MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Lung Cancer' source. Wed, 08 Feb 2012 08:41:47 +0100 http://www.medworm.com/index.php?rid=5666804&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500212000499%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666804 Wed, 08 Feb 2012 13:23:50 +0100 5666804 http://www.medworm.com/index.php?rid=5666803&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500212000475%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666803 Wed, 08 Feb 2012 13:23:50 +0100 5666803 http://www.medworm.com/index.php?rid=5581109&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211006635%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581109 Fri, 13 Jan 2012 13:20:46 +0100 5581109 http://www.medworm.com/index.php?rid=5581108&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211006611%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581108 Fri, 13 Jan 2012 13:20:46 +0100 5581108 http://www.medworm.com/index.php?rid=5666812&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004296%2Fabstract%3Frss%3Dyes Conclusions: Both EGFR and K-ras mutations frequently occur randomly in multifocal lung adenocarcinomas. Combined mutation pattern analyses of EGFR and K-ras may be useful for making decisions regarding treatment strategies for patients with multifocal lung adenocarcinomas. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666812 Fri, 30 Dec 2011 05:00:00 +0100 5666812 http://www.medworm.com/index.php?rid=5494711&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211006258%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494711 Tue, 13 Dec 2011 01:58:54 +0100 5494711 http://www.medworm.com/index.php?rid=5494710&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211006234%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494710 Tue, 13 Dec 2011 01:58:54 +0100 5494710 http://www.medworm.com/index.php?rid=5494732&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100585X%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494732 Wed, 07 Dec 2011 05:00:00 +0100 5494732 http://www.medworm.com/index.php?rid=5494731&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211005769%2Fabstract%3Frss%3Dyes We wish to add some comments regarding the recent article written by Vergnenègre et al. entitled “Multicenter observational study of erlotinib therapy (OBSTAR) for non small-cell lung cancer: a GFPC study”. It would be very interesting to analyse treatments after erlotinib in addition to the chemotherapy before erlotinib as we have found in our pilot study a strong correlation between post erlotinib chemotherapy and prolonged OS. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494731 Fri, 02 Dec 2011 05:00:00 +0100 5494731 http://www.medworm.com/index.php?rid=5494730&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211005757%2Fabstract%3Frss%3Dyes We report the case of a 61-year-old man with non-small lung cancer with poorly controlled type 2 diabetes mellitus who developed clinically significant hypoglycaemia secondary to a first exposure to granulocyte colony stimulating factor (G-CSF) injections. Whilst artefactual hypoglycaemia during treatment with G-CSF is well recognised, to our knowledge, this is the first report revealing that it can provoke true hypoglycaemia in the absence of leucocytosis. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494730 Tue, 29 Nov 2011 05:00:00 +0100 5494730 http://www.medworm.com/index.php?rid=5666824&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100523X%2Fabstract%3Frss%3Dyes Conclusion: Erlotinib-associated ILD is a rare, serious and often fatal adverse reaction. Most likely, the cause for erlotinib-associated ILD is multifactorial and high drug levels may be present in patients without serious adverse reactions. However, considering the pharmacology of EGFR inhibitors, high drug and metabolite levels may play a role and future studies are warranted to identify risk factors and to investigate the role of elevated levels of erlotinib and its metabolites in the development of pulmonary toxicity. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666824 Mon, 21 Nov 2011 05:00:00 +0100 5666824 http://www.medworm.com/index.php?rid=5400325&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211005630%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400325 Sun, 13 Nov 2011 01:54:35 +0100 5400325 http://www.medworm.com/index.php?rid=5400324&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211005617%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400324 Sun, 13 Nov 2011 01:54:35 +0100 5400324 http://www.medworm.com/index.php?rid=5581111&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004788%2Fabstract%3Frss%3Dyes Abstract: Tumor hypoxia has been found to be a characteristic feature in lung cancer. It has been shown to decrease the therapeutic efficacy of radiotherapy and some forms of chemotherapy. New methods for qualitative and quantitative assessment of tumor oxygenation have made it possible to establish the prognostic significance of tumor hypoxia. The ability to determine the degree and extent of hypoxia in lung cancer is not only important prognostically, but also in the selection of patients for hypoxia-modifying treatments. To provide the best attainable quality of life for individual patients it is of increasing importance that tools be developed that allow a better selection of patients for these intensified treatment strategies. Although some markers and combinations have shown potentia... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581111 Mon, 17 Oct 2011 04:00:00 +0100 5581111 http://www.medworm.com/index.php?rid=5314025&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211005101%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314025 Sat, 15 Oct 2011 01:02:50 +0100 5314025 http://www.medworm.com/index.php?rid=5314024&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211005083%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314024 Sat, 15 Oct 2011 01:02:50 +0100 5314024 http://www.medworm.com/index.php?rid=5666811&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004387%2Fabstract%3Frss%3Dyes Conclusions: IHC discriminated more effectively than qRT-PCR across four NSCLC-relevant biomarkers. The findings are further supported by the demonstrated lack of correlation between transcript and protein. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666811 Fri, 14 Oct 2011 04:00:00 +0100 5666811 http://www.medworm.com/index.php?rid=5666805&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100479X%2Fabstract%3Frss%3Dyes Abstract: Despite the fact that Non-Small Cell Lung Cancer (NSCLC) represents the leading cause of cancer-related death in the western, after two decades of intensive clinical research, there still remains a substantial lack of consensus regarding the appropriate chemotherapeutic management of patients with advanced stage disease.For patients with metastatic disease and good performance status, what is considered “standard” treatment is a platinum-based doublet. Several meta-analyses have been performed in order to answer several questionable issues in the treatment of these patients. Their conclusions could be used as an effective instrument for resolving various clinical questions, such as advantage of chemotherapy for advanced NSCLC and identification of the most active combinations... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666805 Thu, 13 Oct 2011 04:00:00 +0100 5666805 http://www.medworm.com/index.php?rid=5400357&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100482X%2Fabstract%3Frss%3Dyes We read with interest Sahoo and colleagues’ recent paper on the prevalence of Epidermal Growth Factor Receptor (EGFR) mutations in India. We commend the authors on reporting the first relatively large series of patients who underwent EGFR mutation testing in India. There has been renewed interest in EGFR testing with unequivocal results that response to tyrosine kinase inhibitors (TKI) depended on the presence of these mutations . Previous studies had reported a relatively higher incidence of EGFR mutations in ‘Asian’ compared to Caucasian populations – these, however, had patients from various countries within Asia, and were hence inhomogeneous. Limited availability of EGFR testing in the initial years combined with relatively high costing in subsequent years meant that very few c... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400357 Thu, 13 Oct 2011 04:00:00 +0100 5400357 http://www.medworm.com/index.php?rid=5666809&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004673%2Fabstract%3Frss%3Dyes Abstract: Accurate distinction of lung cancer types has become increasingly important as recent trials have shown differential response to chemotherapy among non-small cell lung carcinoma (NSCLC) subtypes. Cytological procedures are frequently used but their diagnostic accuracy has been previously questioned. However, new endoscopic and cytological techniques might have improved cytological accuracy in comparison with prior findings. The aim of this study was to reassess cytological accuracy for diagnosis of lung cancer subtypes. A retrospective chart review of subjects who underwent fiberoptic bronchoscopy (FOB) for suspicion of lung cancer in 2007–2008, was undertaken. Reports of bronchoscopically derived cytological specimens were compared to those of histological material. Endoscopic... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666809 Wed, 05 Oct 2011 04:00:00 +0100 5666809 http://www.medworm.com/index.php?rid=5666806&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004363%2Fabstract%3Frss%3Dyes We examined 297 female lung cancer cases and 1188 controls. The unadjusted odds ratios (ORs) for any statin prescription were 0.78 (95% confidence interval=0.57–1.07) and the adjusted OR was 0.82 (95% CI=0.58–1.15). Compared with no use of statins, the adjusted ORs were 0.83 (95% CI=0.54–1.28) for the group having been prescribed statins with cumulative defined daily dose (DDDs) below 92.41 and 0.79 (95% CI=0.50–1.25) for the group with cumulative statin use of 92.41 DDDs or more. The present data do not provide support for a beneficial association between statin use and female lung cancer risk. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666806 Wed, 28 Sep 2011 04:00:00 +0100 5666806 http://www.medworm.com/index.php?rid=5400356&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004351%2Fabstract%3Frss%3Dyes Conclusion: The European Medicine Agency grants marketing of drugs in all Europe, regulatory agency of each country can register the drug, but can also deny public reimbursement thus restricting the options of the oncologist. The European Oncology Associations should join to their effort to achieve a uniform access to the cancer therapy for all patients in Europe. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400356 Wed, 28 Sep 2011 04:00:00 +0100 5400356 http://www.medworm.com/index.php?rid=5314058&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004375%2Fabstract%3Frss%3Dyes We report a case of breast metastasis from primary lung cancer, which was confirmed by the detection of the same epidermal growth factor receptor (EGFR) gene mutation. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314058 Mon, 26 Sep 2011 04:00:00 +0100 5314058 http://www.medworm.com/index.php?rid=5666816&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004399%2Fabstract%3Frss%3Dyes Conclusions: An RODP results in a timely diagnosis well within guideline recommendations. Patient and first line delay account for most of total patient delay. Within the limitations of this retrospective study, we found no association with disease stage or survival. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666816 Fri, 23 Sep 2011 04:00:00 +0100 5666816 http://www.medworm.com/index.php?rid=5666820&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004338%2Fabstract%3Frss%3Dyes Abstract: The pemetrexed-cisplatin chemotherapy is standard of care in first-line (FL) treatment of malignant pleural mesothelioma (MPM). The second-line (SL) chemotherapy is considered, but the optimal treatment has not been defined yet. The aim of this study was to evaluate the clinical outcomes of SL-therapy in a series of MPM-patients included in a retrospective multicenter database. Clinical records of MPM-patients who received SL-treatment from 1996 to 2008 were reviewed. Study endpoints were response, overall-survival (OS), and progression-free-survival (PFS) for SL, stratified for patient characteristics, FL-outcomes, and type of SL. Out of 423 patients, 181 with full clinical data were identified. Patients’ characteristics: median-age 64 years (range: 36–85); male gender 115 (... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666820 Wed, 21 Sep 2011 04:00:00 +0100 5666820 http://www.medworm.com/index.php?rid=5581130&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003850%2Fabstract%3Frss%3Dyes Conclusion: Raltitrexed plus cisplatin is a cost-effective first-line treatment for MPM. This conclusion was maintained across a number of sensitivity analyses. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581130 Wed, 21 Sep 2011 04:00:00 +0100 5581130 http://www.medworm.com/index.php?rid=5666821&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100434X%2Fabstract%3Frss%3Dyes Conclusion: The overall response rate to initial treatment and the survival outcomes of HGNEC-probable LCNEC were comparable to those of SCLC, but the effectiveness of second-line chemotherapy appeared to differ between the 2 groups. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666821 Mon, 19 Sep 2011 04:00:00 +0100 5666821 http://www.medworm.com/index.php?rid=5666814&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004314%2Fabstract%3Frss%3Dyes Conclusions: Molecular pattern recognition of exhaled breath can correctly distinguish patients with MPM from subjects with similar occupational asbestos exposure without MPM and from healthy controls. This suggests that breathprints obtained by electronic nose have diagnostic potential for MPM. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666814 Mon, 19 Sep 2011 04:00:00 +0100 5666814 http://www.medworm.com/index.php?rid=5666813&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004272%2Fabstract%3Frss%3Dyes Abstract: EGFR tyrosine kinase inhibitors (EGFR-TKIs) are recommended as first-line therapy in patients with advanced, recurrent, or metastatic non-squamous non-small cell lung cancer (NSCLC) that have active EGFR mutations. The importance of rapid and sensitive methods for the detection of EGFR mutations is emphasized. The aim of this study is to examine the EGFR mutational status by both direct DNA sequencing and peptide nucleic acid (PNA)-mediated real-time PCR clamping and to evaluate the correlation between the EGFR mutational status and the clinical response to EGFR-tyrosine kinase inhibitors. Clinical specimens from 240 NSCLC patients were analyzed for EGFR mutations in exons 18, 19, 20 and 21. All clinical data and tumor specimens were obtained from 8 centers of the Korean Molecula... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666813 Mon, 19 Sep 2011 04:00:00 +0100 5666813 http://www.medworm.com/index.php?rid=5666808&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004326%2Fabstract%3Frss%3Dyes This study was designed to determine whether ERα expression, estrogen levels, and endocrine disruptor exposure would influence tumor growth of lung adenocarcinoma cells using a xenograft model in which human lung adenocarcinoma cells with and without transgenic ERα expression were transplanted into female nude mice. Results showed that estrogen promoted tumor growth of ERα+ lung adenocarcinoma cells but inhibited that of ERα− lung adenocarcinoma cells. Endocrine disruptor benzo[a]pyrene stimulated ERα− tumor growth dose dependently. Either of ovariectomy and ERα expression abolished the tumor growth-promoting effect of benzo[a]pyrene. The high CYP1B1/CYP1A1 and low COMT/CYP1B1 expression ratios detected in ERα+ tumors suggested an accumulation of 4-hydroxyestradiol metabolite un... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666808 Mon, 19 Sep 2011 04:00:00 +0100 5666808 http://www.medworm.com/index.php?rid=5581110&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004211%2Fabstract%3Frss%3Dyes Abstract: Accurate delineation of the primary tumor and of involved lymph nodes is a key requisite for successful curative radiotherapy in non-small cell lung cancer (NSCLC). In recent years, it has become clear that the incorporation of FDG PET-CT scan information into the related processes of patient selection and radiotherapy planning has lead to significant improvements for patients with NSCLC. The use of FDG PET-CT information in radiotherapy planning allows better target volume definition, reduces inter-observer variability and encourages selective irradiation of involved mediastinal lymph nodes. PET-CT also opens the door for innovative radiotherapy delivery and the development of new concepts. However, care must be taken to avoid a variety of technical pitfalls and specific educati... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581110 Mon, 19 Sep 2011 04:00:00 +0100 5581110 http://www.medworm.com/index.php?rid=5314057&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004302%2Fabstract%3Frss%3Dyes We report a woman presenting with respiratory failure due to a right-sided pleural effusion, lung metastases and lymphangitis carcinomatosis from advanced lung adenocarcinoma in the third trimester of pregnancy, who showed good response to EGFR tyrosine kinase inhibitor. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314057 Mon, 19 Sep 2011 04:00:00 +0100 5314057 http://www.medworm.com/index.php?rid=5208089&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004636%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5208089 Mon, 12 Sep 2011 18:10:42 +0100 5208089 http://www.medworm.com/index.php?rid=5208088&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004612%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5208088 Mon, 12 Sep 2011 18:10:42 +0100 5208088 http://www.medworm.com/index.php?rid=5666818&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004284%2Fabstract%3Frss%3Dyes Abstract: This open label, single arm phase II study was designed to evaluate the efficacy and safety of the addition of cetuximab to first line chemotherapy with carboplatin and weekly docetaxel in patients with advanced non small-cell lung cancer (NSCLC). From February 2007 to December 2008 74 patients with NSCLC (stage IIIB and IV), ECOG PS ≤2 and no prior systemic chemotherapy were enrolled and treated with carboplatin (area under the curve=5 on day 1) and docetaxel (35mg/m2 on days 1, 8, and 15). Cycles were repeated every 4 weeks for a minimum of 4 and a maximum of 6 cycles. Cetuximab (400mg/m2 on day 1 with subsequent doses of 250mg/m2 weekly) was administered until progression or intolerable toxicity up to a maximum treatment duration of 12 months. The primary endpoint was the ov... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666818 Mon, 12 Sep 2011 04:00:00 +0100 5666818 http://www.medworm.com/index.php?rid=5666819&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004247%2Fabstract%3Frss%3Dyes Conclusions This large scale all case registry study appeared to have enrolled a major portion of Japanese MPM patients. Treatment with pemetrexed was generally well tolerated and showed safety and effectiveness comparable to prior clinical trials. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666819 Wed, 07 Sep 2011 04:00:00 +0100 5666819 http://www.medworm.com/index.php?rid=5666807&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004260%2Fabstract%3Frss%3Dyes Conclusion: The decrease in SCLC incidence rates may reflect decreases in the prevalence of cigarette smoking, and changes in the type of cigarettes smoked. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666807 Wed, 07 Sep 2011 04:00:00 +0100 5666807 http://www.medworm.com/index.php?rid=5400327&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003369%2Fabstract%3Frss%3Dyes Abstract: Because of increasing life expectancy and of higher risk of cancer with ageing, lung cancer in elderly is a frequent disease. For a long time nihilism influenced treatment decisions in elderly patients with advanced non-small cell lung cancer. Since the beginning of the last decade single agent chemotherapy has been accepted as standard of care, vinorelbine and gemcitabine being the most frequently used drugs in Europe and US, docetaxel in Japan.Platinum-based doublets have been shown to be superior to monotherapy in young and fit patients with advanced non-small cell lung cancer. Although there were some indications from subgroup analyses of clinical trials not specifically dedicated to elderly patients that a platinum-based doublet might also benefit to older patients, there wa... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400327 Wed, 07 Sep 2011 04:00:00 +0100 5400327 http://www.medworm.com/index.php?rid=5666815&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004235%2Fabstract%3Frss%3Dyes Abstract: Objective: To compare preoperative size of stage I and stage II lung adenocarcinoma as measured by Computed Tomography (CT) and as assessed on gross pathology specimens.Materials and methods: 47 patients diagnosed with stage I or II lung adenocarcinoma were evaluated. Institutional Review Board permission was obtained. Tumor contours were delineated using a semi-automated segmentation algorithm and adjusted based on a radiologist's input. Based on the tumor perimeter, maximal in-plane tumor diameter was calculated automatically. The largest single diameter from the pathology gross report was utilized. A paired t-test was used to examine the measurement difference between CT and pathology.Results: The mean largest diameter of the tumors at CT and pathology was 29.53mm and 24.04mm,... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666815 Mon, 05 Sep 2011 04:00:00 +0100 5666815 http://www.medworm.com/index.php?rid=5666822&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004259%2Fabstract%3Frss%3Dyes Abstract: Background: The predictive value of RRM1 to therapeutic efficacy of gemicitabine-containing chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC) remains disputable. This meta-analysis is performed to systematically evaluate whether RRM1 expression is associated with the clinical outcome of gemcitabine-containing regimen in advanced NSCLC.Methods: An electronic search was conducted using the databases Pubmed, Medline, EMBASE, Cochrane library and CNKI, from inception to May, 2011. A systemic review of the studies on the association between RRM1 expression in advanced NSCLC and clinical outcome of gemcitabine-containing regimen was performed. Pooled odds ratios (OR) for the response rate, weighted median survival and time to progression were calculated using th... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666822 Fri, 02 Sep 2011 04:00:00 +0100 5666822 http://www.medworm.com/index.php?rid=5400326&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003357%2Fabstract%3Frss%3Dyes Abstract: Adjuvant chemotherapy increases the 5-year survival rate of patients with completely resected non-small cell lung cancer (NSCLC) by absolute 5%. Molecular-targeted therapies and predictive biomarkers to select those patients who benefit hold promise to further improve the outcome. Several biomarkers including ERCC1, BRCA1, EGFR, or gene signatures have been characterized in retrospective analyses of adjuvant therapy trials. However, differences in trial design and laboratory tests might have affected the outcome and might explain discordant results. With regard to many biomarkers, laboratory tests for their assessment remain to be standardized. After standardization of these tests and further validation studies, biomarkers might allow individualizing adjuvant treatment in patient... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400326 Thu, 01 Sep 2011 04:00:00 +0100 5400326 http://www.medworm.com/index.php?rid=5581117&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003825%2Fabstract%3Frss%3Dyes Conclusion: Our results suggest that abnormality of the HGF/MET pathway occurs during the course of progression from non-invasive to invasive pulmonary adenocarcinoma. An increased MET gene copy number is indicative of a poor outcome in patients with small pulmonary adenocarcinomas. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581117 Mon, 29 Aug 2011 04:00:00 +0100 5581117 http://www.medworm.com/index.php?rid=5666823&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004223%2Fabstract%3Frss%3Dyes Conclusions: Diabetes was confirmed to be an independent predictor of the risk of LR following resection of NSCLC. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666823 Wed, 24 Aug 2011 04:00:00 +0100 5666823 http://www.medworm.com/index.php?rid=5494713&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100417X%2Fabstract%3Frss%3Dyes Abstract: Back ground: Although patients with stage IV non-small cell lung cancer (NSCLC) have a poor prognosis, a subset of patients with solitary brain or adrenal metastasis have more favorable outcome following surgical resection. Nevertheless, the outcome and predictive factors for survival following metastatectomy for patients with other metastatic sites are not well defined.Methods: We performed a systematic review using PUBMED database for all articles which included patients with NSCLC and solitary metastasis to sites other than the adrenal gland or the brain who had undergone resection of their metastasis and definitive treatment of the primary lung cancer. Potential prognostic factors on survival including age, sex, histology, T and N stage of the primary tumor, synchronous vs. m... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494713 Wed, 24 Aug 2011 04:00:00 +0100 5494713 http://www.medworm.com/index.php?rid=5666810&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100420X%2Fabstract%3Frss%3Dyes Conclusion: ALK rearrangement is strongly associated with ALK immunoreactivity, and was seen only in tumours with pure signet-ring morphology and solid growth pattern. Tumour morphology, growth pattern and ALK immunoreactivity appear to be good indicators of ALK rearrangement, with TTF-1 positivity aiding in proving primary pulmonary origin. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666810 Mon, 22 Aug 2011 04:00:00 +0100 5666810 http://www.medworm.com/index.php?rid=5666817&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004193%2Fabstract%3Frss%3Dyes Abstract: Purpose: To investigate the prognostic role of radical lymph node dissection in treatment for pulmonary Low Grade Malignant Tumors (LGMTs); specifically, on the extent of nodal removal and its impact on long-term survival.Methods: A total of 93 LGMTs cases underwent surgical resection and were histopathologically confirmed. Overall survival rates and disease-free survival were respectively calculated according to the extent of lymph node resection and histopathological grades of tumors. Risk factors of nodal involvement and survival predictors were calculated via multivariate analysis. Life table, Kaplan–Meier, and Cox regression models were used for the statistical analysis.Results: Thirty-eight cases of carcinoid, 17 adenoid cystic carcinomas, and 38 mucoepidermoid carcinomas... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5666817 Tue, 16 Aug 2011 04:00:00 +0100 5666817 http://www.medworm.com/index.php?rid=5581113&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003874%2Fabstract%3Frss%3Dyes Conclusion: The QST was longer for patients with KRAS mutations, supporting the notion that the presence of a KRAS mutation is a dominant early effect, supporting its role as a driver oncogen. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581113 Fri, 12 Aug 2011 04:00:00 +0100 5581113 http://www.medworm.com/index.php?rid=5581118&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003837%2Fabstract%3Frss%3Dyes Abstract: Identification of new markers for malignant pleural mesothelioma (MPM) is a challenging clinical need. Here, we propose a quantitative proteomics primary screen of the cell surface exposed MPM N-glycoproteins, which provides the basis for the development of new protein-based diagnostic assays. Using the antibody-independent mass-spectrometry based cell surface capturing (CSC) technology, we specifically investigated the N-glycosylated surfaceome of MPM towards the identification of protein-marker candidates discriminatory between MPM and lung adenocarcinoma (ADCA). Relative quantitative CSC analysis of MPM cell line ZL55 in comparison with ADCA cell line Calu-3 revealed a bird's eye view of their respective surfaceomes. In a secondary screen of fifteen MPM and six ADCA, we used h... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581118 Thu, 11 Aug 2011 04:00:00 +0100 5581118 http://www.medworm.com/index.php?rid=5581122&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003862%2Fabstract%3Frss%3Dyes Conclusion: The EI combination is an active regimen in relapsed or refractory SCLC. The trend towards a greater activity of this regimen in patients not pretreated using anthracyclines suggests that class of agents should be tested in SCLC relapsing after the etoposide–platinum standard regimen. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581122 Wed, 10 Aug 2011 04:00:00 +0100 5581122 http://www.medworm.com/index.php?rid=5581116&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003813%2Fabstract%3Frss%3Dyes Abstract: Assessment of exhaled breath condensate (EBC) pH is a promising method for investigating and monitoring airway pathology in a number of lung diseases. In this cross-sectional study we tested whether development of lung cancer is associated with acidification of EBC. EBC was collected in 43 smoking patients with lung cancer (squamous cell carcinoma: 17 patients, adenocarcinoma: 16 patients, and small cell lung cancer: 10 patients) before receiving any anticancer treatment and in 20 healthy smokers without any clinical and radiological evidence of pulmonary tumor. EBC pH was measured by CO2 gas standardization, the most reliable and accurate method at present. EBC pH in patients with pulmonary tumor (6.68±0.02) and in controls (6.63±0.05) was similar (p>0.05). Results were affect... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581116 Wed, 10 Aug 2011 04:00:00 +0100 5581116 http://www.medworm.com/index.php?rid=5581121&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003849%2Fabstract%3Frss%3Dyes Conclusions: The results of our study suggest that hepatic and pulmonary surgical treatment can provide a better prognosis for patients with metachronous hepatic and pulmonary metastases from colorectal carcinoma. We believe that aggressive metastasectomy can be an option for selected patients, even if a patient has been previously treated for hepatic and pulmonary metastases from colorectal carcinoma. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581121 Mon, 08 Aug 2011 04:00:00 +0100 5581121 http://www.medworm.com/index.php?rid=5494712&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003783%2Fabstract%3Frss%3Dyes Abstract: The association of cancer and thrombotic events was first described by Trousseau in 1865. The spectrum of these episodes vary in severity, and these can present during or even prior to the diagnosis of cancer. Multiple factors in patients with lung cancer are associated with a higher risk of thrombosis. Patient-related, cancer-related and treatment-related factors contribute to the development of a thrombotic event. The incidence of thrombotic events in patients with lung cancer is one of the highest among all cancers. Certain particular conditions in lung cancer may be responsible to elevate this risk. Tissue factor (TF) over-expression is considered to be the most important element in cancer-related thrombosis. Several oncogenes and tumor suppressor genes have been implicated w... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494712 Mon, 08 Aug 2011 04:00:00 +0100 5494712 http://www.medworm.com/index.php?rid=5581127&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003771%2Fabstract%3Frss%3Dyes Abstract: Background: The aim of this study was to explore circulating tumor cell (CTC) detection in advanced non-small cell lung cancer (NSCLC). CTCs may not only serve as a prognostic marker in selected tumor types, but may also be useful as pharmacodynamic marker in drug development.Methods: Fourty-six advanced NSCLC patients and fourty-six healthy controls were included in the study and 8.0ml of peripheral blood was obtained from each of the participants. Immunomagnetic bead enrichment for cells expressing epithelial cell adhesion molecule (EpCAM) was performed, followed by multi-marker quantitative real-time PCR of a panel of marker genes: cytokeratin 7 (CK7), cytokeratin 19 (CK19), human epithelial glycoprotein (EGP) and fibronectin 1 (FN1). Using quadratic discriminant analysis (QDA... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581127 Fri, 05 Aug 2011 04:00:00 +0100 5581127 http://www.medworm.com/index.php?rid=5581129&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003795%2Fabstract%3Frss%3Dyes Summary: Background: Evidence-based guidelines recommend chemotherapy for medically fit patients with stages II–IV non-small cell lung cancer (NSCLC). Adherence to chemotherapy guidelines has rarely been studied among large populations, mainly because performance status (PS), a key component in assessing chemotherapy appropriateness, is missing from claims-based datasets. Among a large cohort of patients with known PS, we describe first line chemotherapy use relative to guideline recommendations and identify patient factors associated with guideline concordant use.Patients and methods: Insured patients, ages 50+, with stages II–IV NSCLC between 2000 and 2007 were identified via tumor registry (n=406). Chart abstracted PS, automated medical claims, Census tract information, and travel d... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581129 Thu, 04 Aug 2011 04:00:00 +0100 5581129 http://www.medworm.com/index.php?rid=5581120&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003801%2Fabstract%3Frss%3Dyes Abstract: Aim: To investigate the safety and feasibility of a six-week supervised structured exercise and relaxation training programme on estimated peak oxygen consumption, muscle strength and health related quality of life (HRHRQOL) in patients with inoperable lung cancer, undergoing chemotherapy.Methods: A prospective, single-arm intervention study of supervised, hospital based muscle and cardiovascular group training and individual home-based training. Peak oxygen consumption (VO2peak) was assessed using an incremental exercise test. Muscle strength was measured with one repetition maximum test (1RM). HRQOL was assessed using the Functional Assessment of Cancer Therapy-Lung (FACT-L) scale.Results: Twenty-five patients with non-small cell cancer (NSCLC) stage III–IV and four patients ... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581120 Thu, 04 Aug 2011 04:00:00 +0100 5581120 http://www.medworm.com/index.php?rid=5581119&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100376X%2Fabstract%3Frss%3Dyes Abstract: The effectiveness of lung cancer screening using low-dose chest computed tomography (CT) remains elusive. The present study examined the prognosis of patients with lung cancer detected on CT screening in Japanese men and women. Subjects were 210 patients with primary lung cancer identified on CT screening at two medical facilities in Hitachi, Japan, where a total of 61,914 CT screenings were performed among 25,385 screenees between 1998 and 2006. Prognostic status of these patients was sought by examining medical records at local hospitals, supplemented by vital status information from local government. The 5-year survival rate was estimated according to the characteristics of patients and lung nodule. A total of 203 (97%) patients underwent surgery. During a 5.7-year mean follow... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581119 Wed, 03 Aug 2011 04:00:00 +0100 5581119 http://www.medworm.com/index.php?rid=5087331&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004132%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5087331 Tue, 02 Aug 2011 20:45:52 +0100 5087331 http://www.medworm.com/index.php?rid=5087330&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211004119%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5087330 Tue, 02 Aug 2011 20:45:52 +0100 5087330 http://www.medworm.com/index.php?rid=5581123&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003436%2Fabstract%3Frss%3Dyes Conclusions: Our findings verify angioinvasion and mTOR expression as new biomarkers for poor outcome in patients with early stage NSCLC. mTOR expressing patients may benefit from novel therapies targeting the mTOR survival pathway. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581123 Mon, 01 Aug 2011 04:00:00 +0100 5581123 http://www.medworm.com/index.php?rid=5581115&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003746%2Fabstract%3Frss%3Dyes Conclusions: Culture of A549 or CL1-5 lung cancer cells with MSCs increased sphere formation, drug resistance, and overexpression of pluripotency markers through activation of the IL-6/JAK2/STAT3 pathway. MSCs enhanced the capability of A549 and CL1-5 lung cancer cells to form tumors in immunodeficient mice. Blockade of the IL-6/JAK2/STAT3 pathway attenuated the capability of A549 and CL1-5 cells to form tumors. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581115 Fri, 29 Jul 2011 04:00:00 +0100 5581115 http://www.medworm.com/index.php?rid=5581112&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003734%2Fabstract%3Frss%3Dyes This study confirmed increased mortality from lung cancer and all cancers in asbestos workers, and the cancer mortality was associated with exposure level. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581112 Thu, 28 Jul 2011 04:00:00 +0100 5581112 http://www.medworm.com/index.php?rid=5581125&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003424%2Fabstract%3Frss%3Dyes Abstract: Background: Recent studies have shown that human copper transporter 1 (hCtr1), the major copper influx transporter, is involved in the transport of platinum-based antitumor agents. We investigated the predictive and prognostic values of hCtr1, and copper efflux transporters ATP7A and ATP7B, in patients with locally advanced non-small cell lung cancer (NSCLC) receiving first-line platinum-based chemotherapy.Methods: From 2004 to 2009, we identified 54 consecutive stage III NSCLC patients who underwent first-line platinum-based doublet chemotherapy. Immunohistochemical studies of hCtr1, ATP7A and ATP7B on the paraffin-embedded pre-treatment tumor samples were performed and correlated with chemotherapy response and survival.Results: Overexpression of hCtr1, ATP7A and ATP7B were obse... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581125 Tue, 26 Jul 2011 04:00:00 +0100 5581125 http://www.medworm.com/index.php?rid=5494721&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003333%2Fabstract%3Frss%3Dyes Abstract: It was recently described that high FDG-uptake areas pre-radiotherapy largely correspond with residual metabolic-active areas post-radiotherapy. Here, an independent prospective validation of these results was performed using an overlap-fraction (OF) calculation of various FDG-uptake based thresholds. Data from twelve patients treated at Radboud University Nijmegen Medical Center with lung cancer were analyzed. All patients underwent two FDG-PET-CT scans, one pre-radiotherapy (pre-RT) and one approximately three months after treatment (post-RT). Of the twelve analyzed patients, eight patients showed residual FDG uptake on the post-RT scan and were included for analysis. One of these patients had a residue that was not clearly distinguishable from the surrounding tissue due to FDG... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494721 Fri, 22 Jul 2011 04:00:00 +0100 5494721 http://www.medworm.com/index.php?rid=5581126&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003412%2Fabstract%3Frss%3Dyes Conclusion: High levels of MMP-7 in tumor cells and high levels of MMP-9 in tumor associated stroma were independent positive prognostic factors in NSCLC patients. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581126 Mon, 18 Jul 2011 04:00:00 +0100 5581126 http://www.medworm.com/index.php?rid=5581124&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003400%2Fabstract%3Frss%3Dyes In this study, we retrospectively examined the impact of preoperative peripheral neutrophil and lymphocyte counts on survival, and investigated the relationships of these factors to clinicopathological factors in node-negative NSCLC. A total 237 patients were evaluated. When the cut-off value of neutrophil count was 4500mm−3 with a maximum log-rank statistical value, overall 5-year survival rates were 79.7% for the low-neutrophil-count group and 69.5% for the high-neutrophil-count group (P=0.04). When the cut-off value of lymphocyte count was 1900mm−3 with a maximum log-rank statistical value, overall survival rates were 67.9% for the low-lymphocyte group and 87.7% for the high-lymphocyte group (P (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581124 Mon, 18 Jul 2011 04:00:00 +0100 5581124 http://www.medworm.com/index.php?rid=5581114&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003382%2Fabstract%3Frss%3Dyes We examined the anti-proliferative effect of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), an orally active Hsp90 inhibitor, on the growth of NSCLC cell lines in vitro and in vivo. In MTS assay, the IC50 values of 17-DMAG for 13 EGFR-mutant cell lines including eight EGFR-TKI resistant cell lines ranged from 0.04 to 0.16μM while those for seven EGFR-wild type cell lines ranged from 1.6 to 27.4μM. Western blot analysis revealed that phospho-EGFR, phospho-Akt, phospho-MAPK, cdk4, and cyclin D1 were more readily depleted by 17-DMAG treatment in EGFR-mutant cell lines than in EGFR-wild type cell lines. Cleaved PARP expression confirmed apoptosis in response to 17-DMAG treatment in EGFR-mutant cell lines but not in EGFR-wild type cell lines. In mice xenograft models, 17-DMAG ... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581114 Mon, 18 Jul 2011 04:00:00 +0100 5581114 http://www.medworm.com/index.php?rid=5208112&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003394%2Fabstract%3Frss%3Dyes We describe here 2 cases of primary non-small cell lung cancers (squamous cell and adenocarcinoma, respectively) colliding with metastatic breast carcinomas (ductal and lobular carcinomas, respectively). Clinico-pathologic features characterizing this challenging diagnosis and the important therapeutic implications are discussed. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5208112 Mon, 18 Jul 2011 04:00:00 +0100 5208112 http://www.medworm.com/index.php?rid=5581128&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003370%2Fabstract%3Frss%3Dyes Abstract: There is a need for new treatment strategies and prognostic markers for the management of malignant mesothelioma (MM). The activity of thalidomide/cisplatin/gemcitabine (arm A) or thalidomide alone (arm B) was investigated in two parallel phase II studies in patients with advanced MM, using 6 month progression free survival (PFS) as the principal end-point. The predictive role of pre-treatment and 8 week follow-up serum C-reactive protein (CRP), interlukin-6 (IL-6), interlukin-6 soluble receptor (sIL-6R), mesothelin (SMRP) and vascular endothelial growth factor (VEGF) was also assessed. The proportion of patients with stable disease for >6 months was similar in both studies (arm A 35%, arm B 29%) and toxicity was mainly grade I/II. In univariate analyses only pre-treatment VEGF a... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5581128 Fri, 15 Jul 2011 04:00:00 +0100 5581128 http://www.medworm.com/index.php?rid=5494720&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003278%2Fabstract%3Frss%3Dyes Abstract: Background: Anaplastic lymphoma kinase (ALK) fusion gene-positive lung cancer accounts for 4–5% of non-small cell lung carcinoma. A clinical trial of the specific inhibitor of ALK fusion-type tyrosine kinase is currently under way.Methods: ALK fusion gene products were analyzed immunohistochemically with the materials obtained by surgery or by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). The echinoderm microtubule-associated protein-like 4(EML4)-ALK or kinesin family member 5B (KIF5B)-ALK translocation was confirmed by the reverse transcription polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH). After eligibility criteria were met and informed consent was obtained, 3 patients were enrolled for the Pfizer Study of Cr... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494720 Fri, 15 Jul 2011 04:00:00 +0100 5494720 http://www.medworm.com/index.php?rid=5494716&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003308%2Fabstract%3Frss%3Dyes Abstract: Most non-small cell lung cancer (NSCLC) patients responding to gefitinib harbor activating mutations in the epidermal growth factor receptor (EGFR). However, the responsive cases eventually develop the resistance to gefitinib. Besides, K-ras mutations were identified as the primary resistance to gefitinib. We investigated whether Marsdenia tenacissima extract (MTE, trade name: Xiao-Ai-Ping injection) combined with gefitinib could overcome the resistance of NSCLC cells to gefitinib. NSCLC cell lines with different sensitivities to gefitinib were studied. Cell growth and apoptosis were evaluated by MTT assay and flow cytometry, respectively. The EGFR-related signaling molecule phosphorylation was assessed by Western blotting. We found that MTE inhibited cell growth in gefitinib-sen... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494716 Fri, 15 Jul 2011 04:00:00 +0100 5494716 http://www.medworm.com/index.php?rid=5009632&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003679%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5009632 Sat, 09 Jul 2011 16:22:38 +0100 5009632 http://www.medworm.com/index.php?rid=5009631&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003655%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5009631 Sat, 09 Jul 2011 16:22:38 +0100 5009631 http://www.medworm.com/index.php?rid=5494728&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100328X%2Fabstract%3Frss%3Dyes Conclusion: Co-expression gene set with ASCL1, rather than single NE gene expression, successfully identifies an NE subtype of lung adenocarcinoma with poor prognosis. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494728 Fri, 08 Jul 2011 04:00:00 +0100 5494728 http://www.medworm.com/index.php?rid=5494724&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003345%2Fabstract%3Frss%3Dyes Abstract: MET, a receptor tyrosine kinase for hepatocyte growth factor, is associated with tumor progression and acquired resistance to epidermal growth factor tyrosine kinase inhibitors (EGFR-TKI). Therefore, MET gene alterations could be both prognostic and predictive. Fluorescence in situ hybridization (FISH) is one method for assessing gene alteration, but the frequency of positive cases varies due to a lack of standardized criteria. We evaluated MET gene copy number in lung adenocarcinoma and its association with clinicopathological characteristics. FISH was applied to evaluate high MET gene copy number and true amplification in 138 lung adenocarcinoma patients using two criteria: the Cappuzzo scoring system and PathVysion. MET positive cases according to the Cappuzzo scoring system e... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494724 Wed, 06 Jul 2011 04:00:00 +0100 5494724 http://www.medworm.com/index.php?rid=5494717&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003291%2Fabstract%3Frss%3Dyes In conclusion, mast cell/anti-histamine targeted therapies should carefully consider this dual effect. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494717 Wed, 06 Jul 2011 04:00:00 +0100 5494717 http://www.medworm.com/index.php?rid=5314050&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211001620%2Fabstract%3Frss%3Dyes Conclusions: These results provide clinical evidence to support the notion that BRMS1 is a NSCLC metastasis suppressor gene. Measuring methylation status of BRMS1 promotor is a useful marker for identifying NSCLC patients with worse disease-free survival. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314050 Tue, 05 Jul 2011 04:00:00 +0100 5314050 http://www.medworm.com/index.php?rid=5494722&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003321%2Fabstract%3Frss%3Dyes Conclusion: This study shows that SBRT is an effective and safe local treatment option for patients with lung metastases. Definitive results are strictly correlated to clinical selection of patients. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494722 Mon, 04 Jul 2011 04:00:00 +0100 5494722 http://www.medworm.com/index.php?rid=5494725&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100331X%2Fabstract%3Frss%3Dyes Abstract: Expression of the transcription factor FOXP3 characterizes regulatory T cells (Tregs) that engage in the maintenance of immunological self-tolerance and immune homeostasis. Intra-tumoral accumulation of Tregs is associated with unfavorable prognosis in several kinds of cancers. Recently, expression of FOXP3 and its association with prognosis have also been shown in some cancer cells in clinical studies. For non-small cell lung cancer (NSCLC), however, prognostic significance of tumor FOXP3 expression and its relationship with Tregs remain unknown. FOXP3 expression in cancer cells and tumor-infiltrating lymphocytes was examined by immunohistochemical staining of surgical specimens from 87 patients with NSCLC. Prognostic values of the tumor-infiltrating Treg count and tumor FOXP3 e... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494725 Thu, 30 Jun 2011 04:00:00 +0100 5494725 http://www.medworm.com/index.php?rid=5087352&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003138%2Fabstract%3Frss%3Dyes Abstract: We herein report a case of signet ring cell adenocarcinoma of the lung with an EML4–ALK fusion gene mimicking mucinous (colloid) adenocarcinoma. A 79-year-old female presented with a pulmonary tumor located in the right lower lobe measuring 21mm in size. A right lower lobectomy was performed. The postoperative pathological examination revealed signet ring cell carcinoma with abundant mucin pools, and a multiplex RT-PCR analysis revealed the variant 2 inversion of the EML4–ALK gene. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5087352 Wed, 29 Jun 2011 23:00:00 +0100 5087352 http://www.medworm.com/index.php?rid=5494729&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003266%2Fabstract%3Frss%3Dyes Abstract: Lung cancer survivors exhibit poor functional capacity, physical functioning, and quality of life (QoL). Here, we report the feasibility and preliminary efficacy of a progressive resistance exercise training (PRET) intervention in post-treatment lung cancer survivors. Seventeen post-treatment lung cancer survivors (10 female), with a mean age of 67 (range 50–85), mean BMI of 25, and diagnosed with non-small cell lung cancer (94%) were recruited in Edmonton, Canada between August 2009 and August 2010 to undergo PRET. The primary outcomes focused on feasibility including eligibility and recruitment rate, loss to follow-up, measurement completion, exercise adherence, and program evaluation. Secondary outcomes addressed preliminary efficacy and included changes in muscular strength... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494729 Wed, 29 Jun 2011 04:00:00 +0100 5494729 http://www.medworm.com/index.php?rid=5208091&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003187%2Fabstract%3Frss%3Dyes Abstract: Similar to the adenoma–carcinoma sequence of colorectal cancer, lung adenocarcinoma is thought to follow a linear multistep progression, in which a precursor lesion progresses to adenocarcinoma in situ, which is followed by invasive adenocarcinoma. However, lung adenocarcinoma can no longer be considered as a single type of tumor but rather a group of distinct subsets of tumors that arise from different molecular pathways. Consistent with this concept, recent findings revealed that this linear progression might not occur in all lung adenocarcinomas. First, according to the molecular classification based on expression profiling, lung cancer can be divided into at least two subsets; precancerous and in situ lesions share characteristics of molecular expression and clinical featur... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5208091 Mon, 27 Jun 2011 04:00:00 +0100 5208091 http://www.medworm.com/index.php?rid=5314026&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003254%2Fabstract%3Frss%3Dyes Abstract: Despite the fact that non-small-cell lung cancer (NSCLC) is very common in the older population, these patients are frequently underrepresented in clinical trials evaluating new anti-cancer agents, and thus it is difficult to reach evidence-based recommendations for this special population.The purpose of the present paper is to present the currently available evidence regarding treatment of early-stages of NSCLC in older patients.Although, age is still considered as a negative factor influencing treatment decisions and curative cancer-directed surgery is often omitted in the older population several studies support that surgical resection is feasible in the older patient and that age per se is not a contraindication for various surgical procedures. Pneumonectomy is associated wit... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314026 Wed, 22 Jun 2011 04:00:00 +0100 5314026 http://www.medworm.com/index.php?rid=5494727&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003242%2Fabstract%3Frss%3Dyes Abstract: High expression of KIAA0101 (p15PAF/OEATC-1) which contains a proliferating cell nuclear antigen (PCNA)-binding motif, a key factor in DNA repair and/or apoptosis and cell cycle regulation, has been observed in a variety of human malignancies. The aim of this study was to observe the expression of KIAA0101 in human non-small-cell lung cancer (NSCLC), explore its clinicopathological significance and evaluate KIAA0101 expression as a potential prognostic marker. KIAA0101 transcript was found to be overexpressed in the great majority of lung cancers by semi-quantitative RT-PCR. A total of 357 NSCLCs were analyzed immunohistochemically on tissue microarrays. High-level KIAA0101 expression was observed in 33.9% (121 of 357 cases), and correlated with male gender (P (Source: Lung Cance... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494727 Mon, 20 Jun 2011 04:00:00 +0100 5494727 http://www.medworm.com/index.php?rid=5494723&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003199%2Fabstract%3Frss%3Dyes Conclusion: Both gefitinib and erlotinib showed effective activity and tolerable toxicity profiles as second-line treatment for the selected population of NSCLC. We may consider conducting a phase III trial to directly compare the efficacy and toxicity between gefitinib and erlotinib in an enriched patient population. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494723 Mon, 20 Jun 2011 04:00:00 +0100 5494723 http://www.medworm.com/index.php?rid=5494719&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003163%2Fabstract%3Frss%3Dyes We examined human ASH1 (hASH1) expression across a comprehensive panel of human lung cancer cell lines, primary human lung tumors and normal fetal and post-natal lungs. While hASH1 was a cardinal feature of NE carcinomas, a subgroup of non-NE lung cancers also exhibited expression of this factor. Twenty lung cancer cell lines out of 33 were positive for hASH1 mRNA by reverse transcription PCR, including 6/6 small cell carcinomas (SCLC), 5/5 carcinoids, 6/7 non-SCLC with NE features, and 3/14 other non-SCLC. Among human primary tumors, 2/2 SCLC, 5/5 pulmonary carcinoids, and 10/41 non-SCLC (only 4 of which had NE features) were positive for hASH1 by immunohistochemistry and RNA–RNA in situ hybridization. In normal human fetal lung, the expression of hASH1 and the neural marker synaptophys... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494719 Mon, 20 Jun 2011 04:00:00 +0100 5494719 http://www.medworm.com/index.php?rid=5494718&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003175%2Fabstract%3Frss%3Dyes Conclusions: Here, we demonstrate that cell lines represent a useful in vitro system for studying basic mechanisms in lung cancer, but cover only distinct molecular characteristics of the original tumor. Moreover, we present three novel, comprehensively characterized SCC cell lines. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494718 Mon, 20 Jun 2011 04:00:00 +0100 5494718 http://www.medworm.com/index.php?rid=5494715&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003126%2Fabstract%3Frss%3Dyes Summary: Bronchioloalveolar carcinoma (BAC) pattern is often seen at the margin of invasive adenocarcinomas. We investigated EGFR signaling abnormalities involved in the progression of adenocarcinoma. Fifty tumors were obtained from patients who underwent surgery for lung adenocarcinoma seen as dense areas in ground glass opacity on computed tomography. Six, 18, and 26 tumors (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494715 Mon, 20 Jun 2011 04:00:00 +0100 5494715 http://www.medworm.com/index.php?rid=5087353&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003151%2Fabstract%3Frss%3Dyes We examined epidermal growth factor receptor (EGFR) mutations in exhaled breath condensate (EBC). The DNA extracted from his EBC showed a deletion mutation in exon 19. Subsequently, the del E746-A750 mutation in exon 19 in a transbronchial tissue specimen was confirmed. Although he underwent whole-brain irradiation against multiple brain metastases, he had paralysis of the left side of the body and his performance status was 3. The patient was treated with gefitinib. He had marked tumor regression and no symptoms. Although only a small percentage of heavy smokers with squamous cell carcinoma harbor EGFR mutations, they probably benefit from EGFR-tyrosine kinase inhibitors. EGFR mutation status in the patients having such clinical features might be examined. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5087353 Sun, 19 Jun 2011 23:00:00 +0100 5087353 http://www.medworm.com/index.php?rid=5400345&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002716%2Fabstract%3Frss%3Dyes The objective response rate was 27.4% (95% CI: 18.2, 38.2). The most frequently reported all-causality adverse events of any grade during sunitinib maintenance therapy were fatigue/asthenia (55%), diarrhea (36%), and nausea (32%). These data suggest that maintenance therapy may have value in NSCLC, although the primary endpoint of the study was not met. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400345 Thu, 16 Jun 2011 04:00:00 +0100 5400345 http://www.medworm.com/index.php?rid=5400340&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002704%2Fabstract%3Frss%3Dyes Conclusions: In selected patients, definitive dose CRT followed by major lung resection results in promising DFS and OS. The use of advanced radiotherapy techniques (4DCT and IGRT) appears to result in promising pathologic response rates. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400340 Thu, 16 Jun 2011 04:00:00 +0100 5400340 http://www.medworm.com/index.php?rid=5494726&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003205%2Fabstract%3Frss%3Dyes Conclusion: Present data indicates that ERCC1 118 C/T or T/T might provide a better prognostic predictive marker of NSCLC patients treated with platinum-based chemotherapy, mainly in elderly subgroup, male, squamous carcinoma, smoker and those treated with non-GP/GC regimen. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494726 Wed, 15 Jun 2011 04:00:00 +0100 5494726 http://www.medworm.com/index.php?rid=5494714&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100314X%2Fabstract%3Frss%3Dyes Abstract: Many epidemiological studies show the benefit of fruits and vegetables on reducing risk of lung cancer, the leading cause of cancer death in the United States. Previously, we demonstrated that cigarette smoke exposure (SM)-induced lung lesions in ferrets were prevented by a combination of low dose of β-carotene, α-tocopherol (AT), and ascorbic acid (AA). However, the role of a combination of AT and AA alone in the protective effect on lung carcinogenesis remains to be examined. In the present study, we investigated whether the combined AT (equivalent to ∼100mg/day in the human) and AA (equivalent to ∼210mg/day) supplementation prevents against SM (equivalent to 1.5 packs of cigarettes/day) induced lung squamous metaplasia in ferrets. Ferrets were treated for 6 weeks in the ... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5494714 Mon, 13 Jun 2011 04:00:00 +0100 5494714 http://www.medworm.com/index.php?rid=5400348&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002819%2Fabstract%3Frss%3Dyes Conclusion: Cisplatin and irinotecan combination chemotherapy appears to be acceptable for advanced thymic carcinoma as first-line chemotherapy with respect to efficacy, toxicity, and usage in the clinical setting. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400348 Mon, 13 Jun 2011 04:00:00 +0100 5400348 http://www.medworm.com/index.php?rid=5400341&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002777%2Fabstract%3Frss%3Dyes Abstract: Radiation pneumonitis is an important cause of morbidity after concurrent thoracic chemoradiotherapy (CCRT). However, asymptomatic changes in lung density on computed tomography (CT)-scans occur more commonly, and correspond to regions of inflammatory changes. Characterization of dose- and time-related changes in radiological lung density (RLD) may facilitate improved radiation planning, and allow for a more objective measure for assessing damage. We studied changes in RLD following CCRT with cisplatin–etoposide, using deformable registration to co-register follow-up scans. All CT-scans performed for up to 24 months post-treatment were evaluated in 25 patients treated with CCRT for stage III non-small-cell lung cancer. A total of 104 scans (median of 3 per patient) were co-regi... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400341 Mon, 13 Jun 2011 04:00:00 +0100 5400341 http://www.medworm.com/index.php?rid=5400339&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002789%2Fabstract%3Frss%3Dyes Abstract: Complete surgical resection is the most effective curative treatment for lung cancer. However, many patients with lung cancer also have severe COPD which increases their risk of postoperative complications and their likelihood of being considered “inoperable.” Preoperative pulmonary rehabilitation (PR) has been proposed as an intervention to decrease surgical morbidity but there is no established protocol and no randomized study has been published to date.We tested two preoperative PR interventions in patients undergoing lung cancer resection and with moderate-severe COPD in a randomized single blinded design. Outcomes were length of hospital stay and postoperative complications.The first study tested 4 weeks of guideline-based PR vs. usual care: that study proved to be very ... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400339 Mon, 13 Jun 2011 04:00:00 +0100 5400339 http://www.medworm.com/index.php?rid=5009653&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002820%2Fabstract%3Frss%3Dyes Editor, I read with great interest a recent publication made by Cloran et al. titled “Limitations of dual time point PET in the assessment of lung nodules with low FDG avidity”, the authors concluded that DTP FDG PET may not be of benefit in the assessment of pulmonary nodules with maximum SUV of less than 2.5 on initial imaging. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5009653 Sun, 12 Jun 2011 23:00:00 +0100 5009653 http://www.medworm.com/index.php?rid=5400347&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002790%2Fabstract%3Frss%3Dyes Conclusion: With limited follow up, HT has comparable toxicity to those observed with traditional IMRT. Higher radiation dose and good coverage results in excellent local control. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400347 Fri, 10 Jun 2011 04:00:00 +0100 5400347 http://www.medworm.com/index.php?rid=5400338&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002741%2Fabstract%3Frss%3Dyes Abstract: The efficacy of CT screening for lung cancers is still a controversial issue, although one of the recently publicized large randomized controlled trials of this methodology, the National Lung Screening Trial (NLST), reported a decrease in the lung cancer-specific mortality for heavy smokers. We here performed case-matched comparative analyses, as a retrospective study, of three lung cancer arms detected by CT screen, X-ray screen, and by individual analysis of the clinicopathological features and outcomes in smokers from a symptomatic-prompted group of patients. We also considered the impacts of various potential biases in this cohort. The total study cohort comprised 136 patients in the CT screen group, 263 in the X-ray screen group and 254 in the symptomatic-prompted group. The... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400338 Fri, 10 Jun 2011 04:00:00 +0100 5400338 http://www.medworm.com/index.php?rid=5400337&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100273X%2Fabstract%3Frss%3Dyes In conclusion, CT will improve the survival rate and decrease the rate of advanced cancers in never-smokers via the existing annual screening system. CT-screening is also an independent prognostic improvement factor in never-smokers, and will therefore reduce the risk of lung cancer death. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400337 Fri, 10 Jun 2011 04:00:00 +0100 5400337 http://www.medworm.com/index.php?rid=5208090&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002698%2Fabstract%3Frss%3Dyes Abstract: Lung cancer continues to present an enormous global burden of morbidity and mortality, despite an increasing therapeutic armamentarium of chemotherapy and targeted agents. Recent research efforts have been directed towards identifying predictors of response to treatment, in order to facilitate the selection of patients likely to obtain the greatest benefit from specific therapeutic interventions, with the ultimate goal of providing customized therapy.A strong scientific basis exists for the use of markers to identify patients who are most likely to respond to biological and targeted therapies, based on characteristics such as tumour genotype and histology. Biomarkers have the potential to aid in patient stratification (risk assessment), treatment-response identification (surrogat... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5208090 Thu, 09 Jun 2011 04:00:00 +0100 5208090 http://www.medworm.com/index.php?rid=5400351&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002753%2Fabstract%3Frss%3Dyes Conclusions: This retrospective study shows that uPAR(I–III) and uPAR(I) in serum are independent prognostic factors in patients radically operated for NSCLC. Further prospective studies are needed to validate these markers for clinical use. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400351 Mon, 06 Jun 2011 04:00:00 +0100 5400351 http://www.medworm.com/index.php?rid=5400335&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002686%2Fabstract%3Frss%3Dyes Abstract: Globins are respiratory proteins involved in oxygen metabolism, which is a critical factor in tumor growth and progression. The status of neuroglobin and myoglobin is largely unknown in human malignancies, including lung cancer. The aim of this study was to explore mRNA expression profiles, potential regulatory mechanisms and clinicopathological associations of neuroglobin and myoglobin in non-small cell lung cancer (NSCLC). We screened 208 surgically resected NSCLC specimens and a panel of lung normal and cancer cell lines. The mRNA expression of neuroglobin, myoglobin and hypoxia markers (HIF1α and VEGFa) was measured with qRTPCR, while neuroglobin promoter methylation was assessed with Pyrosequencing. Neuroglobin and myoglobin were upregulated in the tumor samples compared to... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400335 Mon, 06 Jun 2011 04:00:00 +0100 5400335 http://www.medworm.com/index.php?rid=5400329&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002807%2Fabstract%3Frss%3Dyes Abstract: Tumor size at diagnosis (TSD) indirectly reflects tumor growth rate. The relationship between TSD and smoking is poorly understood. The aim of the study was to determine the relationship between smoking and TSD. We reviewed 1712 newly diagnosed and previously untreated non-small cell lung cancer (NSCLC) patients’ electronic medical records and collected tumor characteristics. Demographic and epidemiologic characteristics were derived from questionnaires administered during personal interviews. Univariate and multivariate linear regression models were used to evaluate the relationship between TSD and smoking controlling for demographic and clinical factors. We also investigated the relationship between the rs1051730 SNP in an intron of the CHRNA3 gene (the polymorphism most sign... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400329 Mon, 06 Jun 2011 04:00:00 +0100 5400329 http://www.medworm.com/index.php?rid=5087332&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002650%2Fabstract%3Frss%3Dyes Abstract: Currently, a combination of chemotherapy and radiotherapy is the standard treatment approach for locally advanced non-small cell lung cancer (NSCLC). However, the clinical outcomes are still disappointing, with the 5-year survival rate being only approximately 20%. Further improvement in treatment outcome for patients with locally advanced NSCLC will require the development of more effective combined-modality therapies. Increasing attention has focused on the integration of targeted agents into current therapies. Many preclinical studies in this area have targeted the epidermal growth factor receptor (EGFR) signaling pathway to increase radiosensitivity. The in vitro rationale for targeting EGFR and concurrent ionizing radiation is well established, but to date, rare clinical dat... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5087332 Sun, 05 Jun 2011 23:00:00 +0100 5087332 http://www.medworm.com/index.php?rid=4894812&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003084%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=4894812 Sun, 05 Jun 2011 15:49:56 +0100 4894812 http://www.medworm.com/index.php?rid=4894811&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211003060%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=4894811 Sun, 05 Jun 2011 15:49:56 +0100 4894811 http://www.medworm.com/index.php?rid=5400352&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002765%2Fabstract%3Frss%3Dyes Abstract: Purpose: Lung cancer patients frequently present with weight loss in the context of the cachexia syndrome. Despite its high clinical significance, definite diagnostic criteria of cachexia are lacking. Nutritional screening questionnaires, like the Mini Nutritional Assessment (MNA), have been proposed for the timely diagnosis of the syndrome. The aim of this study was to evaluate the correlation of MNA with laboratory markers of inflammation/cachexia in patients with metastatic lung cancer. The prognostic value of the measured parameters was also examined.Patients and methods: Patients with metastatic lung cancer referred for systemic therapy were eligible. Baseline clinical characteristics were recorded and nutritional status was assessed using MNA. Blood samples were also collec... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400352 Wed, 01 Jun 2011 04:00:00 +0100 5400352 http://www.medworm.com/index.php?rid=5400346&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002728%2Fabstract%3Frss%3Dyes Conclusion: Obatoclax mesylate added to topotecan does not exceed the historic response rate seen with topotecan alone in patients with relapsed SCLC following the first-line platinum-based therapy. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400346 Mon, 30 May 2011 04:00:00 +0100 5400346 http://www.medworm.com/index.php?rid=5400328&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002613%2Fabstract%3Frss%3Dyes Conclusions: Our results confirm that cigarette smoking is by far the most important cause of the current epidemic of lung cancer among French women and that the most important smoking-related variables for varying the risk of lung cancer are the duration, the intensity and the time since cessation. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400328 Mon, 30 May 2011 04:00:00 +0100 5400328 http://www.medworm.com/index.php?rid=5314027&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002674%2Fabstract%3Frss%3Dyes In conclusion, our meta-analysis shows that the p16 expression status is an independent prognostic factor in NSCLC, and this tendency is also found in the subgroups of squamous cell lung cancer and early stage NSCLC (I–II), but not in lung adenocarcinoma. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314027 Mon, 30 May 2011 04:00:00 +0100 5314027 http://www.medworm.com/index.php?rid=5087333&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002625%2Fabstract%3Frss%3Dyes Abstract: The global burden of mesothelioma is expected to increase in the coming decades. As a result the development of more effective therapies with an emphasis on personalized treatments based on validated prognostic and predictive biomarkers is an essential requirement. Progress has been made in the last decade with the development of newer generation anti-folates leading to the current standard of care of pemetrexed and cisplatin in patients with unresectable disease. However, the median overall survival of patients with this combination treatment is only 12 months. There is no consensus regarding second line therapy for patients who have progressed or not responded to pemetrexed based therapies although gemcitabine in combination with a platinum compound or single agent vinorelbine ... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5087333 Sun, 29 May 2011 23:00:00 +0100 5087333 http://www.medworm.com/index.php?rid=5400355&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002649%2Fabstract%3Frss%3Dyes Abstract: The majority of non-small-cell lung cancer (NSCLC) patients present with locally advanced (35%) or metastatic disease (40%); in this setting, it is of the utmost importance to balance efficacy with toxicity. However, with platinum combinations, survival has reached a “plateau”, with median overall survival times of a mere 10–12 months, making it mandatory to search for new strategies and to identify more effective treatment. Molecular characteristics can be more informative than clinical features in predicting clinical benefit, and the identification of molecular markers can help define subgroups of patients who are likely to respond to different treatments, thus avoiding unnecessary toxicities and costs and providing the maximum benefit to each patient. Here we review rese... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400355 Fri, 27 May 2011 04:00:00 +0100 5400355 http://www.medworm.com/index.php?rid=5400331&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002637%2Fabstract%3Frss%3Dyes Conclusion: The anti-VEGF antibody inhibits adhesions between pleural layers. Despite being an experimental study in animals with normal pleura, the results call attention to a likely lack of success in pleurodesis when VEGF blockers are used. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400331 Fri, 27 May 2011 04:00:00 +0100 5400331 http://www.medworm.com/index.php?rid=5009652&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002662%2Fabstract%3Frss%3Dyes Abstract: Small cell lung cancer is commonly regarded as an old age related disease. Although the brain is a common site of metastasis for this type of lung cancer, the first manifestation is rarely shown from the metastasis site. In this paper, we report a rare case of 19-year-old female patient with small cell lung cancer whose initial presentation was a solitary brain metastasis. The patient was admitted to our hospital for the recurrence of brain tumor, and the histological diagnosis after operation showed small cell lung cancer. Three months later, she suffered from dry cough and was diagnosed as small cell lung cancer by trans-bronchial biopsy. Due to the identical cell types and immunohistochemical phenotypes, the brain tumor was retrospectively diagnosed as metastasis of small lung... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5009652 Thu, 26 May 2011 23:00:00 +0100 5009652 http://www.medworm.com/index.php?rid=5400334&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002571%2Fabstract%3Frss%3Dyes Abstract: To clarify the biological differences between small cell lung carcinoma (SCLC) and large cell neuroendocrine carcinoma (LCNEC), we investigated the expression of two bHLH type transcription factors, human achaete-scute homolog 1 (hASH1) and hairy/enhancer of split 1 (HES1), which positively and negatively regulate the neuroendocrine differentiation of respiratory epithelial cells, respectively. Eighty-eight formalin-fixed and paraffin-embedded pulmonary carcinomas (32 SCLC, 32 LCNEC, 14 adenocarcinomas, and 10 squamous cell carcinomas) and 14 SCLC and 1 LCNEC derived cell lines were used. hASH1 and HES1 mRNA were detected using a highly sensitive in situ hybridization method with digoxigenin-labeled cRNA probes and biotinylated tyramide. The staining results were scored from 0 to... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400334 Wed, 25 May 2011 04:00:00 +0100 5400334 http://www.medworm.com/index.php?rid=5314031&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002546%2Fabstract%3Frss%3Dyes Conclusions: Short-term culture in serum free medium is an effective way to isolate TAM in NSCLC. The results of this study also demonstrated that those up-regulated genes in TAMs contributed to suitable microenvironments for lung cancer invasion and metastasis. These findings may be useful in developing novel therapeutic strategies to prevent lung cancer progression. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314031 Wed, 25 May 2011 04:00:00 +0100 5314031 http://www.medworm.com/index.php?rid=5400354&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002558%2Fabstract%3Frss%3Dyes Abstract: Objective of this indirect economic comparison was to estimate and compare management costs of grade 3/4 adverse events (AEs) reported for first-line erlotinib or pemetrexed maintenance therapy in patients with advanced non-small cell lung cancer (NSCLC). The economic analysis was performed for Germany, France, Italy and Spain.Types and incidences of reported grade 3/4 AEs observed with erlotinib or pemetrexed maintenance therapy were retrieved from two recently published placebo-controlled trials. Country-specific estimates on standard treatment algorithms and incremental medical resource utilization associated with each of the reported grade 3/4 AEs have been obtained from clinical oncologists practicing in the four countries and co-authoring this article. The resource use item... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400354 Wed, 18 May 2011 04:00:00 +0100 5400354 http://www.medworm.com/index.php?rid=5400343&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100256X%2Fabstract%3Frss%3Dyes Abstract: Lung cancer is the most common cancer in the world today, in terms of both incidence and mortality. Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancers, and the majority of people diagnosed with NSCLC have locally advanced or metastatic disease. Treatment algorithms have rapidly changed in the last 10 years because of the introduction of new chemotherapeutic and targeted agents in clinical practice. SUN is a 1-year longitudinal observational multicenter study that has consecutively enrolled patients affected by stage IIIB or IV NSCLC with the aim to describe the pattern of care and evolving approaches in the treatment of advanced NSCLC. 987 consecutive NSCLC patients were enrolled between January 2007 and March 2008 at the 74 participating centers throug... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400343 Wed, 18 May 2011 04:00:00 +0100 5400343 http://www.medworm.com/index.php?rid=5400332&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002200%2Fabstract%3Frss%3Dyes Abstract: Adenosquamous carcinoma (ADSQ) is uncommon in non-small cell lung cancer (NSCLC). The frequency rate of ADSQ was 9.7% of 6990 primary lung cancers resected in our department. Many researches have analyzed genetic and molecular alterations in adenocarcinoma (AD) and squamous cell carcinoma (SQ), but few molecular studies have been conducted on heterogeneous ADSQ. The current study was to investigate gene mutations of epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) and their correlation with clinical variables in Chinese patients with ADSQ. Histologic features were reviewed, and immunohistochemical (IHC) and molecular (EGFR and KRAS) studies were done in 55 Chinese patients with ADSQ. Microscopically, all the tumors demonstrated dual differenti... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400332 Wed, 18 May 2011 04:00:00 +0100 5400332 http://www.medworm.com/index.php?rid=4894829&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002182%2Fabstract%3Frss%3Dyes We report the case of an 85 years old male patient diagnosed of pleural epithelioid hemangioendothelioma, taking advantage to review exhaustively literature and therapy for the disease. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=4894829 Tue, 17 May 2011 23:00:00 +0100 4894829 http://www.medworm.com/index.php?rid=5400353&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002170%2Fabstract%3Frss%3Dyes Abstract: Prolongation of progression-free survival and overall survival have been reported with consolidation therapy after first-line chemotherapy in non-small cell lung cancer, but only a few pharmacoeconomic analyses have been performed. We performed a pharmacoeconomic analysis to assess the cost-effectiveness of consolidation therapy with pemetrexed compared with non-consolidation therapy. We developed a Markov model to evaluate the incremental cost-effectiveness ratio (ICER) of consolidation therapy with pemetrexed compared with non-consolidation therapy based on previous reports. We analyzed all histology groups together, and individually analyzed non-squamous cell carcinoma, in which pemetrexed has been shown to be more effective, and squamous cell carcinoma, in which pemetrexed ha... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400353 Mon, 16 May 2011 04:00:00 +0100 5400353 http://www.medworm.com/index.php?rid=5400342&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002224%2Fabstract%3Frss%3Dyes Conclusions: Continuous administration of EGFR-TKI following radiotherapy after PD in isolated CNS metastasis appears to be a valid treatment option. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400342 Mon, 16 May 2011 04:00:00 +0100 5400342 http://www.medworm.com/index.php?rid=5314043&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211001681%2Fabstract%3Frss%3Dyes Conclusion: This study of erlotinib therapy in 2005–2007 confirms, in the general NSCLC patient population, the results of pivotal trials. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314043 Mon, 16 May 2011 04:00:00 +0100 5314043 http://www.medworm.com/index.php?rid=5400344&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002236%2Fabstract%3Frss%3Dyes Abstract: Background: Gefitinib is an oral tyrosine kinase inhibitor against the epidermal growth factor receptor (EGFR). It has been shown to be active in patients with advanced non-small cell lung cancer (NSCLC) whose tumors contain EGFR mutations.Methods: We performed a meta-analysis of four randomized studies that compared gefitinib with chemotherapy in the first-line treatment of patients with advanced NSCLC: IPASS, North-East Japan, West Japan and first-SIGNAL studies. Patients were selected either on the basis of known EGFR mutations or based on clinicopathologic criteria – non-smokers with adenocarcinomas – associated with increased likelihood of EGFR mutations.Results: Nearly 2000 patients were enrolled on these four trials. Median ages ranged from 57 to 64years. Seventy-six p... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400344 Thu, 12 May 2011 04:00:00 +0100 5400344 http://www.medworm.com/index.php?rid=5400350&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002212%2Fabstract%3Frss%3Dyes In this study, HLA-F expression in 83 primary non-small-cell lung cancer (NSCLC) lesions and corresponding adjacent normal tissues were analyzed with immunohistochemistry. Relevance of HLA-F expression with clinical parameters and patient survival was evaluated. Data revealed that HLA-F expression was observed in 24.1% (20/83) of the NSCLC primary lesions but not in adjacent normal lung tissues. HLA-F expression was not significantly relative to clinicoparameters including patient age, gender, tumor histological type, grade of tumor differentiation and TNM stage. Unexpectedly, patients with HLA-F positive expression had a significantly worse prognosis (p=0.017). The median overall survival for the patients with HLA-F positive was 10.0 months (range: 4.4–18.3 months) and with HLA-F negati... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400350 Wed, 11 May 2011 04:00:00 +0100 5400350 http://www.medworm.com/index.php?rid=5400330&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002194%2Fabstract%3Frss%3Dyes Conclusions: High expression of cyclin D3 confers resistance to erlotinib in vitro and in vivo. Cyclin D3 immunohistochemical staining warrants investigation as a biomarker for predicting erlotinib resistance. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400330 Tue, 10 May 2011 04:00:00 +0100 5400330 http://www.medworm.com/index.php?rid=5400336&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002169%2Fabstract%3Frss%3Dyes Conclusions: The expression of TS, OPRT and DPD was closely related to the grade of malignancy in thymic epithelial tumors. A positive expression of TS, DPD and OPRT might be an important factor in predicting the effectiveness of 5-FU based chemotherapy in this disease. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400336 Mon, 09 May 2011 04:00:00 +0100 5400336 http://www.medworm.com/index.php?rid=4771775&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002509%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=4771775 Mon, 02 May 2011 14:51:36 +0100 4771775 http://www.medworm.com/index.php?rid=4771774&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002480%2Fabstract%3Frss%3Dyes (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=4771774 Mon, 02 May 2011 14:51:36 +0100 4771774 http://www.medworm.com/index.php?rid=5400333&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100211X%2Fabstract%3Frss%3Dyes Abstract: Although progastrin-releasing peptide (proGRP) is used as a serum tumor marker for small cell lung cancer (SCLC), high serum pro-GRP concentrations are observed in some non-small-cell lung cancers (NSCLCs). The characteristics of these NSCLCs are not well known. To determine the clinicopathological features of NSCLC in patients with elevated serum proGRP concentrations, serum proGRP values were assessed in 654 advanced lung cancer patients, and positive (>46pg/mL) NSCLC specimens were subjected to cytological and histopathological reevaluation. Serum proGRP concentrations were positive in 34 of 421 NSCLC patients (8.1%) and 186 of 233 SCLC patients (80%). Histological subtypes of the 34 NSCLC patients at diagnosis were 20 adenocarcinomas, 5 squamous cell carcinomas, 4 large cell ... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400333 Mon, 02 May 2011 04:00:00 +0100 5400333 http://www.medworm.com/index.php?rid=5314051&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100208X%2Fabstract%3Frss%3Dyes Abstract: Background: The aim of this study was to assess the predictive value of tumor expression of nine genes on clinical outcome in patients with advanced NSCLC receiving platinum–gemcitabine chemotherapy.Methods: Quantitative PCR or immunohistochemistry were used to analyze the expression of β-tubuline IIA (TUBB2A), β-tubuline III (TUBB3), BRCA1, ERCC1, Abraxas (ABRX) and RAP80 in mRNA isolated from paraffin-embedded tumor biopsies of 45 NSCLC patients treated as part of a larger observational trial. All patients received first-line platinum–gemcitabine chemotherapy for stage IIIB or IV NSCLC.Results: Median progression-free survival (PFS) was 7 months, overall survival (OS) 12 months. A partial treatment response was found in 14 patients (33%). Patients with low ERCC1 or ABRX e... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314051 Mon, 02 May 2011 04:00:00 +0100 5314051 http://www.medworm.com/index.php?rid=5314044&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211001711%2Fabstract%3Frss%3Dyes Conclusions: Higher efficacy of erlotinib after gefitinib failure can be achieved with proper patient selection criteria, including good PS, benefit from prior gefitinib therapy, and insertion of cytotoxic chemotherapies between gefitinib and erlotinib therapies. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314044 Mon, 02 May 2011 04:00:00 +0100 5314044 http://www.medworm.com/index.php?rid=5314033&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002066%2Fabstract%3Frss%3Dyes Abstract: The goal of this study was to evaluate the usefulness of electrospray ionization-mass spectrometry (ESI-MS) technology to distinguish sera of early-stage lung cancer patients from control individuals. ESI-MS m/z (mass divided by charge) data were generated from sera of 43 non-small cell lung cancer patients (pathological stages I and II) and 21 control individuals. Identifications of m/z peak area significances between cancer and control ESI-MS sera spectra were performed using t-tests. A “leave one out” cross validation procedure, which mimics blinded sera analysis and corrects for “over-fitting” of data, yielded discriminatory cancer versus control distribution p value and ROC curve area value of (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314033 Mon, 02 May 2011 04:00:00 +0100 5314033 http://www.medworm.com/index.php?rid=5400349&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002121%2Fabstract%3Frss%3Dyes Abstract: Purpose: N2 non-small-cell lung cancer (NSCLC) is a heterogeneous disease with an extremely wide range of 5-year survival rates. A composite method of sub-classification for N2 is likely to provide a more accurate method to more finely differentiate prognosis of N2 disease.Methods: A total of 720 pN2 (T1-4N2M0) NSCLC cases were enrolled in our retrospective analysis of the proposed composite method. Survival rates were respectively calculated according to the N2 stratification methods: singly by “nodal stations”, “nodal zones”, or “nodal chains”, or by combination of all three. Statistical analysis was carried out by Kaplan–Meier and Cox regression models.Results: A total of 10,199 lymph nodes (8059 mediastinal; 2140 hilar and intra-lobar) were removed. By nodal sta... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5400349 Fri, 29 Apr 2011 04:00:00 +0100 5400349 http://www.medworm.com/index.php?rid=5314054&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211001644%2Fabstract%3Frss%3Dyes Conclusion: Expression of Klotho was predictive of a favorable outcome following resection in limited-disease SCLC patients, and the Klotho expression status may serve as a new biomarker for the need of additional therapies to be developed in the future. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314054 Fri, 29 Apr 2011 04:00:00 +0100 5314054 http://www.medworm.com/index.php?rid=5314046&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211001498%2Fabstract%3Frss%3Dyes Conclusion: Lung transplantation is associated with a relatively high prevalence of bronchogenic cancer, particularly in the native lung, in patients with primary chronic obstructive pulmonary disease/idiopathic pulmonary fibrosis, and a history of smoking. The cancer is usually diagnosed at an advanced stage with poor outcome. Efforts to improve screening are recommended, as aggressive management and treatment may be beneficial for earlier stage disease. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314046 Fri, 29 Apr 2011 04:00:00 +0100 5314046 http://www.medworm.com/index.php?rid=5314042&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002078%2Fabstract%3Frss%3Dyes Conclusions: High dose induction chemotherapy with carboplatin and paclitaxel and stem cell support in patients with stage IIIA–IIIB NSCLC produced response rates and survival similar to standard therapy. Excessive toxicity (and cost) suggests that this approach does not merit further investigation. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314042 Fri, 29 Apr 2011 04:00:00 +0100 5314042 http://www.medworm.com/index.php?rid=5314032&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211001632%2Fabstract%3Frss%3Dyes Conclusions: These data demonstrate that sorafenib and gemcitabine synergistically interact against NSCLC cells, through suppression of Akt, c-Kit and ERK phosphorylation, induction of apoptosis and modulation of dCK, RRM1, RRM2 and RKIP gene expression. The association between traditional cytotoxic agents with new target-specific agents, such as sorafenib, is a challenge for both clinical and preclinical future investigations in lung cancer treatments. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314032 Fri, 29 Apr 2011 04:00:00 +0100 5314032 http://www.medworm.com/index.php?rid=5009633&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002054%2Fabstract%3Frss%3Dyes Abstract: Accurate radiological staging of small-cell lung cancer (SCLC) is of paramount importance in selection of individual patients with limited stage disease for potentially curative treatment while avoiding toxic treatment in those with distant metastatic disease. [18F] flurodeoxy-d-glucose (FDG) positron emission tomography (PET) is an attractive tool for this purpose but there is limited evidence to support its use in the routine staging of SCLC. Whether therapeutic decisions based on FDG-PET imaging should be made remains uncertain. There is only preliminary evidence for use of FDG-PET as a prognostic biomarker, in the assessment of response to treatment and delineation of disease in conformal radiation planning. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5009633 Wed, 27 Apr 2011 23:00:00 +0100 5009633 http://www.medworm.com/index.php?rid=5314028&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211001656%2Fabstract%3Frss%3Dyes Abstract: Chemokines play an important role in the pathogenesis of non-small cell lung cancer (NSCLC). Although the deregulations of chemokines have been reported to be associated with the development and progression of many human cancers including lung cancer, polymorphisms of chemokine genes have not been examined with the survival of NSCLC.We systematically investigated associations of 23 common potentially functional SNPs in the key chemokine genes (CCL2, CCL5, CCL8, CCL20, CCL22, CXCL1, CXCL6, CXCL9 and CXCL12) with the survival of NSCLC in a case cohort of 568 NSCLC patients in a Chinese population. The results showed that variant genotypes of CCL2 rs3760396 and CCL8 rs3138035 were associated with a significantly decreased risk of death for NSCLC (dominant model: adjusted HR=0.65, 95... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314028 Mon, 25 Apr 2011 04:00:00 +0100 5314028 http://www.medworm.com/index.php?rid=5314041&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100167X%2Fabstract%3Frss%3Dyes Conclusion: Minimally invasive CT-guided interstitial brachytherapy is safe, useful, less complicated and considered as a palliative treatment option for inoperable non-small cell lung cancer. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314041 Fri, 22 Apr 2011 04:00:00 +0100 5314041 http://www.medworm.com/index.php?rid=5314030&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002091%2Fabstract%3Frss%3Dyes Conclusion: Our findings demonstrate significant anti-proliferative, non-toxic effects of indomethacin and IBMX on SCLC cells in vitro. Treated SCLC cells further possess increased neuronal characteristics in vitro, possibly leading to a reduced malignant potential. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314030 Fri, 22 Apr 2011 04:00:00 +0100 5314030 http://www.medworm.com/index.php?rid=5009634&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211002108%2Fabstract%3Frss%3Dyes We present a case of classic biphasic pulmonary blastoma in a 77-year old male and review the literature. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5009634 Thu, 21 Apr 2011 23:00:00 +0100 5009634 http://www.medworm.com/index.php?rid=5314056&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211001723%2Fabstract%3Frss%3Dyes Conclusion: The complexity of the issues involved in the development of symptom distress needs to be recognised by health care professionals in this poor prognosis group of patients. Better patient preparation about symptoms may alleviate some of the symptom distress in lung cancer patients. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314056 Thu, 21 Apr 2011 04:00:00 +0100 5314056 http://www.medworm.com/index.php?rid=5314052&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS016950021100170X%2Fabstract%3Frss%3Dyes Abstract: Estrogen signaling pathways may play a significant role in the pathogenesis of non-small cell lung cancers (NSCLC) as evidenced by the expression of aromatase and estrogen receptors (ERα and ERβ) in many of these tumors. Here we examine whether ERα and ERβ levels in conjunction with aromatase define patient groups with respect to survival outcomes and possible treatment regimens. Immunohistochemistry was performed on a high-density tissue microarray with resulting data and clinical information available for 377 patients. Patients were subdivided by gender, age and tumor histology, and survival data was determined using the Cox proportional hazards model and Kaplan–Meier curves. Neither ERα nor ERβ alone was predictor of survival in NSCLC. However, when coupled with aromat... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314052 Thu, 21 Apr 2011 04:00:00 +0100 5314052 http://www.medworm.com/index.php?rid=5314037&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211001735%2Fabstract%3Frss%3Dyes Conclusion: Diagnosis of satellite nodules associated with early stage NSCLC is common. We developed a predictive score to estimate the probability of malignancy which may be a precious aid in the management of pulmonary nodules associated to a NSCLC. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314037 Thu, 21 Apr 2011 04:00:00 +0100 5314037 http://www.medworm.com/index.php?rid=5009635&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500210005441%2Fabstract%3Frss%3Dyes Conclusions: Our results suggest that greater telomere length may be associated with higher risk of lung cancer among male smokers. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5009635 Wed, 20 Apr 2011 23:00:00 +0100 5009635 http://www.medworm.com/index.php?rid=4771776&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211001589%2Fabstract%3Frss%3Dyes Abstract: Although stage IV non small cell lung cancer (NSCLC) remains an incurable disease and drug resistance ultimately develops, important steps forward have been made within the last few years. The number of new active agents is rapidly increasing and the area of personalized medicine has definitively arrived. Treatment choices are starting to be made upon tumour characteristics, and more effective and better tolerated agents are now available. In the molecular era we are facing many new challenges: The availability of sufficient tissue, which is often not easily accessible in a tumour arising from an internal organ, sensitivity and specificity of biomarker testing, heterogeneity of marker profiles between primary tumour and metastases or even within a single tumour mass, application ... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=4771776 Sun, 17 Apr 2011 23:00:00 +0100 4771776 http://www.medworm.com/index.php?rid=5314055&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211001693%2Fabstract%3Frss%3Dyes Conclusion: Our results indicate that infiltrating CD4+, CD8+, and CD20+ lymphocytes in cancer stroma may cooperate to suppress cancer progression and their presence together appear to be prognostic factor in thymic carcinoma. (Source: Lung Cancer) Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314055 Thu, 14 Apr 2011 04:00:00 +0100 5314055 http://www.medworm.com/index.php?rid=5314035&cid=s_36841_6_f&fid=36841&url=http%3A%2F%2Fwww.lungcancerjournal.info%2Farticle%2FPIIS0169500211001516%2Fabstract%3Frss%3Dyes Abstract: Aim: The aim of the study was to evaluate endobronchial ultrasound (EBUS) for peripheral lung lesions and to find the most cost effective combination of sampling techniques.Materials: 264 patients with lesions suspicious of malignancy were recruited in Bergen and Aalesund, Norway from 2005 to 2008.Methods: The study was a prospective randomised cohort study. EBUS was performed with a 1.7mm rotating probe. X-ray fluoroscopy was used in both arms. The different sampling techniques were evaluated in a cost-effectiveness analysis.Results: The detection rate for cancer was 36% in the EBUS group, 44% in the non-EBUS group (ns). Lesions below 3cm and lesions assumed difficult to reach had significant lower detection rates in the EBUS group. Lesions visualised by EBUS had a higher detect... Lung Cancer journals http://www.medworm.com/rss/comments.php?id=5314035 Wed, 13 Apr 2011 04:00:00 +0100 5314035