MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of Thrombosis and Haemostasis' source. Wed, 08 Feb 2012 17:42:06 +0100 http://www.medworm.com/index.php?rid=5668081&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04651.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5668081 Wed, 01 Feb 2012 05:00:00 +0100 5668081 http://www.medworm.com/index.php?rid=5660565&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04650.x Conclusions: Hypertension associated with hypercholesterolemia is accompanied by structural modifications and expression of pro‐inflammatory molecules by vessel wall, the alteration of vascular tone, enhanced release of MPs and reduced EPCs; the ratio between the latter two may be considered as a marker of vascular dysfunction. Irbesartan that exhibit a pharmacological control on the levels of MPs and EPCs has the potential to restore homeostasis of the arterial wall. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5660565 Wed, 01 Feb 2012 05:00:00 +0100 5660565 http://www.medworm.com/index.php?rid=5649195&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2010.04626.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649195 Wed, 01 Feb 2012 05:00:00 +0100 5649195 http://www.medworm.com/index.php?rid=5649194&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04587.x See also Shermock KM, Streiff MB, Pinto BL, Kraus P, Pronovost PJ. Novel analysis of clinically relevant diagnostic errors in point‐of‐care devices. J Thromb Haemost 2011; 9: 1769–75; and Holland L. Novel analysis of clinically relevant diagnostic errors in point‐of‐care devices: a rebuttal. This issue, pp 321–2. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649194 Wed, 01 Feb 2012 05:00:00 +0100 5649194 http://www.medworm.com/index.php?rid=5649193&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04578.x See also Zakai NA, McClure LA. Racial differences in venous thromboembolism. J Thromb Haemost 2011; 9: 1877–82. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649193 Wed, 01 Feb 2012 05:00:00 +0100 5649193 http://www.medworm.com/index.php?rid=5649192&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04574.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649192 Wed, 01 Feb 2012 05:00:00 +0100 5649192 http://www.medworm.com/index.php?rid=5649191&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04569.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649191 Wed, 01 Feb 2012 05:00:00 +0100 5649191 http://www.medworm.com/index.php?rid=5649190&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04582.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649190 Wed, 01 Feb 2012 05:00:00 +0100 5649190 http://www.medworm.com/index.php?rid=5649189&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04584.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649189 Wed, 01 Feb 2012 05:00:00 +0100 5649189 http://www.medworm.com/index.php?rid=5649188&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04567.x Conclusions: Platelet aggregation and phosphorylation of phospholipase Cγ2 induced by collagen were attenuated in ADAP−/− platelets. However, aggregation and signaling induced by collagen‐related peptide (CRP), a GPVI‐selective agonist, were largely unaffected. Platelet adhesion to CRP was also unaffected by ADAP deficiency. Adhesion to the α2β1‐selective ligand GFOGER and to a peptide (III‐04), which supports adhesion that is dependent on both GPVI and α2β1, was reduced in ADAP−/− platelets. An impedance‐based label‐free detection technique, which measures adhesion and spreading of platelets, indicated that, in the absence of ADAP, spreading on GFOGER was also reduced. This was confirmed with non‐fluorescent differential‐interference contrast microscopy, wh... Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649188 Wed, 01 Feb 2012 05:00:00 +0100 5649188 http://www.medworm.com/index.php?rid=5649187&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04568.x Conclusions: The accuracy of POCT coagulometers seems, in this respect, to be generally acceptable, and they can be used in a clinical setting. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649187 Wed, 01 Feb 2012 05:00:00 +0100 5649187 http://www.medworm.com/index.php?rid=5649186&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04600.x Conclusions: Simple signal processing of the APTT and the use of dynamic parameters represents a stronger predictive marker for hypercoagulation in patients with verified venous thrombosis than the standard APTT measurement. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649186 Wed, 01 Feb 2012 05:00:00 +0100 5649186 http://www.medworm.com/index.php?rid=5649185&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04599.x Conclusion: Adding an electronic reminder to the admission note improved prophylaxis rates and reduced VTE rates across services. The system is easily reproducible and applicable to other facilities. The improvement obtained was modest, so additional measures will probably be needed to optimize prophylaxis rates. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649185 Wed, 01 Feb 2012 05:00:00 +0100 5649185 http://www.medworm.com/index.php?rid=5649184&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04598.x Conclusions: Venowave devices are effective in preventing VTE in high‐risk neurosurgical patients. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649184 Wed, 01 Feb 2012 05:00:00 +0100 5649184 http://www.medworm.com/index.php?rid=5649183&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04573.x Conclusions: No increased risk of death in individuals with thrombophilia, not even in those with a history of thrombosis, was observed. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649183 Wed, 01 Feb 2012 05:00:00 +0100 5649183 http://www.medworm.com/index.php?rid=5649182&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04576.x This article focuses on recent insights into the regulation of the cAMP/cGMP signaling network and on new targets of PKA and PKG in platelets. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649182 Wed, 01 Feb 2012 05:00:00 +0100 5649182 http://www.medworm.com/index.php?rid=5649179&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04649.x Conclusions: Proportion of patients with mean INR near 2.5 is a site‐level “signature” of care and an implicit measure of targeted INR. This proportion varies by site and is strongly associated with site‐level TTR. Our study suggests that sites wishing to improve TTR, and thereby improve patient outcomes, should avoid the explicit or implicit pursuit of non‐standard INR targets. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649179 Wed, 01 Feb 2012 05:00:00 +0100 5649179 http://www.medworm.com/index.php?rid=5649180&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04648.x Conclusions: DVT patients with silent PE at baseline had an increased incidence of symptomatic PE events during the first 15 days of anticoagulant therapy. This effect disappeared after 3 months of anticoagulation. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5649180 Tue, 31 Jan 2012 05:00:00 +0100 5649180 http://www.medworm.com/index.php?rid=5639085&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04646.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5639085 Sat, 28 Jan 2012 05:00:00 +0100 5639085 http://www.medworm.com/index.php?rid=5639088&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04643.x Conclusions: These findings establish that Clock regulates Thpo and Mpl expression in vivo and demonstrate an important link between the body’s circadian timing mechanisms and megakaryopoiesis. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5639088 Fri, 27 Jan 2012 05:00:00 +0100 5639088 http://www.medworm.com/index.php?rid=5639087&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04644.x Conclusions: TGF‐β1 is pro‐angiogenic in vivo and induces ECFC angiogenic properties in vitro, suggesting that TGF‐β1 may play a role during vascular remodeling in fibrotic disease states via endothelial progenitor cells. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5639087 Fri, 27 Jan 2012 05:00:00 +0100 5639087 http://www.medworm.com/index.php?rid=5639086&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04645.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5639086 Fri, 27 Jan 2012 05:00:00 +0100 5639086 http://www.medworm.com/index.php?rid=5620871&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04641.x Conclusions: Platelet aggregation recovers within 4 days of stopping aspirin but clopidogrel must be stopped for 10 days to achieve a normal aggregatory response. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5620871 Mon, 23 Jan 2012 05:00:00 +0100 5620871 http://www.medworm.com/index.php?rid=5620870&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04642.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5620870 Mon, 23 Jan 2012 05:00:00 +0100 5620870 http://www.medworm.com/index.php?rid=5609983&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04638.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5609983 Thu, 19 Jan 2012 05:00:00 +0100 5609983 http://www.medworm.com/index.php?rid=5609987&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04634.x Conclusion: Eight SNPs that strongly determine VWF levels, are not associated with stroke risk, neither individually, nor combined in a genetic score. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5609987 Wed, 18 Jan 2012 05:00:00 +0100 5609987 http://www.medworm.com/index.php?rid=5609986&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04635.x Conclusions: This meta‐analysis failed to find a statistically significant difference in major bleeding between warfarin, target INR 2.0 to 3.5, and ASA, 50 to 650 mg daily. The trend towards increased bleeding with warfarin appears to be explained by an excess of intracranial bleeding in warfarin patients. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5609986 Wed, 18 Jan 2012 05:00:00 +0100 5609986 http://www.medworm.com/index.php?rid=5609985&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04636.x Conclusions: Among the subgroup of major bleeding patients with warfarin‐associated ICH, those not correcting to either INR of ≤1.3 or INR of ≤1.5 with the use of FFP have an increased rate of mortality at 30 days. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5609985 Wed, 18 Jan 2012 05:00:00 +0100 5609985 http://www.medworm.com/index.php?rid=5609984&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04637.x Conclusions: our findings suggest that D‐dimer may be a useful diagnostic tool in the management of patients with suspected CVT. Future prospective studies are warranted to confirm our preliminary findings. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5609984 Wed, 18 Jan 2012 05:00:00 +0100 5609984 http://www.medworm.com/index.php?rid=5609990&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04631.x Conclusions: Among patients suspected for PE and those ultimately diagnosed with PE, European patients had higher acuity, higher pretest probability and worse outcome than U.S. patients. This work underscores importance of disease prevalence for pre‐test probability scoring approaches and for significance interpretation of imaging tests. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5609990 Tue, 17 Jan 2012 05:00:00 +0100 5609990 http://www.medworm.com/index.php?rid=5609989&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04632.x Conclusions: DM2 patients with inadequate glycemic control (HbA1c>53mmol/mol) have higher baseline platelet activity and incomplete suppression of platelet activity with 30 mg of aspirin. However, 100 mg of aspirin leads to optimal inhibition irrespective of glycemic control, and 300 mg does not further improve platelet suppression. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5609989 Tue, 17 Jan 2012 05:00:00 +0100 5609989 http://www.medworm.com/index.php?rid=5609988&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04633.x Conclusions: Knowledge of the patient’s genotype therefore might assist physicians to adjust doses in the first month(s) of therapy. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5609988 Tue, 17 Jan 2012 05:00:00 +0100 5609988 http://www.medworm.com/index.php?rid=5598785&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04627.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5598785 Mon, 16 Jan 2012 05:00:00 +0100 5598785 http://www.medworm.com/index.php?rid=5598784&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04628.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5598784 Mon, 16 Jan 2012 05:00:00 +0100 5598784 http://www.medworm.com/index.php?rid=5598783&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04630.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5598783 Mon, 16 Jan 2012 05:00:00 +0100 5598783 http://www.medworm.com/index.php?rid=5583320&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04624.x Conclusions: UFH monitoring is challenging in infants. Despite their delay in reaching therapeutic anti‐Xa levels, infants monitored by adult‐based anti‐Xa range have a high thrombus resolution rate, no thrombus progression, but a relatively high bleeding rate. Extreme aPTT elevation may contribute to such bleeding risk, particularly in critically ill patients. Current UFH guidelines for young infants may still be inadequate, and laboratory methods with age‐appropriate ranges may be required to further improve clinical outcomes within this population. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5583320 Fri, 13 Jan 2012 05:00:00 +0100 5583320 http://www.medworm.com/index.php?rid=5583328&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04616.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5583328 Wed, 11 Jan 2012 05:00:00 +0100 5583328 http://www.medworm.com/index.php?rid=5583327&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04617.x Conclusions. Seasonal patterns in three haemostatic markers predict at least 8.6% excess CHD mortality in winter in Great Britain, potentially accounting for over half the excess observed in recent years. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5583327 Wed, 11 Jan 2012 05:00:00 +0100 5583327 http://www.medworm.com/index.php?rid=5583326&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04618.x Conclusions: LMWHs with fragments > 10 saccharides and a large number of sulfate groups are more likely to be associated with a higher risk of HIT. These structure‐activity relationships were independent of the ability of the OS to bind antithrombin. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5583326 Wed, 11 Jan 2012 05:00:00 +0100 5583326 http://www.medworm.com/index.php?rid=5583325&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04619.x Conclusion: While FSAP indeed activates scuPA, FVII appears remarkably resistant to activation. Therefore, reappraisal of the putative role of FSAP in haemostasis seems appropriate. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5583325 Wed, 11 Jan 2012 05:00:00 +0100 5583325 http://www.medworm.com/index.php?rid=5583324&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04620.x Conclusion: EC proliferation is initiated very early, and gradually progresses during the organization process of thrombus after coronary plaque disruption, with only limited contribution of primitive cells in this process. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5583324 Wed, 11 Jan 2012 05:00:00 +0100 5583324 http://www.medworm.com/index.php?rid=5583323&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04621.x Conclusion: Exogenous APC improves renal function and mitigates pathological changes in mice with diabetic nephropathy by suppressing the expression of fibrogenic cytokines, growth factors and apoptosis, suggesting its potential usefulness for the therapy of this disease. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5583323 Wed, 11 Jan 2012 05:00:00 +0100 5583323 http://www.medworm.com/index.php?rid=5583322&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04622.x Conclusion. Plasma–derived human AT attenuates ventilator–induced coagulopathy, but not inflammation and bacterial outgrowth in a S. pneumoniae pneumonia model in rats. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5583322 Wed, 11 Jan 2012 05:00:00 +0100 5583322 http://www.medworm.com/index.php?rid=5583321&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04623.x Conclusion: Combination of the APC‐OECA with an aprotinin‐based quenching strategy allowed APC analysis with a limit of detection as low as 0.022 ± 0.005 ng/mL (0.39 ± 0.10 pmol/L) and a limit of quantification of 0.116 ± 0.055 ng/mL (2.06 ± 0.98 pmol/L). While APC plasma levels in healthy individuals fell below the quantifiable range of the APC‐OECA platform, levels substantially increased in patients undergoing hip replacement surgery reaching peak values of up to 12 ng/mL (214 pmol/L). When normalized to the amount of thrombin generated, interindividual variabilities in the APC generating capacity were observed. In general, with a turn‐around time from blood sampling to generation of test results of less than 7 hours, the APC‐OECA platform allows sensitive and rapid dete... Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5583321 Wed, 11 Jan 2012 05:00:00 +0100 5583321 http://www.medworm.com/index.php?rid=5639083&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04647.x Conclusions: Doubling the threshold for a positive D‐dimer with a PE unlikely pretest probability could reduce CTPA scanning with a slightly increased risk of missed isolated subsegmental PE, and no increase in rate of missed pneumonia. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5639083 Sun, 01 Jan 2012 05:00:00 +0100 5639083 http://www.medworm.com/index.php?rid=5620869&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04640.x Conclusions: HNPs activate platelets and induce platelet apoptosis by formation of amyloid‐like proteins. Since these structures entrapped bacteria and fungi, they might reflect an additional function of HNPs in host defense. The described mechanism links again thrombosis and infection. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5620869 Sun, 01 Jan 2012 05:00:00 +0100 5620869 http://www.medworm.com/index.php?rid=5609982&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04639.x Conclusions: Phenotyping of platelet response to clopidogrel was a better predictor of stent thrombosis than genotyping. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5609982 Sun, 01 Jan 2012 05:00:00 +0100 5609982 http://www.medworm.com/index.php?rid=5598782&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04629.x SummaryFour observations support that anticoagulant therapy for venous thromboembolism (VTE) has an “active treatment” phase that is limited to about 3 months. First, less than 3 months of treatment is associated with a higher risk of recurrent VTE than treatment for 3 months or longer, suggesting that less than 3 months is inadequate therapy. Second, treatment for 3 months is associated with the same risk of recurrent VTE as treatment for 6 months or longer, suggesting that 3 months is adequate therapy. Third, the increase in recurrent VTE with too short a course of treatment is predominantly at the site of the initial thrombosis, suggesting reactivation of initial thrombosis. Fourth, the increase in recurrent VTE with too short a course of treatment occurs immediately after treatment... Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5598782 Sun, 01 Jan 2012 05:00:00 +0100 5598782 http://www.medworm.com/index.php?rid=5583319&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2012.04625.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5583319 Sun, 01 Jan 2012 05:00:00 +0100 5583319 http://www.medworm.com/index.php?rid=5572797&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04602.x SummaryClopidogrel is an antithrombotic pro‐drug, whose active metabolite inhibits platelet function by irreversibly binding to the platelet receptor for adenosine diphosphate, P2Y12. Wide inter‐individual variability of response to clopidogrel has been reported in several studies: a significant proportion of treated patients (about 1/3) exhibits a sub‐optimal inhibition of platelet function. Genetic and environmental factors influencing the absorption and/or the extent of metabolism of clopidogrel to its active metabolite account for the observed variability of response. Tailored treatment based on the results of laboratory tests of platelet function has been proposed as a solution to this problem, which has important clinical implications. Although it is often considered a desirabl... Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5572797 Sun, 01 Jan 2012 05:00:00 +0100 5572797 http://www.medworm.com/index.php?rid=5561174&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04592_3.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561174 Sun, 01 Jan 2012 05:00:00 +0100 5561174 http://www.medworm.com/index.php?rid=5561171&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2010.04590.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561171 Sun, 01 Jan 2012 05:00:00 +0100 5561171 http://www.medworm.com/index.php?rid=5561170&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04591.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561170 Sun, 01 Jan 2012 05:00:00 +0100 5561170 http://www.medworm.com/index.php?rid=5561169&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04565.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561169 Sun, 01 Jan 2012 05:00:00 +0100 5561169 http://www.medworm.com/index.php?rid=5561168&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04548.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561168 Sun, 01 Jan 2012 05:00:00 +0100 5561168 http://www.medworm.com/index.php?rid=5561167&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04552.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561167 Sun, 01 Jan 2012 05:00:00 +0100 5561167 http://www.medworm.com/index.php?rid=5561166&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04557.x Conclusions: Increases in the number of microvesicles and in their procoagulant properties, rather than increases in coagulation factors per se, seem to contribute to the risk of VTE, developing during prolonged exposure to air pollutants. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561166 Sun, 01 Jan 2012 05:00:00 +0100 5561166 http://www.medworm.com/index.php?rid=5561165&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04549.x Conclusions: Overall, 96 joint bleeds in 51 patients (> 12 years of age) were dosed. Vatreptacog alfa was well tolerated, with a low frequency of adverse events. No immunogenic or thrombotic events related to vatreptacog alfa were reported. A high efficacy rate of vatreptacog alfa in controlling acute joint bleeds was observed; 98% of bleeds were controlled within 9 h of the initial dose in a combined evaluation of 20–80 μg kg−1 vatreptacog alfa. The efficacy rate observed for rFVIIa (90%) is consistent with data from published clinical trials. The trial was not powered to compare efficacy, and further trials are needed to investigate the efficacy of vatreptacog alfa as compared with that of rFVIIa. The trial was registered at ClinicalTrials.gov (Registration Number: NCT... Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561165 Sun, 01 Jan 2012 05:00:00 +0100 5561165 http://www.medworm.com/index.php?rid=5561164&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04546.x Conclusions: In FV Leiden heterozygotes, the prothrombinase‐based nAPCsr is a marker of VTE risk and is modulated by common F5 SNPs that affect the FVLeiden/normal FV ratio in plasma. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561164 Sun, 01 Jan 2012 05:00:00 +0100 5561164 http://www.medworm.com/index.php?rid=5561163&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04553.x Conclusions: Adding LMWH to aspirin at < 12 weeks gestation reduces recurrent HD onset < 34 weeks gestation in women with inheritable thrombophilia and prior delivery for HD/SGA <34 weeks. However, close monitoring of the mother and fetus remains important throughout pregnancy. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561163 Sun, 01 Jan 2012 05:00:00 +0100 5561163 http://www.medworm.com/index.php?rid=5561162&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04555.x Conclusions: The thromboprophylaxis rate is low, which may be due to the very low incidence of symptomatic VTE after the surgery in Taiwan. Most symptomatic VTE occurred within 2 weeks after the surgery. Universal thromboprophylaxis for knee arthroplasties may not be necessary in Taiwan, but it should be considered in some high‐risk populations. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561162 Sun, 01 Jan 2012 05:00:00 +0100 5561162 http://www.medworm.com/index.php?rid=5561161&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04547.x Conclusions: Differential expression of platelet‐bound and plasma SDF‐1 was observed in patients with AF compared with SR which may be involved in progenitor cell mobilization and inflammatory cell recruitment in patients with AF and ischemic heart disease. Further in vivo studies are required to elucidate the role of SDF‐1 in atrial remodeling and the atrial fibrillation course. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561161 Sun, 01 Jan 2012 05:00:00 +0100 5561161 http://www.medworm.com/index.php?rid=5561160&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04499.x Conclusion: Hemophilia A patients with obesity develop atherosclerosis to a similar extent as the general male population. Detection and treatment of cardiovascular risk factors in hemophilic patients is equally necessary. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561160 Sun, 01 Jan 2012 05:00:00 +0100 5561160 http://www.medworm.com/index.php?rid=5561159&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04514.x Conclusion: Patients with hemophilia are not protected against the development of atherosclerosis as measured by CACS and IMT. The extent of atherosclerosis is related to the traditional cardiovascular risk factors. This suggests that traditional cardiovascular risk factors should be monitored and treated in patients with hemophilia. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561159 Sun, 01 Jan 2012 05:00:00 +0100 5561159 http://www.medworm.com/index.php?rid=5561158&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04542.x See also Zwiers M, Lefrandt JD, Mulder DJ, Smit AJ, Gans ROB, Vliegenthart R, Brands‐Nijenhuis AVM, Kluin‐Nelemans JC, Meijer K. Coronary artery calcification score and carotid intima–media thickness in patients with hemophilia. This issue, pp 23–9; Biere‐Rafi S, Tuinenburg A, Haak BW, Peters M, Huijgen R, de Groot E, Verhamme P, Peerlinck K, Visseren FLJ, Kruip MJHA, Laros‐van Gorkom BAP, Gerdes VEA, Buller HR, Schutgens REG, Kamphuisen PW. Factor VIII deficiency does not protect against atherosclerosis. This issue, pp 30–7. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561158 Sun, 01 Jan 2012 05:00:00 +0100 5561158 http://www.medworm.com/index.php?rid=5561157&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04564.x Summary.  Thromboses that are restricted to the infra‐popliteal deep veins of the lower limbs (isolated distal deep vein thrombosis, IDDVT) are frequently diagnosed in subjects with suspected pulmonary embolism (PE; 7–10%) or DVT (4–15%), accounting for 31–56% of all diagnosed leg DVTs. Despite their frequency, IDDVTs still remain one of the most debated issues in the field of venous thromboembolism (VTE). Conflicting clinical results have resulted in differing opinions on the need to test for IDDVTs and how to treat them. Due to discordant results, the real risk of IDDVT‐associated PE is not well established. IDDVTs are associated with (i) lower risk of recurrence when compared with other VTEs, and (ii) fewer late sequelae than proximal DVT. Diagnosis of IDDVT is based on ultr... Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5561157 Sun, 01 Jan 2012 05:00:00 +0100 5561157 http://www.medworm.com/index.php?rid=5553015&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04614.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5553015 Fri, 30 Dec 2011 05:00:00 +0100 5553015 http://www.medworm.com/index.php?rid=5553014&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04615.x Conclusions: These data show that HFUS assesses venous thrombosis in mice reliably and non‐invasively. Developing a murine model of thrombosis using more accurate, and clinically more relevant techniques such as ultrasonography, is a step towards a better understanding of the pathophysiology of venous thromboembolism. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5553014 Fri, 30 Dec 2011 05:00:00 +0100 5553014 http://www.medworm.com/index.php?rid=5553013&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04612.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5553013 Fri, 30 Dec 2011 05:00:00 +0100 5553013 http://www.medworm.com/index.php?rid=5553022&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04608.x Conclusions: Overall, the presence of AF does not increase the probability of PE when this diagnosis is suspected. Nevertheless, when PE suspicion is based on new‐onset dyspnea, AF significantly decreases the probability of PE, as AF may mimic its clinical presentation. However, in patients with chest pain alone, AF tends to increase PE probability. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5553022 Wed, 28 Dec 2011 05:00:00 +0100 5553022 http://www.medworm.com/index.php?rid=5553021&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04610.x Conclusions: Based on both this work and literature data, we propose a new protocol that needs to be validated on a larger scale before being applied for multicenter studies. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5553021 Wed, 28 Dec 2011 05:00:00 +0100 5553021 http://www.medworm.com/index.php?rid=5553020&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04611.x Conclusions: This study demonstrates comparable safety and effectiveness for two prophylaxis regimens and that prophylaxis significantly reduces bleeding compared to on‐demand treatment. PK‐tailored prophylaxis offers an alternative to standard prophylaxis for the prevention of bleeding. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5553020 Wed, 28 Dec 2011 05:00:00 +0100 5553020 http://www.medworm.com/index.php?rid=5553019&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04605.x Conclusions: These results demonstrate the role of plasticity in regulating fIXa function with respect to discrimination of extended substrate sequences, as well as provide crucial insight into active site modulations that may be capitalized upon by various physiological cofactors of fIXa and in future drug design. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5553019 Wed, 28 Dec 2011 05:00:00 +0100 5553019 http://www.medworm.com/index.php?rid=5553018&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04606.x Conclusions: P2X1 ion channels play a protective role in endotoxemia by negatively regulating systemic neutrophil activation, thereby limiting oxidative response, coagulation and organ damage. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5553018 Wed, 28 Dec 2011 05:00:00 +0100 5553018 http://www.medworm.com/index.php?rid=5553017&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04607.x Conclusions: PHBs are localized on the human platelet membrane and are involved in PAR1‐mediated platelet aggregation. Until recently, PHBs were unknown regulators of PAR1 signaling and may be effective targets for anti‐platelet therapy. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5553017 Wed, 28 Dec 2011 05:00:00 +0100 5553017 http://www.medworm.com/index.php?rid=5553016&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04609.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5553016 Wed, 28 Dec 2011 05:00:00 +0100 5553016 http://www.medworm.com/index.php?rid=5545172&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04603.x Conclusion: The Mon2 ‘intermediate’ subset has unique dynamic and functional characteristics following STEMI and significant correlations with troponin, plasma cytokines and convalescent LV function. The persistent increase in MPA count 30 days after STEMI may affect monocyte subset functional activity. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5545172 Sun, 25 Dec 2011 05:00:00 +0100 5545172 http://www.medworm.com/index.php?rid=5526215&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04601.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5526215 Wed, 21 Dec 2011 05:00:00 +0100 5526215 http://www.medworm.com/index.php?rid=5526218&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04597.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5526218 Tue, 20 Dec 2011 05:00:00 +0100 5526218 http://www.medworm.com/index.php?rid=5526217&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04598.x Conclusions: Venowave devices are effective in preventing VTE in high risk neurosurgical patients. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5526217 Tue, 20 Dec 2011 05:00:00 +0100 5526217 http://www.medworm.com/index.php?rid=5526216&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04599.x Conclusion: Adding an electronic reminder to the admission note improved prophylaxis rates and reduced VTE across services. The system is easily reproducible and applicable to other facilities. The improvement obtained was modest, so additional measures will likely be needed to optimize prophylaxis rates. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5526216 Tue, 20 Dec 2011 05:00:00 +0100 5526216 http://www.medworm.com/index.php?rid=5506068&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04594.x SummaryPost‐thrombotic syndrome (PTS) is a syndrome of chronic venous insufficiency that affects approximately 25% of children following thrombosis involving the deep venous drainage of the limbs. Physical signs in an affected limb may include edema, dilated superficial collateral veins, stasis dermatitis, or skin ulceration. Associated pain, limitation in age‐appropriate activities, or loss of venous access (particularly for the chronically ill child) can cause PTS to be clinically significant. A systematic review of the paediatric deep venous thrombosis literature (mostly consisting of observational studies) recently revealed marked variability in the definition, measurement, reporting (and consequently, observed frequency) of PTS. For clinical trial endpoints such as PTS that are no... Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5506068 Thu, 15 Dec 2011 05:00:00 +0100 5506068 http://www.medworm.com/index.php?rid=5506069&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04593.x Conclusions: These data suggest that ERp57 is important for normal platelet function and opens up the possibility that the regulation of platelet function by a range of cell surface thiol isomerases may represent a broad paradigm for the regulation of haemostasis and thrombosis. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5506069 Tue, 13 Dec 2011 05:00:00 +0100 5506069 http://www.medworm.com/index.php?rid=5487848&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04587.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5487848 Thu, 08 Dec 2011 05:00:00 +0100 5487848 http://www.medworm.com/index.php?rid=5487849&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04581.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5487849 Wed, 07 Dec 2011 05:00:00 +0100 5487849 http://www.medworm.com/index.php?rid=5477369&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04585.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5477369 Tue, 06 Dec 2011 05:00:00 +0100 5477369 http://www.medworm.com/index.php?rid=5477375&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04582.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5477375 Mon, 05 Dec 2011 05:00:00 +0100 5477375 http://www.medworm.com/index.php?rid=5477374&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04583.x Conclusions: Knowledge of thrombophilia status may help to better define the obstetric and thromboembolic risks in asymptomatic family members of women who suffered from obstetric complications. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5477374 Mon, 05 Dec 2011 05:00:00 +0100 5477374 http://www.medworm.com/index.php?rid=5477373&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04584.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5477373 Mon, 05 Dec 2011 05:00:00 +0100 5477373 http://www.medworm.com/index.php?rid=5477372&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04579.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5477372 Mon, 05 Dec 2011 05:00:00 +0100 5477372 http://www.medworm.com/index.php?rid=5477371&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04578.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5477371 Mon, 05 Dec 2011 05:00:00 +0100 5477371 http://www.medworm.com/index.php?rid=5477370&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04580.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5477370 Mon, 05 Dec 2011 05:00:00 +0100 5477370 http://www.medworm.com/index.php?rid=5469762&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04574.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469762 Sat, 03 Dec 2011 05:00:00 +0100 5469762 http://www.medworm.com/index.php?rid=5469761&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04575.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469761 Sat, 03 Dec 2011 05:00:00 +0100 5469761 http://www.medworm.com/index.php?rid=5469760&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04576.x This article focuses on recent insights into the regulation of the cAMP/cGMP signaling network and on new targets of PKA and PKG in platelets. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469760 Sat, 03 Dec 2011 05:00:00 +0100 5469760 http://www.medworm.com/index.php?rid=5553012&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04613.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5553012 Thu, 01 Dec 2011 05:00:00 +0100 5553012 http://www.medworm.com/index.php?rid=5545171&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04604.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5545171 Thu, 01 Dec 2011 05:00:00 +0100 5545171 http://www.medworm.com/index.php?rid=5526214&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04600.x Conclusion: Simple signal processing of the APTT and the use of dynamic parameters represents a stronger predictive marker for hypercoagulation in patients with verified venous thrombosis than the standard APTT measurement. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5526214 Thu, 01 Dec 2011 05:00:00 +0100 5526214 http://www.medworm.com/index.php?rid=5516039&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04596.x Conclusion: Our results indicate that DAG activated ROCE is mediated exclusively by TRPC6 in murine platelets, but this Ca2+ influx has no major functional relevance for hemostasis and thrombosis. Further, in contrast to previous suggestions, based on studies with human platelets, TRPC6 appears to play an insignificant role in the regulation of SOCE in murine platelets. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5516039 Thu, 01 Dec 2011 05:00:00 +0100 5516039 http://www.medworm.com/index.php?rid=5506067&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04595.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5506067 Thu, 01 Dec 2011 05:00:00 +0100 5506067 http://www.medworm.com/index.php?rid=5495469&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04589.x Conclusions: High early sCD40L levels in trauma patients reflect tissue injury, shock, coagulopathy and sympathoadrenal activation and predict mortality. Since sCD40L has pro‐inflammatory activity and activates the endothelium, sCD40L may be involved in trauma induced endothelial damage and coagulopathy. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5495469 Thu, 01 Dec 2011 05:00:00 +0100 5495469 http://www.medworm.com/index.php?rid=5487847&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04588.x Conclusion: An apparently strong association of adherence to the DASH diet with incidence of CVD was attenuated upon control for confounding variables. Adherence to the DASH diet was not associated with risk of VTE in women. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5487847 Thu, 01 Dec 2011 05:00:00 +0100 5487847 http://www.medworm.com/index.php?rid=5477368&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04586.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5477368 Thu, 01 Dec 2011 05:00:00 +0100 5477368 http://www.medworm.com/index.php?rid=5469778&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04560.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469778 Thu, 01 Dec 2011 05:00:00 +0100 5469778 http://www.medworm.com/index.php?rid=5469777&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04559.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469777 Thu, 01 Dec 2011 05:00:00 +0100 5469777 http://www.medworm.com/index.php?rid=5469776&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04521.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469776 Thu, 01 Dec 2011 05:00:00 +0100 5469776 http://www.medworm.com/index.php?rid=5469775&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04519.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469775 Thu, 01 Dec 2011 05:00:00 +0100 5469775 http://www.medworm.com/index.php?rid=5469774&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04535.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469774 Thu, 01 Dec 2011 05:00:00 +0100 5469774 http://www.medworm.com/index.php?rid=5469773&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04489.x See also Greinacher A. Immunogenic but effective: the HIT‐fondaparinux brain puzzler. This issue, pp 2386–8; Warkentin TE, Pai M, Sheppard JI, Schulman S, Spyropoulos AC, Eikelboom JW. Fondaparinux treatment of acute heparin‐induced thrombocytopenia: confirmed by the serotonin‐release assay: a 30‐month, 16‐patient case series. This issue, pp 2389–96. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469773 Thu, 01 Dec 2011 05:00:00 +0100 5469773 http://www.medworm.com/index.php?rid=5469772&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04520.x Conclusions: Our data indicate that these two highly related genes play non‐redundant roles in regulating thrombosis, an observation that supports our previous in vitro murine data, and suggests unique roles, and possibly unique regulation, for PKCα and PKCβ in controlling platelet function in vivo. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469772 Thu, 01 Dec 2011 05:00:00 +0100 5469772 http://www.medworm.com/index.php?rid=5469771&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04532.x Conclusions: Our study has demonstrated that a bacterial protein can induce a conformational change in β2‐GPI, resulting in the formation of antiβ2‐GPI autoantibodies. This constitutes a novel mechanism for the formation of anti‐β2‐GPI autoantibodies. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469771 Thu, 01 Dec 2011 05:00:00 +0100 5469771 http://www.medworm.com/index.php?rid=5469770&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04533.x Conclusions: In patients with a first unprovoked VTE, baseline imaging at completion of anticoagulant therapy helps in interpreting diagnostic tests performed in cases of suspected recurrent VTE. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469770 Thu, 01 Dec 2011 05:00:00 +0100 5469770 http://www.medworm.com/index.php?rid=5469769&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04516.x Conclusions: The economic burden of DVT is substantial. The use of measures to prevent the occurrence of PTS and favoring outpatient care of DVT has the potential to diminish costs. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469769 Thu, 01 Dec 2011 05:00:00 +0100 5469769 http://www.medworm.com/index.php?rid=5469768&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04531.x Conclusions: In HD patients exhibiting HTPR following standard clopidogrel treatment, prasugrel 10 mg day–1 is significantly more efficient than doubling the clopidogrel dosage in achieving adequate platelet inhibition. Neither effect seems to be influenced by carriage of the loss‐of‐function CYP2C19*2 allele. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469768 Thu, 01 Dec 2011 05:00:00 +0100 5469768 http://www.medworm.com/index.php?rid=5469767&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04541.x Conclusions: PON‐1 is an important determinant of clopidogrel antiplatelet efficacy only in patients adequately responding to clopidogrel. These findings may be clinically important in ACS patients receiving clopidogrel therapy, especially the first days after the episode. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469767 Thu, 01 Dec 2011 05:00:00 +0100 5469767 http://www.medworm.com/index.php?rid=5469766&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04513.x Conclusions: This meta‐analysis shows that early upstream administration of abciximab in patients undergoing primary angioplasty for ST‐segment elevation myocardial infarction (STEMI) is associated with significant benefits in terms of pre‐procedural epicardial re‐canalization and ST‐segment resolution, which translates in to significant mortality benefits at long‐term follow‐up. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469766 Thu, 01 Dec 2011 05:00:00 +0100 5469766 http://www.medworm.com/index.php?rid=5469765&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04539.x Conclusions: The incidences of TE and bleeding during CC in children were low. There were no differences between the high‐dose and the low‐dose UFH protocols studied. Although Heparin Anticoagulation Randomized Trial in Cardiac Catheterization (HEARTCAT) was not designed as non‐inferiority trial, low‐dose UFH (50 units kg−1 bolus) appears sufficient for thromboprophylaxis during CC. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469765 Thu, 01 Dec 2011 05:00:00 +0100 5469765 http://www.medworm.com/index.php?rid=5469764&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04523.x Conclusion: In this study, one of the largest to investigate tissue expression of pathophysiologic markers in relation to postoperative AF, we show that more intense expression of VWF by LAA tissue is a significant predictor of postoperative AF. This points towards a possible role of endothelial damage/dysfunction (as reflected by VWF changes) in the pathogenesis of postoperative AF. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469764 Thu, 01 Dec 2011 05:00:00 +0100 5469764 http://www.medworm.com/index.php?rid=5469763&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04517.x Conclusions: Associations between CRP, fibrinogen and t‐PA and metabolic syndrome and its components were stronger in women than in men. Understanding the reasons for these differences across sex will be important in understanding the pathophysiology of cardiovascular and metabolic disease in men and women. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469763 Thu, 01 Dec 2011 05:00:00 +0100 5469763 http://www.medworm.com/index.php?rid=5469759&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04577.x SummaryBackground: The cytoplasmic tails of αIIb and β3 regulate essential αIIbβ3 functions. We previously described a variant Glanzmann thrombasthenia mutation in the β3 cytoplasmic tail, IVS14: ‐3C>G, which causes a frame shift with an extension of β3 by 40 residues. Objectives: The aim of this study was to characterize the mechanism by which the mutation abrogates transition of αIIbβ3 from a resting state to an active state. Methods: We expressed the natural mutation termed 742ins and three artificial mutations in baby hamster kidney (BHK) cells along with wild type (WT) αIIb as follows: β3‐742stop, a truncated mutant to evaluate the effect of deleted residues; β3‐749stop, a truncated mutant that preserves the NPLY conserved sequence; and β3‐749ins, in which the a... Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5469759 Thu, 01 Dec 2011 05:00:00 +0100 5469759 http://www.medworm.com/index.php?rid=5458832&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04571.x This article aims to provide an overview of the dynamic interactions between cellular and molecular components of the bone marrow vascular niche and the potential role of megakaryocytes in bone marrow malignancy. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5458832 Mon, 28 Nov 2011 05:00:00 +0100 5458832 http://www.medworm.com/index.php?rid=5458831&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04570.x Conclusions: Carriers of the CYP2C19*17 variant have greater therapeutic responsiveness to clopidogrel than noncarriers, but they have an increased risk for developing bleeding as well. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5458831 Mon, 28 Nov 2011 05:00:00 +0100 5458831 http://www.medworm.com/index.php?rid=5458830&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04572.x Conclusion: Factors predisposing to peri‐procedural bleeding are primarily patient‐specific. Premature heparin re‐initiation is an avoidable provider‐specific variable to consider. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5458830 Mon, 28 Nov 2011 05:00:00 +0100 5458830 http://www.medworm.com/index.php?rid=5442102&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04568.x Conclusions: The accuracy of POCT coagulometers seems in this respect generally acceptable, and they can be used in a clinical setting. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5442102 Thu, 24 Nov 2011 05:00:00 +0100 5442102 http://www.medworm.com/index.php?rid=5423118&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04565.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5423118 Thu, 17 Nov 2011 05:00:00 +0100 5423118 http://www.medworm.com/index.php?rid=5401331&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04561.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5401331 Sat, 12 Nov 2011 05:00:00 +0100 5401331 http://www.medworm.com/index.php?rid=5401330&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04562.x SummaryParoxysmal Nocturnal Hemoglobinuria (PNH) is a rare acquired disease characterized by a clone of blood cells lacking glycosyl inostitol phosphatidyl (GPI) anchored proteins at the cell membrane. Deficiency of GPI‐anchored complement inhibitors CD55 and CD59 on erythrocytes leads to intravascular hemolysis upon complement activation. Next to hemolysis, another prominent feature is a highly increased risk of thrombosis. Thrombosis in PNH results in high morbidity and mortality. Often, thrombosis occurs at unusual locations, with the Budd‐Chiari syndrome being the most frequent manifestation. Primary prophylaxis with vitamin K antagonists (VKA) reduces the risk, but does not completely prevent thrombosis. Eculizumab, a monoclonal antibody to complement factor C5, effectively reduce... Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5401330 Sat, 12 Nov 2011 05:00:00 +0100 5401330 http://www.medworm.com/index.php?rid=5388699&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04554.x Conclusions: Fucoidan greatly increases ECFC‐mediated angiogenesis in vivo. Its angiogenic effect would be due in part to its transportation to the ischemic site and its release after displacement by proteoglycans present in the extracellular matrix. The use of ECFC and fucoidan together, will be an efficient angiogenesis strategy to provide therapeutic neovascularization. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5388699 Tue, 08 Nov 2011 05:00:00 +0100 5388699 http://www.medworm.com/index.php?rid=5388698&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04556.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5388698 Tue, 08 Nov 2011 05:00:00 +0100 5388698 http://www.medworm.com/index.php?rid=5388697&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04555.x Conclusion: The thromboprophylaxis rate is low, which may be due to the very low incidence of symptomatic VTE after the surgery in Taiwan. Most symptomatic VTE occurred within 2 weeks after the surgery. Universal thromboprophylaxis for knee arthroplasties may not be necessary in Taiwan, but it should be considered in some high‐risk populations. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5388697 Tue, 08 Nov 2011 05:00:00 +0100 5388697 http://www.medworm.com/index.php?rid=5388696&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04557.x Conclusions: Increases in the number of microvesicles and in their procoagulant properties, rather than increases in coagulation factors per se, seem to contribute to the risk of VTE, developing during prolonged exposure to air pollutants. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5388696 Tue, 08 Nov 2011 05:00:00 +0100 5388696 http://www.medworm.com/index.php?rid=5388713&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04549.x Conclusions: Overall, 96 joint bleeds in 51 patients (>12 years of age) were dosed. Vatreptacog alfa was well tolerated, with a low frequency of adverse events. No immunogenic or thrombotic events related to vatreptacog alfa were reported. A high efficacy rate of vatreptacog alfa in controlling acute joint bleeds was observed; 98% of bleeds were controlled within 9 hours of initial dose in a combined evaluation of 20‐80 μg/kg vatreptacog alfa. The efficacy rate observed for rFVIIa (90%) is consistent with data from published clinical trials. The trial was not powered to compare efficacy, and further trials are needed to investigate the efficacy of vatreptacog alfa compared to that of rFVIIa. The trial was registered at ClinicalTrials.gov (Registration Number: NCT00486278). (Sourc... Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5388713 Mon, 07 Nov 2011 05:00:00 +0100 5388713 http://www.medworm.com/index.php?rid=5388702&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04550.x Conclusion: Downregulation of CSQ‐1 in diabetic platelets and impairment of CSQ‐1 in normal cells leads to disturbed Ca2+ release, demonstrating a potential role for CSQ‐1 in the regulation of the platelet Ca2+ release process and a possible causal contributor to diabetic platelet hyperactivity. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5388702 Mon, 07 Nov 2011 05:00:00 +0100 5388702 http://www.medworm.com/index.php?rid=5388701&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04551.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5388701 Mon, 07 Nov 2011 05:00:00 +0100 5388701 http://www.medworm.com/index.php?rid=5388700&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04552.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5388700 Mon, 07 Nov 2011 05:00:00 +0100 5388700 http://www.medworm.com/index.php?rid=5458829&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04573.x Conclusions: No increased risk of death in individuals with thrombophilia, not even in those with a history of thrombosis, was observed. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5458829 Tue, 01 Nov 2011 04:00:00 +0100 5458829 http://www.medworm.com/index.php?rid=5450087&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04553.x Conclusions: Adding LMWH to aspirin at <12 weeks gestation reduces recurrent HD onset <34 weeks gestation in women with inheritable thrombophilia and prior delivery for HD/SGA <34 weeks. Close monitoring of mother and fetus remains important throughout pregnancy. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5450087 Tue, 01 Nov 2011 04:00:00 +0100 5450087 http://www.medworm.com/index.php?rid=5442101&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04569.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5442101 Tue, 01 Nov 2011 04:00:00 +0100 5442101 http://www.medworm.com/index.php?rid=5432429&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04567.x Conclusions: Platelet aggregation and phosphorylation of PLCγ2 induced by collagen was attenuated in ADAP‐/‐ platelets. However, aggregation and signalling induced by CRP, a GpVI selective agonist, was largely unaffected. Platelet adhesion to CRP was also unaffected by ADAP deficiency. Adhesion to the α2β1 selective ligand, GFOGER, and to a peptide (III‐04) which supports adhesion dependent on both GpVI and α2β1 was reduced in ADAP‐/‐ platelets. An impedance‐based label‐free detection technique, which measures adhesion and spreading of platelets, indicated that in the absence of ADAP, spreading on GFOGER was also reduced. This was confirmed using non‐fluorescent differential‐interference contrast microscopy which revealed reduced filpodia formation in ADAP‐/‐ pla... Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5432429 Tue, 01 Nov 2011 04:00:00 +0100 5432429 http://www.medworm.com/index.php?rid=5423117&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04566.x Conclusions: The results of this study confirm that cancers have become a new challenge for physicians working in hemophilia centers and underline the need for prospective trials to better assess the epidemiology and to optimize the management of hemophiliacs with cancer. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5423117 Tue, 01 Nov 2011 04:00:00 +0100 5423117 http://www.medworm.com/index.php?rid=5409567&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04564.x SummaryThromboses limited to the infra‐popliteal deep veins of the lower limbs (Isolated distal deep vein thrombosis, IDDVT) are frequently diagnosed in subjects with suspected pulmonary embolism (PE; 7%‐10%) or DVT (4%‐15%), accounting for 31%‐56% of all diagnosed leg DVTs. Despite their frequency IDDVTs still remain one of the most debated issues in the field of venous thromboembolism (VTE). Conflicting clinical results have prompted differing opinions on the need to test for IDDVTs and to treat them. Due to discordant results the real risk of IDDVT‐associated PE is not well established. IDDVTs are associated with lower risk of recurrence versus other VTEs and less late sequelae than proximal DVT. Diagnosis is based on ultrasound examination of all calf veins, which is more ope... Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5409567 Tue, 01 Nov 2011 04:00:00 +0100 5409567 http://www.medworm.com/index.php?rid=5401329&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04563.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5401329 Tue, 01 Nov 2011 04:00:00 +0100 5401329 http://www.medworm.com/index.php?rid=5388695&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04558.x Conclusions: Dark chocolate inhibits platelet function by lowering oxidative stress only in smokers; this effect seems to be dependent on its polyphenolic content. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5388695 Tue, 01 Nov 2011 04:00:00 +0100 5388695 http://www.medworm.com/index.php?rid=5362596&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2010.04538.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5362596 Tue, 01 Nov 2011 04:00:00 +0100 5362596 http://www.medworm.com/index.php?rid=5362595&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04537.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5362595 Tue, 01 Nov 2011 04:00:00 +0100 5362595 http://www.medworm.com/index.php?rid=5362594&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04500.x See also Biss TT, Avery PJ, Walsh PM, Kamali F. Comparison of ‘time within therapeutic INR range’ with ‘percentage INR within therapeutic range’ for assessing long‐term anticoagulation control in children. J Thromb Haemost 2011; 9: 1090–2; Jones S, Monagle P, Newall F. Comparison of ‘time within therapeutic INR range’ with ‘percentage INR within therapeutic range’ for assessing long‐term anticoagulation control in children: a rebuttal. This issue, pp 2331–2. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5362594 Tue, 01 Nov 2011 04:00:00 +0100 5362594 http://www.medworm.com/index.php?rid=5362593&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04485.x See also Biss TT, Avery PJ, Walsh PM, Kamali F. Comparison of `time within therapeutic INR range' with 'percentage INR within therapeutic range' for assessing long‐term anticoagulation control in children. J Thromb Haemost 2011; 9: 1090–2; Biss TT, Avery PJ, Walsh PM, Kamali F. Comparison of time within therapeutic INR range with percentage INR within therapeutic range for assessing long‐term anticoagulation control in children: reply to a rebuttal. This issue, pp 2332–3. (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5362593 Tue, 01 Nov 2011 04:00:00 +0100 5362593 http://www.medworm.com/index.php?rid=5362592&cid=s_29462_19_f&fid=29462&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1538-7836.2011.04510.x (Source: Journal of Thrombosis and Haemostasis) Journal of Thrombosis and Haemostasis journals http://www.medworm.com/rss/comments.php?id=5362592 Tue, 01 Nov 2011 04:00:00 +0100 5362592