MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Lipids in Health and Disease' source. Tue, 07 Feb 2012 05:19:55 +0100 http://www.medworm.com/index.php?rid=5664992&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F20 Sterol regulatory element binding protein- 1 and -2 (SREBP-1 and -2) are key transcription factors involved in the biosynthesis of cholesterol and fatty acids. The SREBP have mostly been studied in rodents in which lipogenesis is regulated in both liver and adipose tissue. There is, though, a paucity of information on birds, in which lipogenesis occurs essentially in the liver as in humans. Since a prelude to the investigation of the role of SREBP in lipid metabolism regulation in chicken, we review Size and Tissue expression Pattern of SREBP and role of this protein in chickens. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5664992 Mon, 06 Feb 2012 05:00:00 +0100 5664992 http://www.medworm.com/index.php?rid=5657678&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F19 Conclusions: The positive associations between the DIs and measures of adiposity (BMI and percent body fat) support increased desaturase activity in obesity. The lower vaccenic/stearic DI in DD SAT compared with Controls suggests presence of other factors involved in fat accumulation in addition to lifestyle. Other mechanisms driving fat accumulation in DD such as inflammation or lymphatic dysfunction should be investigated. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5657678 Fri, 03 Feb 2012 05:00:00 +0100 5657678 http://www.medworm.com/index.php?rid=5657679&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F18 Background: A considerable number of patients with severely elevated LDL-C do not achieve recommended treatment targets, despite treatment with statins. Adults at high cardiovascular risk with hypercholesterolemia and LDL-C [greater than or equal to]2.59 and [less than or equal to]4.14 mmol/L (N = 250), pretreated with atorvastatin 20 mg were randomized to ezetimibe/simvastatin 10/40 mg or atorvastatin 40 mg for 6 weeks. The percent change in LDL-C and other lipids was assessed using a constrained longitudinal data analysis method with terms for treatment, time, time-by-treatment interaction, stratum, and time-by-stratum interaction. Percentage of subjects achieving LDL-C (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5657679 Tue, 31 Jan 2012 05:00:00 +0100 5657679 http://www.medworm.com/index.php?rid=5657680&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F17 Background: Obesity is known to be associated with higher risks of cardiovascular disease, metabolic syndrome, and diabetes mellitus. Thyroid-stimulating hormone (TSHR) is the receptor for thyroid-stimulating hormone (TSH, or thyrotropin), the key regulator of thyroid functions. The expression of TSHR, once considered to be limited to thyrocytes, has been so far detected in many extrathyroidal tissues including liver and fat. Previous studies have shown that TSHR expression is upregulated when preadipocytes differentiate into mature adipocytes, suggestive of a possible role of TSHR in adipogenesis. However, it remains unclear whether TSHR expression in adipocytes is implicated in the pathogenesis of obesity. Methods: In the present study, TSHR expression in adipose tissues from both mice a... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5657680 Mon, 30 Jan 2012 05:00:00 +0100 5657680 http://www.medworm.com/index.php?rid=5657681&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F16 Conclusion: Aluminium-induced LPO in brain could arise from alteration of lipid metabolism particularly altered lipoprotein metabolism rather than a direct effect of cholesterol oxidation. Fenugreek seeds could play an anti-peroxidative role in brain which may be attributed in part to its modulatory effect on plasmatic lipid metabolism. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5657681 Thu, 26 Jan 2012 05:00:00 +0100 5657681 http://www.medworm.com/index.php?rid=5625962&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F15 Conclusions: Dietary n-3 PUFA enrichment may improve the immune response and IBD resistance, but the optimum performance does not coincide with the optimum immune response. It seems that dietary n-3 PUFA modulates the broiler chicken performance and immune response in a dose-dependent manner. Thus, a moderate level of dietary n-3 PUFA enrichment may help to put together the efficiency of performance and relative immune response enhancement in broiler chickens. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5625962 Wed, 25 Jan 2012 05:00:00 +0100 5625962 http://www.medworm.com/index.php?rid=5625963&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F14 Conclusions: The torque%, viscosity (cp) and SS (dyne/cm2) of all GNP sizes decreased with increasing the temperature and with decreasing the GNP size (for each fixed temperature value). For each shear rate value, the viscosity of all GNPs decreased with decreasing the GNP size. This study demonstrates that the physical, dimensional and morphological changes of GNPs have effective influence on their rheological properties. To understand and categorize the role of GNPs in drug delivery and cancer therapy, GNPs of varying size, number of particles, shape and surface should be taken into consideration. Moreover, further additional in vivo studies after administration of GNPs in rats should be performed to support this hypothesis. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5625963 Tue, 24 Jan 2012 05:00:00 +0100 5625963 http://www.medworm.com/index.php?rid=5617992&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F13 Conclusion: These results open up potential applications to use medium tyrosyl derivatives surfactants, antioxidants, antimicrobial and antileishmanial compounds in cosmetic, food and pharmaceutical industries. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5617992 Fri, 20 Jan 2012 05:00:00 +0100 5617992 http://www.medworm.com/index.php?rid=5605432&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F12 Background: It is well known that pulmonary alveolar proteinosis(PAP) is characterised by accumulation of surfactant lipids and proteins within airspaces. However, few previous data describe the serum lipid levels associated with PAP.Materials and methods: We retrospectively reviewed 25 patients with idiopathic PAP(iPAP). The serum lipid levels of patients with idiopathic PAP were compared with those of the healthy volunteers. In patients and healthy subjects, the LDL-C/HDL-C ratios were 2.94+/-1.21 and 1.60+/-0.70, respectively (p (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5605432 Tue, 17 Jan 2012 05:00:00 +0100 5605432 http://www.medworm.com/index.php?rid=5594778&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F9 Conclusions: The present study shows that the C allele carriers of ACAT-1 rs1044925 SNP in male hyperlipidemic subjects had higher serum TC, HDL-C and ApoAI levels than the C allele noncarriers. There is a sex (male)-specific association of ACAT-1 rs1044925 SNP and serum HDL-C and ApoAI levels in the hypercholesterolemic subjects. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5594778 Fri, 13 Jan 2012 05:00:00 +0100 5594778 http://www.medworm.com/index.php?rid=5594777&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F10 Conclusion: This study demonstrates that Cy-3-g regulates hepatic lipid homeostasis via an AMPK-dependent signaling pathway. Targeting AMPK activation by anthocyanin may represent a promising approach for the prevention and treatment of obesity-related nonalcoholic fatty liver disease. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5594777 Fri, 13 Jan 2012 05:00:00 +0100 5594777 http://www.medworm.com/index.php?rid=5594776&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F11 Conclusion: The results of our study indicate that conglycinin has effects comparable to fenofibrate and rosuvastatin on the control of plasma cholesterol, HDL-C and triacylglycerides, when given to hypercholesterolemic rats, and suggests that the association of this protein with rosuvastatin alters the action of drug in the homeostasis of cholesterol. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5594776 Fri, 13 Jan 2012 05:00:00 +0100 5594776 http://www.medworm.com/index.php?rid=5594779&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F8 Conclusions: Acute treatment with E.O. before BCCAO/R elicits changes both in the frontal cortex, where the BCCAO/R-induced decrease of DHA is apparently prevented and COX-2 expression decreases, and in plasma, where PEA and OEA levels and DHA biosynthesis increase. It is suggested that the increase of PEA and OEA plasma levels may induce DHA biosynthesis via peroxisome proliferator-activated receptor (PPAR) alpha activation, protecting brain tissue from ischemia/reperfusion injury. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5594779 Thu, 12 Jan 2012 05:00:00 +0100 5594779 http://www.medworm.com/index.php?rid=5594780&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F7 In conclusion, leucine supplementation combined with RE, but not isolated, improved the plasma lipid profile of dexamethasone-induced dyslipidemic rats. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5594780 Wed, 11 Jan 2012 05:00:00 +0100 5594780 http://www.medworm.com/index.php?rid=5578281&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F5 This study tests the hypothesis that treatment with fish oil will attenuate inflammatory responses and stabilize hemodynamics. Methods: Male SD rats (n = 48; 250~300 g) were randomly divided into 4 groups: SHAM, hemorrhagic shock (HS), hemorrhagic shock/resuscitation (HS/R) and fish oil (FO). Shock was induced, and a mean arterial pressure (MAP) was maintained at 35 to 40 mmHg for 60 minutes. Resuscitation was carried out by returning half of the shed blood and Ringer's lactate solution to the animal. In FO group, fish oil (0.2g/Kg) was infused through caudal vena at 30 minutes after shock. Half of each group was killed at 30 minutes and at 4 hours after resuscitation. Then several kinds of inflammation and oxidative stress indicators such as IL-6, MPO and GSH were tested.Result: FO group ... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5578281 Tue, 10 Jan 2012 05:00:00 +0100 5578281 http://www.medworm.com/index.php?rid=5578280&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F6 Conclusions: These data indicate that the vasodilator effect of the plant extract is mediated through multiple pathways like inhibition of Ca++ influx via membranous Ca++ channels, its release from intracellular stores and NO-mediated pathways, which possibly explain the fall in BP. The plant also showed reduction in body weight and antidyslipidemic effect which may be due to the inhibition of synthesis and absorption of lipids and antioxidant activities. Thus, this study provides a pharmacologic rationale to the medicinal use of Viola odorata in hypertension and dyslipidemia. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5578280 Tue, 10 Jan 2012 05:00:00 +0100 5578280 http://www.medworm.com/index.php?rid=5578282&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F4 Conclusion: The susceptibility of LDL to oxidation was a significant parameter that could predict new carotid artery atherosclerosis over a 5-year period, and higher susceptibility was associated with a higher incidence of new carotid artery atherosclerosis. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5578282 Mon, 09 Jan 2012 05:00:00 +0100 5578282 http://www.medworm.com/index.php?rid=5570315&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F1 Conclusions: The results suggest that linoleic acid promotes cell apoptosis through the release of cytochrome C, only if the intracellular calcium flux is unperturbed and intact. These results confirm that ER stress contributes to fatty acid-induced liver cell apoptosis. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5570315 Thu, 05 Jan 2012 05:00:00 +0100 5570315 http://www.medworm.com/index.php?rid=5570314&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F2 Conclusion Therefore, differences in the amount of carbohydrates and calories provided by the diet can lead to important metabolic disorders, such as impaired tolerance and accumulation of hepatic fat, and dietary restriction improves serum and tissue lipid profiles in laboratory animals. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5570314 Thu, 05 Jan 2012 05:00:00 +0100 5570314 http://www.medworm.com/index.php?rid=5570313&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F11%2F1%2F3 This article gives a summary of the most common therapeutic uses of dietary PLs to provide an overview of their approved and proposed benefits; and to identify further investigational needs.From the majority of the studies it became evident that dietary PLs have a positive impact in several diseases, apparently without severe side effects. Furthermore, they were shown to reduce side effects of some drugs. Both effects can partially be explained by the fact that PL are highly effective in delivering their fatty acid (FA) residues for incorporation into the membranes of cells involved in different diseases, e.g. immune or cancer cells. The altered membrane composition is assumed to have effects on the activity of membrane proteins (e.g. receptors) by affecting the microstructure of membranes... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5570313 Thu, 05 Jan 2012 05:00:00 +0100 5570313 http://www.medworm.com/index.php?rid=5557340&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F246 Conclusions: The present study provided the evidence for the protective role of PPARalpha in ameliorating ethanol induced liver injury through modulation of the genes related to lipid metabolism and inflammatory response. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5557340 Fri, 30 Dec 2011 05:00:00 +0100 5557340 http://www.medworm.com/index.php?rid=5557339&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F247 Conclusions: Fetal blood fatty acid composition essentially depends on and is altered by the maternal fatty acid supply. However, in addition to dietary factors, other aspects also contribute to the individual fatty acid distribution (oxidation, conversion, incorporation). The lower portion of fetal t11 compared to maternal t11, possibly results from delta-9-desaturation to c9,t11 CLA and/or oxidation. Based on the fatty acid distribution, it can be concluded that t11 differs from t9 regarding its metabolism and their impact on fetal LC-PUFA. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5557339 Fri, 30 Dec 2011 05:00:00 +0100 5557339 http://www.medworm.com/index.php?rid=5550629&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F244 This study systemic analysis the total genomic difference of gene expression between fat-1 transgenic cattle and wild-type using cDNA microarrays, several genes were found to be overexpressed or suppressed in transgenic cattle relative to wild-type, these discrepancy genes related with lipid metabolism, immunity, inflammation nervous development and fertility. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5550629 Thu, 29 Dec 2011 05:00:00 +0100 5550629 http://www.medworm.com/index.php?rid=5550628&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F245 Conclusions: Supplement with KO leads to a proportional increase of n-3 PUFA in myocardial tissue and supplement given before induction of MI attenuates LV remodeling. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5550628 Thu, 29 Dec 2011 05:00:00 +0100 5550628 http://www.medworm.com/index.php?rid=5550630&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F243 The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q, dolichols and isoprenoids. These molecules are required in the cell for functions ranging from signaling to membrane integrity, protein prenylation and glycosylation, and energy homeostasis. The pathway consists of a main trunk followed by sub-branches that synthesize the different biomolecules. The majority of our knowledge about the mevalonate pathway is currently focused on the cholesterol synthesis branch, which is the target of the cholesterol-lowering statins; less is known about the function and regulation of the non-cholesterol-related branches. To study them, we need a biological system where it is possible to specifically modulate these metabolic br... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5550630 Wed, 28 Dec 2011 05:00:00 +0100 5550630 http://www.medworm.com/index.php?rid=5535138&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F242 Conclusions: These results suggest that the great majority of our study populations are beneficial from alcohol consumption. But there is no interaction between the PPARD +294T>C genotypes and alcohol consumption on serum lipid levels in the drinkers. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5535138 Fri, 23 Dec 2011 05:00:00 +0100 5535138 http://www.medworm.com/index.php?rid=5535139&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F241 Conclusion: These results indicate that ARA supplementation, even at a relatively high dose, does not increase ARA metabolites, and suggest that it does not induce cardiovascular, inflammatory or allergic diseases in Japanese elderly individuals. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5535139 Thu, 22 Dec 2011 05:00:00 +0100 5535139 http://www.medworm.com/index.php?rid=5535140&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F240 Conclusion: These results suggest that fenugreek inhibited lipid accumulation in the liver by increasing the lipid excretion in the feces. The effective, safe and tolerable dose of fenugreek was found to be around 2.50 % (w/w). (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5535140 Wed, 21 Dec 2011 05:00:00 +0100 5535140 http://www.medworm.com/index.php?rid=5521620&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F238 Conclusions: Neoplastic status is a critical determinant of BAT activity in patients living in the tropics. More active neoplastic status was associated with more vigorous TMA of BAT. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5521620 Tue, 20 Dec 2011 05:00:00 +0100 5521620 http://www.medworm.com/index.php?rid=5521619&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F239 Conclusions: The present results demonstrated that quercetin and delta-tocotrienols inhibit the LPS-induced NO production in vivo. The microarray DNA analyses, followed by pathway analyses indicated that quercetin or delta-tocotrienol inhibit several LPS-induced expression of several ageing and pro-inflammatory genes (IL-1beta, IL-1alpha, IL-6, TNF-alpha, IL-12, iNOS, VCAM1, ICAM1, COX2, IL-1RA, TRAF1 and CD40). The NF-kappaB pathway regulates the production of NO and inhibits the pro-inflammatory cytokines involved in normal and ageing process. These ex vivo results confirmed the earlier in vitro findings. The present findings of inhibition of NO production by quercetin and delta-tocotrienol may be of clinical significance treating several inflammatory diseases, including ageing process. ... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5521619 Tue, 20 Dec 2011 05:00:00 +0100 5521619 http://www.medworm.com/index.php?rid=5521621&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F237 Background The presence of smaller low-density lipoproteins (LDL) has been associated with atherosclerosis risk, and the insulin resistance (IR) underlying the metabolic syndrome (MetS). In addition, some research has supported the association of very low-, low- and high-density lipoprotein (VLDL HDL) particle diameters with components of the metabolic syndrome (MetS), although this has been the focus of less research. We aimed to explore the relationship of VLDL, LDL and HDL diameters to MetS and its features, and by clustering individuals by their diameters of VLDL, LDL and HDL particles, to capture information across all three fractions of lipoprotein into a unified phenotype.Methods We used nuclear magnetic resonance spectroscopy measurements on fasting plasma samples from a general po... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5521621 Mon, 19 Dec 2011 05:00:00 +0100 5521621 http://www.medworm.com/index.php?rid=5513505&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F236 Conclusions: Taken together, our data suggests that TQ could potentially be applied toward the treatment of MM and other malignancies. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5513505 Fri, 16 Dec 2011 05:00:00 +0100 5513505 http://www.medworm.com/index.php?rid=5502493&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F234 Conclusion: These data are consistent with the hypothesis that fatty acids are deranged in mice with non-alcoholic fatty liver injury induced by high-fat feed and CCl4, which may be involved in its pathogenesis and/or progression via an unclear mechanism. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5502493 Wed, 14 Dec 2011 05:00:00 +0100 5502493 http://www.medworm.com/index.php?rid=5502492&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F235 Conclusion: In conclusion, dietary supplementation with WP enhances the normal inflammatory responses during wound healing in diabetic mice by restoring the levels of oxidative stress and inflammatory cytokines. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5502492 Wed, 14 Dec 2011 05:00:00 +0100 5502492 http://www.medworm.com/index.php?rid=5493228&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F232 Conclusion: Oxidative damage may be an initiating event and contributes, in part, to the mechanism of toxicity of Pelagia noctiluca venom. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5493228 Fri, 09 Dec 2011 05:00:00 +0100 5493228 http://www.medworm.com/index.php?rid=5493227&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F233 Conclusions: The alterations induced by intraperitoneal administration of GNPs were size-dependent, with smaller ones inducing greater affects, and were also related to the time exposure to GNPs. These alterations may indicate scattered cytoplasmic vacuolization, which may induce the toxicity effect through an inability to deal with the accumulated residues resulting from metabolic and structural disturbances caused by these NPs. These histological alterations were more prominent with 10 nm size particles than with the larger ones. The interaction of GNPs with proteins and various cell types should be considered as part of the toxicological evaluation. Additional experiments related to plasma, tissues cytokine, antioxidant defense mechanism, lipid peroxidation, histomorphologcal and ultras... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5493227 Fri, 09 Dec 2011 05:00:00 +0100 5493227 http://www.medworm.com/index.php?rid=5484589&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F231 Conclusion: LDKT is generally regarded as beneficial for allograft recipients and not particularly detrimental for the donors. However, it could be demonstrated in this study that a moderate reduction of kidney function by unilateral nephrectomy, resulted in an imbalance of components of vitamin A metabolism with a significant increase of retinol and RBP4 and apoRBP4 concentration in serum of donors. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5484589 Wed, 07 Dec 2011 05:00:00 +0100 5484589 http://www.medworm.com/index.php?rid=5484592&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F228 Conclusion: AGEs seem to be a good biomarker to evaluate the association between diabetes and atherosclerotic disorders in aging diabetes. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5484592 Tue, 06 Dec 2011 05:00:00 +0100 5484592 http://www.medworm.com/index.php?rid=5484591&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F229 Background: In obesity, phenotypic switches occur in macrophage populations such that the predominantly M2-polarised anti-inflammatory state seen in lean individuals changes to a predominantly M1-polarised pro-inflammatory state in those who are obese. However, the mechanisms by which these phenotypic shifts occur have not yet been fully elucidated. Results: The effects of oxLDL (1-40ug/ml; 24h) on several parameters relevant to the Unfolded Protein Response (UPR)-mediated lipotoxic effects of oxLDL (disruption of ER Ca2+ handling; activation of the UPR transcription factor XBP-1; upregulation of the UPR target genes BiP and CHOP; apoptosis; cell viability) were investigated in human primary monocyte-derived macrophages, and also in monocyte-macrophages derived from the THP-1 monocytic cel... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5484591 Tue, 06 Dec 2011 05:00:00 +0100 5484591 http://www.medworm.com/index.php?rid=5484590&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F230 Conclusions: The associations of TRIB1 rs17321515 SNP and serum lipid levels are different between the Mulao and Han populations. These discrepancies might partly result from different TRIB1 gene-environmental interactions in both ethnic groups. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5484590 Tue, 06 Dec 2011 05:00:00 +0100 5484590 http://www.medworm.com/index.php?rid=5474464&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F226 Conclusion: overall, the findings of the current study indicate that this formulation Om3/terp exhibit attractive properties and can, therefore, be considered for future application in the development of anti-diabetic, anti-hypertensive and hypolipidemic foods. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5474464 Mon, 05 Dec 2011 05:00:00 +0100 5474464 http://www.medworm.com/index.php?rid=5474463&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F227 Conclusions: Our data demonstrate that PPI-1011, an ether lipid precursor of plasmalogens is orally bioavailable in the rabbit, augmenting the circulating levels of unesterified DHA and DHA-containing PlsEtn and PtdEtn. Other ethanolamine plasmalogens were generated from the precursor via lipid remodeling (de-acylation/re-acylation reactions at sn-2) and phosphatidylethanolamines were generated via de-alkylation/re-acylation reactions at sn-1. Repeated oral dosing for 2 weeks with PPI-1011 resulted in dose-dependent increases in circulating DHA and DHA-containing plasmalogens. These products and/or precursors were also able to cross the blood-retinal and blood-brain barriers. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5474463 Mon, 05 Dec 2011 05:00:00 +0100 5474463 http://www.medworm.com/index.php?rid=5466551&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F225 IntroductionEndurance exercise is known to promote a substantial effect on the energy balance in rats and humans. However, little is known about the exact mechanisms for the appetite-suppressive effects of endurance exercise. We hypothesized that endurance training might activate signaling cascades in the hypothalamus known to be involved in leptin signaling. Methods: 16 male Wistar rats were randomly assigned to two groups: sedentary (n=8) and exercise groups (n=8). Animals in the exercise group started treadmill running at 30 m/min, 0% grade, for 1 min/bout. Running time was gradually increased by 2 min/bout every day. The training plan was one bout per day during initial two weeks, and two bouts per day during 3rd-9th week. At the end of nine-week experiment, blood was analyzed for low-... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5466551 Fri, 02 Dec 2011 05:00:00 +0100 5466551 http://www.medworm.com/index.php?rid=5466554&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F222 Conclusion: 13-HODE induces cholesterol efflux from macrophages via the PPAR-LXRalpha-ABCA1/SR-BI-pathway. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5466554 Wed, 30 Nov 2011 05:00:00 +0100 5466554 http://www.medworm.com/index.php?rid=5466553&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F223 Conclusions: Activity intensity related beneficially to blood lipids in almost every ethnic group. The activity duration was unrelated to blood lipids, while the total PA 'summary score' was associated only with blood lipids for African-Surinamese. The difference in total PA composition is the most probable explanation for ethnic differences in the total PA association with blood lipids. Multi-ethnic observational studies should include not only a measure of the total PA, but other measures of PA as well, particularly the intensity of activity. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5466553 Wed, 30 Nov 2011 05:00:00 +0100 5466553 http://www.medworm.com/index.php?rid=5466552&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F224 This study aimed to compare the anti-inflammatory effects of ETC-642, an apoA-I mimetic peptide, with that of discoidal reconstituted HDL (rHDL), consisting of full-length apoA-I complexed with phosphatidylcholine, in rabbits with chronic vascular inflammation. Results: New Zealand White rabbits (n=10/group) were placed on chow supplemented with 0.2% (w/w) cholesterol for 6-weeks. The animals received two infusions of saline, rHDL (8mg/kg apoA-I) or ETC-642 (30 mg/kg peptide) on the third and fifth days of the final week. The infusions of rHDL and ETC-642 were able to significantly reduce cholesterol-induced expression of intracellular cell adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in the thoracic aorta (p (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5466552 Wed, 30 Nov 2011 05:00:00 +0100 5466552 http://www.medworm.com/index.php?rid=5455098&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F221 Conclusions: These properties added to the high activity in high alkaline pH make this novel lipase an ideal choice for application in detergent formulations. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5455098 Mon, 28 Nov 2011 05:00:00 +0100 5455098 http://www.medworm.com/index.php?rid=5448303&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F220 Background: Aging and dyslipidemia are processes which can lead to deleterious consequences to renal function. Therefore, the aim of this study was to determine the effects of both hypercholesterolemia and aging on renal function in mice. Methods: Male hypercholesterolemic apolipoprotein E-deficient mice (ApoE, n=13) and age-matched C57BL/6 control mice (C57, n=15) were studied at 2 (young) and 8 (adult) month-old. At each time point, animals were placed in metabolic cages for 24 hours to urine volume and urinary creatinine quantification. Blood samples were collected for serum cholesterol, urea and creatinine measurements. Glomerular filtration rate (GFR) was estimated through creatinine clearance determination. Mesangial expansion was evaluated by Periodic Acid Schiff staining, renal fib... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5448303 Sat, 26 Nov 2011 05:00:00 +0100 5448303 http://www.medworm.com/index.php?rid=5448304&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F218 This study is the first to assess the effects of oleic, linoleic or palmitic acids on protein expression of fibroblasts, as determined by standard proteomic techniques. The fatty acids were not cytotoxic at the concentration used in this work as assessed by membrane integrity, DNA fragmentation and the MTT assay but significantly increased cell proliferation. Subsequently, a proteomic analysis was performed using two dimensional difference gel electrophoresis (2D-DIGE) and MS based identification. Cells treated with 50 microM oleic, linoleic or palmitic acid for 24 h were associated with 24, 22, 16 spots differentially expressed, respectively. Among the identified proteins, alpha-enolase and far upstream element binding protein 1 (FBP-1) are of importance due to their function in fibroblas... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5448304 Thu, 24 Nov 2011 05:00:00 +0100 5448304 http://www.medworm.com/index.php?rid=5438606&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F217 Obese subjects with impaired glucose tolerance (IGT) are more susceptible than healthy individuals to oxidative stress and cardiovascular disease. This randomised controlled investigation was designed to test the hypothesis that alpha-lipoic acid supplementation and exercise training may elicit favourable clinical changes in obese subjects with IGT. All data were collected from 24 obese (BMI [greater than or equal to] 30 kg/m2) IGT patients. Following participant randomisation into two groups, fasting venous blood samples were obtained at baseline, and before and following intervention. The first group consisted of 12 participants who completed a 12 week control phase followed by 12 weeks of chronic exercise at 65% HRmax for 30 minutes a day, 5 days per week, while ingesting 1 gram per day... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5438606 Tue, 22 Nov 2011 05:00:00 +0100 5438606 http://www.medworm.com/index.php?rid=5438607&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F216 Background: Oxidized low density lipoprotein plays an important role in development of foam cells in atherosclerosis. The study was focused on regulation of primary human monocyte growth and CD11b expression in presence of Nigella sativa oil. Methods: Primary human monocytes were isolated from whole blood and grown at 37 degree C and 5%CO2 saturation for five days prior to treatment with Nigella sativa oil. The cells were plated and washed before treatment with ox-LDL (10 microgram/ml) as positive control and combined treatment of ox-LDL (10 microgram/ml) and (140ng/ml) Nigella sativa oil. The growth progression was monitored every 24 hours for 3 days. Results: Macrophages showed reduced growth in comparison to monocytes 24 hours after treatment with Nigella sativa oil. The mean cell diame... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5438607 Mon, 21 Nov 2011 05:00:00 +0100 5438607 http://www.medworm.com/index.php?rid=5419425&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F212 Background: Fibrates have been reported to cause paradoxical decreases in HDL-C in certain patients.Design and methods: This post-hoc analysis explored the frequency/magnitude of HDL-C reductions in a pooled database of mixed dyslipidemic patients (LDL-C:3.4-5.7 mmol/L;TG:1.7-5.7 mmol/L) receiving placebo (PBO), fenofibrate (FENO), ezetimibe plus FENO (EZE+FENO), or EZE/simvastatin plus FENO (EZE/SIMVA+FENO) for 12 weeks. Results: PBO-treated patients had the highest incidence of HDL-C reductions from baseline (45%) compared with patients taking FENO (14%), EZE+FENO (9%), or EZE/SIMVA+FENO (9%). Reductions (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5419425 Wed, 16 Nov 2011 05:00:00 +0100 5419425 http://www.medworm.com/index.php?rid=5419424&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F213 In this study we investigated the effect of fish polar lipid consumption on PAF metabolism. Results: The specific activities of four PAF metabolic enzymes; in leukocytes, platelets and plasma, and PAF concentration; either in blood cells or plasma were determined. Samples were acquired at the beginning and at the end of a previously conducted study in male New Zealand white rabbits that were fed for 45 days with atherogenic diet supplemented (group-B, n=6) or not (group-A, n=6) with gilthead sea bream (Sparus aurata) polar lipids.The specific activity of PAF-Acetylhydrolase (PAF-AH); a catabolic enzyme of PAF, was decreased in rabbits' platelets of both A and B groups and in rabbits' leukocytes of group A (p (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5419424 Wed, 16 Nov 2011 05:00:00 +0100 5419424 http://www.medworm.com/index.php?rid=5419423&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F214 Conclusions: Our data demonstrate that ibuprofen, a drug known to reduce the risk of colorectal cancer, reduces cellular diamine levels via augmentation of diamine efflux. Similarly, augmentation of membrane plasmalogens can increase diamine export from control and plasmalogen-deficient cells. These data support the concept that membrane transporter function may be a therapeutic point of intervention for dietary and pharmacological approaches to cancer chemoprevention. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5419423 Wed, 16 Nov 2011 05:00:00 +0100 5419423 http://www.medworm.com/index.php?rid=5405144&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F211 Since the early 1990s, several strains of genetically modified mice have been developed as models for experimental atherosclerosis. Among the available models, the apolipoprotein E-deficient (apoE-/-) mouse is of particular relevance because of its propensity to spontaneously develop hypercholesterolemia and atherosclerotic lesions that are similar to those found in humans, even when the mice are fed a chow diet. The main purpose of this review is to highlight the key achievements that have contribute to elucidating the mechanisms pertaining to vascular dysfunction in the apoE-/- mouse. First, we summarize lipoproteins and atherosclerosis phenotypes in the apoE-/- mouse, and then we briefly discuss controversial evidence relative to the influence of gender on the development of atheroscler... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5405144 Mon, 14 Nov 2011 05:00:00 +0100 5405144 http://www.medworm.com/index.php?rid=5405145&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F210 Conclusion: Probucol alleviated atherosclerosis by improving HDL function. The mechanisms include accelerating the process of reverse cholesterol transport, improving the anti-inflammatory and anti-oxidant functions. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5405145 Sat, 12 Nov 2011 05:00:00 +0100 5405145 http://www.medworm.com/index.php?rid=5398156&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F207 Conclusion: HBV infection plays an inhibitory effect on apoB expression. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5398156 Fri, 11 Nov 2011 05:00:00 +0100 5398156 http://www.medworm.com/index.php?rid=5398155&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F208 Conclusions: This study indicates that the GNP size has considerable influence on the viscosity of GNPs. The strong dielectric dispersion was GNP size dependent. The decrease in relaxation time might be attributed to increase in the localized charges distribution within the medium confirmed by the conductivity data. This study suggests that further experiments are required to be done after the administration of GNPs through different routes in rats in vivo. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5398155 Fri, 11 Nov 2011 05:00:00 +0100 5398155 http://www.medworm.com/index.php?rid=5398154&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F209 Conclusion: A simultaneous biosurfactant and extracellular lipolytic enzymes produced bacterial strain with potential application in soap stock treatment (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5398154 Fri, 11 Nov 2011 05:00:00 +0100 5398154 http://www.medworm.com/index.php?rid=5398159&cid=s_29184_162_f&fid=29184&url=%24%7Bitem.link%7D Conclusion: Our results demonstrated the relationship between ulcerative colitis and obesity as aggravating factors for each disease, with increased inflammation in the colon and adipose tissue and systemic alterations observed in the spleen, lymph nodes and bloodstream. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5398159 Thu, 10 Nov 2011 05:00:00 +0100 5398159 http://www.medworm.com/index.php?rid=5398158&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F205 Conclusions: The histological alterations induced by intraperitoneal administration of GNPs were size-dependent with smaller ones induced more affects and related with time exposure of GNPs. This study suggests that interaction of GNPs with proteins and various cell types might be evaluated as part of the toxicological assessment in addition to further experiments related to tissues antioxidant enzymes, oxidative parameters, lipid peroxidation, production of free radicals and/or ROS and cytokine, histomorphologcal and ultrastrucural will be performed to cover and understand the toxicity and the potential use of GNPs as therapeutic and diagnostic tool. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5398158 Thu, 10 Nov 2011 05:00:00 +0100 5398158 http://www.medworm.com/index.php?rid=5398157&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F206 Background: Apolipoprotein E (apoE) is a key component of the lipid metabolism. Polymorphisms at the apoE gene (APOE) have been associated with cardiovascular disease, lipid levels and lipid-lowering response to statins. We evaluated the effects on APOE expression of hypercholesterolemia, APOE epsilon2/epsilon3/epsilon4 genotypes and atorvastatin treatment in Brazilian individuals. The relationship of APOE genotypes and plasma lipids and atorvastatin response was also tested in this population. Methods: APOE epsilon2/epsilon3/epsilon4 and plasma lipids were evaluated in 181 normolipidemic (NL) and 181 hypercholesterolemic (HC) subjects. HC individuals with indication for lowering-cholesterol treatment (n=141) were treated with atorvastatin (10 mg/day/4-weeks). APOE genotypes and APOE mRNA ... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5398157 Thu, 10 Nov 2011 05:00:00 +0100 5398157 http://www.medworm.com/index.php?rid=5398161&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F202 Conclusion: We speculate that the condensed tannins contained in lotus root can alleviate hepatic steatosis by suppressing the lipogenic enzyme activity in the livers of db/db mice. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5398161 Wed, 09 Nov 2011 05:00:00 +0100 5398161 http://www.medworm.com/index.php?rid=5398160&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F203 In this study, the effects of camel WP on the chemotaxis of B and T cells to CXCL12 and CCL21 in diabetic mice were investigated. Results: Flow cytometric analysis of the surface expressions of CXCR4 (CXCL12 receptor) and CCR7 (CCL21 receptor) on B and T cells revealed that the surface expressions of CXCR4 and CCR7 were not significantly altered in diabetic and WP-supplemented diabetic mice compared with control mice. Nevertheless, B and T lymphocytes from diabetic mice were found to be in a stunned state, with a marked and significant (P (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5398160 Wed, 09 Nov 2011 05:00:00 +0100 5398160 http://www.medworm.com/index.php?rid=5398162&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F201 Background: One of the well-defined and characterized protein modifications usually produced by oxidation is carbonylation, an irreversible non-enzymatic modification of proteins. However, carbonyl groups can be introduced into proteins by non-oxidative mechanisms. Reactive carbonyl compounds have been observed to have increased in patients with renal failure. In the present work we have described a procedure designed as aldehyde capture to calculate the protein carbonyl stress derived solely from lipid peroxidation. Methods: Acrolein-albumin adduct was prepared as standard at alkaline pH. Rat liver microsomal membranes and serum samples from patients with diabetic nephropathy were subjected to the aldehyde capture procedure and aldol-protein formation. Before alkalinization and incubation... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5398162 Mon, 07 Nov 2011 05:00:00 +0100 5398162 http://www.medworm.com/index.php?rid=5377923&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F199 Background: Apolipoprotein M (apoM) may have potential antiatherosclerotic properties. It has been reported that apoM expression could be regulated by many intracellar and extracellar factors. In the present study we further investigated regulation of apoM expression in Caco-2 cells stimulated by a liver X receptor (LXR) agonist, TO901317.Materials and Methods: Caco-2 cells were cultured in the presence of either TO901317, farnesoid X receptor (FXR) antagonist guggulsterone or TO901317 together with guggulsterone at different concentrations for 24 hrs. The mRNA levels of ATP-binding cassette transporter A1 (ABCA1), apoA1, apoM, liver receptor homologue-1 (LRH-1) and short heterodimer partner 1 (SHP1) were determined by real-time RT-PCR. Results: When Caco-2 cell cultured with TO901317 alon... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5377923 Fri, 04 Nov 2011 04:00:00 +0100 5377923 http://www.medworm.com/index.php?rid=5377922&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F200 Background: Several polymorphisms in the apolipoprotein C3 (APOC3) gene have been found association with hypertriglyceridemia(HTG), but the link with coronary heart disease(CHD) risk between ethnicities was still controversial. Among them, reseachers paid more attentions to the promoter polymorphisms T-455C and C-482T because both of them located in insulin-responsive element (IRE) and insulin was thought to exert its action by down-regulating APOC3 gene expression. The aim of this study was to investigate the association of the two polymorphisms of APOC3 with CHD in a Han population in East China. Methods: TaqMan SNP Genotyping Assays were carried out to detect the genotypes of APOC3 gene, including the T-455C and C-482T, in 286 subjects with CHD and 325 controls without CHD. The levels o... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5377922 Fri, 04 Nov 2011 04:00:00 +0100 5377922 http://www.medworm.com/index.php?rid=5377924&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F198 Conclusions: This study demonstrates that in mice with long-standing obesity diminished gene expression of several adipocytokines accompany apoptosis and reduced mass of the epididymal fat. Our findings suggest that this is due to both increased prevalence of dead adipocytes and altered immune cell activity. Differential distribution of metabolically challenged adipocytes is indicative of the presence of biologically diverse zones within the epididymal fat. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5377924 Thu, 03 Nov 2011 04:00:00 +0100 5377924 http://www.medworm.com/index.php?rid=5377925&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F197 Conclusions: The variation in lipid profile associated with the C-514T polymorphism is significant, and the T allele is associated with the best response to ERT. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5377925 Wed, 02 Nov 2011 04:00:00 +0100 5377925 http://www.medworm.com/index.php?rid=5377926&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F196 Conclusions: The substrate specificity is modulated by the fatty acid composition of the phosphatidylcholine used as well as by the presence of other charged phospholipids. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5377926 Tue, 01 Nov 2011 04:00:00 +0100 5377926 http://www.medworm.com/index.php?rid=5377927&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F195 Conclusions The fluorescence intensity of GNPs varied with the number, size and shape of particles and with the ratio of surface area to volume in a given sample. Fluorescence intensity changes during infusion depended on the size and shape of GNPs, with smaller particles experiencing larger changes during the infusion time in addition to the quenching produced by the larger GNPs. It is likely that smaller particles, which have a much higher ratio of surface area to volume compared to larger particles, are more prone to aggregation andsurface interaction with biological components. This study suggests that fluorescence intensity can be used to evaluate bioaccumulation and the toxicity of gold nanoparticles in rats. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5377927 Mon, 31 Oct 2011 04:00:00 +0100 5377927 http://www.medworm.com/index.php?rid=5377928&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F194 Background: Alterations of endocannabinoid system in adipose tissue play an important role in lipid regulation and metabolic dysfunction associated with obesity. The purpose of this study was to determine whether gene expression levels of cannabinoid type 1 receptor (CB1) and fatty acid amide hydrolase (FAAH) are different in subcutaneous abdominal and gluteal adipose tissue, and whether hypocaloric diet and aerobic exercise influence subcutaneous adipose tissue CB1 and FAAH gene expression in obese women. Methods: Thirty overweight or obese, middle-aged women (BMI=34.3+/-0.8 kg/m2, age= 59+/-1 years) underwent one of three 20-week weight loss interventions: caloric restriction only (CR, N=9), caloric restriction plus moderate-intensity aerobic exercise (CRM, 45-50% HRR, N=13), or caloric ... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5377928 Fri, 28 Oct 2011 04:00:00 +0100 5377928 http://www.medworm.com/index.php?rid=5356639&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F192 Conclusions: Lipid metabolism and autonomic functioning seem to be related to the discussed psychiatric disorders. LI, in addition, could represent a new possible biomarker to be considered. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5356639 Fri, 28 Oct 2011 04:00:00 +0100 5356639 http://www.medworm.com/index.php?rid=5356638&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F193 Conclusions: We found higher percentage of AA genotype and A allele of ABCA G2706A in PCOS patients compare to controls. The fasting insulin and homocystein levels were significantly higher in PCOS patients with ABCA G1051A mutant genotype than those with heterozygote and wild genotypes. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5356638 Fri, 28 Oct 2011 04:00:00 +0100 5356638 http://www.medworm.com/index.php?rid=5356640&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F191 Background: Blood viscosity appears to be independent predictor of stroke, carotid intima-media thickening, atherosclerosis and most cardiovascular diseases. In an attempt to understand the toxicity and the potential threat of GNPs therapeutic and diagnostic use, an array of rheological parameters were performed to quantify the blood plasma response to different sizes and administration periods of GNPs over a wide range of shear rates. Methods: Healthy, thirty male Wistar-Kyoto rats, 8-12 weeks old (approximately 250 g body weight) were divided into control group (NG: n = 10), group 1 (G1A: intraperitoneal infusion of 10 nm GNPs for 3 days, n = 5 and G1B: intraperitoneal infusion of 10 nm GNPs for 7 days, n = 5), group 2 (G2A: intraperitoneal infusion of 50 nm GNPs for 3 days, n = 5 and G2... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5356640 Thu, 27 Oct 2011 04:00:00 +0100 5356640 http://www.medworm.com/index.php?rid=5356642&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F189 Conclusions: We demonstrated that pollock oil supplementation effectively improved hyperlipidemia, attenuated hepatic steatosis, and downregulated the express of hepatic genes involved in cholesterol and lipid metabolism in mice with diet-induced obesity. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5356642 Tue, 25 Oct 2011 04:00:00 +0100 5356642 http://www.medworm.com/index.php?rid=5356641&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F190 Conclusion: We find that TTA-induced growth inhibition of SW620 cells seems to be mediated through induction of ER stress and activation of the UPR pathway. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5356641 Tue, 25 Oct 2011 04:00:00 +0100 5356641 http://www.medworm.com/index.php?rid=5344721&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F186 Background: The plasma lipoprotein response of F1B Golden-Syrian hamsters fed diets high in very long chain (VLC) n-3 polyunsaturated fatty acids (PUFA) is paradoxical to that observed in humans. This anomaly is attributed, in part, to low lipoprotein lipase activity and is dependent on cholesterol status. To further elucidate the mechanism(s) for these responses, hamsters were fed diets containing supplemental fish oil (VLC n-3 PUFA) or safflower oil (n-6 PUFA) (both 10% [w/w]) and either cholesterol-supplemented (0.1% cholesterol [w/w]) or cholesterol-depleted (0.01% cholesterol [w/w] and 10 days prior to killing fed 0.15% lovastatin+2% cholestyramine [w/w]). Results: Cholesterol-supplemented hamsters fed fish oil, relative to safflower oil, had higher non-high density lipoprotein (HDL) ... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5344721 Fri, 21 Oct 2011 04:00:00 +0100 5344721 http://www.medworm.com/index.php?rid=5344720&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F187 Conclusion We proposed a simplified mathematical model to simulate the reduction in LDL cholesterol after separate and combined intake of statins and functional foods acting on intestinal (re)absorption of cholesterol or bile acids in humans. In future work, this model can be extended to include more complex (regulatory) mechanisms. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5344720 Fri, 21 Oct 2011 04:00:00 +0100 5344720 http://www.medworm.com/index.php?rid=5332563&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F184 Conclusions: Dietary OO and BT produces similar liver microsomal fatty acid composition and may account for less severe liver injury after acetaminophen treatment compared to animals fed diets with CO rich in linoleic acid. These findings imply that types of dietary fat may be important in the nutritional management of drug-induced hepatotoxicity. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5332563 Thu, 20 Oct 2011 04:00:00 +0100 5332563 http://www.medworm.com/index.php?rid=5332562&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F185 Conclusions: In FH the MPO serum levels were modulated through changes in the TC concentrations carried out by LDL-A. Further study is needed to determine whether reduced MPO levels obtained by LDL-A could have any therapeutic impact. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5332562 Thu, 20 Oct 2011 04:00:00 +0100 5332562 http://www.medworm.com/index.php?rid=5332564&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F183 Background: The Visceral Adiposity Index (VAI) is a sex-specific mathematical index, based on Waist Circumference (WC), Body Mass Index (BMI), triglycerides (TG) and HDL cholesterol (HDL) levels, indirectly expressing visceral adipose function and insulin sensitivity. Our aim was to find the optimal cut-off points of VAI identifying a visceral adipose dysfunction (VAD) associated with cardiometabolic risk in a Caucasian Sicilian population. Methods: Medical check-up data of 1,764 Primary Care patients (PC patients) were retrospectively and cross-sectionally examined using a receiver-operating characteristic (ROC) curve to determine appropriate stratified-for-age cut-off of VAI, for the identification of PC patients with Metabolic Syndrome (MetS) according to the NCEP-ATP III criteria. The ... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5332564 Wed, 19 Oct 2011 04:00:00 +0100 5332564 http://www.medworm.com/index.php?rid=5332566&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F181 Conclusions: We have characterized the changes in LDL and VLDL particle number, and their subclass patterns following a high-fat meal. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5332566 Tue, 18 Oct 2011 04:00:00 +0100 5332566 http://www.medworm.com/index.php?rid=5332565&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F182 Conclusions: Our data demonstrate that PPI-1011 is activated (removal of 3-substitution) and converted to PlsEtn in vitro in both RCDP1 and RCDP2 lymphocytes and in vivo in the Pex7 mouse model of RCPD1 effectively bypassing the peroxisomal dysfunction present in these disorders. While PPI-1011 was shown to replete PlsEtns 16:0/x, ether lipid precursors of PlsEtn 18:0/x and PlsEtn 18:1/x may also be needed to achieve optimal clinical benefits of plasmalogen replacement in these complex patient populations. In contrast, only limited plasmalogen replacement was observed in PMD lymphocytes suggesting that the effects of protein misfolding and accumulation in the ER negatively affect processing of plasmalogen precursors in this cellular compartment. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5332565 Tue, 18 Oct 2011 04:00:00 +0100 5332565 http://www.medworm.com/index.php?rid=5322249&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F180 Conclusion: In conclusion, these results indicate that canola oil reduces antioxidant status and increases plasma lipids, which are risk factors for cardiovascular disease. However, canola oil in combination with salt intake increased MDA, a marker of lipid peroxidation and decreased NAPDH oxidase subunits and aortic SOD gene expression. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5322249 Mon, 17 Oct 2011 02:23:29 +0100 5322249 http://www.medworm.com/index.php?rid=5322251&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F178 Conclusions, Results of the presented study suggest that the addition of beetroot crisps could alleviate metabolic changes in dyslipidaemic diet-administered rats. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5322251 Fri, 14 Oct 2011 04:00:00 +0100 5322251 http://www.medworm.com/index.php?rid=5322250&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F179 Conclusions: On the basis that the optimal n-3 PUFA sources should provide high digestibility and efficient tissue incorporation with the least tissue lipid peroxidation, TO and SO appeared to be the most beneficial of the n-3 PUFAs sources evaluated in this study. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5322250 Fri, 14 Oct 2011 04:00:00 +0100 5322250 http://www.medworm.com/index.php?rid=5312090&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F176 This article will review recent advances in understanding of the potential mechanism of low HDL-C in obesity. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5312090 Wed, 12 Oct 2011 04:00:00 +0100 5312090 http://www.medworm.com/index.php?rid=5312089&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F177 Conclusions: Results of the current study demonstrate that delta-tocotrienol, riboflavin, and quercetin inhibit NO production by LPS-stimulated macrophages of all four strains of mice, and TNF-alpha secretion only by LPS-stimulated macrophages of C57BL/6 and BALB/c mice. The mechanism for this inhibition appears to be decreased proteolytic degradation of PI-kappaB protein by the inhibited proteasome, resulting in decreased translocation of activated NF-kappaB to the nucleus, and depressed transcription of gene expression of TNF-alpha, and iNOS. Further, these naturally-occurring proteasome inhibitors tested appear to be relatively potent inhibitors of multiple proteasome subunits in inflammatory proteasomes. Consequently, these agents could potentially suppress the production of inflammat... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5312089 Wed, 12 Oct 2011 04:00:00 +0100 5312089 http://www.medworm.com/index.php?rid=5302348&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F175 Epidemiologic studies indicate a strong inverse correlation between plasma levels of high-density lipoproteins (HDL) and cardiovascular disease (CVD). The most relevant cardioprotective mechanism mediated by HDL is thought to be reverse cholesterol transport (RCT). New insights in HDL biology and RCT have allowed the development of promising agents aimed to increase HDL function and promote atherosclerosis regression. In this regard, apo-AI analogs and CETP inhibitors dalcetrapib and anacetrapib have aroused a great interest and opened new expectations in the treatment of CVD. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5302348 Mon, 10 Oct 2011 04:00:00 +0100 5302348 http://www.medworm.com/index.php?rid=5282709&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F174 Conclusions: These results suggest that oxLp(a) may be more closely associated with accelerated carotid atherosclerosis, in comparison to Lp(a), in this population. This finding can be important for obtaining a better understanding of the different atherogenic roles played by oxLp(a) in comparison to Lp(a). (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5282709 Tue, 04 Oct 2011 04:00:00 +0100 5282709 http://www.medworm.com/index.php?rid=5270822&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F173 Conclusions: Our results highlight involvement of miRNAs in the induction of apoptosis in glioma cells by fatty acids and temozolomide. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5270822 Fri, 30 Sep 2011 04:00:00 +0100 5270822 http://www.medworm.com/index.php?rid=5270824&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F171 Conclusions: Taken together, these data are consistent with the notion that kidney sourced adipose stromal (KiSAS) cells may be primed to recreate a regenerative micro-environment within the kidney. These findings open the possibility of isolating solid-organ associated adipose derived cell populations for therapeutic applications in organ-specific regenerative medicine products. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5270824 Thu, 29 Sep 2011 04:00:00 +0100 5270824 http://www.medworm.com/index.php?rid=5270823&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F172 Conclusion: In macrophages overloaded with oxidized LDL, glycolaldehyde treatment reduces the HDL-mediated cholesterol and 7-ketocholesterol efflux which is ascribed to the reduction in ABCA-1 and ABCG-1 protein level. This may contribute to atherosclerosis in diabetes mellitus. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5270823 Thu, 29 Sep 2011 04:00:00 +0100 5270823 http://www.medworm.com/index.php?rid=5270825&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F170 The association of cardiovascular events with Lp-PLA2 has been studied continuously today. The enzyme has been strongly associated with several cardiovascular risk markers and events. Its discovery was directly related to the hydrolysis of the platelet-activating factor and oxidized phospholipids, which are considered protective functions. However, the hydrolysis of bioactive lipids generates lysophospholipids, compounds that have a pro-inflammatory function. Therefore, the evaluation of the distribution of Lp-PLA2 in the lipid fractions emphasized the dual role of the enzyme in the inflammatory process, since the HDL-Lp-PLA2 enzyme contributes to the reduction of atherosclerosis, while LDL-Lp-PLA2 stimulates this process. Recently, it has been verified that diet components and drugs can i... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5270825 Wed, 28 Sep 2011 04:00:00 +0100 5270825 http://www.medworm.com/index.php?rid=5258141&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F169 Background: Perilipin1, a lipid droplet associated protein has an important role in the regulation of lipolysis and lipid storage in adipocytes. Perilipin1 is also expressed in foam cells of atheroma plaques and could therefore play a role in the accumulation of lipids in arterial wall and in the development of atherosclerosis. The aim of the study was to investigate this possible role of perilipin1 in atherogenesis. Methods: Mice deficient in perilipin1 (Plin1-/-) were crossed with Ldlr-/- mice. Ldlr-/- and Plin1-/- Ldlr-/- mice received an atherogenic diet during 10 or 20 weeks. Blood pressure and plasma lipids concentrations were measured. Aortas were collected at the end of the atherogenic diet periods for quantification of atheroma lesions (en face method), histological and immunohist... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5258141 Sat, 24 Sep 2011 04:00:00 +0100 5258141 http://www.medworm.com/index.php?rid=5247537&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F167 Background: : We sought to examine whether epsilon-4 carrier status modifies the relation between body mass index (BMI) and HDL. The National Heart, Lung, and Blood Institute Family Heart Study included 657 families with high family risk scores for coronary heart disease and 588 randomly selected families of probands in the Framingham, Atherosclerosis Risk in Communities, and Utah Family Health Tree studies. We selected 1402 subjects who had epsilon-4 carrier status available. We used generalized estimating equations to examine the interaction between BMI and epsilon-4 allele carrier status on HDL after adjusting for age, gender, smoking, alcohol intake, mono- and poly-unsaturated fat intake, exercise, comorbidities, LDL, and family cluster. Results: : The mean (standard deviation) age of ... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5247537 Fri, 23 Sep 2011 04:00:00 +0100 5247537 http://www.medworm.com/index.php?rid=5247536&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F168 Conclusion: These findings indicate that both H and CH diet regimens increased body adiposity independent treatment and the age at which treatment was started, whereas these diets caused hyperglycemia and affected brain metabolism when started at an early age. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5247536 Fri, 23 Sep 2011 04:00:00 +0100 5247536 http://www.medworm.com/index.php?rid=5247538&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F166 Conclusions The hepatocytes swelling might be exhibited as a result of disturbances of membranes function that lead to massive influx of water and Na+ due to GNPs effects accompanied by leakage of lysosomal hydrolytic enzymes that lead to cytoplasmic degeneration and macromolecular crowding. Hydropic degeneration is a result of ion and fluid homestasis that lead to an increase of intracellular water. The vacuolated swelling of the cytoplasm of the hepatocytes of the GNPs treated rats might indicate acute and subacute liver injury induced by the GNPs. Binucleation represents a consequence of cell injury and is a sort of chromosomes hyperplasia which is usually seen in regenerating cells. The induced histological alterations might be an indication of injured hepatocytes due to GNPs toxicity ... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5247538 Thu, 22 Sep 2011 04:00:00 +0100 5247538 http://www.medworm.com/index.php?rid=5247543&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F161 Conclusion: This investigation showed that the M. vulgare essential oil has a potent antimicrobial activity against some Gram (+)pathogenic bacteria and Botrytis cinerea fungi. The present studies confirm the use of this essential oil as anticancer agent. Further research is required to evaluate the practical values of therapeutic applications. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5247543 Wed, 21 Sep 2011 04:00:00 +0100 5247543 http://www.medworm.com/index.php?rid=5247542&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F162 Conclusion: In conclusion, we consider worthy the measurement of LDL particle size due to its relationship with lipid profile and cardiovascular risk. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5247542 Wed, 21 Sep 2011 04:00:00 +0100 5247542 http://www.medworm.com/index.php?rid=5247541&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F163 Conclusions: The induced histological alterations might be an indication of injured renal tubules due to GNPs toxicity that became unable to deal with the accumulated residues resulting from metabolic and structural disturbances caused by these NPs. The findings may suggest that GNPs interact with proteins and enzymes of the renal tissue interfering with the antioxidant defense mechanism and leading to reactive oxygen species (ROS) generation which in turn may induce stress in the renal cells to undergo atrophy and necrosis. The produced alterations were size-dependent with smaller ones induced more affects and related with time exposure of GNPs. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5247541 Wed, 21 Sep 2011 04:00:00 +0100 5247541 http://www.medworm.com/index.php?rid=5247540&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F164 Conclusion: An excess fructose intake induced some signs of metabolic syndrome. However, protein malnutrition appeared to protect against the short term effects of fructose. In other hand, most responses to acute physical exercise were not influenced by early malnutrition and/or by the fructose overload. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5247540 Wed, 21 Sep 2011 04:00:00 +0100 5247540 http://www.medworm.com/index.php?rid=5247539&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F165 Conclusion: Most of the beneficial effects of the isolated treatments disappeared when the drug (rosuvastatin) and the protein (glycinin) were taken simultaneously. The association was shown not to interact additively, as noted in the plasma levels of total cholesterol and non-HDL cholesterol, and in the significant increase of cholesterol in the liver. Studies are in progress to identify the effects of peptides derived from the 11S globulin and their role in cholesterol metabolism. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5247539 Wed, 21 Sep 2011 04:00:00 +0100 5247539 http://www.medworm.com/index.php?rid=5235230&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F160 Conclusions: The associations of both GALNT2 rs2144300 and rs4846914 SNPs and serum lipid levels are different in the Mulao and Han populations. These discrepancies might partly result from different GALNT2 gene-enviromental interactions. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5235230 Tue, 20 Sep 2011 04:00:00 +0100 5235230 http://www.medworm.com/index.php?rid=5220316&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F159 Previous studies showed that gamma-linolenic acid (GLA, 18: 3 omega-6), arachidonic acid (AA, 20:4 omega -6), eicosapentaenoic acid (EPA, 20: 5 omega -3) and docosahexaenoic acid (DHA, 22:6 omega -3) have selective tumoricidal action. In the present study, it was observed that dihomo-gamma-linolenic acid (DGLA) and AA, EPA and DHA have cytotoxic action on both vincristine-sensitive (KB-3-1) and resistant (KB-ChR-8-5) cancer cells in vitro that appeared to be a free-radical dependent process but not due to the formation of prostaglandins, leukotrienes and thromboxanes. Uptake of vincristine and fatty acids was higher while their efflux was lower in KB-3-1 cells compared with KB-ChR-8-5 cells, suggesting that drug resistant cells have an effective efflux pump. GLA, DGLA, AA, EPA and DHA enha... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5220316 Wed, 14 Sep 2011 04:00:00 +0100 5220316 http://www.medworm.com/index.php?rid=5220317&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F158 Conclusions: MK-4 stimulates testosterone production in rats and testis-derived tumor cells via activation of PKA. MK-4 may be involved in steroidogenesis in the testis, and its supplementation could reverse the downregulation of testosterone production in elders. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5220317 Tue, 13 Sep 2011 04:00:00 +0100 5220317 http://www.medworm.com/index.php?rid=5220318&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F157 Conclusions: These results suggest hypertriglyceridemia is unlikely to be the primary cause of acute pancreatitis unless TG levels are > 20 mM, that dysglycemia, a diet high in carbohydrates and fats, and obesity are the main secondary causes of HTG, and that fibrates are frequently overlooked as the drug of first choice for severe HTG. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5220318 Sun, 11 Sep 2011 04:00:00 +0100 5220318 http://www.medworm.com/index.php?rid=5205394&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F156 Conclusions: These findings indicate that the TaqIB polymorphism may have potential importance in screening individuals at high risk for developing CAD. However, this polymorphism cannot distinguish between LMCAD and MPCAD. Further prospective investigations in larger populations are required to confirm these findings.. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5205394 Wed, 07 Sep 2011 04:00:00 +0100 5205394 http://www.medworm.com/index.php?rid=5205395&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F155 Background: Recent studies have highlighted the potential of cell therapy for atherosclerosis. The aim of this study was to evaluate the effects of mononuclear cell (MNC) therapy on the development of atherosclerotic lesions in the apolipoprotein E knockout (apoE KO) mouse. Methods: We investigated vascular lipid deposition, vascular remodeling, oxidative stress, and endothelial nitric oxide synthase (eNOS) expression in apoE KO mice treated with spleen MNCs isolated from lacZ transgenic mice (apoE KO-MNC) for 8 weeks compared to untreated control mice (apoE KO). Results: Histological analysis of aortas showed a significant reduction in the lipid deposition area in apoE KO-MNC mice compared to apoE KO mice (0.051 +/- 0.004 vs 0.117 +/- 0.016 mm2, respectively, p (Source: Lipids in Health a... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5205395 Tue, 06 Sep 2011 04:00:00 +0100 5205395 http://www.medworm.com/index.php?rid=5174424&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F154 Conclusion: Raised ApoM levels in HBV infection may in turn suppress HBV replication, one of the protective mechanisms of nature. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5174424 Sun, 28 Aug 2011 23:00:00 +0100 5174424 http://www.medworm.com/index.php?rid=5174425&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F153 Conclusions: The chronic stress and high-fat-diet have the synergistic action in rat's Lipid Metabolism Disorder. They lead to a model of Lipid Metabolism Disorder, which conforms to human clinical characteristic much better. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5174425 Sat, 27 Aug 2011 23:00:00 +0100 5174425 http://www.medworm.com/index.php?rid=5157977&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F152 This is a case report of adrenomyeloneuropathy (AMN), the adult variant of adrenoleukodystryphy (ALD). The diagnoses in the patient, aged 34, was confirmed via increased serum very long chain fatty acid concentration (VLCFA). Treatment started with the cholesterol lowering drug, atorvastatin, followed by add-on therapy with Lorenzo's oil (LO) and finally supplementation with docosahexaenoic acid (DHA). The magnetic resonance imaging (MRI) scan of the AMN patient before DHA treatment, already showed abnormal white matter in the brain. Although the MRI showed no neurological improvement after 6 months of DHA treatment, no selective progression of demyelination was detected in the AMN patient. Contrary to what was expected, LO failed to sustain or normalize the VLCFA levels or improve clinica... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5157977 Thu, 25 Aug 2011 23:00:00 +0100 5157977 http://www.medworm.com/index.php?rid=5157979&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F150 Conclusions: Phytoceramide and yeast-derived sphingoid bases activate PPARs, whereas ceramide and dihydroceramide do not change the PPAR activity. The present findings suggest that phytoceramide acts as a PPAR ligand that would regulate PPAR-targeted genes. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5157979 Tue, 23 Aug 2011 23:00:00 +0100 5157979 http://www.medworm.com/index.php?rid=5157978&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F151 Conclusion: We found an inverse association between PUFA intake and depression symptoms in Iranian postgraduate students in Malaysia. We, therefore, concluded that long-term intake of PUFAs may modify or prevent depression symptoms. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5157978 Tue, 23 Aug 2011 23:00:00 +0100 5157978 http://www.medworm.com/index.php?rid=5157981&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F148 Sleep is an integral part of good health. Sleep disorders and variations in sleep habits are associated with a low-grade inflammatory status, which may be either a cause or consequence of other conditions, including obesity, diabetes and cardiovascular disease. Several strategies are available to counteract these conditions including continuous positive airway pressure (CPAP), pharmacological and nutritional interventions, and even surgery. At present, our group is investigating the effect of chronic endurance exercise on sleep alterations. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5157981 Mon, 22 Aug 2011 23:00:00 +0100 5157981 http://www.medworm.com/index.php?rid=5157980&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F149 Conclusion: In conclusion, antioxidant quercetin could protect against Dimethoate-induced oxidative stress by decreasing lipid peroxidation, protein oxidation and increasing superoxide dismutase and catalase activities in human lymphocytes. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5157980 Mon, 22 Aug 2011 23:00:00 +0100 5157980 http://www.medworm.com/index.php?rid=5157984&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F145 Conclusion: Further studies with a larger sample size carried out over a longer period are needed to substantiate our findings and to determine differences in EPA+DHA bioavailability between three common chemical forms of LC n-3 FA (rTAG, EE and krill oil). The unexpected high content of free EPA and DHA in krill oil, which might have a significant influence on the availability of EPA+DHA from krill oil, should be investigated in more depth and taken into consideration in future trials. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5157984 Sun, 21 Aug 2011 23:00:00 +0100 5157984 http://www.medworm.com/index.php?rid=5157983&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F146 Background: Despite documented benefits of lipid-lowering treatment in women, a considerable number are undertreated, and fewer achieve treatment targets vs. men. Methods: Data were combined from 27 double-blind, active or placebo-controlled studies that randomized adult hypercholesterolemic patients to statin or statin+ezetimibe. Consistency of treatment effect among men (n=11,295) and women (n=10,499) was assessed and percent of men and women was calculated to evaluate the between-treatment ability to achieve specified treatment levels between sexes. Results: Baseline lipids and hs-CRP were generally higher in women vs. men. Between-treatment differences were significant for both sexes (all p (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5157983 Sun, 21 Aug 2011 23:00:00 +0100 5157983 http://www.medworm.com/index.php?rid=5157982&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F147 Conclusions: The induced histological alterations might be an indication of injured renal tubules due to GNPs toxicity that become unable to deal with the accumulated residues resulting from metabolic and structural disturbances caused by these NPs. These alterations were size-dependent with smaller ones induced more effects and related with time exposure of GNPs. The produced histological alterations may suggest that GNPs interact with proteins and enzymes of the renal tissue interfering with the antioxidant defense mechanism and leading to reactive oxygen species (ROS) generation which in turn may induce stress in the renal cells to undergo atrophy and necrosis. More histomorphologcal investigations are needed to address the potential therapeutic and diagnostic tool of GNPs. (Source: Lip... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5157982 Sun, 21 Aug 2011 23:00:00 +0100 5157982 http://www.medworm.com/index.php?rid=5157985&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F140 Conclusions: Several common SNPs and their haplotypes in the ApoA1/C3/A5 gene cluster are closely associated with modifications of serum lipid parameters in the general Chinese population. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5157985 Thu, 18 Aug 2011 23:00:00 +0100 5157985 http://www.medworm.com/index.php?rid=5125525&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F138 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5125525 Fri, 12 Aug 2011 23:00:00 +0100 5125525 http://www.medworm.com/index.php?rid=5125527&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F136 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5125527 Thu, 11 Aug 2011 23:00:00 +0100 5125527 http://www.medworm.com/index.php?rid=5125526&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F137 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5125526 Thu, 11 Aug 2011 23:00:00 +0100 5125526 http://www.medworm.com/index.php?rid=5107095&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F135 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5107095 Sun, 07 Aug 2011 23:00:00 +0100 5107095 http://www.medworm.com/index.php?rid=5103191&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F133 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5103191 Thu, 04 Aug 2011 23:00:00 +0100 5103191 http://www.medworm.com/index.php?rid=5103190&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F134 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5103190 Thu, 04 Aug 2011 23:00:00 +0100 5103190 http://www.medworm.com/index.php?rid=5095251&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F129 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5095251 Wed, 03 Aug 2011 23:00:00 +0100 5095251 http://www.medworm.com/index.php?rid=5095250&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F130 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5095250 Wed, 03 Aug 2011 23:00:00 +0100 5095250 http://www.medworm.com/index.php?rid=5095249&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F131 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5095249 Wed, 03 Aug 2011 23:00:00 +0100 5095249 http://www.medworm.com/index.php?rid=5095248&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F132 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5095248 Wed, 03 Aug 2011 23:00:00 +0100 5095248 http://www.medworm.com/index.php?rid=5095252&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F128 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5095252 Mon, 01 Aug 2011 23:00:00 +0100 5095252 http://www.medworm.com/index.php?rid=5085736&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F127 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5085736 Fri, 29 Jul 2011 23:00:00 +0100 5085736 http://www.medworm.com/index.php?rid=5077324&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F126 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5077324 Thu, 28 Jul 2011 23:00:00 +0100 5077324 http://www.medworm.com/index.php?rid=5069094&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F123 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5069094 Mon, 25 Jul 2011 23:00:00 +0100 5069094 http://www.medworm.com/index.php?rid=5069093&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F124 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5069093 Mon, 25 Jul 2011 23:00:00 +0100 5069093 http://www.medworm.com/index.php?rid=5069092&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F125 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5069092 Mon, 25 Jul 2011 23:00:00 +0100 5069092 http://www.medworm.com/index.php?rid=5061871&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F122 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5061871 Sun, 24 Jul 2011 23:00:00 +0100 5061871 http://www.medworm.com/index.php?rid=5049594&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F121 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5049594 Wed, 20 Jul 2011 23:00:00 +0100 5049594 http://www.medworm.com/index.php?rid=5049593&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F120 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5049593 Wed, 20 Jul 2011 23:00:00 +0100 5049593 http://www.medworm.com/index.php?rid=5049596&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F118 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5049596 Sun, 17 Jul 2011 23:00:00 +0100 5049596 http://www.medworm.com/index.php?rid=5049595&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F119 ${item.shortDescription} (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5049595 Sun, 17 Jul 2011 23:00:00 +0100 5049595 http://www.medworm.com/index.php?rid=5018841&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F116 Conclusion: These data suggest that Bifidobacterium spp. used in this study may have beneficial antiobesity effects. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5018841 Mon, 11 Jul 2011 23:00:00 +0100 5018841 http://www.medworm.com/index.php?rid=5018842&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F115 Conclusions: In summary, lipotoxicity is evident not only in the presence of high but also low glucose concentrations. Additional effects of glucose are prominent in INS-1E but not in MIN6 cells and intact control human islets, which are able to efficiently oxidize fatty acids at high glucose and in this way avoid glucolipotoxicity. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5018842 Sun, 10 Jul 2011 23:00:00 +0100 5018842 http://www.medworm.com/index.php?rid=5007591&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F114 Conclusion: This study demonstrates that GAK administration specifically (1.5mg/kg/BW/rat) can effectively improve liver fibrosis caused by DMN, and may be used as a therapeutic option and preventive measure against hepatic fibrosis. Further human trial would be applied specially GAK is a part of Egyptian diet. The act of why high amounts of GAK was improved biochemical values compare to low or moderate levels tested in this study may be due to increase levels of oleic acid and other polyphenols in apricot kernels (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5007591 Wed, 06 Jul 2011 23:00:00 +0100 5007591 http://www.medworm.com/index.php?rid=5007592&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F113 Aging and physical inactivity are two factors that favors the development of cardiovascular disease, metabolic syndrome, obesity, diabetes, and sleep dysfunction. In contrast, the adoption a habitual of moderate exercise may present a non-pharmacological treatment alternative for sleep and metabolic disorders. We aimed to assess the effects of moderate exercise training on sleep quality and on the metabolic profile of elderly people with a sedentary lifestyle. Fourteen male sedentary, healthy, elderly volunteers performed moderate training for 60 minutes by day, 3 days by week for 24 wk at a work rate equivalent to the ventilatory aerobic threshold. The environment was kept at a temperature of 23 +/- 2C, with an air humidity 60 +/- 5%. Blood and polysomnographs analysis were collected 3 ti... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5007592 Tue, 05 Jul 2011 23:00:00 +0100 5007592 http://www.medworm.com/index.php?rid=5007593&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F112 ObjectiveTo investigate effects of lipid lowering drug, simvastatin, on apolipoprotein M expression in the hyperlipidemic mice and in hepatic cell line, HepG2 cells. Methods: Swiss male mice were randomly divided into the high fat group and control group, and were intragastrically fed with 0.9% salinecontrol groupor lipid emulsion (high fat group) at the daily dosage of 15 ml/kg body weight, respectively. After 8 weeks feeding, the hyperlipidemic model was successfully induced and these hyperlipidemic mice were then randomly divided into three experimental groups: vehicle control group, high-dose simvastatin-treated group (100 mg/kg body weight), and low-dose simvastatin-treated group (10 mg/kg body weight). Mice were dosed daily for 6 weeks of simvastatin before mice were sacrificed for d... Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=5007593 Mon, 04 Jul 2011 23:00:00 +0100 5007593 http://www.medworm.com/index.php?rid=4992204&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F111 Conclusion: The results of this study demonstrate the presence of increased combined oxidative modifications in lipids, proteins in B95-8 and Raji cells lines after EBV lytic cycle induction. These results suggest that lipid peroxidation, protein oxidation and DNA fragmentation are generally induced during EBV lytic cycle induction and probably contribute to the cytopathic effect of EBV. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=4992204 Thu, 30 Jun 2011 23:00:00 +0100 4992204 http://www.medworm.com/index.php?rid=4984106&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F109 Conclusions: Gender and BMI are important influencing factors for TG metabolism after fat meal in the youth. The young male persons with over-BMI have abnormal TG. metabolism. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=4984106 Wed, 29 Jun 2011 23:00:00 +0100 4984106 http://www.medworm.com/index.php?rid=4984105&cid=s_29184_162_f&fid=29184&url=http%3A%2F%2Fwww.lipidworld.com%2Fcontent%2F10%2F1%2F110 Conclusions: Chronic systemic inflammation increased lipogenesis in nonadipose tissues and lipolysis in white adipose tissue, resulting in ectopic lipid deposition in nonadipose tissues. This disturbed free fatty acid homeostasis and caused insulin resistance in C57BL/6J mice. (Source: Lipids in Health and Disease) Lipids in Health and Disease journals http://www.medworm.com/rss/comments.php?id=4984105 Wed, 29 Jun 2011 23:00:00 +0100 4984105