MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Korean J Hepatol' source. Sat, 30 Jan 2010 14:29:09 +0100 http://www.medworm.com/index.php?rid=3127041&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037261%26dopt%3DAbstract Authors: Seo YS PMID: 20037261 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127041 Tue, 01 Dec 2009 00:00:00 +0100 3127041 http://www.medworm.com/index.php?rid=3127040&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037262%26dopt%3DAbstract Authors: Jung YK, Kim JH Acute viral hepatitis A has recently become a major public health problem in Korea, and the incidence of symptomatic hepatitis A is growing rapidly. With improvements in socioeconomic conditions and environmental hygiene, the chances of exposure to hepatitis A virus (HAV) during childhood have decreased and, in turn, the proportion of young adults with positive anti-HAV has significantly decreased. This has led to the incidence of symptomatic acute hepatitis A increasing since the late 1990s. The incidence of serious complications including fulminant hepatic failure and acute kidney injury has also showed an increasing trend. Variation of the genotype of virus isolated from recent hepatitis A patients suggests an inflow of the hepatitis virus from other countri... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127040 Tue, 01 Dec 2009 00:00:00 +0100 3127040 http://www.medworm.com/index.php?rid=3127039&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037263%26dopt%3DAbstract CONCLUSIONS: Entecavir induced excellent biochemical and virologic responses in naive CHB patients. EVR was an independent factor for predicting HBV PCR negativity and HBeAg loss. PMID: 20037263 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127039 Tue, 01 Dec 2009 00:00:00 +0100 3127039 http://www.medworm.com/index.php?rid=3127038&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037264%26dopt%3DAbstract CONCLUSIONS: All noninvasive serum markers evaluated in this study were useful for predicting significant or extensive liver fibrosis in chronic viral liver diseases. In particular, APRI was most useful for the prediction of significant fibrosis, and CDS was most useful for the prediction of extensive fibrosis. PMID: 20037264 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127038 Tue, 01 Dec 2009 00:00:00 +0100 3127038 http://www.medworm.com/index.php?rid=3127037&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037265%26dopt%3DAbstract CONCLUSIONS: Liver stiffness as measured by transient elastography is associated with the grade of necroinflammatory activity and the stage of fibrosis, irrespective of serum ALT levels. PMID: 20037265 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127037 Tue, 01 Dec 2009 00:00:00 +0100 3127037 http://www.medworm.com/index.php?rid=3127036&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037266%26dopt%3DAbstract CONCLUSIONS: TACE and RFA exhibited similar therapeutic effects in terms of recurrence and survival for patients with a single HCC smaller than 4 cm, if they could exhibited complete responses. PMID: 20037266 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127036 Tue, 01 Dec 2009 00:00:00 +0100 3127036 http://www.medworm.com/index.php?rid=3127035&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037267%26dopt%3DAbstract CONCLUSIONS: The up-regulated expression of FZD10 and CAMK2A suggests that the Wnt/Ca(2+) signaling pathway is active in hTERT HSCs and may participate in HSC activation and proliferation. PMID: 20037267 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127035 Tue, 01 Dec 2009 00:00:00 +0100 3127035 http://www.medworm.com/index.php?rid=3127034&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037268%26dopt%3DAbstract CONCLUSIONS: The 24-week plus additional split 24-week therapy following failure is a useful treatment strategy for patients with genotype 1 CHC. PMID: 20037268 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127034 Tue, 01 Dec 2009 00:00:00 +0100 3127034 http://www.medworm.com/index.php?rid=3127033&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037269%26dopt%3DAbstract We describe two cases of symptomatic toxic hepatitis that developed in middle-aged women after ingesting arrowroot juice. The clinical manifestations were nausea, vomiting, and jaundice. The diagnosis of toxic hepatitis was made using the Roussel Uclaf Causality Assessment Method score on the basis of the patient's history and laboratory data. After supportive care, the patients showed rapid improvements of clinical symptoms, laboratory findings, and liver stiffness. Clinicians should be aware that the consumption of arrowroot juice can cause toxic hepatitis. PMID: 20037269 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127033 Tue, 01 Dec 2009 00:00:00 +0100 3127033 http://www.medworm.com/index.php?rid=3127032&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037270%26dopt%3DAbstract We present a case of primary hepatic epithelioid hemangioendothelioma in a 65-year-old male patient with alcoholic liver cirrhosis. He was hospitalized due to epigastric pain and multiple liver masses on abdominal ultrasound. Dynamic liver CT imaging revealed multiple peripheral nodular enhanced mass lesions with delayed centripetal enhancement, and the adjacent collection of high-attenuation fluid along the liver capsule. Abdominal tapping revealed blood in the peritoneal cavity. Primary hepatic epithelioid hemangioendothelioma with spontaneous rupture was finally diagnosed based on a histopathologic examination revealing positive immunohistochemical staining for CD34. PMID: 20037270 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127032 Tue, 01 Dec 2009 00:00:00 +0100 3127032 http://www.medworm.com/index.php?rid=3127031&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037271%26dopt%3DAbstract We report herein a case of hepatotoxicity induced by Corydalis speciosa Max. A 37-year-old male complained of jaundice and mild abdominal discomfort. A thorough history was taken, and laboratory investigation, diagnostic imaging studies, and percutaneous liver biopsy sampling were conducted to determine the cause of liver injury. An accurate cause was not revealed. We administered supportive management for acute cholestatic hepatitis of unknown origin, after which his symptoms disappeared and serum aminotransferase levels decreased gradually to near normal levels. However, at 2 months after discharge, the symptoms and the elevation of aminotransferase levels recurred. At that time he told us that he had repeatedly but unintentionally eaten a herb called "Hwang-geun cho"(Corydalis speciosa ... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127031 Tue, 01 Dec 2009 00:00:00 +0100 3127031 http://www.medworm.com/index.php?rid=3127030&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037272%26dopt%3DAbstract Authors: Jeen YM, Jin SY PMID: 20037272 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127030 Tue, 01 Dec 2009 00:00:00 +0100 3127030 http://www.medworm.com/index.php?rid=3127029&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037273%26dopt%3DAbstract Authors: Lee WJ PMID: 20037273 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127029 Tue, 01 Dec 2009 00:00:00 +0100 3127029 http://www.medworm.com/index.php?rid=3127028&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20037274%26dopt%3DAbstract Authors: Hahn T PMID: 20037274 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=3127028 Tue, 01 Dec 2009 00:00:00 +0100 3127028 http://www.medworm.com/index.php?rid=2843181&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783878%26dopt%3DAbstract Authors: Jin HS, Oh B PMID: 19783878 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843181 Mon, 31 Aug 2009 23:00:00 +0100 2843181 http://www.medworm.com/index.php?rid=2843180&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783879%26dopt%3DAbstract Authors: Song IH Hepatocellular carcinoma (HCC) is a major global health problem, which has a grave morbidity and mortality. Over the past few decades, no effective systemic therapeutic modalities have been established for patients with the unresectable HCC in advanced stage. Sorafenib is a small molecule that blocks cancer cell proliferation by targeting the intracellular signaling pathway at the level of Raf-1 and B-Raf serine-threonine kinases, and exerts an anti-angiogenic effect by targeting the vascular endothelial growth factor receptor-1, 2 and 3, and platelet-derived growth factor receptor-beta tyrosine kinases. Recently, two clinical successful applications, SHARP and Asia-Pacific trial, of multikinase inhibitor sorafenib represent a significant advance in the treatment of ad... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843180 Mon, 31 Aug 2009 23:00:00 +0100 2843180 http://www.medworm.com/index.php?rid=2843179&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783880%26dopt%3DAbstract CONCLUSIONS: The arche haplotype of the ATP7B gene in Korean patients with WD may be 5-R778L-4 (D13S315.mutation.D13S316), and it might illustrate a founder effect. PMID: 19783880 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843179 Mon, 31 Aug 2009 23:00:00 +0100 2843179 http://www.medworm.com/index.php?rid=2843178&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783881%26dopt%3DAbstract CONCLUSIONS: Serum OPN levels were significantly higher in patients with advanced HCC. In addition, HCC patients with low pretreatment serum OPN levels and those for whom serum OPN declined following TACE exhibited better tumor responses and survived for longer. PMID: 19783881 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843178 Mon, 31 Aug 2009 23:00:00 +0100 2843178 http://www.medworm.com/index.php?rid=2843177&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783882%26dopt%3DAbstract CONCLUSION: A 48-week course of clevudine therapy was highly effective in patients with CHB. The risk of development of resistance to clevudine was increased in patients with previous exposure to lamivudine and cirrhosis. PMID: 19783882 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843177 Mon, 31 Aug 2009 23:00:00 +0100 2843177 http://www.medworm.com/index.php?rid=2843176&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783883%26dopt%3DAbstract CONCLUSIONS: Adherence to therapy is a key factor in achieving an SVR. Supportive strategies to improve adherence will increase overall SVR rates. PMID: 19783883 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843176 Mon, 31 Aug 2009 23:00:00 +0100 2843176 http://www.medworm.com/index.php?rid=2843175&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783884%26dopt%3DAbstract CONCLUSIONS: Both MELD and HVPG are independent prognostic factors of death within 3 and 12 months in patients with decompensated liver cirrhosis, and their accuracies are similar. However, HVPG has a limited role in the prediction of death in decompensated cirrhosis due to its invasiveness and limited use. PMID: 19783884 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843175 Mon, 31 Aug 2009 23:00:00 +0100 2843175 http://www.medworm.com/index.php?rid=2843174&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783885%26dopt%3DAbstract We report a rare case of rib metastasis from HCC treated by transcatheter arterial chemoembolization (TACE). A 55-year-old man with liver cirrhosis presented with right lower chest pain. The diagnosis was an HCC with a bone metastasis in the right eighth rib. Intra-arterial injections of doxorubicin mixed with Lipiodol and Gelfoam particles were instituted through the right eighth intercostal artery. Computed tomography and a Tc(99)-labeled scan performed 2 months after the third TACE revealed no viable HCC in the right eighth rib. PMID: 19783885 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843174 Mon, 31 Aug 2009 23:00:00 +0100 2843174 http://www.medworm.com/index.php?rid=2843173&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783886%26dopt%3DAbstract We report four cases of hepatitis A in which patients presented with fulminant hepatitis and acute renal failure and underwent liver transplantation. The following common features were observed in our cases: (1) occurrence in relatively old age (>/=39 years old), (2) association with acute renal failure, (3) presence of hepatomegaly, and (4) microscopic features of submassive hepatic necrosis. PMID: 19783886 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843173 Mon, 31 Aug 2009 23:00:00 +0100 2843173 http://www.medworm.com/index.php?rid=2843172&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783887%26dopt%3DAbstract We report a 60-year-old male patient who developed sudden-onset hearing loss during combination therapy with pegylated interferon alpha and ribavirin for chronic hepatitis C. This patient had been diagnosed with chronic hepatitis C (genotype Ib) and early-stage liver cirrhosis 3 years previously, and had been treated with conventional interferon-alpha and ribavirin for 12 months. However, 6 months from the end of the treatment course the patient relapsed and received combination retreatment with pegylated interferon alpha-2b and ribavirin. He developed sudden-onset right-side hearing loss and tinnitus 42 weeks after the start of this retreatment. Pure-tone audiometry revealed a right-side hearing loss of 60~90dB. The patient consequently immediately discontinued the pegylated interferon th... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843172 Mon, 31 Aug 2009 23:00:00 +0100 2843172 http://www.medworm.com/index.php?rid=2843171&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783888%26dopt%3DAbstract Authors: Kim H, Park YN PMID: 19783888 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843171 Mon, 31 Aug 2009 23:00:00 +0100 2843171 http://www.medworm.com/index.php?rid=2843170&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783889%26dopt%3DAbstract Authors: Lee WJ PMID: 19783889 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843170 Mon, 31 Aug 2009 23:00:00 +0100 2843170 http://www.medworm.com/index.php?rid=2843169&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783890%26dopt%3DAbstract Authors: Kim JH PMID: 19783890 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843169 Mon, 31 Aug 2009 23:00:00 +0100 2843169 http://www.medworm.com/index.php?rid=2843168&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783891%26dopt%3DAbstract Authors: Hepatocellular carcinoma (HCC) is a major cancer in Korea, typically has a poor prognosis, and constitutes the majority of primary hepatic malignancies. It is the number one cause of death among people in their 50s in Korea. The five-year survival rate of liver cancer is poor; at 18.9%. Efforts to increase the survival rate through early diagnosis of HCC and optimal treatments are keenly needed. Western guideline for the management of HCC were developed, but these guidelines are somewhat unsuitable for Korean patients. Thus, the Korean Liver Cancer Study Group (KLCSG) and the National Cancer Center (NCC), Korea jointly produced the Clinical Practice Guidelines for HCC for the first time in Korea in 2003. Owing to medical advances over the following six years, diagnosis and t... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843168 Mon, 31 Aug 2009 23:00:00 +0100 2843168 http://www.medworm.com/index.php?rid=2843167&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19783892%26dopt%3DAbstract Authors: Cho JH, Yoon KH, Lee KE, Park do S, Lee YJ, Moon HB, Lee KR, Choi CS, Cho EY, Kim HC PMID: 19783892 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2843167 Mon, 31 Aug 2009 23:00:00 +0100 2843167 http://www.medworm.com/index.php?rid=2581438&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581763%26dopt%3DAbstract Authors: Lee KS PMID: 19581763 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581438 Sun, 31 May 2009 23:00:00 +0100 2581438 http://www.medworm.com/index.php?rid=2581437&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581764%26dopt%3DAbstract Authors: Jeen YM, Jin SY Nonalcoholic steatohepatitis (NASH), one of the NAFLDs (nonalcoholic fatty liver diseases), is regarded as a hepatic manifestation of metabolic syndrome. NASH can progress to cirrhosis, and possibly to hepatic malignancy. Currently, liver biopsy is the only reliable method of assessing the presence or absence of NASH and the stage of fibrosis. The finding of steatosis with evidence of hepatocyte injury such as inflammation, ballooning, degeneration, and/or fibrosis, is generally essential for making a diagnosis of NASH. However, its diagnostic criteria have not yet been established. The pathologic findings of NASH and related diseases, and the grading system currently in use are reviewed herein. PMID: 19581764 [PubMed - in process] (Source: Korean J Hepatol... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581437 Sun, 31 May 2009 23:00:00 +0100 2581437 http://www.medworm.com/index.php?rid=2581436&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581765%26dopt%3DAbstract CONCLUSIONS: Due to the adoptive immunity that was transferred from anti-HBs-positive donors, a seroconversion of HBsAg could occur in some HBsAg-positive recipients. HBsAg-positive donors had a lesser effect on the HBV serologic markers of recipients. However, a reactivation of HBV can occur following hematopoietic stem-cell transplantation in the cases of recipients or donors with a history of HBV, infection by an accompanying immune suppression. Therefore, prevention should be instigated. PMID: 19581765 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581436 Sun, 31 May 2009 23:00:00 +0100 2581436 http://www.medworm.com/index.php?rid=2581435&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581766%26dopt%3DAbstract CONCLUSIONS: The prevailing HBV genotype in Korea is C2; the other genotypes occur only rarely. Future studies should include confirmation of the detection of genotypes other than C. PMID: 19581766 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581435 Sun, 31 May 2009 23:00:00 +0100 2581435 http://www.medworm.com/index.php?rid=2581434&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581767%26dopt%3DAbstract CONCLUSIONS: The prognosis in patients with ruptured HCCs was poor with a 30-day mortality of 43.5%. The early deaths after the rupture of HCC were associated with elevated serum bilirubin levels, hepatic encephalopathy, and the massive or diffuse type of tumor morphology. PMID: 19581767 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581434 Sun, 31 May 2009 23:00:00 +0100 2581434 http://www.medworm.com/index.php?rid=2581433&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581768%26dopt%3DAbstract CONCLUSIONS: In patients with a protracted illness, hepatosplenomegaly and/or abnormal liver function tests, hepatic tuberculosis should be suspected, even in healthy young patients or patients with normal imaging findings. Patients with tuberculous abscess formation tend to respond poorly to antituberculosis therapy, and surgery could be considered in these patients. PMID: 19581768 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581433 Sun, 31 May 2009 23:00:00 +0100 2581433 http://www.medworm.com/index.php?rid=2581432&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581769%26dopt%3DAbstract CONCLUSIONS: Younger children (age <7 years old) have a higher chance of HBsAg clearance than older children after the treatment of HBeAg-positive chronic hepatitis B with lamivudine. PMID: 19581769 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581432 Sun, 31 May 2009 23:00:00 +0100 2581432 http://www.medworm.com/index.php?rid=2581431&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581770%26dopt%3DAbstract CONCLUSIONS: Clevudine is one of the recommended first-line medicines for the treatment of chronic hepatitis B, but it is not free from resistance, particularly in patients with a history of previous lamivudine treatment, but also in naive patients. Clevudine should be avoided in previously lamivudine-exposed patients. In addition, reelevation of serum AST and CPK levels is not a rare occurrence, and close observation and follow-up tests are essential. PMID: 19581770 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581431 Sun, 31 May 2009 23:00:00 +0100 2581431 http://www.medworm.com/index.php?rid=2581430&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581771%26dopt%3DAbstract We report herein a case of benign HHN mimicking hepatocellular carcinoma in a 32-year-old male alcoholic liver cirrhosis patient without viral hepatitis infection. PMID: 19581771 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581430 Sun, 31 May 2009 23:00:00 +0100 2581430 http://www.medworm.com/index.php?rid=2581429&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581772%26dopt%3DAbstract We report herein a case of hepatoid adenocarcinoma of the stomach with liver metastasis. Gastric carcinoma generally presents as adenocarcinoma and rarely shows a hepatoid pattern, which can produce alpha-fetoprotein (AFP). The stomach is one of the common sites at which hepatoid adenocarcinoma has been detected. A 75-year-old female patient was admitted to the hospital with a symptom of epigastric discomfort. Gastrofibroscopy revealed a large tumor occupying the greater curvature of the stomach body. The level of serum AFP was markedly increased. Abdominal computed tomography revealed multiple liver masses. Biopsy samples of the gastric lesion and liver masses finally confirmed her case as hepatoid adenocarcinoma in the stomach with liver metastasis. The AFP-producing gastric carcinoma ne... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581429 Sun, 31 May 2009 23:00:00 +0100 2581429 http://www.medworm.com/index.php?rid=2581428&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581773%26dopt%3DAbstract Authors: Kang HM, Park MJ, Hwang JM, Kim JW, Jeong SH A 63-year-old male experienced sudden diplopia after 9 weeks of administration of pegylated interferon (IFN) alpha-2b and ribavirin for chronic hepatitis C (CHC). Ophthalmologic examinations showed ptosis on the right upper lid and restricted right eye movement without any other neurological signs. A brain imaging study and repetitive nerve stimulation test indicated no abnormality. The acetylcholine receptor antibody titer and response to acetylcholinesterase inhibitors were negative, and the results of thyroid function tests were normal. The patient's ophthalmological symptoms improved rapidly 3 weeks after discontinuation of pegylated IFN alpha-2b and ribavirin. The ocular myasthenia associated with combination therapy of pegylat... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581428 Sun, 31 May 2009 23:00:00 +0100 2581428 http://www.medworm.com/index.php?rid=2581427&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581774%26dopt%3DAbstract Authors: Seok JY, Kim YB PMID: 19581774 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581427 Sun, 31 May 2009 23:00:00 +0100 2581427 http://www.medworm.com/index.php?rid=2581426&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581775%26dopt%3DAbstract Authors: Lee WJ PMID: 19581775 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581426 Sun, 31 May 2009 23:00:00 +0100 2581426 http://www.medworm.com/index.php?rid=2581425&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581776%26dopt%3DAbstract Authors: Heo J PMID: 19581776 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2581425 Sun, 31 May 2009 23:00:00 +0100 2581425 http://www.medworm.com/index.php?rid=2309369&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346780%26dopt%3DAbstract Authors: Park YG PMID: 19346780 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309369 Sun, 01 Mar 2009 05:00:00 +0100 2309369 http://www.medworm.com/index.php?rid=2309367&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346781%26dopt%3DAbstract Authors: Kim YJ, Lee HS Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) as an etiologic agent in 80% of cases, and is the major cause of death among HBV carriers. Family history of HCC is a known risk factor for the development of HCC among chronically HBV infected patients; therefore, genetic factors are likely to modify the risk of HCC. However, the genetic factors that determine progression to HCC remain mostly to be recovered. It is estimated that there are millions of single nucleotide polymorphisms (SNPs) within human genome and they are likely to explain much of the genetic diversity of individuals. In this review, the natural history of HBV infection and host genetic factors related to HCC, study design and target gene selection for the detection of SN... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309367 Sun, 01 Mar 2009 05:00:00 +0100 2309367 http://www.medworm.com/index.php?rid=2309365&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346782%26dopt%3DAbstract CONCLUSIONS: Lentivirus-mediated delivery of shRNA against HBx can effectively suppress the replication of HBV and reduce HBV cccDNA in cell culture systems. PMID: 19346782 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309365 Sun, 01 Mar 2009 05:00:00 +0100 2309365 http://www.medworm.com/index.php?rid=2309363&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346783%26dopt%3DAbstract CONCLUSIONS: Antiviral treatment of CHB with LMV or ADV for up to 5 years using the alternative antiviral agent as rescue medication appears to be a cost-effective strategy for both HBeAg-positive and HBeAg-negative CHB patients in Korea. Economic evaluation of antiviral therapies should be studied further and updated, particularly for newer agents. PMID: 19346783 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309363 Sun, 01 Mar 2009 05:00:00 +0100 2309363 http://www.medworm.com/index.php?rid=2309360&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346784%26dopt%3DAbstract CONCLUSIONS: Transient elastography is a useful method for diagnosing cirrhosis in patients with alcoholic liver disease. PMID: 19346784 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309360 Sun, 01 Mar 2009 05:00:00 +0100 2309360 http://www.medworm.com/index.php?rid=2309358&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346785%26dopt%3DAbstract CONCLUSIONS: Our data suggest that the adefovir-monotherapy-induced virologic response is not durable in most patients with LAMV-R HBeAg-positive CHB, especially in those with a high pretreatment HBV DNA level. PMID: 19346785 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309358 Sun, 01 Mar 2009 05:00:00 +0100 2309358 http://www.medworm.com/index.php?rid=2309356&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346786%26dopt%3DAbstract CONCLUSIONS: The results of our study suggest that RBP4 is a serologic marker for disease severity in patients with CLD. It could also be useful as an early marker of CLD and of the relative success of antiviral therapy. PMID: 19346786 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309356 Sun, 01 Mar 2009 05:00:00 +0100 2309356 http://www.medworm.com/index.php?rid=2309354&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346787%26dopt%3DAbstract CONCLUSIONS: Reappearance of HCV RNA after earlier achievement of an SVR might appear more frequently than previously reported. Close follow-up of these patients is recommended and the implication of temporary viremia should be determined in the future. PMID: 19346787 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309354 Sun, 01 Mar 2009 05:00:00 +0100 2309354 http://www.medworm.com/index.php?rid=2309352&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346788%26dopt%3DAbstract We report here a case of HCC that directly invaded the gallbladder, and that resembled gallbladder carcinoma invading the liver. PMID: 19346788 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309352 Sun, 01 Mar 2009 05:00:00 +0100 2309352 http://www.medworm.com/index.php?rid=2309350&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346789%26dopt%3DAbstract We report a case of acute hepatitis A complicated by rhabdomyolysis during hospitalization. PMID: 19346789 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309350 Sun, 01 Mar 2009 05:00:00 +0100 2309350 http://www.medworm.com/index.php?rid=2309348&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346790%26dopt%3DAbstract We report here a case of advanced HCC with portal vein tumor thrombosis that was effectively treated with percutaneous ethanol injection (PEI), having previously enabled subsequent successive transarterial chemoembolization (TACE). A 60-year-old male patient was diagnosed with a huge HCC, based on computed tomography and angiographic findings. Despite two sessions of TACE, the tumor invaded the right portal vein. PEI was performed on the malignant portal vein thrombosis, and three sessions thereof reduced the extent of tumor thrombi in the portal vein. Successive TACEs were performed to treat the HCC in the hepatic parenchyma. The patient was still living 19 months after the first PEI with no evidence of tumor recurrence, and his liver function remained well preserved. PMID: 19346790 [... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309348 Sun, 01 Mar 2009 05:00:00 +0100 2309348 http://www.medworm.com/index.php?rid=2309346&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346791%26dopt%3DAbstract Authors: Seok JY, Park YN PMID: 19346791 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309346 Sun, 01 Mar 2009 05:00:00 +0100 2309346 http://www.medworm.com/index.php?rid=2309344&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346792%26dopt%3DAbstract Authors: Lee WJ PMID: 19346792 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309344 Sun, 01 Mar 2009 05:00:00 +0100 2309344 http://www.medworm.com/index.php?rid=2309342&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19346793%26dopt%3DAbstract Authors: Park NH PMID: 19346793 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309342 Sun, 01 Mar 2009 05:00:00 +0100 2309342 http://www.medworm.com/index.php?rid=2309393&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119239%26dopt%3DAbstract Authors: Lee YJ PMID: 19119239 [PubMed - indexed for MEDLINE] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309393 Mon, 01 Dec 2008 05:00:00 +0100 2309393 http://www.medworm.com/index.php?rid=2309391&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119240%26dopt%3DAbstract Authors: Yim HJ Hepatitis B virus (HBV) is a partially double stranded DNA virus with genetic diversity represented by eight genotypes (A to H). Natural course and response to treatment could be affected by HBV genotypes. HBV shows high rates of turn over in the absence of proof-reading ability. As a result, large amounts of quasispecies are produced naturally or antiviral-associated. HBV consists of four open reading frames, namely preS/S gene, precore/core gene, polymerase gene, and X gene. Mutations on preS gene can result in undetectable HBsAg even in case that HBV is replicating. Surface gene mutation leads to decreased binding affinity to anti-HBs, which is associated with a vaccine escape mutant. Precore mutation abolishes HBeAg whereas mutations on basal core promoter gene down... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309391 Mon, 01 Dec 2008 05:00:00 +0100 2309391 http://www.medworm.com/index.php?rid=2309388&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119242%26dopt%3DAbstract CONCLUSIONS: FHF due to hepatitis A has increased in recent years, and in our cohort the HEP grade was closely associated with spontaneous survival. PMID: 19119242 [PubMed - indexed for MEDLINE] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309388 Mon, 01 Dec 2008 05:00:00 +0100 2309388 http://www.medworm.com/index.php?rid=2309386&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119243%26dopt%3DAbstract CONCLUSIONS: The main cause of acute toxic hepatitis in the current study was the use of herbal medicines. The severity of liver injury at the time of admission was a major factor significantly associated with the hospitalization and recovery periods. PMID: 19119243 [PubMed - indexed for MEDLINE] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309386 Mon, 01 Dec 2008 05:00:00 +0100 2309386 http://www.medworm.com/index.php?rid=2309383&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119244%26dopt%3DAbstract CONCLUSIONS: We found no significant differences in therapeutic efficacies and adverse effects between the alpha-2a and -2b types of peginterferon as the initial treatment regimen in naive chronic hepatitis C patients. PMID: 19119244 [PubMed - indexed for MEDLINE] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309383 Mon, 01 Dec 2008 05:00:00 +0100 2309383 http://www.medworm.com/index.php?rid=2309381&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119245%26dopt%3DAbstract CONCLUSIONS: Although ADV monotherapy is effective, it leads to a high rate of mutations of HBV DNA reverse transcriptase gene in patients with chronic HBV infections who have LMV-resistant HBV mutants. PMID: 19119245 [PubMed - indexed for MEDLINE] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309381 Mon, 01 Dec 2008 05:00:00 +0100 2309381 http://www.medworm.com/index.php?rid=2309379&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119246%26dopt%3DAbstract Authors: Hur WH, Woo HY, Jeong SW, You CR, Bae SH, Choi JY, Yoon SK The wide use of lamivudine in chronic hepatitis B has produced a monotonic increase in patients with lamivudine resistance. Therefore, treating lamivudine resistance in chronic hepatitis B is a major concern in clinical practice for the treatment of hepatitis B virus (HBV). There is conflicting evidence on the outcome of pegylated interferon alpha (PEG-IFN alpha) therapy against lamivudine-resistant HBV, which is due to mutations in the YMDD motif. We experienced a patient with chronic hepatitis B who was successfully treated with PEG-IFN alpha-2a after the development of virologic and biochemical breakthrough during lamivudine therapy. Virologic breakthrough was associated with the emergence of YMDD mutants 48 months ... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309379 Mon, 01 Dec 2008 05:00:00 +0100 2309379 http://www.medworm.com/index.php?rid=2309377&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119247%26dopt%3DAbstract We report the clinical course and antiviral response in a patient with FCH due to recurrent hepatitis C after cadaveric liver transplantation who was treated with pegylated interferon alpha-2a and ribavirin. PMID: 19119247 [PubMed - indexed for MEDLINE] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309377 Mon, 01 Dec 2008 05:00:00 +0100 2309377 http://www.medworm.com/index.php?rid=2309375&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119248%26dopt%3DAbstract We report a case of a 64-year old woman who underwent hepatic resection due to epithelioid hemangioendothelioma in the right lobe that progressed to extrahepatic metastases of the bone, pleura, and peritoneum 22 months later. However, after resection there was no primary hepatic recurrence. PMID: 19119248 [PubMed - indexed for MEDLINE] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309375 Mon, 01 Dec 2008 05:00:00 +0100 2309375 http://www.medworm.com/index.php?rid=2309373&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119249%26dopt%3DAbstract Authors: Jeen YM, Jin SY PMID: 19119249 [PubMed - indexed for MEDLINE] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309373 Mon, 01 Dec 2008 05:00:00 +0100 2309373 http://www.medworm.com/index.php?rid=2309371&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119250%26dopt%3DAbstract Authors: Lee WJ PMID: 19119250 [PubMed - indexed for MEDLINE] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2309371 Mon, 01 Dec 2008 05:00:00 +0100 2309371 http://www.medworm.com/index.php?rid=2077424&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119239%26dopt%3DAbstract Authors: Lee YJ PMID: 19119239 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2077424 Mon, 01 Dec 2008 05:00:00 +0100 2077424 http://www.medworm.com/index.php?rid=2077423&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119240%26dopt%3DAbstract Authors: Yim HJ Hepatitis B virus (HBV) is a partially double stranded DNA virus with genetic diversity represented by eight genotypes (A to H). Natural course and response to treatment could be affected by HBV genotypes. HBV shows high rates of turn over in the absence of proof-reading ability. As a result, large amounts of quasispecies are produced naturally or antiviral-associated. HBV consists of four open reading frames, namely preS/S gene, precore/core gene, polymerase gene, and X gene. Mutations on preS gene can result in undetectable HBsAg even in case that HBV is replicating. Surface gene mutation leads to decreased binding affinity to anti-HBs, which is associated with a vaccine escape mutant. Precore mutation abolishes HBeAg whereas mutations on basal core promoter gene down... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2077423 Mon, 01 Dec 2008 05:00:00 +0100 2077423 http://www.medworm.com/index.php?rid=2077422&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119241%26dopt%3DAbstract CONCLUSIONS: Severe hepatic inflammation can affect the LS findings and thus, care is required when assessing fibrosis stage using LS measurement in patients with severe inflammation. PMID: 19119241 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2077422 Mon, 01 Dec 2008 05:00:00 +0100 2077422 http://www.medworm.com/index.php?rid=2077421&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119242%26dopt%3DAbstract CONCLUSIONS: FHF due to hepatitis A has increased in recent years, and in our cohort the HEP grade was closely associated with spontaneous survival. PMID: 19119242 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2077421 Mon, 01 Dec 2008 05:00:00 +0100 2077421 http://www.medworm.com/index.php?rid=2077420&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119243%26dopt%3DAbstract CONCLUSIONS: The main cause of acute toxic hepatitis in the current study was the use of herbal medicines. The severity of liver injury at the time of admission was a major factor significantly associated with the hospitalization and recovery periods. PMID: 19119243 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2077420 Mon, 01 Dec 2008 05:00:00 +0100 2077420 http://www.medworm.com/index.php?rid=2077419&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119244%26dopt%3DAbstract CONCLUSIONS: We found no significant differences in therapeutic efficacies and adverse effects between the alpha-2a and -2b types of peginterferon as the initial treatment regimen in naive chronic hepatitis C patients. PMID: 19119244 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2077419 Mon, 01 Dec 2008 05:00:00 +0100 2077419 http://www.medworm.com/index.php?rid=2077418&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119245%26dopt%3DAbstract CONCLUSIONS: Although ADV monotherapy is effective, it leads to a high rate of mutations of HBV DNA reverse transcriptase gene in patients with chronic HBV infections who have LMV-resistant HBV mutants. PMID: 19119245 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2077418 Mon, 01 Dec 2008 05:00:00 +0100 2077418 http://www.medworm.com/index.php?rid=2077417&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119246%26dopt%3DAbstract Authors: Hur WH, Woo HY, Jeong SW, You CR, Bae SH, Choi JY, Yoon SK The wide use of lamivudine in chronic hepatitis B has produced a monotonic increase in patients with lamivudine resistance. Therefore, treating lamivudine resistance in chronic hepatitis B is a major concern in clinical practice for the treatment of hepatitis B virus (HBV). There is conflicting evidence on the outcome of pegylated interferon alpha (PEG-IFN alpha) therapy against lamivudine-resistant HBV, which is due to mutations in the YMDD motif. We experienced a patient with chronic hepatitis B who was successfully treated with PEG-IFN alpha-2a after the development of virologic and biochemical breakthrough during lamivudine therapy. Virologic breakthrough was associated with the emergence of YMDD mutants 48 months ... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2077417 Mon, 01 Dec 2008 05:00:00 +0100 2077417 http://www.medworm.com/index.php?rid=2077416&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119247%26dopt%3DAbstract We report the clinical course and antiviral response in a patient with FCH due to recurrent hepatitis C after cadaveric liver transplantation who was treated with pegylated interferon alpha-2a and ribavirin. PMID: 19119247 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2077416 Mon, 01 Dec 2008 05:00:00 +0100 2077416 http://www.medworm.com/index.php?rid=2077415&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119248%26dopt%3DAbstract We report a case of a 64-year old woman who underwent hepatic resection due to epithelioid hemangioendothelioma in the right lobe that progressed to extrahepatic metastases of the bone, pleura, and peritoneum 22 months later. However, after resection there was no primary hepatic recurrence. PMID: 19119248 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2077415 Mon, 01 Dec 2008 05:00:00 +0100 2077415 http://www.medworm.com/index.php?rid=2077414&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119249%26dopt%3DAbstract Authors: Jeen YM, Jin SY PMID: 19119249 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2077414 Mon, 01 Dec 2008 05:00:00 +0100 2077414 http://www.medworm.com/index.php?rid=2077413&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119250%26dopt%3DAbstract Authors: Lee WJ PMID: 19119250 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2077413 Mon, 01 Dec 2008 05:00:00 +0100 2077413 http://www.medworm.com/index.php?rid=2077412&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19119251%26dopt%3DAbstract Authors: Lee JH PMID: 19119251 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=2077412 Mon, 01 Dec 2008 05:00:00 +0100 2077412 http://www.medworm.com/index.php?rid=1857946&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815453%26dopt%3DAbstract Authors: Jang JW PMID: 18815453 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1857946 Mon, 01 Sep 2008 04:00:00 +0100 1857946 http://www.medworm.com/index.php?rid=1857945&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815454%26dopt%3DAbstract Authors: Bae SH Most liver diseases lead to hepatic dysfunction with organ failure. Liver transplantation is the best curative therapy, but it has some limitations such as donor shortage, possibility of rejection, and maintenance of immunosuppressant. New therapies have been actively searched for over several decades, primarily in the form of artificial liver support devices and hepatocyte transplantation, but both of these modalities remain experimental. Stem cells have recently shown promise in cell therapy because they have the capacity for self-renewal and multilineage differentiation, and are applicable to human diseases. Very recent reports of unexpected plasticity in adult bone marrow have raised hopes of stem cell therapy offering exciting therapeutic possibilities for patients... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1857945 Mon, 01 Sep 2008 04:00:00 +0100 1857945 http://www.medworm.com/index.php?rid=1857944&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815455%26dopt%3DAbstract CONCLUSIONS: In Korean patients with chronic hepatitis C, a regimen of peginterferon and ribavirin was more effective than a regimen of conventional interferon and ribavirin. This result is comparable to those from studies on Western patients as an initial treatment for chronic hepatitis C. PMID: 18815455 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1857944 Mon, 01 Sep 2008 04:00:00 +0100 1857944 http://www.medworm.com/index.php?rid=1857943&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815456%26dopt%3DAbstract CONCLUSIONS: GV bleeding was more frequent in patients with fundal varices than in patients with type 1 gastroesophageal varices, and large GV and poor liver function were risk factors for GV bleeding. Close observation and prophylaxis for variceal bleeding might be warranted in high-risk patients. PMID: 18815456 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1857943 Mon, 01 Sep 2008 04:00:00 +0100 1857943 http://www.medworm.com/index.php?rid=1857942&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815457%26dopt%3DAbstract CONCLUSIONS: LSM is useful for predicting the presence of EV in patients with cirrhosis but not their size. PMID: 18815457 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1857942 Mon, 01 Sep 2008 04:00:00 +0100 1857942 http://www.medworm.com/index.php?rid=1857941&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815458%26dopt%3DAbstract CONCLUSIONS: Survivin was down-regulated in the growth inhibition of hepatoma cells induced by a selective COX-2 inhibitor, NS-398, in a concentration- and time-dependent manner. These results suggest the therapeutic inhibition of COX-2 via suppression of survivin in HCC. PMID: 18815458 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1857941 Mon, 01 Sep 2008 04:00:00 +0100 1857941 http://www.medworm.com/index.php?rid=1857940&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815459%26dopt%3DAbstract CONCLUSIONS: We found that systemic chemotherapy was not effective in treating HCC presenting with multiple lung metastases. Improving the effectiveness of systemic treatment and selecting patients who would benefit from such treatment remains a major challenge. PMID: 18815459 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1857940 Mon, 01 Sep 2008 04:00:00 +0100 1857940 http://www.medworm.com/index.php?rid=1857939&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815460%26dopt%3DAbstract CONCLUSIONS: Preoperative serum AFP and AST levels were the independent risk factors for ER after surgical resection for HCC. Close postoperative surveillance is recommended for early detection of recurrence and additional treatments in patients with these factors. PMID: 18815460 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1857939 Mon, 01 Sep 2008 04:00:00 +0100 1857939 http://www.medworm.com/index.php?rid=1857938&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815461%26dopt%3DAbstract Authors: Lee HJ, Choi JW, Kim TN, Eun JR Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus (HBV) replication but exhibits nephrotoxicity with severe hypophosphatemia when administered at a high dosage. This is the first report of severe hypophosphatemic osteomalacia induced by ADV at 10 mg/day. A 42-year-old man with HBV-related chronic liver disease presented with generalized bone pain, especially in the left ankle. He had been taking ADV for more than 1.5 years following a clinical breakthrough due to lamivudine-resistant HBV. Aggravating severe hypophosphatemia and elevated serum alkaline phosphatase levels with high bone fraction had been noted after 6 months of ADV therapy. Bone densitometry, simple bone X-rays, and a whole-body bone scan demonstrated osteoporosis ... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1857938 Mon, 01 Sep 2008 04:00:00 +0100 1857938 http://www.medworm.com/index.php?rid=1857937&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815462%26dopt%3DAbstract We report three cases of multiple infarcted regenerative nodules in liver cirrhosis after gastrointestinal hemorrhage. PMID: 18815462 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1857937 Mon, 01 Sep 2008 04:00:00 +0100 1857937 http://www.medworm.com/index.php?rid=1857936&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815463%26dopt%3DAbstract We report two cases of hepatocellular carcinoma with prominent lymphocytic infiltration, which has been described as a subtype of hepatocellular carcinoma with good prognosis. One case showed lymphoid follicles and dense lymphocytic infiltrates within the tumor and its periphery, and the other case showed marked lymphocytic infiltration in the cancerous tissue. Piecemeal necrosis of cancer cells and atypical reactive changes were evident. The two cases were seronegative for hepatitis B surface antigen, antibody to hepatitis C virus, and Epstein-Barr virus DNA. One of the cases showed Clonorchis infestation. The prognostic significance of lymphocytic stroma in hepatocellular carcinoma requires further investigation. PMID: 18815463 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1857936 Mon, 01 Sep 2008 04:00:00 +0100 1857936 http://www.medworm.com/index.php?rid=1857935&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815464%26dopt%3DAbstract Authors: Kim YB PMID: 18815464 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1857935 Mon, 01 Sep 2008 04:00:00 +0100 1857935 http://www.medworm.com/index.php?rid=1857934&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815465%26dopt%3DAbstract Authors: Han JK, Eun HW, Kim SH PMID: 18815465 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1857934 Mon, 01 Sep 2008 04:00:00 +0100 1857934 http://www.medworm.com/index.php?rid=1831534&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815453%26dopt%3DAbstract Authors: Jang JW PMID: 18815453 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831534 Mon, 01 Sep 2008 04:00:00 +0100 1831534 http://www.medworm.com/index.php?rid=1831533&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815454%26dopt%3DAbstract Authors: Bae SH Most liver diseases lead to hepatic dysfunction with organ failure. Liver transplantation is the best curative therapy, but it has some limitations such as donor shortage, possibility of rejection, and maintenance of immunosuppressant. New therapies have been actively searched for over several decades, primarily in the form of artificial liver support devices and hepatocyte transplantation, but both of these modalities remain experimental. Stem cells have recently shown promise in cell therapy because they have the capacity for self-renewal and multilineage differentiation, and are applicable to human diseases. Very recent reports of unexpected plasticity in adult bone marrow have raised hopes of stem cell therapy offering exciting therapeutic possibilities for patients... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831533 Mon, 01 Sep 2008 04:00:00 +0100 1831533 http://www.medworm.com/index.php?rid=1831532&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815455%26dopt%3DAbstract CONCLUSIONS: In Korean patients with chronic hepatitis C, a regimen of peginterferon and ribavirin was more effective than a regimen of conventional interferon and ribavirin. This result is comparable to those from studies on Western patients as an initial treatment for chronic hepatitis C. PMID: 18815455 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831532 Mon, 01 Sep 2008 04:00:00 +0100 1831532 http://www.medworm.com/index.php?rid=1831531&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815456%26dopt%3DAbstract CONCLUSIONS: GV bleeding was more frequent in patients with fundal varices than in patients with type 1 gastroesophageal varices, and large GV and poor liver function were risk factors for GV bleeding. Close observation and prophylaxis for variceal bleeding might be warranted in high-risk patients. PMID: 18815456 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831531 Mon, 01 Sep 2008 04:00:00 +0100 1831531 http://www.medworm.com/index.php?rid=1831530&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815457%26dopt%3DAbstract CONCLUSIONS: LSM is useful for predicting the presence of EV in patients with cirrhosis but not their size. PMID: 18815457 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831530 Mon, 01 Sep 2008 04:00:00 +0100 1831530 http://www.medworm.com/index.php?rid=1831529&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815458%26dopt%3DAbstract CONCLUSIONS: Survivin was down-regulated in the growth inhibition of hepatoma cells induced by a selective COX-2 inhibitor, NS-398, in a concentration- and time-dependent manner. These results suggest the therapeutic inhibition of COX-2 via suppression of survivin in HCC. PMID: 18815458 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831529 Mon, 01 Sep 2008 04:00:00 +0100 1831529 http://www.medworm.com/index.php?rid=1831528&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815459%26dopt%3DAbstract CONCLUSIONS: We found that systemic chemotherapy was not effective in treating HCC presenting with multiple lung metastases. Improving the effectiveness of systemic treatment and selecting patients who would benefit from such treatment remains a major challenge. PMID: 18815459 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831528 Mon, 01 Sep 2008 04:00:00 +0100 1831528 http://www.medworm.com/index.php?rid=1831527&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815460%26dopt%3DAbstract CONCLUSIONS: Preoperative serum AFP and AST levels were the independent risk factors for ER after surgical resection for HCC. Close postoperative surveillance is recommended for early detection of recurrence and additional treatments in patients with these factors. PMID: 18815460 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831527 Mon, 01 Sep 2008 04:00:00 +0100 1831527 http://www.medworm.com/index.php?rid=1831526&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815461%26dopt%3DAbstract Authors: Lee HJ, Choi JW, Kim TN, Eun JR Adefovir dipivoxyl (ADV) effectively suppresses hepatitis B virus (HBV) replication but exhibits nephrotoxicity with severe hypophosphatemia when administered at a high dosage. This is the first report of severe hypophosphatemic osteomalacia induced by ADV at 10 mg/day. A 42-year-old man with HBV-related chronic liver disease presented with generalized bone pain, especially in the left ankle. He had been taking ADV for more than 1.5 years following a clinical breakthrough due to lamivudine-resistant HBV. Aggravating severe hypophosphatemia and elevated serum alkaline phosphatase levels with high bone fraction had been noted after 6 months of ADV therapy. Bone densitometry, simple bone X-rays, and a whole-body bone scan demonstrated osteoporosis ... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831526 Mon, 01 Sep 2008 04:00:00 +0100 1831526 http://www.medworm.com/index.php?rid=1831525&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815462%26dopt%3DAbstract We report three cases of multiple infarcted regenerative nodules in liver cirrhosis after gastrointestinal hemorrhage. PMID: 18815462 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831525 Mon, 01 Sep 2008 04:00:00 +0100 1831525 http://www.medworm.com/index.php?rid=1831524&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815463%26dopt%3DAbstract We report two cases of hepatocellular carcinoma with prominent lymphocytic infiltration, which has been described as a subtype of hepatocellular carcinoma with good prognosis. One case showed lymphoid follicles and dense lymphocytic infiltrates within the tumor and its periphery, and the other case showed marked lymphocytic infiltration in the cancerous tissue. Piecemeal necrosis of cancer cells and atypical reactive changes were evident. The two cases were seronegative for hepatitis B surface antigen, antibody to hepatitis C virus, and Epstein-Barr virus DNA. One of the cases showed Clonorchis infestation. The prognostic significance of lymphocytic stroma in hepatocellular carcinoma requires further investigation. PMID: 18815463 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831524 Mon, 01 Sep 2008 04:00:00 +0100 1831524 http://www.medworm.com/index.php?rid=1831523&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815464%26dopt%3DAbstract Authors: Kim YB PMID: 18815464 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831523 Mon, 01 Sep 2008 04:00:00 +0100 1831523 http://www.medworm.com/index.php?rid=1831522&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815465%26dopt%3DAbstract Authors: Han JK, Eun HW, Kim SH PMID: 18815465 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831522 Mon, 01 Sep 2008 04:00:00 +0100 1831522 http://www.medworm.com/index.php?rid=1831521&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18815466%26dopt%3DAbstract Authors: Kim HJ PMID: 18815466 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1831521 Mon, 01 Sep 2008 04:00:00 +0100 1831521 http://www.medworm.com/index.php?rid=1629456&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617759%26dopt%3DAbstract Authors: Kim DJ, Kim HS, Yim HJ, Suh JI, Cheong JY, Kim IH, Tark WY, Lee YS, Lee S, Lee JY PMID: 18617759 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629456 Sun, 01 Jun 2008 04:00:00 +0100 1629456 http://www.medworm.com/index.php?rid=1629455&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617760%26dopt%3DAbstract Authors: Paik YH PMID: 18617760 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629455 Sun, 01 Jun 2008 04:00:00 +0100 1629455 http://www.medworm.com/index.php?rid=1629454&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617761%26dopt%3DAbstract Authors: Lee SO Cholangiocytes (epithelial cells lining the intra- and extrahepatic bile ducts) and hepatocytes are two major components of liver epithelia. Although cholangiocytes are less numerous than hepatocytes, they are involved in both bile secretion and diverse cellular processes such as cell-cycle phenomena, cell signaling, and interactions with other cells, matrix components, foreign organisms, and xenobiotics. Cholangiocytes are also targets in several human diseases including cholangiocarcinoma, primary sclerosing cholangitis, autoimmune cholangitis, and vanishing bile-duct syndrome. The rapid advances in experimental biology technologies are greatly expanding interest in and knowledge of the physiology and pathophysiology of cholangiocytes. This review focuses on the progr... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629454 Sun, 01 Jun 2008 04:00:00 +0100 1629454 http://www.medworm.com/index.php?rid=1629453&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617762%26dopt%3DAbstract CONCLUSIONS: HVPG was correlated with the severity of liver cirrhosis, presence of ascites, and risk of variceal bleeding in patients with liver cirrhosis. PMID: 18617762 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629453 Sun, 01 Jun 2008 04:00:00 +0100 1629453 http://www.medworm.com/index.php?rid=1629452&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617763%26dopt%3DAbstract CONCLUSIONS: These results indicate that serum HA is a useful and noninvasive serologic marker for the evaluation of advanced hepatic fibrosis. PMID: 18617763 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629452 Sun, 01 Jun 2008 04:00:00 +0100 1629452 http://www.medworm.com/index.php?rid=1629451&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617764%26dopt%3DAbstract CONCLUSIONS: The incidence of ARF after TACE was 3.2%, and the presence of ascites and an abnormal baseline serum creatinine level were the risk factors for ARF. PMID: 18617764 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629451 Sun, 01 Jun 2008 04:00:00 +0100 1629451 http://www.medworm.com/index.php?rid=1629450&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617765%26dopt%3DAbstract CONCLUSIONS: Symptoms and physical findings suggestive of PID are not present in many patients with Fitz-Hugh-Curtis syndrome. When a premenopausal woman complains of upper abdominal pain and shows CT findings compatible with perihepatitis, examination of cervical discharge would be recommended to assess the possibility of Fitz-Hugh-Curtis syndrome. PMID: 18617765 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629450 Sun, 01 Jun 2008 04:00:00 +0100 1629450 http://www.medworm.com/index.php?rid=1629449&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617766%26dopt%3DAbstract CONCLUSIONS: Our study showed that the expression of VEGF-A is positively correlated with the recurrence rate of HCC after curative resection. Therefore, a high expression of VEGF-A might be predictive of HCC recurrence after curative resection. PMID: 18617766 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629449 Sun, 01 Jun 2008 04:00:00 +0100 1629449 http://www.medworm.com/index.php?rid=1629448&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617767%26dopt%3DAbstract CONCLUSIONS: The expression pattern of HBcAg (including its possible absence) before initial therapy appears to predict the response to antiviral treatment. PMID: 18617767 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629448 Sun, 01 Jun 2008 04:00:00 +0100 1629448 http://www.medworm.com/index.php?rid=1629447&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617768%26dopt%3DAbstract We report four cases of toxic hepatitis that occurred after taking a decoction made by boiling down the root of Dictamnus dasycarpus. The four patients had a median age of 60 years, common symptoms of jaundice and general weakness, and stated that they had not consumed alcohol for at least 5 years. The markers of hepatitis A, B, and C were all negative in the patients. Abdominal ultrasonography revealed common bile ducts with normal diameters. Two of the cases were a mother and daughter, and the other two were sporadic. All of them had consumed a decoction made by boiling down the root of Dictamnus dasycarpus five or six times daily until several days before admission. Dictamnus dasycarpus induced liver injury presenting with a benign course lasting less than 1 month after cessation of the... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629447 Sun, 01 Jun 2008 04:00:00 +0100 1629447 http://www.medworm.com/index.php?rid=1629446&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617769%26dopt%3DAbstract Authors: Lim SM, Jang JW, Kim BW, Choi H, Choi KY, Park SJ, Han CW It is generally accepted that seroconversion of hepatitis B virus (HBV) surface antigen (HBsAg) to an antibody to HBsAg (anti-HBs) indicates clearance of HBV. Here we report a case of severe hepatitis that manifested during chemotherapy in a female patient with chronic lymphocytic leukemia (CLL) who had been initially seronegative for HBsAg and seropositive for anti-HBs. The patient received chlorambucil and prednisolone for the treatment of CLL. After 6 months the serum levels of aminotransferases were increased, and HBsAg and HBV DNA were present in serum. Lamivudine was administered immediately after confirming the HBV reactivation, which considerably improved jaundice and aminotransferase levels after 3 weeks. The p... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629446 Sun, 01 Jun 2008 04:00:00 +0100 1629446 http://www.medworm.com/index.php?rid=1629445&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617771%26dopt%3DAbstract Authors: Kim H, Park YN PMID: 18617771 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629445 Sun, 01 Jun 2008 04:00:00 +0100 1629445 http://www.medworm.com/index.php?rid=1629444&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617772%26dopt%3DAbstract Authors: Han JK, Eun HW, Kim SH PMID: 18617772 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629444 Sun, 01 Jun 2008 04:00:00 +0100 1629444 http://www.medworm.com/index.php?rid=1629443&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617773%26dopt%3DAbstract Authors: Kwon SY PMID: 18617773 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1629443 Sun, 01 Jun 2008 04:00:00 +0100 1629443 http://www.medworm.com/index.php?rid=1611832&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617759%26dopt%3DAbstract Authors: Kim DJ, Kim HS, Yim HJ, Suh JI, Cheong JY, Kim IH, Tark WY, Lee YS, Lee S, Lee JY PMID: 18617759 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611832 Sun, 01 Jun 2008 04:00:00 +0100 1611832 http://www.medworm.com/index.php?rid=1611831&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617760%26dopt%3DAbstract Authors: Paik YH PMID: 18617760 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611831 Sun, 01 Jun 2008 04:00:00 +0100 1611831 http://www.medworm.com/index.php?rid=1611830&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617761%26dopt%3DAbstract Authors: Lee SO Cholangiocytes (epithelial cells lining the intra- and extrahepatic bile ducts) and hepatocytes are two major components of liver epithelia. Although cholangiocytes are less numerous than hepatocytes, they are involved in both bile secretion and diverse cellular processes such as cell-cycle phenomena, cell signaling, and interactions with other cells, matrix components, foreign organisms, and xenobiotics. Cholangiocytes are also targets in several human diseases including cholangiocarcinoma, primary sclerosing cholangitis, autoimmune cholangitis, and vanishing bile-duct syndrome. The rapid advances in experimental biology technologies are greatly expanding interest in and knowledge of the physiology and pathophysiology of cholangiocytes. This review focuses on the progr... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611830 Sun, 01 Jun 2008 04:00:00 +0100 1611830 http://www.medworm.com/index.php?rid=1611829&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617762%26dopt%3DAbstract CONCLUSIONS: HVPG was correlated with the severity of liver cirrhosis, presence of ascites, and risk of variceal bleeding in patients with liver cirrhosis. PMID: 18617762 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611829 Sun, 01 Jun 2008 04:00:00 +0100 1611829 http://www.medworm.com/index.php?rid=1611828&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617763%26dopt%3DAbstract CONCLUSIONS: These results indicate that serum HA is a useful and noninvasive serologic marker for the evaluation of advanced hepatic fibrosis. PMID: 18617763 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611828 Sun, 01 Jun 2008 04:00:00 +0100 1611828 http://www.medworm.com/index.php?rid=1611827&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617764%26dopt%3DAbstract CONCLUSIONS: The incidence of ARF after TACE was 3.2%, and the presence of ascites and an abnormal baseline serum creatinine level were the risk factors for ARF. PMID: 18617764 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611827 Sun, 01 Jun 2008 04:00:00 +0100 1611827 http://www.medworm.com/index.php?rid=1611826&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617765%26dopt%3DAbstract CONCLUSIONS: Symptoms and physical findings suggestive of PID are not present in many patients with Fitz-Hugh-Curtis syndrome. When a premenopausal woman complains of upper abdominal pain and shows CT findings compatible with perihepatitis, examination of cervical discharge would be recommended to assess the possibility of Fitz-Hugh-Curtis syndrome. PMID: 18617765 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611826 Sun, 01 Jun 2008 04:00:00 +0100 1611826 http://www.medworm.com/index.php?rid=1611825&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617766%26dopt%3DAbstract CONCLUSIONS: Our study showed that the expression of VEGF-A is positively correlated with the recurrence rate of HCC after curative resection. Therefore, a high expression of VEGF-A might be predictive of HCC recurrence after curative resection. PMID: 18617766 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611825 Sun, 01 Jun 2008 04:00:00 +0100 1611825 http://www.medworm.com/index.php?rid=1611824&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617767%26dopt%3DAbstract CONCLUSIONS: The expression pattern of HBcAg (including its possible absence) before initial therapy appears to predict the response to antiviral treatment. PMID: 18617767 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611824 Sun, 01 Jun 2008 04:00:00 +0100 1611824 http://www.medworm.com/index.php?rid=1611823&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617768%26dopt%3DAbstract We report four cases of toxic hepatitis that occurred after taking a decoction made by boiling down the root of Dictamnus dasycarpus. The four patients had a median age of 60 years, common symptoms of jaundice and general weakness, and stated that they had not consumed alcohol for at least 5 years. The markers of hepatitis A, B, and C were all negative in the patients. Abdominal ultrasonography revealed common bile ducts with normal diameters. Two of the cases were a mother and daughter, and the other two were sporadic. All of them had consumed a decoction made by boiling down the root of Dictamnus dasycarpus five or six times daily until several days before admission. Dictamnus dasycarpus induced liver injury presenting with a benign course lasting less than 1 month after cessation of the... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611823 Sun, 01 Jun 2008 04:00:00 +0100 1611823 http://www.medworm.com/index.php?rid=1611822&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617769%26dopt%3DAbstract Authors: Lim SM, Jang JW, Kim BW, Choi H, Choi KY, Park SJ, Han CW It is generally accepted that seroconversion of hepatitis B virus (HBV) surface antigen (HBsAg) to an antibody to HBsAg (anti-HBs) indicates clearance of HBV. Here we report a case of severe hepatitis that manifested during chemotherapy in a female patient with chronic lymphocytic leukemia (CLL) who had been initially seronegative for HBsAg and seropositive for anti-HBs. The patient received chlorambucil and prednisolone for the treatment of CLL. After 6 months the serum levels of aminotransferases were increased, and HBsAg and HBV DNA were present in serum. Lamivudine was administered immediately after confirming the HBV reactivation, which considerably improved jaundice and aminotransferase levels after 3 weeks. The p... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611822 Sun, 01 Jun 2008 04:00:00 +0100 1611822 http://www.medworm.com/index.php?rid=1611821&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617770%26dopt%3DAbstract We report a rare case of GSD III in an adult. A 52-year-old woman presented to our clinic due to dyspnea on exertion, severe general weakness, and hepatomegaly. Hypertrophic cardiomyopathy was diagnosed based on echocardiogram findings. The microscopic findings of liver and skeletal muscle biopsies were consistent with the diagnosis of GSD. DNA analysis prompted by clinical and pathologic findings led to a definitive diagnosis of GSD IIIa. Diet therapy with cornstarch was started, and the patient was followed closely. This represents the first reported case of GSD IIIa diagnosed in an adult in Korea. PMID: 18617770 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611821 Sun, 01 Jun 2008 04:00:00 +0100 1611821 http://www.medworm.com/index.php?rid=1611820&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617771%26dopt%3DAbstract Authors: Kim H, Park YN PMID: 18617771 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611820 Sun, 01 Jun 2008 04:00:00 +0100 1611820 http://www.medworm.com/index.php?rid=1611819&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617772%26dopt%3DAbstract Authors: Han JK, Eun HW, Kim SH PMID: 18617772 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611819 Sun, 01 Jun 2008 04:00:00 +0100 1611819 http://www.medworm.com/index.php?rid=1611818&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18617773%26dopt%3DAbstract Authors: Kwon SY PMID: 18617773 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1611818 Sun, 01 Jun 2008 04:00:00 +0100 1611818 http://www.medworm.com/index.php?rid=1553843&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18367852%26dopt%3DAbstract Authors: Kim MY, Baik SK PMID: 18367852 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1553843 Sat, 01 Mar 2008 05:00:00 +0100 1553843 http://www.medworm.com/index.php?rid=1553842&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18367853%26dopt%3DAbstract Authors: Han CJ Despite recent developments in various chemotherapeutic agents and the performing of numerous clinical trials, chemotherapy still produces unsatisfactory results in hepatocellular carcinoma due to poor clinical benefit compared with untreated controls and its significant toxicity. The presence of liver cirrhosis, its complications, and decreased liver function increase the complexity of chemotherapy. There is recent evidence that targeted agents and antiangiogenic agents such as thalidomide are somewhat effective whilst having minimal toxicities. Some patients are cured by aggressive chemotherapy alone or in combination with other modalities. Therefore, if a patient is in good condition and the tumor shows some response to chemotherapy, aggressive chemotherapy might be ... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1553842 Sat, 01 Mar 2008 05:00:00 +0100 1553842 http://www.medworm.com/index.php?rid=1553841&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18367854%26dopt%3DAbstract Authors: Park SH Nonalcoholic fatty liver disease (NAFLD) is characterized by a wide spectrum of liver damage spanning steatosis, nonalcoholic steatohepatitis (NASH), cryptogenic liver cirrhosis, and even to hepatocellular carcinoma. Investigations in the last few years have focused on NASH, a relatively aggressive form of liver disease, due largely to the explosion of information provided by clinical and basic science studies related to the widespread presence of risk factors, such as obesity, type II diabetes mellitus, and dyslipidemia. This is especially important given that obesity and type II diabetes mellitus have recently reached epidemic proportions in Korea. The pathogenesis of NASH is multifactorial, with insulin resistance and increased fatty acid possibly being important fa... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1553841 Sat, 01 Mar 2008 05:00:00 +0100 1553841 http://www.medworm.com/index.php?rid=1553840&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18367855%26dopt%3DAbstract CONCLUSIONS: HCV genotype 2a is most common in Jeju, followed by genotype 1b. Our results suggest that the distribution of the HCV genotype differs between regions in Korea. PMID: 18367855 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1553840 Sat, 01 Mar 2008 05:00:00 +0100 1553840 http://www.medworm.com/index.php?rid=1553839&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18367856%26dopt%3DAbstract CONCLUSIONS: This study shows that a combination therapy of peginterferon and ribavirin is highly effective for chronic HCV infection, producing a high SVR and ETR. PMID: 18367856 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1553839 Sat, 01 Mar 2008 05:00:00 +0100 1553839 http://www.medworm.com/index.php?rid=1553838&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18367857%26dopt%3DAbstract CONCLUSIONS: The rate of SVRs in Korean patients with chronic hepatitis C was higher for combined PEG-IFN and ribavirin than for combined IFN-alpha and ribavirin. Further study is needed to clarify the outcome of short-term therapy in patients with a rapid or early virological response. PMID: 18367857 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1553838 Sat, 01 Mar 2008 05:00:00 +0100 1553838 http://www.medworm.com/index.php?rid=1553837&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18367858%26dopt%3DAbstract CONCLUSIONS: Lamivudine-resistant HBV patients exhibiting HBeAg negativity and liver cirrhosis were more likely to achieve an IVR after adefovir therapy. Adefovir resistance was associated with mixed infection of the precore mutant. PMID: 18367858 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1553837 Sat, 01 Mar 2008 05:00:00 +0100 1553837 http://www.medworm.com/index.php?rid=1553836&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18367859%26dopt%3DAbstract CONCLUSIONS: Anti-HBc positivity is not a risk factor for HCC. However, occult HBV infection may be a risk factor for HCC in patients with alcoholic LC. PMID: 18367859 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1553836 Sat, 01 Mar 2008 05:00:00 +0100 1553836 http://www.medworm.com/index.php?rid=1553835&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18367860%26dopt%3DAbstract CONCLUSIONS: Patients with NAFLD are at a high risk of carotid atherosclerosis regardless of metabolic syndrome and classical cardiovascular risk factors. Therefore, the detection of NAFLD should alert to the existence of an increased cardiovascular risk. Moreover, NAFLD might be an independent risk factor for cardiovascular disease. PMID: 18367860 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1553835 Sat, 01 Mar 2008 05:00:00 +0100 1553835 http://www.medworm.com/index.php?rid=1553834&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18367862%26dopt%3DAbstract Authors: Yoon JY, Min SY, Park JY, Hong SG, Park SJ, Paik SY, Park YM Allopurinol-induced hypersensitivity syndrome is characterized by an idiosyncratic reaction involving multiple-organs, which usually begins 2 to 6 weeks after starting allopurinol. In rare cases, the adverse reactions to allopurinol are accompanied by a variety of liver injury, such as reactive hepatitis, granulomatous hepatitis, vanishing bile duct syndrome, or fulminant hepatic failure. Here we report a case with granulomatous hepatitis and ductopenia. A 69-year-old man with chronic renal failure, hyperuricemia, and previously normal liver function presented with jaundice, skin rash, and fever 2 weeks after taking allopurinol (200 mg/day). In histopathology, a liver biopsy specimen showed mild spotty necrosis of he... Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1553834 Sat, 01 Mar 2008 05:00:00 +0100 1553834 http://www.medworm.com/index.php?rid=1553833&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18367863%26dopt%3DAbstract Authors: Lee JY, Park EB, Ahn JH, Suh SJ, Jung YK, Kim JH, Shin BK, Yang JH, Yeon JE, Byun KS Ticlopidine inhibits platelet aggregation and provides beneficial secondary prevention of cerebrovascular and coronary artery disease. Frequently reported adverse effects of ticlopidine include diarrhea, nausea, and rash. However, to our knowledge, there are only a few published reports of the simultaneous occurrence of cholestatic hepatitis and pure red cell aplasia. Here we report a patient with simultaneous severe cholestatic hepatitis and pure red cell aplasia associated with ticlopidine. Although these adverse effects are rare, periodic hematological and liver function tests are recommended after starting ticlopidine. PMID: 18367863 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1553833 Sat, 01 Mar 2008 05:00:00 +0100 1553833 http://www.medworm.com/index.php?rid=1553832&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18367864%26dopt%3DAbstract Authors: Kwon JE, Park YN PMID: 18367864 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1553832 Sat, 01 Mar 2008 05:00:00 +0100 1553832 http://www.medworm.com/index.php?rid=1553831&cid=s_30410_17_f&fid=30410&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18367865%26dopt%3DAbstract Authors: Lee WJ PMID: 18367865 [PubMed - in process] (Source: Korean J Hepatol) Korean J Hepatol journals http://www.medworm.com/rss/comments.php?id=1553831 Sat, 01 Mar 2008 05:00:00 +0100 1553831