MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Liver International' source. Wed, 08 Feb 2012 16:28:26 +0100 http://www.medworm.com/index.php?rid=5667844&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2012.02763.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5667844 Wed, 08 Feb 2012 05:00:00 +0100 5667844 http://www.medworm.com/index.php?rid=5667846&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02754.x ConclusionsOur results indicate that DCs in CHC patients exhibiting mature and functional phenotype prior to therapy achieve sustained virological response suggesting that functional modulation of defective DCs is directly associated with successful response to therapy. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5667846 Mon, 06 Feb 2012 05:00:00 +0100 5667846 http://www.medworm.com/index.php?rid=5667845&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2012.02759.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5667845 Mon, 06 Feb 2012 05:00:00 +0100 5667845 http://www.medworm.com/index.php?rid=5667843&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2012.02755.x AbstractIschaemia reperfusion (IR) injury is a clinical entity with a major contribution to the morbidity and mortality of liver surgery and transplantation. A central pathway of protection against IR injury utilizes nitric oxide (NO). Nitric oxide synthase (NOS) enzymes manufacture NO from L‐arginine. NO generated by the endothelial NOS (eNOS) isoform protects against liver IR injury, whereas inducible NOS (iNOS)‐derived NO may have either a protective or a deleterious effect during the early phase of IR injury, depending on the length of ischaemia, length of reperfusion and experimental model. In late phase hepatic IR injury, iNOS‐derived NO plays a protective role. In addition to NOS consumption of L‐arginine during NO synthesis, this amino acid may also be metabolized by argina... Liver International journals http://www.medworm.com/rss/comments.php?id=5667843 Wed, 01 Feb 2012 05:00:00 +0100 5667843 http://www.medworm.com/index.php?rid=5649005&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02753.x AbstractThe accuracy of the Framingham risk score (FRS) in identifying patients with nonalcoholic fatty liver disease (NAFLD) at higher 10‐year coronary heart disease (CHD) risk remains unknown. We aimed at evaluating both the baseline probability of CHD as predicted by the FRS and the actual long‐term occurrence of CHD in NAFLD patients. This was a longitudinal study of a community‐based cohort. A total of 309 NAFLD patients were followed up for 11.5 ± 4.1 years (total 3554 person‐years). The overall calculated 10‐year CHD risk was significantly higher in the NAFLD cohort than the absolute CHD risk predicted by the FRS for persons of the same age and gender (10.9 ± 9.3% vs. 9.9 ± 5.9%, respectively, P < 0.0001), and higher in men than women (12.6 ± 10.3% vs. 9.... Liver International journals http://www.medworm.com/rss/comments.php?id=5649005 Wed, 01 Feb 2012 05:00:00 +0100 5649005 http://www.medworm.com/index.php?rid=5649011&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02743.x ConclusionWe report a novel protocol for hESC differentiation into morphological and functional yet immature hepatocytes as an alternative method for hepatocyte generation. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5649011 Tue, 31 Jan 2012 05:00:00 +0100 5649011 http://www.medworm.com/index.php?rid=5649010&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2012.02756.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5649010 Tue, 31 Jan 2012 05:00:00 +0100 5649010 http://www.medworm.com/index.php?rid=5649009&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2012.02757.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5649009 Tue, 31 Jan 2012 05:00:00 +0100 5649009 http://www.medworm.com/index.php?rid=5649008&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02751.x AbstractCirrhotic cardiomyopathy (CCM), a condition of unknown pathogenesis, is characterized by suboptimal ventricular contractile response to stress, diastolic dysfunction and QT interval prolongation. It is most often found in patients with advanced cirrhosis. It is clinically relevant during stressful conditions, such as sepsis, bleeding and surgery. CCM reverses after liver transplantation and potentially has a role in the pathogenesis of hepatorenal syndrome. In adrenal insufficiency (AI), cardiac dysfunction is a feature with low ejection fraction, decreased left ventricular chamber size and electrocardiographic abnormalities, including QT interval prolongation. With optimal diagnostic tests, AI is present in approximately 10% of patients with cirrhosis, particularly in those with a... Liver International journals http://www.medworm.com/rss/comments.php?id=5649008 Tue, 31 Jan 2012 05:00:00 +0100 5649008 http://www.medworm.com/index.php?rid=5649007&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2012.02752.x ConclusionsLong‐term ethanol feeding promoted steatosis and fibrosis in LE rats via EGR1 activation. The highly abundant EGR1 bound to the SREBP1c promoter and contributed to the steatosis observed in the LE rat model. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5649007 Tue, 31 Jan 2012 05:00:00 +0100 5649007 http://www.medworm.com/index.php?rid=5649006&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2012.02762.x ConclusionThese results indicate that the nervous system has a central role in the genesis of the circulatory abnormalities of portal hypertension, and support that mesenteric sympathetic atrophy contributes to splanchnic arterial vasodilation. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5649006 Tue, 31 Jan 2012 05:00:00 +0100 5649006 http://www.medworm.com/index.php?rid=5629596&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2012.02760.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5629596 Thu, 26 Jan 2012 21:16:10 +0100 5629596 http://www.medworm.com/index.php?rid=5629598&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02747.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5629598 Thu, 26 Jan 2012 05:00:00 +0100 5629598 http://www.medworm.com/index.php?rid=5629597&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02750.x ConclusionsMiR‐122 expression is down‐regulated in human HCC. Over‐expression of miR‐122 inhibits HCC cell growth and promotes the cell apoptosis by affecting Wnt/β‐catenin‐TCF signalling pathway. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5629597 Thu, 26 Jan 2012 05:00:00 +0100 5629597 http://www.medworm.com/index.php?rid=5629599&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02738.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5629599 Wed, 25 Jan 2012 05:00:00 +0100 5629599 http://www.medworm.com/index.php?rid=5609854&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02749.x ConclusionsIt is recommendable to lower the current ALT thresholds to better identify individuals at risk for chronic liver disease. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5609854 Fri, 20 Jan 2012 20:52:27 +0100 5609854 http://www.medworm.com/index.php?rid=5598617&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2012.02758.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5598617 Tue, 17 Jan 2012 21:49:47 +0100 5598617 http://www.medworm.com/index.php?rid=5583134&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02644.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5583134 Sat, 14 Jan 2012 06:17:38 +0100 5583134 http://www.medworm.com/index.php?rid=5583133&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02645.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5583133 Sat, 14 Jan 2012 06:17:03 +0100 5583133 http://www.medworm.com/index.php?rid=5583132&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02671.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5583132 Sat, 14 Jan 2012 06:16:55 +0100 5583132 http://www.medworm.com/index.php?rid=5583129&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02745.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5583129 Sat, 14 Jan 2012 06:15:04 +0100 5583129 http://www.medworm.com/index.php?rid=5583131&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02739.x ConclusionThe use of nsNSAIDs but not celecoxib was associated with a two‐fold increased risk of variceal and non‐variceal upper GI events among cirrhotic patients. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5583131 Mon, 09 Jan 2012 05:00:00 +0100 5583131 http://www.medworm.com/index.php?rid=5583130&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02742.x ConclusionSerum IL‐27 can trigger immune response to prevent hepatic injury in different clinical‐pathologic stages of HBV‐infected patients earlier, but IL‐6 may play an extremely important role to determine the liver progression. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5583130 Mon, 09 Jan 2012 05:00:00 +0100 5583130 http://www.medworm.com/index.php?rid=5560983&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02741.x ConclusionCombination of the MEF co‐culture system with the addition of inhibitors of TGFβ and GSK3β induced in vitro expansion of hepatocytes. Moreover, expression of mature hepatocellular genes and the activity of drug‐metabolism enzymes in expanded hepatocytes were re‐induced after spheroid culture. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5560983 Wed, 04 Jan 2012 05:00:00 +0100 5560983 http://www.medworm.com/index.php?rid=5560982&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02731.x AbstractIn November 2010, the Spanish Society of Liver Transplantation (Sociedad Española de Trasplante Hepático, SETH) held a consensus conference. One of the topics of debate was liver transplantation in patients with hepatitis C. This document reviews (i) the natural history of post‐transplant hepatitis C, (ii) factors associated with post‐transplant prognosis in patients with hepatitis C, (iii) the role of immunosuppression in the evolution of recurrent hepatitis C and response to antiviral therapy, (iv) antiviral therapy, both before and after transplantation, (v) follow‐up of patients with recurrent hepatitis C and (vi) the role of retransplantation. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5560982 Wed, 04 Jan 2012 05:00:00 +0100 5560982 http://www.medworm.com/index.php?rid=5560985&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02722.x ConclusionsIn HCV‐infected individuals, OOP and time costs represent a significant economic burden and fall disproportionately upon those least able to afford them. The lower cost burden among those who were successfully treated suggests that wider use of antiviral therapy may reduce economic burden in addition to improving health outcomes. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5560985 Tue, 03 Jan 2012 05:00:00 +0100 5560985 http://www.medworm.com/index.php?rid=5560984&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02732.x ConclusionsThe primary effect of diffuse, whole‐liver expression of either mutant ras gene in fetal or adult mouse liver is diffuse and progressive hepatic growth. HrasG12V mutation influences hepatocarcinogenesis by conferring cell autonomous growth potential upon foci of expressing cells and by increasing the risk of neoplastic progression. KrasG12D does not share these latter carcinogenic effects in mouse liver. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5560984 Tue, 03 Jan 2012 05:00:00 +0100 5560984 http://www.medworm.com/index.php?rid=5560981&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02735.x ConclusionsOur findings show a significant association of 25(OH)D with the degree of liver dysfunction and suggest that low 25(OH)D levels may predict hepatic decompensation and mortality in patients with chronic liver failure. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5560981 Sun, 01 Jan 2012 05:00:00 +0100 5560981 http://www.medworm.com/index.php?rid=5598621&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02724.x ConclusionJamun fruit phytochemicals decreased hepatic inflammation and oxidative stress, and protected against hepatocellular injury in mice. Jamun warrants further investigation as a potential antioxidant/anti‐inflammatory therapy not only to treat cholestasis but also other liver diseases with an inflammatory component. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5598621 Fri, 30 Dec 2011 05:00:00 +0100 5598621 http://www.medworm.com/index.php?rid=5560993&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02724.x ConclusionJamun fruit phytochemicals decreased hepatic inflammation and oxidative stress, and protected against hepatocellular injury in mice. Jamun warrants further investigation as a potential antioxidant/anti‐inflammatory therapy not only to treat cholestasis but also other liver diseases with an inflammatory component. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5560993 Fri, 30 Dec 2011 05:00:00 +0100 5560993 http://www.medworm.com/index.php?rid=5560992&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02727.x ConclusionsThe SNP at the major ribavirin transporter ENT1 gene SLC29A1 was one of significantly independent factors influencing treatment response, although the impact on the prediction was small. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5560992 Fri, 30 Dec 2011 05:00:00 +0100 5560992 http://www.medworm.com/index.php?rid=5560991&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02737.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5560991 Fri, 30 Dec 2011 05:00:00 +0100 5560991 http://www.medworm.com/index.php?rid=5560990&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02730.x AbstractNon‐alcoholic fatty liver disease (NAFLD) and the more severe non‐alcoholic steatohepatitis (NASH) represent a spectrum of diseases involving hepatic fat accumulation and histological features essentially identical to alcoholic liver disease; however, they occur in the absence of excessive alcohol intake. They typically arise in conjunction with one or more features of the metabolic syndrome. Lifestyle mediated weight loss remains the primary mode of therapy for NAFLD and NASH, but this is often ineffective and adjunctive medical and surgical treatments are presently lacking. Prebiotic fibres are a group of non‐digestible carbohydrates that modulate the human microbiota in a manner that is advantageous to host health. Rodent studies suggest that dietary supplementation with p... Liver International journals http://www.medworm.com/rss/comments.php?id=5560990 Fri, 30 Dec 2011 05:00:00 +0100 5560990 http://www.medworm.com/index.php?rid=5560989&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02734.x ConclusionsAlthough the outcome of AIH is as good if not better among Japanese than for other populations, there was an increased risk of HCC in these patients. Cirrhosis at presentation was predictive of development of HCC in AIH in Japan. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5560989 Fri, 30 Dec 2011 05:00:00 +0100 5560989 http://www.medworm.com/index.php?rid=5560988&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02736.x ConclusionsThe diagnostic accuracy of ARFI liver and spleen was comparable to TE and Fibrotest for the detection of complications in patients with cirrhosis. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5560988 Fri, 30 Dec 2011 05:00:00 +0100 5560988 http://www.medworm.com/index.php?rid=5560987&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02733.x ConclusionThis novel sensitive method can be used for not only assessing IFN‐β activation or inhibition in the liver under different conditions, but also screening drug candidates of stimulating or inhibiting of IFN‐β production. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5560987 Fri, 30 Dec 2011 05:00:00 +0100 5560987 http://www.medworm.com/index.php?rid=5538539&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02696.x ConclusionOur study demonstrated that from normal liver to the adjacent cirrhotic liver and to the HCC tissues, p16INK4a hypermethylation was gradually increased both in frequency and in intensity, such increase might be gender and age related. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5538539 Sun, 25 Dec 2011 09:17:02 +0100 5538539 http://www.medworm.com/index.php?rid=5515903&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02729.x ConclusionTreatment with sorafenib led to a potent inhibition of cell viability, tumour progression and angiogenesis. Sorafenib might therefore also be a promising treatment option for high risk or recurrent HB. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5515903 Mon, 19 Dec 2011 09:07:46 +0100 5515903 http://www.medworm.com/index.php?rid=5515904&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02728.x ConclusionsPopulation dynamics of the three lineages shared some common characteristics, but had distinguishing features. The appearance of 3a and 3e lineages coincides with the increase of large‐race pig importation from Europe and the USA after 1960. The epidemic phase of 3a and 3b strains from 1960 to 1980 could be related to increased opportunity for HEV infection arising from large‐scale pig breeding since 1960. Our observations revealed new findings concerning the close relationship between the epidemic history of Japan‐indigenous genotype 3 HEV and the improvement of the Japanese pig industry. Infection control in pig farms should be an effective method of preventing HEV infection in humans. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5515904 Sun, 18 Dec 2011 05:00:00 +0100 5515904 http://www.medworm.com/index.php?rid=5505881&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02721.x ConclusionsThese findings support the hypothesis that progenitor cells exist in the EHBD and that the peribiliary glands can be considered a local progenitor cell niche in the human EHBD. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5505881 Fri, 16 Dec 2011 09:20:26 +0100 5505881 http://www.medworm.com/index.php?rid=5487737&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02658.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5487737 Sat, 10 Dec 2011 09:55:44 +0100 5487737 http://www.medworm.com/index.php?rid=5487736&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02723.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5487736 Sat, 10 Dec 2011 09:55:40 +0100 5487736 http://www.medworm.com/index.php?rid=5487733&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02697.x ConclusionThese results reveal that the TNF‐α genetic polymorphism ‐308G/A is significantly associated with ATD‐induced hepatitis. This genetic variant may be a risk factor for ATD‐induced hepatitis in individuals from Korea. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5487733 Sat, 10 Dec 2011 09:53:56 +0100 5487733 http://www.medworm.com/index.php?rid=5487735&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02698.x ConclusionReduction in ammonia with OP in cirrhotic rats prevents LPS‐induced brain edema and delays coma, suggesting that ammonia may prime the brain to the deleterious effect of LPS, possibly through effects on iNOS and NFκB related mechanisms. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5487735 Thu, 08 Dec 2011 05:00:00 +0100 5487735 http://www.medworm.com/index.php?rid=5487734&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02674.x ConclusionLow 25‐OH vitamin D plasma levels and the unfavourable VDR bAt[CCA]‐haplotype are associated with rapid fibrosis progression in chronic HCV patients. In combination, both variables exert significant additive effects on fibrosis progression. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5487734 Thu, 08 Dec 2011 05:00:00 +0100 5487734 http://www.medworm.com/index.php?rid=5477231&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02684.x ConclusionThis updated analysis based on the complete region of HCV confirmed the validity of the previously assigned genotypes/subtypes and provided an up‐to‐date reference for future basic research and clinical studies. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5477231 Mon, 05 Dec 2011 05:00:00 +0100 5477231 http://www.medworm.com/index.php?rid=5477235&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02694.x ConclusionCTLA‐4 gene polymorphisms were associated to HCV‐infection. Eight AT repetitions were more prevalent in HCV‐infected subjects. −318C and + 49G alleles were associated to genotypes 1 and 3 infections and increased number of AT repetitions in 3′UTR region favoured severe necroinflammatory activity scores in liver biopsies. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5477235 Sun, 04 Dec 2011 05:00:00 +0100 5477235 http://www.medworm.com/index.php?rid=5477234&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02678.x ConclusionOptimal ALP and Bilirubin levels can be used as appropriate biochemical criteria for patient selection and defining treatment success in future clinical trials in patients with PBC. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5477234 Sun, 04 Dec 2011 05:00:00 +0100 5477234 http://www.medworm.com/index.php?rid=5477233&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02685.x ConclusionMurine NAFLD is associated with portal hypercortisolism and11β‐HSD1 overexpression in VAT. In humans, 11β‐HSD1 VAT expression was associated with the presence of NAFLD. Thus, local corticosteroid production in VAT may contribute to NAFLD pathogenesis. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5477233 Sun, 04 Dec 2011 05:00:00 +0100 5477233 http://www.medworm.com/index.php?rid=5477232&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02692.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5477232 Sun, 04 Dec 2011 05:00:00 +0100 5477232 http://www.medworm.com/index.php?rid=5469579&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02695.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5469579 Fri, 02 Dec 2011 05:00:00 +0100 5469579 http://www.medworm.com/index.php?rid=5469578&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02687.x ConclusionsTargeting PDGFR‐β sensitizes CCA cells to apoptotic stimuli and appears to be therapeutic in vivo. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5469578 Fri, 02 Dec 2011 05:00:00 +0100 5469578 http://www.medworm.com/index.php?rid=5469577&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02681.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5469577 Fri, 02 Dec 2011 05:00:00 +0100 5469577 http://www.medworm.com/index.php?rid=5469576&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02688.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5469576 Fri, 02 Dec 2011 05:00:00 +0100 5469576 http://www.medworm.com/index.php?rid=5458686&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02693.x ConclusionsAlthough it is inferior to other genotypes and to serum HBV DNA alone, single‐point HBsAg level has a favourable diagnostic accuracy in genotype C HBeAg‐negative HBV carriers and is expected to provide additional information for managing chronic hepatitis B. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5458686 Wed, 30 Nov 2011 05:00:00 +0100 5458686 http://www.medworm.com/index.php?rid=5432313&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02686.x ConclusionsA reduced frequency of the protective YKL‐40 promoter polymorphism was not observed in the HALT‐C Trial patient population. The absence of an association between YKL‐40 promoter polymorphisms and baseline liver disease severity as well as with the risk of liver disease progression over time suggests that this polymorphism is not associated with disease progression in CHC patients with established fibrosis. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5432313 Tue, 22 Nov 2011 05:00:00 +0100 5432313 http://www.medworm.com/index.php?rid=5432312&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02677.x ConclusionIn conclusion, smoking at time of LT was predictive of flare of IBD and active IBD at time of transplantation had a significant effect on graft survival. Medical therapy needs to be maximised in the pre‐LT period. Patients with poorly controlled IBD refractory to medical therapy should be considered for colectomy at time of transplantation. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5432312 Tue, 22 Nov 2011 05:00:00 +0100 5432312 http://www.medworm.com/index.php?rid=5409351&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02682.x AbstractDespite a decline in cases of acute hepatitis B and the low hepatitis B virus (HBV) chronicity rates in adults, still some patients progress to HBV‐related fulminant liver failure. In this review, we discuss treatment options that may prevent the progression of severe acute hepatitis B to fulminant liver failure and death. In severe acute HBV with prolonged prothrombin time and increased bilirubin, interferon failed to be effective while antiviral treatment, particularly with lamivudine, appears to improve survival (mean survival almost 80%). Outcome without antiviral therapy has remained considerably poor, whereas there is no convincing evidence of amelioration of HBV‐targeted immunity. Of note, most patients who died or required transplantation despite lamivudine therapy, wer... Liver International journals http://www.medworm.com/rss/comments.php?id=5409351 Tue, 15 Nov 2011 05:00:00 +0100 5409351 http://www.medworm.com/index.php?rid=5409350&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02680.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5409350 Tue, 15 Nov 2011 05:00:00 +0100 5409350 http://www.medworm.com/index.php?rid=5409349&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02672.x Discussion and conclusionIn this mostly asymptomatic PSC‐patient population, 33% demonstrated abnormal brush cytology or aneuploidity. Determining DNA ploidy and brush cytology during ERCP offers a useful tool for identifying those PSC patients who are at high risk of developing cholangiocancer. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5409349 Tue, 15 Nov 2011 05:00:00 +0100 5409349 http://www.medworm.com/index.php?rid=5409352&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02683.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5409352 Mon, 14 Nov 2011 05:00:00 +0100 5409352 http://www.medworm.com/index.php?rid=5388373&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02673.x Conclusionsb‐GGT increases in NAFLD, but not in CHC. GGT fraction analysis might help in improving the sensitivity and specificity of the diagnosis of NAFLD and other liver dysfunctions. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5388373 Thu, 03 Nov 2011 04:00:00 +0100 5388373 http://www.medworm.com/index.php?rid=5477230&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02689.x ConclusionsC‐reactive protein on its own is a sensitive screening test for the presence of bacterial infections in cirrhosis and is also a useful marker to predict the likelihood of clinically significant bacterial infections in patients without overt infections. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5477230 Tue, 01 Nov 2011 04:00:00 +0100 5477230 http://www.medworm.com/index.php?rid=5469575&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02690.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5469575 Tue, 01 Nov 2011 04:00:00 +0100 5469575 http://www.medworm.com/index.php?rid=5458685&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02691.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5458685 Tue, 01 Nov 2011 04:00:00 +0100 5458685 http://www.medworm.com/index.php?rid=5449997&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02675.x ConclusionsIncreased Foxp3+ Tregs may represent a prognostic predictor in patients with early stage HCC. The CHB natural history influenced density of tumour‐infiltrating Tregs in hepatocellular carcinoma patients with chronic hepatitis B viruses infection. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5449997 Tue, 01 Nov 2011 04:00:00 +0100 5449997 http://www.medworm.com/index.php?rid=5432311&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02660.x ConclusionsIn HBV patients, TE measurement accurately predicts the absence or presence of significant fibrosis, advanced fibrosis or cirrhosis and shows similar performances as compared to HCV patients. The use of TE cut‐off values adjusted to ALT level did not improve performances for estimating liver fibrosis in HBV patients. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5432311 Tue, 01 Nov 2011 04:00:00 +0100 5432311 http://www.medworm.com/index.php?rid=5422966&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02676.x ConclusionsAlthough HBV DNA suppression was more potent in the entecavir group than the lamivudine group, early mortality rates did not differ between the two groups. The baseline CTP score and MELD score 3 months after initiating antiviral treatment were significant predictors of early mortality. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5422966 Tue, 01 Nov 2011 04:00:00 +0100 5422966 http://www.medworm.com/index.php?rid=5409348&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02679.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5409348 Tue, 01 Nov 2011 04:00:00 +0100 5409348 http://www.medworm.com/index.php?rid=5388374&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02664.x ConclusionsThere are differential regulatory roles for hepatic RXRα, both in basal and inflammatory states, suggesting new and complex multidomain roles for RXRα in regulating hepatic gene expression. Moreover, there is an unexpected non‐obligate role for the DBD of RXRα. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5388374 Tue, 01 Nov 2011 04:00:00 +0100 5388374 http://www.medworm.com/index.php?rid=5388372&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02668.x ConclusionsSome patients treated for biliary atresia will survive into adulthood with their native liver, but commonly with secondary biliary disease including cholangitis and portal hypertension. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5388372 Tue, 01 Nov 2011 04:00:00 +0100 5388372 http://www.medworm.com/index.php?rid=5362349&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02666.x Discussion and conclusionThe results from this study provide strong evidence of a role for the SphK1/S1P/EDG1 pathway in liver metastasis, thus making it an attractive therapeutic target for the development of new anti‐HCC drugs. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5362349 Tue, 01 Nov 2011 04:00:00 +0100 5362349 http://www.medworm.com/index.php?rid=5336873&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02667.x AbstractDuring recent years, there was a great development in the area of hepatocellular adenomas (HCA), especially regarding the pathological subtype classification, radiological imaging and management during pregnancy. This review discusses the current knowledge about diagnosis and treatment modalities of HCA and proposes a decision‐making model for HCA. A Medline search of studies relevant to epidemiology, histopathology, complications, imaging and management of HCA lesions was undertaken. References from identified articles were hand‐searched for further relevant articles. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5336873 Sat, 22 Oct 2011 10:12:11 +0100 5336873 http://www.medworm.com/index.php?rid=5336875&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02669.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5336875 Thu, 20 Oct 2011 04:00:00 +0100 5336875 http://www.medworm.com/index.php?rid=5336874&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02646.x ConclusionsThese data show that Yap induction mediated by inactivation of Lats is observed in hepatic malignancies. These studies highlight Hippo kinase pathway as a novel therapeutic target for hepatic malignancies. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5336874 Thu, 20 Oct 2011 04:00:00 +0100 5336874 http://www.medworm.com/index.php?rid=5336876&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02670.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5336876 Wed, 19 Oct 2011 04:00:00 +0100 5336876 http://www.medworm.com/index.php?rid=5324525&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02665.x ConclusionsSerum suPAR is a potential novel biomarker for the diagnosis of cirrhosis, identification of alcoholic origin and for determining prognosis in patients with chronic liver disease. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5324525 Tue, 18 Oct 2011 10:26:28 +0100 5324525 http://www.medworm.com/index.php?rid=5324528&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02661.x DiscussionMale patients with very low Cp serum concentrations showed slightly elevated median serum ferritin concentrations, probably related to lack of ferroxidase acitivity. However, in consideration of absolute numbers of ferritin concentrations, these changes seem to be of minor clinical relevance. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5324528 Mon, 17 Oct 2011 04:00:00 +0100 5324528 http://www.medworm.com/index.php?rid=5324527&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02662.x ConclusionThe concentrations of cytotoxic BAs are insufficient to cause hepatocellular injury. In contrast, TCA, βMCA and TβMCA are able to induce pro‐inflammatory mediators in hepatocytes. Thus, BAs act as inflammagens and not as cytotoxic mediators after BDL in mice. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5324527 Mon, 17 Oct 2011 04:00:00 +0100 5324527 http://www.medworm.com/index.php?rid=5324526&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02663.x ConclusionFor the diagnosis of fibrosis stages F ≤ 2 TE is suboptimal, and inflammation may induce higher values. For stages F ≥ 3 TE performance is good and equal in both CHB and CHC patients. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5324526 Mon, 17 Oct 2011 04:00:00 +0100 5324526 http://www.medworm.com/index.php?rid=5316173&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02657.x ConclusionsHigh density lipoprotein levels are low in patients with liver failure and reflect its severity. Levels are lower in non‐survivors but do not offer an advantage as early indicators of prognosis over conventional markers. No evidence of a major predisposing role for infection was found, but findings suggest a close link to adrenal function. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5316173 Sat, 15 Oct 2011 08:54:52 +0100 5316173 http://www.medworm.com/index.php?rid=5305091&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02655.x AbstractHypoxic hepatitis (HH), an acute liver injury also known as ‘ischaemic hepatitis’ or ‘shock liver’, is frequently observed in intensive care units. HH is heralded by a massive but transient rise in serum aminotransferase activities caused by anoxic necrosis of centrilobular liver cells. Cardiac failure, respiratory failure and toxic‐septic shock are the main underlying conditions accounting for more than 90% of cases, but HH may also occur in other circumstances. Until recently, liver ischaemia, i.e. a drop in hepatic blood flow, was considered the leading, and even the sole, hemodynamic mechanism responsible for HH, and it was generally held that a shock state was required. In reality, other hemodynamic mechanisms of hypoxia, such as passive congestion of the liver, arte... Liver International journals http://www.medworm.com/rss/comments.php?id=5305091 Wed, 12 Oct 2011 08:29:33 +0100 5305091 http://www.medworm.com/index.php?rid=5286394&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02653.x ConclusionIL28B rs12979860 and rs8099917 polymorphisms were predictors of therapy response in HCV genotypes 1, 2 and 3 subjects from an admixed population. Genomic ancestry did not interfere with response to therapy in patients with rs12979860 C/C, whereas it interfered in patients with C/T and T/T genotypes. Among HCV genotype 1 rs8099917 T/T patients, genomic ancestry interfered with response to therapy. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5286394 Mon, 03 Oct 2011 04:00:00 +0100 5286394 http://www.medworm.com/index.php?rid=5286393&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02651.x ConclusionsThe administration of vitamin E suppressed hepatic ADMA and oxidative stress in the cirrhotic liver circulation, and therefore increases NO bioavailability, which improved HED and portal hypertension. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5286393 Sat, 01 Oct 2011 04:00:00 +0100 5286393 http://www.medworm.com/index.php?rid=5261515&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02656.x ConclusionThe aggregation of p62 is specifically increased in the damage bile ducts in PBC and may reflect dysfunctional autophagy, followed by cellular senescence in the pathogenesis of bile duct lesions in PBC. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5261515 Thu, 29 Sep 2011 08:18:33 +0100 5261515 http://www.medworm.com/index.php?rid=5261518&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02648.x ConclusionsThe genetic polymorphisms IVS4‐81G/A in MTA1 and +12916C in VEGF genes were correlated with MTA1 overexpression. The SNPs in MTA1 and IGF‐II genes may be important risk factors for the recurrence of HCC. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5261518 Mon, 26 Sep 2011 04:00:00 +0100 5261518 http://www.medworm.com/index.php?rid=5261517&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02650.x ConclusionsRifaximin improves cirrhosis‐related thrombocytopenia and this could be related with the reduction of endotoxaemia. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5261517 Mon, 26 Sep 2011 04:00:00 +0100 5261517 http://www.medworm.com/index.php?rid=5261516&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02652.x ConclusionWe found that the HCV‐specific T‐cell responses were associated with good viral control in patients with combination therapy. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5261516 Mon, 26 Sep 2011 04:00:00 +0100 5261516 http://www.medworm.com/index.php?rid=5261519&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02654.x ConclusionsThese findings indicate the involvement of NK and NKT cells as well as T lymphocytes CD4+ and CD8+ in the inflammatory process inducing FHF, confirmed by the high hepatic expression of IFN‐γ. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5261519 Sun, 25 Sep 2011 04:00:00 +0100 5261519 http://www.medworm.com/index.php?rid=5238816&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02641.x ConclusionFive years of ADV treatment in Chinese subjects with HBeAg‐positive CHB resulted in increasing virological and serological responses and sustained biochemical responses over time. Virological resistance was identified in 14.6% of patients. Urgent switch or add‐on therapy with a nucleoside analogue is necessary if ADV resistant mutations are detected, particularly rtN236T. Treatment was well tolerated. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5238816 Thu, 22 Sep 2011 10:11:03 +0100 5238816 http://www.medworm.com/index.php?rid=5226948&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02635.x ConclusionInappropriate innate immune responses to intestinal endotoxins and subsequent endotoxin intolerance because of enhanced PRR signalling in BECs probably contribute to chronic cholangitis. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5226948 Mon, 19 Sep 2011 01:34:17 +0100 5226948 http://www.medworm.com/index.php?rid=5226949&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02643.x ConclusionAlthough surgical interventions and blood transfusion are significant risk factors for HCV acquisition in Egyptian children, dental treatment remains the highest risk factor for HCV chronic persistence in children. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5226949 Thu, 15 Sep 2011 04:00:00 +0100 5226949 http://www.medworm.com/index.php?rid=5226951&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02647.x ConclusionBiochemical response at 12 months from baseline was better in patients with a rtM204I mutation than rtM204V+ rtM204I/V mutations. In addition, early treatment failure was more common in patients with rtM204V+ rtM204I/V mutations than a rtM204I mutation. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5226951 Wed, 14 Sep 2011 04:00:00 +0100 5226951 http://www.medworm.com/index.php?rid=5226950&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02642.x ConclusionTogether, these data suggest that somatostatin stimulates the migration of HOC within injured liver through SSTR4, and this action appears to be mediated by the PI3K pathway. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5226950 Wed, 14 Sep 2011 04:00:00 +0100 5226950 http://www.medworm.com/index.php?rid=5226952&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02640.x ConclusionsHCCs expressing progenitor cell markers can be characterized according to their non‐expanding MR gross morphology, persistent or progressive dynamic enhancement patterns, higher SIRs on DWIs, lower SIRs on hepatobiliary phase images and less frequent nodule‐in‐nodule appearance. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5226952 Tue, 13 Sep 2011 04:00:00 +0100 5226952 http://www.medworm.com/index.php?rid=5209859&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02633.x ConclusionAlthough HCV can lead to liver transplantation and death during childhood, the vast majority of patients with disease acquired during childhood have slowly progressive disease. There is no clear indication for antiviral therapy in the majority of children with HCV infection. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5209859 Mon, 12 Sep 2011 23:08:26 +0100 5209859 http://www.medworm.com/index.php?rid=5209860&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02644.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5209860 Sun, 11 Sep 2011 04:00:00 +0100 5209860 http://www.medworm.com/index.php?rid=5209864&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02639.x ConclusionThe N/L ratio is higher in patients with NASH and advanced fibrosis. This ratio can be used as a novel noninvasive marker to predict advanced disease. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5209864 Thu, 08 Sep 2011 04:00:00 +0100 5209864 http://www.medworm.com/index.php?rid=5209863&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02630.x ConclusionsAntibodies to the β‐ and γ‐subunits of F1‐ATPase are further AMAs in PBC but occur also in other autoimmune liver disorders; they may be, therefore, indicators for a general autoimmune process of the liver. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5209863 Thu, 08 Sep 2011 04:00:00 +0100 5209863 http://www.medworm.com/index.php?rid=5209862&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02637.x ConclusionsLow serum levels of GH and DHEA are very common in patients with NASH with more advanced fibrosis. Other biomarkers, including CK‐18 fragment levels, have predictivity characteristics that would be of low clinical utility for distinguishing patients with normal histology or SS from those with NASH. These findings demonstrate an endocrine profile associated with advanced fibrosis. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5209862 Thu, 08 Sep 2011 04:00:00 +0100 5209862 http://www.medworm.com/index.php?rid=5209861&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02638.x ConclusionsSerum total and free 25(OH)D and DBP concentrations rose substantially following transplantation, while 1,25(OH)2D concentrations showed modest changes and free 1,25(OH)2D decreased. Studies of the effects of vitamin D status on diverse transplant complications are needed. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5209861 Thu, 08 Sep 2011 04:00:00 +0100 5209861 http://www.medworm.com/index.php?rid=5196935&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02577.x Conclusions: Fecal calprotectin concentrations serve as a screening tool for HE and SBP. Assessment of FCCs may faciliate grading of HE‐severity. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5196935 Wed, 07 Sep 2011 03:29:36 +0100 5196935 http://www.medworm.com/index.php?rid=5196932&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02618.x ConclusionSevere HE mainly affects LOS, and this association is independent of MELD. Whether the large changes in peri‐LT serum Na, more frequently seen in the severe HE group, contribute to post‐LT morbidity requires further study. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5196932 Wed, 07 Sep 2011 03:28:53 +0100 5196932 http://www.medworm.com/index.php?rid=5238817&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02631.x ConclusionsEnhanced growth inhibition in hepatoma cells treated with both NSC 74859 and cetuximab suggests that cetuximab resistance is probably mediated via STAT3. Combination therapy using both inhibitors of EGFR and STAT3 signalling warrants further investigation under in vivo condition. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5238817 Tue, 06 Sep 2011 04:00:00 +0100 5238817 http://www.medworm.com/index.php?rid=5196934&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02649.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5196934 Mon, 05 Sep 2011 23:00:00 +0100 5196934 http://www.medworm.com/index.php?rid=5196933&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02631.x ConclusionsEnhanced growth inhibition in hepatoma cells treated with both NSC 74859 and cetuximab suggests that cetuximab resistance is probably mediated via STAT3. Combination therapy using both inhibitors of EGFR and STAT3 signalling warrants further investigation under in vivo condition. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5196933 Mon, 05 Sep 2011 23:00:00 +0100 5196933 http://www.medworm.com/index.php?rid=5184749&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02623.x ConclusionsIn morbid obese patients, NASH, particularly lobular inflammation and advanced fibrosis, associates with mild decreases in eGFR, suggesting a common inflammatory link between liver and renal lesion. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5184749 Wed, 31 Aug 2011 23:00:00 +0100 5184749 http://www.medworm.com/index.php?rid=5184753&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02629.x AbstractCirrhosis is a major cause of morbidity and mortality and is the end stage of any chronic liver disease. Cancer, a leading cause of death worldwide, is a growing global health issue. There are limited data in the literature on the incidence, prevalence and management of non‐hepatic cancers (NHC) in cirrhotic patients. The aim of this brief review was to underline the main concerns, pitfalls and warnings regarding practice for these patients.Survival of patients with compensated cirrhosis is significantly longer than that of decompensated cirrhosis and patients with NHC and in Child‐Pugh class C should not be candidates for cytotoxic chemotherapy. It is important before starting cytotoxic chemotherapy to assess the aetiology and stage of liver disease and to screen these patient... Liver International journals http://www.medworm.com/rss/comments.php?id=5184753 Mon, 29 Aug 2011 23:00:00 +0100 5184753 http://www.medworm.com/index.php?rid=5184752&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02603.x AbstractAutoimmune hepatitis (AIH) is an important entity within the broad spectrum of autoimmune hepatobiliary disease comprised of AIH, primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). Since the 1960s, AIH has been investigated with extensive clinical research aimed at effective therapeutic intervention. It was one of the first liver diseases where treatment was demonstrated to prolong survival. AIH occurs in children, as well as in adults. Its clinical manifestations in children may differ from classic adult AIH. These differences have elucidated certain aspects of AIH and hepatobiliary disease in general. There are two major patterns of AIH: type 1, with anti‐smooth muscle antibodies and type 2, with anti‐liver/kidney microsomal antibodies. The second type ... Liver International journals http://www.medworm.com/rss/comments.php?id=5184752 Mon, 29 Aug 2011 23:00:00 +0100 5184752 http://www.medworm.com/index.php?rid=5184751&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02634.x ConclusionThis study provides evidence that commencement of antiviral therapy during the surveillance period is associated with improvement in overall survival in HBV‐related HCC. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5184751 Mon, 29 Aug 2011 23:00:00 +0100 5184751 http://www.medworm.com/index.php?rid=5184750&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02632.x ConclusioncPLA2α‐mediated induction of PPAR‐β/δ is a novel intracellular signalling pathway in spontaneous and TGF‐β induced activation of HSCs and could be a potential therapeutic target for the treatment of liver fibrosis. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5184750 Mon, 29 Aug 2011 23:00:00 +0100 5184750 http://www.medworm.com/index.php?rid=5163058&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02628.x ConclusionsThe syncytial H6‐Luc virus has a strong oncolytic potential on human HCC xenografts and could be the basis for potent OV. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5163058 Sat, 27 Aug 2011 16:05:23 +0100 5163058 http://www.medworm.com/index.php?rid=5163061&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02627.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5163061 Wed, 24 Aug 2011 23:00:00 +0100 5163061 http://www.medworm.com/index.php?rid=5163060&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02614.x ConclusionsPrimary sclerosing cholangitis was associated with a four‐fold increase in mortality in this population‐based study. In accordance with previous studies, the risk of hepatobiliary cancer was dramatically increased. However, the increased risk of colorectal cancer reported in previous studies could not be confirmed. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5163060 Wed, 24 Aug 2011 23:00:00 +0100 5163060 http://www.medworm.com/index.php?rid=5163059&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02625.x DiscussionHigher mRNA levels of HSP70 in the low bilirubin group could indicate a possible protective effect of high HSP70 levels against IR injury. Although the exact role of hepatobiliary transport systems in the development of post‐operative hyper bilirubinemia is not yet completely understood, this study provides new insights into the molecular aspects of post‐operative jaundice after liver surgery. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5163059 Wed, 24 Aug 2011 23:00:00 +0100 5163059 http://www.medworm.com/index.php?rid=5144702&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02624.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5144702 Sat, 20 Aug 2011 16:35:53 +0100 5144702 http://www.medworm.com/index.php?rid=5144705&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02626.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5144705 Tue, 16 Aug 2011 23:00:00 +0100 5144705 http://www.medworm.com/index.php?rid=5144704&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02607.x AbstractPatients suffering from primary sclerosing cholangitis (PSC) show considerable differences regarding clinical manifestations (i.e. large duct versus small‐duct PSC, presence or absence of concomitant inflammatory bowel disease), disease progression, risk for malignancy and response to therapy, raising the question whether PSC may represent a mixed bag of diseases of different aetiologies. The growing list of secondary causes and diseases ‘mimicking’ or even overlapping with PSC (e.g. IgG4‐associated sclerosing cholangitis), which frequently causes problems in clear‐cut discrimination from classic PSC and the emerging knowledge about potential disease modifier genes (e.g. variants of CFTR, TGR5 and MDR3) support such a conceptual view. In addition, PSC in children differs ... Liver International journals http://www.medworm.com/rss/comments.php?id=5144704 Tue, 16 Aug 2011 23:00:00 +0100 5144704 http://www.medworm.com/index.php?rid=5144703&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02620.x AbstractHereditary haemochromatosis (HH), which is mainly associated with a C282Y polymorphism in HFE, is common among Caucasians of north European descent, but is very rare among Asians. Herein, we report a 43‐year‐old Japanese man who was diagnosed as having HH. A laboratory examination revealed an elevated serum iron level (280 μg/dl), hyperferritinemia (1698 ng/ml) and a low serum level of hepcidin‐25 (4.0 ng/ml). Abdominal magnetic resonance imaging revealed findings suggestive of iron accumulation in the liver and pancreas. HFE gene sequencing in the patient revealed a novel homozygous TAC nucleotide deletion (c. 691_693del) responsible for the loss of a tyrosine at position 231 (p. Y231del) of the HFE protein. This homozygous Y231del mutation was recently found in the Huh�... Liver International journals http://www.medworm.com/rss/comments.php?id=5144703 Tue, 16 Aug 2011 23:00:00 +0100 5144703 http://www.medworm.com/index.php?rid=5132792&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02598.x ConclusionsThese data suggest that previous bouts of HE, despite their complete clinical resolution, play an independent role in producing a persistent impairment in HRQoL of cirrhotics. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5132792 Tue, 16 Aug 2011 22:35:29 +0100 5132792 http://www.medworm.com/index.php?rid=5126822&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02611.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5126822 Sun, 14 Aug 2011 01:28:17 +0100 5126822 http://www.medworm.com/index.php?rid=5126825&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02616.x ConclusionsAdefovir and lamivudine combination therapy is not an independent factor for significant renal dysfunction in HBeAg‐negative patients with lamivudine‐resistance. Baseline age and creatinine clearance are the only independent predictors of worsening renal function. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5126825 Wed, 10 Aug 2011 23:00:00 +0100 5126825 http://www.medworm.com/index.php?rid=5126824&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02619.x ConclusionsPLOD2 is a potential novel prognostic factor for HCC patients following surgery. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5126824 Wed, 10 Aug 2011 23:00:00 +0100 5126824 http://www.medworm.com/index.php?rid=5126823&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02621.x ConclusionsHonokiol inhibits HCV infection by targeting cell entry and replication and, only at a concentration >30 μM, IRES‐mediated translation of HCV life cycle. Based on its high therapeutic index (LD50/EC90 = 5.4), honokiol may be a promising drug for the treatment of HCV infection. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5126823 Wed, 10 Aug 2011 23:00:00 +0100 5126823 http://www.medworm.com/index.php?rid=5110451&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02592.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5110451 Wed, 10 Aug 2011 18:12:00 +0100 5110451 http://www.medworm.com/index.php?rid=5110449&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02609.x Conclusions:These data suggest that steatotic livers, discarded for orthotopic liver transplantation and hepatocyte isolation, could be a suitable source for large scale isolation of HPC which might be potential candidates in liver cell therapy. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5110449 Wed, 10 Aug 2011 18:11:57 +0100 5110449 http://www.medworm.com/index.php?rid=5110441&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02613.x ConclusionsOccult HCV infection persists over time with fluctuating viraemia levels that induce and maintain specific T‐cell responses against viral proteins. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5110441 Wed, 10 Aug 2011 18:11:13 +0100 5110441 http://www.medworm.com/index.php?rid=5110444&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02601.x ConclusionIn these HBV/HIV‐co‐infected patients, first‐line HBV therapy with tenofovir and emtricitabine or lamivudine was associated with EVR. However, DR to tenofovir was observed in 15% of patients who added tenofovir to lamivudine therapy, of whom four of seven (57%) had genotype G‐HBV infection. No resistance was evidenced after 46 months of therapy even in patients with DR to tenofovir. At last, a good renal safety profile of TDF was observed after a median follow‐up of 4 years of therapy. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5110444 Mon, 08 Aug 2011 23:00:00 +0100 5110444 http://www.medworm.com/index.php?rid=5110443&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02612.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5110443 Mon, 08 Aug 2011 23:00:00 +0100 5110443 http://www.medworm.com/index.php?rid=5110442&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02622.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5110442 Mon, 08 Aug 2011 23:00:00 +0100 5110442 http://www.medworm.com/index.php?rid=5110448&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02599.x Conclusions:Because normalisation of IGF‐I levels did not affect insulin sensitivity lack of IGF‐I is unlikely to result in insulin resistance in cirrhosis. IGF‐I supplementation is therefore unlikely to improve insulin action in patients with cirrhosis. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5110448 Sat, 06 Aug 2011 23:00:00 +0100 5110448 http://www.medworm.com/index.php?rid=5110447&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02578.x Conclusion: We suggest that the acronym ‘BASM’ be redefined as ‘biliary atresia structural malformation’. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5110447 Sat, 06 Aug 2011 23:00:00 +0100 5110447 http://www.medworm.com/index.php?rid=5110446&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02605.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5110446 Sat, 06 Aug 2011 23:00:00 +0100 5110446 http://www.medworm.com/index.php?rid=5110445&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02617.x Conclusions:This study provides evidence that in cirrhosis, platelet isoprostanes are over‐produced and could be implicated in platelet activation. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5110445 Sat, 06 Aug 2011 23:00:00 +0100 5110445 http://www.medworm.com/index.php?rid=5098518&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02596.x Conclusions: Hras‐associated hepatocyte growth deregulation is not complemented by activation of c‐myc or TGFα growth signalling pathways in mouse liver. This finding emphasizes the tissue‐specific character of molecular growth regulation. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5098518 Wed, 03 Aug 2011 23:00:00 +0100 5098518 http://www.medworm.com/index.php?rid=5098517&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02597.x Conclusions:Serum and tissue DKK1 levels increased in a stepwise manner in multistep hepatocarcinogenesis and had prognostic significance. DKK1 plays a functional role in cell migration, invasion and tumour growth. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5098517 Wed, 03 Aug 2011 23:00:00 +0100 5098517 http://www.medworm.com/index.php?rid=5098516&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02600.x Conclusions:Liver autoimmune response can be initiated using molecular mimicry over a long period of time, validating the hit‐and‐run hypothesis. Initial liver inflammatory injury is neither necessary, nor detrimental to the development of AIH. These results highlight the significance of initial events on the pathogenesis of autoimmune liver injury. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5098516 Wed, 03 Aug 2011 23:00:00 +0100 5098516 http://www.medworm.com/index.php?rid=5098515&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02615.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5098515 Sun, 31 Jul 2011 23:00:00 +0100 5098515 http://www.medworm.com/index.php?rid=5089046&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02602.x Conclusions:Carnitine and carnitine‐lipoic acid prevent lipotoxicity by increasing mitochondrial β‐oxidation and reducing intracellular oxidative stress. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5089046 Sun, 31 Jul 2011 23:00:00 +0100 5089046 http://www.medworm.com/index.php?rid=5080541&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02608.x AbstractCell death by apoptosis is a prominent feature in a variety of liver diseases. It is likely that apoptosis is the initial cellular response to hepatocyte and biliary injury, which then leads to the initiation of cellular and cytokine cascades culminating in hepatocyte death with subsequent fibrosis and cirrhosis. This sequence of events is of paramount clinical importance. Recently, soluble forms of the major histocompatibility complex class I‐related chains A and closely related B (MIC A and B) were reported to be increased in patients with a variety of liver diseases. MIC A and B are cell surface glycoproteins that function as indicators for cellular stress and thus activate circulating cytotoxic natural killer (NK) cells. The interaction between MIC A and B with their cognate ... Liver International journals http://www.medworm.com/rss/comments.php?id=5080541 Sun, 31 Jul 2011 23:00:00 +0100 5080541 http://www.medworm.com/index.php?rid=5080544&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02604.x AbstractOxidative stress is commonly associated with a number of liver diseases and is thought to play a role in the pathogenesis of chronic hepatitis C, alcoholic liver disease, non‐alcoholic steatohepatitis (NASH), haemochromatosis and Wilson's disease. Antioxidant therapy has thus been considered to have the possibility of beneficial effects in the management of these liver diseases. Despite this promise, antioxidants have produced mixed results in a number of clinical trials of efficacy. This review summarizes the results of clinical trials of antioxidants as sole or adjuvant therapy of chronic hepatitis C, alcoholic liver disease and non‐alcoholic steatohepatitis (NASH). Overall, the most promising results to date are for vitamin E therapy of NASH but some encouraging results have... Liver International journals http://www.medworm.com/rss/comments.php?id=5080544 Thu, 28 Jul 2011 23:00:00 +0100 5080544 http://www.medworm.com/index.php?rid=5080543&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02610.x ConclusionsAberrant expressions of AQP1 in periportal sinusoidal regions in human cirrhotic liver indicate the proliferation of arterial capillaries directly connected to the sinusoids, contributing to microvascular resistance in cirrhosis. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5080543 Thu, 28 Jul 2011 23:00:00 +0100 5080543 http://www.medworm.com/index.php?rid=5080542&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02606.x We report a case of inadvertent transplantation of a liver from a haemochromatosis donor to a 56‐year‐old Asian female. Progressive iron overload occurred over a 2 year follow up as assessed by liver biopsy and iron studies in the absence of a secondary cause of iron overload, supporting a primary role of liver rather than small intestine in the regulation of iron homeostasis in hereditary haemochromatosis. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5080542 Thu, 28 Jul 2011 23:00:00 +0100 5080542 http://www.medworm.com/index.php?rid=5040648&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02591.x Conclusions: We confirmed that in patients with cirrhosis, the development of HPS is associated with higher cardiac output and hyperdynamic circulation. Left ventricle enlargement and higher systolic velocity in the mitral valve represent satisfactory indirect markers of HPS. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5040648 Wed, 20 Jul 2011 17:54:03 +0100 5040648 http://www.medworm.com/index.php?rid=5031144&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02593.x Conclusion: We suggest that cellular HDV‐specific immune responses contribute to the control of HDV infection and that cytokine responses may indicate response to type‐I‐IFN‐based antiviral therapy of hepatitis delta. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5031144 Sat, 16 Jul 2011 17:08:09 +0100 5031144 http://www.medworm.com/index.php?rid=5031145&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02590.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5031145 Tue, 12 Jul 2011 23:00:00 +0100 5031145 http://www.medworm.com/index.php?rid=5010456&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02565.x (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=5010456 Sat, 09 Jul 2011 20:26:09 +0100 5010456 http://www.medworm.com/index.php?rid=4999810&cid=s_30389_17_f&fid=30389&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1478-3231.2011.02575.x Conclusions: Since the use of transplantation, malignancies are the major cause of death. CCa has to be searched for in any new symptomatic patient. Colorectal malignancy occurs frequently. Colonoscopy at the diagnosis of PSC is obligatory and should be repeated at 1–2 years interval in the patients with IBD and every 5 years in those without IBD. (Source: Liver International) Liver International journals http://www.medworm.com/rss/comments.php?id=4999810 Mon, 04 Jul 2011 23:00:00 +0100 4999810