MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Journal of the Cardiometabolic Syndrome' source. Mon, 01 Feb 2010 14:04:33 +0100 http://www.medworm.com/index.php?rid=3052606&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1559-4572.2009.00056.x J Cardiometab Syndr. 2009;4:1[ndash]6. ©2009 Wiley Periodicals, Inc. Obesity and lipid abnormalities in children may increase premature cardiovascular disease risk, but the relationship of dyslipidemia with adiposity among obese children is not well defined. The authors performed a cross-sectional analysis of children and adolescents (N=698) in 3 age groups (3[ndash]8 years, 9[ndash]11 years, and 12[ndash]18 years; 53% female, 81% African American, and 16% Hispanic) attending an obesity treatment program. More than 50% of the sample had abnormal levels of triglycerides (TG) or high-density lipoprotein (HDL) cholesterol or both. Only HDL cholesterol and TG were significantly associated with adiposity measures and insulin resistance (measured by homeostasis model assessment [HOMA]) and only... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=3052606 Thu, 03 Dec 2009 00:00:00 +0100 3052606 http://www.medworm.com/index.php?rid=2223554&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245507%26dopt%3DAbstract Authors: Fergus IV PMID: 19245507 [PubMed - as supplied by publisher] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2223554 Sun, 01 Mar 2009 07:26:55 +0100 2223554 http://www.medworm.com/index.php?rid=2223553&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245508%26dopt%3DAbstract Authors: Kostapanos MS, Liberopoulos EN, Elisaf MS Statins may exhibit significant renoprotective effects beyond their lipid-lowering capacity. Herein, the authors review data from human and animal models of renal disease as well as from studies in cultured renal cells with regard to extralipid renoprotective properties of statins. Statins may exert lipid-independent benefits against renal injury in experimental states of chronic or acute renal function impairment. These include diabetic and hypertensive glomerulosclerosis, autoimmune glomerulonephritis, ischemia/reperfusion-induced renal damage, and unilateral ureteral obstructive nephropathy. Also, statins, by reducing the synthesis of mevalonate products, inhibit the activation of Rho and Ras guanosine triphosphatases that may influ... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2223553 Sun, 01 Mar 2009 07:26:29 +0100 2223553 http://www.medworm.com/index.php?rid=2223552&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245509%26dopt%3DAbstract Authors: Halpert S, McFarlane SI PMID: 19245509 [PubMed - as supplied by publisher] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2223552 Sun, 01 Mar 2009 07:26:23 +0100 2223552 http://www.medworm.com/index.php?rid=2223551&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245510%26dopt%3DAbstract This study suggests that the metabolic syndrome and DM are associated with increased risk of subclinical atherosclerosis. In addition, the presence of the metabolic syndrome or DM with increased FRS has incremental value over the FRS, DM, or the metabolic syndrome alone in predicting significant CAC. PMID: 19245510 [PubMed - as supplied by publisher] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2223551 Sun, 01 Mar 2009 07:26:10 +0100 2223551 http://www.medworm.com/index.php?rid=2223550&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245511%26dopt%3DAbstract Authors: Christian AH, Mochari H, Mosca LJ Total body fat and adipose tissue distribution are associated with cardiometabolic risk, yet there are conflicting data as to whether waist circumference (WC) or body mass index (BMI) is a better predictor of cardiovascular risk. To determine whether WC or BMI was more strongly associated with cardiometabolic risk, family members of patients with cardiac disease were studied (N=501; mean age, 48 years; 66% female; 36% nonwhite). Height, weight, WC, BMI, blood pressure, high-density lipoprotein cholesterol, triglycerides, glucose, high-sensitivity C-reactive protein, and lipoprotein-associated phospholipase A(2) were systematically measured. Global risk was calculated using the Framingham function. Increased WC and BMI were equally strong predi... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2223550 Sun, 01 Mar 2009 07:26:02 +0100 2223550 http://www.medworm.com/index.php?rid=2223549&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245512%26dopt%3DAbstract Authors: Brown TM, Sanderson BK, Bittner V Whether intensive pharmacologic cardiovascular risk factor management reduces metabolic syndrome (MetS) prevalence is unknown. The authors compared the number of secondary prevention medications and National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III)-defined MetS prevalence in coronary artery disease patients entering cardiac rehabilitation from 1996 to 2001 (period 1, n=516) with those entering from 2002 to 2006 (period 2, n=609). Age, sex, and ethnicity were similar in both periods. From period 1 to period 2, participants took more secondary prevention medications (2.8+/-1.3 vs 3.5+/-1.0, P<.001). Prevalence of low high-density lipoprotein cholesterol (66% vs 66%), diabetes (37% vs 38%), and hypertension (81% v... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2223549 Sun, 01 Mar 2009 07:25:53 +0100 2223549 http://www.medworm.com/index.php?rid=2223548&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245513%26dopt%3DAbstract Authors: Can AS, Ozbayrakçı S, Palaoğlu KE, Bersot TP The Turkish Cardiovascular Risk Platform (TCRP) calls for the diagnosis of the metabolic syndrome (MS) if insulin resistance, impaired fasting glucose, impaired glucose tolerance, or diabetes mellitus and >/=2 other established criteria are present. TCRP defines insulin resistance as a homeostasis model assessment >2.7. The aim of this cross-sectional study was to compare TCRP guidelines with the United States National Cholesterol Education Program Adult Treatment Panel III (NCEP) definition of MS in Turkish adults (N=1690). The age- and sex-adjusted prevalence of MS was 25% with the TCRP and 40% for the NCEP definition. Patients with MS identified by the NCEP definition but not by the TCRP definition had lowe... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2223548 Sun, 01 Mar 2009 07:25:43 +0100 2223548 http://www.medworm.com/index.php?rid=2223547&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245514%26dopt%3DAbstract Authors: Narla V, Santos RD, Campbell CY, Carvalho JA, Nasir K, Budoff MJ, Blumenthal RS, Michos ED A number of metabolic syndrome (MS) definitions exist, and one's cardiovascular disease risk may depend on the definition used. The authors compared the association of subclinical atherosclerosis (coronary artery calcification [CAC] score >0] and inflammation (white blood cell [WBC] count greater than or equal to the highest quartile) with 3 definitions of MS (those of the National Cholesterol Education Program Adult Treatment Panel III [NCEP ATP III], the American Heart Association/National Heart, Lung and Blood Institute [AHA/NHLBI], and the International Diabetes Federation [IDF]) in 458 asymptomatic men (mean age, 46+/-7 years). MS was present in 28%, 29%, and 34% according to NCE... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2223547 Sun, 01 Mar 2009 07:25:38 +0100 2223547 http://www.medworm.com/index.php?rid=2223546&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245515%26dopt%3DAbstract Authors: Bevilacqua M, Dominguez LJ, Barbagallo M Highly active antiretroviral therapy (HAART) has dramatically improved the prognosis of HIV-positive patients. However, long-term adverse effects of this therapy include dyslipidemia, insulin resistance (IR), changes in body fat distribution (lipodystrophy), and cardiometabolic syndrome (CMS). IR in HIV-positive patients does not seem to represent a significant independent risk factor for the development of cardiovascular disease; nevertheless, the association with other metabolic complications (dyslipidemia, fat redistribution) and CMS may increase the risk of type 2 diabetes and cardiovascular disease. The use of nucleoside analogue reverse transcriptase inhibitors is associated with the development of upper trunk and visceral fat acc... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2223546 Sun, 01 Mar 2009 07:25:34 +0100 2223546 http://www.medworm.com/index.php?rid=2223545&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245516%26dopt%3DAbstract Authors: Kawano J, Arora R Nearly 1 in 4 adults in the United States is obese. The connection between obesity and insulin resistance, type 2 diabetes, and cardiovascular disease is a well researched one. The increasing prevalence of each of these diseases has become a growing concern for the medical community. Adiponectin is a collagen-like plasma protein secreted by adipocytes that has been suggested to play a causal role in the development of insulin resistance and cardiovascular disease. The protein has been found to be decreased in cases of insulin resistance, diabetes, atherosclerosis, and coronary artery disease. Up-regulation of adiponectin and its receptor, through the use of thiazolidinediones, has been found to be partially related to insulin sensitization and thus antidiabet... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2223545 Sun, 01 Mar 2009 07:25:31 +0100 2223545 http://www.medworm.com/index.php?rid=2223544&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245517%26dopt%3DAbstract Authors: Krishnan S, Short KR Type 1 diabetes (T1D) is a common disease of childhood with a current prevalence of almost 2 cases per 1000 adolescents, according to the third National Health and Nutrition Examination Survey. Modern insulin treatment has resulted in improved quality of life for children with this chronic disorder. However, T1D continues to carry a long-term burden of increased microvascular and macrovascular complications and mortality risk. Compared to the nondiabetic population, patients with T1D are more likely to have >/=1 cardiovascular risk factor and often at an earlier age. Since the prevalence of cardiovascular risk factors increases with age in young persons with T1D, there is a clear need for early screening and counseling to prevent their occurrence and ma... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2223544 Sun, 01 Mar 2009 07:25:26 +0100 2223544 http://www.medworm.com/index.php?rid=2223543&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19245518%26dopt%3DAbstract Authors: Alpert MA, Govindarajan G, Del Rosario ML, Reisin E Chronic kidney disease and cardiovascular disease share many risk factors, including hypertension, obesity, and insulin resistance. All of these are components of the cardiometabolic syndrome and are associated with increased risk of morbidity and mortality. One mechanism that links renal injury with the cardiometabolic syndrome is activation of the renin-angiotensin system. Chronic angiotensin II activation promotes development of renal disease through hemodynamic effects and up-regulation of inflammatory cytokines and growth factors. Inhibition of the renin-angiotensin system delays progression of renal disease and improves measures of renal function independent of blood pressure lowering in patients with the cardiometaboli... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2223543 Sun, 01 Mar 2009 07:25:20 +0100 2223543 http://www.medworm.com/index.php?rid=2006877&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19040586%26dopt%3DAbstract Authors: Alaupovic P, Blackett P, Wang W, Lee E Native Americans are susceptible to type 2 diabetes and associated cardiovascular risk that precedes the diabetes. Nondiabetic Cherokee adolescents and young adults were studied for association of apolipoproteins A-I, B, and C-III with the metabolic syndrome, homeostasis model assessment-insulin resistance (HOMA-IR), and body mass index. Apolipoproteins, lipids, selected ratios, and HOMA-IR changed adversely according to the number of metabolic syndrome criteria present (P<.001 for trend). Logistic regression showed heparin-precipitated apolipoprotein C-III, apolipoprotein C-III bound to apolipoprotein B-containing lipoproteins, to be a significant predictor of the metabolic syndrome in the adolescents and adults, and it appears to be ... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2006877 Wed, 03 Dec 2008 13:51:26 +0100 2006877 http://www.medworm.com/index.php?rid=2006876&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19040587%26dopt%3DAbstract Authors: Nishio K, Shigemitsu M, Kodama Y, Itoh S, Konno N, Satoh R, Katagiri T, Kobayashi Y The aim of this study was to evaluate the effect of pioglitazone on nitric oxide in patients with type 2 diabetes and coronary artery disease. Twenty-seven patients with coronary artery disease and diabetes mellitus who had received coronary stenting were eligible for the study. They were assigned to the no insulin resistance (NIR) group, the insulin resistance (IR) group, and the pioglitazone group (30 mg once a day). Endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-alpha), interleukin-6, leptin, and adiponectin were measured. In the pioglitazone group, eNOS, iNOS, and leptin were significantly lower and adiponectin was signific... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2006876 Wed, 03 Dec 2008 13:51:26 +0100 2006876 http://www.medworm.com/index.php?rid=2006875&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19040588%26dopt%3DAbstract Authors: Coppen AM, Risser JA, Vash PD Without aggressive intervention, childhood obesity and the metabolic syndrome may result in lifelong physical consequences. Interventions that emphasize healthy eating and regular exercise are crucial to stop this epidemic and its ramifications. This paper discusses the incidence of the metabolic syndrome and cardiovascular risk factors before and after a weight loss program. A retrospective review was conducted in 135 children and adolescents (aged 6 to 19) who completed a 10-week medically supervised weight loss program. Outcome measures included mean change in each component of the metabolic syndrome, total cholesterol, low-density lipoprotein cholesterol, and hemoglobin A(1c). After 10 weeks of weight loss, a mean (SD) weight loss of 9.24 (19.... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2006875 Wed, 03 Dec 2008 13:51:26 +0100 2006875 http://www.medworm.com/index.php?rid=2006874&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19040590%26dopt%3DAbstract Authors: Aristizabal D, Gallo J, Fernández R, Restrepo MA, Zapata N, Correa M The relationship between hyperinsulinemia and hypertension is frequently observed in overweight patients; however, population studies have not confirmed an independent association. A population study was conducted to assess whether differences in body mass index and levels of insulinemia modify cardiovascular hemodynamics and arterial pressure. In all, 322 healthy adults underwent a medical evaluation including insulin sensitivity and cardiac performance assessment with echocardiography. A direct relationship between body mass index and blood pressure (r=0.36; P<.01) was shown along with increments in fasting insulin levels. The underlying and progressive rise in insulin levels during blood pressure i... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2006874 Wed, 03 Dec 2008 13:51:26 +0100 2006874 http://www.medworm.com/index.php?rid=2006873&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19040591%26dopt%3DAbstract This study was conducted to determine the prevalence of the metabolic syndrome (MeS) and its associated factors among patients undergoing cardiac catheterization in north Jordan. A cross-sectional study was conducted among patients who underwent cardiac catheterization at King Abdullah University Hospital in north Jordan. Data from 360 patients were collected through personal interview, medical records, and anthropometric measurements. MeS was defined using National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and International Diabetes Federation (IDF) criteria. The prevalence of MeS among patients undergoing cardiac catheterization in north Jordan was 64.7% according to NCEP ATP III criteria and 76.7% according to IDF criteria. About 96.7% of the participants ha... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2006873 Wed, 03 Dec 2008 13:51:26 +0100 2006873 http://www.medworm.com/index.php?rid=2006872&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19040593%26dopt%3DAbstract Authors: Hayden MR, Patel K, Habibi J, Gupta D, Tekwani SS, Whaley-Connell A, Sowers JR Ultrastructural observations reveal a continuous interstitial matrix connection between the endocrine and exocrine pancreas, which is lost due to fibrosis in rodent models and humans with type 2 diabetes mellitus (T2DM). Widening of the islet-exocrine interface appears to result in loss of desmosomes and adherens junctions between islet and acinar cells and is associated with hypercellularity consisting of pericytes and inflammatory cells in T2DM pancreatic tissue. Organized fibrillar collagen was closely associated with pericytes, which are known to differentiate into myofibroblasts-pancreatic stellate cells. Of importance, some pericyte cellular processes traverse both the connecting islet-exocrin... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2006872 Wed, 03 Dec 2008 13:51:26 +0100 2006872 http://www.medworm.com/index.php?rid=2006871&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19040594%26dopt%3DAbstract The objective of this paper is to evaluate the potential health benefits of fish consumption and/or fish oil supplements in reducing cardiometabolic syndrome risk factors. The consumption of fish or fish oil containing omega-3 polyunsaturated fatty acids reduces the risk of coronary heart disease, decreases triglyceride, blood pressure, and inflammatory markers, improves endothelial function, prevents certain cardiac arrhythmias, reduces platelet aggregation (including reactivity and adhesion), reduces vasoconstriction, enhances fibrinolysis, reduces fibrin formation, and decreases the risk of microalbuminuria and sudden cardiac death. Thus, fish intake or fish oil supplement use is beneficial to reduce cardiometabolic risk factors. PMID: 19040594 [PubMed - in process] (Source: Journal... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2006871 Wed, 03 Dec 2008 13:51:26 +0100 2006871 http://www.medworm.com/index.php?rid=2006870&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19040595%26dopt%3DAbstract Authors: Khan KA, Sowers JR Prevalence of overweight and obesity has reached a pandemic proportion worldwide and is increasingly contributing to premature morbidity and mortality. Lifestyle changes including behavioral modification, exercise, different dietary plans, and medications have very poor outcome on long-term weight loss. Bariatric surgery has shown to be very effective for morbidly obese patients. Surgery in these patients not only decreases their body weight but also may improve comorbid conditions associated with obesity. These patients on average lose 61% of excess body weight depending on the procedure performed. Diabetes, hyperlipidemia, and hypertension are normalized in these patients by 77%, 70%, and 62%, respectively. Patients need to be selected carefully for surgic... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2006870 Wed, 03 Dec 2008 13:51:26 +0100 2006870 http://www.medworm.com/index.php?rid=2006869&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19040596%26dopt%3DAbstract Authors: Vrain JS, Bilhorn K, Kurup S, Peterson LR PMID: 19040596 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=2006869 Wed, 03 Dec 2008 13:51:26 +0100 2006869 http://www.medworm.com/index.php?rid=1940165&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18983326%26dopt%3DAbstract Authors: Hayden MR, Sowers JR PMID: 18983326 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1940165 Fri, 07 Nov 2008 15:49:18 +0100 1940165 http://www.medworm.com/index.php?rid=1940164&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18983327%26dopt%3DAbstract The objective of the current study was to examine the prospective association of 3 polymorphisms-a Tth111I restriction fragment in the promoter region, a BclI polymorphism in intron 2, and an A/G polymorphism in exon 2-of the GRL gene on estimates of obesity, hypertension, and diabetes in 163 unrelated Swedish men born in 1944. These data showed a significant increase in body weight, body mass index, abdominal obesity, fasting glucose, insulin, and homeostasis model assessment over the 5-year follow-up among homozygotes for the rare BclI allele. In contrast, no significant associations with the Tth111I or A/G polymorphism were detected. It is concluded that the genetic information about GRL would be useful for further genetic study of obesity, diabetes, and related metabolic diseases. ... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1940164 Fri, 07 Nov 2008 15:49:18 +0100 1940164 http://www.medworm.com/index.php?rid=1940163&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18983328%26dopt%3DAbstract Authors: Lavie CJ, Morshedi-Meibodi A, Milani RV Obesity is a coronary heart disease (CHD) risk factor and is prevalent in patients with CHD. The authors reviewed data in 235 consecutive patients before and after formal cardiac rehabilitation and exercise training (CRET) programs and analyzed data in 72 lean patients (body mass index [BMI] <25 kg/m(2)) vs 73 obese patients (BMI>/=30 kg/m(2)). At baseline, obese patients were significantly younger (P<.0001); had higher percentage of body fat (P<.0001) and more dyslipidemia, including higher triglycerides (TG; P<.01), lower high-density lipoprotein (HDL) cholesterol (P<.0001), and higher TG/HDL ratio (P<.0001); and had higher prevalence of metabolic syndrome (61% vs 26%; P<.01) compared with lean patients. Followi... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1940163 Fri, 07 Nov 2008 15:49:18 +0100 1940163 http://www.medworm.com/index.php?rid=1940162&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18983329%26dopt%3DAbstract Authors: Kashyap SR, Belfort R, Cersosimo E, Lee S, Cusi K Elevated plasma triglyceride/free fatty acid (FFA) levels and insulin resistance may promote atherosclerosis through endothelial activation (ie, increased expression of intercellular adhesion molecule 1 [ICAM-1]/vascular adhesion molecule 1 [VCAM-1], and endothelin-1 [ET-1]) in patients with the metabolic syndrome, but this has never been directly tested. The authors measured endothelial activation and insulin sensitivity (euglycemic insulin clamp with [3-(3)H]-glucose) after a 4-day low-dose lipid infusion that elevated plasma FFA to levels observed in the metabolic syndrome in 20 lean, non-diabetic insulin-resistant subjects with a strong family history of type 2 diabetes mellitus (FH(+)) and 10 insulin-sensitive volunteers w... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1940162 Fri, 07 Nov 2008 15:49:18 +0100 1940162 http://www.medworm.com/index.php?rid=1940161&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18983330%26dopt%3DAbstract Authors: Frohlich ED PMID: 18983330 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1940161 Fri, 07 Nov 2008 15:49:18 +0100 1940161 http://www.medworm.com/index.php?rid=1940160&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18983331%26dopt%3DAbstract This article reviews the histopathophysiologic changes that occur in cardiac structure and function in response to obesity, explores the relationship between obesity and arrhythmias such as atrial fibrillation and sudden cardiac death, and analyzes electrocardiographic changes in an obese patient. PMID: 18983331 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1940160 Fri, 07 Nov 2008 15:49:18 +0100 1940160 http://www.medworm.com/index.php?rid=1940159&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18983332%26dopt%3DAbstract Authors: Artham SM, Lavie CJ, Patel HM, Ventura HO Obesity is becoming a global epidemic in both children and adults, and it is associated with numerous comorbidities such as coronary heart disease, stroke/cerebrovascular disease, type 2 diabetes, hypertension, certain cancers, and sleep-disordered breathing. Over the past 2 decades, the incidence of and mortality from coronary heart disease and cardiovascular diseases has been continuously declining. In contrast, the incidence of and mortality from heart failure (HF) have been increasing, with HF diagnosed in approximately 5 million Americans and 550,000 new cases diagnosed each year and a death rate looming at 300,000 per year. Over the years, conventional risk factors including hypertension, type 2 diabetes, and dyslipidemia have be... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1940159 Fri, 07 Nov 2008 15:49:18 +0100 1940159 http://www.medworm.com/index.php?rid=1940158&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18983333%26dopt%3DAbstract Authors: Todd Miller M, Lavie CJ, White CJ Obesity has a significant adverse effect on coronary heart disease (CHD) risk factors, including hypertension, dyslipidemia, and the metabolic syndrome/diabetes. Obesity is an independent risk factor for CHD events; however, obese patients with CHD generally have a more favorable prognosis, with the worst prognosis associated with either underweight or morbidly obese patients. In this manuscript, the authors review the impact of obesity on overall CHD risk as well as the prognosis of obese patients with established CHD. PMID: 18983333 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1940158 Fri, 07 Nov 2008 15:49:18 +0100 1940158 http://www.medworm.com/index.php?rid=1940157&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18983334%26dopt%3DAbstract Authors: Good D, Morse SA, Ventura HO, Reisin E Controversy exists regarding the amount of risk caused by obesity, but there is general consensus that it is associated with many serious disorders, mostly cardiovascular and neoplastic. Obesity is clearly associated with hypertension, ventricular remodeling with subsequent congestive heart failure, sleep-disordered breathing, and sudden death. The physiologic alterations associated with establishing and perpetuating the obese state are complex but are becoming clear. In discussing the cardiovascular consequences of obesity, the implications and mechanism of the associated hypertension need to be understood. There is growing recognition that adipose tissue is a very active in the neurohormonal axis and is not simply a passive storage depo... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1940157 Fri, 07 Nov 2008 15:49:18 +0100 1940157 http://www.medworm.com/index.php?rid=1940156&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18983335%26dopt%3DAbstract Authors: Witkos M, Uttaburanont M, Lang CD, Arora R The purpose of this literature review was to identify and describe the cost of obesity, the contributing factors, and the use of taxation as a possible method of control of this epidemic in a Canadian setting. A review of the current literature found on the PubMed/MEDLINE services of the National Institutes of Health as well as an analysis of Web content was conducted. The PubMed/MEDLINE search identified 677 articles pertaining to Canada and obesity, 323 articles relating to price policy, 26 articles concerning obesity and taxes, and 29 articles about obesity, Canada, and cost (1964-March 2007). The cost of obesity in Canada has been estimated at $4.3 billion per year, although no yearly figures are available. The contributing factor... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1940156 Fri, 07 Nov 2008 15:49:18 +0100 1940156 http://www.medworm.com/index.php?rid=1940155&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18983336%26dopt%3DAbstract Authors: Wilson PW, Black HR, Fabricatore AN, Goldberg IJ A panel was convened on February 18, 2008, to discuss the challenges to the diagnosis, evaluation, treatment, and management of clustered cardiometabolic risk factors. Peter W.F. Wilson, MD of Emory University School of Medicine, Atlanta, GA, moderated the panel. Henry R. Black, MD, New York University School of Medicine, New York, NY, Anthony N. Fabricatore, PhD, University of Pennsylvania, Philadelphia, PA, and Ira J. Goldberg, MD, Columbia University, New York, NY, participated in the discussion. This expert panel discussion was supported by and each author received an honorarium from Pfizer Inc for time and effort spent participating in the discussion and reviewing the transcript for important intellectual content before pub... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1940155 Fri, 07 Nov 2008 15:49:18 +0100 1940155 http://www.medworm.com/index.php?rid=1940154&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18983337%26dopt%3DAbstract This article discusses the existing data on the interactions between insulin resistance, hyperinsulinemia, and endothelin and how these can lead to renal damage in patients with the cardiometabolic syndrome. PMID: 18983337 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1940154 Fri, 07 Nov 2008 15:49:18 +0100 1940154 http://www.medworm.com/index.php?rid=1940153&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18983338%26dopt%3DAbstract Authors: Wagner DL, Pérez JE, Peterson LR, Rasalingam R PMID: 18983338 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1940153 Fri, 07 Nov 2008 15:49:18 +0100 1940153 http://www.medworm.com/index.php?rid=1564537&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326970%26dopt%3DAbstract Authors: Lang CD, Arora RR, Saha SA, Molnar J The role of angiotensin-converting enzyme (ACE) inhibitors in diabetic patients with preserved ventricular function is uncertain. Tissue ACE inhibitors have been defined by increased lipophilicity and structural characteristics that result in greater tissue-specific ACE binding when compared with plasma ACE inhibitors. A Bayesian meta-analysis of randomized trials was conducted to evaluate tissue ACE inhibitors in prevention of cardiovascular disease among patients with diabetes mellitus and preserved left ventricular function. Four trials were selected that evaluated 2 different ACE inhibitors and included 10,328 patients (43,517 patient-years). The Perindopril Substudy in Coronary Artery Disease and Diabetes (PERSUADE) and the Perindopril... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564537 Thu, 03 Jul 2008 10:57:10 +0100 1564537 http://www.medworm.com/index.php?rid=1564536&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326971%26dopt%3DAbstract Authors: Al-Jaghbeer E, Khraisat A, Singh SP The endocannabinoid system (ECS) is a neuroendocrine system that modulates several cardiometabolic processes. An overactive ECS is implicated as a significant contributor to the cardiometabolic syndrome and obesity, in addition to a large number of other physiologic processes. Endocannabinoid receptors have been detected centrally and peripherally, regulating appetite, food intake, metabolism, and storage. ECS blockade is thought to be a promising new pharmacologic modality of improving the unfavorable metabolic risk profile in patients with the cardiometabolic syndrome and obesity. PMID: 18326971 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564536 Thu, 03 Jul 2008 10:57:10 +0100 1564536 http://www.medworm.com/index.php?rid=1564535&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326972%26dopt%3DAbstract Authors: Bakris G, Molitch M, Zhou Q, Sarafidis P, Champion A, Bacher P, Sowers JR Reversal of new-onset diabetes secondary to thiazide diuretic use remains questionable. STAR-LET was a 6-month extension of the Study of Trandolapril/Verapamil SR and Insulin Resistance (STAR), which assessed the effects of a fixed-dose renin-angiotensin system inhibitor (RASI)/hydrochlorothiazide (HCTZ) combination on changes in 2-hour oral glucose tolerance test (OGTT) results. STAR-LET explored whether the glycemic impact of HCTZ could be reversed by conversion to a RASI/verapamil combination. The primary outcome was change in 2-hour OGTT results. Fifty-one percent of the STAR patients were enrolled in STAR-LET. The 2-hour OGTT value (mmol/L) was unchanged from STAR baseline in the RASI/verapamil grou... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564535 Thu, 03 Jul 2008 10:57:10 +0100 1564535 http://www.medworm.com/index.php?rid=1564534&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326973%26dopt%3DAbstract Authors: Sowers JR PMID: 18326973 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564534 Thu, 03 Jul 2008 10:57:10 +0100 1564534 http://www.medworm.com/index.php?rid=1564533&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326974%26dopt%3DAbstract Authors: Salameh S, Hochner-Celnikier D, Chajek-Shaul T, Manor O, Bursztyn M The authors examined risk factors and extent of coronary artery disease (CAD) among Jewish and Arab women in Jerusalem, where Arab women were found to have worse outcome. All angiographically confirmed cases of CAD among women aged 45 to 65 years who were hospitalized during 1990 to 1995 consisted of 40 Arab and 179 Jewish patients. Arab women had more atypical clinical presentations (P<.0001) and more extensive CAD (P=.0016) despite younger age (53+/-3 vs 55+/-5 years; P<.0003) and lesser smoking (P<.0006). The Arab women, however, were more likely to be obese (80% vs 46%; P=.0002), be physically inactive (100% vs 89%; P=.0285), and have diabetes mellitus (73% vs 40%; P=.0004). Moreover, they were mo... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564533 Thu, 03 Jul 2008 10:57:10 +0100 1564533 http://www.medworm.com/index.php?rid=1564532&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326975%26dopt%3DAbstract Authors: Verdalles U, Cueva Pde L, Verde E, Vinuesa SG, Goicoechea M, Mosse A, Lopez-Gomez JM, Luño J PMID: 18326975 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564532 Thu, 03 Jul 2008 10:57:10 +0100 1564532 http://www.medworm.com/index.php?rid=1564531&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326976%26dopt%3DAbstract Authors: Sierra-Johnson J, Romero-Corral A, Somers VK, Lopez-Jimenez F PMID: 18326976 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564531 Thu, 03 Jul 2008 10:57:10 +0100 1564531 http://www.medworm.com/index.php?rid=1564530&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326977%26dopt%3DAbstract Authors: Hayden MR PMID: 18326977 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564530 Thu, 03 Jul 2008 10:57:10 +0100 1564530 http://www.medworm.com/index.php?rid=1564529&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326978%26dopt%3DAbstract Authors: Ganne S, Winer N Elevated systolic blood pressure and increased pulse pressure are important predictors of vascular stiffening (compliance), left ventricular hypertrophy, coronary heart disease, heart failure, stroke, vascular dementia, and chronic kidney disease. Advances in noninvasive methods that measure arterial stiffness have led to increased understanding of the mechanisms underlying vascular dysfunction and the development of associated risk factors. The ability to detect and monitor changes in the physical properties of arteries has the potential to allow early interventions that may prevent disease or attenuate its progression. In this paper, the authors briefly review the various methods available to measure vascular compliance and review pathologic processes that l... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564529 Thu, 03 Jul 2008 10:57:10 +0100 1564529 http://www.medworm.com/index.php?rid=1564528&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326979%26dopt%3DAbstract Authors: Campbell CY, Nasir K, Carvalho JA, Blumenthal RS, Santos RD Recent studies have shown that elevated white blood cell (WBC) counts independently predict adverse cardiovascular disease (CVD) outcomes. The metabolic syndrome (MS) is known to be associated with a higher degree of inflammation and increased CVD risk. It is unclear, however, whether MS provides incremental information to the Framingham risk score (FRS). The authors studied 458 asymptomatic men, of whom 112 had MS. WBC count was used as a marker of inflammation. The odds ratio (OR) for presence of WBCs in the highest quartile vs the lower 3 quartiles was 2.2; 95% confidence interval (CI), 1.39-3.40 for MS. After further adjustment for the FRS, the relationship remained significant (OR, 1.97; 95% CI, 1.25-3.13). The a... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564528 Thu, 03 Jul 2008 10:57:10 +0100 1564528 http://www.medworm.com/index.php?rid=1564527&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326980%26dopt%3DAbstract Authors: Vaccari CS, Rahman ST, Khan QA, Cheema FA, Khan BV The authors sought to determine whether the angiotensin-converting enzyme (ACE) inhibitor perindopril has beneficial effects on vascular markers of inflammation in patients with the metabolic syndrome when exposed to exercise-induced stress. Thirty patients with the metabolic syndrome were randomized to perindopril (4 mg/d) or placebo in a double-blind fashion for 4 weeks. Prior to treatment, the patients underwent an exercise treadmill study to a level of 8 metabolic equivalents. Circulating monocyte CD11b expression, levels of soluble interleukin 6 (sIL-6), and levels of vascular cell adhesion molecule-1 (VCAM-1) were measured. After the treatment period, exercise treadmill study and measurement of markers were repeated. Tre... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564527 Thu, 03 Jul 2008 10:57:10 +0100 1564527 http://www.medworm.com/index.php?rid=1564526&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326981%26dopt%3DAbstract Authors: , Karam JG, Loney-Hutchinson L, McFarlane SI PMID: 18326981 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564526 Thu, 03 Jul 2008 10:57:10 +0100 1564526 http://www.medworm.com/index.php?rid=1564525&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326982%26dopt%3DAbstract Authors: Hayden MR PMID: 18326982 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564525 Thu, 03 Jul 2008 10:57:10 +0100 1564525 http://www.medworm.com/index.php?rid=1564524&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326983%26dopt%3DAbstract Authors: Zappulla D In the Western world, the prevalence of the metabolic syndrome is increasing exponentially. Chronic subacute inflammation characterizes the syndrome, suggesting that inflammation might be a common denominator that links obesity to its pathologic sequelae. Potential mechanisms for the activation of inflammation include current air pollution inhalation and/or excess food intake. Both of these environmental factors have, in fact, been shown to promote oxidation followed by the release of proinflammatory cytokines. Potential sources of systemic inflammation include oxidized erythrocytes. Increased exogenous or endogenous CO2 deoxygenates hemoglobin, thereby increasing the fraction of hemoglobin reacting with nitrite to form methemoglobin together with release of superox... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564524 Thu, 03 Jul 2008 10:57:10 +0100 1564524 http://www.medworm.com/index.php?rid=1564523&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18326984%26dopt%3DAbstract Authors: Kotliar C, Forcada P, Ferdinand KC PMID: 18326984 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564523 Thu, 03 Jul 2008 10:57:10 +0100 1564523 http://www.medworm.com/index.php?rid=1564522&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18453805%26dopt%3DAbstract Authors: Todd Cade W, Yarasheski KE PMID: 18453805 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564522 Thu, 03 Jul 2008 10:57:10 +0100 1564522 http://www.medworm.com/index.php?rid=1564521&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18453806%26dopt%3DAbstract Authors: Reeds DN Highly active antiretroviral therapy (HAART) has markedly prolonged life expectancy in patients infected with the human immunodeficiency virus (HIV). Use of HAART has been associated with development of a metabolic syndrome that may increase the risk of developing ischemic heart disease. The purpose of this review is to discuss the incidence and clinical manifestations of the metabolic syndrome in patients with HIV infection and contributing factors, as well as whether cardiovascular risk is disproportionately elevated in patients with HIV-associated metabolic syndrome. J Cardiometab Syndr. 2008;3:79-82. PMID: 18453806 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564521 Thu, 03 Jul 2008 10:57:10 +0100 1564521 http://www.medworm.com/index.php?rid=1564520&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18453807%26dopt%3DAbstract The objective of this article is to review the evidence for HIV- and HAART-related left ventricular dysfunction in persons infected with HIV. J Cardiometab Syndr. 2008;3:83-87. PMID: 18453807 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564520 Thu, 03 Jul 2008 10:57:10 +0100 1564520 http://www.medworm.com/index.php?rid=1564519&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18453808%26dopt%3DAbstract Authors: Mondy KE In the era of highly active antiretroviral therapy (HAART), human immunodeficiency virus (HIV) infection has become a chronic disease in which patients may develop significant metabolic complications and risk factors for cardiovascular disease (CVD), including insulin resistance, visceral fat deposition, and increases in atherogenic cholesterol and triglyceride levels. Epidemiologic studies have found that persons infected with HIV are likely to be at higher risk for premature CVD compared with the general population, and clinical studies examining endothelial function in HIV-infected cohorts have supported such conclusions. The mechanisms underlying the regulation of endothelial function in HIV-infected persons appear to be multifactorial, including direct effects of... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564519 Thu, 03 Jul 2008 10:57:10 +0100 1564519 http://www.medworm.com/index.php?rid=1564518&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18453809%26dopt%3DAbstract Authors: Sharma TS, Messiah S, Fisher S, Miller TL, Lipshultz SE Highly active antiretroviral therapy has greatly reduced mortality among human immunodeficiency virus (HIV)-infected patients by delaying, and possibly preventing, progression to AIDS. The risk of cardiovascular disease (CVD) is now an important consideration in these patients and may increase as they live longer. Risk factors for CVD, the inflammatory effects of HIV, and the metabolic complications of antiretroviral therapy may accelerate the onset of CVD. Death from myocardial infarction, however, is still rare compared with death from progression of HIV disease, and the benefits of antiretroviral therapy clearly outweigh any associated risk of CVD. In this review, the authors describe the risk of accelerated CVD in HIV... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564518 Thu, 03 Jul 2008 10:57:10 +0100 1564518 http://www.medworm.com/index.php?rid=1564517&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18453810%26dopt%3DAbstract Authors: Miller TL, Grant YT, Almeida DN, Sharma T, Lipshultz SE Cardiometabolic problems in children with human immunodeficiency virus (HIV) infection have recently begun to emerge as distinct clinical problems that require monitoring and often intervention. The cardiometabolic issues that face HIV-infected children include high rates of unfavorable lipid profiles, insulin resistance, cardiovascular inflammation, and vascular stiffness as well as the phenotypic features of truncal adiposity and facial/extremity wasting. Children differ from adults in that many have been exposed to both HIV and antiretroviral therapies even before birth. The future risk of adverse cardiovascular outcomes is poorly defined yet warrants close tracking because a number of risk factors are present in early... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564517 Thu, 03 Jul 2008 10:57:10 +0100 1564517 http://www.medworm.com/index.php?rid=1564516&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18453811%26dopt%3DAbstract Authors: Mutimura E, Crowther NJ, Stewart A, Todd Cade W The advent of highly active antiretroviral therapy (HAART) has transformed human immunodeficiency virus (HIV)/AIDS into a manageable chronic disorder. Clinical care, however, needs to address the metabolic, anthropometric, and cardiovascular changes associated with HIV infection and HAART. Studies in developing countries suggest an increasing incidence of HIV-associated cardiometabolic syndrome (CMS), especially in urban settings. Predictions indicate that the greatest increase in the prevalence of diabetes will occur in Africa over the next 2 decades due to lifestyle changes. This, coupled with increased access to HAART, may exponentially increase the prevalence of CMS in developing countries, where HIV infection is prevalent. A... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564516 Thu, 03 Jul 2008 10:57:10 +0100 1564516 http://www.medworm.com/index.php?rid=1564515&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18453812%26dopt%3DAbstract Authors: Dorey-Stein Z, Amorosa VK, Kostman JR, Lo Re V, Shannon RP PMID: 18453812 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564515 Thu, 03 Jul 2008 10:57:10 +0100 1564515 http://www.medworm.com/index.php?rid=1564514&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18453813%26dopt%3DAbstract Authors: Bashir A, Laciny E, Lassa-Claxton S, Yarasheski KE PMID: 18453813 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564514 Thu, 03 Jul 2008 10:57:10 +0100 1564514 http://www.medworm.com/index.php?rid=1564513&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18453814%26dopt%3DAbstract Authors: Bakris G, Fonseca V, Foody J A panel was convened on January 10, 2007, to discuss the challenges to the diagnosis, evaluation, treatment, and management of clustered cardiometabolic risk factors. George Bakris, MD, Professor of Medicine, University of Chicago, Chicago, IL, moderated the panel. Vivian Fonseca, MD, Tulane University Health Science Center, New Orleans, LA, and JoAnne Foody, MD, Harvard School of Medicine, Boston, MA, participated in the discussion. This expert panel discussion was supported by and each author received an honorarium from Merck & Co, Inc, and Sanofi-Aventis for time and effort spent participating in the discussion and reviewing the transcript for important intellectual content before publication. The authors maintained full control of the discu... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564513 Thu, 03 Jul 2008 10:57:10 +0100 1564513 http://www.medworm.com/index.php?rid=1564512&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18453815%26dopt%3DAbstract Authors: Brown AL PMID: 18453815 [PubMed - in process] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564512 Thu, 03 Jul 2008 10:57:10 +0100 1564512 http://www.medworm.com/index.php?rid=1564594&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684445%26dopt%3DAbstract Authors: Aradillas-García C, Malacara JM, Garay-Sevilla ME, Guízar JM, Camacho N, De la Cruz-Mendoza E, Quemada L, Sierra JF The authors studied the frequency, distribution, and factors associated with prediabetes (fasting glucose, 100-125 mg/dL) in rural and urban children from San Luis Potosí, León, and Querétaro in central Mexico. Family history, somatometry, and levels of fasting insulin, glucose, and lipids were collected in 1238 children 6 to 13 years of age. The authors found no cases of type 2 diabetes and a 5.7% frequency of prediabetes. The group with prediabetes had higher homeostasis model assessment of insulin resistance scores and total cholesterol and high-density lipoprotein cholesterol levels. Prediabetes was more frequent in León, with si... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564594 Mon, 01 Jan 2007 05:00:00 +0100 1564594 http://www.medworm.com/index.php?rid=1564593&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684446%26dopt%3DAbstract Authors: Yuan G, Hegele RA A well-worn medical aphorism states that "when you hear hoof beats, think of a horse and not a zebra." When applying this principle to the cardiometabolic syndrome (CMS), the horse would be represented by the prevalent CMS phenotype that affects approximately 30% of individuals in Westernized societies, while the zebra is represented by very rare conditions--such as lipodystrophy syndromes--that share some features with the more prevalent CMS. For instance, familial partial lipodystrophy types 2 and 3 result from heterozygous mutations in LMNA, encoding nuclear lamin A/C, and in PPARG, encoding peroxisome proliferator-activated receptor (PPAR)-gamma, respectively. Patients with either subtype of partial lipodystrophy exhibit an increased ratio of central to p... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564593 Mon, 01 Jan 2007 05:00:00 +0100 1564593 http://www.medworm.com/index.php?rid=1564592&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684447%26dopt%3DAbstract Authors: Lorch SM, Sharkey A Childhood obesity is a major health care issue in the United States. This epidemic has important cardiovascular implications. Newer imaging modalities in obese adults have demonstrated abnormal systolic and diastolic cardiac function. The authors proposed to determine whether these abnormalities are present in obese children. A total of 168 children were identified from our echocardiographic database. Body mass index for age was calculated. Echocardiographic clips were analyzed using imaging technology to determine myocardial motion, strain, and strain rate. Patients at risk for obesity and those meeting criteria for obesity had increased late diastolic myocardial motion compared with normal-weight children. Obese patients had decreased systolic strain comp... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564592 Mon, 01 Jan 2007 05:00:00 +0100 1564592 http://www.medworm.com/index.php?rid=1564591&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684448%26dopt%3DAbstract Authors: Dayspring T PMID: 17684448 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564591 Mon, 01 Jan 2007 05:00:00 +0100 1564591 http://www.medworm.com/index.php?rid=1564590&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684449%26dopt%3DAbstract Authors: Rivera JJ, Blumenthal RS, Ashen D Cardiovascular disease claims more lives each year than the other 4 leading causes of death combined. Current prevention and treatment models focus on low-density lipoprotein cholesterol (LDL-C). In 2001, the National Cholesterol Education Program/Adult Treatment Panel III established new risk categories as well as new LDL-C targets especially for high-risk individuals. Since the implementation of these new guidelines, several relevant clinical trials have been published. The results of these trials suggest that lower LDL-C levels confer a more favorable cardiovascular outcome in high-risk individuals. The idea that low levels of LDL-C are related to a halt in atherosclerosis or even plaque regression has been entertained and investigated. Rec... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564590 Mon, 01 Jan 2007 05:00:00 +0100 1564590 http://www.medworm.com/index.php?rid=1564589&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684450%26dopt%3DAbstract Authors: Kleinpeter MA PMID: 17684450 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564589 Mon, 01 Jan 2007 05:00:00 +0100 1564589 http://www.medworm.com/index.php?rid=1564588&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684451%26dopt%3DAbstract Authors: Saeed IM, Barry M, Peterson LR, Gropler RJ PMID: 17684451 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564588 Mon, 01 Jan 2007 05:00:00 +0100 1564588 http://www.medworm.com/index.php?rid=1564587&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684452%26dopt%3DAbstract Authors: Hayden MR PMID: 17684452 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564587 Mon, 01 Jan 2007 05:00:00 +0100 1564587 http://www.medworm.com/index.php?rid=1564586&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684453%26dopt%3DAbstract Authors: Lastra-Lastra G, Lastra-Gonzalez G, Manrique C The dramatic increase in the prevalence of obesity worldwide represents one of the most important challenges of modern medicine, owing to its myriad related complications-in particular cardiovascular disease, the leading cause of death worldwide. Originating from early studies with Cannabis sativa, the active compound of marijuana, there has been an impressive progress in the knowledge about the endocannabinoid network, leading to the identification of specific pathways that modulate feeding behavior. The effects of endocannabinoids are not limited to the central nervous system, but also include peripheral tissues. Experimental and clinic trials have demonstrated the efficacy of endocannabinoid antagonists in the management of obe... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564586 Mon, 01 Jan 2007 05:00:00 +0100 1564586 http://www.medworm.com/index.php?rid=1564585&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684454%26dopt%3DAbstract This study was designed to evaluate whether primary care physicians in Spain accurately diagnose the metabolic syndrome in hypertensive patients, to define the profile and management of these patients in clinical practice, and to ascertain the level of blood pressure and low-density lipoprotein cholesterol control. Data were analyzed from a cross-sectional survey involving 12,954 patients with hypertension (Prevención Cardiovascular en España en Atención Primaria: Intervención Sobre el Colesterol en Hipertensión [PRESCOT] study), wherein 52% of the cohort fulfilled the National Cholesterol Education Program-Adult Treatment Panel criteria for the metabolic syndrome. The majority of patients (54.6%) had 3 risk factors, 32.4% had 4, and 13% had 5 risk factors. Physici... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564585 Mon, 01 Jan 2007 05:00:00 +0100 1564585 http://www.medworm.com/index.php?rid=1564584&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684455%26dopt%3DAbstract Authors: Rundek T, White H, Boden-Albala B, Jin Z, Elkind MS, Sacco RL The metabolic syndrome (MetS) is a distinctive phenotype associated with an increased risk of vascular disease. Carotid plaque is a surrogate marker of subclinical atherosclerosis and a powerful predictor of vascular outcomes. The relationship between the MetS and subclinical atherosclerosis in multiethnic populations has not been well characterized. The authors have evaluated the association of the MetS with subclinical atherosclerosis among 1895 community residents from the Northern Manhattan Study (mean age, 68.0+/-9.7 years; 59% women; 25% black; 22% white; 51% Hispanic). The prevalence of the MetS was 41% (35% in men, 45% in women), and 57% of subjects had carotid plaque. In a multivariate-adjusted logistic reg... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564584 Mon, 01 Jan 2007 05:00:00 +0100 1564584 http://www.medworm.com/index.php?rid=1564583&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684456%26dopt%3DAbstract Authors: Muneyyirci-Delale O, Winer N, Oklander V, Joulak I, Dalloul N, Nacharaju V, Dham S, von Gizycki H Polycystic ovary syndrome (PCOS), one of the most common endocrine disorders in women of reproductive age, has been associated with the cardiometabolic syndrome and increased risk for cardiovascular diseases. Large (C1) and small (C2) vessel compliance and fasting lipids were measured in 45 healthy women and 36 women with PCOS. There were no differences in vacular compliance (C1, C2) between the 2 groups. Systolic blood pressure (116.8 vs 124.3 mm Hg; P=.01), mean arterial pressure (82.5 vs 87 mm Hg; P=.03), and low-density lipoprotein cholesterol (98.1 vs 119 mg/dL; P=.001) were significantly higher in the PCOS group. This difference was not significant after adjusting for age an... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564583 Mon, 01 Jan 2007 05:00:00 +0100 1564583 http://www.medworm.com/index.php?rid=1564582&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684457%26dopt%3DAbstract Authors: Stump CS, Sowers JR, Thomson SP PMID: 17684457 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564582 Mon, 01 Jan 2007 05:00:00 +0100 1564582 http://www.medworm.com/index.php?rid=1564581&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684458%26dopt%3DAbstract Authors: Shargorodsky M, Boaz M, Davidovitz I, Asherov J, Gavish D, Zimlichman R Thiazide diuretics may cause multiple metabolic abnormalities. The authors investigated the effects of varying doses of hydrochlorothiazide (HCTZ) on arterial elasticity and metabolic parameters in patients with hypertension (HTN), HTN and impaired fasting glucose (HTN+IFG), and HTN and type 2 diabetes mellitus (HTN+DM). The patients received low and high doses of HCTZ. Systolic and diastolic blood pressures declined significantly during the first 3 months in all patients, but no additional decrease was seen following the increase in HCTZ dose. In HTN, large artery elasticity index and small artery elasticity increased during the study. In HTN+IFG, large artery elasticity index increased without improvemen... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564581 Mon, 01 Jan 2007 05:00:00 +0100 1564581 http://www.medworm.com/index.php?rid=1564580&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684459%26dopt%3DAbstract Authors: Bulsara KR PMID: 17684459 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564580 Mon, 01 Jan 2007 05:00:00 +0100 1564580 http://www.medworm.com/index.php?rid=1564579&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684460%26dopt%3DAbstract Authors: Ninomiya T, Kiyohara Y Chronic kidney disease is a worldwide public health problem because it is an important risk factor for cardiovascular disease and premature death. The metabolic syndrome, which is characterized by abdominal obesity, high blood pressure, impaired glucose tolerance, and dyslipidemia, is also an increasingly common disorder and a major risk factor for diabetes and cardiovascular disease. A close association has been found between the metabolic syndrome and the risk for developing renal impairment, clinically expressed in the form of microalbuminuria or chronic kidney disease. Several potential mechanisms, including insulin resistance, renal atherosclerosis, and inflammation, induce the deterioration of renal function. Despite the close association between t... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564579 Mon, 01 Jan 2007 05:00:00 +0100 1564579 http://www.medworm.com/index.php?rid=1564578&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684461%26dopt%3DAbstract Authors: Abraham J, Campbell CY, Cheema A, Gluckman TJ, Blumenthal RS, Danyi P C-reactive protein (CRP) is an inflammatory biomarker that is strongly associated with coronary heart disease, inflammation, and the metabolic syndrome. Large-scale prospective cohort trials have shown that measurement of CRP may add predictive accuracy to the Framingham risk score, but interpretation of these data are conflicting. In the primary prevention setting, CRP can be used to reclassify patients in low or intermediate Framingham risk score groups to a higher risk category, thus making them eligible for more intensive pharmacologic interventions. PMID: 17684461 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564578 Mon, 01 Jan 2007 05:00:00 +0100 1564578 http://www.medworm.com/index.php?rid=1564577&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684462%26dopt%3DAbstract Authors: Mulé G, Nardi E, Cottone S, Cusimano P, Palermo A, Incalcaterra F, Giandalia ME, Cerasola G The aim of the study was to cross-sectionally analyze, in a group of essential hypertension patients without diabetes mellitus, the influence of the metabolic syndrome (MS) on the stroke volume index to pulse pressure (SVi/PP) ratio, a measure of total arterial compliance. A total of 528 essential hypertension patients, aged 18 to 72 years, free from cardiovascular and renal disease (41% of whom had MS) were enrolled. All participants underwent routine blood chemistry, echocardiographic examination, and 3 blood pressure measurements at the end of echocardiographic examination. When compared with participants who did not have MS, hypertensive patients with MS exhibited lower SVi/PP ... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564577 Mon, 01 Jan 2007 05:00:00 +0100 1564577 http://www.medworm.com/index.php?rid=1564576&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684463%26dopt%3DAbstract Authors: Thomas JE, Foody JM Diabetes mellitus is a complex disease with several metabolic abnormalities leading to varied, interconnected endothelial and vascular dysfunction and resulting in accelerated atherosclerosis. Cardiovascular disease is the main cause of mortality in patients with diabetes. Apart from traditional therapy for control of hyperglycemia and other associated comorbidities, various newer therapies are being investigated to fight atherosclerosis at a molecular level. In this review, the authors briefly describe the pathophysiology of cardiovascular disease in patients with diabetes mellitus and the future of therapy. PMID: 17684463 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564576 Mon, 01 Jan 2007 05:00:00 +0100 1564576 http://www.medworm.com/index.php?rid=1564575&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684464%26dopt%3DAbstract Authors: Eguchi K, Pickering TG, Kario K Resistance to antihypertensive drugs is common in hypertensive patients with type 2 diabetes. This is unfortunate because hypertension is one of the most important risk factors for development of cardiovascular events, and the goal blood pressure level is set lower in diabetic subjects than in nondiabetic subjects. Previous outcome trials in diabetic subjects have mainly focused on end points such as microalbuminuria or the incidence of cardiovascular events rather than on reduction of blood pressure; some reports, however, have suggested mechanisms for the drug resistance. These include several clinical conditions known to be associated with difficulty in reducing blood pressure specifically in diabetes mellitus: change in the renin-angiotensin... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564575 Mon, 01 Jan 2007 05:00:00 +0100 1564575 http://www.medworm.com/index.php?rid=1564574&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684465%26dopt%3DAbstract Authors: Wright JT PMID: 17684465 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564574 Mon, 01 Jan 2007 05:00:00 +0100 1564574 http://www.medworm.com/index.php?rid=1564573&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684466%26dopt%3DAbstract Authors: Sowers KM, Habibi J, Hayden MR PMID: 17684466 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564573 Mon, 01 Jan 2007 05:00:00 +0100 1564573 http://www.medworm.com/index.php?rid=1564572&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684467%26dopt%3DAbstract Authors: Khan U, Sowers JR PMID: 17684467 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564572 Mon, 01 Jan 2007 05:00:00 +0100 1564572 http://www.medworm.com/index.php?rid=1564571&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684468%26dopt%3DAbstract Authors: Albarracin C, Fuqua B, Geohas J, Juturu V, Finch MR, Komorowski JR Dyslipidemia, often found in type 2 diabetes mellitus (T2DM) patients, plays an important role in the progression of cardiometabolic syndrome. Two essential nutrients, chromium and biotin, may maintain optimal glycemic control. The authors report here a randomized, double-blind placebo-controlled trial (N=348; chromium picolinate and biotin combination [CPB]: 226, placebo: 122; T2DM participants with hemoglobin A1c [HbA1c] >or=7%) evaluating the effects of CPB on lipid and lipoprotein levels. Participants were randomly assigned (2:1 ratio) to receive either CPB (600 microg chromium as chromium picolinate and 2 mg biotin) or a matching placebo once daily for 90 days. Statistical analyses were conducted in all... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564571 Mon, 01 Jan 2007 05:00:00 +0100 1564571 http://www.medworm.com/index.php?rid=1564570&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684469%26dopt%3DAbstract Authors: Schutta MH Diabetes and hypertension frequently coexist, leading to additive increases in the risk of life-threatening cardiovascular events. Hypertension is a common comorbid condition in patients with type 1 or type 2 diabetes when compared with the general population and occurs in 75% of patients with the more prevalent form of diabetes, type 2. Arterial blood pressure plays an important role in the development of renal damage and presents a complex relationship. It is well-known that hypertension accelerates the course of microvascular and macrovascular complications of diabetes and that hypertension often precedes type 2 diabetes and vice versa. Patients with type 1 and 2 diabetes and nephropathy frequently have circadian changes in blood pressure that correlate to nephro... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564570 Mon, 01 Jan 2007 05:00:00 +0100 1564570 http://www.medworm.com/index.php?rid=1564569&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684470%26dopt%3DAbstract Authors: Mariosa LS, Ribeiro-Filho FF, Ribeiro AB, Zanella MT Essential hypertension is a condition of peripheral insulin resistance; thus, fasting plasma glucose level (FPG) alone may not identify glucose tolerance abnormalities. To evaluate the value of an FPG of 100 mg/dL in the detection of these abnormalities in hypertensive women and to identify clinical markers of a high risk of glucose intolerance indicative of further investigation, the authors studied 313 hypertensive women, without known diabetes, in whom an oral glucose tolerance test (OGTT) was performed. The authors demonstrated that FPG alone was not sufficient to identify 27.6% of hypertensive women with glucose intolerance. In this subgroup, the association of waist circumference >or=97 cm and FPG >or=100 mg/dL i... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564569 Mon, 01 Jan 2007 05:00:00 +0100 1564569 http://www.medworm.com/index.php?rid=1564568&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684471%26dopt%3DAbstract Authors: McFarlane SI, Provilus A, Shin JJ PMID: 17684471 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564568 Mon, 01 Jan 2007 05:00:00 +0100 1564568 http://www.medworm.com/index.php?rid=1564567&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684472%26dopt%3DAbstract This article discusses the potential role of oxidative stress as a mediator of the renal effects of insulin resistance/hyperinsulinemia. PMID: 17684472 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564567 Mon, 01 Jan 2007 05:00:00 +0100 1564567 http://www.medworm.com/index.php?rid=1564566&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17684473%26dopt%3DAbstract Authors: Frimel TN, Deivanayagam S, Bashir A, O'Connor R, Klein S PMID: 17684473 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564566 Mon, 01 Jan 2007 05:00:00 +0100 1564566 http://www.medworm.com/index.php?rid=1564564&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17786077%26dopt%3DAbstract Authors: Sowers JR PMID: 17786077 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564564 Mon, 01 Jan 2007 05:00:00 +0100 1564564 http://www.medworm.com/index.php?rid=1564563&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17786078%26dopt%3DAbstract Authors: Kawada T, Otsuka T, Katsumata M, Suzuki H The aim of this study was to examine whether serum uric acid (SUA) concentration was related to the metabolic syndrome (MS). A total of 981 Japanese workingmen were studied. MS was diagnosed based on the modified criteria of the International Diabetes Federation. MS was present in 8.0% of the target participants. Logistic regression analysis using a cutoff value of the SUA of 7.0 mg/dL showed that some components of MS and the logarithmic value of the serum C-reactive protein were associated with a significant odds ratio for predicting elevated SUA. The odds ratios and 95% confidence intervals (CIs) of a high logarithmic value of the serum C-reactive protein, large waist girth, elevated blood pressure, and dyslipidemia for elevated SUA... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564563 Mon, 01 Jan 2007 05:00:00 +0100 1564563 http://www.medworm.com/index.php?rid=1564562&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17786079%26dopt%3DAbstract Authors: Epstein M, Leary E, Laskey R, Zuckerman A, Reed D, Lowe W The current analyses evaluated the effect of atorvastatin on biomarkers of renal function. Serum creatinine level and markers of tubular and glomerular function, including cystatin C, urine N-acetyl-beta-D-glucosaminidase, urine and serum beta2-microglobulin, and urine albumin, were assessed in osteopenic postmenopausal women with mild dyslipidemia who received atorvastatin 20 mg, atorvastatin 80 mg, or placebo for 1 year. During the study, changes in serum creatinine levels were the same in all 3 treatment groups. Cystatin C levels remained unchanged in all groups at all time points. For the additional markers of renal function, median values at baseline and weeks 26 and 52 in both of the atorvastatin and the placebo g... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564562 Mon, 01 Jan 2007 05:00:00 +0100 1564562 http://www.medworm.com/index.php?rid=1564561&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17786080%26dopt%3DAbstract Authors: Kabakci G, Koylan N, Kozan O, Buyukozturk K, Ilerigelen B, The Intensive/Initial Cardiovascular Examination Regarding Blood Pressure Levels: Evaluation of Risk Groups (ICEBERG) study was aimed at evaluating the components of the metabolic syndrome (MS) for cardiovascular risk stratification in hypertensive patients. The ICEBERG study consisted of 2 subprotocols: ICEBERG-1, conducted at 20 university hospitals, and ICEBERG-2, conducted at 197 primary health care centers. Each subprotocol had 2 patient profiles: patients diagnosed with hypertension and receiving medical treatment (treated group) and patients who had not received antihypertensive treatment (untreated group). MS was defined in the Third Report of the National Cholesterol Education Program Adult Treatment Panel as... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564561 Mon, 01 Jan 2007 05:00:00 +0100 1564561 http://www.medworm.com/index.php?rid=1564560&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17786081%26dopt%3DAbstract Authors: Stern N, Osher E, Greenman Y Adiponectin is the most abundantly secreted adipocyte-derived peptide hormone, possessing an array of antidiabetogenic and cardiovascular protective effects. Acting through 2 distinct membrane receptors, adiponectin receptors 1 and 2 (which utilize 5'-adenosine monophosphate-activated protein kinase phosphorylation, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha as key cell signaling elements), adiponectin increases hepatic and skeletal muscle sensitivity to insulin, enhances fatty acid oxidation, suppresses monocyte-endothelial interaction, supports endothelial cell growth, lowers blood pressure, and moderates adipose tissue growth. The secretion of adiponectin can be suppressed by adipose factors, which... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564560 Mon, 01 Jan 2007 05:00:00 +0100 1564560 http://www.medworm.com/index.php?rid=1564559&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17786082%26dopt%3DAbstract Authors: Dominguez LJ, Barbagallo M The aging of the world's population is a major contributor to the growing prevalence of the cardiometabolic syndrome (CMS) because older persons are more affected by the constellation of cardiovascular risk factors that constitute the syndrome. The prevalence of CMS has been related to the increasing prevalence of obesity, which is growing progressively even among older age groups. Indeed, obesity and aging are 2 overlapping mounting public health problems. It is currently accepted that CMS predicts cardiovascular mortality and/or the development of type 2 diabetes mellitus, and this is also true in studies including older persons. CMS is further complicated by modifications in body composition and fat redistribution during aging; older adults are at... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564559 Mon, 01 Jan 2007 05:00:00 +0100 1564559 http://www.medworm.com/index.php?rid=1564558&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17786083%26dopt%3DAbstract Authors: Jain P, Lahiri A Cardiovascular disease is an escalating worldwide health problem. Effective tools to predict and prevent its development and progression are needed. Correctly diagnosing the metabolic syndrome, which identifies people at higher risk for developing diabetes mellitus and cardiovascular disease, may be valuable in guiding treatment and prevention of these major disorders. Several important definitions of the metabolic syndrome have been proposed. The authors discuss these definitions and how they vary in terms of their relationship to incident cardiovascular disease, type 2 diabetes mellitus, and surrogate markers of atherosclerosis. Establishing clarity on what is meant by the metabolic syndrome and agreement as to its underlying basis is needed to reach consens... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564558 Mon, 01 Jan 2007 05:00:00 +0100 1564558 http://www.medworm.com/index.php?rid=1564557&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17786084%26dopt%3DAbstract Authors: Duggal J, Singh S, Barsano CP, Arora R Previous studies have suggested that subclinical thyroid dysfunction, as manifested by abnormalities in thyroid-stimulating hormone (TSH) levels, are associated with detrimental effects on the cardiovascular system. Subclinical hypothyroidism is characterized by abnormal lipid metabolism, cardiac dysfunction, diastolic hypertension conferring an elevated risk of atherosclerosis, and ischemic heart disease. Similarly, patients with subclinical hyperthyroidism have nearly 3 times the likelihood of atrial fibrillation over a 10-year follow-up interval, raising the question of whether patients with subclinical hyperthyroidism should be treated to prevent atrial fibrillation. A single measurement of low serum TSH in individuals aged 60 years o... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564557 Mon, 01 Jan 2007 05:00:00 +0100 1564557 http://www.medworm.com/index.php?rid=1564556&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17786085%26dopt%3DAbstract Authors: Sowers JR, Bakris GL, Black HR, Giles TD On April 18, 2007, a panel was convened to discuss the metabolic syndrome and its relationship to the renin-angiotensin system. James R. Sowers, MD, Professor of Medicine and Physiology and Director of the Diabetes Research Center, University of Missouri-Columbia, Columbia, moderated the panel. George L. Bakris, MD, Professor of Medicine, University of Chicago, Chicago, IL; Henry R. Black, MD, Clinical Professor of Internal Medicine, New York University School of Medicine, New York, NY; and Thomas D. Giles, MD, Professor of Medicine, Tulane University School of Medicine, New Orleans, LA, participated in the discussion. This expert panel discussion was supported by Novartis and each author received an honorarium from Novartis for time an... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564556 Mon, 01 Jan 2007 05:00:00 +0100 1564556 http://www.medworm.com/index.php?rid=1564555&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17786086%26dopt%3DAbstract Authors: Watson RE PMID: 17786086 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564555 Mon, 01 Jan 2007 05:00:00 +0100 1564555 http://www.medworm.com/index.php?rid=1564554&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17786087%26dopt%3DAbstract Authors: Saeed IM, Rao PM, Barzilai B, Woodard PK PMID: 17786087 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564554 Mon, 01 Jan 2007 05:00:00 +0100 1564554 http://www.medworm.com/index.php?rid=1564553&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17804949%26dopt%3DAbstract Authors: Karuparthi PR, Yerram P, Gupta D, Hayden MR PMID: 17804949 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564553 Mon, 01 Jan 2007 05:00:00 +0100 1564553 http://www.medworm.com/index.php?rid=1564552&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059203%26dopt%3DAbstract Authors: Lastra-Gonzalez G, Manrique-Acevedo C, Sowers JR PMID: 18059203 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564552 Mon, 01 Jan 2007 05:00:00 +0100 1564552 http://www.medworm.com/index.php?rid=1564551&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059204%26dopt%3DAbstract Authors: Ferdinand KC PMID: 18059204 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564551 Mon, 01 Jan 2007 05:00:00 +0100 1564551 http://www.medworm.com/index.php?rid=1564550&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059205%26dopt%3DAbstract Authors: Davidson JA, Kannel WB, Lopez-Candales A, Morales L, Moreno PR, Ovalle F, Rodriguez CJ, Rodbard HW, Rosenson RS, Stern M Cardiovascular disease (CVD) is the leading cause of death among the largest and fastest growing ethnic minority in the United States, Latinos/Hispanics. To review recent findings on the prevalence of CVD, CVD risk factors, and related illnesses in the US Latino/Hispanic population, an extensive PubMed and Internet literature search for studies published from January 1995 to July 2005 was conducted, using a combination of search terms. Data validity was assessed based on the quality of the source and a consensus of the authors on perceived validity. The review found limitations in current research as well as treatment methods and options for Latino/Hispanic ... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564550 Mon, 01 Jan 2007 05:00:00 +0100 1564550 http://www.medworm.com/index.php?rid=1564549&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059206%26dopt%3DAbstract Authors: Ebbesson SO, Tejero ME, Nobmann ED, Lopez-Alvarenga JC, Ebbesson L, Romenesko T, Carter EA, Resnick HE, Devereux RB, MacCluer JW, Dyke B, Laston SL, Wenger CR, Fabsitz RR, Comuzzie AG, Howard BV Fatty acids (FAs) have been related to changes in glucose and lipid metabolism. In this article, the authors assess the association between intake of specific FAs and components of the metabolic syndrome (MS) in adult Eskimos. A total of 691 Inupiat Eskimos (325 men and 366 women), aged 34 to 75 years, were examined as part of the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. The investigation included a physical examination, blood pressure measurements, blood sampling under fasting conditions, 2-hour oral glucose tolerance test, and a personal interview includ... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564549 Mon, 01 Jan 2007 05:00:00 +0100 1564549 http://www.medworm.com/index.php?rid=1564548&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059207%26dopt%3DAbstract This study examined 2005-2006 data on CVD mortality and risk factors to see if disparities experienced historically by Native Hawaiians have continued, increased, or been reduced. Existing data were reviewed related to CVD and risk factors for Native Hawaiians in Hawaii and compared with statewide and US rates. These data show that Native Hawaiians are experiencing continuing and perhaps growing disparities in CVD mortality rates and risk factor prevalence. Nevertheless, increased support for enlightened social policy and community-directed problem solving can help reduce CVD health disparities experienced by Native Hawaiians. Future research should be directed at better delineation of the various components of cardiometabolic risk and culturally sensitive, and educationally appropriate ap... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564548 Mon, 01 Jan 2007 05:00:00 +0100 1564548 http://www.medworm.com/index.php?rid=1564547&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059208%26dopt%3DAbstract This study investigated the role of relative androgen excess, designated by low sex hormone-binding globulin (SHBG), on development of type 2 diabetes in premenopausal African American women. A prospective, longitudinal study was conducted on premenopausal African American women, initially aged 36 to 43 years (n=119). Patients were reexamined 8 years later to determine whether initial androgen status was associated with insulin resistance and development of diabetes. Among patients in the low SHBG tertile, 18% converted to type 2 diabetes by the second examination, as compared with 5% in the mid SHBG tertile and 2.5% in the high SHBG tertile (P=.04). Insulin sensitivity was significantly different among the 3 tertiles (P<.01). There was no significant difference in total cholesterol, hi... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564547 Mon, 01 Jan 2007 05:00:00 +0100 1564547 http://www.medworm.com/index.php?rid=1564546&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059209%26dopt%3DAbstract Authors: Schuster DP, Gaillard T, Osei K Unique genetic traits appear to play a role in the increased rates of hypertension (HTN), glucose dysregulation/diabetes (T2DM), and obesity in persons of African descent. Indeed, with increasing rates of westernization/urbanization and concomitant increases in obesity and T2DM, a similar predisposition to the cardiometabolic syndrome and cardiovascular disease (CVD) can be seen in Africans compared with persons of African descent, with CVD reaching epidemic proportions in many areas of Africa. In addition, the complex relationships of metabolic abnormalities that are unique to individuals of African descent have also been demonstrated in Africans. These include: (1) a dissociation of HTN to insulin resistance; (2) relative favorable lipid profi... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564546 Mon, 01 Jan 2007 05:00:00 +0100 1564546 http://www.medworm.com/index.php?rid=1564545&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059210%26dopt%3DAbstract Authors: Enas EA, Mohan V, Deepa M, Farooq S, Pazhoor S, Chennikkara H South Asians have high rates of diabetes and the highest rates of premature coronary artery disease in the world, both occurring about 10 years earlier than in other populations. The metabolic syndrome (MS), which appears to be the antecedent or "common soil" for both of these conditions, is also common among South Asians. Because South Asians develop metabolic abnormalities at a lower body mass index and waist circumference than other groups, conventional criteria underestimate the prevalence of MS by 25% to 50%. The proposed South Asian Modified National Cholesterol Education Program criteria that use abdominal obesity as an optional component and the South Asian-specific waist circumference recommended by the Int... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564545 Mon, 01 Jan 2007 05:00:00 +0100 1564545 http://www.medworm.com/index.php?rid=1564544&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059211%26dopt%3DAbstract Authors: Hoang KC, Le TV, Wong ND The metabolic syndrome is an emerging epidemic in developing nations, including East Asian countries such as China, Japan, and Korea. Studies examining the metabolic syndrome have used different definitions, with prevalence often highly dependent on the cut points for abdominal obesity utilized, which have been recommended by the International Diabetes Federation to be lower than standards used in Caucasians and other ethnic groups. Prevalence rates have generally varied from 8% to 13% in men and 2% to 18% in women, depending on ethnic group and definition used, and are consistently lower than most Western Caucasian populations. While recent dramatic changes in lifestyle from Westernization of dietary habits and reduced physical activity present challe... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564544 Mon, 01 Jan 2007 05:00:00 +0100 1564544 http://www.medworm.com/index.php?rid=1564543&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059212%26dopt%3DAbstract Authors: Russell M, de Simone G, Resnick HE, Howard BV Although the underlying cause of the metabolic syndrome (MS) is not entirely clear, it is thought that MS results from central obesity and insulin resistance (IR). IR has long been known to be a predictor of type 2 diabetes in many populations, including American Indians, the group with a rising prevalence of obesity and the highest rate of diabetes in the United States. In addition to being a predictor of diabetes, MS has now been shown to be associated with higher risk of cardiovascular disease, independent of diabetes, in American Indians as well as in other ethnic groups. Furthermore, MS may carry a risk beyond that of single risk factors. Identifying MS in American Indians and treating the factors that comprise it may reduce r... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564543 Mon, 01 Jan 2007 05:00:00 +0100 1564543 http://www.medworm.com/index.php?rid=1564542&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059213%26dopt%3DAbstract Authors: Stern N, Osher E, Greenman Y Low adiponectin expression is common in obesity and is tightly linked to insulin resistance and fat mass expansion. Whereas normal adipocytes offer effective metabolic buffering through well-controlled release and uptake of free fatty acids on demand, adipocyte expansion induced by caloric excess and modulated by genetic, regional, and systemic factors elicits major unfavorable changes in fat cell phenotypes. Large, dysfunctional adipocytes show increased lipolysis and enhanced expression and secretion of proinflammatory and pro-oxidative cytokines. Low adiponectin secretion is a hallmark of impaired adipocyte function; its secretion is inhibited by cytokines such as tumor necrosis factor alpha, interleukin 6 and plasminogen activator inhibitor 1 a... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564542 Mon, 01 Jan 2007 05:00:00 +0100 1564542 http://www.medworm.com/index.php?rid=1564541&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059214%26dopt%3DAbstract Authors: Stafylas PC, Sarafidis PA, Lasaridis AN PMID: 18059214 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564541 Mon, 01 Jan 2007 05:00:00 +0100 1564541 http://www.medworm.com/index.php?rid=1564540&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059215%26dopt%3DAbstract Authors: Sarafidis PA Diabetic nephropathy is an important public health issue and a major challenge for modern nephrology, as it is the primary cause of end-stage renal disease. In addition to established risk factors for diabetic nephropathy progression (ie, hyperglycemia and hypertension), current knowledge suggests that other factors can be involved. Population studies show that insulin resistance and hyperinsulinemia are also associated with chronic kidney disease, and several background mechanisms could explain this relationship. The hypoglycemic class of thiazolidinediones that act through reduction of insulin resistance were found to protect against renal injury in diabetic animals and to reduce urinary albumin excretion in patients with type 2 diabetes and microalbuminuria. Th... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564540 Mon, 01 Jan 2007 05:00:00 +0100 1564540 http://www.medworm.com/index.php?rid=1564539&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059216%26dopt%3DAbstract Authors: Ferdinand KC, Pacini RS TJ is a 57-year-old female high school biology teacher who presents for a routine checkup. She has a strong family history of heart disease and wants to ensure that she does everything possible to keep her risk low. TJ is postmenopausal and stopped hormone replacement therapy 3 years ago. Physical examination is unremarkable other than the fact that the patient is overweight, with a body mass index of 29.2 kg/m2, and her blood pressure (BP) is 132/84 mm Hg. Her fasting plasma glucose level is 103 mg/dL, high-density lipoprotein cholesterol level 38 mg/dL, and triglyceride level 165 mg/dL. Based on her BP and concurrent cardiometabolic syndrome, what do you tell her about the risks associated with her BP, and how do you approach her management? PMID:... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564539 Mon, 01 Jan 2007 05:00:00 +0100 1564539 http://www.medworm.com/index.php?rid=1564538&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18059217%26dopt%3DAbstract Authors: Delcour KS, Tejwani L, Hayden MR, Govindarajan G PMID: 18059217 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564538 Mon, 01 Jan 2007 05:00:00 +0100 1564538 http://www.medworm.com/index.php?rid=1564611&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679817%26dopt%3DAbstract Authors: Gonzalez GL, Manrique CM, Sowers JR Diabetes mellitus confers a high risk of cardiovascular morbidity and mortality and requires aggressive management of all cardiovascular risk factors, including diabetic dyslipidemia. Although levels of low-density lipoprotein cholesterol are often normal or only slightly elevated in persons with diabetes, lipid-altering therapy with statins has been shown in large, randomized, controlled trials to decrease the risk of cardiovascular complications in this patient population. A target low-density lipoprotein cholesterol level of <70 mg/dL is now a therapeutic option in patients at very high risk for coronary heart disease, including patients with diabetes. Diabetes is also a leading cause of end-stage renal disease. In addition to their li... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564611 Sun, 01 Jan 2006 05:00:00 +0100 1564611 http://www.medworm.com/index.php?rid=1564610&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679818%26dopt%3DAbstract Authors: Govindarajan G, Chowdhury N, Flaker G PMID: 17679818 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564610 Sun, 01 Jan 2006 05:00:00 +0100 1564610 http://www.medworm.com/index.php?rid=1564609&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679819%26dopt%3DAbstract Authors: Whaley-Connell A, Pavey BS, Afroze A, Bakris GL The cardiometabolic syndrome is a state of metabolic and vascular dysregulation. The cardiometabolic syndrome is clinically composed of a cluster of metabolic abnormalities including insulin resistance/hyperinsulinemia, central/visceral obesity, dyslipidemia, hypertension, microalbuminuria, fibrinolytic and inflammatory abnormalities, endothelial dysfunction, oxidative stress, and hypercoagulability, which collectively lead to an increased risk of cardiovascular and renal outcomes. The development of microalbuminuria is now accepted as a marker of systemic endothelial dysfunction and, if it progresses to macroalbuminuria (i.e., >200 mg/d albuminuria), then kidney disease is evident. Collectively, visceral obesity, insulin resi... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564609 Sun, 01 Jan 2006 05:00:00 +0100 1564609 http://www.medworm.com/index.php?rid=1564608&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679820%26dopt%3DAbstract Authors: Thyfault JP, Rector RS, Noland RC Peripheral insulin resistance, which is largely dependent on skeletal muscle, is closely linked to the development of the cardiometabolic syndrome. Metabolic flexibility is the capacity for skeletal muscle to acutely shift its reliance between lipids or glucose during fasting or postprandial conditions. Obese and insulin-resistant individuals display elevated intramuscular lipids, impaired vasculature function, decreased fatty add oxidation during fasting, and reduced postprandial glucose metabolism. Impairments in metabolic flexibility are linked to physical inactivity, excess energy intake and obesity, and genetic predisposition. Each of these factors precludes the development of insulin resistance and the cardiometabolic syndrome by mechani... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564608 Sun, 01 Jan 2006 05:00:00 +0100 1564608 http://www.medworm.com/index.php?rid=1564607&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679821%26dopt%3DAbstract Authors: Hayden MR PMID: 17679821 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564607 Sun, 01 Jan 2006 05:00:00 +0100 1564607 http://www.medworm.com/index.php?rid=1564606&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679822%26dopt%3DAbstract Authors: Hayden MR, Chowdhury NA, Witte L, Sowers JR Microalbuminuria is a simple screening test that is not only associated with an increased risk of progressive renal insufficiency, but also an increased risk of cardiovascular disease and stroke in the cardiometabolic syndrome. The role of oxidative stress, inflammation, and cellular-extracellular matrix remodeling fibrosis is very important, and the authors have previously observed that albuminuria is related, in part, to loss of the integrity of the glomerular filtration apparatus. The proximal tubule may play a more important role than previously thought, as it is estimated that in health this portion of the nephron reabsorbs 5-8 g of albumin that normally leaks through the glomerulus on a daily basis. Recently, the authors have m... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564606 Sun, 01 Jan 2006 05:00:00 +0100 1564606 http://www.medworm.com/index.php?rid=1564605&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679823%26dopt%3DAbstract Authors: Wong ND, Gransar H, Shaw LJ, Polk D, Berman DS The cardiometabolic syndrome (CMS) and diabetes are associated with higher cardiovascular risk. The authors compared the association of CMS risk factors and diabetes with coronary and aortic calcium. A total of 4468 adults (42% female) underwent computed tomography for determination of coronary artery calcium (CAC) and thoracic aortic calcium (TAC) and were classified according to the presence of diabetes mellitus (DM) and number of CMS risk factors. The prevalence of CAC ranged from 51% in men and 35% in women with neither DM nor CMS to 75% in men and 58% in women with both DM and CMS, whereas TAC ranged from 29% to 44% in men and 36% to 55% in women. Women with four or five CMS risk factors more often had CAC (53%) and TAC (51%)... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564605 Sun, 01 Jan 2006 05:00:00 +0100 1564605 http://www.medworm.com/index.php?rid=1564604&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679824%26dopt%3DAbstract Authors: Weinberger MH PMID: 17679824 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564604 Sun, 01 Jan 2006 05:00:00 +0100 1564604 http://www.medworm.com/index.php?rid=1564603&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679825%26dopt%3DAbstract Authors: Bursztyn M, Ariel I Epidemiologic studies suggest a relationship between low birth weight and adverse cardiovascular outcomes. Risk factors such as obesity, insulin resistance, diabetes mellitus, and hypertension--the cardiometabolic syndrome--are similarly affected. These observations are now supported by numerous animal studies. The mechanisms linking low birth weight and the cardiometabolic syndrome later in life appear to be multifactorial and involve alterations in the normal cellular and physiologic systems associated with growth in an unfavorable environment. Such "fetal programming," an adaptation to a shortage of nutrients, may bring about maladaptation upon postnatal exposure to an abundance of nutrients. This review briefly summarizes the adaptive responses in vario... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564603 Sun, 01 Jan 2006 05:00:00 +0100 1564603 http://www.medworm.com/index.php?rid=1564602&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679826%26dopt%3DAbstract Authors: Ndumele CE, Pradhan AD, Ridker PM The recognition that inflammation plays a fundamental role in atherothrombosis has led to the measurement of circulating inflammatory biomarkers such as high-sensitivity C-reactive protein (hs-CRP) as a means of improving cardiovascular disease detection and prevention. Clinically, levels of hs-CRP >3 mg/L indicate elevated risk for myocardial infarction and stroke, even among apparently healthy individuals with low-to-normal lipid levels. Emerging laboratory and epidemiologic data now link inflammation and hs-CRP to insulin resistance in that hs-CRP levels have been associated with impaired insulin sensitivity and the development of dysglycemic conditions, including the cardiometabolic syndrome and incident type 2 diabetes. hs-CRP has also... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564602 Sun, 01 Jan 2006 05:00:00 +0100 1564602 http://www.medworm.com/index.php?rid=1564601&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679827%26dopt%3DAbstract Authors: Ogedegbe G PMID: 17679827 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564601 Sun, 01 Jan 2006 05:00:00 +0100 1564601 http://www.medworm.com/index.php?rid=1564600&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679828%26dopt%3DAbstract Authors: Ferdinand KC The potential benefit of drug therapy for prehypertension and the cardiometabolic syndrome has previously not been confirmed. This case represents a patient who may show slowing or avoiding progression from prehypertension to hypertension based on recent trial evidence and assists the clinician in identifying the risk associated with blood pressure elevation before a conventional cut point of 140/90 mm Hg. PMID: 17679828 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564600 Sun, 01 Jan 2006 05:00:00 +0100 1564600 http://www.medworm.com/index.php?rid=1564599&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679829%26dopt%3DAbstract Authors: Kabakov E, Norymberg C, Osher E, Koffler M, Tordjman K, Greenman Y, Stern N The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) has recommended a downward shift in target blood pressure to <130/80 mm Hg in diabetic patients, thus operatively setting a new threshold level for the definition of hypertension at 130/80 mm Hg.The authors performed a retrospective chart analysis of 2227 type 2 diabetes patients treated in one hospital-based and two community-based clinics in central Israel to determine the prevalence of hypertension as a function of three diagnostic threshold levels.The prevalence of hypertension in this cohort was 60.2%, 76.5%, and 85.8% at blood pressure thresholds of 140/90, 130/... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564599 Sun, 01 Jan 2006 05:00:00 +0100 1564599 http://www.medworm.com/index.php?rid=1564598&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679830%26dopt%3DAbstract Authors: Stern N, Marcus Y Although nearly all arteries are surrounded by perivascular fat, its role in vascular function and disease is clearly understudied. At least one type of perivascular fat, epicardial adipose tissue, appears to be related to both weight and age and tends to express proatherogenic/proinflammatory products in subjects with cardiovascular disease. Perivascular fat may evolve from primordial cells in the adventitia or from circulating precursors migrating through the arterial wall. Once deposited periarterially, adipose tissue may release locally a large number of products, which potentially interact with the arterial wall. Additionally, the authors propose that perivascular fat, per se, may attract circulating monocytes through the release of chemokines such as mo... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564598 Sun, 01 Jan 2006 05:00:00 +0100 1564598 http://www.medworm.com/index.php?rid=1564597&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679831%26dopt%3DAbstract Authors: Leach C, Bach RG PMID: 17679831 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564597 Sun, 01 Jan 2006 05:00:00 +0100 1564597 http://www.medworm.com/index.php?rid=1564596&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679832%26dopt%3DAbstract Authors: Ferdinand KC Heart disease and stroke are the most life-threatening consequences of diabetes mellitus, with mortality rates up to two to four times higher for persons with diabetes vs. those without and accounting for up to 65% of deaths. The cardiometabolic syndrome is a potent indicator of future risk of type 2 diabetes and concomitant increased potential for cardiovascular morbidity and mortality. Pharmacologic treatment is usually necessary to improve blood pressure and lipids, thereby decreasing the risk of cardiovascular disease. The reduction of cardiovascular and renal risk with type 2 diabetes and elevated blood pressure are compelling indications for thiazide diuretics, blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and calcium ... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564596 Sun, 01 Jan 2006 05:00:00 +0100 1564596 http://www.medworm.com/index.php?rid=1564595&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17679833%26dopt%3DAbstract Authors: Leung PS, de Gasparo M The cardiometabolic syndrome consists of several major components: hypertension, hyperinsulinemia, hyperlipidemia, and hyperglycemia. Central to this syndrome are insulin resistance and generation of reactive oxygen species; these features are particularly prominent in patients with type 2 diabetes mellitus. In this context, large clinical trials have shown that blockade of the renin-angiotensin system (RAS) is protective against type 2 diabetes. In spite of these solid clinical data, the mechanistic pathways by which RAS blockade achieves these protective effects have yet to be resolved. A recently identified local pancreatic islet RAS has, however, been implicated in this regard. Furthermore, RAS blockade was recently shown to enhance islet blood flow,... Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564595 Sun, 01 Jan 2006 05:00:00 +0100 1564595 http://www.medworm.com/index.php?rid=1564565&cid=s_37284_7_f&fid=37284&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17694597%26dopt%3DAbstract Authors: Holland MR, Gibson AA, Peterson LR, Areces M, Schaffer JE, Perez JE, Miller JG PMID: 17694597 [PubMed - indexed for MEDLINE] (Source: Journal of the Cardiometabolic Syndrome) Journal of the Cardiometabolic Syndrome journals http://www.medworm.com/rss/comments.php?id=1564565 Sun, 01 Jan 2006 05:00:00 +0100 1564565