAStuart H. Burri, Carolinas Medical Center Department of... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064101 Wed, 02 Dec 2009 18:44:13 +0100 3064101 http://www.medworm.com/index.php?rid=3064104&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl91365558247u148%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s11060-009-0070-7Authors Mark E. Linskey, University of California Department of Neurological Surgery, UC Irvine Medical Center Bldg 56, Suite 400, 101 The City Drive South Orange CA 92868 USASteven N. Kalkanis, Henry Ford Health System Detroit MI USA Journal Journal of Neuro-OncologyOnline ISSN 1573-7373Print ISSN 0167-594X (Source: Journal of Neuro-Oncology) Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064104 Wed, 02 Dec 2009 18:44:11 +0100 3064104 http://www.medworm.com/index.php?rid=3064103&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv69317g735r2381m%2F Abstract Question   Do prophylactic anticonvulsants decrease the risk of seizure in patients with metastatic brain tumors compared with no treatment? Target population These recommendations apply to adults with solid brain metastases who have not experienced a seizure due to their metastatic brain disease. Recommendation Level 3 For adults with brain metastases who have not experienced a seizure due to their metastatic brain disease, routine prophylactic use of anticonvulsants is not recommended. Only a single underpowered randomized controlled trial (RCT), which did not detect a difference in seizure occurrence, provides evidence for decision-making purposes. Content Type Journal ArticleCategory Invited ManuscriptDOI 10.... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064103 Wed, 02 Dec 2009 18:44:11 +0100 3064103 http://www.medworm.com/index.php?rid=3064102&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd842488756085422%2F Content Type Journal ArticleCategory Invited ManuscriptDOI 10.1007/s11060-009-0059-2Authors Paula D. Robinson, McMaster University Evidence-based Practice Center Hamilton ON CanadaSteven N. Kalkanis, Henry Ford Health System Department of Neurosurgery 2799 West Grand Blvd, K-11 Detroit MI 48202 USAMark E. Linskey, University of California-Irvine Medical Center Department of Neurosurgery Orange CA USAP. Lina Santaguida, McMaster University Evidence-based Practice Center Hamilton ON Canada Journal Journal of Neuro-OncologyOnline ISSN 1573-7373Print ISSN 0167-594X (Source: Journal of Neuro-Oncology) Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064102 Wed, 02 Dec 2009 18:44:11 +0100 3064102 http://www.medworm.com/index.php?rid=3064105&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4711x523t24123p7%2F Abstract Question    What evidence is available regarding the use of whole brain radiation therapy (WBRT), stereotactic radiosurgery (SRS), surgical resection or chemotherapy for the treatment of recurrent/progressive brain metastases? Target population This recommendation applies to adults with recurrent/progressive brain metastases who have previously been treated with WBRT, surgical resection and/or radiosurgery. Recurrent/progressive brain metastases are defined as metastases that recur/progress anywhere in the brain (original and/or non-original sites) after initial therapy. Recommendation Level 3 Since there is insufficient evidence to make definitive treatment recommendations in patients with recurrent/progressive brain metastas... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064105 Wed, 02 Dec 2009 18:44:10 +0100 3064105 http://www.medworm.com/index.php?rid=3064106&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu5v127351828308g%2F Content Type Journal ArticleCategory Invited ManuscriptDOI 10.1007/s11060-009-0065-4Authors Steven N. Kalkanis, Henry Ford Health System Department of Neurosurgery 2799 West Grand Blvd, K-11 Detroit MI 48202 USAMark E. Linskey, University of California-Irvine Medical Center Department of Neurosurgery Orange CA USA Journal Journal of Neuro-OncologyOnline ISSN 1573-7373Print ISSN 0167-594X (Source: Journal of Neuro-Oncology) Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064106 Wed, 02 Dec 2009 18:44:09 +0100 3064106 http://www.medworm.com/index.php?rid=3064107&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn756166755h41806%2F Abstract  Cranial chordomas are rare tumors that have been difficult to study given their low prevalence. Individual case series with decades of data collection provide some insight into the pathobiology of this tumor and its responses to treatment. This meta-analysis is an attempt to aggregate the sum experiences and present a comprehensive review of their findings. We performed a comprehensive review of studies published in English language literature and found a total of over 2,000 patients treated for cranial chordoma. Patient information was then extracted from each paper and aggregated into a comprehensive database. The tumor recurrences in these patients were then stratified according to age (<21 vs. >21 years), histological findings (chondroid vs. typical)... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3064107 Wed, 02 Dec 2009 08:36:07 +0100 3064107 http://www.medworm.com/index.php?rid=3040639&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh516377r92363741%2F Abstract  High density micro-RNA (miRNA) arrays, fluorescent-reporter miRNA assay and Northern miRNA dot-blot analysis show that a brain-enriched miRNA-128 is significantly down-regulated in glioblastoma multiforme (GBM) and in GBM cell lines when compared to age-matched controls. The down-regulation of miRNA-128 was found to inversely correlate with WHO tumor grade. Three bioinformatics-verified miRNA-128 targets, angiopoietin-related growth factor protein 5 (ARP5; ANGPTL6), a transcription suppressor that promotes stem cell renewal and inhibits the expression of known tumor suppressor genes involved in senescence and differentiation, Bmi-1, and a transcription factor critical for the control of cell-cycle progression, E2F-3a, were found to be up-regulated. Addition of exo... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3040639 Thu, 26 Nov 2009 08:01:08 +0100 3040639 http://www.medworm.com/index.php?rid=3040640&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fav07u42q8817nkx5%2F Abstract  Although there are many reports on the clinical use of the MIB-1 labeling index (LI), which is a measure of proliferative activity in astrocytomas; its significance varies between studies. There are no known molecules that are directly linked to the MIB-1 LI in astrocytomas. We evaluated the clinical value of the MIB-1 LI in our human glioblastoma cases and determined the molecules that possibly influenced the MIB-1 LI. An immunohistochemical study of the MIB-1 protein was performed and MIB-1 LIs of 38 glioblastomas were determined. In the same cases, epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor-α (PDGFRA), and sphingosine-1-phosphate receptor type 1 (S1P1), which are known regulators of glioma cell proliferation, were detected ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3040640 Wed, 25 Nov 2009 16:51:28 +0100 3040640 http://www.medworm.com/index.php?rid=3040641&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F945g2q1442367864%2F Abstract  The expression of neurotrophic factors, such as artemin, glial cell line-derived neurotrophic factor (GDNF), neurturin, transforming growth factors (TGF)-β1/β2 and brain-derived neurotrophic factor (BDNF), is enhanced in vestibular schwannomas compared to peripheral nerves. Furthermore, this upregulation may correlate with mitotic activity. Vestibular schwannoma arising from Schwann cells of the vestibular nerve are mostly benign and slow-growing. Most of the pathogenic mechanisms regulating the vestibular schwannoma growth process are unknown. An impaired growth regulation and imbalance between mitosis and apoptosis can be assumed. However, molecular mechanisms interfering with regulation of the vestibular schwannoma growth also modulated by mitogenic factors h... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3040641 Wed, 25 Nov 2009 16:51:27 +0100 3040641 http://www.medworm.com/index.php?rid=3031635&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F141xu205382jl70w%2F In conclusion, regarding the use of newer antiepileptics in patients with seizures related to brain metastases, our data indicate that LEV, OXC and TPM significantly reduce seizure frequency (independently of systemic treatment), produce few side effects and appear not to affect life expectancy. Content Type Journal ArticleCategory Clinical Study - Patient StudyDOI 10.1007/s11060-009-0069-0Authors M. Maschio, National Institute for Cancer “Regina Elena” Center for Tumor-Related Epilepsy, Department of Neuroscience and Cervical-Facial Pathology Via Elio Chianesi 53 00144 Rome ItalyL. Dinapoli, National Institute for Cancer “Regina Elena” Center for Tumor-Related Epilepsy, Department of Neuroscience and Cervical-Facial Pathology Via Elio Chianesi 53 00144 Rome ItalyS. Gomellin... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3031635 Tue, 24 Nov 2009 07:10:57 +0100 3031635 http://www.medworm.com/index.php?rid=3031636&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp07q42gh30363514%2F Abstract  Craniopharyngioma (CP) is a pathologically benign tumor with high incidence of recurrence and poor prognosis. DNA ploidy, S-phase fraction (SPF), and G2 phase/mitosis phase + S phase (G2/M + S) measured by flow cytometry (FCM) have been shown to correlate with cell cycle characteristics and clinical prognosis of other tumors. By use of FCM and terminal deoxynucleotide transferase-mediated dUTP nick end labeling (TUNEL) peroxidase, we compared DNA content, SPF, G2/M + S, necrosis and apoptosis in non-recurrent and recurrent tumor cells of CP from 63 cases including 32 adamantine epitheliomas (AEs) and 31 squamous papillary tumors (SPTs), and the ultrastructure of the CP cell was observed by transmission electron microscopy. Although no... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3031636 Tue, 24 Nov 2009 07:10:55 +0100 3031636 http://www.medworm.com/index.php?rid=3019948&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp7742j71454827v8%2F Abstract  Breakthrough seizure activity has been reported with conversion from brand name to generic anticonvulsants. This has prompted several organizations to support physician notification of generic substitution and patient consent. Recently, a generic formulation of levetiracetam has become available. Risk of seizures with generic levetiracetam has yet to be reported. Literature was reviewed regarding risk of generic substitution. Four cases of seizure activity in primary brain tumor patients after conversion from Keppra to generic levetiracetam are reported. In all cases, there was no evidence of tumor growth or concurrent illness that would increase the risk of seizures. In three cases, the patients have remained seizure free with conversion back to Keppra. The final... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3019948 Sat, 21 Nov 2009 08:50:57 +0100 3019948 http://www.medworm.com/index.php?rid=3019949&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx02226h3163q426l%2F Abstract   Atypical Teratoid/Rhabdoid tumors (AT/RT) of the central nervous system are rare but aggressive tumors of childhood. Median survival with surgery and standard chemotherapy is less than 12 months. In an attempt to improve outcome, patients were treated with aggressive surgical resection and multi-agent chemotherapy, followed by high dose chemotherapy with autologous stem cell rescue. Nine consecutive children (median age 21 months) were diagnosed with AT/RT at the University of California San Francisco Childrens Hospital from 1997 to 2007 and treated with this aggressive approach. Diagnosis was confirmed using molecular markers. There are two long-term survivors (78 and 98 months from diagnosis). One additional patient is alive with disease. Three pa... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3019949 Sat, 21 Nov 2009 08:50:55 +0100 3019949 http://www.medworm.com/index.php?rid=3016030&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F12510351836g566h%2F Abstract  The authors describe a 9 month old female with recurrent atypical central neurocytoma and leptomeningeal spread treated with high dose chemotherapy, autologous stem cell rescue, and adjuvant therapy. She had a complete response to therapy and was disease free at 4 years of age until a recurrence 6 months later. The use of intensive chemotherapy followed by autologous stem cell rescue for atypical neurocytoma may be considered as an adjunct to surgical therapy in young patients with atypical neurocytoma not amenable to radiation therapy. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-0029-8Authors David Buchbinder, Children’s Hospital of Orange County Department of Pediatric Hematology 455 S. Main Street Orange CA 92868 U... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3016030 Thu, 19 Nov 2009 07:50:11 +0100 3016030 http://www.medworm.com/index.php?rid=3016031&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb002710qj9w64770%2F Abstract  The esthesioneuroblastoma is a rare neuroendocrine tumor that derives from the olfactory cells. In the last 20 years, around 1,000 cases have been described, with an overall survival rate of 60–70% at 5 years. The most common symptoms are nasal bleeding, nasal clogging and, in locally advanced cases, signs/symptoms of intracranic hypertension such as papilla edema, cefalea, and vomiting. The standard treatments are surgery and radiotherapy. Chemotherapy can be used in an adjuvant/neoadjuvant setting and in the metastatic phase, even if its role is still not established with certainty. Here, the case is reported of a young man (38 years old) with a locally advanced esthesioneuroblastoma. Two months before coming to our clinic, he had been treated e... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3016031 Wed, 18 Nov 2009 19:20:34 +0100 3016031 http://www.medworm.com/index.php?rid=3009554&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F12u5556185w861k6%2F In this study, we report that stimulation of DAOY with HGF resulted in the protection of these cells against etoposide-induced apoptosis, this anti-apoptotic effect being correlated with an increase in the expression of tissue factor (TF), the initiator of the extrinsic pathway of coagulation. HGF-mediated protection from apoptosis was abolished by a c-Met inhibitor as well as by siRNA-mediated reduction of TF levels, implying a central role of Met-dependent induction of TF expression in this process. Accordingly, stimulation of DAOY with FVIIa, the physiological ligand of TF, also resulted in a significant protection from etoposide-mediated cytotoxicity. Overall, our results suggest the participation of the haemostatic system to drug resistance in MB and may thus provide novel thera... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3009554 Wed, 18 Nov 2009 09:29:41 +0100 3009554 http://www.medworm.com/index.php?rid=3009555&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F325r15p5150p4286%2F In this study, we examined the effect of imatinib mesylate, a receptor tyrosine kinase inhibitor, on PNF-derived Schwann cells and PNF tumour growth in vitro and in vivo. In vitro, PNF-derived primary Schwann cells express platelet-derived growth factors receptors (PDGFR) α and β, both targets of imatinib, and cell viability was reduced by imatinib mesylate, with 50% inhibition concentration (IC50) of 10 μM. For in vivo studies, PNF tumour fragments xenografted onto the sciatic nerve of athymic nude mice were first characterized. The tumours persisted for at least 63 days and maintained typical characteristics of PNFs such as complex cellular composition, low proliferation rate and angiogenesis. A transient enlargement of the graft size was due to infl... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=3009555 Wed, 18 Nov 2009 05:13:17 +0100 3009555 http://www.medworm.com/index.php?rid=2993167&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F31061329qt66gt46%2F In this study we investigated the status of FOXO3a expression and related signaling in human glioma in order to test its potential value as a therapeutic target for this disease. Immunohistochemistry, western blot, RT-PCR, and immunofluorescence staining analysis were performed on specimens from 70 cases of human glioma and on U87MG and T98G glioma cells. Our data showed FOXO3a expression is directly correlated with the malignant grade of glioma. More importantly, low expression of FOXO3a was associated with poor patient outcome. In vitro, FOXO3a modulated the cell cycle by transcriptional regulation of p27kip1. Administration of the PI3K pharmacological inhibitor LY294002 abrogated this effect by regulating FOXO3a expression and subcellular localization. Our results suggested that F... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2993167 Fri, 13 Nov 2009 07:26:19 +0100 2993167 http://www.medworm.com/index.php?rid=2990234&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe223p7360162w606%2F Abstract  Medulloblastomas are highly malignant, poorly differentiated childhood tumours arising in the cerebellum. These tumors rarely lose TP53, which is the most commonly mutated gene in cancer. Recent work has shown that the basal level of p53 plays an important role in maternal reproduction by maintaining the expression of LIF in the uterus. Since LIF can maintain the undifferentiated state of stem cells we set out to ask if p53 regulates LIF in the human medulloblastoma cell lines DAOY and D283MED. We also used p53−/− and p53+/+ isogenic HCT116 colorectal carcinoma cell lines, already reported to exhibit p53-dependent expression of the LIF D transcript, to establish the extent of p53-dependency for LIF M and T alternative transcripts. Whilst all three known, ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2990234 Thu, 12 Nov 2009 07:18:52 +0100 2990234 http://www.medworm.com/index.php?rid=2986124&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm1162h5155750653%2F Abstract  Given the potential morbidity of whole brain radiation therapy (WBRT), there has been an increasing trend to defer WBRT and deliver Gamma Knife stereotactic radiosurgery (GKS) to cerebral metastatic lesions. We analyzed our experience delivering GKS to the tumor cavity following surgical resection of brain metastases and compared our results to patients receiving WBRT after surgical resection of a metastatic lesion. We performed a retrospective review of patients undergoing surgical resection of at least one brain metastasis between December 1999 and December 2008. Both univariate and multivariate Cox proportional hazards regression were utilized to analyze the influence of various prognostic factors on survival. Twenty-five patients had a metastatic lesion resect... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2986124 Wed, 11 Nov 2009 06:57:31 +0100 2986124 http://www.medworm.com/index.php?rid=2986123&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6475567402527411%2F We describe herein a surgically treated case of Lhermitte–Duclos disease in a 33-year-old man. The clinical presentation seemed typical in terms of symptoms, neurological signs, and neuroimaging. High and heterogenous fluorodeoxyglucose uptake in positron emission tomography study is presented and discussed. Furthermore, we performed volumetric analysis of the tumor with sequential magnetic resonance imaging over the course of 7 years before surgery, making this report the first with a long-term natural history, revealing that this rare disease entity may have a neoplastic nature. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-0042-yAuthors Yuko Goto, Osaka University Graduate School of Medicine Department of Neurosurgery Yamadaoka 2-2, E6 Suita Osak... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2986123 Wed, 11 Nov 2009 06:57:31 +0100 2986123 http://www.medworm.com/index.php?rid=2982350&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb497622274712886%2F Abstract  Matrix proteins are considered to be essential for biomineralization and to be important factors in cranioharyngioma calcification. Osteopontin (OPN) is a noncollagenous, acidic bone-matrix glycoprotein, which binds tightly to hydroxyapatite and appears to form an integral part of the mineralized matrix, probably important to the integrity of cell–matrix interactions. OPN is also a ligand for a cell membrane receptor, CD44v6, which is required for efficient OPN binding. To investigate the role of OPN in craniopharyngioma calcification formation, we studied the involvement of OPN and CD44v6 in craniopharyngiomas. Immunohistochemical staining was used in human craniopharyngiomas to detect the relationship of OPN and degree of calcification, and immunogold localiza... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2982350 Tue, 10 Nov 2009 08:09:44 +0100 2982350 http://www.medworm.com/index.php?rid=2974706&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0137843864g4j346%2F We report a case of primary leptomeningeal gliomatosis limited to the spinal cord occurring in a 52 years-old patient, who presented with back pain and leg weakness. MRI-scan of the craniospinal axis revealed an enhancing cervicothoracic lesion confined to the leptomeninges. A diagnostic biopsy was taken followed by a six level cervicothoracic laminoplasty with the aim of debulking of the dorsal portion of the tumour and relieving cord compression. Two weeks following surgery, the patient developed bilateral arm weakness. Repeat imaging revealed extension of the lesion to the level of the lower medulla. This patient underwent spinal radiotherapy and concomitant chemotherapy with Temozolomide, but she died of pneumonia 8.5 months after the time of diagnosis. No post-mortem w... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2974706 Sat, 07 Nov 2009 19:14:01 +0100 2974706 http://www.medworm.com/index.php?rid=2974707&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7624132h1854406j%2F Abstract  To characterize the overall survival (OS) and cause specific survival (CSS), and variables affecting outcome, in patients with primary spinal cord astrocytoma (SCA) and ependymoma (SCE). About 664 patients with SCA and 1,057 patients with SCE were analyzed using the Surveillance, Epidemiology, and End Results database. For grade 1, 2, 3 and 4 SCA, the 5-year OS was 82, 70, 28 and 14%; the 5-year CSS was 89, 77, 36 and 20%. For SCA, lower grade, younger age, and undergoing resection significantly improved OS and CSS; treatment without radiotherapy was favorable for CSS. Smaller tumor size also improved survival. For grade 1, 2, and 3 SCE, the 5-year OS was 92, 97 and 58%; the 5-year CSS was 100, 98 and 64%. For SCE, lower grade, younger age, and undergoing resectio... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2974707 Sat, 07 Nov 2009 07:44:59 +0100 2974707 http://www.medworm.com/index.php?rid=2974708&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn32607m373340186%2F Abstract  Extracranial metastasis of glioblastoma multiforme (GBM) is very rare, in spite of very aggressive tumor behavior and being documented in only a few patients. In this article we present a 25-year-old man with secondary glioblastoma associated with extracranial progression and distant metastasis. He was diagnosed by magnetic resononce (MR) with an intracranial lesion in the right parietofrontal region, which was subsequently resected. Histology revealed a diffuse astrocytoma (grade II). The tumor recurred 1 year later and the patient received a second craniotomy. A diagnosis of GBM was made. After radiotherapy, he presented with right cervical lymph node metastases. The cytomorphological features supported a diagnosis of metastatic glioblastoma multiforme. The... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2974708 Sat, 07 Nov 2009 07:44:58 +0100 2974708 http://www.medworm.com/index.php?rid=2974709&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw8n7ux2624104322%2F Abstract  Epithelioid Hemangioendothelioma (EH) is a rare soft-tissue tumor which may present as an isolated tumor or can spread to affect internal organs. The course of EH varies, based on the tissue of origin. This case report describes a young woman who developed cutaneous EH with concurrent intracranial disease during pregnancy. After resection, the lesions returned. Even after several courses of chemotherapy and radiotherapy, the patient developed multifocal disease including pulmonary, skeletal, and liver disease. She now exhibits stable disease after approximately 6 years of therapy with lenalidomide. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-0017-zAuthors Ashley Sumrall, University of Mississippi Medical Center Department of Oncology ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2974709 Sat, 07 Nov 2009 07:44:55 +0100 2974709 http://www.medworm.com/index.php?rid=2974710&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm10k3lk248701251%2F Abstract  A major obstacle in glioblastoma (GBM) therapy is the restrictive nature of the blood-brain barrier (BBB). Convection-enhanced delivery (CED) is a novel method of drug administration which allows direct parenchymal infusion of therapeutics, bypassing the BBB. MR1-1 is a novel recombinant immunotoxin that targets the GBM tumor-specific antigen EGFRvIII and can be delivered via CED infusion. However, drug distribution via CED varies dramatically, which necessitates active monitoring. Gadolinium conjugated to diethylenetriamine penta-acetic acid (Gd-DTPA) is a commonly used MRI contrast agent which can be co-infused with therapies using CED and may be useful in monitoring infusion leak and early distribution. Forty immunocompetent rats were implanted with intracerebr... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2974710 Sat, 07 Nov 2009 07:44:53 +0100 2974710 http://www.medworm.com/index.php?rid=2971438&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl89m14244678377g%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s11060-009-0048-5Authors Wael Hassaneen, The University of Texas, M. D. Anderson Cancer Center Houston TX USADaniel P. Cahill, The University of Texas, M. D. Anderson Cancer Center Houston TX USAGregory N. Fuller, The University of Texas, M. D. Anderson Cancer Center Houston TX USANicholas B. Levine, The University of Texas, M. D. Anderson Cancer Center Houston TX USA Journal Journal of Neuro-OncologyOnline ISSN 1573-7373Print ISSN 0167-594X (Source: Journal of Neuro-Oncology) Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2971438 Fri, 06 Nov 2009 06:53:27 +0100 2971438 http://www.medworm.com/index.php?rid=2968541&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp07804022q60v008%2F Abstract  Innovation in the management of brain metastases is needed. We evaluated the addition of compartmental intrathecal antibody-based radioimmunotherapy (cRIT) in patients with recurrent metastatic central nervous system (CNS) neuroblastoma following surgery, craniospinal irradiation, and chemotherapy. Twenty one patients treated for recurrent neuroblastoma metastatic to the CNS, received a cRIT-containing salvage regimen incorporating intrathecal 131I-monoclonal antibodies (MoAbs) targeting GD2 or B7H3 following surgery and radiation. Most patients also received outpatient craniospinal irradiation, 3F8/GMCSF immunotherapy, 13-cis-retinoic acid and oral temozolomide for systemic control. Seventeen of 21 cRIT-salvage patients are alive 7–74 months (median 33... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2968541 Thu, 05 Nov 2009 07:58:51 +0100 2968541 http://www.medworm.com/index.php?rid=2947837&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh64x08156275rh71%2F Abstract  Leptomeningeal dissemination of low-grade gliomas is an uncommon event. A 43-year old male presented with dizziness, gait ataxia, and diplopia. A nonenhancing lesion in the right cerebellar peduncle was identified, subtotally resected, and diagnosed as a grade II astrocytoma. After one year a nodular spread in the brain and leptomeninges was diagnosed, so the patient started chemotherapy with temozolomide and liposomal cytarabine. Complete remission was achieved after 12 months of treatment and the patient is still free from the disease after a follow-up of 24 months. We suggest that this combination may be a valuable treatment option. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-0040-0Authors Maria Grazia Passarin, USSL 22 ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2947837 Fri, 30 Oct 2009 07:49:38 +0100 2947837 http://www.medworm.com/index.php?rid=2944877&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6830w2u50v505484%2F Abstract  Ependymomas are glial neoplasms originating from the wall of the ventricles or from the spinal canal. The significance of histopathological features in accurately predicting biological behavior is still debated. Moreover, key molecular events in the pathogenesis of ependymoma are yet to be defined. The main objective of the present study was to identify specific patterns of chromosomal aberrations that correlate with tumor location, histological subtype and grade. Forty-five ependymoma samples were analyzed by 1-megabase resolution array comparative genomic hybridization (CGH). Association between clinical or histopathological parameters and the genomic alterations identified was evaluated. The most frequently detected chromosome (chr) abnormalities were gain of c... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2944877 Thu, 29 Oct 2009 07:22:22 +0100 2944877 http://www.medworm.com/index.php?rid=2940763&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm3k24728084848x5%2F In this study, we analyzed the effects of a 5-LO inhibitor, which inhibits the conversion of arachidonic acid to leukotrienes, on cell proliferation and apoptosis in human malignant glioma cells, including 5-LO-expressing cells U-87MG, A172 and 5-LO non-expressing cell U373. Growth of U-87MG and A172 cells, but not that of U373 cells, was inhibited in a dose-dependent manner by treatment with MK886. Similarly, specific 5-LO silencing by small interfering RNA reduced the growth of U-87MG and A172 cells. MK886 treatment reduced 5-LO activity independently of 5-LO-activating protein (FLAP) in human malignant glioma cells. MK886 treatment also induced cell apoptosis, measured by DNA fragmentation and nuclear condensation, in U-87MG and A172 cells but there were no signs in U373 cells. Mo... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2940763 Wed, 28 Oct 2009 07:16:00 +0100 2940763 http://www.medworm.com/index.php?rid=2936066&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4938685676217400%2F Abstract  The purpose of this study was to assess the usefulness of diffusion weighted imaging as an additional imaging biomarker for treatment response in recurrent/progressive malignant gliomas treated with bevacizumab alone or in combination with other chemotherapeutic agents. Twenty patients treated with bevacizumab alone or concurrent chemotherapy were followed up with serial MR imaging. Volume and ADC values of contrast enhancing lesion (CELvol, CELADC) and also of non-enhancing lesion (NELvol, NELADC) were obtained. CELvol showed a progressive decrease in non-progressors with a median percentage change of −73.2% (P = 0.001) as compared to −33.4% for progressors by 1 year/last imaging (P = 0.382). NELvol also showed a decrease in non-progressors o... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2936066 Mon, 26 Oct 2009 18:09:12 +0100 2936066 http://www.medworm.com/index.php?rid=2928292&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F66qt5v02833842vn%2F Abstract  Malignant gliomas—glioblastoma multiforme and anaplastic astrocytoma—are among the most fatal forms of cancer in humans. It has been suggested that hepatocyte growth factor (HGF) is a reliable predictor of glioma malignancy; amounts of HGF are directly related to cellular proliferation, angiogenesis, low apoptotic rate, and poor prognosis (WHO III and IV). We measured the HGF content of cerebrospinal fluid (CSF) from patients with malignant glioma glioblastoma multiforme (WHO IV; n = 14), anaplastic astrocytoma (WHO III; n = 4), and meningioma (WHO I; n = 9), and from control subjects (n = 25), and found a high concentration of HGF in patients with malignant glioma. However, CSF concentrations from glioblastoma multiforme ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2928292 Sun, 25 Oct 2009 06:59:10 +0100 2928292 http://www.medworm.com/index.php?rid=2928293&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpu1877m37331n45l%2F Abstract  Recent evidence supports the notion that transformation of undifferentiated neural stem cell (NSC) precursors may contribute to the development of glioblastoma multiforme (GBM). The over-expression and mutation of the epidermal growth factor receptor (EGFR), along with other cellular pathway mutations, plays a significant role in GBM maintenance progression. Though EGFR signaling is important in determining neural cell fate and conferring astrocyte differentiation, there is a limited understanding of its role in NSC and tumor stem cell (TSC) biology. We hypothesized that EGFR expression and mutation in post-natal NSCs may contribute to cellular aggressiveness including enhanced cellular proliferation, survival and migration. Stable subclones of C17.2 murine NSCs w... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2928293 Fri, 23 Oct 2009 18:43:31 +0100 2928293 http://www.medworm.com/index.php?rid=2913593&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F01873364r8l55334%2F Abstract  This retrospective series explores temozolomide monotherapy in elderly patients with primary CNS lymphoma (PCNSL) and severe comorbidities. In 17 patients (62–90 years old), the complete response rate was 47%, median progression-free survival was 5 months, and median overall survival was 21 months. Five of 17 patients (29.4%) had prolonged responses for at least 12 months and survived for more than 24 months. Three of these patients had a methylated O6-methylguanine-DNA methyltransferase (MGMT) promoter, while the MGMT status was not assessable in the remaining two patients. Temozolomide monotherapy appears to be effective in a subgroup of elderly PCNSL patients and deserves further evaluation. Content Type Journal ArticleCategory Clini... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2913593 Tue, 20 Oct 2009 16:25:28 +0100 2913593 http://www.medworm.com/index.php?rid=2913594&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy0663413l28j6325%2F Abstract  This multicenter study assesses the value of O6-methylguanine-DNA methyltransferase (MGMT) status for predicting overall survival in glioblastoma patients. Five methods are used, to identify the approach with the best prognostic value. Eighty-one tumors were obtained from patients with glioblastomas treated by surgery and radiotherapy with concomitant temozolomide (TMZ) followed by adjuvant TMZ. MGMT promoter methylation was assessed by qualitative methyl-specific polymerase chain reaction (MSP), semiquantitative methyl-specific polymerase chain reaction (SQ-MSP), and pyrosequencing, while MGMT expression was measured at the RNA level by quantitative real-time PCR (Q-RT-PCR) and at the protein level by immunohistochemistry (IHC). MGMT promoter methylation as evaluat... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2913594 Tue, 20 Oct 2009 16:25:27 +0100 2913594 http://www.medworm.com/index.php?rid=2905888&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx0r5667624253j38%2F Abstract  Bevacizumab and irinotecan are effective against recurrent malignant gliomas. However, at subsequent progression, patients rarely respond to a second bevacizumab-containing chemotherapeutic regimen. Salvage re-irradiation with bevacizumab for recurrent but bevacizumab naive malignant gliomas showed encouraging results. We performed a retrospective review of the medical records of 23 patients treated with either fractionated stereotactic radiotherapy (FSRT) or stereotactic radiosurgery (SRS) after progression on an initial bevacizumab regimen. Patients were treated after re-irradiation with bevacizumab but combined with a different chemotherapy. We then compared them to another 23 patients who progressed on an initial bevacizumab + chemotherapy regimen. T... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2905888 Fri, 16 Oct 2009 17:57:42 +0100 2905888 http://www.medworm.com/index.php?rid=2905889&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj0p044206405w417%2F Abstract  Tumefactive demyelinating lesions (TDLs) can mimic a neoplasm on conventional imaging and may necessitate biopsy for diagnosis. The purpose of this study was to differentiate TDLs from high grade gliomas based on physiologic (permeability) and hemodynamic (blood volume) parameters using perfusion CT. Five patients who presented with tumefactive enhancing lesions on initial MRI that mimicked a neoplasm underwent perfusion CT. We compared the perfusion CT parameters of these patients with those of 24 patients with high grade gliomas. TDLs showed lower permeability surface area product (PS) (0.8 ± 0.2 vs 2.4 ± 1.4 ml/100 g/min, P-value 0.014) and lower cerebral blood volume (CBV) (1.0 ± 0.2 vs 2.8 ± 1.2 ml/100... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2905889 Thu, 15 Oct 2009 06:13:11 +0100 2905889 http://www.medworm.com/index.php?rid=2887782&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj5155j7267w82306%2F We report the case of a woman with breast cancer and meningeal carcinomatosis who developed severe progressive myelopathy after four cycles of intrathecal MTX administration. We substituted high doses of the key metabolites of the methyl-transfer pathway: S-adenosylmethionine (SAM), 200 mg three times daily i.v.; folinate, 20 mg four times daily i.v.; cyanocobalamin, 100 μg once daily i.v.; and methionine, 5 g daily p.o. The patient’s paraparesis improved rapidly thereafter, and magnetic resonance (MR) imaging showed resolution of the intramedullary lesions. Genetic analyses revealed homozygosity for the A allele of methylenetetrahydrofolate reductase (MTHFR) c.1298A>C (p.E429A), whereas other genetic variants of folate/methionine metabolism associated with ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2887782 Sun, 11 Oct 2009 07:26:01 +0100 2887782 http://www.medworm.com/index.php?rid=2883844&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh864806g84h223w7%2F In conclusion, DI is a risk factor for complications when cisplatin and/or ifosfamide based protocols are used. The role of these agents in the management of ICGT should be carefully evaluated and guidelines for management of DI established. Content Type Journal ArticleCategory Clinical Study - Patient StudyDOI 10.1007/s11060-009-0033-zAuthors Samina Afzal, Hospital for Sick Children Division of Haematology/Oncology/Neuro-Oncology 555 University Avenue Toronto M5G 1X8 CanadaDiane Wherrett, Hospital for Sick Children Division of Endocrinology Toronto CanadaUte Bartels, Hospital for Sick Children Division of Haematology/Oncology/Neuro-Oncology 555 University Avenue Toronto M5G 1X8 CanadaUri Tabori, Hospital for Sick Children Division of Haematology/Oncology/Neuro-Oncology 555 Universi... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2883844 Sat, 10 Oct 2009 07:28:57 +0100 2883844 http://www.medworm.com/index.php?rid=2883846&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F83676w7xu28u6705%2F Abstract  Olfactory neuroblastoma (esthesioneuroblastoma) is a rare neoplasm of the olfactory epithelium in the upper nasal cavity. Here, we report the case of a 69-year-old man who presented with massive progression of a metastatic esthesioneuroblastoma after endonasal resection, functional neck dissection, and radiotherapy of local and distant tumor relapses. After exhaustion of all conventional therapeutic options, we initiated treatment with the oral multityrosinekinase inhibitor sunitinib mesylate. Using this drug, significant improvement of clinical symptoms, disease stabilization, and recovery from Karnofsky index of 40% to 70% could be achieved in the absence of significant adverse drug effects. The patient died 15 months after initiation of sunitinib therapy d... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2883846 Sat, 10 Oct 2009 07:28:56 +0100 2883846 http://www.medworm.com/index.php?rid=2883845&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg0176m6v46090k43%2F We describe a pilocytic astrocytoma of the CPA that was found to arise from the proximal portion of trigeminal nerve without any anatomic continuity with the brain stem and the cerebellum. Pre-operative MRI suggested a schwannoma. The proposed origin of this extremely rare tumor is the root entry zone of the involved nerve. The tumor was completely resected via a suboccipital retrosigmoid approach. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-0020-4Authors Formica Francesco, Università Politecnica delle Marche Clinica di Neurochirurgia v. Conca no 71 60020 Ancona ItalyIacoangeli Maurizio, Università Politecnica delle Marche Clinica di Neurochirurgia v. Conca no 71 60020 Ancona ItalyChiriatti Stefano, Università Politecnica delle Marche Clinica di Neuroc... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2883845 Sat, 10 Oct 2009 07:28:56 +0100 2883845 http://www.medworm.com/index.php?rid=2877443&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl6u11v561n225074%2F Abstract  Diffusion-weighted magnetic resonance imaging (DWI) is a sensitive imaging biomarker for tumor cellularity. Functional diffusion maps (fDMs), which examine voxel-by-voxel changes in the apparent diffusion coefficient (ADC) calculated from serial DWIs, have previously been applied to regions of contrast-enhancement; however, application of fDMs to non-enhancing brain tumors has not been pursued. In this case study we demonstrate the utility of applying fDMs to regions of abnormal FLAIR signal intensity in a patient diagnosed with gliomatosis cerebri: a relatively rare, infiltrative, non-enhancing brain tumor. The absolute volume of hypercellularity extracted from fDMs was useful in tracking tumor growth, which correlated in time with a progressive decline in neurol... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2877443 Thu, 08 Oct 2009 07:04:49 +0100 2877443 http://www.medworm.com/index.php?rid=2873310&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu118261471jx13u2%2F Abstract  Antibodies specifically targeting tumor-associated antigens have proved to be important tools in the treatment of human cancer. A desirable target antigen should be unique to tumor cells, abundantly expressed, and readily available for antibody binding. The Ku70/80 DNA-repair protein is expressed in the nucleus of most cells; it is, however, also present on the cell surface of tumor cell lines, and antibodies binding Ku70/80 at the cell surface were recently shown to internalize into tumor cells. To evaluate the potential of Ku70/80-antigen as a therapeutic target for immunotoxins in glioblastoma multiforme, we investigated binding and localization of Ku70/80-specific antibodies in tissue samples from glioblastomas and normal human brains, and in glioma cell cultu... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2873310 Wed, 07 Oct 2009 06:59:00 +0100 2873310 http://www.medworm.com/index.php?rid=2870077&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr41k251n67755545%2F In conclusion, GS is a very rare tumor entity in children. Literature review suggests a relatively higher incidence in infants and in patients with a previous history of radiotherapy. Content Type Journal ArticleCategory Clinical Study - Patient StudyDOI 10.1007/s11060-009-0021-3Authors Michael Karremann, Martin Luther University Halle-Wittenberg Department of Pediatrics and Adolescence Medicine Halle GermanyUlrike Rausche, Martin Luther University Halle-Wittenberg Department of Pediatrics and Adolescence Medicine Halle GermanyGudrun Fleischhack, University Hospital Bonn Department of Pediatrics Bonn GermanyMichaela Nathrath, Technische Universität München Department of Pediatrics Munich GermanyTorsten Pietsch, University of Bonn Institute of Neuropathology Bonn GermanyChristof M. ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2870077 Tue, 06 Oct 2009 12:42:26 +0100 2870077 http://www.medworm.com/index.php?rid=2870076&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2746042453624274%2F This study supports the rationale for developing SIP1 as a potential therapeutic and diagnostic target for gliomas. Content Type Journal ArticleCategory Laboratory Investigation - Human/Animal TissueDOI 10.1007/s11060-009-0015-1Authors Microgene Xia, The University of Hong Kong Integrative Laboratory Pokfulam, Hong Kong ChinaMinghua Hu, Yijishan Hospital, Wannan Medical College Wuhu 241001 ChinaJun Wang, Yijishan Hospital, Wannan Medical College Wuhu 241001 ChinaYajun Xu, Yijishan Hospital, Wannan Medical College Wuhu 241001 ChinaXiaobing Chen, Henan Tumor Hospital Department of Internal Medicine Zhengzhou 450008 ChinaYuedong Ma, The First Affiliated Hospital of Sun Yat-sen University Department of Internal Medicine Guangzhou 510080 ChinaLei Su, The First Affiliated Hospital of Sun Y... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2870076 Tue, 06 Oct 2009 12:42:26 +0100 2870076 http://www.medworm.com/index.php?rid=2870078&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhu572002mr770725%2F In this study, C/EBPδ immunohistochemical expression was assessed in 49 meningiomas of different histotype and grade and correlated with a variety of clinico-pathological data and with the overall and recurrence-free survival of the patients. Positive staining was observed in the nuclei of neoplastic cells in 22 out of the 49 cases analyzed. C/EBPδ expression was significantly associated with a low histological grade and proliferation index, reflected by low Ki-67 labeling index (LI) and mitotic activity, and with the presence of intra-tumoral inflammatory infiltrate and the absence of necrosis. In addition, the absence of C/EBPδ was significantly correlated with a shorter disease-free interval. Our findings suggest that C/EBPδ expression may prevent the development of recurrenc... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2870078 Tue, 06 Oct 2009 12:42:25 +0100 2870078 http://www.medworm.com/index.php?rid=2870079&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F133u2213n8602064%2F Abstract  Merkel cell carcinoma (MCC) is a malignant neuroendocrine tumor of the skin that demonstrates a remarkable tendency to metastasize. However, only a few cases of MCC brain metastases have been reported in the literature. We here present a unique case of a pituitary metastasis of MCC in a 65-year-old patient with a history of pituitary adenoma. This case is particularly novel due to the fact that the primary site of the MCC is unknown. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-0025-zAuthors Alberto Feletti, University of Padova Department of Neurosurgery, Treviso Hospital Piazzale Ospedale, 1 31100 Treviso ItalyElisabetta Marton, University of Padova Department of Neurosurgery, Treviso Hospital Piazzale Ospedale, 1 31100 Treviso ItalyS... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2870079 Tue, 06 Oct 2009 12:42:24 +0100 2870079 http://www.medworm.com/index.php?rid=2863537&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff8q6268350210r75%2F Abstract  We prospectively analyzed the safety and outcome of frameless image-guided robotic stereotactic radiosurgery (SRS) for treatment of brain metastases in patients that would have otherwise been treated with frame-based techniques. During a three-year period, 333 patients with 783 brain metastases of various histologies underwent 391 outpatient SRS procedures. Fifty-five percent of patients had multiple brain metastases. The median (mean) tumor volume was 1.0 cc (2.7 cc). The mean prescribed tumor dose was 18.5 Gy (±1.3 Gy). Local/distant tumor recurrences were treated by additional SRS for patients with stable systemic disease. Survival and freedom from local tumor recurrence was analyzed with the Kaplan–Meier method. Prognostic factors were ob... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2863537 Sun, 04 Oct 2009 05:43:25 +0100 2863537 http://www.medworm.com/index.php?rid=2863538&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7156161262821n7k%2F Abstract  Adults diagnosed with Glioblastoma multiforme (GBM) are frequently faced with a 7% chance of surviving 2 years compared with pediatric patients with GBM who have a 26% survival rate. Our recent screen of possible glioma-associated antigen precursor protein (TAPP) profiles displayed from different types of pediatric brain tumors showed that pediatric patients contained a subset of the tumor antigens displayed by adult GBM patients. Adult GBM possess at least 27 tumor antigens that can potentially stimulate T cell immune responses, suggesting that these tumors are quite antigenic. In contrast, pediatric brain tumors only expressed nine tumor antigens with mRNA levels that were equivalent to those displayed by adult GBM. These tumor-associated antigens could be ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2863538 Sun, 04 Oct 2009 05:43:24 +0100 2863538 http://www.medworm.com/index.php?rid=2863539&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F83jq514674434267%2F Abstract  CD4+/CD56+ hematodermic neoplasm, formerly known as blastic NK-cell lymphoma, is an uncommon, aggressive non-Hodgkin’s lymphoma with cutaneous, lymph node, and bone marrow involvement at presentation. The disease is characterized by early leukemic phase; however, central nervous system involvement is rarely reported. Herein we describe two cases of CD4+/CD56+ hematodermic neoplasm with meningeal manifestation. Microscopic analysis and flow cytometry of cerebrospinal fluid proved to be diagnostic; however, imaging studies were not informative. These observations call attention to the possibility of central nervous system involvement, which could be more common than expected previously. Authors recommend routine cerebrospinal fluid analysis and prophylactic intrat... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2863539 Fri, 02 Oct 2009 05:49:17 +0100 2863539 http://www.medworm.com/index.php?rid=2863540&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fdp7063344304012t%2F Abstract  Paraneoplastic cerebellar degeneration is a rare neurological disorder that frequently precedes the detection of malignancy. Here, we report the case of a 60 year-old woman with locally advanced squamous cell carcinoma of the tongue who developed a subacute cerebellar syndrome associated with the presence of anti-CV2/CRMP5 antibodies in the cerebrospinal fluid, after achieving complete remission of the primary tumor and the involved cervical lymph nodes by chemoradiation. The patient’s symptoms on presentation were dizziness and gait unsteadiness. On examination she showed dysarthria, nystagmus and limb and gait ataxia. The diagnosis of paraneoplastic cerebellar syndrome was made on the basis of the clinical findings and immunological testing that revealed ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2863540 Thu, 01 Oct 2009 18:16:30 +0100 2863540 http://www.medworm.com/index.php?rid=2856505&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkp7527l774658040%2F We present an unusual case report of a patient with Graves’ disease and no previous history of lymphoma, who was found to have bilateral orbital mantle cell lymphoma on CT and MR imaging which was confirmed histopathologically. To our knowledge, there have been no previously described cases of bilateral mantle cell lymphoma in Graves’ disease. Of particular radiologic interest, the left orbital mass presented in a bicompartmental fashion with a discreet intraconal component separated by a fat plane from an extraconal component that extended intraconally. In our review of radiologic literature, this presentation has not been described previously. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-0019-xAuthors Asif Abdullah, University of Toledo Medical Cen... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2856505 Wed, 30 Sep 2009 18:27:59 +0100 2856505 http://www.medworm.com/index.php?rid=2839830&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq771vw6541k34541%2F Abstract  Medulloblastomas (MB) and primitive neuroectodermal tumors (PNET) are the most common malignant brain tumors in children. These two tumor types are histologically similar, but have different genetic backgrounds and clinical outcomes. Other brain tumors, such as gliomas, frequently have coamplification and overexpression of receptor tyrosine kinases KIT, platelet-derived growth factor receptor alpha (PDGFRA), and vascular endothelial growth factor receptor 2 (VEGFR2). We investigated protein expression and gene copy numbers of KIT, PDGFRA, and VEGFR2 in 41 MB and 11 PNET samples by immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH). KIT and PDGFRA expression was detected in both MBs and PNETs, whereas VEGFR2 expression was weak in these tu... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2839830 Fri, 25 Sep 2009 05:48:24 +0100 2839830 http://www.medworm.com/index.php?rid=2833066&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff76573260821mw07%2F In this study, Notch1 overexpression was observed in the majority of 45 astrocytic gliomas with different grades and in U251MG glioma cells. Transfection of siRNA targeting Notch1 into U251 cells in vitro downregulated Notch1 expression, associated with inhibition of cell growth, arrest of cell cycle, reduction of cell invasiveness, and induction of cell apoptosis. Meanwhile, tumor growth was delayed in established subcutaneous gliomas in nude mice treated with Notch1 siRNA in vivo. These results suggest that Notch1 plays an important oncogenic role in the development and progression of astrocytic gliomas. Furthermore, knockdown of Notch1 expression by siRNA simultaneously downregulated the expression of EGFR and the important components of its downstream pathways, including PI3K, p... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2833066 Tue, 22 Sep 2009 15:41:51 +0100 2833066 http://www.medworm.com/index.php?rid=2825699&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffr67p4u653832600%2F The objective of the present study was to investigate the interest of convection-enhanced delivery (CED) for the administration of a nanocarrier-based radiosensitizing chemotherapy in the rat brain. Pursuing on newly developed lipid nanocapsules (LNC) that can be internalised within brain tumour cells, we studied their intracerebral distribution when labelled with fluorescent Nile red (NR). As paclitaxel (Px) represents an interesting radiosensitiser, we also evaluated the potential radiosensitising effects of Px-loaded LNC administered through CED in the 9L intracranial rat glioblastoma model. The distribution study demonstrated that CED injection of NR-loaded LNC (NR-LNC) improved significantly the volume of distribution of NR when matched with simple injection (by about 150 fold).... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2825699 Mon, 21 Sep 2009 05:31:40 +0100 2825699 http://www.medworm.com/index.php?rid=2815705&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F36134143x4042v12%2F Abstract  High risk/recurrent CNS tumors have a poor prognosis. We studied tandem high dose chemotherapy (HDC) with hematopoietic progenitor stem cell rescues (HPCR) as potentially curative therapy. Twenty-four patients (mean age 6.8 years) were enrolled, 19 underwent HDC/HPCR. Diagnoses were medulloblastoma (n = 9), germ cell tumor (n = 4), high grade astrocytoma (n = 2), supratentorial PNET (n = 1), pineoblastoma (n = 2), or papillary meningioma (n = 1). Cytoreduction regimen #1 consisted of carboplatin (500 mg/m2) × 3 days, etoposide (250 mg/m2) × 3 days, and thiotepa (300 mg/m2) × 3 days. Patients without progression or excessive toxicity (n = 11), received ... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2815705 Sun, 20 Sep 2009 15:32:40 +0100 2815705 http://www.medworm.com/index.php?rid=2815706&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0u047l05m175810w%2F Abstract  TNF-related apoptosis-inducing ligand (TRAIL), a promising novel anti-cancer cytokine of the TNF superfamily, and Bortezomib, the first-in-class clinically used proteasome inhibitor, alone or in combination have been shown to efficiently kill numerous tumor cell lines. However, data concerning primary human tumor cells are very rare. Using primary esthesioneuroblastoma cells we analyzed the anti-tumor potential and the mechanism employed by Bortezomib in combination with TRAIL for the treatment of this rare but aggressive tumor. Expression of components of the TRAIL pathway was analyzed in tumor specimens and isolated primary tumor cells at the protein level. Cells were treated with TRAIL, Bortezomib, and a combination thereof, and apoptosis induction was quantifi... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2815706 Sun, 20 Sep 2009 05:38:04 +0100 2815706 http://www.medworm.com/index.php?rid=2815707&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhj83107306h2m247%2F Abstract  Imatinib, an orally administered tyrosine kinase inhibitor of PDGF receptor, c-abl and c-kit, is currently in clinical trials to assess its efficacy in malignant gliomas. Although imatinib does not readily penetrate an intact blood–brain barrier (BBB), the extent to which it distributes into regions of high grade gliomas where the BBB is compromised has not been determined. Patients with recurrent high-grade gliomas for whom repeat surgical tumor debulking was clinically indicated received imatinib mesylate 600 mg orally once a day for seven days prior to surgery. Tissue samples were collected from different regions of the tumor and the approximate location of these samples was determined using frameless stereotactic neuronavigation. Plasma samples were obt... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2815707 Sat, 19 Sep 2009 05:51:58 +0100 2815707 http://www.medworm.com/index.php?rid=2810599&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa361201371171480%2F Abstract  Although their neurocognitive performance is one of the major concerns of patients with high-grade gliomas (HGG) and although neurocognitive deficits have been described to be associated with negative outcome, neurocognitive rehabilitation is usually not integrated into the routine care of patients with malignant gliomas. In this pilot trial, a weekly group training session for attention, verbal, and memory skills was offered to patients with HGG with pre and post-training evaluation. Eleven patients, six with glioblastoma multiforme and five with WHO grade III gliomas, median age 50 years, with a Karnofsky performance score of 80–100 participated in ten group training sessions of 90 min. For evaluation at baseline and after the training by a neuropsych... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2810599 Thu, 17 Sep 2009 23:33:24 +0100 2810599 http://www.medworm.com/index.php?rid=2810600&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnw4q57k503p24371%2F In conclusion, among the five platinum compounds tested, carboplatin and LipoplatinTM showed the best radiosensitizing effect. LipoplatinTM seems the most promising since it led to the best cellular incorporation and has already been reported to be less neurotoxic than other platinum compounds. Content Type Journal ArticleCategory Laboratory Investigation - Human/Animal TissueDOI 10.1007/s11060-009-0011-5Authors Gabriel Charest, Université de Sherbrooke Sherbrooke CanadaBenoit Paquette, Université de Sherbrooke Sherbrooke CanadaDavid Fortin, Université de Sherbrooke Sherbrooke CanadaDavid Mathieu, Université de Sherbrooke Sherbrooke CanadaLéon Sanche, Université de Sherbrooke Sherbrooke Canada Journal Journal of Neuro-OncologyOnline ISSN 1573-7373Print ISSN 0167-594X (S... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2810600 Thu, 17 Sep 2009 12:19:55 +0100 2810600 http://www.medworm.com/index.php?rid=2767167&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4773862265706661%2F We present the unusual case of a breast cancer patient who developed a solitary choroid plexus metastasis in the left lateral ventricle. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-9988-zAuthors Alessandro Della Puppa, Padua University Hospital Department of Neurosurgery Via Giustiniani 2, Azienda Ospedaliera di Padova 35128 Padua ItalySandro Dal Pos, Padua University Hospital Department of Neuro-Radiology Padua ItalyStefania Zovato, IOV IRCCS of Padua Department of Oncology Padua ItalyEnrico Orvieto, Padua University Hospital Department of Pathology Padua ItalyPietro Ciccarino, Padua University Hospital Department of Neurosurgery Via Giustiniani 2, Azienda Ospedaliera di Padova 35128 Padua ItalyRenzo Manara, Padua University Hospital Department of Neuro-Ra... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2767167 Thu, 03 Sep 2009 06:14:33 +0100 2767167 http://www.medworm.com/index.php?rid=2767166&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc03g273823p6720r%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s11060-009-9999-9Authors Debraj Mukherjee, Neuro-Oncology Surgical Outcomes Research Laboratory Department of Neurosurgery and Oncology 1550 Orleans Street, Cancer Research Building II Room 253 Baltimore MD 21231 USADavid C. Chang, Neuro-Oncology Surgical Outcomes Research Laboratory Department of Surgery 1550 Orleans Street, Cancer Research Building II Room 253 Baltimore MD 21231 USAAlfredo Quiñones-Hinojosa, Neuro-Oncology Surgical Outcomes Research Laboratory Department of Neurosurgery and Oncology 1550 Orleans Street, Cancer Research Building II Room 253 Baltimore MD 21231 USA Journal Journal of Neuro-OncologyOnline ISSN 1573-7373Print ISSN 0167-594X (Source: Journal of Neuro-Oncology) Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2767166 Thu, 03 Sep 2009 06:14:33 +0100 2767166 http://www.medworm.com/index.php?rid=2767168&cid=s_33361_6_f&fid=33361&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F41v91264m7315572%2F Abstract  The aim of our study was to evaluate the role of proton magnetic resonance (MR) spectroscopy and MR perfusion in the follow-up of low-grade gliomas, since conventional MR imaging (MRI) is not reliable in detecting the passage from a low- to high-grade tumor. Twenty-one patients with a World Health Organisation (WHO) grade II glioma were followed up using proton MR spectroscopy, perfusion, and conventional MRIs. Follow-up MRIs had been performed at the third month of evolution and then twice a year, with an average of five MR studies per patient. Five out of the 21 patients had an anaplastic transformation. A choline to creatine ratio (choline/creatine ratio) above 2.4 is associated with an 83% risk of a malignant transformation in an average delay of 15.4&nbs... Journal of Neuro-Oncology journals http://www.medworm.com/rss/comments.php?id=2767168 Thu, 03 Sep 2009 06:14:32 +0100 2767168