MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Magyar Onkologia' source. Sat, 30 Jan 2010 13:49:16 +0100 http://www.medworm.com/index.php?rid=3179516&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071304%26dopt%3DAbstract Authors: Tímár J, Kásler M, Heringh A, Soós M, Mathiász D, Romány A, Józsa A, Szilák L, Forrai T, Patthy L, Kovács G In the 3rd year of the program 8 new molecular diagnostic services have been introduced to clinic in the management of breast-, lung-, colorectal cancers as well as in GIST and melanoma. Two patents have been filed for innovative modulation of mito/motogenic signaling pathways in cancer cells. In preclinical models of human cancer a functional imaging technique was developed to detect vascular eff ects of erythropoietin. Using a genomic approach, the sequential changes in human melanoma during systemic dissemination were determined revealing several novel potential prognostic factors and some interesting novel targets for ther... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3179516 Tue, 01 Dec 2009 00:00:00 +0100 3179516 http://www.medworm.com/index.php?rid=3179515&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071305%26dopt%3DAbstract Authors: Kulka J, Tokés AM, Tóth AI, Szász AM, Farkas A, Borka K, Járay B, Székely E, Istók R, Lotz G, Madaras L, Korompay A, Harsányi L, László Z, Rusz Z, Molnár BA, Molnár IA, Kenessey I, Szentmártoni G, Székely B, Dank M The purpose of the study was to identify breast cancer subtypes by immunohistochemistry likely to respond to neoadjuvant chemotherapy and to analyze the used chemotherapy regimen and the range of response rates. Analysis of a collected database was performed. Ninety-two patients were identified in our files who received neoadjuvant chemotherapy between 1998 and 2009. We used immunohistochemical profiles (ER, PgR, HER2, Ki-67 and p53) of NCB, FNAB and surgical breast specimens to subclassify the tumors.... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3179515 Tue, 01 Dec 2009 00:00:00 +0100 3179515 http://www.medworm.com/index.php?rid=3179514&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071306%26dopt%3DAbstract Authors: Rápolti E, Szigeti A, Farkas R, Bellyei S, Boronkai A, Papp A, Gömöri E, Horváth OP, Mangel L We investigated the response rate and side effects of simultaneous, neoadjuvant radiochemotherapy (RCT) in locally advanced rectal cancer. Between 2005 and 2007, we treated 112 patients in stage II-III rectal carcinoma at the Institute of Oncotherapy, University of Pécs. For staging abdomino-pelvic CT (112) and transrectal US (49) or pelvic MR (10), or PET-CT (1) was performed. Radiation therapy was delivered with 3D CRT-based technique using belly-board with 18 MV photon energy, while patients in prone position. A total dose of 45 Gy (single dose 1.8 Gy) was delivered to the tumor and the pelvic lymph nodes. 5-FU and Ca-folinate was administered concomitantly... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3179514 Tue, 01 Dec 2009 00:00:00 +0100 3179514 http://www.medworm.com/index.php?rid=3179513&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071307%26dopt%3DAbstract We present a summary of currently available RT-PCR and microarray based multigene tests including MammaPrint, Oncotype DX, BLN Assay, Theros Breast Cancer Index SM, MapQuant DX, ARUP Breast Bioclassifier, Celera Metastatic Score, eXagen BCtm, Invasive Gene Signature, Wound Response Indicator and Mammostrat. Two of these (Oncotype DX and MammaPrint) are already incorporated in several diagnostic protocols. However, multiple unsolved issues deteriorate the value of these tests: generally the validation is poor, the gene sets do not confirm each other, the associated costs are high and the necessary bioinformatics is highly complex. PMID: 20071307 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3179513 Tue, 01 Dec 2009 00:00:00 +0100 3179513 http://www.medworm.com/index.php?rid=3179512&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071308%26dopt%3DAbstract Authors: Kopper L, Tímár J There is no doubt that molecular targeted therapy has increasing importance in clinical oncology. Markers related to the molecular targets can help in the prediction of the antitumoral effect as well as in the positive or negative selection of patients. Such a marker is KRAS, since its mutation inhibits the effectiveness of anti-EGFR monoclonal antibodies in the treatment of advanced and/or metastatic colorectal cancer. To identify KRAS mutations different methods and techniques are available. A voluntarily performed study served to control the validity of our methods. As a result the 7 partcipating laboratories approached but not fulfilled (except one) the criteria set by EPS. A joint discussion helped to call the attention to some technical and fi... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3179512 Tue, 01 Dec 2009 00:00:00 +0100 3179512 http://www.medworm.com/index.php?rid=3179511&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071309%26dopt%3DAbstract Authors: Pikó B HER2 is overexpressed in 20-25% of breast cancers and is associated with an aggressive phenotype and poor prognosis. Lapatinib is a dual tyrosine kinase inhibitor selective for inhibition of epidermal growth factor receptor (EGFR1/ErbB1) and HER2/ErbB2. Having more targets, probably its antitumor activity could be more efficient. Preclinical data reveal that lapatinib has activity in trastuzumab-resistant cell lines as well as synergistic activity with trastuzumab. Phase I clinical trials have also shown that lapatinib is well tolerated, with mild diarrhea and skin rush as common toxic effects and low incidence of cardiotoxicity. Lapatinib can cross the blood-brain barrier and might therefore have a role in preventing central-nervous-system progression. In a pivota... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3179511 Tue, 01 Dec 2009 00:00:00 +0100 3179511 http://www.medworm.com/index.php?rid=3179510&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071310%26dopt%3DAbstract Authors: Gyorffy H Gastrointestinal tumors are highly ranked regarding tumoral mortality worldwide. The development and progression of gastrointestinal (GI) diseases go hand in hand with the changes of tight junctions (TJ). Claudins (CLDN) are the main TJ proteins, showing different expression by the different tissues, with the expressed CLDN profile being representative. I. We explored the changes of CLDN expression in Barrett's esophagus and related adenocarcinoma. CLDN2 and -3 expression in Barrett's esophagus was higher than in normal foveolar epithelium. Adenocarcinoma showed higher CLDN2 and -3 expression compared with normal and Barrett's epithelia. The similar CLDN expression profile of Barrett's esophagus and adenocarcinoma supports their sequential development. II. Gastric in... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3179510 Tue, 01 Dec 2009 00:00:00 +0100 3179510 http://www.medworm.com/index.php?rid=3179509&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071311%26dopt%3DAbstract Authors: Szarvas T Bladder cancer is the second most common malignancy affecting the urinary system. Currently, histology is the only tool that determines therapy and patients' prognosis. As the treatment of non-invasive (Ta/T1) and muscle invasive (T2-T4) bladder tumors are completely different, correct staging is important, although it is often hampered by disturbing factors. Molecular methods offer new prospects for early disease detection, confirmation of unclear histological findings and prognostication. Applying molecular biological methods, the present study is searching for answers to current diagnostic and prognostic problems in bladder carcinoma. We analyzed tumor, blood and/or urine samples of 334 bladder cancer patients and 117 control individuals. Genetic alterations were ... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3179509 Tue, 01 Dec 2009 00:00:00 +0100 3179509 http://www.medworm.com/index.php?rid=3179508&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071312%26dopt%3DAbstract Authors: PMID: 20071312 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3179508 Tue, 01 Dec 2009 00:00:00 +0100 3179508 http://www.medworm.com/index.php?rid=3179507&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071313%26dopt%3DAbstract Authors: PMID: 20071313 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3179507 Tue, 01 Dec 2009 00:00:00 +0100 3179507 http://www.medworm.com/index.php?rid=3179506&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071314%26dopt%3DAbstract Authors: PMID: 20071314 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3179506 Tue, 01 Dec 2009 00:00:00 +0100 3179506 http://www.medworm.com/index.php?rid=3179505&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071315%26dopt%3DAbstract Authors: PMID: 20071315 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3179505 Tue, 01 Dec 2009 00:00:00 +0100 3179505 http://www.medworm.com/index.php?rid=3179504&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20071316%26dopt%3DAbstract Authors: PMID: 20071316 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3179504 Tue, 01 Dec 2009 00:00:00 +0100 3179504 http://www.medworm.com/index.php?rid=3172856&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793687%26dopt%3DAbstract Authors: László L, Tamás N Chemotherapy options of metastatic colorectal cancer (mCRC) have been progressed rapidly in the last years. Besides of the standard fluorouracil/folinic acid treatment some new active agents (oxaliplatin and irinotecan) have been introduced, and more recently the "targeted" biologicals (bevacizumab, cetuximab, panitumumab) have demonstrated their high effectiveness. This review summarizes the development of the first line treatment of mCRC. PMID: 19793687 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3172856 Tue, 01 Sep 2009 00:00:00 +0100 3172856 http://www.medworm.com/index.php?rid=3172855&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793688%26dopt%3DAbstract Authors: Csilla P, Csaba W, Réka K, Balázs K, Stipan Z, István P, Pál Z The aim of this publication is to review the requirements necessary for using computed tomography (CT) for radiotherapy treatment planning. The equipments were tested with different CT phantoms. The authors made several measurements for checking the CT number, the quality and the mechanical parameters of CT tables. The CT numbers measured on the equipments of different manufacturers were in quite good agreement with the IAEA requirements. The geometric distortions of CT images are negligible, while the mechanical parameters of CT tables show considerable variety. A quality assurance - quality control protocol is recommended to implement in a safe workflow. PMID: 19793688 [PubMed - indexed fo... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3172855 Tue, 01 Sep 2009 00:00:00 +0100 3172855 http://www.medworm.com/index.php?rid=3172854&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793689%26dopt%3DAbstract In this study, the mRNA expression of 29 invasion-related molecules (18 cell membrane receptors or receptor subunits (EGFRs and integrins) and 11 ECM components: collagens, laminins and fibronectin) was investigated by quantitative reverse transcriptase-polymerase chain reaction. Fresh frozen human tissue samples from glioblastoma (GBM) and intracerebral bronchial adenocarcinoma metastases (five pieces from each) were evaluated. Significant differences were established in six of the 29 molecules (ErbB1, 2, 3, integrins alpha3, 7 and beta1). To confirm our results at the protein level, immunohistochemical analysis of nine molecules was performed. The staining intensity differed definitely in the case of ErbB1, 2 and integrins alpha3 and beta1. Determining the differences in invasion-related... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3172854 Tue, 01 Sep 2009 00:00:00 +0100 3172854 http://www.medworm.com/index.php?rid=3172853&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793690%26dopt%3DAbstract Authors: Miklós F, Klara B, Miklós K The mandible and the fibula are two totally different bones of the human skeleton. The fibula is a long straight bone of the lower leg playing secondary role compared with the tibia. The mandible, or jaw bone, is the only facial bone that moves and has complex spatial structure. The blood supply of the mandible is mainly endosteal, the inferior mandibular artery, which is one of the more important branch of the maxillary artery is responsible for its arterial supply. The fibula shows the uniform pattern of periosteal blood supply receiving many small branches from the peroneal artery, and having only weak endosteal supply. The mandible articulates with the two temporal bone, and the fibula articulates with the tibia at the tibio-fibular sy... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3172853 Tue, 01 Sep 2009 00:00:00 +0100 3172853 http://www.medworm.com/index.php?rid=3172852&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793691%26dopt%3DAbstract Authors: Zsófia K, István B, József L, Vanda P, Sándor M, Zsuzsanna P Despite of its rich vascularization and extensive circulatory communication with neighboring organs, penile metastases are rare. Even more infrequent is a penile metastasis of rectum tumors. Since the first report of rectal carcinoma with metastasis to the penis (Ehbert 1870), approximately 50 cases have been reported, most of them from the USA, the remaining from Western Europe, the Middle East and Japan. The first Hungarian case is reported now of penile metastasis of a rectal carcinoma. The case of a 65-year-old man is presented: isolated penile metastasis discovered 4.5 years after the primary rectal cancer resection. IHC tissue diagnosis and detailed clinical investigations confirmed metastat... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3172852 Tue, 01 Sep 2009 00:00:00 +0100 3172852 http://www.medworm.com/index.php?rid=3172851&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793692%26dopt%3DAbstract Authors: Lilla T Bisphosphonates are used for supportive treatment in bone metastases of malignant diseases. Advance in various therapeutic options, molecular targeted therapies of malignant diseases result in longer survival, and may bring a higher number of patients surviving until development of secondary lesions, e.g. bone metastases. This review summarizes the antitumor activity of the amino-bisphosphonate zoledronate, describing results of in vitro and animal model studies. Zoledronic acid treatment in patients with malignant solid tumors causing bone metastases prolongs their survival. According to the emerging, until now not too large amount of data, zoledronic acid may have a clinically significant and important direct antitumor activity which is resulted by many pathomechanic... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3172851 Tue, 01 Sep 2009 00:00:00 +0100 3172851 http://www.medworm.com/index.php?rid=3172850&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793693%26dopt%3DAbstract Authors: Katalin B Claudins (CLDNs) are essential proteins of tight junctions. Changes in their expression pattern have been demonstrated in a number of tumors. CLDNs-3 and -4 are receptors of the Clostridium perfringens enterotoxin, cytolytic effects of the toxin are well known. The aim of our studies was to compare the different CLDN expression patterns in normal pancreas cells, pancreatic endocrine tumors, adenocarcinomas, mucinous cystic tumors and acinar cell carcinomas. Expressions of CLDN-1, -2, -3, -4 and -7 proteins were examined using immunohistochemical as well as RT-PCR techniques and the following observations were made: 1.) In addition to the well-known CLDN-1 and -4 expression CLDN-2, -3 and -7 proteins were demonstrated in ductal cells, while CLDN-3 and -7 proteins show... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3172850 Tue, 01 Sep 2009 00:00:00 +0100 3172850 http://www.medworm.com/index.php?rid=3172849&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793694%26dopt%3DAbstract Authors: Krisztina B The aim of the research was to detect the acute and long-term ototoxic effect of cisplatin in testicular cancer patients, using OAE (otoacoustic emission), a highly sensitive new objective method, for detecting medication-related hearing loss. Secondary objective was to evaluate the risk factors that contribute to hearing loss. In the study for acute hearing loss ten males with different histological types of testicular germ cell tumor were examined with TOAE (transiently evoked otoacoustic emission), before the 1st and after the 5th day of their 1st cycle of cytostatic therapy. Patients received 100 mg/m 2 cisplatin per cycle (20 mg/m 2 for five days). Ten age-matched healthy volunteers of good hearing and without treatment were also examined with the same method.... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3172849 Tue, 01 Sep 2009 00:00:00 +0100 3172849 http://www.medworm.com/index.php?rid=3172848&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793698%26dopt%3DAbstract Authors: PMID: 19793698 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=3172848 Tue, 01 Sep 2009 00:00:00 +0100 3172848 http://www.medworm.com/index.php?rid=2856399&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793687%26dopt%3DAbstract Authors: Landherr L, Nagykálnai T Chemotherapy options of metastatic colorectal cancer (mCRC) have been progressed rapidly in the last years. Besides of the standard fluorouracil/folinic acid treatment some new active agents (oxaliplatin and irinotecan) have been introduced, and more recently the "targeted" biologicals (bevacizumab, cetuximab, panitumumab) have demonstrated their high effectiveness. This review summarizes the development of the first line treatment of mCRC. PMID: 19793687 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2856399 Mon, 31 Aug 2009 23:00:00 +0100 2856399 http://www.medworm.com/index.php?rid=2856398&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793688%26dopt%3DAbstract Authors: Pesznyák C, Weisz C, Király R, Kiss B, Zelić S, Polgár I, Zaránd P The aim of this publication is to review the requirements necessary for using computed tomography (CT) for radiotherapy treatment planning. The equipments were tested with different CT phantoms. The authors made several measurements for checking the CT number, the quality and the mechanical parameters of CT tables. The CT numbers measured on the equipments of different manufacturers were in quite good agreement with the IAEA requirements. The geometric distortions of CT images are negligible, while the mechanical parameters of CT tables show considerable variety. A quality assurance - quality control protocol is recommended to implement in a safe workflow. PMID: 19793688 [PubMed - ... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2856398 Mon, 31 Aug 2009 23:00:00 +0100 2856398 http://www.medworm.com/index.php?rid=2856397&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793689%26dopt%3DAbstract In this study, the mRNA expression of 29 invasion-related molecules (18 cell membrane receptors or receptor subunits (EGFRs and integrins) and 11 ECM components: collagens, laminins and fibronectin) was investigated by quantitative reverse transcriptase-polymerase chain reaction. Fresh frozen human tissue samples from glioblastoma (GBM) and intracerebral bronchial adenocarcinoma metastases (five pieces from each) were evaluated. Significant differences were established in six of the 29 molecules (ErbB1, 2, 3, integrins alpha3, 7 and beta1). To confirm our results at the protein level, immunohistochemical analysis of nine molecules was performed. The staining intensity differed definitely in the case of ErbB1, 2 and integrins alpha3 and beta1. Determining the differences in invasion-related... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2856397 Mon, 31 Aug 2009 23:00:00 +0100 2856397 http://www.medworm.com/index.php?rid=2856396&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793690%26dopt%3DAbstract Authors: Fülöp M, Branzaniuc K, Kásler M The mandible and the fibula are two totally different bones of the human skeleton. The fibula is a long straight bone of the lower leg playing secondary role compared with the tibia. The mandible, or jaw bone, is the only facial bone that moves and has complex spatial structure. The blood supply of the mandible is mainly endosteal, the inferior mandibular artery, which is one of the more important branch of the maxillary artery is responsible for its arterial supply. The fibula shows the uniform pattern of periosteal blood supply receiving many small branches from the peroneal artery, and having only weak endosteal supply. The mandible articulates with the two temporal bone, and the fibula articulates with the tibia at the tibio-f... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2856396 Mon, 31 Aug 2009 23:00:00 +0100 2856396 http://www.medworm.com/index.php?rid=2856395&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793691%26dopt%3DAbstract Authors: Küronya Z, Bodrogi I, Lövey J, Plótár V, Manninger S, Pápai Z Despite of its rich vascularization and extensive circulatory communication with neighboring organs, penile metastases are rare. Even more infrequent is a penile metastasis of rectum tumors. Since the first report of rectal carcinoma with metastasis to the penis (Ehbert 1870), approximately 50 cases have been reported, most of them from the USA, the remaining from Western Europe, the Middle East and Japan. The first Hungarian case is reported now of penile metastasis of a rectal carcinoma. The case of a 65-year-old man is presented: isolated penile metastasis discovered 4.5 years after the primary rectal cancer resection. IHC tissue diagnosis and detailed clinical investigations confirmed me... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2856395 Mon, 31 Aug 2009 23:00:00 +0100 2856395 http://www.medworm.com/index.php?rid=2856394&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793692%26dopt%3DAbstract Authors: Tamási L Bisphosphonates are used for supportive treatment in bone metastases of malignant diseases. Advance in various therapeutic options, molecular targeted therapies of malignant diseases result in longer survival, and may bring a higher number of patients surviving until development of secondary lesions, e.g. bone metastases. This review summarizes the antitumor activity of the amino-bisphosphonate zoledronate, describing results of in vitro and animal model studies. Zoledronic acid treatment in patients with malignant solid tumors causing bone metastases prolongs their survival. According to the emerging, until now not too large amount of data, zoledronic acid may have a clinically significant and important direct antitumor activity which is resulted by many pathome... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2856394 Mon, 31 Aug 2009 23:00:00 +0100 2856394 http://www.medworm.com/index.php?rid=2856393&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793693%26dopt%3DAbstract Authors: Borka K Claudins (CLDNs) are essential proteins of tight junctions. Changes in their expression pattern have been demonstrated in a number of tumors. CLDNs-3 and -4 are receptors of the Clostridium perfringens enterotoxin, cytolytic effects of the toxin are well known. The aim of our studies was to compare the different CLDN expression patterns in normal pancreas cells, pancreatic endocrine tumors, adenocarcinomas, mucinous cystic tumors and acinar cell carcinomas. Expressions of CLDN-1, -2, -3, -4 and -7 proteins were examined using immunohistochemical as well as RT-PCR techniques and the following observations were made: 1.) In addition to the well-known CLDN-1 and -4 expression CLDN-2, -3 and -7 proteins were demonstrated in ductal cells, while CLDN-3 and -7 proteins showed... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2856393 Mon, 31 Aug 2009 23:00:00 +0100 2856393 http://www.medworm.com/index.php?rid=2856392&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793694%26dopt%3DAbstract Authors: Biró K The aim of the research was to detect the acute and long-term ototoxic effect of cisplatin in testicular cancer patients, using OAE (otoacoustic emission), a highly sensitive new objective method, for detecting medication-related hearing loss. Secondary objective was to evaluate the risk factors that contribute to hearing loss. In the study for acute hearing loss ten males with different histological types of testicular germ cell tumor were examined with TOAE (transiently evoked otoacoustic emission), before the 1st and after the 5th day of their 1st cycle of cytostatic therapy. Patients received 100 mg/m 2 cisplatin per cycle (20 mg/m 2 for five days). Ten age-matched healthy volunteers of good hearing and without treatment were also examined with the same method.... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2856392 Mon, 31 Aug 2009 23:00:00 +0100 2856392 http://www.medworm.com/index.php?rid=2856391&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793695%26dopt%3DAbstract Authors: Mayer A PMID: 19793695 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2856391 Mon, 31 Aug 2009 23:00:00 +0100 2856391 http://www.medworm.com/index.php?rid=2856390&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793696%26dopt%3DAbstract Authors: PMID: 19793696 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2856390 Mon, 31 Aug 2009 23:00:00 +0100 2856390 http://www.medworm.com/index.php?rid=2856389&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793697%26dopt%3DAbstract Authors: PMID: 19793697 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2856389 Mon, 31 Aug 2009 23:00:00 +0100 2856389 http://www.medworm.com/index.php?rid=2856388&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793698%26dopt%3DAbstract Authors: PMID: 19793698 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2856388 Mon, 31 Aug 2009 23:00:00 +0100 2856388 http://www.medworm.com/index.php?rid=2856387&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19793699%26dopt%3DAbstract Authors: PMID: 19793699 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2856387 Mon, 31 Aug 2009 23:00:00 +0100 2856387 http://www.medworm.com/index.php?rid=2769023&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581175%26dopt%3DAbstract Authors: Landherr L, Nagykálnai T Elderly patients will be the largest group of oncology patients in the future. Because of minimal participation of older patients in randomized clinical trials there is a lack of evidence-based data to make correct decisions with regard to chemotherapy and/or targeted therapy in this age group. Elderly patients have similar benefits from systemic therapies as younger counterparts, but many elders have substantial co-morbidities, which may limit the life expectancy and the effectiveness of systemic therapy. Close collaboration between oncologists and geriatrists will help make decisions on the management of elderly patients suffering from cancer. PMID: 19581175 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2769023 Sun, 31 May 2009 23:00:00 +0100 2769023 http://www.medworm.com/index.php?rid=2769022&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581176%26dopt%3DAbstract Authors: Bogner B, Hegedûs G Venous invasion (VI) is one of the most important prognostic factors in colorectal carcinomas (CRC). The interobserver variation of this feature varies between 10% and 89.5%, mainly due to the specimen processing and staining. VI was assessed using haematoxylin and eosin (H+E) alone in 611 cases and with elastic stain (orcein-haematoxylin) in 243 CRCs. The stage, the pattern of invasion and the presence of intramural and extramural VI were determined. VI was identified in 27.45% of the H+E stained sections and in 67.1% using elastic stain counterstained with haematoxylin. The incidence of VI proved stage dependent as it has been noted in 13% of Dukes A, 36% of Dukes B, 80% of Dukes C and in 83% of CRCs with distant metastasis. The pattern of invasion i... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2769022 Sun, 31 May 2009 23:00:00 +0100 2769022 http://www.medworm.com/index.php?rid=2769021&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581178%26dopt%3DAbstract Authors: Vereczkey I, Tóth E, Orosz Z About 15-20% of all ovarian epithelial neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential) and about 5-7% are mucinous type, which are the second most common type behind the serous borderline tumors. The borderline tumor is a serious diagnostic and treatment problem both for the pathologists and for clinicians. These tumors appeared to be intermediate in their histologic and prognostic features between the benign cystadenomas and clearly malignant carcinomas. The borderline tumors occur most commonly in childbearing age, and show an indolent course. Their prognosis is good, but they are resistant to the traditional chemotherapies. To diagnose the intraepithelial carcinoma, to detect the microinv... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2769021 Sun, 31 May 2009 23:00:00 +0100 2769021 http://www.medworm.com/index.php?rid=2769020&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581179%26dopt%3DAbstract Authors: Pikó B In the molecular target treatment strategy of metastatic colorectal cancer patients panitumumab represents a new class of drugs due to its fully human nature, and no need for premedication and loading dose. Panitumumab binds to epidermal growth factor receptor (EGFR) selectively. In registration pivotal studies the analysis of patient subgroups for KRAS status gives strong evidence for the important role of RAS oncogene: median progression-free survival was 16 weeks on panitumumab arm in KRAS wild-type patients (8 weeks in best supportive care), while in KRAS mutant patients panitumumab showed no efficacy, however adverse events were more frequent and severe. According to SmPC, panitumumab is indicated as monotherapy for the treatment of patients with EGFR expressi... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2769020 Sun, 31 May 2009 23:00:00 +0100 2769020 http://www.medworm.com/index.php?rid=2769019&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581180%26dopt%3DAbstract Authors: Zatkóné Puskás G Patients with cancer and bone metastasis usually need to be treated with bisphosphonates to reduce or delay skeletal complications (pathologic fracture, hypercalcemia, surgery or radiotherapy). The nurses can provide important education to patients, support and encourage use of bisphosphonates throughout therapy. Literatures, training, congress reports provide useful information about bisphosphonate therapy, side effects, adverse events etc. However, patients need more information to support them during courses. To optimize the care, nurses can monitor pain scores, changes in mobility, adverse events, creating clearance levels. A useful tool for recording these parameters is a patients-diary. The nurse should fill out the diary at each patients ... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2769019 Sun, 31 May 2009 23:00:00 +0100 2769019 http://www.medworm.com/index.php?rid=2769018&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581181%26dopt%3DAbstract Authors: Végso G The increasing frequency of malignant tumors developing during chronic immunosuppression is an important determinant of the long-term survival of organ transplanted patients. This problem can be solved only if we are aware of the special characteristics concerning our patients. The incidence and frequency of tumors occurring in kidney transplant recipients differ from those of the Hungarian population. The increased tumor risk resulting from chronic renal failure, increasing age of prospective kidney recipients and, in addition, the increasing frequency of tumors diagnosed in the early post-transplantation period emphasize the importance of regular oncological screening of patients on the waiting list. Early diagnosis and treatment of tumors and precancerous condi... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2769018 Sun, 31 May 2009 23:00:00 +0100 2769018 http://www.medworm.com/index.php?rid=2769017&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581182%26dopt%3DAbstract In this study, potential biomarkers were examined that were thought to develop as biologic responses to the known environmental toxicities, therefore, their testing is supposed to help answer the most important questions of clinical oncology: understanding tumor development, early detection of cancer and individually tailored therapy planning based on the biological nature of a particular cancer. Elevated rate of spontaneous chromosome aberrations proved to be a reliable marker of the SCCHN phenotype. However, increased mutagen sensitivity by the bleomycin-test, unlike in the US or in Western Europe, was not suitable to detect the individual cancer risk in this country, because of the high mutagen sensitivity of more than half of the healthy Hungarian population examined. In the light of t... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2769017 Sun, 31 May 2009 23:00:00 +0100 2769017 http://www.medworm.com/index.php?rid=2769016&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581184%26dopt%3DAbstract Authors: Pikó B, PMID: 19581184 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2769016 Sun, 31 May 2009 23:00:00 +0100 2769016 http://www.medworm.com/index.php?rid=2769015&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581185%26dopt%3DAbstract Authors: Pikó B, PMID: 19581185 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2769015 Sun, 31 May 2009 23:00:00 +0100 2769015 http://www.medworm.com/index.php?rid=2769014&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581187%26dopt%3DAbstract Authors: PMID: 19581187 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2769014 Sun, 31 May 2009 23:00:00 +0100 2769014 http://www.medworm.com/index.php?rid=2581258&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581175%26dopt%3DAbstract Authors: Landherr L, Nagykálnai T Elderly patients will be the largest group of oncology patients in the future. Because of minimal participation of older patients in randomized clinical trials there is a lack of evidence-based data to make correct decisions with regard to chemotherapy and/or targeted therapy in this age group. Elderly patients have similar benefits from systemic therapies as younger counterparts, but many elders have substantial co-morbidities, which may limit the life expectancy and the effectiveness of systemic therapy. Close collaboration between oncologists and geriatrists will help make decisions on the management of elderly patients suffering from cancer. PMID: 19581175 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2581258 Sun, 31 May 2009 23:00:00 +0100 2581258 http://www.medworm.com/index.php?rid=2581257&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581176%26dopt%3DAbstract Authors: Bogner B, Hegedus G Venous invasion (VI) is one of the most important prognostic factors in colorectal carcinomas (CRC). The interobserver variation of this feature varies between 10% and 89.5%, mainly due to the specimen processing and staining. VI was assessed using haematoxylin and eosin (H+E) alone in 611 cases and with elastic stain (orcein-haematoxylin) in 243 CRCs. The stage, the pattern of invasion and the presence of intramural and extramural VI were determined. VI was identified in 27.45% of the H+E stained sections and in 67.1% using elastic stain counterstained with haematoxylin. The incidence of VI proved stage dependent as it has been noted in 13% of Dukes A, 36% of Dukes B, 80% of Dukes C and in 83% of CRCs with distant metastasis. The pattern of invasion is str... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2581257 Sun, 31 May 2009 23:00:00 +0100 2581257 http://www.medworm.com/index.php?rid=2581256&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581177%26dopt%3DAbstract Authors: Berhidi A, Szluka P, Vasas L More and more bibliometric indicators emerge beside the impact factor, and a few of them are promising performance indicators. The aim of the study is to show briefly, but clearly the newest bibliometric measure numbers - like the recent enhancements of Journal Citation Report Web, Hirsch-index, Eigenfactor and SCImago Journal & Country Rank algorithms - focusing on the ranking of oncological journals, and to demonstrate the similarities and differences of the results with some examples. There are unified and well-structured web pages behind the newly appeared indicators, and some of the new numbers are presented in the well-known databases (Web of Science, Scopus) as scientific measures. The ranking of the compared oncological journals based o... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2581256 Sun, 31 May 2009 23:00:00 +0100 2581256 http://www.medworm.com/index.php?rid=2581255&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581178%26dopt%3DAbstract Authors: Vereczkey I, Tóth E, Orosz Z About 15-20% of all ovarian epithelial neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential) and about 5-7% are mucinous type, which are the second most common type behind the serous borderline tumors. The borderline tumor is a serious diagnostic and treatment problem both for the pathologists and for clinicians. These tumors appeared to be intermediate in their histologic and prognostic features between the benign cystadenomas and clearly malignant carcinomas. The borderline tumors occur most commonly in childbearing age, and show an indolent course. Their prognosis is good, but they are resistant to the traditional chemotherapies. To diagnose the intraepithelial carcinoma, to detect the microinv... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2581255 Sun, 31 May 2009 23:00:00 +0100 2581255 http://www.medworm.com/index.php?rid=2581254&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581179%26dopt%3DAbstract Authors: Pikó B In the molecular target treatment strategy of metastatic colorectal cancer patients panitumumab represents a new class of drugs due to its fully human nature, and no need for premedication and loading dose. Panitumumab binds to epidermal growth factor receptor (EGFR) selectively. In registration pivotal studies the analysis of patient subgroups for KRAS status gives strong evidence for the important role of RAS oncogene: median progression-free survival was 16 weeks on panitumumab arm in KRAS wild-type patients (8 weeks in best supportive care), while in KRAS mutant patients panitumumab showed no efficacy, however adverse events were more frequent and severe. According to SmPC, panitumumab is indicated as monotherapy for the treatment of patients with EGFR expressi... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2581254 Sun, 31 May 2009 23:00:00 +0100 2581254 http://www.medworm.com/index.php?rid=2581253&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581180%26dopt%3DAbstract Authors: Zatkóné Puskás G Patients with cancer and bone metastasis usually need to be treated with bisphosphonates to reduce or delay skeletal complications (pathologic fracture, hypercalcemia, surgery or radiotherapy). The nurses can provide important education to patients, support and encourage use of bisphosphonates throughout therapy. Literatures, trainings, congress reports provide useful information about bisphosphonate therapy, side effects, adverse events etc. However, patients need more information to support them during courses. To optimize the care, nurses can monitor pain scores, changes in mobility, adverse events, creatinin clearance levels. A useful tool for recording these parameters is a patients-diary. The nurse should fill out the diary at each patient... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2581253 Sun, 31 May 2009 23:00:00 +0100 2581253 http://www.medworm.com/index.php?rid=2581252&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581181%26dopt%3DAbstract Authors: Végso G The increasing frequency of malignant tumors developing during chronic immunosuppression is an important determinant of the long-term survival of organ transplanted patients. This problem can be solved only if we are aware of the special characteristics concerning our patients. The incidence and frequency of tumors occurring in kidney transplant recipients differ from those of the Hungarian population. The increased tumor risk resulting from chronic renal failure, increasing age of prospective kidney recipients and, in addition, the increasing frequency of tumors diagnosed in the early post-transplantation period emphasize the importance of regular oncological screening of patients on the waiting list. Early diagnosis and treatment of tumors and precancerous condi... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2581252 Sun, 31 May 2009 23:00:00 +0100 2581252 http://www.medworm.com/index.php?rid=2581251&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581182%26dopt%3DAbstract In this study, potential biomarkers were examined that were thought to develop as biologic responses to the known environmental toxicities, therefore, their testing is supposed to help answer the most important questions of clinical oncology: understanding tumor development, early detection of cancer and individually tailored therapy planning based on the biological nature of a particular cancer. Elevated rate of spontaneous chromosome aberrations proved to be a reliable marker of the SCCHN phenotype. However, increased mutagen sensitivity by the bleomycin-test, unlike in the US or in Western Europe, was not suitable to detect the individual cancer risk in this country, because of the high mutagen sensitivity of more than half of the healthy Hungarian population examined. In the light of t... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2581251 Sun, 31 May 2009 23:00:00 +0100 2581251 http://www.medworm.com/index.php?rid=2581250&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581183%26dopt%3DAbstract Authors: PMID: 19581183 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2581250 Sun, 31 May 2009 23:00:00 +0100 2581250 http://www.medworm.com/index.php?rid=2581249&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581184%26dopt%3DAbstract Authors: Pikó B PMID: 19581184 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2581249 Sun, 31 May 2009 23:00:00 +0100 2581249 http://www.medworm.com/index.php?rid=2581248&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581185%26dopt%3DAbstract Authors: Pikó B PMID: 19581185 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2581248 Sun, 31 May 2009 23:00:00 +0100 2581248 http://www.medworm.com/index.php?rid=2581247&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581186%26dopt%3DAbstract Authors: PMID: 19581186 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2581247 Sun, 31 May 2009 23:00:00 +0100 2581247 http://www.medworm.com/index.php?rid=2581246&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19581187%26dopt%3DAbstract Authors: PMID: 19581187 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2581246 Sun, 31 May 2009 23:00:00 +0100 2581246 http://www.medworm.com/index.php?rid=2305189&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318320%26dopt%3DAbstract Authors: Tímár J PMID: 19318320 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2305189 Sun, 01 Mar 2009 05:00:00 +0100 2305189 http://www.medworm.com/index.php?rid=2305186&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318321%26dopt%3DAbstract Authors: Fodor J Adjuvant radiotherapy after modified radical mastectomy and breast-conserving surgery for early-stage invasive breast cancer substantially reduces the risk of locoregional failure and is evidence-based. Using traditional clinical and pathological factors, patients can be classified into subgroups by the risk of locoregional recurrence. In the high-risk groups the absolute benefit of irradiation is larger. However, the patients are over-treated in every subgroup. Substantial proportion of the patients remains free of locoregional recurrence even in the absence of irradiation, and some patients develop locoregional recurrence despite postoperative irradiation. Molecular markers may provide sufficient information to allow accurate individual risk assessment to identify pa... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2305186 Sun, 01 Mar 2009 05:00:00 +0100 2305186 http://www.medworm.com/index.php?rid=2305183&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318322%26dopt%3DAbstract Authors: Zsiray M, Markóczy Z, Magyar M, Lengyel Z, Fekésházy A, Borbély K The authors analyzed the results of PET-CT scans made with oncological indications among 408 patients. One hundred and fifty-four PET-CTs were done to characterize pulmonary foci, after which in 59 cases lung surgery was performed. The method's sensitivity in respect to malignancy was 100%, specificity was 56%. Staging of affected lymph nodes resulted in 17 mediastinoscopies and 54 thoracotomies. In the former indications PET-CT-positive lymph nodes always need cytologic/histologic verification. M-staging done with PET-CT was performed in 141 cases, mediastinal restaging of patients having received neoadjuvant chemotherapy was done in 24 cases. The latter indications we consider superfluous b... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2305183 Sun, 01 Mar 2009 05:00:00 +0100 2305183 http://www.medworm.com/index.php?rid=2305180&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318323%26dopt%3DAbstract Authors: Vereczkey I, Tóth E, Orosz Z About 15-20% of all ovarian neoplasms are of borderline type (or atypical proliferative or carcinoma of low malignant potential). They represent a common diagnostic and treatment problem both for the pathologist and for clinicians. The borderline tumors occur most commonly in childbearing age, show an indolent course and have good prognosis but are resistant to the traditional chemotherapies. The serous borderline tumors are the most common types of borderline ovarian tumors and they can cause differential diagnostic problems even for the experienced pathologist. We studied 30 cases which were diagnosed in our institute from 2000 to 2008. Thirteen were typical serous borderline tumors, in 7 cases the pattern was micropapillary, in 2 cases with... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2305180 Sun, 01 Mar 2009 05:00:00 +0100 2305180 http://www.medworm.com/index.php?rid=2305177&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318324%26dopt%3DAbstract Authors: Molnár P, Méhes G The authors review the current literature on the major biological advances in the molecular testing of brain tumors. The incorporation of several new aspects required for proper disease management into the classical pathology service is in the focus of the review. One of the important achievements of the last years in neuro-oncology is the observation that the promoter methylation status of the MGMT (O6-methylguanine DNA methyltransferase) gene determines the treatment efficacy of temozolomide (Temodal) in glioblastomas. This can best be evaluated by methylation-specific PCR (MSP) using tumor tissue obtained for histological evaluation. Further to this, up-regulation of EGFR signaling through gene amplification has been recognized and targeted by an... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2305177 Sun, 01 Mar 2009 05:00:00 +0100 2305177 http://www.medworm.com/index.php?rid=2305175&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318325%26dopt%3DAbstract Authors: Pikó B, Bassam A Even today, nausea and vomiting are two of the most distressing adverse effects associated with tumor therapy. The authors give an overview of the mechanism and the trigger factors (emetogenic potential of the chemotherapies, the patient risk factors, and the used antiemetic drugs) of nausea and vomiting. A short summary will describe the antiemetic drugs focusing on metoclopramid, steroid and the currently widely used setron therapy which is effective only during the acute phase of chemotherapy-induced nausea and vomiting (CINV). In the treatment of CINV the latest improvement was the introduction of the neurokinin (NK1) receptor antagonist class. Currently the only available agent is aprepitant which is indicated to treat CINV in case of highly and mode... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2305175 Sun, 01 Mar 2009 05:00:00 +0100 2305175 http://www.medworm.com/index.php?rid=2305171&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318326%26dopt%3DAbstract Authors: Dobos J According to recent findings that beside cancers traditionally considered as hormone-dependent, several other tumor types show different behavior in the two sexes, indicating the possible role of endocrine factors in the course of these diseases. The possibility that endocrine factors may influence the clinical course of human malignant melanoma is suggested by the higher survival rate in premenopausal vs. postmenopausal women or men of any ages. However, investigations on the sex hormone receptor status of human cutaneous melanomas and experiments attempting to support the epidemiological results yielded conflicting results. In our human melanoma cell lines we failed to detect steroid receptors at protein level, while quantitative PCR demonstrated that their mRNA expr... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2305171 Sun, 01 Mar 2009 05:00:00 +0100 2305171 http://www.medworm.com/index.php?rid=2305168&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318327%26dopt%3DAbstract Authors: Lukits J In the last 20 years the incidence and mortality of head and neck squamous cell carcinomas showed an increasing rate in Hungary. In our work we examined the microenvironment of head and neck cancers localized in different anatomical regions. Clinical evidence shows that the prognosis of hypopharyngeal tumors is poorer than that of head and neck cancers in other anatomical locations. We investigated if tumor size or vascularity correlates with the biological behavior of these tumors. The results showed that the tumor size of laryngeal cancers in T2 stage were significantly larger than that of hypopharyngeal cancers in T4 stage. Regarding the vascularity or VEGF expression we did not find any difference between these two tumor types, suggesting that the more aggressive ... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2305168 Sun, 01 Mar 2009 05:00:00 +0100 2305168 http://www.medworm.com/index.php?rid=2305164&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318328%26dopt%3DAbstract Authors: Kaposi-Novák P Global transcriptome analysis has been successfully applied to characterize various human tumors, including hepatocellular carcinomas. This novel technology can facilitate early discovery as well as prognostic and therapeutic diversification of cancer patients. To enhance access to the genomic information buried in archived pathology samples, we assessed RT-PCR amplification rates in paraffin-embedded tissues preserved in three different fixatives. Reliable amplification could be achieved from all paraffin-embedded specimens, when the amplicon size did not exceed 225 bp. A longer amplicon size resulted in rapid decrease of yield and reproducibility. In addition, formalin provided superior morphology and better reactivity with claudin-4 and -7 immunohistoche... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2305164 Sun, 01 Mar 2009 05:00:00 +0100 2305164 http://www.medworm.com/index.php?rid=2305161&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318329%26dopt%3DAbstract Authors: PMID: 19318329 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2305161 Sun, 01 Mar 2009 05:00:00 +0100 2305161 http://www.medworm.com/index.php?rid=2305157&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318330%26dopt%3DAbstract Authors: Pikó B PMID: 19318330 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2305157 Sun, 01 Mar 2009 05:00:00 +0100 2305157 http://www.medworm.com/index.php?rid=2305153&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318331%26dopt%3DAbstract Authors: Pikó B PMID: 19318331 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2305153 Sun, 01 Mar 2009 05:00:00 +0100 2305153 http://www.medworm.com/index.php?rid=2305151&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19318332%26dopt%3DAbstract Authors: PMID: 19318332 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2305151 Sun, 01 Mar 2009 05:00:00 +0100 2305151 http://www.medworm.com/index.php?rid=2181524&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068461%26dopt%3DAbstract In this study we have not used the TNM-based clinical stage or any other data of the patients contained by HNCR. Using the Gompertz model, the complete recovery of a cancer patient is always possible and the probability of recovery has a reliable estimate based on a short follow-up period only. We compared our results with five-year survival data of Canada, Italy, Norway and Finland and we did not find substantial differences. For both men and women, considering any specific location, the differences in survival among countries are much smaller than the difference between locations. PMID: 19068461 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2181524 Mon, 01 Dec 2008 05:00:00 +0100 2181524 http://www.medworm.com/index.php?rid=2181523&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068462%26dopt%3DAbstract We examined SSTR-2 expression by immunohistochemistry in primary and recurrent medulloblastoma samples of ten children treated with recurrent medulloblastoma at Semmelweis University, Departments of Pediatrics, between 1998 and 2004. All primary and recurrent tumors have been operated at the National Institute of Neurosurgery. We examined the intensity and the percentage of SSTR-2-positive tumor cells in the primary and recurrent tumor samples. All primary tumors were receptor-positive and SSTR-2 was also expressed in all recurrent medulloblastomas. In our samples the percentage of SSTR-2-positive tumor cells was 30-90%. As a positive in vivo control Octreoscan images were available in two cases. In these cases the results of immunohistochemistry and Octreoscan imaging seemed to correlate.... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2181523 Mon, 01 Dec 2008 05:00:00 +0100 2181523 http://www.medworm.com/index.php?rid=2181522&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068464%26dopt%3DAbstract We examined the specificity and sensitivity in the junctional and dermal component separately, with special consideration to features disturbing the evaluation (regression, halo-like inflammation, etc.). We have concluded that the histological diagnosis of melanocytic tumors is based on the detailed examination of traditional HE slides and the immunohistochemical methods only confirm or weaken our opinion. PMID: 19068464 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2181522 Mon, 01 Dec 2008 05:00:00 +0100 2181522 http://www.medworm.com/index.php?rid=2181521&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068465%26dopt%3DAbstract Authors: Hajdu M, Krutsay M, Chanis W In a 52-year-old women suffering in Recklinghausen's disease, operated for acute abdomen, subserous neurinomas and neurofibroma were found on the jejunum and in the mesentery. Gastrointestinal tumors (neurofibroma, GIST, carcinoid etc.) should be considered in patients with Recklinghausen's disease and gastrointestinal symptoms. PMID: 19068465 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2181521 Mon, 01 Dec 2008 05:00:00 +0100 2181521 http://www.medworm.com/index.php?rid=2181520&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068466%26dopt%3DAbstract Authors: Tátrai P Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancers and is the fifth most common malignancy worldwide. HCC typically develops in the cirrhotic liver. Our preliminary results indicated that agrin, a heparan sulfate proteoglycan (HSPG) detected by us for the first time in the liver, accumulates in the basement membranes (BMs) of the cirrhotic liver and HCC. This novel finding prompted us to investigate the role of agrin in the pathogenesis and differential diagnosis of HCC. First, the previously unspecified monoclonal antibody anti-HSPG clone 7E12 was verified as anti-agrin, using mass spectrometry. Our subsequent experiments were carried out on specimens from 131 patients with chronic liver disease and 18 individuals with healthy liver, from 4... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2181520 Mon, 01 Dec 2008 05:00:00 +0100 2181520 http://www.medworm.com/index.php?rid=2181519&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068467%26dopt%3DAbstract Authors: Kiss J We analyzed the relationship among microvessel density (MVD) and tumor infiltrating cells in cutaneous malignant melanoma. We also studied the effect of hyperforin on tumor- and endothelial cell growth in vitro and in vivo. The density of lymphocyte subpopulations, macrophages, dendritic cells and CD34 + microvessels was determined by immunohistochemistry in primary tumor samples from 52 patients with melanoma thicker than 1 mm. The antiproliferative effect of hyperforin was studied on 16 human- and 7 rat cell lines and on human dermal microvascular endothelial cells (HDMEC). Intratumoral MVD did not show significant association with infiltration for any of these cell types. In the case of peritumoral reactive cell densities analyzed in the whole patient population, sig... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2181519 Mon, 01 Dec 2008 05:00:00 +0100 2181519 http://www.medworm.com/index.php?rid=2181518&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068468%26dopt%3DAbstract Authors: Tóth J, Szántó J Chemotherapy-induced vomiting and nausea is the most common adverse event of anticancer therapy. In different guide-lines (MASCC, NCCN, ESMO and ASCO) antiemetic prophylaxis is directed toward the emetogenic potential of the chemotherapy and the type of vomiting and nausea. Chemotherapeutic agents are classified into four emetic risk groups: high, moderate, low, and minimal. Steroids, dexamethasone, metoclopramide, cannabinoids, benzodiazepines, 5-HT3 receptor antagonists (ondansetron, granisetron, tropisetron) and a new group of antiemetics, the neurokinin1 receptor antagonists are used to prevent anticipatory, acute and delayed vomiting and nausea. This paper examines evidence-based recommendations for optimal use of antiemetics. PMID: 190... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2181518 Mon, 01 Dec 2008 05:00:00 +0100 2181518 http://www.medworm.com/index.php?rid=2181517&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068469%26dopt%3DAbstract Authors: Baki M PMID: 19068469 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2181517 Mon, 01 Dec 2008 05:00:00 +0100 2181517 http://www.medworm.com/index.php?rid=2181516&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068470%26dopt%3DAbstract Authors: Magyarosy E PMID: 19068470 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2181516 Mon, 01 Dec 2008 05:00:00 +0100 2181516 http://www.medworm.com/index.php?rid=2032312&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068460%26dopt%3DAbstract Authors: Tímár J PMID: 19068460 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2032312 Mon, 01 Dec 2008 05:00:00 +0100 2032312 http://www.medworm.com/index.php?rid=2032311&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068461%26dopt%3DAbstract In this study we have not used the TNM-based clinical stage or any other data of the patients contained by HNCR. Using the Gompertz model, the complete recovery of a cancer patient is always possible and the probability of recovery has a reliable estimate based on a short follow-up period only. We compared our results with five-year survival data of Canada, Italy, Norway and Finland and we did not find substantial differences. For both men and women, considering any specific location, the differences in survival among countries are much smaller than the difference between locations. PMID: 19068461 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2032311 Mon, 01 Dec 2008 05:00:00 +0100 2032311 http://www.medworm.com/index.php?rid=2032310&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068462%26dopt%3DAbstract We examined SSTR-2 expression by immunohistochemistry in primary and recurrent medulloblastoma samples of ten children treated with recurrent medulloblastoma at Semmelweis University, Departments of Pediatrics, between 1998 and 2004. All primary and recurrent tumors have been operated at the National Institute of Neurosurgery. We examined the intensity and the percentage of SSTR-2-positive tumor cells in the primary and recurrent tumor samples. All primary tumors were receptor-positive and SSTR-2 was also expressed in all recurrent medulloblastomas. In our samples the percentage of SSTR-2-positive tumor cells was 30-90%. As a positive in vivo control Octreoscan images were available in two cases. In these cases the results of immunohistochemistry and Octreoscan imaging seemed to correlate.... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2032310 Mon, 01 Dec 2008 05:00:00 +0100 2032310 http://www.medworm.com/index.php?rid=2032309&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068463%26dopt%3DAbstract Authors: Bence Z, Kovács G, Jakab Z, Csóka M, Müller J The centres of the Hungarian Paediatric Oncology Network annually take care of 250-300 new patients with childhood cancer, every tenth of them suffering from lymphoma. The aim of our work was to analyse the data of the adolescents (14-19 years) with Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL), comparing their survival rates with younger patients under fourteen and with the international data. From January 1990 to December 2004 there were 281 children diagnosed with HL and 230 with NHL. Among the HL patients 107, while among the NHL patients 51 were older than 14 years old. In the group of HL the distribution of patients according to the stage was similar in younger and older patients. In the NHL group 55... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2032309 Mon, 01 Dec 2008 05:00:00 +0100 2032309 http://www.medworm.com/index.php?rid=2032308&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068464%26dopt%3DAbstract We examined the specificity and sensitivity in the junctional and dermal component separately, with special consideration to features disturbing the evaluation (regression, halo-like inflammation, etc.). We have concluded that the histological diagnosis of melanocytic tumors is based on the detailed examination of traditional HE slides and the immunohistochemical methods only confirm or weaken our opinion. PMID: 19068464 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2032308 Mon, 01 Dec 2008 05:00:00 +0100 2032308 http://www.medworm.com/index.php?rid=2032307&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068465%26dopt%3DAbstract Authors: Hajdu M, Krutsay M, Chanis W In a 52-year-old women suffering in Recklinghausen's disease, operated for acute abdomen, subserous neurinomas and neurofibroma were found on the jejunum and in the mesentery. Gastrointestinal tumors (neurofibroma, GIST, carcinoid etc.) should be considered in patients with Recklinghausen's disease and gastrointestinal symptoms. PMID: 19068465 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2032307 Mon, 01 Dec 2008 05:00:00 +0100 2032307 http://www.medworm.com/index.php?rid=2032306&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068466%26dopt%3DAbstract Authors: Tátrai P Hepatocellular carcinoma (HCC) accounts for 90% of primary liver cancers and is the fifth most common malignancy worldwide. HCC typically develops in the cirrhotic liver. Our preliminary results indicated that agrin, a heparan sulfate proteoglycan (HSPG) detected by us for the first time in the liver, accumulates in the basement membranes (BMs) of the cirrhotic liver and HCC. This novel finding prompted us to investigate the role of agrin in the pathogenesis and differential diagnosis of HCC. First, the previously unspecified monoclonal antibody anti-HSPG clone 7E12 was verified as anti-agrin, using mass spectrometry. Our subsequent experiments were carried out on specimens from 131 patients with chronic liver disease and 18 individuals with healthy liver, from 4... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2032306 Mon, 01 Dec 2008 05:00:00 +0100 2032306 http://www.medworm.com/index.php?rid=2032305&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068467%26dopt%3DAbstract Authors: Kiss J We analyzed the relationship among microvessel density (MVD) and tumor infiltrating cells in cutaneous malignant melanoma. We also studied the effect of hyperforin on tumor- and endothelial cell growth in vitro and in vivo. The density of lymphocyte subpopulations, macrophages, dendritic cells and CD34 + microvessels was determined by immunohistochemistry in primary tumor samples from 52 patients with melanoma thicker than 1 mm. The antiproliferative effect of hyperforin was studied on 16 human- and 7 rat cell lines and on human dermal microvascular endothelial cells (HDMEC). Intratumoral MVD did not show significant association with infiltration for any of these cell types. In the case of peritumoral reactive cell densities analyzed in the whole patient population, sig... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2032305 Mon, 01 Dec 2008 05:00:00 +0100 2032305 http://www.medworm.com/index.php?rid=2032304&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068468%26dopt%3DAbstract Authors: Tóth J, Szántó J Chemotherapy-induced vomiting and nausea is the most common adverse event of anticancer therapy. In different guide-lines (MASCC, NCCN, ESMO and ASCO) antiemetic prophylaxis is directed toward the emetogenic potential of the chemotherapy and the type of vomiting and nausea. Chemotherapeutic agents are classified into four emetic risk groups: high, moderate, low, and minimal. Steroids, dexamethasone, metoclopramide, cannabinoids, benzodiazepines, 5-HT3 receptor antagonists (ondansetron, granisetron, tropisetron) and a new group of antiemetics, the neurokinin1 receptor antagonists are used to prevent anticipatory, acute and delayed vomiting and nausea. This paper examines evidence-based recommendations for optimal use of antiemetics. PMID: 190... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2032304 Mon, 01 Dec 2008 05:00:00 +0100 2032304 http://www.medworm.com/index.php?rid=2032303&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068469%26dopt%3DAbstract Authors: Baki M PMID: 19068469 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2032303 Mon, 01 Dec 2008 05:00:00 +0100 2032303 http://www.medworm.com/index.php?rid=2032302&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068470%26dopt%3DAbstract Authors: Magyarosy E PMID: 19068470 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2032302 Mon, 01 Dec 2008 05:00:00 +0100 2032302 http://www.medworm.com/index.php?rid=2032301&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19068471%26dopt%3DAbstract Authors: PMID: 19068471 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=2032301 Mon, 01 Dec 2008 05:00:00 +0100 2032301 http://www.medworm.com/index.php?rid=1870213&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845494%26dopt%3DAbstract Authors: Mayer A PMID: 18845494 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870213 Mon, 01 Sep 2008 04:00:00 +0100 1870213 http://www.medworm.com/index.php?rid=1870212&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845495%26dopt%3DAbstract Authors: Döme B, Magyar M Despite developments in conventional (chemo)radiotherapy and surgery, survival of non-small cell lung cancer (NSCLC) patients remains poor. Treatments with targeted molecular drugs offer novel therapeutic strategies. Bevacizumab, a recombinant anti-vascular endothelial growth factor (VEGF) antibody, is the antiangiogenic drug at the most advanced stage of development in the therapy of NSCLC. However, a number of questions and future challenges relating to the use of bevacizumab in NSCLC remain. Furthermore, novel agents targeting the pre-existing NSCLC vasculature (i.e. vascular disrupting agents, VDAs) or multiple tyrosine kinase inhibitors have emerged as unique drug classes delivering promising results in several preclinical and clinical studies. Herei... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870212 Mon, 01 Sep 2008 04:00:00 +0100 1870212 http://www.medworm.com/index.php?rid=1870211&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845496%26dopt%3DAbstract Authors: Fülöp M, Boér A, Remenár E, Lengyel C, Kásler M In Hungary the number of oral and pharyngeal cancers is alarmingly high. While the mortality rate in 1955 was 282, by 2005 it rose to 1567. However, in the last 1-2 years stagnation can be observed. Nevertheless, even now significant proportions of men and women are involved. Alcohol consumption and smoking are invariably the leading causes, but one cannot disregard the shortcomings of oral cancer screenings, either. Unfortunately, drastic changes in this field are not likely to occur in the near future. Numerous solutions have been developed for the replacement of soft tissue. In our article, we describe and evaluate four of them. When using these techniques, we were often successful in replacing soft ti... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870211 Mon, 01 Sep 2008 04:00:00 +0100 1870211 http://www.medworm.com/index.php?rid=1870210&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845497%26dopt%3DAbstract Authors: Polgár C, Orosz Z, Kahán Z, Gábor G, Jani N, Cserni G, Hadijev J, Kulka J, Sulyok Z, Boross G, Lázár G, László Z, Diczházi C, Udvarhelyi N, Szabó E, Péntek Z, Major T, Fodor J The aim of this work is to report the preliminary results of the Hungarian multicentric randomised DCIS study. Between 2000 and 2007, 278 patients with ductal carcinoma in situ (DCIS) treated by breast-conserving surgery were randomised according to predetermined risk groups. Low/intermediate-risk patients (n=29) were randomised to 50 Gy whole-breast irradiation (WBI) or observation. High-risk cases (n=235) were allocated to receive 50 Gy WBI vs. 50 Gy WBI plus 16 Gy tumour bed boost. Very high-risk patients (patients with involved surgical margins; n=14)... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870210 Mon, 01 Sep 2008 04:00:00 +0100 1870210 http://www.medworm.com/index.php?rid=1870209&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845498%26dopt%3DAbstract Authors: Kásler M, Remenár E, Boér A, Iványi E, Fülöp M Oral cancer incidence in Hungary is strikingly high, even by international standards. In most cases the tumours are to be treated in advanced stage. Hence it follows that we are often forced to remove a part of the mandible, too. We usually use a fibula free flap to reconstruct the bone deficiency. In this paper we report on our clinical experience with fibula free flap. PMID: 18845498 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870209 Mon, 01 Sep 2008 04:00:00 +0100 1870209 http://www.medworm.com/index.php?rid=1870208&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845499%26dopt%3DAbstract Authors: Haltrich I, Csóka M, Kovács G, Fekete G Primary genetic abnormalities of leukemia cells have important prognostic significance in childhood acute leukemia. In the last two years 30 newly diagnosed or recurrent childhood ALL bone marrow samples were analyzed for chromosomal abnormalities with conventional G-banding and interphase-fluorescence in situ hybridization (I-FISH) using probes to detect BCR/ABL fusions, cryptic TEL/AML1 and MLL rearrangements and p16(9p21) tumor suppressor gene deletions. G-banded karyotype analysis found clonal chromosomal aberrations in 50% of cases. With the use of complementary I-FISH techniques, ALL-specific structural and numerical changes could be identified in 70% of the patients. Nine cases (30%) had subtle chromosomal aberrations wi... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870208 Mon, 01 Sep 2008 04:00:00 +0100 1870208 http://www.medworm.com/index.php?rid=1870207&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845500%26dopt%3DAbstract Authors: Mészáros K, Remenár E, Kásler M The aim of treating head and neck cancer is to eliminate the tumor and save functions as much as possible. Despite all efforts the vital (swallowing) and communicative (phonation, articulation) functions can be injured. The treatment of dysphagia is the most important in the rehabilitation, because it can lead to fatal complications: aspiration pneumonia (for example aspiration of saliva), dehydration, malnutrition. According to the localization of the lesion we distinguish oropharyngeal and esophageal dysphagia. The aspiration may be pre-, intra- and postdeglutitory. The aspiration without coughing is called silent aspiration which is mainly seen in neurogenic dysphagia, but can also happen in head and neck cancer patients. ... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870207 Mon, 01 Sep 2008 04:00:00 +0100 1870207 http://www.medworm.com/index.php?rid=1870206&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845501%26dopt%3DAbstract Authors: Gyarmathy L, Varjas G, Major T, Fodor J, Kásler M The first patient in Hungary was treated by cobalt therapy fifty years ago at the National Institute of Oncology with a Gravicert type equipment. On the occasion of this anniversary, the 50-year history of the Hungarian cobalt therapy is reviewed, and its present role is discussed. The first cobalt unit (Gravicert) was designed by László Bozóky seven years after the first cobalt unit installation in the world in Canada. The megavoltage energy of the Co-60 source (average: 1.25 MeV) resulted in more successful treatments of deep-seated tumors compared to the X-ray therapy. In the next two-three decades, until the widespread use of the high-energy linear accelerators, the Co-60 teletherapy meant the modern rad... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870206 Mon, 01 Sep 2008 04:00:00 +0100 1870206 http://www.medworm.com/index.php?rid=1870205&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845502%26dopt%3DAbstract Authors: PMID: 18845502 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870205 Mon, 01 Sep 2008 04:00:00 +0100 1870205 http://www.medworm.com/index.php?rid=1870204&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845503%26dopt%3DAbstract Authors: Avramucz C, Foubert J PMID: 18845503 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870204 Mon, 01 Sep 2008 04:00:00 +0100 1870204 http://www.medworm.com/index.php?rid=1870203&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845504%26dopt%3DAbstract Authors: Lehoczkyné Hanyecz K PMID: 18845504 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870203 Mon, 01 Sep 2008 04:00:00 +0100 1870203 http://www.medworm.com/index.php?rid=1870202&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845505%26dopt%3DAbstract Authors: PMID: 18845505 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870202 Mon, 01 Sep 2008 04:00:00 +0100 1870202 http://www.medworm.com/index.php?rid=1870201&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845506%26dopt%3DAbstract Authors: PMID: 18845506 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870201 Mon, 01 Sep 2008 04:00:00 +0100 1870201 http://www.medworm.com/index.php?rid=1870200&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18845507%26dopt%3DAbstract Authors: Kásler M, Pikó B, Poller I, Szilágyi I PMID: 18845507 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1870200 Mon, 01 Sep 2008 04:00:00 +0100 1870200 http://www.medworm.com/index.php?rid=1645215&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18640889%26dopt%3DAbstract Authors: Nagykálnai T From the big randomized clinical trials there are evidences that adjuvant endocrine therapy for hormone-sensitive early breast cancer in postmenopausal women should include an aromatase inhibitor (AI). Anastrozole or letrozole should be used upfront for 5 years (ATAC and BIG 1-98), the sequential approach of tamoxifen for 2-3 years, followed by anastrozole or exemestane for 2-3 years is a reasonable alternative (ABCSG8, ARNO 95, IES, ITA), and mostly in patients with node-positive disease completing 5 years of tamoxifen should be offered letrozole up to 4-5 years (MA-17). In each of these trials incorporation of an AI resulted in significant improvement in study endpoints. Further results will be needed to establish the optimal beneficial effect, use, duratio... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1645215 Wed, 23 Jul 2008 08:26:49 +0100 1645215 http://www.medworm.com/index.php?rid=1645214&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18640890%26dopt%3DAbstract Authors: Takácsi Nagy Z, Kásler M In the non-surgical treatment of head and neck tumours, the "organ preserving" modalities have become more and more important. At present radiotherapy is the most important means of this kind of treatment. In the radiotherapy of head and neck cancer local dose escalation is an important factor in increasing local tumour control. However, with sole external beam irradiation it is difficult to spare adjacent normal tissues. Interstitial brachytherapy (BT) is ideally suited to deliver a high dose limited to the volume of the primary tumour, thus maximizing tumour control while minimizing complications. Low-dose-rate (LDR) BT, which has been applied for a long time in the treatment of these tumours, is now challenged by high-dose-rate (HDR) and p... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1645214 Wed, 23 Jul 2008 08:26:49 +0100 1645214 http://www.medworm.com/index.php?rid=1645213&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18640891%26dopt%3DAbstract In conclusion, when cytogenetic biomarkers of alcoholism are examined, the subjective character of self-reports at epidemiologic level and immunologic role of lymphocyte subpopulations as genetic confounders must also be taken into consideration. PMID: 18640891 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1645213 Wed, 23 Jul 2008 08:26:49 +0100 1645213 http://www.medworm.com/index.php?rid=1645212&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18640892%26dopt%3DAbstract The objective was to reveal the caracteristics of the disease. In a prospective single-center study in the period between 1984 and 2004, 243 fistulas were diagnosed. Their data were analyzed using multivariant analysis. The mean age of patients with fistula was 56.9 years, the male-to-female ratio was 4.3:1. The average time of the complaints was 5.2 months, while the time of manifestation of the fistula was 7.5 months. Dysphagia was diagnosed in 97.5% of the patients, fever in 36.9%, and cachexia in 59.5%, respectively. The average loss of weight was 10.4 kg and the average size of the tumor was 7.7 cm. Endoscopic intubation was performed in 176 cases. The average survival was 3.4 months. Patients with fistula were divided into two groups, where the caracteristics of the disease were sign... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1645212 Wed, 23 Jul 2008 08:26:49 +0100 1645212 http://www.medworm.com/index.php?rid=1645211&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18640893%26dopt%3DAbstract Authors: Kásler M, Remenár E, Lengyel CG, Boér A In spite of the continued expansion of non-surgical therapeutic modalities surgery still plays an important role in the treatment of head and neck cancer. Parallel with the use of conventional approaches, more sophisticated surgical approaches, like the use of laser in oncologic surgery, appeared with a more favorable outcome. Laser is a precise surgical tool, particularly when coupled to an operating microscope (with a variable spot size micromanipulator), allowing microprecision and hemostatic ability. The benefits of the use of laser are: bloodless operation field, high hit probability, "no touch" technique, ablasticity, support of tissue repair, and the lack of edema and scar formation. Between 1981 and 2008, 7934 surg... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1645211 Wed, 23 Jul 2008 08:26:49 +0100 1645211 http://www.medworm.com/index.php?rid=1645210&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18640894%26dopt%3DAbstract Authors: Tamási L, Müller V, Magyar P Approximately one half of cancer patients experience nausea or vomiting during chemotherapy containing high-dose cisplatin, despite the use of a corticosteroid and 5-hydroxytryptamine(3) (5-HT(3)) receptor antagonists. The addition of aprepitant, a neurokinin 1 receptor antagonist, improves control of emesis by a further 15-20%, and improves late phase symptoms (>24 h after chemotherapy). The cornerstone of standard first line lung cancer chemotherapy is high-dose cisplatin. Our experience with aprepitant in the chemotherapy of 10 lung cancer patients is described, who reported more than one episode of vomiting caused by chemotherapy despite the use of ondansetron previously. Aprepitant prevented acute and late phase oncoming vomiting ... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1645210 Wed, 23 Jul 2008 08:26:49 +0100 1645210 http://www.medworm.com/index.php?rid=1645209&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18640895%26dopt%3DAbstract Authors: Tímár J, Láng I During the carcinogenesis of colorectal cancer in about half of the cases K-RAS, while much less frequently B-RAF mutation occur in early adenomas. While K-RAS mutant tumors are more likely present in male patients, B-RAF mutant tumors develop more frequently in females and are independent of the microsatellite status. Colorectal cancers are characterized by EGFR expression; the gene is not mutated, rarely amplified and increased copy number is due to chromosomal polysomy. This pheno-/genotype of colorectal cancer lent support to the introduction of anti-EGFR antibody therapies. For a while positive EGFR expression status of the tumor was the basis of patient selection for these targeted therapies in colorectal cancer. Monotherapies with the two ... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1645209 Wed, 23 Jul 2008 08:26:49 +0100 1645209 http://www.medworm.com/index.php?rid=1645208&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18640896%26dopt%3DAbstract Authors: Blaskó G The modern pathobiochemical explanation of the old clinical finding, i.e. that the occurrence of the thromboembolic complications in cancer patients is significantly higher, starts to be clarified on the basis of recent knowledge regarding the role of cancer procoagulant, the expressed tissue factor and the changes in the clotting and fibrinolytic systems. Furthermore, the presently used chemotherapeutic agents have activating effects of the coagulation system as well. The details of these phenomena, the frequently used drugs and their pathobiochemical effects are detailed in this publication. Finally, it gives an outlook regarding the new adjuvant, beneficial effects of the direct anticoagulants in malignancies. PMID: 18640896 [PubMed - in process] (Source: ... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1645208 Wed, 23 Jul 2008 08:26:49 +0100 1645208 http://www.medworm.com/index.php?rid=1645207&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18640897%26dopt%3DAbstract Authors: PMID: 18640897 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1645207 Wed, 23 Jul 2008 08:26:49 +0100 1645207 http://www.medworm.com/index.php?rid=1645206&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18640898%26dopt%3DAbstract Authors: Avramucz C, Horváth A, Kocsis J PMID: 18640898 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1645206 Wed, 23 Jul 2008 08:26:49 +0100 1645206 http://www.medworm.com/index.php?rid=1645205&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18640899%26dopt%3DAbstract Authors: Kahán Z PMID: 18640899 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1645205 Wed, 23 Jul 2008 08:26:49 +0100 1645205 http://www.medworm.com/index.php?rid=1645204&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18640900%26dopt%3DAbstract Authors: PMID: 18640900 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1645204 Wed, 23 Jul 2008 08:26:49 +0100 1645204 http://www.medworm.com/index.php?rid=1368309&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403291%26dopt%3DAbstract Authors: Tímár J PMID: 18403291 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368309 Sat, 12 Apr 2008 19:26:44 +0100 1368309 http://www.medworm.com/index.php?rid=1368308&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403292%26dopt%3DAbstract [Prof. Dr. Arpád mayer 65.] Magy Onkol. 2008;52(1):7 Authors: Németh G PMID: 18403292 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368308 Sat, 12 Apr 2008 19:26:44 +0100 1368308 http://www.medworm.com/index.php?rid=1368307&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403293%26dopt%3DAbstract Authors: Kralovánszky J Antiproliferative cytotoxic agents, of which several are still in clinical practice nowadays, could be characterized by low selectivity, narrow therapeutic index, medium or serious side effects and rapid formation of resistance. In the limited efficacy of these drugs several factors are playing a role such as the age, gender and pharmacogenetics of the patients, the morphological and biological feature of the tumor, moreover, pharmacokinetics and pharmacodynamics of the drugs. The question could be justified if there are methods which, by influencing the above parameters, are helpful in enhancing the efficacy and decreasing the toxic side effects of these drugs. Since a long time we have been interested in evaluating methods of preclinical and clinical leve... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368307 Sat, 12 Apr 2008 19:26:44 +0100 1368307 http://www.medworm.com/index.php?rid=1368306&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403294%26dopt%3DAbstract Authors: Kásler M, Ottó S It is well known that cancer incidence and mortality figures are very poor in Hungary. By providing the latest figures the authors analyze the epidemiological background and the risk factors responsible for this situation. Furthermore, based on international recommendations and national specificities, the authors define areas of action to solve this significant health issue. The main conclusion of their analysis is that it is inevitable to improve oncology care by adjusting it to European standards. The decade-old National Cancer Control Program (NCCP) is improved by incorporating legislatory actions, educational issues, research and development priorities. The program now provides the definition of regional centers, recommend improvements of the fun... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368306 Sat, 12 Apr 2008 19:26:44 +0100 1368306 http://www.medworm.com/index.php?rid=1368305&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403295%26dopt%3DAbstract Authors: Francz M The WHO 1994 classification for endometrial hyperplasias is based on the morphologic features of the lesions. This system characterizes the nuclear cytologic morphology as typical or atypical and describes the glandular architectural pattern as simple or complex. The main problem of this classification is the poor reproducibility. Although the predictive value of the atypical category is high, there are many typical hyperplasia cases with cancer progression. Modern molecular data related to endometrial tumorigenesis and precise computerized morphometric analysis have identified the lesion that may be considered as a precursor of endometrioid adenocarcinoma. By definition, this endometrial intraepithelial neoplasia (EIN) is a clonal proliferation of architecturally and... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368305 Sat, 12 Apr 2008 19:26:44 +0100 1368305 http://www.medworm.com/index.php?rid=1368304&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403296%26dopt%3DAbstract Authors: Tamási L, Müller V, Magyar P, Losonczy G Anemia is common among patients with malignant tumors, due to the disease and chemotherapy. Anemia decreases patient's quality of life, and worsens the dose intensity of chemotherapy. The aim of this retrospective data-analysis was to determine the rate of transfusions and the maintenance of chemotherapeutic dose intensity in 9 small cell lung cancer patients receiving beta-erythropoietin, due to anemia observed after the first cycle of chemotherapy. The mean pre-treatment hemoglobin concentration of the patients was 116.67+/-8.17 g/L (mean+/-SD). The mean pre-erythropoietin hemoglobin concentration at baseline was 103.11+/-7.52 g/L. Six cycles of platina-etoposid were used. The post-treatment hemoglobin concentration of patie... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368304 Sat, 12 Apr 2008 19:26:44 +0100 1368304 http://www.medworm.com/index.php?rid=1368303&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403297%26dopt%3DAbstract Authors: Horváth Z, Farkas P, Ganofszky E, Hitre E, Juhos E, Nagy T, Rubovszky G, Szabó E, Láng I Renal function aberrations during bisphosphonate treatment is a well-known fenomenon. In our retrospective study we examined renal functions of 97 breast cancer patients with bone metastasis during their first year of bisphosphonate treatment i.e. (1) frequency of initial renal function alterations; (2) frequency of decreasing renal function during bisphosphonate treatment; (3) the connection between the laboratory findings and the renal function parameters measured at the beginning of bisphosphonate treatment. At the beginning of bisphosphonate treatment we found a surprisingly high rate (26.80%) of decreased creatinine clearence calculated by the Cockcroft-Gault formule. D... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368303 Sat, 12 Apr 2008 19:26:44 +0100 1368303 http://www.medworm.com/index.php?rid=1368302&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403298%26dopt%3DAbstract Authors: Szentpétery F, Atkári B, Jakab F In developed societies colorectal cancer (CRC) is the second most frequent malignant tumor which causes more than 5000 deaths yearly in Hungary. We have attempted to answer the question how to improve the above mentioned data by the long-term follow-up of patients operated upon for rectal cancer at our department. Of the patients operated on for rectal cancer at our department between March 1990 and April 2006, we have conducted regular follow-up of 297 patients according to a protocol developed by us. We have examined the length of time between the rectum operation and the diagnosis and the number of local recurrences, distant metastases, tumor progression in more than one organ as well as second tumors (independent of the rectal can... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368302 Sat, 12 Apr 2008 19:26:44 +0100 1368302 http://www.medworm.com/index.php?rid=1368301&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403299%26dopt%3DAbstract This article is presenting data on the characteristics of HCPs' most endangered by the negative consequences of emotional labor. Our simple choice question survey was conducted at Debrecen University Medical Healthcare Center with the help of 50 oncology HCPs volunteers. Nearly 90% of the HCPs examined change their true feelings in the course of work. It is very difficult to classify the assemblage of those threatened by the negative upshots of the emotional labor. Due to our research we found appalling differences of work motivation that were tightly interconnected with the respondents' emotional labor and their perceived role/emotional expectations. We succeeded in establishing three clusters and defining each cluster's characteristics. Figures suggest that only somewhat more than the ha... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368301 Sat, 12 Apr 2008 19:26:44 +0100 1368301 http://www.medworm.com/index.php?rid=1368300&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403300%26dopt%3DAbstract Authors: Krutsay M A swollen fallopian tube was found in a 34 years old woman operated for acute abdominal pain. During this operation the fallopian tube together with the appendix were removed. The histological examination identified appendicitis and a lipoma of the fallopian tube. PMID: 18403300 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368300 Sat, 12 Apr 2008 19:26:44 +0100 1368300 http://www.medworm.com/index.php?rid=1368299&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403301%26dopt%3DAbstract Authors: Zatkóné Puskás G The treatment of cancer may be associated with various chemotherapy-induced mucocutaneous reactions. One of the mucocutaneous adverse effects of antineoplastic drugs is the toxic local tissue reaction, the extravasation, which occurs in less than 1-2% of cytotoxic infusions. The standard management of vesicant extravasation includes: discontinuing all local infusants, aspiration of any residual drug, elevating the involved limb, local cooling or warm compresses, local anesthesia, antidotes (sodium thiosulfate for alkylating agents, dimethylsulfoxide (DMSO) for anthracyclines and mitomycin, and hyaluronidase for the vinca alkaloids), and finally surgical debridement with plastic surgery reconstruction. Because the anthracyclines are topoisomerase... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368299 Sat, 12 Apr 2008 19:26:44 +0100 1368299 http://www.medworm.com/index.php?rid=1368298&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403302%26dopt%3DAbstract Authors: Udvardy E, Redl P, Márton I The article discusses osteonecrosis of the jaw as a possible side effect of bisphosphonate treatment. It provides practical guidelines for prevention, diagnosis and management of bisphosphonate-associated osteonecrosis according to literature and clinical evidence. Since controlled clinical trials have not been carried out, the recommendations are based on reviews, reports and clinical experience. Osteonecrosis of the jaw (ONJ) is a historical clinical entity, which can potentially develop in cancer patients receiving bisphosphonate therapy. The pathogenesis of ONJ has not been totally revealed yet. A thorough dental/oral surgical examination and counseling is recommended in cases when intravenous bisphosphonate therapy is needed. All required ... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368298 Sat, 12 Apr 2008 19:26:44 +0100 1368298 http://www.medworm.com/index.php?rid=1368297&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403303%26dopt%3DAbstract Authors: Oláh E PMID: 18403303 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368297 Sat, 12 Apr 2008 19:26:44 +0100 1368297 http://www.medworm.com/index.php?rid=1368296&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403304%26dopt%3DAbstract Authors: Landherr L PMID: 18403304 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368296 Sat, 12 Apr 2008 19:26:44 +0100 1368296 http://www.medworm.com/index.php?rid=1368295&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403305%26dopt%3DAbstract Authors: Vincze B PMID: 18403305 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368295 Sat, 12 Apr 2008 19:26:44 +0100 1368295 http://www.medworm.com/index.php?rid=1368294&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403306%26dopt%3DAbstract Authors: Tímár J PMID: 18403306 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368294 Sat, 12 Apr 2008 19:26:44 +0100 1368294 http://www.medworm.com/index.php?rid=1368293&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403307%26dopt%3DAbstract Authors: Avramucz C The Hungarian Cancer Society organized its 27th Congress in Budapest on the occasion of its 50th anniversary. The 27th jubilee celebration congress took part in the spirit of this in the Budapest Congress and World Trade Center between November 8-10. The Oncology Nursing part had its turn on 10 November where within the frames of Oncology Nursing the invited could listen to presentations in 3 different sections: Prevention, Active Clinical Oncology Nursing and Cure of Souls-Rehabilitation. I could also call November 10th a day of historic importance since the Nursing Section had the opportunity for reorganization on its 50th anniversary and could hold its statutory meeting as a member of the Society of the same rank. Dr. Jan Foubert Ph.D., the former president and p... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368293 Sat, 12 Apr 2008 19:26:44 +0100 1368293 http://www.medworm.com/index.php?rid=1368292&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403308%26dopt%3DAbstract Authors: Podmaniczky E PMID: 18403308 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368292 Sat, 12 Apr 2008 19:26:44 +0100 1368292 http://www.medworm.com/index.php?rid=1368291&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403309%26dopt%3DAbstract Authors: PMID: 18403309 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368291 Sat, 12 Apr 2008 19:26:44 +0100 1368291 http://www.medworm.com/index.php?rid=1368290&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403310%26dopt%3DAbstract Authors: PMID: 18403310 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368290 Sat, 12 Apr 2008 19:26:44 +0100 1368290 http://www.medworm.com/index.php?rid=1368289&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403311%26dopt%3DAbstract Authors: PMID: 18403311 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368289 Sat, 12 Apr 2008 19:26:44 +0100 1368289 http://www.medworm.com/index.php?rid=1368288&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18403312%26dopt%3DAbstract Authors: PMID: 18403312 [PubMed - in process] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1368288 Sat, 12 Apr 2008 19:26:44 +0100 1368288 http://www.medworm.com/index.php?rid=1014631&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660864%26dopt%3DAbstract This article overviews the achievements of our Department generated over the last two decades with a focus on cancer (susceptibility) genes. PMID: 17660864 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1014631 Fri, 09 Nov 2007 01:13:27 +0100 1014631 http://www.medworm.com/index.php?rid=1014630&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660865%26dopt%3DAbstract Authors: Csépe P, Bánóczy J, Dombi C, Forrai J, Gyenes M, Döbrossy L Oral cancer has been identified as a significant public health threat. It is reported that about 3,800 new cases of oral cancer are diagnosed in Hungary each year with approximately 1,700 associated deaths. Oral cancer is the 6th most common cancer in men. Most oral cancers are preventable; 75% of oral cancers are related to tobacco use, alcohol use, or use of both substances together. While there is insufficient evidence to support or refute the use of visual examination as a method of screening for oral cancer in the general population, screening in high-risk populations is highly recommended. It was presumed that high-risk behavior including tobacco and alcohol use is one of the characteristics ... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1014630 Fri, 09 Nov 2007 01:13:27 +0100 1014630 http://www.medworm.com/index.php?rid=1014629&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660866%26dopt%3DAbstract In conclusion, it is fair to say that molecular pathology contributes significantly to the development of clinical oncology. PMID: 17660866 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1014629 Fri, 09 Nov 2007 01:13:27 +0100 1014629 http://www.medworm.com/index.php?rid=1014628&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660867%26dopt%3DAbstract Authors: Kralovánszky J, Adleff V, Hitre E, Pap E, Réti A, Komlósi V, Budai B The cytotoxic effect of 5-fluorouracil (5-FU) is mediated by the inhibition of thymidylate synthase (TS), however, at the same time 5-FU is catabolized by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5-FU may therefore depend on the TS and DPD activity and on pharmacogenetic factors influencing these enzymes. Our aims were (1) to determine the distribution of DPD activity, the frequency of DPD deficiency and the DPD (IVS14+1G>A) mutation in the peripheral blood mononuclear cells of colorectal cancer (CRC) patients, and study the relationship between DPD deficiency and toxicity of 5-FU; (2) to investigate the influence of TS polymorphisms and DPD activity on the survival of CRC patients... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1014628 Fri, 09 Nov 2007 01:13:27 +0100 1014628 http://www.medworm.com/index.php?rid=1014627&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660868%26dopt%3DAbstract Authors: Fodor J The aim of the study was to investigate prognosis of patients who develop an isolated local recurrence (ILR) after conservative surgery (CS) for early-stage invasive breast cancer. Between 1983 and 1987, 415 patients with stage I-II breast cancer were treated with CS. Of these patients, 68 developed an ILR. The mean follow-up time after ILR was 167 months. Cox models taking potential prognostic factors into account were used to estimate the risk of death. On univariate analysis, age (< or =40 vs. >40 years) at first treatment, time to ILR (< or =24 vs. >24 months), type of recurrence (true vs. new primary tumor, NP), and extent of recurrence (operable vs. inoperable) were, but initial tumor stage (pT1 vs. pT2), initial lymph node stage (pN-negative vs. -pos... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1014627 Fri, 09 Nov 2007 01:13:27 +0100 1014627 http://www.medworm.com/index.php?rid=1014626&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660869%26dopt%3DAbstract CONCLUSION: Better understanding of molecular mechanisms and carcinogenetic pathways of bladder cancer and combination of old and new drugs with targeted therapy may increase the effectiveness of treatment in bladder cancer. PMID: 17660869 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1014626 Fri, 09 Nov 2007 01:13:27 +0100 1014626 http://www.medworm.com/index.php?rid=1014625&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660870%26dopt%3DAbstract Authors: Bodoky G In our time, molecular targeted therapy plays a key role in the modern therapy of solid tumors. Of these modalities, in colorectal cancer monoclonal antibodies are introduced in routine use. In our article we provide an overview of the mechanism of action, place in treatment and efficacy of bevacizumab, an angiogenic inhibitor. PMID: 17660870 [PubMed - indexed for MEDLINE] (Source: Magyar Onkologia) Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1014625 Fri, 09 Nov 2007 01:13:27 +0100 1014625 http://www.medworm.com/index.php?rid=1014624&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660871%26dopt%3DAbstract Authors: Bodrogi I Sporadic renal cell carcinomas are characterized by EGFR (HER-1) and EGFR-2 (HER-2) expression, however, signal transduction inhibitors of this pathway were clinically ineffective. Clear cell renal cell cancer is hormone-, irradiation- and chemotherapy resistant with moderate sensitivity to immunotherapy. The only clinically effective class of agents in case of this tumor type was proved to be the angiosuppressive agents. In 2005 FDA approved sorafenib for the first line treatment while in 2006 sunitinib for second line treatment in the cytokine resistant medium-risk renal cell carcinoma. This was followed by the European approval of both agents for second line treatment of renal cell cancer. Sunitinib was approved for first line treatment of renal cell cancer in Eur... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1014624 Fri, 09 Nov 2007 01:13:27 +0100 1014624 http://www.medworm.com/index.php?rid=1014623&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17660872%26dopt%3DAbstract Authors: Gyergyay F Epidermal growth factor receptor (EGFR) is highly expressed in head and neck cancer (HNC). Since EGFR has a large extracellular ligand binding as well as an intracellular tyrosine kinase domain, anti-EGFR therapy may involve anti-ligand binding domain antibody- or tyrosine kinase inhibitor therapies. Phase II-III studies confirmed the efficacy of anti-EGFR antibody therapy in case of squamous cell HNC. In combination with irradiation, anti-EGFR antibody therapy improved survival of locally advanced HNC patients. In case of recurrent or metastatic HNC, anti-EGFR antibody therapy in combination with chemotherapy significantly increased remission rate without increasing toxicity. Although studies on EGFR kinase inhibitors in HNC are in early phase, preliminary data are... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=1014623 Fri, 09 Nov 2007 01:13:27 +0100 1014623 http://www.medworm.com/index.php?rid=938399&cid=s_33202_6_f&fid=33202&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D17922058%26dopt%3DAbstract Authors: Moldvay J Lung cancer is the leading cause of cancer death worldwide, and it is responsible for 20-25% of all cancer deaths. In Hungary, more than 4,000 lung cancer patients receive chemotherapy every year, and of them 3,000 suffer from non-small cell lung cancer. Despite the rapid development in antitumor treatment options, the response rates of chemotherapies in non-small cell lung cancer still remain between 15-35%. Recently, EGFR tyrosine kinase inhibitor therapy has been introduced with a response rate of 15% when used in unselected patients. However, this ratio may increase up to 70% when only patients with tumors containing EGFR mutation are treated. Therefore, results of translational research that could help pulmonologists and oncologists to apply tailored therapy in ... Magyar Onkologia journals http://www.medworm.com/rss/comments.php?id=938399 Fri, 05 Oct 2007 04:00:00 +0100 938399