Journal of Periodontal Research via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Periodontal Research' source. Sat, 20 Mar 2010 14:02:02 +0100 A novel molecule, SLURP-1, enhances the survival of periodontal ligament fibroblasts http://www.medworm.com/index.php?rid=3343901&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01240.x Conclusion: These findings suggest that SLURP-1 may play an important role in the control and maintenance of the periodontal ligament by protecting the periodontal ligament fibroblasts from apoptosis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343901 Tue, 09 Mar 2010 00:00:00 +0100 3343901 Periodontitis-specific molecular signatures in gingival crevicular fluid http://www.medworm.com/index.php?rid=3343900&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01243.x Conclusion: We have established that mid-infrared spectroscopy can be used to identify periodontitis-specific molecular signatures in gingival crevicular fluid and to confirm clinical diagnoses. Future longitudinal studies will assess whether mid-infrared spectroscopy represents a potential prognostic tool, recognized as key to advancement of periodontics. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343900 Tue, 09 Mar 2010 00:00:00 +0100 3343900 Periodontal inflammation and bone loss in aged mice http://www.medworm.com/index.php?rid=3343899&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01245.x Conclusion: Mice develop naturally induced periodontal bone loss as a function of age. This aging model of periodontitis represents a genuinely chronic model to study mechanisms of periodontal tissue destruction. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343899 Tue, 09 Mar 2010 00:00:00 +0100 3343899 Major surface protein complex of Treponema denticola induces the production of tumor necrosis factor α, interleukin-1β, interleukin-6 and matrix metalloproteinase 9 by primary human peripheral blood monocytes http://www.medworm.com/index.php?rid=3343898&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01246.x Conclusion: These results indicate that T. denticola MSPc, at concentrations ranging from 100 ng/mL to 1.0 [mu]g/mL, activates a proinflammatory response in primary human monocytes. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343898 Tue, 09 Mar 2010 00:00:00 +0100 3343898 Heme oxygenase-1 protects human periodontal ligament cells against substance P-induced RANKL expression http://www.medworm.com/index.php?rid=3343897&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01247.x Conclusion: These results suggest that SP stimulates osteoclastic differentiation by increasing the expression of RANKL vs. OPG via the HO-1 pathway in periodontal ligament cells. The HO-1 pathway may be an effective therapeutic target for inhibiting chronic periodontitis involving alveolar bone resorption. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343897 Tue, 09 Mar 2010 00:00:00 +0100 3343897 In vitro engineering of complete autologous oral mucosa equivalents: characterization of a novel scaffold http://www.medworm.com/index.php?rid=3343896&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01248.x Conclusions: It is possible to engineer a CAOME with an epithelium of basal-like and immature keratinocytes, which could potentially reconstruct in vivo loss of tissue. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343896 Tue, 09 Mar 2010 00:00:00 +0100 3343896 Porphyromonas gingivalis stimulates the release of nitric oxide by inducing expression of inducible nitric oxide synthases and inhibiting endothelial nitric oxide synthases http://www.medworm.com/index.php?rid=3343895&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01249.x Conclusion: Our study provides evidence that P. gingivalis ATCC 33277 can invade HUVECs, and the ability of P. gingivalis ATCC 33277 to promote the production of NO may be important in endothelial dysfunction, suggesting that P. gingivalis ATCC 33277may be one of the pathogens responsible for atherosclerosis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343895 Tue, 09 Mar 2010 00:00:00 +0100 3343895 Profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time PCR http://www.medworm.com/index.php?rid=3343894&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01250.x Conclusion: Obligate anaerobes, including T. forthysia, P. gingivalis and E. saphenum, were identified predominantly in microflora from subjects with periodontitis, whereas Streptococcus species were identified predominantly in microflora from periodontally healthy subjects, suggesting a change in the subgingival environment that resulted in conditions more suitable for the survival of obligate anaerobes. The proportion of these obligate anaerobes in the subgingival plaque of subjects with periodontitis appears to be associated with the status of human periodontitis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343894 Tue, 09 Mar 2010 00:00:00 +0100 3343894 The del/del genotype of the nuclear factor-κB -94ATTG polymorphism and its relation to aggressive periodontitis http://www.medworm.com/index.php?rid=3343893&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01251.x Conclusions: The del/del genotype of NF-[kappa]B was shown to be associated with the occurrence of aggressive periodontitis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343893 Tue, 09 Mar 2010 00:00:00 +0100 3343893 Significance of elevated gingival crevicular fluid tumor necrosis factor-α and interleukin-8 levels in chronic hemodialysis patients with periodontal disease http://www.medworm.com/index.php?rid=3343892&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01252.x Conclusion: The levels of TNF-[alpha] and IL-8 in gingival crevicular fluid were significantly higher in HD patients than in controls. There were strong, positive correlations between clinical periodontal parameters and the levels of inflammatory cytokines in gingival crevicular fluid from the HD patients. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343892 Tue, 09 Mar 2010 00:00:00 +0100 3343892 Effects of areca nut extract on the apoptosis pathways in human neutrophils http://www.medworm.com/index.php?rid=3343891&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01253.x Conclusion: Areca nut may regulate death pathways in neutrophils. This may be one mechanism by which areca nut compromises the periodontal health of areca nut chewers. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343891 Tue, 09 Mar 2010 00:00:00 +0100 3343891 Effects of epidermal growth factor and/or nerve growth factor on Malassez's epithelial rest cells in vitro: expression of mRNA for osteopontin, bone morphogenetic protein 2 and vascular endothelial growth factor http://www.medworm.com/index.php?rid=3343890&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01254.x Conclusion: EGF and NGF play important roles in maintaining the PDL. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343890 Tue, 09 Mar 2010 00:00:00 +0100 3343890 Flutamide inhibits nifedipine- and interleukin-1β-induced collagen overproduction in gingival fibroblasts http://www.medworm.com/index.php?rid=3343889&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01255.x Conclusion: The data suggest that both nifedipine and interleukin-1[beta] play an important role in DIGO via androgen receptor upregulation and that gingival overgrowth is mainly due to collagen accumulation. Flutamide decreases the gene expression and protein production of collagen from dihydropyridine-induced overgrowth cells. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343889 Tue, 09 Mar 2010 00:00:00 +0100 3343889 Adenosine triphosphate stimulates RANKL expression through P2Y1 receptor–cyclo-oxygenase-dependent pathway in human periodontal ligament cells http://www.medworm.com/index.php?rid=3343888&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01256.x Conclusion: Extracellular ATP stimulates RANKL expression in human periodontal ligament cells through a pathway dependent on the P2Y1 receptor, cAMP-dependent protein kinase, NF[kappa]B and COX. Our results suggest that, among the molecules responsible for the effect of mechanical stress, ATP participates in bone resorption or bone homeostasis by mediating its signal through the P2Y1 receptor and the NF[kappa]B[ndash]COX[ndash]RANKL axis in periodontal tissue. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343888 Tue, 09 Mar 2010 00:00:00 +0100 3343888 Myeloid-related protein (MRP8/14) expression in gingival crevice fluid in periodontal health and disease and after treatment http://www.medworm.com/index.php?rid=3343887&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01257.x Andersen E, Dessaix IM, Perneger T, Mombelli A. Myeloid-related protein (MRP8/14) expression in gingival crevice fluid in periodontal health and disease and after treatment. J Periodont Res 2010; doi: 10.1111/j.1600-0765.2009.01257.x. © 2010 John Wiley & Sons A/SBackground and Objective: Myeloid-related protein (MRP8/14) and its subunits are biomarkers of inflammation. The present study evaluated whether gingival crevice fluid levels of these markers discriminate periodontitis from healthy sites in patients with chronic periodontitis or diseased from healthy subjects, and whether these biomarkers detect longitudinal changes after therapy.Material and Methods: Levels of MRP8/14, MRP14 and total protein were quantified in 19 periodontitis patients before non-surgical periodontal therapy, af... Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343887 Tue, 09 Mar 2010 00:00:00 +0100 3343887 The expressions of claudin-1 and E-cadherin in junctional epithelium http://www.medworm.com/index.php?rid=3343886&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01258.x Conclusion: These data suggest that claudin-1 and E-cadherin exist in the junctional epithelium and may play an important role in epithelial barrier function. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343886 Tue, 09 Mar 2010 00:00:00 +0100 3343886 Human β-defensin-3 up-regulates cyclooxygenase-2 expression and prostaglandin E2 synthesis in human gingival fibroblasts http://www.medworm.com/index.php?rid=3343885&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01259.x Conclusion: These findings indicate that epithelial human [beta]-defensin-3 functions as a proinflammatory mediator in controlling arachidonic acid metabolism in underlying fibroblasts. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343885 Tue, 09 Mar 2010 00:00:00 +0100 3343885 Immune response to cytolethal distending toxin of Aggregatibacter actinomycetemcomitans in periodontitis patients http://www.medworm.com/index.php?rid=3343884&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01260.x Conclusion: Response to CdtA and CdtB did not correlate with the periodontal status of the subject in the context of an A. actinomycetemcomitans infection. However, a response to CdtC was found in sera of generalized but not of localized aggressive periodontitis subjects. Differences in response to CdtC between generalized and localized aggressive periodontitis subjects indicate that CDT could be expressed differently by the infecting strains. Alternatively, the antibody response to CdtC could require the colonization of multiple sites. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343884 Tue, 09 Mar 2010 00:00:00 +0100 3343884 Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells http://www.medworm.com/index.php?rid=3343883&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01261.x Conclusion: These data show that a proapoptotic fibronectin matrix induces ubiquitination and degradation of p53 in the proteasome as part of a novel mechanism of apoptosis associated with inflammatory diseases. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343883 Tue, 09 Mar 2010 00:00:00 +0100 3343883 Interleukin-1 and interleukin-8 in nicotine- and lipopolysaccharide-exposed gingival keratinocyte cultures http://www.medworm.com/index.php?rid=3343882&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01262.x Conclusion: These results demonstrate that nicotine and LPS differentially regulate IL-1 and IL-8 production by gingival keratinocytes. Combined treatment tended to elevate cytokine production further, which may have implications for the progression of periodontitis in tobacco users. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=3343882 Tue, 09 Mar 2010 00:00:00 +0100 3343882 Gingival crevicular fluid can degrade Emdogain and inhibit Emdogain-induced proliferation of periodontal ligament fibroblasts http://www.medworm.com/index.php?rid=2974885&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01244.x Conclusion: We suggest that diseased gingival crevicular fluid containing various proteases leads to degradation of EMD and decreased proliferation of periodontal ligament fibroblasts. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2974885 Tue, 10 Nov 2009 00:00:00 +0100 2974885 Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via extracellular signal-regulated kinase http://www.medworm.com/index.php?rid=2974894&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01218.x Conclusion: These data suggest that EMD may affect gingival health by ways other than cell proliferation/survival, i.e. by stimulation of TIMP-3 production, which could improve the MMP[ndash]TIMP balance in gingival tissue and curb extracellular matrix destruction. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2974894 Mon, 09 Nov 2009 00:00:00 +0100 2974894 Systematic review on the effect of rinsing with povidone-iodine during nonsurgical periodontal therapy http://www.medworm.com/index.php?rid=2974893&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01232.x Conclusion: The adjunctive use of PVP-iodine during scaling and root planing may increase the clinical pocket depth reduction, although the clinical significance is small to moderate. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2974893 Mon, 09 Nov 2009 00:00:00 +0100 2974893 Single nucleotide polymorphisms of complement component 5 and periodontitis http://www.medworm.com/index.php?rid=2974892&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01234.x Conclusion: The tagging SNP rs17611 of the C5 gene and smoking may be associated with periodontitis among the Hong Kong Chinese population. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2974892 Mon, 09 Nov 2009 00:00:00 +0100 2974892 The adjunctive use of platelet-rich plasma in the therapy of periodontal intraosseous defects: a systematic review http://www.medworm.com/index.php?rid=2974891&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01236.x Conclusion: Diverse outcomes (positive and negative) have been reported for the efficacy of PRP combined with various therapeutic bioactive agents/procedures, reflecting the limited and heterogeneous data available and possibly suggesting that the specific selection of agents/procedures combined with PRP could be important. Additional research on the efficacy of each specific combination of PRP is necessary. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2974891 Mon, 09 Nov 2009 00:00:00 +0100 2974891 Induction of MMP-2 at the interface between epithelial cells and fibroblasts from human periodontal ligament http://www.medworm.com/index.php?rid=2974890&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01237.x Conclusion: These findings indicate that putative epithelial rests of Malassez cells stimulate the production of MMP-2 in human periodontal ligament fibroblasts. Up-regulated proMMP-2 bound by MMP-14 expressed in epithelial rests of Malassez cells can degrade matrix molecules, such as type IV collagen, in the basal membrane between putative epithelial rests of Malassez cells and human periodontal ligament fibroblasts. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2974890 Mon, 09 Nov 2009 00:00:00 +0100 2974890 The upregulation of heat shock protein 47 in human gingival fibroblasts stimulated with cyclosporine A http://www.medworm.com/index.php?rid=2974889&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01238.x Conclusion: Expression of Hsp47 is significantly upregulated in cyclosporine A-induced gingival overgrowth specimens, and Hsp47 expression induced by cyclosporine A in fibroblasts may be mediated by the MEK signal transduction pathway. The expression of Hsp47 could be significantly enhanced by A. actinomycetemcomitans and interlukin-1[alpha]. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2974889 Mon, 09 Nov 2009 00:00:00 +0100 2974889 Expression of heat shock proteins, Hsp70 and Hsp25, in the rat gingiva after irradiation with a CO2 laser in coagulation mode http://www.medworm.com/index.php?rid=2974888&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01239.x Conclusion: The CO2 laser treatment in coagulation mode produced the expression of heat shock proteins, and the findings suggest that while Hsp70 mainly conferred cell protection, Hsp25 was involved in the progress of wound repair as well as cell protection. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2974888 Mon, 09 Nov 2009 00:00:00 +0100 2974888 Co-purified gelatinases alter the stability and biological activities of human plasma fibronectin preparations http://www.medworm.com/index.php?rid=2974887&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01241.x Conclusion: The present experiments devised a time- and cost-efficient protocol for eliminating gelatinases during purification of human plasma FN. Gelatinase-free FN preparations had greater stability, which may be essential for experiments because FN fragments have altered biological activities compared with intact FN. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2974887 Mon, 09 Nov 2009 00:00:00 +0100 2974887 Molecular analysis of aortic intimal hyperplasia caused by Porphyromonas gingivalis infection in mice with endothelial damage http://www.medworm.com/index.php?rid=2974886&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01242.x Conclusion: We found that bacteremia induced by P. gingivalis leads to intimal hyperplasia associated with overexpressions of S100A9 and SMemb. Our results strongly suggest that oral[ndash]hematogenous spreading of P. gingivalis is a causative event in the development of aortic hyperplasia in periodontitis patients. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2974886 Mon, 09 Nov 2009 00:00:00 +0100 2974886 Expression of receptor activator of nuclear factor κB ligand in ligature-induced periodontitis in osteoporotic and non-osteoporotic rats http://www.medworm.com/index.php?rid=2821784&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01210.x Conclusion: The increased bone loss observed in group 4 compared with either group 2 or group 3 supports the existence of an additive pathological effect of the two disease conditions. This is consistent with the increased RANKL expression observed in group 4. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2821784 Tue, 22 Sep 2009 23:00:00 +0100 2821784 Analysis of matrix metalloproteinase (MMP-8 and MMP-2) activity in gingival crevicular fluid from children with Down's syndrome http://www.medworm.com/index.php?rid=2821783&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01214.x Conclusion: These results suggest an increase in MMP-2 and MMP-8 in Down's syndrome patients, regardless of whether inflammation of periodontal tissue is present or not. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2821783 Tue, 22 Sep 2009 23:00:00 +0100 2821783 Short-term induction of thrombocytopenia delays periodontal healing in rats with periodontal disease: participation of endostatin and vascular endothelial growth factor http://www.medworm.com/index.php?rid=2821782&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01216.x Conclusion: Thrombocytopenia leads to a delay of periodontal healing in the situation of experimental periodontitis, which might be mediated in part by a decrease in the serum concentration of VEGF and endostatin derived from the platelets. However, other factors derived from the platelets may also have contributed to a delay of periodontal healing in the rats with thrombocytopenia. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2821782 Tue, 22 Sep 2009 23:00:00 +0100 2821782 Changes in cell characteristics due to retinoic acid; specifically, a decrease in the expression of claudin-1 and increase in claudin-4 within tight junctions in stratified oral keratinocytes http://www.medworm.com/index.php?rid=2821781&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01219.x Conclusion: Retinoic acid changed the expression of tight junction constituent molecules, such as claudin-1 and claudin-4, in oral keratinocytes. These findings suggest that long-term application of retinoids in clinical therapy should be carefully performed. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2821781 Tue, 22 Sep 2009 23:00:00 +0100 2821781 Periodontitis as a risk factor for cerebrovascular accident: a case–control study in the Indian population http://www.medworm.com/index.php?rid=2821780&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01220.x Conclusion: The data from this study support the proposed link between periodontitis and cerebrovascular accident in the Indian population. However, further studies are necessary to verify and quantify the role of oral infections and genetic factors in the process of atherosclerosis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2821780 Tue, 22 Sep 2009 23:00:00 +0100 2821780 Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with gingival overgrowth http://www.medworm.com/index.php?rid=2821779&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01221.x Conclusion: No association between MMP-3 gene polymorphism and gingival overgrowth was revealed in kidney transplant patients administered cyclosporine A. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2821779 Tue, 22 Sep 2009 23:00:00 +0100 2821779 Influence of serum on interaction of Porphyromonas gingivalis ATCC 33277 and Aggregatibacter actinomycetemcomitans Y4 with an epithelial cell line http://www.medworm.com/index.php?rid=2821778&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01224.x Conclusion: Serum promotes the release of the cytokines IL-6 and IL-8 by epithelial cells. This mechanism is influenced by periodontal pathogens and may maintain clinical periodontal inflammation. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2821778 Tue, 22 Sep 2009 23:00:00 +0100 2821778 Enhanced monocyte migration and pro-inflammatory cytokine production by Porphyromonas gingivalis infection http://www.medworm.com/index.php?rid=2821777&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01225.x Conclusion: Since monocyte recruitment and activation are important steps in the development of vascular inflammation and atherosclerosis, these results suggest that P. gingivalis infection may be involved in these processes. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2821777 Tue, 22 Sep 2009 23:00:00 +0100 2821777 Detection of oxidized low-density lipoproteins in gingival crevicular fluid from dental patients http://www.medworm.com/index.php?rid=2821776&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01226.x Conclusion: This is the first report to show the presence of apolipoprotein B and apolipoprotein B[ndash] oxidized phosphatidylcholine complex, which correspond to LDL and OxLDL, respectively, in gingival crevicular fluid. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2821776 Tue, 22 Sep 2009 23:00:00 +0100 2821776 Localization of SOST/sclerostin in cementocytes in vivo and in mineralizing periodontal ligament cells in vitro http://www.medworm.com/index.php?rid=2821775&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01227.x Conclusion: The identification of SOST/sclerostin in cementocytes and mineralizing periodontal ligament cells adds to our understanding of the biology of the periodontium, but the functional meaning of these findings can only be unravelled after additional in vitro and in vivo studies. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2821775 Tue, 22 Sep 2009 23:00:00 +0100 2821775 Effects of N-acyl homoserine lactone analogues on Porphyromonas gingivalis biofilm formation http://www.medworm.com/index.php?rid=2821774&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01228.x Conclusion: Three synthetic N-acyl HSL analogues inhibited biofilm formation in P. gingivalis. We suggest that these analogues influence the development stage of P. gingivalis biofilm formation. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2821774 Tue, 22 Sep 2009 23:00:00 +0100 2821774 Gingival and periodontal ligament fibroblasts differ in their inflammatory response to viable Porphyromonas gingivalis http://www.medworm.com/index.php?rid=2821773&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01229.x Conclusion: Considerable heterogeneity in responsiveness to P. gingivalis exists both between GF and PDLF and between individuals, which may be crucial determinants for the susceptibility to develop periodontitis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2821773 Tue, 22 Sep 2009 23:00:00 +0100 2821773 Overeruption of periodontally affected unopposed molars in adult rats http://www.medworm.com/index.php?rid=2821772&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01230.x Conclusion: The loss of antagonist causes overeruption of the unopposed tooth, which becomes more prominent in the presence of periodontitis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2821772 Tue, 22 Sep 2009 23:00:00 +0100 2821772 Relationship of smoking and smoking cessation with oral health status in Japanese men http://www.medworm.com/index.php?rid=2779817&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01233.x Conclusion: Smoking has a positive association with missing teeth and periodontitis. However, smoking cessation is beneficial for oral health. The odds of having more than eight missing teeth, or of having periodontitis, in those who had never smoked was similar to that of individuals who reported that they had stopped smoking for 11 years or more. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2779817 Wed, 09 Sep 2009 23:00:00 +0100 2779817 Effects of topical application of lipopolysaccharide and proteases on hepatic injury induced by high-cholesterol diet in rats http://www.medworm.com/index.php?rid=2581936&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01212.x Conclusion: In a rat model, application of lipopolysaccharide and proteases to the gingival sulcus augmented the effect of a high-cholesterol diet on steatosis, inflammation and oxidative damage in the liver. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581936 Wed, 08 Jul 2009 23:00:00 +0100 2581936 The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms http://www.medworm.com/index.php?rid=2581957&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01187.x Conclusion: Oral bacteria in biofilms are affected less by photodynamic therapy than bacteria in the planktonic phase. The antibacterial effect of photodynamic therapy is reduced in biofilm bacteria but not to the same degree as has been reported for treatment with antibiotics under similar conditions. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581957 Tue, 07 Jul 2009 23:00:00 +0100 2581957 Up-regulation of osteolytic mediators in human osteosarcoma cells stimulated with nicotine http://www.medworm.com/index.php?rid=2581956&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01188.x Conclusion: Taken together, the results of the present study indicated that smoking modulation of bone destruction in periodontal disease may involve various osteolytic mediators, such as interleukin-1, interleukin-8, RANKL, MMP-2, MMP-9, and tissue-type plasminogen activator. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581956 Tue, 07 Jul 2009 23:00:00 +0100 2581956 Osteoprotegerin induces osteopontin via syndecan-1 and phosphoinositol 3-kinase/Akt in human periodontal ligament cells http://www.medworm.com/index.php?rid=2581955&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01190.x Conclusion: An increased level of osteoprotegerin can generate signals via a RANKL/syndecan-1/phosphoinositol 3-kinase/Akt pathway. The results also suggest that osteopontin is one of the downstream targets of the pathway mediated by osteoprotegerin in human periodontal ligament cells. Thus, in addition to counteracting RANKL in the RANKL[ndash]osteoprotegerin system, osteoprotegerin may play a role in periodontal tissue remodeling through modulation of the extracellular matrix. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581955 Tue, 07 Jul 2009 23:00:00 +0100 2581955 Expression of matrix metalloproteinase-1, matrix metalloproteinase-2 and extracellular metalloproteinase inducer in human periodontal ligament cells stimulated with interleukin-1beta http://www.medworm.com/index.php?rid=2581954&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01191.x Conclusion: Interleukin-1beta up-regulated the levels of MMP-1 and MMP-2, but it did not alter the expression of extracellular MMP inducer. Expression of MMP-1 and MMP-2 might be elevated by interleukin-1beta and extracellular MMP inducer via two different signal pathways. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581954 Tue, 07 Jul 2009 23:00:00 +0100 2581954 Regulation of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases by basic fibroblast growth factor and dexamethasone in periodontal ligament cells http://www.medworm.com/index.php?rid=2581953&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01192.x Conclusion: The addition of Dex to culture reversed bFGF-mediated inhibition of mineralization. Use of combined bFGF and Dex to regulate PDL cell function may be a good therapeutic option to obtain periodontal regeneration. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581953 Tue, 07 Jul 2009 23:00:00 +0100 2581953 Effect of cyclic mechanical loading on osteoclast recruitment in periodontal tissue http://www.medworm.com/index.php?rid=2581952&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01193.x Conclusion: A new device was developed that allows various levels of cyclic mechanical loading to be exerted. By using this device in rats, early events of osteoclast recruitment in the periodontal tissues were observed with excessive loadings in a time-dependent manner, indicating the usefulness of this model. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581952 Tue, 07 Jul 2009 23:00:00 +0100 2581952 The association of psychosocial factors and smoking with periodontal health in a community population http://www.medworm.com/index.php?rid=2581951&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01194.x Conclusion: Poor mental health had a stronger association with periodontal disease among smokers than among nonsmokers, especially in accumulative attachment loss. Our findings suggest that mental health and smoking might have a synergistic effect on the risk of developing periodontal disease. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581951 Tue, 07 Jul 2009 23:00:00 +0100 2581951 Effects of mechanical stimulation by a powered toothbrush on the healing of periodontal tissue in a rat model of periodontal disease http://www.medworm.com/index.php?rid=2581950&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01195.x Conclusion: Mechanical stimulation accelerated the healing of gingival inflammation by reducing the infiltration of polymorphonuclear leukocytes and enhancing fibroblast proliferation and collagen synthesis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581950 Tue, 07 Jul 2009 23:00:00 +0100 2581950 Immunohistochemical localization of elastin, fibrillins and microfibril-associated glycoprotein-1 in the developing periodontal ligament of the rat molar http://www.medworm.com/index.php?rid=2581949&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01196.x Conclusion: Elastin expressed in the periodontal ligament assembled into elaunin fibers in the vicinity of blood vessels. Both fibrillin-2 and MAGP-1 are structural components not only of the elastin-associated microfibrils but also of elastin-free microfibrils, with possible roles in elastogenesis and in periodontal ligament homeostasis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581949 Tue, 07 Jul 2009 23:00:00 +0100 2581949 Host β-globin gene fragments in crevicular fluid as a biomarker in periodontal health and disease http://www.medworm.com/index.php?rid=2581948&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01197.x Conclusion: This study shows the different DNA profiles of cell-free gingival crevicular fluid in periodontal health and disease. It suggests that the quantity and quality of host DNA are dependent on the disease conditions. Therefore, the [beta]-globin gene fragments in cell-free gingival crevicular fluid may be a potential biomarker of periodontal disease progression. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581948 Tue, 07 Jul 2009 23:00:00 +0100 2581948 Green tea catechin inhibits lipopolysaccharide-induced bone resorption in vivo http://www.medworm.com/index.php?rid=2581947&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01198.x Conclusion: These results suggest that GTC suppresses LPS-induced bone resorption by inhibiting IL-1[beta] production or by directly inhibiting osteoclastogenesis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581947 Tue, 07 Jul 2009 23:00:00 +0100 2581947 Oral malodorous compound triggers mitochondrial-dependent apoptosis and causes genomic DNA damage in human gingival epithelial cells http://www.medworm.com/index.php?rid=2581946&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01199.x Conclusion: Hydrogen sulfide induces apoptosis in human gingival epithelial cells by activating the mitochondrial pathway. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581946 Tue, 07 Jul 2009 23:00:00 +0100 2581946 Hydrogen sulfide induces apoptosis in human periodontium cells http://www.medworm.com/index.php?rid=2581945&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01202.x Conclusion: These results showed that physiological concentrations of H2S can induce apoptosis of PDL cells and HGFs in periodontitis, suggesting that H2S may play an important role in periodontal tissue damage in periodontal diseases. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581945 Tue, 07 Jul 2009 23:00:00 +0100 2581945 Shosaikoto increases calprotectin expression in human oral epithelial cells http://www.medworm.com/index.php?rid=2581944&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01203.x Conclusion: These results suggest that SST increases the expression of calprotectin and S100A7 in oral epithelial cells. In response to SST, up-regulation of calprotectin may be partially induced via IL-1[alpha]. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581944 Tue, 07 Jul 2009 23:00:00 +0100 2581944 A multiplex immunoassay demonstrates reductions in gingival crevicular fluid cytokines following initial periodontal therapy http://www.medworm.com/index.php?rid=2581943&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01204.x Conclusion: This is the first study, to our knowledge, to evaluate such an extensive panel of gingival crevicular fluid mediators within the same sample prior to and following initial therapy. The results confirm that periodontal therapy effectively reduces pro-inflammatory cytokines and chemokines, including less well-described mediators that may be important in initiation and progression of periodontitis. The multiplex assay will prove useful for future gingival crevicular fluid studies. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581943 Tue, 07 Jul 2009 23:00:00 +0100 2581943 Epidermal growth factor released from platelet-rich plasma promotes endothelial cell proliferation in vitro http://www.medworm.com/index.php?rid=2581942&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01205.x Conclusion: This study showed that PRP supernatants are highly mitogenic for endothelial cells and provided evidence that this effect may be due, at least in part, to the presence of EGF. In vivo experiments are needed to confirm the roles of specific growth factors released from PRP in the healing of oral surgical and/or periodontal wounds. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581942 Tue, 07 Jul 2009 23:00:00 +0100 2581942 Preconditioning with Porphyromonas gingivalis lipopolysaccharide may confer cardioprotection and improve recovery of the electrically induced intracellular calcium transient during ischemia and reperfusion http://www.medworm.com/index.php?rid=2581941&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01206.x Conclusion: At a dosage of 0.5 mg/kg, P. gingivalis LPS confers cardioprotection against ischemia[ndash]reperfusion-induced injury and improved intracellular E[Ca2+]i transient recovery, hence improving myocyte contractile recovery. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581941 Tue, 07 Jul 2009 23:00:00 +0100 2581941 A novel murine model for chronic inflammatory alveolar bone loss http://www.medworm.com/index.php?rid=2581940&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01207.x Conclusion: These data show that oral administration of TNBS or DSS provokes alveolar bone loss in concert with the autochthonous oral microbiota. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581940 Tue, 07 Jul 2009 23:00:00 +0100 2581940 Effect of matrix metalloproteinase-1 promoter genotype on interleukin-1beta-induced matrix metalloproteinase-1 production in human periodontal ligament cells http://www.medworm.com/index.php?rid=2581939&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01208.x Conclusion: The results of the present study suggest that the single nucleotide polymorphism at nucleotide [minus]1607 of the human MMP-1 promoter might influence the interleukin-1beta-induced expression of MMP-1 in periodontal ligament cells. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581939 Tue, 07 Jul 2009 23:00:00 +0100 2581939 Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease http://www.medworm.com/index.php?rid=2581938&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01209.x Conclusion: Although periodontal infection does affect the concentration of hs-CRP and IL-6 in serum, a subgroup of patients exist who are highly susceptible to an increased risk of CHD associated with periodontitis, suggesting that there may be subjects who have an elevated risk of CHD independent of susceptibility to periodontal tissue destruction per se. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581938 Tue, 07 Jul 2009 23:00:00 +0100 2581938 A quinol peroxidase inhibitor prevents secretion of a leukotoxin from Aggregatibacter actinomycetemcomitans http://www.medworm.com/index.php?rid=2581937&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01211.x Conclusion: Quinol peroxidase inhibitors are promising candidates as alternative drugs for the treatment and prevention of the onset of localized aggressive periodontitis. Using ascofuranone as a seed compound, further study of QPO inhibitors could provide novel chemotherapeutic strategies for controlling localized aggressive periodontitis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2581937 Tue, 07 Jul 2009 23:00:00 +0100 2581937 Cyclosporine A enhances apoptosis in gingival keratinocytes of rats and in OECM1 cells via the mitochondrial pathway http://www.medworm.com/index.php?rid=2574173&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01189.x Conclusion: Based on the above findings, we suggest that cyclosporine A might enhance the apoptosis of gingival keratinocytes, mainly via the mitochondrial pathway. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2574173 Mon, 06 Jul 2009 23:00:00 +0100 2574173 Defining a visual marker of osteoprogenitor cells within the periodontium http://www.medworm.com/index.php?rid=2475878&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2009.01201.x Conclusion: Our data indicate that the [alpha]SMA promoter can be used to identify a population of osteoprogenitor cells residing within the dental follicle and periodontal ligament that can differentiate into mature osteoblasts. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2475878 Mon, 15 Jun 2009 04:00:00 +0100 2475878 Runt-related gene 2 is involved in the inhibition of matrix metalloproteinase-13 expression by roxithromycin in human gingival epithelial cell cultures. http://www.medworm.com/index.php?rid=2471963&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19453496%26dopt%3DAbstract CONCLUSION: These results indicate that RXM suppresses MMP-13 via the downregulation of Runx2 in human gingival epithelial cell cultures. PMID: 19453496 [PubMed - in process] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471963 Mon, 01 Jun 2009 04:00:00 +0100 2471963 Nicotinic acetylcholine receptor activation mediates nicotine-induced enhancement of experimental periodontitis. http://www.medworm.com/index.php?rid=2471961&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19453497%26dopt%3DAbstract CONCLUSION: The results indicate that nicotine enhances the susceptibility to periodontitis via nicotinic acetylcholine receptors, which may act by suppressing protective immune responses through the cholinergic anti-inflammatory pathway. PMID: 19453497 [PubMed - in process] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471961 Mon, 01 Jun 2009 04:00:00 +0100 2471961 Putative signaling action of amelogenin utilizes the Wnt/beta-catenin pathway. http://www.medworm.com/index.php?rid=2471774&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19462488%26dopt%3DAbstract CONCLUSION: Using the TOPGAL transgenic mouse we showed that amelogenin expression in vivo is localized mainly around the root, the periodontal ligament and the alveolar bone. PMID: 19462488 [PubMed - in process] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471774 Mon, 01 Jun 2009 04:00:00 +0100 2471774 The effect of Porphyromonas gingivalis infection on cytokine levels in type 2 diabetic mice. http://www.medworm.com/index.php?rid=2471773&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19462491%26dopt%3DAbstract CONCLUSION: These observations suggest that tumor necrosis factor-alpha, interleukin-6 and adiponectin are an integral part of the link between diabetes mellitus and Porphyromonas gingivalis infection. PMID: 19462491 [PubMed - in process] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471773 Mon, 01 Jun 2009 04:00:00 +0100 2471773 The use of live-animal micro-computed tomography to determine the effect of a novel phospholipase A2 inhibitor on alveolar bone loss in an in vivo mouse model of periodontitis. http://www.medworm.com/index.php?rid=2471772&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19462493%26dopt%3DAbstract CONCLUSION: Live-animal micro-computed tomography is a robust, reproducible technique that clearly demonstrates significant time-dependent changes in alveolar bone volume in a small-animal model of periodontitis. PMID: 19462493 [PubMed - in process] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471772 Mon, 01 Jun 2009 04:00:00 +0100 2471772 Parathyroid hormone administration may modulate periodontal tissue levels of interleukin-6, matrix metalloproteinase-2 and matrix metalloproteinase-9 in experimental periodontitis. http://www.medworm.com/index.php?rid=2471957&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19453852%26dopt%3DAbstract Conclusion: These data suggest that intermittent administration of parathyroid hormone can down-regulate the expression of biomarkers responsible for connective tissue breakdown and bone resorption, and potentially affect alveolar bone resorption activity. PMID: 19453852 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471957 Mon, 18 May 2009 04:00:00 +0100 2471957 Expression of metalloproteinases and their tissue inhibitors in gingiva affected by hereditary gingival fibromatosis: analysis of three cases within a family. http://www.medworm.com/index.php?rid=2471955&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19453853%26dopt%3DAbstract Conclusion: The mRNA expression of MMP-1 and -2 and TIMP-1 and -2 does not explain the gingival overgrowth presented in these cases. In addition, it is suggested that the gene expression of those molecules in the course of HGF is regulated at the translational or post-translational level. PMID: 19453853 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471955 Mon, 18 May 2009 04:00:00 +0100 2471955 Cigarette smoke condensate affects the collagen-degrading ability of human gingival fibroblasts. http://www.medworm.com/index.php?rid=2471920&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19453854%26dopt%3DAbstract Conclusion: Cigarette smoke condensate affects human gingival fibroblast proliferation and is toxic at total particulate matter cigarette smoke condensate concentrations of >/= 400 mug/mL. Cigarette smoke condensate can increase the collagen-degrading ability of human gingival fibroblasts by altering the production and localization of MMPs and TIMPs. PMID: 19453854 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471920 Mon, 18 May 2009 04:00:00 +0100 2471920 B-1a cells and plasma cells in periodontitis lesions. http://www.medworm.com/index.php?rid=2471911&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19453855%26dopt%3DAbstract Conclusion: It is suggested that B-1a cells constitute a significant part of the host response in periodontitis lesions and that plasma cells may develop from both B-2 and B-1a cells. PMID: 19453855 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471911 Mon, 18 May 2009 04:00:00 +0100 2471911 Cervical sympathectomy causes alveolar bone loss in an experimental rat model. http://www.medworm.com/index.php?rid=2471881&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19453856%26dopt%3DAbstract Conclusion: Both superior cervical ganglionectomy and oral challenge with P. gingivalis induced alveolar bone loss. These results provide new information on the occurrence of alveolar bone loss, in that both oral challenge with P. gingivalis and superior cervical ganglionectomy are important accelerating factors for alveolar bone loss. Thus, we suggest that the sympathetic nervous system is linked with the prevention of alveolar bone loss. PMID: 19453856 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471881 Mon, 18 May 2009 04:00:00 +0100 2471881 Extracellular neutrophil traps in periodontitis. http://www.medworm.com/index.php?rid=2471875&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19453857%26dopt%3DAbstract Conclusion: Trapping the crevicular bacteria prevents their adhesion to and invasion of the gingiva. The combination of neutrophil extracellular traps and crevicular exudate outflow appears to be a 'novel' defense mechanism for the clearance of crevicular bacteria in chronic periodontitis. PMID: 19453857 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471875 Mon, 18 May 2009 04:00:00 +0100 2471875 Early osteogenic differential protein profile detected by proteomic analysis in human periodontal ligament cells. http://www.medworm.com/index.php?rid=2471828&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19453858%26dopt%3DAbstract Conclusion: Our results suggest that the proteins identified in this study may be associated with the unique function of periodontal ligament cells in maintaining periodontal tissue homeostasis, thus providing a comprehensive reference for understanding and investigating in greater detail the molecular mechanisms of periodontal ligament cells involved in periodontal regeneration. PMID: 19453858 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471828 Mon, 18 May 2009 04:00:00 +0100 2471828 Interleukin-2 -330 and 166 gene polymorphisms in relation to aggressive or chronic periodontitis and the presence of periodontopathic bacteria. http://www.medworm.com/index.php?rid=2471820&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19453859%26dopt%3DAbstract Conclusion: The interleukin-2 genotypes -330 TG and 166 TT, as well as the combination genotype interleukin-2 TT : TT, could be putative prognostic factors for chronic periodontitis. PMID: 19453859 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471820 Mon, 18 May 2009 04:00:00 +0100 2471820 Initial comparison of proteomic profiles of whole unstimulated saliva obtained from generalized aggressive periodontitis patients and healthy control subjects. http://www.medworm.com/index.php?rid=2471819&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19453860%26dopt%3DAbstract Conclusion: Comparison of the proteomic profile of whole unstimulated saliva of GAgP subjects with that of healthy control subjects revealed at least 11 differential proteins. The approach applied herein might be helpful to aid understanding of the etiology of GAgP. PMID: 19453860 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471819 Mon, 18 May 2009 04:00:00 +0100 2471819 Measurement of plaque-forming macrophages activated by lipopolysaccharide in a micro-channel chip. http://www.medworm.com/index.php?rid=2471818&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19453861%26dopt%3DAbstract Conclusion: These findings indicate that LPS-activated macrophages accumulate in micro-channel arrays, and suggest that macrophage plaque formation is a two-step procedure: (1) LPS-activated macrophages adhere physically to the silicon rubber layer on micro-pillars; and (2) consequently, the cells adhere to the activated macrophage layer. PMID: 19453861 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471818 Mon, 18 May 2009 04:00:00 +0100 2471818 Measurement of plaque-forming macrophages activated by lipopolysaccharide in a micro-channel chip http://www.medworm.com/index.php?rid=2488237&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01167.x Conclusion: These findings indicate that LPS-activated macrophages accumulate in micro-channel arrays, and suggest that macrophage plaque formation is a two-step procedure: (1) LPS-activated macrophages adhere physically to the silicon rubber layer on micro-pillars; and (2) consequently, the cells adhere to the activated macrophage layer. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488237 Sun, 17 May 2009 23:00:00 +0100 2488237 Initial comparison of proteomic profiles of whole unstimulated saliva obtained from generalized aggressive periodontitis patients and healthy control subjects http://www.medworm.com/index.php?rid=2488236&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01172.x Conclusion: Comparison of the proteomic profile of whole unstimulated saliva of GAgP subjects with that of healthy control subjects revealed at least 11 differential proteins. The approach applied herein might be helpful to aid understanding of the etiology of GAgP. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488236 Sun, 17 May 2009 23:00:00 +0100 2488236 Interleukin-2 −330 and 166 gene polymorphisms in relation to aggressive or chronic periodontitis and the presence of periodontopathic bacteria http://www.medworm.com/index.php?rid=2488235&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01173.x Conclusion: The interleukin-2 genotypes [minus]330 TG and 166 TT, as well as the combination genotype interleukin-2 TT : TT, could be putative prognostic factors for chronic periodontitis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488235 Sun, 17 May 2009 23:00:00 +0100 2488235 Early osteogenic differential protein profile detected by proteomic analysis in human periodontal ligament cells http://www.medworm.com/index.php?rid=2488234&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01174.x Conclusion: Our results suggest that the proteins identified in this study may be associated with the unique function of periodontal ligament cells in maintaining periodontal tissue homeostasis, thus providing a comprehensive reference for understanding and investigating in greater detail the molecular mechanisms of periodontal ligament cells involved in periodontal regeneration. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488234 Sun, 17 May 2009 23:00:00 +0100 2488234 Extracellular neutrophil traps in periodontitis http://www.medworm.com/index.php?rid=2488233&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01175.x Conclusion: Trapping the crevicular bacteria prevents their adhesion to and invasion of the gingiva. The combination of neutrophil extracellular traps and crevicular exudate outflow appears to be a 'novel' defense mechanism for the clearance of crevicular bacteria in chronic periodontitis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488233 Sun, 17 May 2009 23:00:00 +0100 2488233 Cervical sympathectomy causes alveolar bone loss in an experimental rat model http://www.medworm.com/index.php?rid=2488232&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01177.x Conclusion: Both superior cervical ganglionectomy and oral challenge with P. gingivalis induced alveolar bone loss. These results provide new information on the occurrence of alveolar bone loss, in that both oral challenge with P. gingivalis and superior cervical ganglionectomy are important accelerating factors for alveolar bone loss. Thus, we suggest that the sympathetic nervous system is linked with the prevention of alveolar bone loss. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488232 Sun, 17 May 2009 23:00:00 +0100 2488232 B-1a cells and plasma cells in periodontitis lesions http://www.medworm.com/index.php?rid=2488231&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01178.x Conclusion: It is suggested that B-1a cells constitute a significant part of the host response in periodontitis lesions and that plasma cells may develop from both B-2 and B-1a cells. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488231 Sun, 17 May 2009 23:00:00 +0100 2488231 Cigarette smoke condensate affects the collagen-degrading ability of human gingival fibroblasts http://www.medworm.com/index.php?rid=2488230&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01179.x Conclusion: Cigarette smoke condensate affects human gingival fibroblast proliferation and is toxic at total particulate matter cigarette smoke condensate concentrations of [ge] 400 [mu]g/mL. Cigarette smoke condensate can increase the collagen-degrading ability of human gingival fibroblasts by altering the production and localization of MMPs and TIMPs. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488230 Sun, 17 May 2009 23:00:00 +0100 2488230 Expression of metalloproteinases and their tissue inhibitors in gingiva affected by hereditary gingival fibromatosis: analysis of three cases within a family http://www.medworm.com/index.php?rid=2488229&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01180.x Conclusion: The mRNA expression of MMP-1 and -2 and TIMP-1 and -2 does not explain the gingival overgrowth presented in these cases. In addition, it is suggested that the gene expression of those molecules in the course of HGF is regulated at the translational or post-translational level. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488229 Sun, 17 May 2009 23:00:00 +0100 2488229 Parathyroid hormone administration may modulate periodontal tissue levels of interleukin-6, matrix metalloproteinase-2 and matrix metalloproteinase-9 in experimental periodontitis http://www.medworm.com/index.php?rid=2488228&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01186.x Conclusion: These data suggest that intermittent administration of parathyroid hormone can down-regulate the expression of biomarkers responsible for connective tissue breakdown and bone resorption, and potentially affect alveolar bone resorption activity. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488228 Sun, 17 May 2009 23:00:00 +0100 2488228 Defining a visual marker of osteoprogenitor cells within the periodontium. http://www.medworm.com/index.php?rid=2471959&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19453851%26dopt%3DAbstract Conclusion: Our data indicate that the alphaSMA promoter can be used to identify a population of osteoprogenitor cells residing within the dental follicle and periodontal ligament that can differentiate into mature osteoblasts. PMID: 19453851 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471959 Thu, 30 Apr 2009 04:00:00 +0100 2471959 Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes. http://www.medworm.com/index.php?rid=2471965&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19364390%26dopt%3DAbstract Conclusion: Our data highlight the role of oxidative stress in arecoline-mediated cell death, gene regulation and inflammatory processes in human keratinocytes. PMID: 19364390 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2471965 Wed, 01 Apr 2009 04:00:00 +0100 2471965 Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes http://www.medworm.com/index.php?rid=2488238&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01176.x Conclusion: Our data highlight the role of oxidative stress in arecoline-mediated cell death, gene regulation and inflammatory processes in human keratinocytes. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488238 Tue, 31 Mar 2009 23:00:00 +0100 2488238 Regulation of extracellular matrix genes by arecoline in primary gingival fibroblasts requires epithelial factors http://www.medworm.com/index.php?rid=2488239&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01185.x Conclusion: Taken together, our data highlight the importance of arecolineinduced epithelial changes in the pathogenesis of oral submucous fibrosis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488239 Sun, 29 Mar 2009 23:00:00 +0100 2488239 In vitro and in vivo cytokeratin patterns of expression in bioengineered human periodontal mucosa http://www.medworm.com/index.php?rid=2488240&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01159.x Conclusion: The results indicate that this model of human oral mucosa, constructed using fibrin[ndash]agarose scaffolds, shows similarities to native oral mucosa controls and imply that bioengineered oral mucosa substitutes could eventually be used clinically. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488240 Fri, 13 Mar 2009 00:00:00 +0100 2488240 The apical region of developing tooth root constitutes a complex and maintains the ability to generate root and periodontium-like tissues. http://www.medworm.com/index.php?rid=2247818&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19261077%26dopt%3DAbstract Conclusion: The sustainable development ability of developing apical complex qualifies it as the growth center of tooth root and as a promising candidate source of cells for tooth root and periodontal regeneration. PMID: 19261077 [PubMed - in process] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2247818 Sun, 08 Mar 2009 10:05:27 +0100 2247818 Cyclosporine A inhibits the expression of membrane type-I matrix metalloproteinase in gingiva. http://www.medworm.com/index.php?rid=2185640&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19210333%26dopt%3DAbstract Conclusion: Cyclosporine A inhibits the expression of membrane type-I MMP in gingiva and it may further reduce the activation of MMP-2. PMID: 19210333 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2185640 Fri, 06 Feb 2009 05:00:00 +0100 2185640 The effect of platelet-rich plasma on osteoblast and periodontal ligament cell migration, proliferation and differentiation. http://www.medworm.com/index.php?rid=2185639&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19210334%26dopt%3DAbstract Conclusion: Platelet-rich plasma can exert a positive effect on osteoblast and periodontal ligament cell function, but this effect is concentration specific with maximal concentrations not necessarily resulting in optimal outcomes. Platelet-poor plasma also appears to have the ability to promote wound healing-associated cell function. PMID: 19210334 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2185639 Fri, 06 Feb 2009 05:00:00 +0100 2185639 Periodontitis-induced lipid peroxidation in rat descending aorta is involved in the initiation of atherosclerosis. http://www.medworm.com/index.php?rid=2185638&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19210335%26dopt%3DAbstract Conclusion: In a ligature-induced periodontitis rat model, increased lipid peroxidation was found in serum and aorta as well as in periodontal tissue. Atherosclerosis-related gene expression and histological changes were also stimulated. Periodontitis-induced lipid peroxidation in the aorta may be involved in the early stage of atherosclerosis. PMID: 19210335 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2185638 Fri, 06 Feb 2009 05:00:00 +0100 2185638 Salivary cytokine levels in subjects with chronic periodontitis and in periodontally healthy individuals: a cross-sectional study. http://www.medworm.com/index.php?rid=2185637&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19210336%26dopt%3DAbstract Conclusion: Mean salivary levels of granulocyte-macrophage colony-stimulating factor, interleukin-1beta, interleukin-2, interleukin-4, interleukin-5, interleukin-6, interleukin-8, interleukin-10, interferon-gamma and tumor necrosis factor-alpha could not discriminate between periodontal health and disease. PMID: 19210336 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2185637 Fri, 06 Feb 2009 05:00:00 +0100 2185637 Cyclooxygenase-2-derived prostaglandin E(2) is involved in vascular endothelial growth factor production in interleukin-1alpha-stimulated human periodontal ligament cells. http://www.medworm.com/index.php?rid=2185636&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19210337%26dopt%3DAbstract Conclusion: We suggest that interleukin-1alpha induced vascular endothelial growth factor production via cyclooxygenase-2-derived prostaglandin E(2) in human periodontal ligament cells. The interleukin-1alpha/prostaglandin E(2) pathway might regulate vascular endothelial growth factor production in periodontal lesions. PMID: 19210337 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2185636 Fri, 06 Feb 2009 05:00:00 +0100 2185636 Interleukin-10 (-592 C/A) and interleukin-12B (+16974 A/C) gene polymorphisms and the interleukin-10 ATA haplotype are associated with periodontitis in a Taiwanese population. http://www.medworm.com/index.php?rid=2185635&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19210338%26dopt%3DAbstract Conclusion: The interleukin-10 gene polymorphism at position -592C>A may be associated with a lower risk for development of chronic periodontitis. The interleukin-10 haplotype ATA is associated with generalized aggressive periodontitis. On the other hand, interleukin-12B genetic variants at position +16974 are associated with susceptibility to chronic periodontitis. PMID: 19210338 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2185635 Fri, 06 Feb 2009 05:00:00 +0100 2185635 Cigarette smoke condensate stimulates urokinase production through the generation of reactive oxygen species and activation of the mitogen activated protein kinase pathways in human gingival fibroblasts. http://www.medworm.com/index.php?rid=2185634&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19210339%26dopt%3DAbstract Conclusion: Cigarette smoke condensate stimulates urokinase production and plasmin activation in gingival fibroblasts. Moreover, cigarette smoke condensate-stimulated urokinase production depends on both the activation of ERK/JNK pathways and on the generation of intracellular reactive oxygen species. These results show that cigarette smoke may alter connective tissue remodeling by inducing production of the urokinase-type plasminogen activator through specific signaling pathways. PMID: 19210339 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2185634 Fri, 06 Feb 2009 05:00:00 +0100 2185634 Neutrophils in chronic and aggressive periodontitis in interaction with Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. http://www.medworm.com/index.php?rid=2185633&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19210340%26dopt%3DAbstract Conclusion: High serum IgG levels against P. gingivalis and A. actinomycetemcomitans promote phagocytosis in periodontitis. The extracellular release of reactive oxygen species and neutrophil elastase by polymorphonuclear neutrophils may also contribute to damage of the surrounding periodontal tissues. PMID: 19210340 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2185633 Fri, 06 Feb 2009 05:00:00 +0100 2185633 Effect of dietary omega-3 polyunsaturated fatty acids on experimental periodontitis in the mouse. http://www.medworm.com/index.php?rid=2185632&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19210341%26dopt%3DAbstract Conclusion: Alveolar bone loss was inversely related to n-3 polyunsaturated fatty acid tissue levels. In conclusion, fish oil dietary supplementation may have potential benefits as a host modulatory agent in the prevention and/or adjunctive management of periodontitis. PMID: 19210341 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2185632 Fri, 06 Feb 2009 05:00:00 +0100 2185632 Family-based association analysis of S100A8 genetic polymorphisms with aggressive periodontitis. http://www.medworm.com/index.php?rid=2185631&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19210342%26dopt%3DAbstract Conclusions: This family-based association study supports the previous findings that SNP rs3795391 (A > G) of the S100A8 gene might contribute to AgP susceptibility. This is, to our knowledge, the first investigation about AgP using FBAT in genetic analysis. PMID: 19210342 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2185631 Fri, 06 Feb 2009 05:00:00 +0100 2185631 Effect of transforming growth factor-beta1 on expression of the connective tissue growth factor (CCN2/CTGF) gene in normal human gingival fibroblasts and periodontal ligament cells. http://www.medworm.com/index.php?rid=2185630&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19210343%26dopt%3DAbstract Conclusion: The expression of CCN2/CTGF mRNA and protein was induced by transforming growth factor-beta1 in human gingival fibroblasts and periodontal ligament cells. These results suggest that CCN2/CTGF plays an important role in wound healing and in the regeneration of periodontal tissue. PMID: 19210343 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2185630 Fri, 06 Feb 2009 05:00:00 +0100 2185630 Role of systemic and local administration of selective inhibitors of cyclo-oxygenase 1 and 2 in an experimental model of periodontal disease in rats. http://www.medworm.com/index.php?rid=2185629&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19210344%26dopt%3DAbstract Conclusion: Our results provide evidence for participation of COX-1 and COX-2 in early stages of periodontal disease in rats. Furthermore, local administration of COX inhibitors reduced the signs of periodontal disease to the same extent as systemic treatment. Therapeutic approaches incorporating locally delivered anti-inflammatory drugs could be of benefit for patients suffering from periodontal disease. PMID: 19210344 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2185629 Fri, 06 Feb 2009 05:00:00 +0100 2185629 Relationship between periodontal parameters and Behçet's disease and evaluation of different treatments for oral recurrent aphthous stomatitis. http://www.medworm.com/index.php?rid=2044191&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19076988%26dopt%3DAbstract Conclusion: Our results suggest that periodontal status is worse in BD patients and is associated with disease severity; also, the Nd:YAG laser has better patient acceptance, shorter treatment time and lower rates of pain and post-treatment adverse events among BD patients with oral recurrent aphthous stomatitis. PMID: 19076988 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2044191 Thu, 11 Dec 2008 05:00:00 +0100 2044191 Tumor necrosis factor-alpha -308G/A single nucleotide polymorphism and red-complex periodontopathogens are independently associated with increased levels of tumor necrosis factor-alpha in diseased periodontal tissues. http://www.medworm.com/index.php?rid=2044190&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19076989%26dopt%3DAbstract Conclusion: Our results demonstrate that the TNFA-308 A allele and red-complex periodontopathogens are independently associated with increased levels of tumor necrosis factor-alpha in diseased tissues of nonsmoking chronic periodontitis patients and consequently are potentially involved in determining the disease outcome. PMID: 19076989 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2044190 Thu, 11 Dec 2008 05:00:00 +0100 2044190 Simvastatin therapy in cyclosporine A-induced alveolar bone loss in rats. http://www.medworm.com/index.php?rid=2044189&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19076990%26dopt%3DAbstract Conclusion: This study shows that simvastatin therapy leads to a reversal of the cyclosporine A-induced bone loss, which may be mediated by downregulation of interleukin-1beta and prostaglandin E(2) production. PMID: 19076990 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2044189 Thu, 11 Dec 2008 05:00:00 +0100 2044189 Participation of the secreted dipeptidyl and tripeptidyl aminopeptidases in asaccharolytic growth of Porphyromonas gingivalis. http://www.medworm.com/index.php?rid=2044188&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19076991%26dopt%3DAbstract Conclusion: DPPIV, DPP-7 and PTP-A contribute to the normal growth of P. gingivalis by cleaving substrate peptides into short-chain polypeptides that are efficient energy sources for P. gingivalis. PMID: 19076991 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2044188 Thu, 11 Dec 2008 05:00:00 +0100 2044188 Relationship between periodontal parameters and Behçet's disease and evaluation of different treatments for oral recurrent aphthous stomatitis http://www.medworm.com/index.php?rid=2488243&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01183.x Conclusion: Our results suggest that periodontal status is worse in BD patients and is associated with disease severity; also, the Nd:YAG laser has better patient acceptance, shorter treatment time and lower rates of pain and post-treatment adverse events among BD patients with oral recurrent aphthous stomatitis. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488243 Thu, 11 Dec 2008 00:00:00 +0100 2488243 Tumor necrosis factor-alpha −308G/A single nucleotide polymorphism and red-complex periodontopathogens are independently associated with increased levels of tumor necrosis factor-α in diseased periodontal tissues http://www.medworm.com/index.php?rid=2488242&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01166.x Conclusion: Our results demonstrate that the TNFA[minus]308 A allele and red-complex periodontopathogens are independently associated with increased levels of tumor necrosis factor-alpha in diseased tissues of nonsmoking chronic periodontitis patients and consequently are potentially involved in determining the disease outcome. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488242 Thu, 11 Dec 2008 00:00:00 +0100 2488242 Variability in the response of human dendritic cells stimulated with Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans. http://www.medworm.com/index.php?rid=1987263&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19031495%26dopt%3DAbstract CONCLUSION: These results demonstrate that A. actinomycetemcomitans is a more potent immunogen than P. gingivalis because, at least in vitro, it induces stronger differentiation and activation of dendritic cells. In addition, our data also show that for a given strain, the bacterial load determines the pattern of cytokines that are expressed. PMID: 19031495 [PubMed - in process] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1987263 Thu, 27 Nov 2008 04:20:13 +0100 1987263 Nicotine suppresses bone sialoprotein gene expression http://www.medworm.com/index.php?rid=2488244&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01171.x Conclusion: This study indicates that nicotine suppresses BSP transcription mediated through CRE, FRE and HOX elements in the proximal promoter of the rat BSP gene. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488244 Sun, 23 Nov 2008 00:00:00 +0100 2488244 Corrigendum. http://www.medworm.com/index.php?rid=1963129&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19007386%26dopt%3DAbstract Authors: PMID: 19007386 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1963129 Mon, 17 Nov 2008 04:00:37 +0100 1963129 Immunolocalization of laminin and integrin in regenerating junctional epithelium of mice after gingivectomy. http://www.medworm.com/index.php?rid=1925932&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973515%26dopt%3DAbstract Conclusion: These results suggest that secretion of laminin 5 in the connective tissue may induce epithelial cell migration, and that binding of laminin 5 to integrin alpha(6)beta(4) and integrin alpha(3)beta(1) in the IBL may provoke cell adhesion and migration of cells facing the tooth on the enamel surface of the regenerating junctional epithelium. PMID: 18973515 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925932 Wed, 29 Oct 2008 04:00:00 +0100 1925932 Multipotency of clonal cells derived from swine periodontal ligament and differential regulation by fibroblast growth factor and bone morphogenetic protein. http://www.medworm.com/index.php?rid=1925931&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973516%26dopt%3DAbstract Conclusion: Periodontal ligament fibroblasts have the potential to differentiate not only into osteoblastic but also into vascular cell lineages. The destiny of the cells was reciprocally regulated by BMP-2 and FGF-2. PMID: 18973516 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925931 Wed, 29 Oct 2008 04:00:00 +0100 1925931 Effects of smoking on the ex vivo cytokine production in periodontitis. http://www.medworm.com/index.php?rid=1925930&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973517%26dopt%3DAbstract Conclusion: A more pronounced Th2 response in smoking periodontitis patients may be related to increased severity of the disease. PMID: 18973517 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925930 Wed, 29 Oct 2008 04:00:00 +0100 1925930 Characteristic changes of periodontal ligament-derived cells during passage. http://www.medworm.com/index.php?rid=1925899&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973549%26dopt%3DAbstract Conclusion: Cultured periodontal ligament-derived cells were a morphologically homogeneous population, although expression of STRO-1 was limited in primary culture. Cultured cells showed de-differentiation during passage for both osteogenesis- and tendo/ligamentogenesis-related genes. PMID: 18973549 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925899 Wed, 29 Oct 2008 04:00:00 +0100 1925899 Anticalculus effect of a triclosan mouthwash containing phytate: a double-blind, randomized, three-period crossover trial. http://www.medworm.com/index.php?rid=1925929&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973518%26dopt%3DAbstract Conclusion: The high efficacy of phytate in reducing dental calculus formation suggests that this substance may be an effective treatment for preventing the development of calculus deposits. PMID: 18973518 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925929 Wed, 22 Oct 2008 04:00:00 +0100 1925929 Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in blood as markers for early atherosclerosis in subjects with chronic periodontitis. http://www.medworm.com/index.php?rid=1925928&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973519%26dopt%3DAbstract Conclusion: Matrix metalloproteinase-9, TIMP-1 and MMP-9/TIMP-1 in blood from subjects with periodontal disease could be useful laboratory markers for increased carotid artery intima-media thickness. PMID: 18973519 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925928 Wed, 22 Oct 2008 04:00:00 +0100 1925928 Treponema denticola peptidoglycan induces the production of inflammatory mediators and matrix metalloproteinase 9 in macrophage-like cells. http://www.medworm.com/index.php?rid=1925927&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973520%26dopt%3DAbstract Conclusion: T. denticola peptidoglycan activates intracellular signaling pathways, leading to an increased production of inflammatory mediators by macrophage-like cells. PMID: 18973520 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925927 Wed, 22 Oct 2008 04:00:00 +0100 1925927 Stretching stimulates fibulin-5 expression and controls microfibril bundles in human periodontal ligament cells. http://www.medworm.com/index.php?rid=1925926&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973521%26dopt%3DAbstract Conclusion: These results suggest that fibulin-5 up-regulated in response to tension strain may control the formation of microfibril bundles in periodontal ligament. PMID: 18973521 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925926 Wed, 22 Oct 2008 04:00:00 +0100 1925926 The influence of thyroid hormones on periodontitis-related bone loss and tooth-supporting alveolar bone: a histological study in rats. http://www.medworm.com/index.php?rid=1925925&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973522%26dopt%3DAbstract Conclusion: It may be concluded that decreased serum levels of thyroid hormones may enhance periodontitis-related bone loss, as a function of an increased number of resorbing cells, whereas the tooth-supporting alveolar bone seems to be less sensitive to alterations in hormone levels. PMID: 18973522 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925925 Wed, 22 Oct 2008 04:00:00 +0100 1925925 Effect of exogenous nitric oxide on murine immune response induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide. http://www.medworm.com/index.php?rid=1925898&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973550%26dopt%3DAbstract Conclusion: The present study suggests that exogenous NO may suppress a protective T helper 1-like murine immune response to A. actinomycetemcomitans LPS by an endogenous NO-independent but a cyclic GMP-dependent mechanism. PMID: 18973550 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925898 Wed, 22 Oct 2008 04:00:00 +0100 1925898 Stretching stimulates fibulin-5 expression and controls microfibril bundles in human periodontal ligament cells http://www.medworm.com/index.php?rid=2488245&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01170.x Conclusion: These results suggest that fibulin-5 up-regulated in response to tension strain may control the formation of microfibril bundles in periodontal ligament. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488245 Tue, 21 Oct 2008 23:00:00 +0100 2488245 Anticalculus effect of a triclosan mouthwash containing phytate: a double-blind, randomized, three-period crossover trial http://www.medworm.com/index.php?rid=2488241&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1600-0765.2008.01168.x Conclusion: The high efficacy of phytate in reducing dental calculus formation suggests that this substance may be an effective treatment for preventing the development of calculus deposits. (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=2488241 Tue, 21 Oct 2008 23:00:00 +0100 2488241 Matrix metalloproteinase inhibitors reduce collagen gel contraction and alpha-smooth muscle actin expression by periodontal ligament cells. http://www.medworm.com/index.php?rid=1925924&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973523%26dopt%3DAbstract Conclusion: Synthetic MMP inhibitors strongly reduced gel contraction by periodontal ligament cells. This was primarily caused by an inhibitory effect on MMP activity, which reduces matrix remodeling. In addition, alpha-smooth muscle actin expression was reduced by CMT-3 and doxycycline, which limits the contractile activity of the fibroblasts. PMID: 18973523 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925924 Tue, 07 Oct 2008 04:00:00 +0100 1925924 Induction of cementogenesis and periodontal ligament regeneration by recombinant human transforming growth factor-beta3 in Matrigel with rectus abdominis responding cells. http://www.medworm.com/index.php?rid=1925923&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973524%26dopt%3DAbstract Conclusion: Matrigel((R)) matrix is an optimal delivery system for the osteogenic proteins of the transforming growth factor-beta superfamily, including the mammalian transforming growth factor-beta3 isoform. The addition of minced fragments of rectus abdominis muscle provides responding stem cells for further tissue induction and morphogenesis by the transforming growth factor-beta3 protein. PMID: 18973524 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925923 Tue, 07 Oct 2008 04:00:00 +0100 1925923 Autoantibodies to beta(1)-adrenoceptors in human chronic periodontitis induce overexpression of fibroblast CD40 and trigger prostaglandin E(2) generation. http://www.medworm.com/index.php?rid=1925922&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973525%26dopt%3DAbstract Conclusion: This article supports the participation of humoral immune alterations in chronic periodontal disease resulting in postsynaptic functional deregulation. Overproduction of proinflammatory mediators (PGE(2) and CD40 expression) is induced as a consequence of antibody-beta(1)-AR interaction. The PGE(2)-CD40-IgG axis may play a part in the pathophysiological mechanisms underlying the inflammatory process in chronic periodontal disease. PMID: 18973525 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925922 Tue, 07 Oct 2008 04:00:00 +0100 1925922 Expression and bioactivities of endothelin-1 in gingiva during cyclosporine A treatment. http://www.medworm.com/index.php?rid=1925921&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973526%26dopt%3DAbstract Conclusion: Based on the present findings, we suggest that: (1) CsA upregulates the gingival expression of ET-1 and its receptors; and (2) ET(A) and ET(B) have different bioactivities, ET(A) being involved in cell proliferation and ET(B) being associated with iNOS expression. PMID: 18973526 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925921 Tue, 07 Oct 2008 04:00:00 +0100 1925921 Gender differences in systemic inflammation and atheroma formation following Porphyromonas gingivalis infection in heterozygous apolipoprotein E-deficient mice. http://www.medworm.com/index.php?rid=1925920&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973527%26dopt%3DAbstract Conclusion: In these young mice, P. gingivalis infection induced sex-specific changes in serum lipids but no gender differences in acute phase proteins and atheroma lesion score. PMID: 18973527 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925920 Tue, 07 Oct 2008 04:00:00 +0100 1925920 Porphyromonas gingivalis fimbriae induce unique dendritic cell subsets via Toll-like receptor 2. http://www.medworm.com/index.php?rid=1925919&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973528%26dopt%3DAbstract Conclusion: These results indicate that different TLR usage affects mature DC phenotype and function and is thus crucial to the regulation of immunity to the pathogen. PMID: 18973528 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925919 Tue, 07 Oct 2008 04:00:00 +0100 1925919 Surface components of Porphyromonas gingivalis. http://www.medworm.com/index.php?rid=1925918&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973529%26dopt%3DAbstract Conclusion: Surface components of P. gingivalis somehow have contact with host tissues and cells because of the outermost cell elements. Therefore, such bacterial components are potentially important in the occurrence of periodontal diseases. PMID: 18973529 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925918 Tue, 07 Oct 2008 04:00:00 +0100 1925918 Gingival crevicular fluid and plasma levels of neuropeptide Substance-P in periodontal health, disease and after nonsurgical therapy. http://www.medworm.com/index.php?rid=1925917&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973530%26dopt%3DAbstract Conclusion: Substance-P levels were highest in the gingival crevicular fluid from sites with periodontal destruction; however, periodontal treatment resulted in the reduction of Substance-P levels. Gingival crevicular fluid and plasma Substance-P levels showed a positive correlation in all of the groups. PMID: 18973530 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925917 Tue, 07 Oct 2008 04:00:00 +0100 1925917 Relationship between the gingival sulcus depth and interleukin-1 isoform concentrations within the adjacent gingival tissue. http://www.medworm.com/index.php?rid=1925916&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973531%26dopt%3DAbstract Conclusion: Our data indicated a progressive increase in gingival concentrations of interleukin-1 isoforms with increased adjacent sulcular depth. However, within 'diseased' tissues, the proportional concentrations of interleukin-1alpha and -beta to interleukin-1 receptor antagonist were lowest within diseased-severe tissues. PMID: 18973531 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925916 Tue, 07 Oct 2008 04:00:00 +0100 1925916 Identifying early osteoclastic resorptive lesions in feline teeth: a model for understanding the origin of multiple idiopathic root resorption. http://www.medworm.com/index.php?rid=1925915&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973532%26dopt%3DAbstract Conclusion: Resorption is prevalent without evidence of clinical disease, and occured at younger ages than previously reported. It can initiate anywhere on the root surface, but lack of repair of lesions at the cemento-enamel junction indicates that mechanisms of replacement are absent or compromised in this region. Whereas resorption of the root may undergo repair, resorption at the cervix may progress to clinically evident lesions. PMID: 18973532 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925915 Tue, 07 Oct 2008 04:00:00 +0100 1925915 Periodontal disease in patients with familial Mediterranean fever: from inflammation to amyloidosis. http://www.medworm.com/index.php?rid=1925914&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973533%26dopt%3DAbstract Conclusion: Periodontal therapy seems to reduce the serum levels of acute-phase reactants in patients with familial Mediterranean fever. Therefore, treating periodontitis might help to alleviate the disease burden in patients with familial Mediterranean fever. PMID: 18973533 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925914 Tue, 07 Oct 2008 04:00:00 +0100 1925914 Areca nut extracts increased expression of inflammatory cytokines, tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells. http://www.medworm.com/index.php?rid=1925913&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973534%26dopt%3DAbstract Conclusion: The complex cytokine profile induced by areca nut extracts-treated peripheral blood mononuclear cells implied the possibility of enhanced local inflammation and altered immune functions by the areca chewing habit. The inhibitory effects of curcumin on cytokine expression suggested that oxidative stress might be involved in areca nut extracts-associated immune alteration. PMID: 18973534 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925913 Tue, 07 Oct 2008 04:00:00 +0100 1925913 Experimental periodontitis in mice selected for maximal or minimal inflammatory reactions: increased inflammatory immune responsiveness drives increased alveolar bone loss without enhancing the control of periodontal infection. http://www.medworm.com/index.php?rid=1925912&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973535%26dopt%3DAbstract Conclusion: Our results demonstrate that the intensity of the inflammatory immune reaction is associated with the severity of experimental periodontitis, but not with the control of A. actinomycetemcomitans periodontal infection, suggesting that the occurrence of hyperinflammatory genotypes may not be an evolutionary advantage in the complex host-pathogen interaction observed in periodontal diseases. PMID: 18973535 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925912 Tue, 07 Oct 2008 04:00:00 +0100 1925912 Effects of heparin-binding epidermal growth factor-like growth factor on cell repopulation and signal transduction in periodontal ligament cells after scratch wounding in vitro. http://www.medworm.com/index.php?rid=1925911&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973536%26dopt%3DAbstract Conclusion: These results indicate that heparin-binding epidermal growth factor-like growth factor may constitute a critical factor in the wound healing of human periodontal ligament cells by a mechanism that requires the activation of Erk1/2 via specific interaction with epidermal growth factor receptor 1. PMID: 18973536 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925911 Tue, 07 Oct 2008 04:00:00 +0100 1925911 In vivo determination of multiple indices of periodontal inflammation by optical spectroscopy. http://www.medworm.com/index.php?rid=1925910&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973538%26dopt%3DAbstract Conclusion: This study established that optical spectroscopy can simultaneously determine multiple inflammatory indices directly in the periodontal tissues in vivo. Visible, near-infrared spectroscopy has the potential to be developed into a simple, reagent-free, user-friendly, chairside, site-specific, diagnostic and prognostic test for periodontitis. PMID: 18973538 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925910 Tue, 07 Oct 2008 04:00:00 +0100 1925910 Factors affecting human supragingival biofilm composition. II. Tooth position. http://www.medworm.com/index.php?rid=1925909&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973539%26dopt%3DAbstract Conclusion: While plaque mass was associated with differences in proportions of many species in supragingival biofilms, tooth location also was strongly associated with species proportions in both univariate and multivariate analyses. PMID: 18973539 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925909 Tue, 07 Oct 2008 04:00:00 +0100 1925909 Factors affecting human supragingival biofilm composition. I. Plaque mass. http://www.medworm.com/index.php?rid=1925908&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973540%26dopt%3DAbstract Conclusion: The proportions of individual species and microbial complexes in supragingival biofilms are influenced by the total numbers of organisms in the biofilm. PMID: 18973540 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925908 Tue, 07 Oct 2008 04:00:00 +0100 1925908 Elevation of collagen type I in fibroblast-keratinocyte cocultures emphasizes the decisive role of fibroblasts in the manifestation of the phenotype of cyclosporin A-induced gingival overgrowth. http://www.medworm.com/index.php?rid=1925907&cid=s_28245_11_f&fid=28245&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18973541%26dopt%3DAbstract Conclusion: Our results indicate that collagen type I is a target of cyclosporin A and that gingival fibroblasts are decisive for the manifestation of the gingival overgrowth-phenotype. Furthermore, the results suggest that cocultures of gingival overgrowth-derived gingival fibroblasts and gingival keratinocytes permit analysis of cyclosporin A-induced effects under more in vivo-like conditions. PMID: 18973541 [PubMed - as supplied by publisher] (Source: Journal of Periodontal Research) Journal of Periodontal Research journals http://www.medworm.com/rss/comments.php?id=1925907 Tue, 07 Oct 2008 04:00:00 +0100 1925907