Journal of the European Academy of Dermatology and Venereology via MedWorm.com

Successful treatment of ulcerated haemangioma with propranolol

Journal of the European Academy of Dermatology and Venereology — Wed, 10 Mar 2010 00:00:00 +0100

Conclusions Propranolol may be the first-choice therapy for ulcerated haemangioma. (Source: Journal of the European Academy of Dermatology and Venereology)

Therapeutic and experimental therapeutic studies on acupuncture and itch: review of the literature

Journal of the European Academy of Dermatology and Venereology — Wed, 10 Mar 2010 00:00:00 +0100

This article summarizes the rational for the use of acupuncture in treatment of itch and reviews therapeutic and experimental therapeutic studies on acupuncture and itch. (Source: Journal of the European Academy of Dermatology and Venereology)

The epidemiology of adolescent acne in North East China

Journal of the European Academy of Dermatology and Venereology — Wed, 10 Mar 2010 00:00:00 +0100

Conclusion Adolescent acne includes a familial genetic predisposition. Additional environmental factors of psychological stress, skin oiliness and high caloric diets may also contribute to the onset of acne in Chinese adolescents. (Source: Journal of the European Academy of Dermatology and Venereology)

Complications of ambulatory major dermatological surgery in patients older than 85 years

Journal of the European Academy of Dermatology and Venereology — Wed, 10 Mar 2010 00:00:00 +0100

Conclusions No intra or post-surgical mortality or life-threatening local complications were detected. Most post-surgical local complications appeared after wide excisions and complex reconstruction techniques that prolonged the length of the surgery. (Source: Journal of the European Academy of Dermatology and Venereology)

The Four-color FISH probe in the diagnosis of melanocytic lesions

Journal of the European Academy of Dermatology and Venereology — Sat, 06 Mar 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Rising trends in incidence of cutaneous malignant melanoma and their future projections in Catalonia, Spain: increasing impact or future epidemic?

Journal of the European Academy of Dermatology and Venereology — Fri, 05 Mar 2010 00:00:00 +0100

Conclusion Improvements in preventive activities should be implemented to decrease incidence and mortality from this cancer. Monitoring stage-specific trends in CMM incidence can assess the impact of preventive strategies; for this reason more complete information on diagnostic features of CMM patients in the Spanish population-based cancer registries are necessary. (Source: Journal of the European Academy of Dermatology and Venereology)

Adjuvant triamcinolone acetonide injections in oro-pharyngeal pemphigus vulgaris

Journal of the European Academy of Dermatology and Venereology — Fri, 05 Mar 2010 00:00:00 +0100

Conclusion Perilesional/intralesional triamcinolone acetonide injections seems to represent a helpful clinical tool to successfully join CIST, in terms of shortening the time of complete clinical remission, reducing the total amount of corticosteroids and obtaining an acceptable compliance. (Source: Journal of the European Academy of Dermatology and Venereology)

Q-switched YAG laser vs. punch biopsy excision for iatrogenic radiation tattoo markers – a randomized controlled trial

Journal of the European Academy of Dermatology and Venereology — Fri, 05 Mar 2010 00:00:00 +0100

Conclusion Q-sw YAG laser and punch biopsy excision are effective to clear iatrogenic radiation tattoo markers, but patients preferred the laser treatment because of less pronounced adverse effects. (Source: Journal of the European Academy of Dermatology and Venereology)

Quality of life of patients with scabies

Journal of the European Academy of Dermatology and Venereology — Fri, 05 Mar 2010 00:00:00 +0100

Conclusion Scabies moderately affected the QoL of the patients. Sulphur could be considered as an effective treatment for patients with scabies. (Source: Journal of the European Academy of Dermatology and Venereology)

Onycotrychia?: subungual hair follicle as another cause of longitudinal melanonychia or pigmentation – Hair follicle as cause of melanonychia

Journal of the European Academy of Dermatology and Venereology — Fri, 05 Mar 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Aesthetic effects of topical photodynamic therapy

Journal of the European Academy of Dermatology and Venereology — Fri, 05 Mar 2010 00:00:00 +0100

This article reviews the available literature for photodynamic rejuvenation while discussing cosmetic effects, light sources, adverse effects and the mechanism of action. (Source: Journal of the European Academy of Dermatology and Venereology)

The use of topical bleaching agents among women: a cross-sectional study of knowledge, attitude and practices

Journal of the European Academy of Dermatology and Venereology — Fri, 05 Mar 2010 00:00:00 +0100

Conclusion A major proportion of our sample respondents have overused and/or misused bleaching agents. This was regardless of age, income, education or marital status. There is a need to educate women about the possible risks. (Source: Journal of the European Academy of Dermatology and Venereology)

Basal cell carcinoma – Epidemiology from 269 cases

Journal of the European Academy of Dermatology and Venereology — Fri, 05 Mar 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Bacterial colonization of chronic leg ulcers: current results compared with data 5 years ago in a specialized dermatology department

Journal of the European Academy of Dermatology and Venereology — Fri, 05 Mar 2010 00:00:00 +0100

Conclusion The results of our investigation demonstrate the current spectrum of the bacterial colonization in patients with chronic leg ulcers in a university dermatological wound centre in comparison to the last 5 years. In our institution we were able to demonstrate a shift of the detected bacterial species from gram-positive in direction to gram-negative germs. Beside the already known problems with MRSA, in future therapeutic strategies in patients with chronic leg ulcers the increasing amount of gram-negative bacteria and especially of P. aeruginosa should considered. (Source: Journal of the European Academy of Dermatology and Venereology)

Skin disorders in chronic psychiatric illness

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

Conclusions Many chronic psychiatric patients have skin problems. Clinical examination of the skin is important to discover these problems. Patients with diabetes mellitus are particularly at risk for skin infections. Because of their relationship with overweight and diabetes mellitus, atypical antipsychotics may be partly responsible for these serious complications. Only a few other relationships between psychiatric medication and specific skin problems were found. (Source: Journal of the European Academy of Dermatology and Venereology)

Efficacy and tolerability of pale sulfonated shale oil cream 4% in the treatment of mild to moderate atopic eczema in children: a multicentre, randomized vehicle-controlled trial

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

Conclusion Pale sulfonated shale oil cream 4% is capable to treat mild to moderate atopic eczema in children more efficaciously than vehicle and is well tolerated. PSSO thus represents a valuable addition to our therapeutic armamentarium. PSSO should be considered in particular when valid alternatives for topical glucocorticoids are sought for. (Source: Journal of the European Academy of Dermatology and Venereology)

Patch testing in allergic contact dermatitis: is it useful to perform the cosmetic series in addition to the European standard series?

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

Conclusion Patch testing with cosmetic series in addition to the European standard series increased the capability to detect the relevant allergen/allergens, particularly in patients with a suspicion of cosmetic allergy. However, it is not practical and cost-effective to test those patients routinely with all 45 allergens in the cosmetic series. As the European baseline series which includes methyldibromo glutaronitrile is now widely used as the guideline minimum set of allergens for routine diagnostic patch test investigations, we additionally recommend Euxyl K400 and isopropyl myristate as the candidates for patch testing. (Source: Journal of the European Academy of Dermatology and Venereology)

Paederus dermatitis in Egypt: a clinicopathological and ultrastructural study

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

Conclusions Clinical, histopathological and, for the first time, ultrastructural characteristics of paederus dermatitis are described. The pathological abnormalities of the upper epidermis are caused by the irritant effect of pederin toxin. The presence of apoptosis within the lower epidermis can be related to this toxin, a point that needs further research, hoping for its future implications in the management of hyperproliferative disorders. (Source: Journal of the European Academy of Dermatology and Venereology)

Different application techniques of pathergy testing among dermatologists

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Heterogeneous mutations of the ATP2C1 gene causing Hailey–Hailey disease in Hong Kong Chinese

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

Conclusion The six novel mutations provide additions to the HHD mutation database. No hot-spot mutation was found and high allelic heterogeneity was demonstrated in the Hong Kong Chinese patients. (Source: Journal of the European Academy of Dermatology and Venereology)

Cutaneous angiosarcoma: own experience over 13 years. Clinical features, disease course and immunohistochemical profile

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

Background Cutaneous angiosarcoma (AS) is a rare malignant tumour of endothelial origin with very poor prognosis, frequent recurrences and high metastatic potential. Clinical suspicion is often raised too late, but histological findings and immunohistochemical assays have proved to be very helpful in the diagnostic process.Patients and methods Over the last 13 years, nine patients with AS were found in our archives. Clinical features, evolution, treatment and outcome were analysed and all biopsy specimens were reviewed by a trained dermatopathologist, with subsequent immunohistochemical assessment.Results and conclusions Cutaneous AS was clinically diagnosed in 4 of 9 patients, while systemic lupus erythematosus was the most common misdiagnosis. Radiotherapy was the most prescribed treatme...

Porphyria cutanea tarda and beta-thalassaemia major: causal or casual?

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

A novel mutation in the cathepsin C gene in a Pakistani family with Papillon-Lefevre syndrome

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

Conclusion Our data further expand the spectrum of mutations in the CTSC gene underlying PLS. (Source: Journal of the European Academy of Dermatology and Venereology)

Pre-operative ultrasound with a 12–15 MHz linear probe reliably differentiates between melanoma thicker and thinner than 1 mm

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

Conclusion Ultrasound examination with a 12[ndash]15 MHz linear transducer can reliably differentiate primary melanoma > 1 mm from those [le] 1 mm. (Source: Journal of the European Academy of Dermatology and Venereology)

Association of adult mastocytosis with M541L in the transmembrane domain of KIT

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Psoriasis: an epidemiological evaluation of disease burden in 590 patients

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

In this study, 36.8% of patients with severe psoriasis reported a negative impact on their professional life vs. 19.6% for patients with mild psoriasis (P = 0.002). Time devoted to phototherapy was on average 33 h/year/patient and the application of emollients took 25 h/year/patient; 47.3% of patients had a feeling to clean the house more often, in correlation with the severity of the disease. Mean out-of-pocket expenses for the disease was estimated to be 543[euro]/year/patient. High impact of psoriasis on quality of life (DLQI >10), age (Source: Journal of the European Academy of Dermatology and Venereology)

Guidelines for the laboratory diagnosis of trichomoniasis in East European countries

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

The laboratory diagnosis of sexually transmitted infections in many Eastern European countries remains suboptimal. The main objective of the present evidence-based guidelines is to provide comprehensive information regarding the laboratory diagnosis of infections caused by Trichomonas vaginalis in East European countries. In particular, the present guidelines recommend: (i) to encourage examination of the wet mounts of vaginal exudates, instead of stained smears, at all clinical settings; (ii) nucleic acid amplification tests (NAATs) or culture could be employed if no trichomonads are detected on microscopic examination of the wet preparation and there is a strong indication of infection and (iii) the use of NAATs is encouraged in screening, using non-invasive specimens, or high volume tes...

Differential effects of a tertiary individual prevention programme for patients with occupational skin disease depending on diagnosis

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

Conclusion Professionals working in the field of OSD should not cease to assist AD patients in achieving optimal skin protection behaviour. Tertiary individual prevention measures may need to pay more attention to the needs of individuals with an occupationally relevant AD. This may contribute to their being able to remain active in the workforce. The alternative would entail regular sick leave, poorer quality of life and economic hardship for the AD patient. (Source: Journal of the European Academy of Dermatology and Venereology)

Analysis of the STS gene in 40 patients with recessive X-linked ichthyosis: a high frequency of partial deletions in a Spanish population

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

Conclusions Amplification of exons 1, 5 and 10 is reliable in screening RXLI in the population studied here. No correlation was found between phenotype and the extent of the deletions. (Source: Journal of the European Academy of Dermatology and Venereology)

Granulomatous variant of chronic pigmented purpuric dermatosis associated with hyperlipidaemia

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Psoriatic disease: concepts and implications

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Thyroid peroxidase antibodies in patients with telogen effluvium

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Aggravating factors for melasma: a prospective study in 197 Tunisian patients

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

Conclusion This study identifies a number of factors associated with the severity of melasma. Further epidemiological studies in this type of population, in particular, to investigate triggering factors, are justified by the aesthetic damage caused by melasma in dark-skinned patients, lack of efficacy of existing treatments, non-compliance with photoprotection recommendations and the challenge of treatment. (Source: Journal of the European Academy of Dermatology and Venereology)

Dermoscopic features of a collision tumour composed of a pigmented basal cell carcinoma and a melanoma

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Teledermatology integrated in the Dutch national healthcare system

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

A teledermatology practice model for a national healthcare system: proposal and recommendations

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Epidemiology of vitiligo, associated autoimmune diseases and audiological abnormalities: Ankara study of 80 patients in Turkey

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

Conclusion Our study demonstrates that vitiligo is a part of systemic autoimmune process. Audiological examination should be performed in all patients for auditory problems which are commonly presented as hypoacusis. (Source: Journal of the European Academy of Dermatology and Venereology)

The high rate of familial lichen sclerosus suggests a genetic contribution: an observational cohort study

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

Conclusion Our data from a large cohort of patients with LS provide evidence of an increased risk for family members to develop LS. This indicates a likely genetic component in the aetiology of LS. (Source: Journal of the European Academy of Dermatology and Venereology)

Role of Synchrotron infra red microspectroscopy in studying epidermotropism of cutaneous T-cell lymphoma

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

Conclusions The biochemical analysis of protein, RNA and DNA with Synchrotron IR microspectroscopy is a promising tool for studying epidermotropism in cutaneous T-cell lymphoma. (Source: Journal of the European Academy of Dermatology and Venereology)

Pemphigus, analysis of 155 patients

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

Conclusions The course and outcome of pemphigus are worse in patients who are young at diagnosis (< 40 years) or of Sephardic Jewish origin. Mucosal involvement at diagnosis and poor response to treatment also predict poor outcome. The mortality rate of pemphigus is apparently lower than reported in the literature, perhaps because of the contemporary use of adjuvant immunomodulatory therapeutic agents. (Source: Journal of the European Academy of Dermatology and Venereology)

Subcutaneous zygomycosis: report of 10 cases from two institutions in North India

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

Conclusion Awareness and early recognition will prevent disfigurement produced by advanced disease, misdiagnosis and unnecessary surgical intervention. (Source: Journal of the European Academy of Dermatology and Venereology)

A case of multiple benign fibrous histiocytoma with indeterminate cells and eosinophils

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Intralesional immunotherapy of common warts: successful treatment with mumps, measles and rubella vaccine

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

Conclusions Intralesional immunotherapy by MMR vaccine is a promising effective and safe treatment modality for common warts, particularly the multiple ones. (Source: Journal of the European Academy of Dermatology and Venereology)

Prevalence and prognostic value of cutaneous manifestations in patients with myelodysplastic syndrome

Journal of the European Academy of Dermatology and Venereology — Thu, 25 Feb 2010 00:00:00 +0100

Conclusion The prevalence of skin lesions, mostly neutrophilic dermatosis and specific lesions, is relatively high in patients with MDS. There is a trend for a higher risk of transformation into acute myeloid leukaemia in patients with skin lesions. (Source: Journal of the European Academy of Dermatology and Venereology)

Total nail ablation for onychodystrophy with optimized gauze–phenol application

Journal of the European Academy of Dermatology and Venereology — Wed, 17 Feb 2010 00:00:00 +0100

Conclusion Phenol-based total nail ablation with specific gauze application is safe, inexpensive and has a high rate of patient satisfaction. (Source: Journal of the European Academy of Dermatology and Venereology)

Idiopathic guttate hypomelanosis-like lesions in patients with mycosis fungoides: a new adverse effect of phototherapy

Journal of the European Academy of Dermatology and Venereology — Wed, 17 Feb 2010 00:00:00 +0100

Conclusions Phototherapy may induce an eruption bearing similar clinical and histopathological features to IGH. The eruption is rare, appears to emerge only after prolonged therapy and seems to be reversible upon discontinuation of phototherapy. IGH-like eruption should be added to the list of side-effects of phototherapy. (Source: Journal of the European Academy of Dermatology and Venereology)

Ungual seborrheic keratosis

Journal of the European Academy of Dermatology and Venereology — Wed, 17 Feb 2010 00:00:00 +0100

Conclusion To our knowledge, this is the first report of a typical, histologically documented seborrheic keratosis of the nail bed. Therefore, this condition should be added to the differential diagnosis of acquired longitudinal leukoxanthonychia. However, surgical treatment remains necessary to rule out other causes, including squamous cell carcinoma. (Source: Journal of the European Academy of Dermatology and Venereology)

Questionnaire-based survey of the treatment of patients with psoriasis and hepatitis C in Japan

Journal of the European Academy of Dermatology and Venereology — Wed, 17 Feb 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Magnetic resonance imaging of the skin

Journal of the European Academy of Dermatology and Venereology — Wed, 17 Feb 2010 00:00:00 +0100

We present basic principles of MRI, as well as several interesting applications in the field of dermatology, and discuss the advantages and limitations of this method. (Source: Journal of the European Academy of Dermatology and Venereology)

Urinary 8-OHdG level in psoriasis and atopic dermatitis

Journal of the European Academy of Dermatology and Venereology — Wed, 17 Feb 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

A missense mutation in KRT14 causing a dermatopathia pigmentosa reticularis/Naegeli–Franceschetti–Jadassohn phenotype

Journal of the European Academy of Dermatology and Venereology — Wed, 17 Feb 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Efficacy and safety of 1064-nm Q-switched Nd:YAG laser with low fluence for keloids and hypertrophic scars

Journal of the European Academy of Dermatology and Venereology — Thu, 11 Feb 2010 00:00:00 +0100

Conclusion Our results demonstrate that QS Nd:YAG laser with low fluence may be used for the treatment of keloids and hypertrophic scars. (Source: Journal of the European Academy of Dermatology and Venereology)

Twice-weekly treatment with tacrolimus 0.03% ointment in children with atopic dermatitis: clinical efficacy and economic impact over 12 months

Journal of the European Academy of Dermatology and Venereology — Wed, 10 Feb 2010 00:00:00 +0100

Conclusions In children with AD, twice-weekly treatment with tacrolimus 0.03% ointment reduces the number of flares and prolongs time spent free from flares with no additional cost in children with moderate AD, and may be cost-saving in those with severe AD. (Source: Journal of the European Academy of Dermatology and Venereology)

Atypical fibroxanthoma: a series of 25 cases

Journal of the European Academy of Dermatology and Venereology — Wed, 10 Feb 2010 00:00:00 +0100

Conclusions Micrographic controlled surgery with wide 2 cm safety margins is the treatment of choice. A regular follow-up for the next 5 years is recommended. (Source: Journal of the European Academy of Dermatology and Venereology)

Sentinel lymph node biopsy in melanoma patients

Journal of the European Academy of Dermatology and Venereology — Wed, 10 Feb 2010 00:00:00 +0100

Appropriate surgical management of regional lymph nodes is critical in patients with cutaneous melanoma. The use of intraoperative lymphatic mapping and sentinel lymph node biopsy (SLNB) has increased significantly in the past decade. SLNB is performed as minimally invasive procedure that provides accurate staging of melanoma patients with no clinically detectable nodal disease. In many melanoma units across the world, it became the standard for detection of occult regional node metastasis in patients with intermediate-thickness primary melanoma. Use of SLNB in patients with thin melanomas is still under evaluation. Although SLNB has been established as staging procedure in melanoma patients, its therapeutic role is still not clear. Large-scale ongoing randomized trials should elucidate wh...

Efficacy of sulfasalazine in the treatment of generalized lichen planus: randomized double-blinded clinical trial on 52 patients

Journal of the European Academy of Dermatology and Venereology — Wed, 10 Feb 2010 00:00:00 +0100

Conclusions Statistically, sulfasalazine was more effective than placebo in reducing cutaneous lesions and improving pruritus after 6 weeks of treatment. According to our study, sulfasalazine is a relatively safe and effective treatment option and may be an alternative therapy for the treatment of generalized lichen planus. (Source: Journal of the European Academy of Dermatology and Venereology)

HPA-suppressive effects of aqueous clobetasol propionate in the treatment of patients with oral lichen planus

Journal of the European Academy of Dermatology and Venereology — Wed, 10 Feb 2010 00:00:00 +0100

Conclusions Hypothalamus[ndash]pituitary[ndash]adrenal inhibition is substantial during initial treatment with aqueous CP three times daily. (Source: Journal of the European Academy of Dermatology and Venereology)

Results of a public awareness campaign in Morocco regarding the sun's deleterious effects

Journal of the European Academy of Dermatology and Venereology — Mon, 08 Feb 2010 00:00:00 +0100

Conclusion Our study reports the results of the first public awareness campaign on the sun's deleterious effects on the Moroccan population, inclusive and relevant to all ages. Awareness of the sun's radiation-related risks in a country as sunny as ours is low, whereas different measures of photoprotection are rather well known. Messages adapted to the characteristics of our population are a necessity. (Source: Journal of the European Academy of Dermatology and Venereology)

A novel two-step kit for topical treatment of tinea pedis – an open study

Journal of the European Academy of Dermatology and Venereology — Tue, 02 Feb 2010 00:00:00 +0100

Conclusions This novel treatment was found to be effective, well tolerated and safe in the treatment of moderate and severe tinea pedis during the active and the preventive stages. (Source: Journal of the European Academy of Dermatology and Venereology)

Relationships between obesity and the clinical severity of psoriasis in Taiwan

Journal of the European Academy of Dermatology and Venereology — Tue, 02 Feb 2010 00:00:00 +0100

Conclusions In psoriasis patients, obesity is associated with a more severe disease, especially in men. Bodyweight control may be important for the management of psoriasis. (Source: Journal of the European Academy of Dermatology and Venereology)

Fibrosing alopecia in a pattern distribution

Journal of the European Academy of Dermatology and Venereology — Tue, 02 Feb 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Arteriolosclerotic ulcer of Martorell

Journal of the European Academy of Dermatology and Venereology — Fri, 22 Jan 2010 00:00:00 +0100

In 1945, Martorell described ischaemic leg ulcers in patients with hypertension. He suggested that the ischaemic necrosis was secondary to a hypertensive arteriolar disease and referred to them as 'hypertensive ischaemic ulcers'. In recent years, the specific entity of these ulcers has been questioned. Others claim they have a much higher incidence, but presume the diagnosis is frequently missed. Almost 900 cases of Martorell's ulcers have been reported in literature since the first description. A systematic review and comprehensive search of literature (evidence-based) was needed to characterize this type of ulcer. Based on aetiology and histopathology, it seems to be justified to maintain the name 'arteriolosclerotic ulcer of Martorell'. We conclude that the arteriolosclerotic ulcer of M...

Reply to Alberto Giannetti, MD, PhD commentary regarding the European S3-Guidelines on the systemic treatment of Psoriasis

Journal of the European Academy of Dermatology and Venereology — Fri, 15 Jan 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Polidocanol foam sclerotherapy is a new and effective treatment for post-operative lymphorrhea and lymphocele

Journal of the European Academy of Dermatology and Venereology — Tue, 12 Jan 2010 00:00:00 +0100

Conclusion Polidocanol foam sclerotherapy is an effective and well-tolerated new treatment for patients with post-operative lymphoceles. (Source: Journal of the European Academy of Dermatology and Venereology)

Commentary on the European S3-Guidelines on the systemic treatment of Psoriasis

Journal of the European Academy of Dermatology and Venereology — Mon, 11 Jan 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Late recurrence (10 years or more) of malignant melanoma in south-east Germany (Saxony) A single-centre analysis of 1881 patients with a follow-up of 10 years or more

Journal of the European Academy of Dermatology and Venereology — Mon, 11 Jan 2010 00:00:00 +0100

Conclusions Late recurrence is a clinical sign of melanoma dormancy. We conclude that late recurrences argue for a lifelong follow-up of melanoma patients. (Source: Journal of the European Academy of Dermatology and Venereology)

What is the most effective treatment of cheilitis granulomatosa in Melkersson–Rosenthal syndrome?

Journal of the European Academy of Dermatology and Venereology — Mon, 11 Jan 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Well being, psychopathology and coping strategies in psoriasis compared with atopic dermatitis: a controlled study

Journal of the European Academy of Dermatology and Venereology — Mon, 11 Jan 2010 00:00:00 +0100

Conclusions We propose two explanations, derived from the psychological and the psycho-neuro-immunological domains. First, greater mental distress in psoriasis is because of the greater stigma it bears compared with AD. Alternatively, we hypothesize that the psoriatic inflammatory process may possibly have a direct central nervous system effect. (Source: Journal of the European Academy of Dermatology and Venereology)

Androgenic pattern presentation of scarring and inflammatory alopecia

Journal of the European Academy of Dermatology and Venereology — Thu, 07 Jan 2010 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

The east–west advancement flap (horizontal advancement flap) to repair a defect on the nose ala

Journal of the European Academy of Dermatology and Venereology — Wed, 06 Jan 2010 00:00:00 +0100

Conclusion In selected patients with small-to-medium-size defects of the nasal ala, the horizontal advancement flap is a simple, reliable and aesthetic reconstruction option. (Source: Journal of the European Academy of Dermatology and Venereology)

A multilocus candidate approach identifies ACE and HIF1A as susceptibility genes for cellulite

Journal of the European Academy of Dermatology and Venereology — Wed, 06 Jan 2010 00:00:00 +0100

Conclusions This study, which demonstrates an independent role of ACE and HIF1A in predisposing to cellulite, may provide novel information on the pathophysiology of this common cosmetic problem, and offer a topic for research for novel beautification interventions. (Source: Journal of the European Academy of Dermatology and Venereology)

Dermoscopic rainbow pattern in basal cell carcinoma – reply

Journal of the European Academy of Dermatology and Venereology — Sat, 19 Dec 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Photodynamic therapy with 5-aminolevulinic acid in actinic cheilitis: an 18-month clinical and histological follow-up

Journal of the European Academy of Dermatology and Venereology — Fri, 18 Dec 2009 00:00:00 +0100

Conclusion PDT represents a moderately effective treatment modality in AC. Optimization of treatment procedure and protocols is still needed for higher response rates to be achieved. Moreover, the high treatment cost should be given consideration. Further long-term follow-up studies are needed for assessment of clinical and histological very late recurrences that could be expected after PDT. (Source: Journal of the European Academy of Dermatology and Venereology)

Non-ablative 1550-nm erbium-glass and ablative 10 600-nm carbon dioxide fractional lasers for acne scars: a randomized split-face study with blinded response evaluation

Journal of the European Academy of Dermatology and Venereology — Thu, 17 Dec 2009 00:00:00 +0100

Conclusion We demonstrated the efficacy and safety of single-session acne scar treatment using FPS and CO2 FS in East Asian patients. We believe that our study could be used as an essential reference when choosing laser modalities for scar treatment. (Source: Journal of the European Academy of Dermatology and Venereology)

Tattoo removal by non-professionals – medical and forensic considerations

Journal of the European Academy of Dermatology and Venereology — Thu, 17 Dec 2009 00:00:00 +0100

The objective of this study is to assess potential risks and pitfalls of laser tattoo removal when performed by medical laymen. The methods followed are systematic and evidence-based review of the literature. Four major problem areas were identified: rare but potentially severe allergic or toxic effects of decomposition products of the tattoo pigments; bodily harm caused by out-of-specification usage of the laser devices; malignant disease that is obscured within the area of a tattoo and requires meticulous dermatological diagnosis; and insufficient pre-operative consultation of patients about the risks, side effects and realistic expectations on the therapeutic outcome. We came to a conclusion that tattoo laser removal by medical laymen is unacceptable from the point of view of patient sa...

A novel mutation in the FERMT1 gene in a Spanish family with Kindler's syndrome

Journal of the European Academy of Dermatology and Venereology — Thu, 17 Dec 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Acquired erythroderma in adults: a clinical and prognostic study

Journal of the European Academy of Dermatology and Venereology — Thu, 17 Dec 2009 00:00:00 +0100

Conclusions Our study illustrates the severity of erythroderma. It alters heavily the quality of life of patients which is initially altered by the pre-existent dermatosis. It may be life threatening as mortality rate is high. (Source: Journal of the European Academy of Dermatology and Venereology)

Efficacy of amorolfine nail lacquer for the prophylaxis of onychomycosis over 3 years

Journal of the European Academy of Dermatology and Venereology — Thu, 17 Dec 2009 00:00:00 +0100

Conclusion These results suggest that amorolfine nail lacquer may be effective and is safe for use as a prophylactic treatment for the recurrence of onychomycosis. (Source: Journal of the European Academy of Dermatology and Venereology)

Dermoscopic rainbow pattern in basal cell carcinoma

Journal of the European Academy of Dermatology and Venereology — Thu, 17 Dec 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Oral verrucous carcinoma treated with carbon dioxide laser

Journal of the European Academy of Dermatology and Venereology — Thu, 17 Dec 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Latanoprost in the treatment of eyelash alopecia in alopecia areata universalis

Journal of the European Academy of Dermatology and Venereology — Thu, 17 Dec 2009 00:00:00 +0100

Conclusions Latanoprost may be an effective drug in the treatment of eyelash AA because it induces acceptable responses (total and moderate) in 45% of the patients. A formal, blinded prospective unilateral controlled study will permit further understanding about this promising therapeutic agent for eyelash AA. (Source: Journal of the European Academy of Dermatology and Venereology)

Porphyria cutanea tarda induced by olmesartan

Journal of the European Academy of Dermatology and Venereology — Wed, 16 Dec 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Methotrexate/narrowband UVB phototherapy combination vs. narrowband UVB phototherapy in the treatment of chronic plaque-type psoriasis – a randomized single-blinded placebo-controlled study

Journal of the European Academy of Dermatology and Venereology — Tue, 15 Dec 2009 00:00:00 +0100

Conclusion Combination of methotrexate and NBUVB phototherapy provides more rapid clinical improvement compared with NBUVB monotherapy in the treatment for chronic plaque-type psoriasis. (Source: Journal of the European Academy of Dermatology and Venereology)

Quality of life in patients with lepromatous leprosy in China

Journal of the European Academy of Dermatology and Venereology — Tue, 15 Dec 2009 00:00:00 +0100

Conclusions This is the first exclusive study to attempt to measure the impact of lepromatous leprosy on QoL. Lepromatous leprosy has a severe impact on QoL. (Source: Journal of the European Academy of Dermatology and Venereology)

Albright hereditary osteodystrophy: report of a particular clinical phenotype caused by a novel GNAS mutation

Journal of the European Academy of Dermatology and Venereology — Tue, 15 Dec 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Melasma in men: a clinical, aetiological and histological study

Journal of the European Academy of Dermatology and Venereology — Tue, 15 Dec 2009 00:00:00 +0100

Conclusions Melasma is frequently observed in Indian men. The main causative factors among the male patients appeared to be sun-exposure and family history. Melasma in men is definitely less common than in women, but shares the same clinicohistopathological characteristics as in women. (Source: Journal of the European Academy of Dermatology and Venereology)

Professional risk for skin cancer development in male mountain guides – a cross-sectional study

Journal of the European Academy of Dermatology and Venereology — Tue, 15 Dec 2009 00:00:00 +0100

Conclusion The present study demonstrates an association between high occupational ultraviolet-exposure and an increased prevalence of precancerous skin lesions and skin cancer. MG may be considered as an example for other outdoor professionals. Skin cancer of outdoor workers is likely to be an occupational disease. Primary and secondary prevention should be enforced. (Source: Journal of the European Academy of Dermatology and Venereology)

Candida balanitis: risk factors

Journal of the European Academy of Dermatology and Venereology — Sat, 12 Dec 2009 00:00:00 +0100

Conclusions This study highlights the impact of factors other than sexual behaviours upon the epidemiology of this infection. For both candida colonization and infection, age was an important risk factor. Diabetes mellitus was an independent risk factor for candida balanitis. More than ten colonies recovered from culture are associated with clinical signs and symptoms. (Source: Journal of the European Academy of Dermatology and Venereology)

Intense pulsed light vs. pulsed-dye laser in the treatment of facial acne: a randomized split-face trial

Journal of the European Academy of Dermatology and Venereology — Fri, 11 Dec 2009 00:00:00 +0100

Conclusion Both PDL and IPL were found to treat acne effectively, but PDL showed a more sustained effect. TGF-[beta] might play a key role in the resolution of inflammatory acne lesions. (Source: Journal of the European Academy of Dermatology and Venereology)

C-reactive protein and leucocyte activation in psoriasis vulgaris according to severity and therapy

Journal of the European Academy of Dermatology and Venereology — Fri, 11 Dec 2009 00:00:00 +0100

Conclusion We propose CRP as a useful marker of psoriasis severity that could be used to monitor psoriasis and its treatment, and, together with PASI and elastase, could also be used as a global index of severity. (Source: Journal of the European Academy of Dermatology and Venereology)

Evaluation of JPEG and JPEG2000 compression algorithms for dermatological images

Journal of the European Academy of Dermatology and Venereology — Fri, 11 Dec 2009 00:00:00 +0100

Conclusion When JPEG and JPEG2000 algorithms were compared, it was observed that JPEG2000 algorithm was more successful than JPEG for all compression rates. However, loss of image quality is recognizable in some of images in all compression rates. (Source: Journal of the European Academy of Dermatology and Venereology)

Dermoscopic features of Bowen's disease in Asians

Journal of the European Academy of Dermatology and Venereology — Thu, 10 Dec 2009 00:00:00 +0100

Conclusions Vascular structures, especially glomerular vessels plus a scaly surface, were common dermoscopic findings of BD in Asians. In addition, existence of dermoscopic vascular structures after treatment appears to be associated with residual disease. (Source: Journal of the European Academy of Dermatology and Venereology)

Sexually transmitted infections and related sociodemographic factors in Lisbon's major Venereology Clinic: a descriptive study of the first 4 months of 2007

Journal of the European Academy of Dermatology and Venereology — Thu, 10 Dec 2009 00:00:00 +0100

Conclusions Despite its limitations, our study allows some insight into the relationships between sociodemographic factors and STI in a selected population attending Lisbon's major Venereology Clinic. The results were similar to those of other European studies and to recent trends in STI, but differ in the association between C. trachomatis infection and non-Caucasian women, which is similar to cities with significant African minorities. Attention should be given to the associations found between men who have sex with men and STI such as gonorrhoea, syphilis and HIV, as these associations can lead to serious difficulties in the control of HIV infection in Portugal. (Source: Journal of the European Academy of Dermatology and Venereology)

Authors' willingness for second-opinion teledermatology in difficult-to-manage cases: 'an online survey'

Journal of the European Academy of Dermatology and Venereology — Thu, 10 Dec 2009 00:00:00 +0100

Conclusion A dermatologist obtains literature, answered queries and constructive suggestions with additional informative material and pools second-opinions from the authors using their e-mail to deliver quality health care. AST is an alternative to online discussion group for second-opinion teledermatology practice in difficult-to-manage cases. Uniform international laws are to be framed to facilitate telemedicine care for a difficult-to-manage case. (Source: Journal of the European Academy of Dermatology and Venereology)

Psoriasis is independently associated with psychiatric morbidity and adverse cardiovascular risk factors, but not with cardiovascular events in a population-based sample

Journal of the European Academy of Dermatology and Venereology — Thu, 10 Dec 2009 00:00:00 +0100

Conclusion Psoriasis appears to be independently associated with major psychiatric disorders and with cardiovascular risk factors, but not with cardiovascular events. (Source: Journal of the European Academy of Dermatology and Venereology)

Ineffectiveness of sun awareness posters in dermatology clinics

Journal of the European Academy of Dermatology and Venereology — Tue, 08 Dec 2009 00:00:00 +0100

Conclusion Organizations that produce and disseminate posters should consider beyond focus groups when they design their posters and should consider field testing their products to ensure that they are reaching the targeted audience and are having the expected beneficial effect, otherwise their posters are simply decorative. (Source: Journal of the European Academy of Dermatology and Venereology)

Who uses sunbeds? A systematic literature review of risk groups in developed countries

Journal of the European Academy of Dermatology and Venereology — Tue, 08 Dec 2009 00:00:00 +0100

Skin cancer is caused by ultraviolet radiation (UVR). Indoor tanning is a totally avoidable risk behaviour. This review addresses the specific characteristics of sunbed users and the differences in motivation and risk perception compared with non-users. This review is based solely on empirical original articles. Based on literature searches with widely used reference databases ('PubMed', 'OVID', 'Social Citation Index', 'ERIC [ndash] Educational Resources Information Center', 'Web of Science' and the 'International Bibliography of the Social Sciences'), we included studies from developed nations with a publication date between 1 January 2000 and 12 August 2008. All studies were selected, classified and coded simultaneously by both authors on a blinded basis. All searches were performed on ...

A novel deletion mutation in P2RY5/LPA6 gene cause autosomal recessive woolly hair with hypotrichosis

Journal of the European Academy of Dermatology and Venereology — Tue, 08 Dec 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Caveolae in Fabry telangiectagia

Journal of the European Academy of Dermatology and Venereology — Tue, 08 Dec 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Microbiological analysis of epidermal growth factor receptor inhibitor therapy-associated paronychia

Journal of the European Academy of Dermatology and Venereology — Tue, 08 Dec 2009 00:00:00 +0100

Conclusion Empirical oral antibiotic treatment may be performed with oral cephalosporines, ciprofloxacin, levofloxacin or moxifloxacin, as these antimicrobials have high in vitro activity against the majority of the isolated microorganisms and reach high concentrations in the relevant tissue. (Source: Journal of the European Academy of Dermatology and Venereology)

Cutaneous sarcoidosis: updates in the pathogenesis

Journal of the European Academy of Dermatology and Venereology — Tue, 08 Dec 2009 00:00:00 +0100

Sarcoidosis is a multiorgan granulomatous disease in which the skin is one of the frequently involved target organs. Cutaneous involvement occurs in a third of patients with sarcoidosis and has protean manifestations. More than a century has passed since the initial description of sarcoidosis, but its cause continues to be an enigma. Recent studies have introduced several new insights into the pathogenesis of this disease. The aim of this literature review was to provide a comprehensive overview on the current updates in the pathogenesis of sarcoidosis. This review has revealed that several genetic polymorphisms are associated with an increased risk of developing sarcoidosis, suggesting that genetic susceptibility to sarcoidosis is probably polygenic. Environmental factors may also modify ...

Response to Professor Derek R. Smith – JEADV-2009-1033 a new view on psoriasis research efforts

Journal of the European Academy of Dermatology and Venereology — Tue, 08 Dec 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Genital verrucous carcinoma is associated with lichen sclerosus: a retrospective study and review of the literature

Journal of the European Academy of Dermatology and Venereology — Tue, 08 Dec 2009 00:00:00 +0100

Conclusions Our study and review of the literature demonstrate that vulval verrucous carcinoma is strongly associated with LS. In contrast, perianal verrucous carcinoma is not associated with LS. When genital verrucous carcinoma is diagnosed, it is important to consider LS as a potential concomitant diagnosis and offer appropriate treatments and close follow-up to detect recurrence of verrucous carcinoma. (Source: Journal of the European Academy of Dermatology and Venereology)

A new view on psoriasis research efforts

Journal of the European Academy of Dermatology and Venereology — Tue, 01 Dec 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Treatment of refractory adult-onset pityriasis rubra pilaris with TNF-alpha antagonists: a case series

Journal of the European Academy of Dermatology and Venereology — Mon, 30 Nov 2009 00:00:00 +0100

Conclusions Both TNF-alpha antagonists proved successful for the treatment of refractory, adult-onset PRP, yielding complete and persistent clinical responses in type-I PRP. Infliximab was associated with a more rapid onset of action, while treatment duration was comparable with etanercept. PRP type II warranted long-term therapy and showed relapse after drug discontinuation. (Source: Journal of the European Academy of Dermatology and Venereology)

Efficacy of capsaicin in the treatment of acne in one case: new pathophysiological perspectives

Journal of the European Academy of Dermatology and Venereology — Mon, 30 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Soy sauce allergy

Journal of the European Academy of Dermatology and Venereology — Tue, 24 Nov 2009 00:00:00 +0100

Conclusions In this study, we confirmed by prick test, four cases of soy sauce allergy, which was caused by some products during brewing. When patients with inflammations around mouth, after a meal containing or using soy sauce, are examined, it should be considered whether dermatitis or cellulites were developed by allergic reaction or by histamine poisoning. (Source: Journal of the European Academy of Dermatology and Venereology)

A study of serial vertical sectioning of scalp biopsies to increase the histological diagnostic yield in alopecias

Journal of the European Academy of Dermatology and Venereology — Mon, 23 Nov 2009 00:00:00 +0100

Conclusions Serial vertical sectioning of scalp alopecias increases the histological diagnostic yield, substantially. (Source: Journal of the European Academy of Dermatology and Venereology)

Oxidative stress in acne vulgaris

Journal of the European Academy of Dermatology and Venereology — Mon, 23 Nov 2009 00:00:00 +0100

Conclusion These results suggest that oxidative damage may play a role in the pathogenesis of acne; therefore, significant alterations may occur in the antioxidant defence system. (Source: Journal of the European Academy of Dermatology and Venereology)

Congenital erosive and vesicular dermatosis healing with reticulated supple scarring with extensive facial involvement

Journal of the European Academy of Dermatology and Venereology — Mon, 23 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Efficacy of intralesional methotrexate in specific cutaneous involvement of B-cell chronic lymphocytic leukaemia

Journal of the European Academy of Dermatology and Venereology — Mon, 23 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Is the Dermatology Life Quality Index really time-sensitive?

Journal of the European Academy of Dermatology and Venereology — Fri, 20 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Prognostic factors for cure following treatment of onychomycosis

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions Several host-related factors at baseline and positive culture at 24 weeks had negative effects on cure of onychomycosis 72 weeks after treatment was initiated. This finding merits a large study on prognostic outcome factors in onychomycosis. (Source: Journal of the European Academy of Dermatology and Venereology)

Tissue and blood superoxide dismutase activity and malondialdehyde level in leprosy

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion Oxidative stress was observed in both tissues and blood of MB patients and in tissues of PB patients, denoting its crucial involvement in the pathogenesis of leprosy. This can constitute an important tool in prognosis, treatment and control of leprosy. (Source: Journal of the European Academy of Dermatology and Venereology)

Multiple trichoepitheliomas – a novel mutation in the CYLD gene

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions The predominating tumours define the classification of these three entities. Nevertheless, studies suggest that can simply represent phenotypic variations of the same disease spectrum, sharing common genetic mutations. (Source: Journal of the European Academy of Dermatology and Venereology)

Efficacy of narrowband UVB vs. PUVA in patients with early-stage mycosis fungoides

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions Our results confirm that phototherapy is a safe, effective and well-tolerated, first-line therapy in patients with early-stage cutaneous T-cell lymphoma, with prolonged disease-free remissions being achieved. It suggests that narrowband UVB is at least as effective as PUVA for treatment of early-stage MF. (Source: Journal of the European Academy of Dermatology and Venereology)

Sarcoidosis and sarcoid-like pathologies of the skin: result of a common pathological (immunodeficiency) process? – Authors' reply to the comment of Dr Luis Ignacio Gonzalez-Granado

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

The impact of obesity on skin disease and epidermal permeability barrier status

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion Specific dermatoses as skin tags, striae distensae and plantar hyperkeratosis, could be considered as a cutaneous stigma of severe obesity. The low permeability of the skin to evaporative water loss is observed in obese subjects compared with normal weight control. Although the physiological mechanisms are still unknown, this finding has not been previously described and we believe that this may constitute a new field in the research on obesity. (Source: Journal of the European Academy of Dermatology and Venereology)

No association between nickel allergy and reporting cosmetic dermatitis from mascara or eye shadow: a cross-sectional general population study

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusion Overall, no association between having nickel allergy and reporting cosmetic dermatitis from mascara or eye shadow use was found in the general population. This does not exclude a causal relationship in selected cases. (Source: Journal of the European Academy of Dermatology and Venereology)

Cetuximab-induced cutaneous toxicity

Journal of the European Academy of Dermatology and Venereology — Thu, 19 Nov 2009 00:00:00 +0100

Conclusions The most frequent cutaneous side effect reported in this series was acneiform eruption. The authors observed that all women with acneiform rash had only limited facial involvement, whereas all but one man experienced more widespread lesions of the face, the back and the chest. We found no association between the extent and severity of cutaneous eruptions (grade 1 vs. grade 2) and patients' response to therapy. (Source: Journal of the European Academy of Dermatology and Venereology)

Skin fragility and blistering with imatinib mesylate

Journal of the European Academy of Dermatology and Venereology — Wed, 18 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Notalgia paresthesica successfully treated with narrow-band UVB: report of five cases

Journal of the European Academy of Dermatology and Venereology — Wed, 18 Nov 2009 00:00:00 +0100

Conclusion Given the benefits achieved, we stress the interest of UVB narrow-band as a safe and well tolerated alternative treatment for notalgia paresthetica. (Source: Journal of the European Academy of Dermatology and Venereology)

Porokeratotic eccrine ostial and dermal duct naevus: report of 10 cases

Journal of the European Academy of Dermatology and Venereology — Wed, 18 Nov 2009 00:00:00 +0100

Conclusions PEODDN is a rare disorder that usually appears at birth or early childhood. It has a linear distribution following the Blaschko lines. To our knowledge this is the largest series reported in English literature and we also describe the first family case. (Source: Journal of the European Academy of Dermatology and Venereology)

Humoral deficiencies as an underlying cause of sarcoidosis of the skin

Journal of the European Academy of Dermatology and Venereology — Wed, 18 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Drug-induced angioedema without urticaria: prevalence and clinical features

Journal of the European Academy of Dermatology and Venereology — Wed, 18 Nov 2009 00:00:00 +0100

Conclusions Non-steroidal anti-inflammatory drugs and antibiotics were the most common drugs causing angioedema without urticaria. The duration of onset ranged from minutes to days. After stopping the suspected drugs, symptoms disappeared within 2[ndash]5 days in most patients. (Source: Journal of the European Academy of Dermatology and Venereology)

Plasmacytoid dendritic cell neoplasm treated successfully with rituximab

Journal of the European Academy of Dermatology and Venereology — Tue, 17 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Quality of life and health-related utility analysis of adults with moderate and severe atopic dermatitis treated with tacrolimus ointment vs. topical corticosteroids

Journal of the European Academy of Dermatology and Venereology — Tue, 17 Nov 2009 00:00:00 +0100

Conclusion Treatment with 0.1% tacrolimus ointment rather than a standard topical corticosteroid ointment regimen was associated with clinically significant, incremental improvement in QoL, sustained over a 6-month period. A within-trial cost-utility estimate based on study medication cost alone suggests that tacrolimus ointment is highly cost-effective given existing willingness-to-pay thresholds. (Source: Journal of the European Academy of Dermatology and Venereology)

Angiokeratoma regression in a Fabry disease after treatment with agalsidase-β: clinical effectiveness marker?

Journal of the European Academy of Dermatology and Venereology — Tue, 17 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Microalbuminuria as an early marker of renal involvement in Behcet's disease: it is associated with neurological involvement and duration of the disease

Journal of the European Academy of Dermatology and Venereology — Tue, 17 Nov 2009 00:00:00 +0100

Background Despite its nature as a systemic vasculitis, renal involvement is known to occur infrequently in Behçet's Disease (BD).Objectives Our aim was to investigate proteinuria, microhematuria and microalbuminuria in 24-h urine and evaluate subclinical or symptomatic renal involvement in BD patients.Methods Two hundred and eleven patients who fulfilled the International Behçet's Disease criteria were included in the study. After urine analysis, five of 12 patients who were found to have proteinuria underwent renal biopsy, while 199 patients without proteinuria were investigated for microalbuminuria (MA).Results A total of 34 (16.1%) patients were found to have renal involvement including 22 (11.1%) with MA and 12 with proteinuria (5.6%). Renal biopsies resulted as focal glomeruloscler...

Voluntary work in the early diagnosis of melanoma

Journal of the European Academy of Dermatology and Venereology — Tue, 10 Nov 2009 00:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Self-learning digital modules in Dermatology: a pilot study

Journal of the European Academy of Dermatology and Venereology — Tue, 10 Nov 2009 00:00:00 +0100

Conclusion To conclude, we would like to suggest that the use of a 'play area' like concept coupled with an interactive information technology-based self-learning module might improve dermatology teaching. (Source: Journal of the European Academy of Dermatology and Venereology)

Basement membrane antibodies in sera of haematopoietic cell recipients are associated with graft-versus-host disease

Journal of the European Academy of Dermatology and Venereology — Tue, 10 Nov 2009 00:00:00 +0100

Conclusions Circulating BMZ antibodies are significantly associated with chronic GvHD in contrast to uncomplicated HCT. Recurrent mucocutaneous lesions in chronic inflammatory skin disorders may liberate antigens, which may lead to production of BMZ antibodies, particularly in the context of GvHD-mediated reduced self-tolerance. (Source: Journal of the European Academy of Dermatology and Venereology)

CHILD syndrome: the NSDHL gene and its role in CHILD syndrome, a rare hereditary disorder

Journal of the European Academy of Dermatology and Venereology — Tue, 10 Nov 2009 00:00:00 +0100

Conclusions This is the first report of CHILD syndrome ever reported in Greece. We suggest that the diagnosis of the syndrome is important for patient information and genetic counselling. (Source: Journal of the European Academy of Dermatology and Venereology)

Multiple primary malignancies in patients with Merkel cell carcinoma1

Journal of the European Academy of Dermatology and Venereology — Mon, 09 Nov 2009 00:00:00 +0100

Conclusions Our figures reflect a higher incidence of multiple malignancies in those with Merkel cell tumour than has previously been reported. This has important implications for the care and surveillance of these patients. (Source: Journal of the European Academy of Dermatology and Venereology)

Long-term results after reconstruction of full thickness scalp defects with a dermal regeneration template

Journal of the European Academy of Dermatology and Venereology — Wed, 04 Nov 2009 00:00:00 +0100

Conclusion After reconstruction of full thickness scalp defects with Integra®, the cosmetic results are appealing and we observed no local recurrences during the follow-up period. (Source: Journal of the European Academy of Dermatology and Venereology)

A novel splicing mutation and haplotype analysis of the FECH gene in a Chinese family with erythropoietic protoporphyria

Journal of the European Academy of Dermatology and Venereology — Mon, 02 Nov 2009 00:00:00 +0100

Conclusion We described a novel splicing FECH mutation in a Chinese EPP family and analysed the hypomorphic IVS3-48C allele, which were believed to be responsible for generating the phenotypic symptoms in this family. (Source: Journal of the European Academy of Dermatology and Venereology)

Environmental dew point and skin and lip weathering

Journal of the European Academy of Dermatology and Venereology — Mon, 02 Nov 2009 00:00:00 +0100

This study aimed to assess the relationship between the environmental DP and the water-holding capacity of the skin and lower lip vermilion. For comparison, SC property was evaluated after occlusive application of cooled and uncooled hydrogel pads. Electrometric measurements using a dermal phase meter (DPM) device were performed on the back of the hands, the cheeks and the lower lip of 40 healthy menopausal women. Assessments were performed in the outdoor conditions during winter and spring. The same measurements were recorded after hydrogel pads, at room temperature or cooled to 4 °C, were placed for 15 min on the test sites. The environmental DP was recorded at each evaluation time. The SC water-holding capacity was discretely influenced by the DP. In the open-air environmental conditio...

Seborrhoeic dermatitis among Oxford renal transplant recipients1

Journal of the European Academy of Dermatology and Venereology — Mon, 02 Nov 2009 00:00:00 +0100

Discussion Seborrhoeic dermatitis is more common than other inflammatory dermatoses in immunosuppressed RTRs, but is not as frequent as in those immunosuppressed secondary to HIV. Degree and duration of exposure to immunosuppression and increased colonization with Malassezia yeast genus are likely be important in the aetiology of seborrhoeic dermatitis in RTRs. Further studies are required to clarify this. (Source: Journal of the European Academy of Dermatology and Venereology)

Nail changes in patients with liver disease

Journal of the European Academy of Dermatology and Venereology — Mon, 02 Nov 2009 00:00:00 +0100

Conclusion Nail changes are observed with not only liver cirrhosis but also with HCV and HBV infection, and this will add additional clinical criteria for general practitioners and dermatologists to help them with diagnosis of these common systemic infections. (Source: Journal of the European Academy of Dermatology and Venereology)

Subclinical atherosclerosis in patients with chronic psoriasis: a potential association

Journal of the European Academy of Dermatology and Venereology — Mon, 02 Nov 2009 00:00:00 +0100

Conclusion The increased carotid artery IMT in patients with chronic psoriasis suggesting that chronic psoriasis is associated with subclinical atherosclerosis with increased risk of cardiovascular disease. So, dermatologists should advice their patients to avoid traditional cardiovascular risk factors and to routinely checkup to reduce cardiovascular morbidity and mortality. (Source: Journal of the European Academy of Dermatology and Venereology)

Haematological deficiencies in patients with recurrent aphthosis

Journal of the European Academy of Dermatology and Venereology — Mon, 02 Nov 2009 00:00:00 +0100

Conclusion The strong association with familiarity, the unexpected higher frequency of ALU (compared with the idiopathic variant) and the good response to replacement therapy means that familiarity should always be investigated. Furthermore, routine haematological screening and tests for serum iron, folic acid and vitamin B12 deficiencies should be assessed in all patients with recurrent aphthosis to treat any nutritional deficiency and to prevent more important related systemic manifestations. (Source: Journal of the European Academy of Dermatology and Venereology)

Risk factors associated with rosacea

Journal of the European Academy of Dermatology and Venereology — Fri, 23 Oct 2009 23:00:00 +0100

Conclusion Rosacea is foremost associated with familial predisposition. There is no association between Helicobacter pylori infection and rosacea in current study. (Source: Journal of the European Academy of Dermatology and Venereology)

The risk of psoriatic arthritis remains constant following initial diagnosis of psoriasis among patients seen in European dermatology clinics

Journal of the European Academy of Dermatology and Venereology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusions The incidence of PsA was constant after initial diagnosis of psoriasis, leading to a higher prevalence of concomitant PsA over time. PsA is associated with decreased QoL and increased work-related problems, HCRU and comorbidities. Dermatologists should screen for PsA in their patients, especially long-standing patients who did not initially present with PsA. (Source: Journal of the European Academy of Dermatology and Venereology)

Analysis of four prevalent filaggrin mutations (R501X, 2282del4, R2447X and S3247X) in Austrian and German patients with atopic dermatitis

Journal of the European Academy of Dermatology and Venereology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusion Our data confirm and extend the knowledge of the influence of FLG mutations in AD. (Source: Journal of the European Academy of Dermatology and Venereology)

An Italian shared dermatological and rheumatological proposal for the use of biological agents in psoriatic disease

Journal of the European Academy of Dermatology and Venereology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusion We provide a shared dermatological and rheumatological proposal for the use of biological agents in PD. (Source: Journal of the European Academy of Dermatology and Venereology)

Retrospective analysis of systemic treatments for psoriasis patients attending a Psocare center in Florence. Relevance of biological drugs use and comorbidities

Journal of the European Academy of Dermatology and Venereology — Thu, 22 Oct 2009 23:00:00 +0100

Conclusions Current treatments have to consider general health conditions and patients habits. In this picture, biological drugs are emerging as the therapy of choice for their good efficacy in the long term management of psoriasis. (Source: Journal of the European Academy of Dermatology and Venereology)

Successful treatment of cheilitis granulomatosa with intralesional injection of triamcinolone

Journal of the European Academy of Dermatology and Venereology — Wed, 21 Oct 2009 23:00:00 +0100

(Source: Journal of the European Academy of Dermatology and Venereology)

Treatment of scalp psoriasis with clobetasol-17 propionate 0.05% shampoo: a study on daily clinical practice

Journal of the European Academy of Dermatology and Venereology — Tue, 20 Oct 2009 23:00:00 +0100

Conclusions Short-contact treatment with clobetasol-17 propionate 0.05% shampoo has high user convenience and patient satisfaction rates. Moreover, the treatment is well-tolerated and efficacious from patients' perspective. Subgroup analyses did not reveal factors predicting treatment outcome, although treatment success tended to be more evident in patients who had received fewer treatments previously. (Source: Journal of the European Academy of Dermatology and Venereology)

Internet-supported gathering of treatment data and patient benefits in psoriasis

Journal of the European Academy of Dermatology and Venereology — Tue, 20 Oct 2009 23:00:00 +0100

Conclusion The findings suggest that patients in the online sample are less satisfied with their health care, which also could have been their motive for participating online. It is important to gather data online because it increases the data pool and permits inclusion of people who are not incorporated in clinical settings. However, online data cannot directly replace data collected in clinics because they are also subject to selections. (Source: Journal of the European Academy of Dermatology and Venereology)

Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod – proposal of a therapeutic schedule

Journal of the European Academy of Dermatology and Venereology — Wed, 14 Oct 2009 23:00:00 +0100

Conclusion Based on our results, we consider that Imiquimod cream is a safe and effective therapeutic option for the treatment of vulvar EMPD. These promising results warrant further studies to determine the real efficacy and safety of Imiquimod 5% cream for the treatment of this uncommon disease. (Source: Journal of the European Academy of Dermatology and Venereology)