Journal of Oral Pathology and Medicine via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Oral Pathology and Medicine' source. Thu, 09 Feb 2012 00:42:17 +0100 Cancer‐associated fibroblasts and CD163‐positive macrophages in oral squamous cell carcinoma: their clinicopathological and prognostic significance http://www.medworm.com/index.php?rid=5651006&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2012.01127.x Conclusions:  Cancer‐associated fibroblasts and CD163‐positive macrophages may be potential prognostic predictors of OSCC. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5651006 Wed, 01 Feb 2012 05:00:00 +0100 5651006 Evaluation of mast cells in periapical cysts, dentigerous cysts, and keratocystic odontogenic tumors http://www.medworm.com/index.php?rid=5639867&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2012.01126.x Conclusions:  Immunohistochemical staining detected higher number of mast cells than histochemistry. The higher number of mast cells observed in inflamed lesions could indicate the participation of these cells in the inflammatory response in odontogenic lesions. The prevalence of degranulated mast cells in the deep region suggests intense activity of these cells, possibly related to growth of cystic lesions. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5639867 Fri, 27 Jan 2012 05:00:00 +0100 5639867 Binary system of grading oral epithelial dysplasia: evidence of a bearing to the scores of an immunohistochemical study http://www.medworm.com/index.php?rid=5639866&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2012.01128.x (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5639866 Sun, 01 Jan 2012 05:00:00 +0100 5639866 Bisphosphonate‐induced osteonecrosis of the jaw in a rat model arises first after the bone has become exposed. No primary necrosis in unexposed bone http://www.medworm.com/index.php?rid=5621573&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01125.x Conclusion:  Bisphosphonates and dexamethasone caused no osteocyte death in uninjured bone, but large ONJ‐like lesions after tooth extraction. Osteonecrosis of the jaw appears to arise first after the bone has been exposed. Possibly, bisphosphonates hamper the necessary resorption of bone that has become altered because of infection. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5621573 Sun, 01 Jan 2012 05:00:00 +0100 5621573 The effects of heparan sulphate mimetic RGTA‐OTR4120 on irradiated murine salivary glands http://www.medworm.com/index.php?rid=5585643&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01124.x Conclusion:  RGTA‐OTR4120 administration has a positive effect on salivary flow rates in irradiated mice on the short term. The effect was absent 10 weeks after radiotherapy, while at that time point, mucin producing activity of acinar cells was elevated by RGTA‐OTR4120 administration. Given these results and the advantages of RGTA use in irradiated patients, further investigation on the potential of this drug to treat radiation‐induced salivary gland damage, alone or in combination with other drugs, such as amifostine, is suggested. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5585643 Sun, 01 Jan 2012 05:00:00 +0100 5585643 Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis http://www.medworm.com/index.php?rid=5527628&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01122.x Conclusion:  We conclude that there is a significant association of deficiency of hemoglobin, iron and vitamin B12, abnormally high blood homocysteine level, and serum GPCA positivity with AG. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5527628 Thu, 22 Dec 2011 05:00:00 +0100 5527628 Current trends in miRNAs and their relationship with oral squamous cell carcinoma http://www.medworm.com/index.php?rid=5527629&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01121.x J Oral Pathol Med (2011)A micro RNA (miRNA) is a single‐stranded endogenous, non‐coding RNA, with length ranging between 18 and 24 nucleotides and the ability of regulating the expression of other genes on a post‐transcriptional level by means of various processes, degradation or repression of target mRNA. miRNAs play a crucial role in regulating fundamental processes such as cell cycle, differentiation and apoptosis; thus, their deregulation can affect normal cell growth and development, and even participate in carcinogenesis. The goals of this paper are: to outline the formation and functions of miRNAs; to determine their role in oral squamous cell carcinoma; to analyze the different miRNAs described and their roles as oncogenes or tumor suppressor genes, depending on their overexp... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5527629 Wed, 21 Dec 2011 05:00:00 +0100 5527629 The chemoadjuvant potential of grape seed procyanidins on p53‐related cell death in oral cancer cells http://www.medworm.com/index.php?rid=5433464&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01103.x Conclusion:  Antiproliferative effectiveness of GSP is closely associated with the p53 status of OSCC cells. GSP displays chemoadjuvant potential via cell cycle blockage and apoptotic induction. Our findings clearly suggest that GSP may play a role as a novel chemopreventive or therapeutic agent for OSCC. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5433464 Mon, 21 Nov 2011 05:00:00 +0100 5433464 Randomized trials for the treatment of burning mouth syndrome: an evidence‐based review of the literature http://www.medworm.com/index.php?rid=5424235&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01100.x J Oral Pathol Med (2011)Burning mouth syndrome (BMS) is defined as a chronic pain condition, characterized symptomatically by a generalized or localized burning sensation in the oral cavity. Various drugs have been used in attempting to treat BMS, but there is insufficient evidence to show the effect of any effective treatment. The aim of this review was to assess the effectiveness of therapies for BMS. Randomized controlled trials (RCTs) enrolling patients with a diagnosis of BMS were identified by searching Pubmed and Scoppus databases. The methodological quality of included studies was assessed on the basis of the method of allocation concealment, blindness of the study, loss of participants, size sample, and outcome concealment. A total of 12 relevant articles were analyzed. Therapies ... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5424235 Fri, 18 Nov 2011 05:00:00 +0100 5424235 Neurolytic effects of ampicillin on the rat infraorbital nerve http://www.medworm.com/index.php?rid=5424234&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01098.x Conclusion:  Ampicillin can cause peripheral nerve damage when injected perineurally. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5424234 Fri, 18 Nov 2011 05:00:00 +0100 5424234 Immunohistochemical expression of Rho GTPases in ameloblastomas http://www.medworm.com/index.php?rid=5424233&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01108.x J Oral Pathol Med (2011)Rho GTPases are proteins that regulate cell cycle, shape, polarization, invasion, migration, and apoptosis, which are important characteristics of normal and neoplastic cells. Rho GTPases expression has been reported in normal tooth germ and several pathologies; however, it has not been evaluated in ameloblastomas. The aim of this study was to analyze the expression and distribution of RhoA, RhoB, Rac1, and Cdc42 Rho GTPases in solid and unicystic ameloblastomas. Three‐micrometer sections from paraffin‐embedded specimens were evaluated by using an avidin–biotin immunohistochemical method with antibodies against the proteins mentioned above. RhoA and RhoB staining was observed in a high number of cells (P < 0.05) and greater intensity in non‐polarized ... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5424233 Fri, 18 Nov 2011 05:00:00 +0100 5424233 Non‐syndromic multiple supernumerary teeth: meta‐analysis http://www.medworm.com/index.php?rid=5424232&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01111.x Conclusion:  Although NSMST is a condition that has a higher incidence in the male gender, no differences have been found as to their number and localization in both genders. Bilaterality seems to be a common characteristic of this disorder. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5424232 Fri, 18 Nov 2011 05:00:00 +0100 5424232 The importance of stromal inflammation in squamous cell carcinoma of the tongue http://www.medworm.com/index.php?rid=5411495&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01107.x Conclusions:  Data clearly showed that tongue tumours have a split invasive growth pattern and an intense inflammatory response at the tumour interface. Results also indicated that evaluation of the intensity of the inflammatory infiltrate at the tumour interface in tongue SCC could provide information of potential importance for choice of treatment and prognosis. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411495 Wed, 16 Nov 2011 05:00:00 +0100 5411495 Clinicopathological evaluation of carcinoma cuniculatum: a variant of oral squamous cell carcinoma http://www.medworm.com/index.php?rid=5411494&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01116.x J Oral Pathol Med (2011)Carcinoma cuniculatum (CC) is a rare neoplasm of oral squamous cell carcinoma (OSCC) and remains a histopathological challenge to pathologists because of its low incidence and unique architecture. Therefore, the purpose of this study was to illustrate the clinicopathological findings and biological behavior about this distinctive lesion. Clinical and follow‐up information were retrieved from medical charts, and histopathological analyses were performed. Our series included 15 cases of CC, and the study included seven men and eight women, age 44–92. The tongue and mandible were the most frequently affected sites. There were three lymph node metastasis cases, and three local recurrences; one of the patients died of lung metastasis from oral CC. Histopathologically... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411494 Wed, 16 Nov 2011 05:00:00 +0100 5411494 Histopathological features that predict the recurrence of odontogenic keratocysts http://www.medworm.com/index.php?rid=5411493&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01113.x Conclusion:  In this case series, several differences were found in relation to histological features of recurring and non‐recurring OKCs. There are many factors responsible for the high recurrence rate of OKCs, and the presence of subepithelial hyalinisation may be used as an additional histopathological feature to predict a greater tendency for recurrence. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411493 Wed, 16 Nov 2011 05:00:00 +0100 5411493 Topical pimecrolimus effect on Fas inducing apoptosis in oral lichen planus: a clinical immunohistochemical study http://www.medworm.com/index.php?rid=5411492&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01099.x Conclusions:  Topical pimecrolimus reduced Fas expression, and it appears to be a promising alternative treatment for OLP. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411492 Wed, 16 Nov 2011 05:00:00 +0100 5411492 Oral neurovascular hamartoma: a lesion searching for a name http://www.medworm.com/index.php?rid=5411491&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01101.x Conclusion:  Oral NVH may not be as rare as previously considered. Morphometric analysis demonstrated that NVH presents a separate distinct entity. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411491 Wed, 16 Nov 2011 05:00:00 +0100 5411491 Differential activation of proapoptotic molecules between mouse and rat models of distal motor trigeminal denervation http://www.medworm.com/index.php?rid=5411490&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01109.x Conclusions:  Our findings indicate differential activation of motor neuron apoptosis pathways after axotomy in mice and rats. Lack of activation of caspase‐independent pathways and distal end denervation in our model might be related to the survival of motor neurons after axonal injury. These findings could be relevant to future neuroprotective strategies for peripheral nerve injury caused by oral surgeries. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411490 Wed, 16 Nov 2011 05:00:00 +0100 5411490 Prognostic significance of matrix metalloproteinase‐2, ‐8, ‐9, and ‐13 in oral tongue cancer http://www.medworm.com/index.php?rid=5411488&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01110.x Conclusion:  Our results suggest that especially MMP‐13 may be regarded as a prognostic biomarker in OTSCC. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411488 Wed, 16 Nov 2011 05:00:00 +0100 5411488 Association of XRCC1, XRCC3, and NAT2 polymorphisms with the risk of oral submucous fibrosis among eastern Indian population http://www.medworm.com/index.php?rid=5411487&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01097.x Conclusion:  Gene–gene interaction analysis by multifactor dimensionality reduction (MDR) revealed that XRCC3 Thr 241 Met had the largest univariate effect followed by XRCC3 Thr 241 Met – NAT2 A857G in men that presents a highly synergistic interaction as one of the potential combinations of single nucleotide polymorphisms (SNPs) to increase the risk of OSF in men if exposed to arecanut or smokeless tobacco usage. These observations can speculate the impact of the studied SNPs on the etiology of OSF. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411487 Wed, 16 Nov 2011 05:00:00 +0100 5411487 Cancer stem‐like cells in adenoid cystic carcinoma of salivary glands: relationship with morphogenesis of histological variants http://www.medworm.com/index.php?rid=5411486&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01096.x Conclusion:  It is suggested that CSCs included in CD133‐ or CD44‐positive cells play an important role in morphogenesis of salivary AdCC, especially in transition among the histological growth patterns. ECM is well known as a component of the CSC microenvironment, and ECM may regulate morphogenesis of AdCC through the stimulation of CSCs. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411486 Wed, 16 Nov 2011 05:00:00 +0100 5411486 Oral sampling and human papillomavirus genotyping in HIV‐infected patients http://www.medworm.com/index.php?rid=5411498&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01093.x Conclusion:  Sampling is a significant factor for oral prevalence studies. Oral rinse provides the best representation for HPV in the oral cavity. To evaluate associated cofactors other than receptive oral sex, larger studies with case–control design are necessary. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411498 Tue, 15 Nov 2011 05:00:00 +0100 5411498 Loss of heterozygosity (LOH) in tumour suppressor genes in benign and malignant mixed odontogenic tumours http://www.medworm.com/index.php?rid=5411497&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01115.x In conclusion, our results show a higher FAL in AFS compared to its benign counterparts and reveal a different pattern of LOH of tumour suppressor genes in AFS, which may regulate changes in tumour behaviour. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411497 Tue, 15 Nov 2011 05:00:00 +0100 5411497 Altered redox homeostasis in human diabetes saliva http://www.medworm.com/index.php?rid=5411504&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01092.x Conclusion:  DM is associated with increased oxidative modification of salivary DNA and proteins. Salivary redox homeostasis is perturbed in DM and may inform on the presence of the disease and efficacy of therapeutic interventions. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411504 Mon, 14 Nov 2011 05:00:00 +0100 5411504 The antimicrobial effect of Iseganan HCl oral solution in patients receiving stomatotoxic chemotherapy: analysis from a multicenter, double‐blind, placebo‐controlled, randomized, phase III clinical trial http://www.medworm.com/index.php?rid=5411502&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01094.x Conclusions:  Topical Iseganan HCl significantly reduces the total oral aerobic bacterial, streptococcal, and yeast load. Its potential as an oral antimicrobial agent in preventing these types of infections is clear. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411502 Mon, 14 Nov 2011 05:00:00 +0100 5411502 Differential expression of canonical and non‐canonical Wnt ligands in ameloblastoma http://www.medworm.com/index.php?rid=5411501&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01104.x Conclusion:  Differential expression of Wnt ligands in different ameloblastoma subtypes suggests that the canonical and non‐canonical Wnt pathways are selectively activated or repressed depending on the tumor cell differentiation status. Canonical Wnt pathway is most likely the main transduction pathway while Wnt‐1 might be the key signaling molecule involved in ameloblastoma tumorigenesis. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411501 Mon, 14 Nov 2011 05:00:00 +0100 5411501 Reappraisal of KIT mutation in adenoid cystic carcinomas of the salivary gland http://www.medworm.com/index.php?rid=5411500&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01105.x Conclusion:  This study supports that mutational study using paraffin‐embedded tissue should be interpreted with great caution. KIT gene mutation is very rare in ACC, and gene mutation is not the cause of protein overexpression. KIT protein expression may have a potential value for better prognostic factor in patients with metastasis. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411500 Mon, 14 Nov 2011 05:00:00 +0100 5411500 Dental erosion and salivary flow rate in cerebral palsy individuals with gastroesophageal reflux http://www.medworm.com/index.php?rid=5411499&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01112.x Conclusion:  The presence of GERD contributes significantly to dental erosion in the most compromised individuals with quadriplegics cerebral palsy individuals, increasing the risk of oral disease in this population. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411499 Mon, 14 Nov 2011 05:00:00 +0100 5411499 Effect of stressful life events on the onset and duration of recurrent aphthous stomatitis http://www.medworm.com/index.php?rid=5401988&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01102.x Conclusions:  In patients with a history of RAS, stressful events may mediate changes involved in the initiation of new RAS episodes. Mental stressors are more strongly associated with RAS episodes than physical stressors. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5401988 Sat, 12 Nov 2011 05:00:00 +0100 5401988 Oral fluid and hepatitis A, B and C: A literature review http://www.medworm.com/index.php?rid=5527627&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01123.x Conclusion:  There is some evidence that hepatitis viruses A, B and C are present in oral fluids, particularly whole saliva and gingival crevicular fluid and may thus be possible sources of viral detection in clinical diagnosis and monitoring. However, the data are inconsistent and warrant the need for well‐planned longitudinal studies to explore the precise frequency of oral carriage of such viruses and to determine the virological and host factors that may influence the oral presence of hepatitis A, B and C viruses. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5527627 Tue, 01 Nov 2011 04:00:00 +0100 5527627 Short telomeres in an oral precancerous lesion: Q‐FISH analysis of leukoplakia http://www.medworm.com/index.php?rid=5460319&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01120.x Conclusion:  Ortho‐keratotic dysplasia appears to be frequently associated with carcinoma, chromosomal instability, and excessively shortened telomeres, not only in the lesion itself but also in the surrounding background. Therefore, when this type of leukoplakia is recognized in the oral region, strict follow‐up for oral squamous cell carcinoma is necessary, focusing not only on the areas of leukoplakia, but also the surrounding background. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5460319 Tue, 01 Nov 2011 04:00:00 +0100 5460319 Risk of oral cavity malignancies in patients with cutaneous melanoma http://www.medworm.com/index.php?rid=5450870&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01118.x (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5450870 Tue, 01 Nov 2011 04:00:00 +0100 5450870 Coexpression of hypoxia‐inducible factor‐2α, TWIST2, and SIP1 may correlate with invasion and metastasis of salivary adenoid cystic carcinoma http://www.medworm.com/index.php?rid=5433463&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01114.x Conclusion:  It is proposed that the elevated expression of HIF‐2α, TWIST2, and SIP1 can contribute to invasion and metastasis of ACC, and there might be some correlation between the hypoxia microenvironment and EMT in ACC. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5433463 Tue, 01 Nov 2011 04:00:00 +0100 5433463 Impacts of HIV infection and long‐term use of antiretroviral therapy on the prevalence of oral human papilloma virus type 16 http://www.medworm.com/index.php?rid=5424231&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01117.x Conclusion:  We conclude that the prevalence of oral HPV‐16 infection and the copy numbers of the virus are increased by HIV infection. Neither the use of ART nor its duration significantly affected the virus. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5424231 Tue, 01 Nov 2011 04:00:00 +0100 5424231 Multiple myeloma vs. breast cancer patients with bisphosphonates‐related osteonecrosis of the jaws: a comparative analysis of response to treatment and predictors of outcome http://www.medworm.com/index.php?rid=5411485&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01095.x Conclusions:  Both groups of cancer patients experienced clinical and symptomatological remission regardless their malignancy, but BC patients earlier than MM patients. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5411485 Tue, 01 Nov 2011 04:00:00 +0100 5411485 Excisional biopsy for management of lateral tongue leukoplakia http://www.medworm.com/index.php?rid=5401987&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01106.x Conclusion:  Leukoplakia of the lateral tongue is highly coexistent with malignancy, and incisional biopsy frequently leads to underdiagnosis. Therefore, complete excision with adequate margin is warranted for leukoplakia of the lateral tongue, preferably under general anesthesia, which could be performed with minimal morbidity and function preservation. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5401987 Tue, 01 Nov 2011 04:00:00 +0100 5401987 Local effects of intra‐articular injection of anti‐rabbit tumor necrosis factor alpha monoclonal antibody in antigen‐induced arthritis of the rabbit temporomandibular joint http://www.medworm.com/index.php?rid=5325869&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01056.x Conclusions:  Intra‐articular injection of anti‐rabbit TNFα mAb in mono‐arthritis model was effective to control local inflammation and degenerative joint changes. Further, low‐dose IA injection of antibody may not have systemic side effects. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5325869 Wed, 19 Oct 2011 03:20:41 +0100 5325869 Effects of long‐term use of antiretroviral therapy on the prevalence of oral Epstein–Barr virus http://www.medworm.com/index.php?rid=5298472&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01089.x Conclusions:  Prevalence of oral EBV was significantly higher in HIV‐infected subjects than non‐HIV‐controls. The numbers of the virus were significantly decreased by ART. Long‐term use of ART did not increase oral EBV. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5298472 Sat, 01 Oct 2011 04:00:00 +0100 5298472 Reply to H. M. Ögmundsdóttir & W. P. Holbrook by M. Ebrahimi et al. http://www.medworm.com/index.php?rid=5276558&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01059.x (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5276558 Sat, 01 Oct 2011 04:00:00 +0100 5276558 Bisphosphonates‐related osteonecrosis of the jaws: a concise review of the literature and a report of a single‐centre experience with 151 patients http://www.medworm.com/index.php?rid=5276555&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01091.x J Oral Pathol Med (2011)The osteonecrosis of the jaws (ONJ) is an adverse side effect of long‐term bisphosphonate therapy (BPT) firstly described in 2003. The aetiology of BRONJ remains unknown, and the pathogenesis seems multifactorial and related to several local or general factors. Many expert panel developed preventive protocols to facilitate specialists involved in the multidisciplinary management of BRONJ patients. In this paper, we present a concise review of the literature, and we report the experience of the University of Parma with 151 patients that assumed BPT for both oncological (121 patients) and non‐oncological (30 patients) diseases. One hundred and thirty‐nine BRONJ sites were treated with different approaches (surgical and non‐surgical, laser‐assisted and non‐... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5276555 Sat, 01 Oct 2011 04:00:00 +0100 5276555 Effect of pollen from Typha angustata on hydrogen peroxide induced toxicity in osteoblastic MC3T3‐E1 cells http://www.medworm.com/index.php?rid=5276557&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01077.x Conclusion:  These results suggest that the pollen of T. angustata may be useful for the protection of H2O2‐induced oxidative damage and dysfunction in osteoblasts. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5276557 Fri, 30 Sep 2011 04:00:00 +0100 5276557 Role of anti‐β1 adrenergic antibodies from patients with periodontitis in cardiac dysfunction http://www.medworm.com/index.php?rid=5276556&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01090.x Conclusion:  This manuscript describes that patients with periodontitis showed increased levels of serum IgG with reactive activity against β1‐AR. Those patients demonstrated decrease in heart rate, and IgG derived from their sera induced aberrant contractility of heart atrium. We propose that periodontitis increases the risk of cardiovascular diseases, although it increases anti‐β1‐AR autoantibody that alters myocardial contractility. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5276556 Fri, 30 Sep 2011 04:00:00 +0100 5276556 High mTOR expression is associated with a worse oncological outcome in laryngeal carcinoma treated with postoperative radiotherapy: a pilot study http://www.medworm.com/index.php?rid=5240958&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01083.x Conclusions:  mTOR should be studied as a potential predictor for identifying LSCCs at higher risk of early recurrence after postoperative RT. New therapeutic strategies should be investigated in LSCC, including the use of rapalogs associated with conventional chemotherapeutic regimens in combination with RT. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5240958 Thu, 22 Sep 2011 04:00:00 +0100 5240958 Altered expression of miR‐21, miR‐125b, and miR‐203 indicates a role for these microRNAs in oral lichen planus http://www.medworm.com/index.php?rid=5240957&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01084.x Conclusion:  Results indicate a role for the studied microRNAs in changes seen in OLP. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5240957 Thu, 22 Sep 2011 04:00:00 +0100 5240957 Antigen‐presenting cell marker expression and phagocytotic activity in periodontal ligament cells http://www.medworm.com/index.php?rid=5240956&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01086.x Conclusions:  These results suggest that PDL cells do not only represent bystanders in periodontal infections, but display non‐professional APC characteristics, suggesting possible participation in immune reactions of the oral cavity. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5240956 Thu, 22 Sep 2011 04:00:00 +0100 5240956 Pharmacokinetics study about topical clobetasol on oral mucosa http://www.medworm.com/index.php?rid=5240955&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01087.x Conclusions:  Our study validates clobetasol systemic transmucosal absorption, also recommending a careful monitoring of patients in corticosteroid therapy to avoid local and systemic adverse effects. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5240955 Thu, 22 Sep 2011 04:00:00 +0100 5240955 Expression of odontogenic ameloblast‐associated protein, amelotin, ameloblastin, and amelogenin in odontogenic tumors: immunohistochemical analysis and pathogenetic considerations http://www.medworm.com/index.php?rid=5240961&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01079.x In this study, we have examined the presence and distribution of odontogenic ameloblast‐associated protein (ODAM), amelotin (AMTN), ameloblastin (AMBN), and amelogenin (AMEL) by immunohistochemistry in samples of adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), developing odontoma, ameloblastoma, calcifying cystic odontogenic tumor (CCOT), ameloblastic fibroma (AF), myxoma, odontogenic fibroma (OF), and reduced enamel epithelia (REE). Positive results were obtained in those tumors with epithelial component, except for AF, OF, and ameloblastoma. ODAM was found around mineralized structures (dystrophic calcifications) and CEOT’s amyloid, whereas AMTN stained the eosinophilic material of AOTs. The CCOT transitory cells to ghost cells were strongly posit... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5240961 Wed, 21 Sep 2011 04:00:00 +0100 5240961 Endothelial cell Bcl‐2 and lymph node metastasis in patients with oral squamous cell carcinoma http://www.medworm.com/index.php?rid=5240960&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01081.x Conclusions:  Collectively, this work unveiled a mechanism for the induction of Bcl‐2 in lymphatic endothelial cells and suggested that endothelial cell Bcl‐2 contributes to lymph node metastasis in patients with oral squamous cell carcinoma. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5240960 Wed, 21 Sep 2011 04:00:00 +0100 5240960 Warty dyskeratoma/focal acantholytic dyskeratosis – an update on a rare oral lesion http://www.medworm.com/index.php?rid=5240959&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01082.x Conclusion:  Warty dyskeratoma/FAD are uncommon oral lesions which are not encountered in the daily practice of oral pathologists. The absence of an association of oral lesions with the pilosebaceous apparatus suggests that they are probably distinctly different from cutaneous ones. As such, we suggest the histologic term isolated FAD for oral lesions, rather than WD. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5240959 Wed, 21 Sep 2011 04:00:00 +0100 5240959 A non‐invasive oral rinse assay predicts bone marrow engraftment and 6 months prognosis following allogeneic hematopoietic stem cell transplantation http://www.medworm.com/index.php?rid=5240962&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01076.x Conclusion:  We conclude that monitoring the timing of neutrophil delivery to the oral tissues with a non‐invasive oral rinse has the potential to allow the physician to identify those patients who are at a high risk of HSCT failure within just a few weeks of the initiation of treatment. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5240962 Tue, 20 Sep 2011 04:00:00 +0100 5240962 Immunoexpression of TNF‐α and TGF‐β in central and peripheral giant cell lesions of the jaws http://www.medworm.com/index.php?rid=5228646&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01075.x Conclusions:  Our results suggest that, in CGCL, coordinated interactions between TGF‐β and TNF‐α may be important for osteoclastogenesis and bone resorption. PGCL occasionally cause bone resorption but to a lower extent, a fact that might be explained by the lower expression of TGF‐β in these lesions. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5228646 Tue, 13 Sep 2011 04:00:00 +0100 5228646 Oral squamous cell carcinoma grading systems – analysis of the best survival predictor http://www.medworm.com/index.php?rid=5212508&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01068.x Conclusion:  Of the grading systems evaluated, Histologic Risk Assessment demonstrated the best results for survival prediction in oral squamous cell carcinoma. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5212508 Thu, 08 Sep 2011 04:00:00 +0100 5212508 Field effect in oral precancer as assessed by DNA flow cytometry and array‐CGH http://www.medworm.com/index.php?rid=5252460&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01085.x Conclusion:  DNA aneuploidy and Ch‐Abs in MFs, the last ones being mainly gains, indicate an early onset of field effect in oral carcinogenesis. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5252460 Thu, 01 Sep 2011 04:00:00 +0100 5252460 Evaluation of the clinical efficacy of a betaine‐containing mouthwash and an intraoral device for the treatment of dry mouth http://www.medworm.com/index.php?rid=5240954&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01088.x Conclusions:  The daily use of a night guard and BET‐containing mouthwash was seen to improve dry mouth during the 4‐week duration of the study. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5240954 Thu, 01 Sep 2011 04:00:00 +0100 5240954 A clinicopathological study on verrucous hyperplasia and verrucous carcinoma of the oral mucosa http://www.medworm.com/index.php?rid=5228645&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01078.x Conclusion:  Clinicopathological features of VH and VC in China were elucidated. Elderly patient with oral verrucous lesion located on the lower lip correlates with higher risk of carcinoma. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5228645 Thu, 01 Sep 2011 04:00:00 +0100 5228645 Oral motor performance in spastic cerebral palsy individuals: are hydration and nutritional status associated? http://www.medworm.com/index.php?rid=5212507&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01074.x Conclusion:  Cerebral palsy individuals appear to present impaired adequate hydration due to compromised oral motor performance. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5212507 Thu, 01 Sep 2011 04:00:00 +0100 5212507 Recurrent aphthous ulcers—a Toll‐like receptor–mediated disease? http://www.medworm.com/index.php?rid=5198446&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01064.x Conclusions:  Normal TLR architecture prevents inflammatory responses against normal microbes but still contains a deep TLR+, PAMP‐reactive dormant defense zone. In RAU, the TLR+, PAMP‐reactive zone extends to surface or subsurface exposed to microbial PAMPs. TLR reactivity is further enhanced by recruitment of inflammatory leukocytes forming a new deep line of defense. The organization of the TLR system in healthy mucosa and its changes in RAU are compatible with active pathogenic involvement of TLRs, which together with the typical clinical picture and course suggest that RAU is a TLR‐mediated disease. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5198446 Wed, 31 Aug 2011 23:00:00 +0100 5198446 Fine‐needle aspiration cytology: a reliable tool in the diagnosis of salivary gland lesions http://www.medworm.com/index.php?rid=5171625&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01069.x Conclusion:  Fine‐needle aspiration cytology is found to be a good sensitive and specific technique for the diagnosis of most of the salivary gland lesions. FNAC should be adopted as an initial investigation for all salivary gland swellings in conjunction with other investigations where appropriate. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5171625 Sun, 28 Aug 2011 23:00:00 +0100 5171625 Evaluation of oral mucosal diseases: inter‐ and intra‐observer analyses http://www.medworm.com/index.php?rid=5171624&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01070.x Conclusions:  Follow‐up evaluations of oral mucosal lesions are performed better by oral medicine practitioners compared to other dental specialists. The incorporation of a calibration label in the clinical images seems to enhance evaluation. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5171624 Sun, 28 Aug 2011 23:00:00 +0100 5171624 Evaluation of immunohistochemical expression of p53, p21, p27, cyclin D1, and Ki67 in oral and oropharyngeal squamous cell carcinoma http://www.medworm.com/index.php?rid=5171623&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01071.x Conclusions:  Our results suggest that the biomarkers p53, p21, p27, cyclin D1, and Ki67 have no impact on treatment response and survival in patients with oral and oropharyngeal cancer treated with preoperative chemoradiation. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5171623 Sun, 28 Aug 2011 23:00:00 +0100 5171623 The prevalence of dysplasia and malignant lip lesions in transplant patients http://www.medworm.com/index.php?rid=5171622&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01072.x Conclusion:  All transplant patients should be regularly screened for lip malignancies and consulted on smoking and sunlight exposure. HLA‐B mismatch does appear to make these patients more susceptible to dysplastic/malignant changes. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5171622 Sun, 28 Aug 2011 23:00:00 +0100 5171622 Head and neck amyloidosis: clinicopathological features and immunohistochemical analysis of 14 cases http://www.medworm.com/index.php?rid=5171621&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01073.x Conclusions:  Our results show that the head and neck region is preferentially affected by systemic AL‐amyloidosis, usually associated with plasma cell dyscrasia. Interestingly, two cases affected by inflammatory rheumatic diseases presented AL‐amyloid deposition. Moreover, even after pretreatment with potassium permanganate, which was helpful in highlighting the presence of AL‐amyloid, in agreement with the IHC findings, clinical classifications should be carefully made in systemic amyloidosis. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5171621 Sun, 31 Jul 2011 23:00:00 +0100 5171621 Role of cytochrome P‐450 genetic polymorphisms in oral carcinogenesis http://www.medworm.com/index.php?rid=5072436&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01067.x J Oral Pathol Med (2011)Oral cancer is one of the most frequent head and neck cancers, and epidemiological studies have shown that smoking is a major risk factor in this pathology. However, as not all smokers develop oral cancer, some individuals must be more susceptible to develop this disease. This individual susceptibility has been related to different genetic variants in metabolizing enzymes. The cytochrome P‐450 (CYP) family of enzymes metabolizes tobacco‐related carcinogens producing reactive metabolites, which could cause DNA damage. Because of their functional role in the metabolism of tobacco‐related compounds, the genetic polymorphisms found in the genes that code for CYP enzymes have been suggested to modulate oral cancer risk and contribute to individual susceptibility. I... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5072436 Fri, 29 Jul 2011 16:44:15 +0100 5072436 Long‐term sequential receptor activator of NF‐κB ligand (RANKL) and osteoprotegrin (OPG) expression in lipopolysaccharide‐induced rat periapical lesions http://www.medworm.com/index.php?rid=5072438&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01065.x Conclusion:  This study may be the first to demonstrate the long‐term RANKL and OPG expression every week from week 1 to week 8 using LPS to produce periapical infection in a Wistar rat model. The long‐term findings of high expressions of RANKL and OPG further extend the potential application of the Wistar rat model for future experimental trials using RANKL inhibitor to evaluate the treatment outcome for LPS‐induced rat periapical lesions. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5072438 Wed, 27 Jul 2011 23:00:00 +0100 5072438 The expression and significance of MRP1, LRP, TOPOIIβ, and BCL2 in tongue squamous cell carcinoma http://www.medworm.com/index.php?rid=5072437&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01066.x Conclusion:  Our results suggest that the high expressions of MRP1, LRP, and BCL2 and low expression of TOPOIIβ in patients with tongue carcinoma indicates that intrinsic drug resistance may exist in tongue carcinoma, and is associated with tumor differentiation and cisplatin resistance in tongue carcinoma. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5072437 Wed, 27 Jul 2011 23:00:00 +0100 5072437 Changes in miRNA expression in sera and correlation to duration of disease in patients with multifocal mucosal lichen planus http://www.medworm.com/index.php?rid=5043039&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01063.x Discussion:  Even if no specific LP‐associated miRNA profile was found, data clearly indicate that miRNAs could play a role in the earlier phases of lichen planus. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5043039 Thu, 21 Jul 2011 17:29:53 +0100 5043039 Factors predicting malignant transformation in oral potentially malignant disorders among patients accrued over a 10‐year period in South East England http://www.medworm.com/index.php?rid=5043041&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01054.x Conclusions:  In 2.6% of cases, OPMDs transformed to invasive cancer for a total person follow‐up time of 12 273 years (mean 9.04 years). The severity of dysplasia is a significant predictor for malignant transformation. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5043041 Sun, 17 Jul 2011 23:00:00 +0100 5043041 Low prevalence of human papillomavirus infection in the healthy oral mucosa of a Northern Italian population http://www.medworm.com/index.php?rid=5043040&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01062.x In this study, the prevalence of oral HPV infection was evaluated in 81 randomly selected Northern Italian subjects with clinically normal oral mucosa using a nested PCR on DNA extracted by oral smears.Results and conclusions:  No HPV‐related lesions were detectable in any of the smears analyzed by cytological approach. nPCR identified HPV DNA in only one (1.2%) of the specimens obtained from clinically healthy oral mucosa and subsequent characterization assigned the positive case to HPV type 90.These data suggest that the incidence of HPV infection in the healthy population might be very low and that other risk factors are likely responsible to promote oral carcinogenesis. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5043040 Sun, 17 Jul 2011 23:00:00 +0100 5043040 Letter to the Editor http://www.medworm.com/index.php?rid=4994933&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01059.x (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4994933 Fri, 01 Jul 2011 23:00:00 +0100 4994933 Interleukin‐2, interleukin‐6 and T regulatory cells in peripheral blood of patients with Behçet’s disease and recurrent aphthous ulcerations http://www.medworm.com/index.php?rid=5012669&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01061.x Conclusions:  These results indicate that CD4+ CD25bright T regulatory cells may be contributing factor in the pathogenesis of BD and RAU. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=5012669 Thu, 30 Jun 2011 23:00:00 +0100 5012669 Corrigendum http://www.medworm.com/index.php?rid=4994934&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01030.x (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4994934 Thu, 30 Jun 2011 23:00:00 +0100 4994934 Comment on the paper by Ebrahimi et al published in Journal of Oral Pathology & Medicine, 2011; 40: 281–285 http://www.medworm.com/index.php?rid=4994932&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01060.x (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4994932 Thu, 30 Jun 2011 23:00:00 +0100 4994932 TGF‐β1 regulates the invasive and metastatic potential of mucoepidermoid carcinoma cells http://www.medworm.com/index.php?rid=4956246&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01051.x Conclusion:  These results unveil a critical role for TGF‐β1 in the progression of mucoepidermoid carcinomas and suggest that patients with this malignancy may benefit from therapeutic inhibition of the effectors of the TGF‐β1 pathway. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4956246 Mon, 20 Jun 2011 23:00:00 +0100 4956246 Increased fibroblast density in actinic cheilitis: association with tryptase‐positive mast cells, actinic elastosis and epithelial p53 and COX‐2 expression http://www.medworm.com/index.php?rid=4956245&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01057.x Conclusions:  Fibroblasts are increased in AC, and they are associated with mast cell density, epithelial p53 and COX‐2 expression, and actinic elastosis. Therefore, fibroblasts may contribute to lip photodamage and could be considered useful markers of early lip carcinogenesis. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4956245 Mon, 20 Jun 2011 23:00:00 +0100 4956245 Role of human papillomavirus infection in carcinogenesis of oral squamous cell carcinoma with evidences of prognostic association http://www.medworm.com/index.php?rid=4844427&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01046.x Conclusions:  Human papillomavirus infections may play a unique role in oral carcinogenesis. Our data strongly suggest that human papillomavirus‐positive oral squamous cell carcinomas comprise a distinct clinical and pathological disease entity that appears related to a better outcome with longer survival and bears a causally associated relationship different from other carcinogenic mechanisms. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4844427 Thu, 19 May 2011 23:00:00 +0100 4844427 Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst – a clinicopathologic analysis of 116 reported cases http://www.medworm.com/index.php?rid=4956244&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01058.x Conclusion:  PIOSCC has a predilection for men (M/F ratio of 2.22:1), affects mainly adults in their 6–8th decades, occurs most frequently (79%) in the mandible, and is associated mainly with a residual/radicular cyst. Histologically, the well‐to‐moderately differentiated SCC was the most common. Surgery alone or combined therapy of surgery and radiation was the most common approach. The prognosis is 62% surviving 2 years and 38% 5 years. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4956244 Sat, 30 Apr 2011 23:00:00 +0100 4956244 DNA hypermethylation as an epigenetic mark for oral cancer diagnosis http://www.medworm.com/index.php?rid=4906631&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01055.x J Oral Pathol Med (2011)Oral cancer is the largest group of cancers which fall into the head and neck category. While genetic alterations in oral cancer have long been documented, the effect of epigenetic changes is more recent. The recent explosion in science of how chromatin organization modulates the gene expression has highlighted the epigenetic mechanism of oral cancer pathogenesis. DNA methylation, which is an important epigenetic marker, is perhaps the best characterized chemical modification of mammalian DNA and provides a stable, heritable, and critical component of epigenetic regulation. This review attempts to decipher the epigenetic aspects of oral cancer by evaluating the DNA methylation status through its various stages from normal to potentially malignant to malignant states... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4906631 Sat, 30 Apr 2011 23:00:00 +0100 4906631 Immunohistochemical assessment of CD1a‐positive Langerhans cells and their relationship with E‐cadherin in minor salivary gland tumors http://www.medworm.com/index.php?rid=4879634&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01052.x Conclusions:  The lack of CD1a‐positive in malignant salivary gland tumors facilitates the neoplastic development and suggests that these cells might be useful as auxiliary diagnostic and prognostic tool in minor salivary gland tumors. Furthermore, it is suggested that E‐cadherin mediates cell adhesion in these tumors although we did not demonstrate significance. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4879634 Sat, 30 Apr 2011 23:00:00 +0100 4879634 ORAOV1 is amplified in oral squamous cell carcinoma http://www.medworm.com/index.php?rid=4874294&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01053.x Conclusion:  The overexpression of ORAOV1 in non‐tumoral margin samples can occur in the absence of amplification. The weak correlation between ORAOV1 amplification and expression in OSSC suggests that ORAOV1 expression can be regulated by mechanisms other than gene amplification. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4874294 Sat, 30 Apr 2011 23:00:00 +0100 4874294 Utility of chemiluminescence (ViziLite™) in the detection of oral potentially malignant disorders and benign keratoses http://www.medworm.com/index.php?rid=4866927&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01048.x Conclusion:  While ViziLite has the ability to detect OPMD, it does not accurately delineate dysplastic lesions. The device can be used as a general oral mucosal examination system and may in particular improve the visualization of leukoplakias. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4866927 Sat, 30 Apr 2011 23:00:00 +0100 4866927 The role of α9β1 integrin in modulating epithelial cell behaviour http://www.medworm.com/index.php?rid=4856929&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01050.x Conclusions:  The α9β1 integrin may play a key role in modulation of tumour behaviour including enhanced cell migration and expression of matrix‐degrading proteases. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4856929 Sat, 30 Apr 2011 23:00:00 +0100 4856929 Midkine expression in oral squamous cell carcinoma and leukoplakia http://www.medworm.com/index.php?rid=4844426&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01049.x Conclusion:  OCSCC, particularly late‐stage tumors, exhibits increased MK expression, which may be involved in tumor progression via upregulation of anti‐apoptotic genes, as shown by the augmented bcl‐2 positivity in MK‐positive tumors. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4844426 Sat, 30 Apr 2011 23:00:00 +0100 4844426 Differential expression of toll‐like receptor mRNAs in recurrent aphthous ulceration http://www.medworm.com/index.php?rid=4795853&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01047.x Conclusion:  Our results support the hypothesis that a subset of RAU patients has fewer TLR expression that have been tentatively implicated in anti‐inflammatory effects. This derangement of TLR gene expression may cause an overlay exuberant inflammation reaction in situations where normal individuals are resistant. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4795853 Sat, 30 Apr 2011 23:00:00 +0100 4795853 A study of the clinical activity of a gel combining monocaprin and doxycycline: a novel treatment for herpes labialis http://www.medworm.com/index.php?rid=4769088&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01037.x Conclusion:  Combining monocaprin with low‐dose doxycycline offers an effective treatment for herpes labialiss, significantly reducing time to healing and pain compared with the placebo and monocaprin alone. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4769088 Sat, 30 Apr 2011 23:00:00 +0100 4769088 Cell apoptosis and proliferation in salivary glands of Sjögren’s syndrome http://www.medworm.com/index.php?rid=4750036&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01042.x Conclusion:  The results of this work are indicative of a high degree of proliferation (85%) in infiltrated lymphocytes (IL) associated with SS which, according the literature, could be considered a risk. Furthermore, the markers used in this work are widely known and represent a lower cost than others and can be used to determine risk groups within the population of SS patients, enabling their follow‐up. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4750036 Tue, 26 Apr 2011 18:26:02 +0100 4750036 Human dental pulp stem cells derived from different cryopreservation methods of human dental pulp tissues of diseased teeth http://www.medworm.com/index.php?rid=4743127&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01040.x Conclusion:  Our results indicate that hDPSCs isolated from diseased but vital teeth of various tooth types can be stored in liq N2 for future usage. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4743127 Sat, 23 Apr 2011 20:16:25 +0100 4743127 Identification of Herpesvirus types 1‐8 in oral cavity of children/adolescents with chronic renal failure http://www.medworm.com/index.php?rid=4727996&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01028.x J Oral Pathol Med (2011)The aim of this investigation was to identify the prevalence of herpesvirus types 1–8 in the oral cavity of subjects with chronic renal failure (CRF) and healthy subjects and compare the two groups, and also correlate the presence of the virus with some characteristics of CRF disease (the type of treatment, drugs administered for CRF and the presence of oral manifestations). The sample was made up of 60 subjects (aged 4–20) divided into the renal group (RG) and healthy group. Anamnesis, intraoral examination and collection of clinical specimens (swab smears) were carried out. The nested‐PCR technique was used to identify the viral species. The results showed a higher prevalence of HSV‐1 (20%), human herpes virus (HHV)‐6B (83%), CMV (13.3%) in RG group than... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4727996 Wed, 20 Apr 2011 05:46:32 +0100 4727996 Expression form of p53 and PCNA at the invasive front in oral squamous cell carcinoma: correlation with clinicopathological features and prognosis http://www.medworm.com/index.php?rid=4727999&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01032.x Conclusion:  We suggest that it is important to investigate the expression of p53 and PCNA at the invasive front of OSCC. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4727999 Sun, 17 Apr 2011 23:00:00 +0100 4727999 Grading oral epithelial dysplasia: analysis of individual features http://www.medworm.com/index.php?rid=4727998&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01033.x Conclusions:  These variations may account in part for the lack of reproducibility and poor predictive value of the grading systems in current use and could inform the design of future grading systems. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4727998 Sun, 17 Apr 2011 23:00:00 +0100 4727998 Comparison of antioxidant enzymes activity and the concentration of uric acid in the saliva of patients with oral cavity cancer, odontogenic cysts and healthy subjects http://www.medworm.com/index.php?rid=4727997&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01045.x J Oral Pathol Med (2011)Chronic inflammation is related to oxidative stress and is still believed to be the cause of carcinogenesis. Patients with oral cavity cancer (OCC) exhibited lower total antioxidant capacity, uric acid (UA) concentration, salivary peroxidise (SPO) and superoxide dismutase (SOD) activity in their saliva than did healthy subjects. This could be a risk factor for tumour induction. Odontogenic cysts also arise in response to locally acting proinflammatory factors, for example, a gangrenous tooth. Furthermore, cyst development is accompanied by chronic inflammation. There are some reports in the literature concerning primary tumours such as squamous cell carcinomas arising from odontogenic cysts. The reason for this transformation is still unknown. The aim of this study ... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4727997 Sun, 17 Apr 2011 23:00:00 +0100 4727997 Tumor budding correlates with poor prognosis and epithelial‐mesenchymal transition in tongue squamous cell carcinoma http://www.medworm.com/index.php?rid=4700096&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01041.x Conclusions:  Tumor budding, which associates with epithelial–mesenchymal transition, is a frequent event and appears to be an independent prognostic factor in TSCC. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4700096 Tue, 12 Apr 2011 21:40:36 +0100 4700096 Combining factors on protein and gene level to predict radioresponse in head and neck cancer cell lines http://www.medworm.com/index.php?rid=4700101&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01036.x Conclusion:  These data indicate that the IR of 42 HNSCC cell lines can be predicted by a panel of factors on both the protein and gene levels. Moreover, among the investigated factors, survivin was the most promising biomarker of radioresponse. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4700101 Sun, 10 Apr 2011 23:00:00 +0100 4700101 Effects of gustatory stimulants of salivary secretion on salivary pH and flow in patients with Sjögren’s syndrome: a randomized controlled trial http://www.medworm.com/index.php?rid=4700100&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01038.x Conclusions:  In Xerostomic Primary Sjögren syndrome patients, gustatory stimulants of salivary secretion based on acid mail only with fluoride and xylitol present similar salivary stimulation capacity when compared to citric acid‐based ones, besides significantly reducing the number of salivary pH drops below 4.5. This could be related to a diminished risk for dental erosion and should be confirmed with further studies. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4700100 Sun, 10 Apr 2011 23:00:00 +0100 4700100 Association between recurrent aphthous stomatitis and inheritance of a single‐nucleotide polymorphism of the NOS2 gene encoding inducible nitric oxide synthase http://www.medworm.com/index.php?rid=4700099&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01039.x Conclusion:  Inheritence of a NOS2 single‐nucleotide polymorphism rs2297518 is associated with increased risk of recurrent aphthous stomatitis in a Jordanian population. Confirmatory studies in other populations and investigation of other NOS2 gene polymorphisms will enhance our understanding of the functional basis of this association and help elucidate the role of inducible nitric oxide synthase in recurrent aphthous stomatitis. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4700099 Sun, 10 Apr 2011 23:00:00 +0100 4700099 Areca nut extracts enhance the development of CD11b+Gr‐1+ cells with the characteristics of myeloid‐derived suppressor cells in antigen‐stimulated mice http://www.medworm.com/index.php?rid=4700098&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01043.x Conclusions:  Our results suggested that areca nut constituents, in particular, polyphenols enhanced the development of myeloid‐derived suppressor cells in vivo, which may be a critical mechanism linking inflammation and the compromised immunity reported to be associated with the pathophysiology of areca‐related oral diseases. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4700098 Sun, 10 Apr 2011 23:00:00 +0100 4700098 Migration‐stimulating factor as a novel biomarker in salivary gland tumours http://www.medworm.com/index.php?rid=4700097&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01044.x Conclusions:  These immunohistochemical and functional studies suggest that MSF expression is a potentially useful biomarker of salivary gland tumour progression. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4700097 Sun, 10 Apr 2011 23:00:00 +0100 4700097 Histone deacetylase‐1 and ‐2 expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival http://www.medworm.com/index.php?rid=4672836&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01031.x Conclusions:  The present study supported evidence that HDACs may participate in the formation and progression of mobile tongue SCC, reinforcing their possible use as biomarkers as also the therapeutic utility of HDAC inhibitors in mobile tongue SCC chemoprevention and treatment. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4672836 Fri, 01 Apr 2011 23:00:00 +0100 4672836 Oral mucosa in children with Prader–Willi syndrome http://www.medworm.com/index.php?rid=4672835&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01034.x Conclusions:  Abnormal saliva secretion and self‐destructive behaviours in children with Prader–Willi syndrome predispose them to injurious lesions in the oral mucosa, and possibly, to oral candidiosis. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4672835 Fri, 01 Apr 2011 23:00:00 +0100 4672835 Biologics, an alternative therapeutic approach for oral lichen planus http://www.medworm.com/index.php?rid=4678754&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01029.x J Oral Pathol Med (2011)Oral lichen planus (OLP) is generally accepted as a chronic and T‐cell‐mediated autoimmune disease, whose immunopathogenesis may involve antigen presentation, T‐cell activation and migration as well as, possibly, tumor necrosis factor‐alpha (TNF‐α)‐induced keratinocytes apoptosis. However, present treatment options for OLP are far from being satisfactory. Recent advances in understanding the pathogenesis of OLP, progress in biologics, and the success of biologic therapies in OLP indicate that biologic agents are facing expanding indications in OLP. In this review, we mainly discuss the role of T cells in the pathogenesis of OLP and several biologic therapies that directly and/or indirectly target T cells to treat OLP. (Source: Journal of Oral Pathology ... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4678754 Thu, 31 Mar 2011 23:00:00 +0100 4678754 The high expression level of programmed death‐1 ligand 2 in oral lichen planus and the possible costimulatory effect on human T cells http://www.medworm.com/index.php?rid=4672834&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01035.x Conclusion:  These data show that the increased expression of PD‐L2, as a costimulatory molecule, may have an important modulatory function on the local immune responses of OLP in vivo. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4672834 Thu, 31 Mar 2011 23:00:00 +0100 4672834 Aberrant expression of p53, p16INK4a and Ki‐67 as basic biomarker for malignant progression of oral leukoplakias http://www.medworm.com/index.php?rid=4633407&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01026.x Conclusions:  We propose the combined p53/p16INK4a/Ki‐67 alteration as a basic marker to define high risk leukoplakia patients. Lesions not showing this alteration appear to be harmless. Future studies should validate these findings and search for proteins which can further improve the PPV of the proposed basic marker. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4633407 Fri, 25 Mar 2011 22:59:38 +0100 4633407 The use of tobacco‐free betel‐quid in conjunction with alcohol/tobacco impacts early‐onset age and carcinoma distribution for upper aerodigestive tract cancer http://www.medworm.com/index.php?rid=4556391&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01022.x Conclusions:  Tobacco‐free betel‐quid, in conjunction with alcohol and/or tobacco consumption, impacts early cancer occurrence for specific UADT‐SCC and influences tumor site incidence pattern of these neoplasms. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4556391 Tue, 08 Mar 2011 00:00:00 +0100 4556391 Salivary osmolality and hydration status in children with cerebral palsy http://www.medworm.com/index.php?rid=4537653&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01027.x Conclusion:  Cerebral palsy children seem to present impaired adequate hydration status. Since the possible hypohydration condition may be reflected in saliva fluid, which could compromise the protective function exerted by saliva, the earlier this condition is identified the greater the chances of administering preventive measures. Moreover, salivary osmolality is a reliable parameter that reflects changes in plasma and urine. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4537653 Wed, 02 Mar 2011 00:00:00 +0100 4537653 Rituximab for the treatment of corticosteroid – refractory pemphigus vulgaris with oral and skin manifestations http://www.medworm.com/index.php?rid=4562824&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01017.x We report here six cases of patients presenting with oral and skin PV with recalcitrant or rapidly progressive disease treated with a novel dosing regimen of rituximab as a single agent. All patients achieved a complete response to a maximum follow‐up of 34 months. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4562824 Tue, 01 Mar 2011 00:00:00 +0100 4562824 Immunohistochemical study of the expression of fatty acid synthase and Ki‐67 in salivary gland tumors http://www.medworm.com/index.php?rid=4556390&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01023.x Conclusion:  It is suggested that the fat metabolism in salivary gland tumors is related to maintenance of cell differentiation. Its expression prevailed in benign tumors, while Ki‐67 prevailed in the mucoepidermoid carcinoma, demonstrating its high proliferation rate, followed by the cystic adenoid carcinoma and polymorphous low grade adenocarcinoma. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4556390 Tue, 01 Mar 2011 00:00:00 +0100 4556390 Expression of metallothionein in ameloblastoma. A regulatory molecule? http://www.medworm.com/index.php?rid=4546497&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01025.x Conclusions:  This protein may have an impact on ameloblastoma behavior. Metallothionein would act as a zinc reservoir for important proteases related to ameloblastoma biology, such as MMPs. This protein could also display pro‐mitotic and anti‐apoptotic features in the tumor. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4546497 Tue, 01 Mar 2011 00:00:00 +0100 4546497 The effect of proteoglycans inhibited on the neurotropic growth of salivary adenoid cystic carcinoma http://www.medworm.com/index.php?rid=4537652&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01024.x Conclusion:  Xylosyltransferase‐I gene of SACC cells was silenced by RNA interference technology, proteoglycans secretion was reduced and neurotropic invasion behavior of SACC was inhibited obviously. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4537652 Tue, 01 Mar 2011 00:00:00 +0100 4537652 Validity and reliability of a newly developed quality of life questionnaire for patients with chronic oral mucosal diseases http://www.medworm.com/index.php?rid=4519168&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01021.x Conclusions:  In conclusion, this study has demonstrated that the COMDQ is a valid and reliable measure to assess quality of life in patients with chronic oral mucosal diseases and therefore will be a valuable instrument in the management of these conditions. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4519168 Fri, 25 Feb 2011 20:04:05 +0100 4519168 Induction of Sca‐1 in the duct cells of the mouse submandibular gland by obstruction of the main excretory duct http://www.medworm.com/index.php?rid=4519171&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01011.x J Oral Pathol Med (2011)The effect of ligation of the main excretory duct (MED) of the mouse submandibular gland (SMG) on the expression of Sca‐1, a stem cell antigen, was examined by Western blotting and immunohistochemistry. By Western blotting, the expression of Sca‐1 with a molecular weight of 18 kDa was identified in the normal gland. At 1 day post‐ligation, the expression level of Sca‐1 was strongly increased in the experimental gland and weakly in the contralateral gland, and such expression in both glands decreased at 6 days. By immunohistochemistry, Sca‐1 was detected weakly in the apical membrane of excretory duct (ED) cells of the SMG under the normal condition. By duct ligation, Sca‐1 became expressed strongly in most cells of the two major duct systems, i.e.,... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4519171 Fri, 25 Feb 2011 00:00:00 +0100 4519171 Insulin‐like growth factor II mRNA‐binding protein 3 expression promotes tumor formation and invasion and predicts poor prognosis in oral squamous cell carcinoma http://www.medworm.com/index.php?rid=4519170&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01019.x Conclusions:  IGF2BP3 enhances cell invasion ability and tumorigenicity in human OSCC in vitro and in vivo. IGF2BP3 is an independent prognostic factor in patients with OSCC. Targeting of IGF2BP3 could potentially suppress the tumor growth and metastasis to improve the outcome of patients with OSCC. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4519170 Fri, 25 Feb 2011 00:00:00 +0100 4519170 Lubricin immunohistochemical expression in human temporomandibular joint disc with internal derangement http://www.medworm.com/index.php?rid=4519169&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01012.x J Oral Pathol Med (2011)Lubricin is a chondroprotective, mucinous glycoprotein which contribute to joint lubrication, especially to boundary lubrication and maintains joint integrity. The present investigation aimed to study the immunolocalization of lubricin in TMJ discs from patients affected by anterior disc displacement with reduction (ADDwR) ADDwoR. Eighteen TMJ displaced disc affected by ADDwoR were processed immunohistochemically, with a polyclonal anti‐lubricin antibody, used at 1:50 working dilution. The percentage of lubricin immunopositive cells (extent score = ES) and the extent of lubricin staining of the disc extracellular matrix (ECM), were evaluated. Each sample was scored for histopathological changes. Percentage of immunostained surface disc cells was the same (ES... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4519169 Fri, 25 Feb 2011 00:00:00 +0100 4519169 Tumour infiltrating CD25+ FoxP3+ regulatory T cells (Tregs) relate to tumour grade and stromal inflammation in oral squamous cell carcinoma http://www.medworm.com/index.php?rid=4514459&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01020.x J Oral Pathol Med (2011)This research is aimed to quantitate and characterize the subtypes of tumour infiltrating lymphocytes (TILs), in particular the presence of FoxP3+ Tregs in different grades of oral squamous cell carcinoma using monospecific antibody staining of formalin‐fixed, paraffin‐embedded tissue sections. The correlation between tumour grade and the intensity of tumour infiltrating lymphocytes was tried to be tested, to assume a putative linkage between them. Thirty‐four cases of histologically proven primary oral squamous cell carcinoma (OSCC) of different grades of differentiation were assorted to groups 1–3. Three‐micron sections of tissue were cut and captured on electrically charged slides (Vision BioSystem, Mount Waverley, Australia) and stained using monospeci... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4514459 Thu, 24 Feb 2011 20:22:56 +0100 4514459 Lentivirus‐mediated gene silencing of beta‐catenin inhibits growth of human tongue cancer cells http://www.medworm.com/index.php?rid=4514460&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01007.x Conclusions:  RNA interference (RNAi) targeting against beta‐catenin can induce cell growth suppression of tongue cancer and may have the potential as a therapeutic modality to treat human tongue cancer. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4514460 Thu, 24 Feb 2011 00:00:00 +0100 4514460 Prevalence of oral mucosal lesions and related factors in 200 HIV+/AIDS Iranian patients http://www.medworm.com/index.php?rid=4503933&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01013.x Conclusion:  With respect to the resulted prevalence in this study (74.5%), early detection of oral lesions must be emphasized on the diagnosis and early management of human immunodeficiency virus positive/acquired immune deficiency syndrome patients. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4503933 Tue, 22 Feb 2011 00:00:00 +0100 4503933 Distinct expression of perforin and granzyme B in lip and oral cavity squamous cell carcinoma http://www.medworm.com/index.php?rid=4503932&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01014.x Conclusions:  Perforin and GB proteins may contribute to antitumoural immunity, leading to the direct killing of tumour cells; however, it seems to occur more effectively in LSCC than OCSCC. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4503932 Tue, 22 Feb 2011 00:00:00 +0100 4503932 Markedly increased Oct4 and Nanog expression correlates with cisplatin resistance in oral squamous cell carcinoma http://www.medworm.com/index.php?rid=4503931&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01015.x Conclusions:  These data indicate that cancer stem‐like properties were expanded during the acquisition of cisplatin resistance in OSCC. Clinically, oral cancer stemness markers (Oct4 and Nanog) overexpression may promote the OSCC’s recurrence to resist cisplatin. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4503931 Tue, 22 Feb 2011 00:00:00 +0100 4503931 Autonomic nervous system in individuals with cerebral palsy: a controlled study http://www.medworm.com/index.php?rid=4485775&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01008.x Conclusion:  Individuals with cerebral palsy present cardiovascular changes principally manifested as disturbed sympathovagal balance. These autonomic dysfunctions could contribute to the salivary changes observed. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4485775 Wed, 16 Feb 2011 00:00:00 +0100 4485775 Nuclear β‐catenin expression in basal cell adenomas of salivary gland http://www.medworm.com/index.php?rid=4485774&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01010.x Conclusions:  We demonstrated nuclear β‐catenin expression and activation of the CTNNB1 gene in basal cell adenoma. Although nuclear β‐catenin expression may be unable to distinguish basal cell adenoma from basal cell adenocarcinoma, it should be a helpful marker in the diagnosis of basal cell adenoma. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4485774 Wed, 16 Feb 2011 00:00:00 +0100 4485774 Malignant transformation of oral verrucous leukoplakia: a clinicopathologic study of 53 cases http://www.medworm.com/index.php?rid=4503930&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01016.x Conclusion:  Clinicopathologic features of VL in China were elucidated. The utilization of age and lesion site at diagnosis as significant factors for evaluating malignant transformation risk in patients with VL was suggested. Further studies are required to investigate the roles of the potential risk factors in the VL malignant transformation. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4503930 Tue, 01 Feb 2011 00:00:00 +0100 4503930 HDAC2 promotes cell migration/invasion abilities through HIF‐1α stabilization in human oral squamous cell carcinoma http://www.medworm.com/index.php?rid=4491702&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01009.x Conclusions:  Our work demonstrates that HDAC2 maintains HIF‐1α stability, probably at the level of protein modification, which in turn leads to the increase in cell invasion/migration ability in oral cancer progression. These findings implicate the potential of HDAC inhibitors for oral cancer therapy. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4491702 Tue, 01 Feb 2011 00:00:00 +0100 4491702 Expression of host defence peptides in the lip vermilion mucosa during early infancy http://www.medworm.com/index.php?rid=4485773&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01018.x In conclusion, several HDPs are expressed at lower levels in infants, but not all. The results emphasize the need to adjust the dose of agents based on the specific HDP level for the treatment of infantile infections. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4485773 Tue, 01 Feb 2011 00:00:00 +0100 4485773 Helicobacter pylori in the oral cavity and gastric mucosa: a meta‐analysis http://www.medworm.com/index.php?rid=4437344&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2011.01006.x Conclusions:  There is a close relation between the infection of H. pylori in the oral cavity and stomach. H. pylori in the oral cavity are more difficult to be eradicated than in the stomach. It may be a source of reinfection. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4437344 Tue, 01 Feb 2011 00:00:00 +0100 4437344 Melatonin and cancer: current knowledge and its application to oral cavity tumours http://www.medworm.com/index.php?rid=4426070&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.01002.x Conclusions:  MLT contributes to protecting the oral cavity from tissue damage caused by receptor action. Experimental evidence suggests that it may be useful in the treatment and prognosis of tumour processes in the oral cavity. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4426070 Tue, 01 Feb 2011 00:00:00 +0100 4426070 miR‐221 and miR‐222 expression increased the growth and tumorigenesis of oral carcinoma cells http://www.medworm.com/index.php?rid=4346665&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.01005.x Conclusions:  Our findings suggested that increased miR‐221/miR‐222 expression was associated with the OSCC cell growth. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4346665 Thu, 13 Jan 2011 00:00:00 +0100 4346665 Overexpression of cdk4 and p16 in oral lichen planus supports the concept of premalignancy http://www.medworm.com/index.php?rid=4346667&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.01001.x Conclusion:  Oral lichen planus demonstrated overexpression of cdk4 and p16, but not cdk6, suggesting that epithelial cells in OLP are in the hyperproliferative state and in cell arrest. Altered expression of cdk4 and p16 provides evidence of the malignant potential in OLP. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4346667 Tue, 11 Jan 2011 00:00:00 +0100 4346667 Significance of myofibroblasts in oral squamous cell carcinoma http://www.medworm.com/index.php?rid=4346666&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00999.x J Oral Pathol Med (2011)It is now recognized that the tumor microenvironment makes significant contribution to tumor progression. Activated fibroblast endothelial cells, inflammatory cells, and various extra cellular matrix components are parts of this microenvironment. Most of the activated fibroblasts are α‐smooth muscle actin–positive myofibroblast that often represent the majority of tumor stromal cells. Their production of growth factors chemokines and extracellular matrix facilitates tumor growth. Myofibroblast have been demonstrated in close to 50% of oral squamous cell carcinomas. In this review, we highlight the histological distribution of myofibroblast in oral squamous cell and the myofibroblast relation to tumor growth on prognosis. (Source: Journal of Oral Pathology and M... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4346666 Tue, 11 Jan 2011 00:00:00 +0100 4346666 Vascular endothelial growth factor genetic polymorphisms and haplotypes in female patients with bisphosphonate‐related osteonecrosis of the jaws http://www.medworm.com/index.php?rid=4374395&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.01004.x Conclusions:  These results suggest a possible haplotype effect of VEGF polymorphisms expression in BRONJ Italian female patients. Studies with different and larger populations possibly using TagSNP to represent all haplotypes within the VEGF gene are needed to further delineate the genetic contribution of this gene to BRONJ. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4374395 Sat, 01 Jan 2011 00:00:00 +0100 4374395 miR‐181 as a putative biomarker for lymph‐node metastasis of oral squamous cell carcinoma http://www.medworm.com/index.php?rid=4365496&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.01003.x Conclusion: miR‐181 may enhance lymph‐node metastasis through regulating migration, which could potentially be exploited as a putative biomarker for patients with OSCC. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4365496 Sat, 01 Jan 2011 00:00:00 +0100 4365496 Ras gene mutation is not related to tumour invasion during rat tongue carcinogenesis induced by 4‐nitroquinoline 1‐oxide http://www.medworm.com/index.php?rid=4346664&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00987.x Conclusions:  Our results support the idea that expression of Ki‐67 plays a crucial role during malignant transformation being closely related to neoplastic conversion of the oral mucosa cells. However, it seems that mutations in the ras genes are not involved to experimental tongue carcinogenesis induced by 4NQO. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4346664 Sat, 01 Jan 2011 00:00:00 +0100 4346664 Oral leukoplakias with different degrees of dysplasia: comparative study of hMLH1, p53, and AgNOR http://www.medworm.com/index.php?rid=4311175&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.01000.x Conclusions:  Alterations in the immunoexpression pattern of hMLH1 and p53 seemed to be early events in oral carcinogenesis. During acquisition of a more dysplastic phenotype, keratinocytes may show diminished capacity of DNA repair and tumor suppression, as well as higher cellular proliferation, and these pathways can be somehow interconnected. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4311175 Sat, 01 Jan 2011 00:00:00 +0100 4311175 Differential expression of perlecan receptors, α‐dystroglycan and integrin β1, before and after invasion of oral squamous cell carcinoma http://www.medworm.com/index.php?rid=4299569&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00990.x Conclusion:  The findings suggest that α‐dystroglycan and integrin β1 act as perlecan receptors in oral precancerous lesions prior to invasion, and that the perlecan signals via the two different receptors function in cellular differentiation and proliferation of CIS cells, respectively. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4299569 Thu, 30 Dec 2010 00:00:00 +0100 4299569 Lycopene: features and potential significance in the oral cancer and precancerous lesions http://www.medworm.com/index.php?rid=4299568&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00991.x J Oral Pathol Med (2010)Data from epidemiological studies have indicated that diets rich in fruits and vegetables are likely to benefit many aspects of the prevention of oral malignancy. Lycopene is a red‐coloured carotenoid predominantly accumulated in tomatoes as well as other fruits and vegetables. It has been claimed to alleviate chronic diseases such as cancers and cardiovascular disease. Hence, the aim of this review is to summarize the features and its potential significance of lycopene in the development, prevention and treatment of oral premalignant lesions and oral cancer. Studies showed that lycopene might have beneficial effects in the management of some premalignant lesions in the oral cavity including oral submucous fibrosis and oral leukoplakia and may be an adjunct in the... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4299568 Thu, 30 Dec 2010 00:00:00 +0100 4299568 Mastocytosis: oral implications of a rare disease http://www.medworm.com/index.php?rid=4299567&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00996.x J Oral Pathol MedMastocytosis encompasses a group of rare clinical entities, which are characterized by an abnormal growth and, usually, low accumulation of clonal and morphologically abnormal mast cells (MCs), within one or more organs. Clinical presentations are quite variable and symptoms are usually related to the release of mast cell mediators, tissue infiltration by MC (usually in the aggressive categories of the disease), or both. Mast cells are hematopoietic‐derived cells that reach phenotypic maturity in the mucosa and peripheral connective tissues. These cells play an active role both on immunologic and non‐immunologic processes. Within the oral cavity, MCs reside in the connective tissues, in physiologic conditions, and their number is elevated in pathologic situations resul... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4299567 Thu, 30 Dec 2010 00:00:00 +0100 4299567 Evidence for a possible anatomical subsite–mediated effect of tobacco in oral potentially malignant disorders and carcinoma http://www.medworm.com/index.php?rid=4290680&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00984.x Conclusions:  The association of smoking and age suggests that smoking may contribute to generate a field of injury that leads to lesions in shorter periods than other causes. The stronger relationship of smoking with lesions in the buccal mucosa and FOM than in the tongue suggests that tissue characteristics mediate the effects of tobacco. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4290680 Tue, 28 Dec 2010 00:00:00 +0100 4290680 The effectiveness of systemic eradication therapy against oral Helicobacter pylori http://www.medworm.com/index.php?rid=4290679&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00989.x Conclusion:  Almost half of the patients with gastric H. pylori harbored the bacterium in the oral cavity. After the eradication therapy, H. pylori was not detected in the oral cavity, what suggests high effectiveness of the therapy protocol in the oral cavity, or it is possible that oral H. pylori is of a transient character. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4290679 Tue, 28 Dec 2010 00:00:00 +0100 4290679 Immunoexpression of MMP‐9, VEGF, and vWF in central and peripheral giant cell lesions of the jaws http://www.medworm.com/index.php?rid=4290678&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00993.x Conclusions:  MMP‐9 and VEGF might play an important role in the osteoclastogenesis process in CGCL. The higher MVC in PGCL might be related to the reactive nature of these lesions. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4290678 Tue, 28 Dec 2010 00:00:00 +0100 4290678 Folic acid rescue of ATRA‐induced cleft palate by restoring the TGF‐β signal and inhibiting apoptosis http://www.medworm.com/index.php?rid=4286511&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00994.x Conclusions:  Folic acid can rescue the cultured palates to continue developing and fusing that were inhibited and resulted in cleft palate by ATRA. Apoptosis and TGFβ signaling in MEPM cells were involved in folic acid rescued ATRA‐induced cleft palate. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4286511 Fri, 24 Dec 2010 00:00:00 +0100 4286511 Transfection of truncated bone morphogenetic protein receptor‐II into oral squamous cell carcinoma cell line Tca8113 and inhibitory effect on proliferation and inductive effect on apoptosis http://www.medworm.com/index.php?rid=4286510&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00988.x In this study, a negative truncated mutant of the BMP receptor‐II (tBMPR‐II) was transfected into Tca8113 cells. The effects were evaluated though RT‐PCR, 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyltetrazolium bromide (MTT) assay, BrdU staining, cell cyclin assay, TdT‐mediated dUTP nick end labeling (TUNEL) staining, and cell cycle protein detection. Overexpression of tBMPR‐II gene transfection truncates the expression of BMPR‐II mRNA expression, but not BMP 2, 4, 5. tBMPR‐II resulted in a remarkable inhibition of cell proliferation and viability compared with control Tca8113. The inhibitory effects were partly attributed to the induction of apoptosis and cell cycle arrest in G0/G1 accompanied by downregulation of the intracellular cell cycle proteins of cyclin D1 a... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4286510 Fri, 24 Dec 2010 00:00:00 +0100 4286510 The use of toluidine blue in the detection of pre‐malignant and malignant oral lesions http://www.medworm.com/index.php?rid=4286509&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00985.x Conclusions:  The simplicity of the test procedure and the validity of derived values suggest TB staining can be a valuable adjunct to the diagnostic process, as long as it is carefully correlated with the clinical characteristics of the mucosal disorder and histopathological diagnosis. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4286509 Fri, 24 Dec 2010 00:00:00 +0100 4286509 Cyclooxygenase‐2 expression in oral tongue squamous cell carcinoma http://www.medworm.com/index.php?rid=4286508&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00992.x Conclusion:  Cyclooxygenase‐2 expression has limited prognostic value in OTSCC. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4286508 Fri, 24 Dec 2010 00:00:00 +0100 4286508 Analysis of differentially expressed proteins in oral squamous cell carcinoma by MALDI‐TOF MS http://www.medworm.com/index.php?rid=4269223&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00982.x Conclusion:  We identified six proteins which are differentially expressed in most OSCC compared to healthy tissues. Of those, by string analysis, multiple interaction partners are assumed for hsp70. This protein is supposed to be the most promising candidate as marker molecule and target for OSCC therapy. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4269223 Fri, 17 Dec 2010 00:00:00 +0100 4269223 Candida glabrata and Candida albicans co‐infection of an in vitro oral epithelium http://www.medworm.com/index.php?rid=4261463&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00981.x Conclusions:  The results obtained demonstrating enhanced invasion and increased tissue damage caused by mixed C. glabrata and C. albicans infections have important clinical significance and highlight the need to identify Candida species involved in oral candidosis. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4261463 Wed, 15 Dec 2010 00:00:00 +0100 4261463 Stem cell characteristics of cell sub‐populations in cell lines derived from head and neck cancers of Fanconi anemia patients http://www.medworm.com/index.php?rid=4239734&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00972.x J Oral Pathol Med (2010)Increasing evidence indicates that cancer growth is driven by a sub‐population of self‐renewing cancer stem cells (CSCs) and that clinical problems of tumor recurrence after therapy may be related to differential resistance of CSCs to therapeutic elimination. Fanconi anemia (FA) is an autosomal recessive disorder associated with deficiencies of DNA repair and a greatly enhanced risk of hematopoietic malignancies and of head and neck squamous cell carcinoma (HNSCC). In FA patients, lack of DNA repair complicates therapies acting through DNA damage and alternative approaches, such as targeting signaling pathways associated with stem cell maintenance, might be of particular benefit. To assess effects of FA gene defects on the expression of stem cell properties, CSC... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4239734 Wed, 08 Dec 2010 00:00:00 +0100 4239734 5‐aminolevulinic acid induce apoptosis via NF‐κB/JNK pathway in human oral cancer Ca9–22 cells http://www.medworm.com/index.php?rid=4239733&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00973.x Conclusion:  These results demonstrate significant involvement of caspase‐8 and ‐9 and their upstream NF‐κB‐JNK pathways in ALA‐PDT‐induced apoptosis. Future studies on how NF‐κB and JNK activity regulate ALA‐PDT response should provide a better strategy for the treatment of oral cancer. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4239733 Wed, 08 Dec 2010 00:00:00 +0100 4239733 Evidence of loss of heterozygosity of the PTCH gene in orthokeratinized odontogenic cyst http://www.medworm.com/index.php?rid=4239732&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00977.x J Oral Pathol Med (2010)The orthokeratinized odontogenic cyst (OOC) is an odontogenic cyst of unknown etiology. Clinical, histological, and biological differences are reported between keratocystic odontogenic tumor (KOT) and OOC. PTCH is a tumor suppressor gene related to sonic hedgehog (SHH) pathway important in embryological development. Considering that alterations in this pathway have been described in sporadic and nevoid basal cell syndrome‐associated KOT, we tested the hypothesis that OOC is also associated with loss of heterozygosity (LOH) of the PTCH gene. Seven samples of OOC and seven of KOT were included in the study. D9S287, D9S196, and D9S127 microsatellite markers located in the region of PTCH gene, at chromosome 9q, were investigated for LOH. There was loss in at least one... Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4239732 Wed, 08 Dec 2010 00:00:00 +0100 4239732 Areca nut extract upregulates vimentin by activating PI3K/AKT signaling in oral carcinoma http://www.medworm.com/index.php?rid=4239731&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00978.x Conclusion:  Our results imply that PI3K/AKT activation and vimentin expression are important pathogenic cascades in areca‐associated oral carcinogenesis. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4239731 Wed, 08 Dec 2010 00:00:00 +0100 4239731 Vascular endothelial growth factor and thymidine phosphorylase expression in salivary gland tumors with distinct metastatic behavior http://www.medworm.com/index.php?rid=4239730&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00980.x Conclusions:  Vascular endothelial growth factor and TP expression levels discriminate benign and malignant tumors but cannot predict metastasis from non‐metastasizing tumors. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4239730 Wed, 08 Dec 2010 00:00:00 +0100 4239730 Cancer stem cell immunophenotypes in oral squamous cell carcinoma http://www.medworm.com/index.php?rid=4169874&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00967.x Conclusions:  Based on our results, the CD44 immunostaining and the absence of immunoexpression of these two investigated markers can be used in combination with other clinicopathologic information to improve the assessment of prognosis in OSCC. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4169874 Mon, 15 Nov 2010 00:00:00 +0100 4169874 Multiple calcifying hyperplastic dental follicles: comparison with hyperplastic dental follicles http://www.medworm.com/index.php?rid=4146571&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00968.x Conclusions:  This study indicates that MCHDF is a separate pathologic entity with exclusive male predilection and earlier calcifications, different to HDF. Further studies are needed to understand the etiology of MCHDFs to provide various options for treatment, and to clarify the mechanisms of eruption. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4146571 Tue, 09 Nov 2010 00:00:00 +0100 4146571 Metallothionein in the radicular, dentigerous, orthokeratinized odontogenic cysts and in keratocystic odontogenic tumor http://www.medworm.com/index.php?rid=4146570&cid=s_28436_32_f&fid=28436&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0714.2010.00971.x Conclusions:  The higher IMT found in RC and DC compared to OCC and KOT, as well as the differences between the last ones, is possibly correlated with their different histopathological features and clinical behavior. In RC and DC, MT may play a role in cellular proliferation. However, it seems that MT is either less or is not related to proliferation in OOC and in KOT. Moreover, inflammation does not seem to alter IMT and IK. (Source: Journal of Oral Pathology and Medicine) Journal of Oral Pathology and Medicine journals http://www.medworm.com/rss/comments.php?id=4146570 Tue, 09 Nov 2010 00:00:00 +0100 4146570