MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Medical Oncology' source. Sun, 21 Mar 2010 13:52:54 +0100 http://www.medworm.com/index.php?rid=3386314&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1523q4v634645825%2F Abstract  Indoleamine 2,3-dioxygenase (IDO), a catabolizing enzyme of tryptophan, is a novel immunosuppressive agent blocking T-cell activation in neoplastic cells, including acute myeloid leukemia (AML) cells. IDO inhibitors as 1-methyl tryptophan (1MT) can abrogate IDO enzymatic activity and may result in an effective immune response. Mononuclear cells (MNCs) were separated from peripheral blood of 25 AML patients and 25 normal adults. IDO expression was detected by RT-PCR and its enzymatic activity by a colorimetric method. MNCs were cultured and the effects of Adriamycin, 1MT and a mixture of both on blast and lymphocyte cell counts after 24 and 72 h were detected. IDO mRNA and activity were detected in 52% of patients and absent in normal subjects. There was a sig... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3386314 Fri, 19 Mar 2010 06:52:34 +0100 3386314 http://www.medworm.com/index.php?rid=3386315&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg4741737138n5337%2F In this study, a low PIC/TAT ratio and poor PS were significant independent negative prognostic factors for survival in patients with advanced NSCLC. The PIC/TAT ratio may become a surrogate marker for treatment with anticoagulants in the future. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-010-9454-yAuthors Katsuhiro Masago, Kyoto University Department of Respiratory Medicine, Graduate School of Medicine 54 Syogoin-Kawaracho, Sakyo-Ku Kyoto 606-8507 JapanShiro Fujita, Institute of Biomedical Research and Innovation Division of Integrated Oncology Kobe JapanTadashi Mio, Kyoto University Department of Respiratory Medicine, Graduate School of Medicine 54 Syogoin-Kawaracho, Sakyo-Ku Kyoto 606-8507 JapanYosuke Togashi, Kyoto University Department of Respirator... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3386315 Fri, 19 Mar 2010 06:52:33 +0100 3386315 http://www.medworm.com/index.php?rid=3386316&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0868425164582775%2F Abstract  The ADAMs is a multi-functional gene family of membrane proteins possessing a disintegrin and metalloprotease domain. They have potential implications for the metastasis of human tumor cells via cell adhesion and protease activities. However, no studies have yet comprehensively examined the expression of ADAMs in gallbladder carcinoma. The aim of this study was to test the hypothesis that ADAM-17 (otherwise known as tumor necrosis factor-α converting enzyme) is involved in the progression of gallbladder carcinoma. Two hundreds samples of gallbladder carcinoma and sixty non-cancerous gallbladder samples were used to measure the expression of total ADAM-17 by enzyme-linked immunosorbent assay, and the precursor and active forms by western blotting analysis. Express... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3386316 Fri, 19 Mar 2010 06:52:32 +0100 3386316 http://www.medworm.com/index.php?rid=3386318&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F767qr426x4n2w73m%2F Abstract  Astrocyte-elevated gene-1 (AEG-1) plays an important role in diverse cancers and its up-regulation is associated with poor survival of patients. However, the status of AEG-1 expression and its significance in gastric cancer are still unclear. In this study, the expression of AEG-1 was studied in different gastric cancer cell lines and gastric cancer tissues. Expression of AEG-1 was significantly higher in gastric cancer tissues than that in normal tissues. Overexpression of AEG-1 was found in 62.9% of gastric cancers and significantly associated with TNM stage and Ki-67 proliferation index (P < 0.01). For survival study, overexpression of AEG-1 was significantly associated with poor survival (P < 0.01). Further multivariate analysis suggest... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3386318 Fri, 19 Mar 2010 06:52:31 +0100 3386318 http://www.medworm.com/index.php?rid=3386317&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff356xt0nh4gg8332%2F We report the case of a patient with painless acute pancreatitis associated with sorafenib treatment. The patient was a 71-year-old man who had undergone surgery for left renal carcinoma and tumor thrombus in the inferior vena cava and right atrium (IVC-RA). After a follow-up period of 3 years, he developed right adrenal metastasis and received interferon (IFN)-alpha treatment. One year later, progression of the adrenal metastasis was observed, and he was admitted to a hospital for treatment with sorafenib, which was administered at a dose of 800 mg/day. Two weeks later, he developed painless acute pancreatitis associated with sorafenib treatment. Thereafter, sorafenib treatment was discontinued, and he was treated with conservative therapy. Three weeks later, he was disch... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3386317 Fri, 19 Mar 2010 06:52:31 +0100 3386317 http://www.medworm.com/index.php?rid=3386319&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn242u5u1357w8126%2F Abstract  Cancer of the larynx is the commonest head and neck squamous cell carcinoma. The DJ-1 gene is a novel mitogen-dependent oncogene. Survivin is a structurally unique member of the inhibitors of apoptosis proteins. DJ-1 and survivin play important roles in carcinogenesis. The function of DJ-1, and the relationship between DJ-1 and survivin in laryngeal carcinoma, has never been explored. Small interfering RNAs (siRNAs) directed against the DJ-1 gene were initially transfected into laryngeal carcinoma Hep-2 cells with liposome. The viability of Hep-2 cells was then detected by the MTT assay. The changes in cell-cycle distribution were monitored by flow cytometry. Finally, changes in DJ-1 and survivin genes mRNA and protein levels were evaluated by semi-quantitative RT... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3386319 Fri, 19 Mar 2010 06:52:30 +0100 3386319 http://www.medworm.com/index.php?rid=3386321&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmrh465147v4435m2%2F In this study, the expression of β-catenin in astrocytic glioma tissues with different grade and human normal cerebral tissues was examined using reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. We found a higher expression level of β-catenin in astrocytic glioma patients with high grade in comparison with the normal controls. Additionally, siRNA was transfected into human U251 glioblastoma cells by liposome after the design of siRNA was confirmed to effectively inhibit the expression of β-catenin by RT-PCR. Compared to the control siRNA group, siRNA-mediated knockdown of β-catenin in human U251 cells inhibited cell proliferation, resulted in cell apoptosis, and arrested cell cycle in G 0/G 1. Additionally, downregulation of β-catenin decrease... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3386321 Fri, 19 Mar 2010 06:52:28 +0100 3386321 http://www.medworm.com/index.php?rid=3386320&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw866247261103758%2F Abstract  To analyze the clinical characteristics, diagnosis and treatment of primary peritoneal carcinoma (PPC) and to review the literature, so as to raise the awareness of the disease. Four cases of PPC diagnosed in our department from March 2005 to September 2007 were retrospectively analyzed. Four cases were all treated with platinum-based chemotherapy. They were treated with intraperitoneal chemohyperthermia (IPCH) with cisplatin, carboplatin or oxaliplatin with a closed sterile circuit of 1,000 ml physiologic saline and inflow temperature is 43°C, while they were receiving high-intensity focused microwave hyperthermia (HIFMH) concomitantly. Intravenous paclitaxel or docetaxel was used in three patients, while cyclophosphamide and adriamycin injection in another ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3386320 Fri, 19 Mar 2010 06:52:28 +0100 3386320 http://www.medworm.com/index.php?rid=3386323&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl8n7vh772gk58500%2F Abstract  The optimal therapy for carcinoma of unknown primary site (CUPS) is still under investigation. In this retrospective trial, we reported the response rates and overall and progression free survival of 23 CUPS patients that were treated with gemcitabine and cisplatin. The mean age of the patients was 54.95 (32–77). Sixteen (69.6%) of them were males and 7(30.4%) females. Totally 109 cycles with a mean of 6 were administered. Thirteen of 23 patients (56.5%) presented with only one metastatic site, and the liver is the most frequent metastatic site (39.1%). Histologic types were adenocarcinoma in 14 patients (60.8%), squamous carcinoma in 1 patient (4.8%), epithelioid cancer in 3 patients (13%) and undifferentiated cancer in 5 patients (21.7%). Three patient achieve... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3386323 Fri, 19 Mar 2010 06:52:27 +0100 3386323 http://www.medworm.com/index.php?rid=3386322&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv887074425566h03%2F Abstract  Cisplatin ototoxicity is a major dose-limiting factor in the treatment of several neoplasms. Dexamethasone and vitamin E are two slow-acting free radical cleaners, and they have been shown to ameliorate nephrotoxicity and endothelial cell damage in animals receiving cisplatin. The purpose of the study was to determine the effectiveness of vitamin E and dexamethasone as an otoprotectant intratympanically. Prospective, randomized controlled trial in the rat model. Wistar rats were sedated using 50 mg/kg intraperitoneal ketamine and 7.5 mg/kg xylazine. Baseline auditory brainstem response (ABR) testing was performed in response to clicks and 4.8-, 12-, 16-kHz tone bursts. After auditory thresholds were determined, the animals received intraperitoneal drug a... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3386322 Fri, 19 Mar 2010 06:52:27 +0100 3386322 http://www.medworm.com/index.php?rid=3386325&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk6454u7vj73jq001%2F Abstract  Runx3 and CHFR genes were defined as tumor suppressor genes in gastric cancer (GC) recently. This paper was to investigate the roles of methylation and expression status of Runx3 and CHFR genes in GC patients. Methylation-specific polymerase chain reaction (MSP) and bisulfite DNA sequencing (BSP) were used to detect methylation status of Runx3 and CHFR genes in GC patients. The expression of Runx3 and CHFR in GC patients was analyzed by reverse transcription polymerase chain reaction (RT–PCR) and immunohistochemical analysis. The expression of the protein and mRNA decreased remarkably in the patients with aberrant promoter methylation of Runx3 and CHFR genes. The methylation status of Runx3 and CHFR were inversely related to the tumor size, tumor invasion depth ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3386325 Fri, 19 Mar 2010 06:52:25 +0100 3386325 http://www.medworm.com/index.php?rid=3386324&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fut002r42r61v4127%2F Abstract  Rho and Rho-associated kinase play an important role in focal adhesion, stress fiber formation and cell motility. Fasudil is a kind of Rho kinase inhibitor. The effect and precise molecular mechanism of fasudil on the biology behavior of lung cancer cell A549 remains unclear. The cytotoxic effect of fasudil on A549 cell was measured by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Wound-healing assay was used to evaluate the effect of fasudil on migration activity of A549 cells. The invasion activity of A549 cells was detected by transwell chamber assay. The expression of MMPs was measured by gelatin zymography. RT-PCR and western blot were used to investigate the molecular change of A549 cells after treated with fasudil. Fasudil-inhibi... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3386324 Fri, 19 Mar 2010 06:52:25 +0100 3386324 http://www.medworm.com/index.php?rid=3380052&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl071774j361wx47r%2F In this study, PTEN promoter status and its correlation with genetic and pathologic parameters were analyzed in genomic DNA from Iranian patients with breast cancer. DNA methylation patterns in the CpG islands were determined by a methylation-specific PCR (MSP) assay. PTEN promoter methylation was found to be present in 37 of 53(70%) tumor tissues and none in 20 normal counterparts. Moreover, promoter methylation was found in patients with heterozygote mutation in the PTEN gene. The pathological history of cancerous tissue sections showed that PTEN gene could be inactivated at the stages III and IV in sporadic breast cancer. These findings suggested that promoter hypermethylation of PTEN might contribute to the progression of sporadic breast cancer in human. Content Type Journal A... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3380052 Wed, 17 Mar 2010 15:51:54 +0100 3380052 http://www.medworm.com/index.php?rid=3380051&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl5k65j7527n2h4m4%2F This study was designed to evaluate the expression of C-erbB-2 and p16 in lung cancers using tissue microarray technology and to determine their clinical and pathological significance. Immunohistochemical C-erbB-2 and p16 expressions and their associations with clinical and pathological features were analyzed in two tissue microarrays. The membranous and cytoplasmic expression rates of C-erbB-2 were 40.5 and 66.5% in non-small cell lung cancers (NSCLCs), and 0 and 9.5% in small cell lung cancers (SCLCs), respectively. The nuclear and cytoplasmic expression rates of p16 were 11.5 and 32.2% in NSCLs, and 45 and 80% in SCLCs, respectively. The cytoplasmic expression of both C-erbB-2 and p16 was more frequent than the membranous expression of C-erbB-2 and the nuclear expression of p16. T... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3380051 Wed, 17 Mar 2010 15:51:54 +0100 3380051 http://www.medworm.com/index.php?rid=3380053&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl444h531j3u34130%2F Abstract  We sought to improve the understanding of oncogene-dependent and independent non-small-cell lung cancer (NSCLC), which could provide insight into mechanism of sensitivity and/or resistance to tyrosine kinase inhibitors or chemotherapeutics. NSCLC cell lines with different EGFR genotypes were used in this study; MTT assay and flow cytometry were applied to study the sensitivities of these cell lines to gefitinib and cisplatin. Western blot was performed to determine the expression levels of BIM and other Bcl-2 family proteins pre- and pro-treatment. Gefitinib provoked apoptosis of caspase activation via the intrinsic pathways and significantly up-regulated expression of BIM protein in drug-sensitive PC-9 cell line, but not resistant PC-9/BB4 cell line. The knockdow... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3380053 Wed, 17 Mar 2010 15:51:53 +0100 3380053 http://www.medworm.com/index.php?rid=3380054&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu3967j2475769178%2F Abstract  This prospective, single-arm study utilized alemtuzumab as a single agent in a novel maintenance schedule in previously treated chronic lymphocytic leukemia patients with the goal of delaying progression of disease and requirement for chemotherapy. In previously treated CLL patients who had achieved stable disease or better, the following schedule of subcutaneous alemtuzumab was administered: a dose escalation in the first week (3, 10 and 30 mg), followed by 7 weeks of 30 mg alemtuzumab once weekly, 16 weeks of 30 mg once every 2 weeks, followed by once every 3 weeks for 24 weeks. Thus, the entire duration of the planned treatment was 48 weeks. A total of 12 patients were enrolled 11 of which had at least one marker of p... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3380054 Wed, 17 Mar 2010 15:51:51 +0100 3380054 http://www.medworm.com/index.php?rid=3360386&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F31618r5622v16g11%2F In this study, we used an adenovirus(Ad)-mediated transfer of siRNA against bFGF mRNA (Ad-bFGF-siRNA) to study the effect of down-regulating bFGF expression on the sensitivity of glioma cells to chemotherapeutics. An optimal siRNA sequence specific for bFGF mRNA was cloned into an adenoviral vector and transfected into three glioma cell lines: U251, A172, and LN229. Methyl thiazolyl tetrazolium (MTT) assays were used to examine changes in cell proliferation, and changes in bFGF mRNA and protein levels in U251 cells were detected using quantitative RT-PCR and Western blot, respectively. Apoptosis of U251 cells was detected using Hoechst staining and flow cytometry, with expression of apoptosis-related proteins evaluated by Western blot. Following the transfection of a bFGF-specific si... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3360386 Thu, 11 Mar 2010 02:49:32 +0100 3360386 http://www.medworm.com/index.php?rid=3355672&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd5m70715hl604gv2%2F Abstract  The use of targeted/biologic therapies is now commonplace in the treatment of malignant and non-malignant diseases. The novel mode of action of these drugs has resulted in unpredictable and in some cases unexpected side effects. Given the widespread use of bevacizumab and its distinct mode of action, it is important that oncologists report any unexpected adverse events that may be associated with the drug. Herein, we report three cases of spontaneous nasal septum perforation secondary to bevacizumab. We hypothesize an etiology for this rare event and reasons why it is reasonable to rechallenge the patient. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-010-9464-9Authors Derek G. Power, Memorial Sloan Kettering Cancer Center Department o... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3355672 Wed, 10 Mar 2010 16:02:59 +0100 3355672 http://www.medworm.com/index.php?rid=3355673&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F53336175623085t4%2F This study shows a lack of direct involvement of metastin in the diagnosis and metastatic potential of NSCLC. Content Type Journal ArticleCategory Original paperDOI 10.1007/s12032-010-9466-7Authors Eleni M. Karapanagiotou, Athens School of Medicine, Sotiria General Hospital Oncology Unit, Third Department of Medicine Building Z, Mesogion 152 Athens 115 27 GreeceKalliopi D. Dilana, Athens School of Medicine, Sotiria General Hospital Oncology Unit, Third Department of Medicine Building Z, Mesogion 152 Athens 115 27 GreeceIoannis Gkiozos, Athens School of Medicine, Sotiria General Hospital Oncology Unit, Third Department of Medicine Building Z, Mesogion 152 Athens 115 27 GreeceIoannis Gratsias, Athens School of Medicine, Sotiria General Hospital Oncology Unit, Third Department of Medi... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3355673 Wed, 10 Mar 2010 16:02:58 +0100 3355673 http://www.medworm.com/index.php?rid=3355675&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F471u65n70562j8nt%2F This article will review the current role for thalidomide, lenalidomide, and bortezomib-based combinations, as well as some preliminary findings for promising investigational agents currently in clinical trials for patients with relapsed and/or refractory disease. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9407-5Authors Tiffany Richards, MD Anderson Cancer Center Houston TX USADonna Weber, MD Anderson Cancer Center Houston TX USA Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3355675 Wed, 10 Mar 2010 16:02:56 +0100 3355675 http://www.medworm.com/index.php?rid=3355674&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc75203j620741780%2F Abstract  The aim of this study is to conduct a comparison study between the efficacy and safety of zoledronic acid and clodronate in malignant hypercalcemia secondary to bone metastases in Egyptian adult patients. This is a prospective observational study conducted 80 patients (40 in each group), who were assigned to receive either zoledronic acid (4 mg over a 30 min infusion) every 3–4 weeks or clodronate (a single dose of 1,500 mg over a 4 h infusion) monthly for 3 months. The primary efficacy analysis was the proportion of patients with at least one skeletal-related event. The safety was assessed based on the frequencies of the reported adverse effects as nausea, vomiting, anemia, etc. The calcium level significantly decreased in both grou... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3355674 Wed, 10 Mar 2010 16:02:56 +0100 3355674 http://www.medworm.com/index.php?rid=3355676&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk7r8827128491w91%2F We report an APL patient treated with the AIDA regimen, who experienced both early and late DS, a situation where differential diagnosis was difficult. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-010-9462-yAuthors Ramzi Jeddi, Aziza Othmana University Hospital Hematology Department Tunis TunisiaHela Ghédira, Aziza Othmana University Hospital Hematology Department Tunis TunisiaRamzi Ben Amor, Aziza Othmana University Hospital Hematology Department Tunis TunisiaSamia Menif, Institut Pasteur Tunis TunisiaZaher Belhadjali, Aziza Othmana University Hospital Hematology Department Tunis TunisiaBalkis Meddeb, Aziza Othmana University Hospital Hematology Department Tunis Tunisia Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medi... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3355676 Wed, 10 Mar 2010 16:02:55 +0100 3355676 http://www.medworm.com/index.php?rid=3355677&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa3j3302kk48111kx%2F Abstract  A clinical prognostic model derived from BR.21 trial was established by Florescu et al., which helped to identify a small group of patients with non-small cell lung cancer (NSCLC) who might be less likely to benefit from erlotinib therapy. Whether the prognostic model derived from Caucasian patients treated with erlotinib will be applied to Asian patients treated with gefitinib is still an open question. We reviewed a multi-center clinical trial of Chinese patients with NSCLC treated with gefitinib. The data were collected and analyzed according to the prognostic model reported by Florescu et al. One hundred and nineteen patients were included in the validation study. Twenty-eight patients, 61 patients, 27 patients, and 3 patients were classified into the Low Risk... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3355677 Wed, 10 Mar 2010 16:02:54 +0100 3355677 http://www.medworm.com/index.php?rid=3355678&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2886m750268152g4%2F In conclusion, determination of 1236T, C3435T, and G2677T MDR1 polymorphisms might be useful in response prediction to therapy with imatinib in patients with CML. Content Type Journal ArticleCategory Original paperDOI 10.1007/s12032-010-9456-9Authors Ling-Na Ni, Nanjing Medical University Department of Hematology, Jiangsu Province Hospital, The First Affiliated Nanjing Medical University Hospital 300 Guangzhou Rd 210029 Nanjing ChinaJian-Yong Li, Nanjing Medical University Department of Hematology, Jiangsu Province Hospital, The First Affiliated Nanjing Medical University Hospital 300 Guangzhou Rd 210029 Nanjing ChinaKou-Rong Miao, Nanjing Medical University Department of Hematology, Jiangsu Province Hospital, The First Affiliated Nanjing Medical University Hospital 300 Guangzhou R... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3355678 Wed, 10 Mar 2010 16:02:53 +0100 3355678 http://www.medworm.com/index.php?rid=3336463&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F260513201524110n%2F This study was designed to evaluate the efficacy and safety of irinotecan in combination with carboplatin in previously untreated, extensive-disease small-cell lung cancer (ED-SCLC). Patients with histologically or cytologically confirmed ED-SCLC received irinotecan (60 mg/m2 on days 1, 8, and 15) plus carboplatin (AUC 5 on day 1) every 4 weeks. Treatment was repeated until disease progression, unacceptable toxicity, or up to 6 cycles. Forty-four patients were enrolled. In an intent-to-treat analysis, the overall response rate (RR) was 75% (8 complete responses and 25 partial responses). The median progression-free (PFS) and overall survival (OS) were 5.6 and 8.7 months, respectively. The principle toxicities were neutropenia and diarrhea. Grade 3–4 neutropenia occur... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3336463 Wed, 03 Mar 2010 08:07:29 +0100 3336463 http://www.medworm.com/index.php?rid=3328335&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F62k0h72t77p10v84%2F Abstract  There are many controversies regarding the treatment of very early-stage (pT1a/bN0M0) breast cancer (BC), generally considered to have a very good prognosis. The debate is the benefit of an adjuvant treatment of HER2-neu (namely HER-2)-positive subcentimetric carcinoma with trastuzumab. Current guidelines do not suggest, with the highest level of evidence, whether trastuzumab should be administered after adjuvant chemotherapy in the treatment of high-risk pT1a/bN0M0 breast cancer. The major phase III trials that confirmed the benefit of adjuvant immunotherapy did not include small (<1 cm diameter) node-negative breast cancer. Several retrospective case series of HER-2-positive pT1a/bN0M0 carcinoma seem to demonstrate that they have a higher risk of relapse ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3328335 Tue, 02 Mar 2010 10:07:46 +0100 3328335 http://www.medworm.com/index.php?rid=3328334&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn47l0727755jv323%2F This study indicates that lower serum level of estradiol may represent higher predisposition for development of ESCC, and ERβ expression and/or nuclear location may predict better outcome for patients with ESCC. The present results provide clues to explain the striking gender difference for ESCC, which warrants further investigations on potential applications of estrogen or analogs in prevention of ESCC. Content Type Journal ArticleCategory Original paperDOI 10.1007/s12032-010-9457-8Authors Qi-Ming Wang, Zhengzhou University Department of Oncology, The First Affiliated Hospital 450052 Zhengzhou, Henan People’s Republic of ChinaYi-Jun Qi, Henan University Key Laboratory of Cellular and Molecular Immunology, Institute of Immunology, College of Medicine 475000 Kaifeng, Henan Peop... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3328334 Tue, 02 Mar 2010 10:07:46 +0100 3328334 http://www.medworm.com/index.php?rid=3328336&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm47540128544n224%2F In conclusion, our meta-analysis demonstrates that CYP2E1 Rsa I/Pst I c2 allele may be a decreased risk factor for developing esophageal cancer among Asians populations. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-010-9455-xAuthors Yuming Niu, Nanjing Medical University Institute of Dental Research 140 Hanzhong Road 210029 Nanjing People’s Republic of ChinaHua Yuan, Nanjing Medical University Institute of Dental Research 140 Hanzhong Road 210029 Nanjing People’s Republic of ChinaWeidong Leng, Taihe Hospital, Yunyang Medical College Department of Stomatology 32 South Renmin Road 442000 Shiyan People’s Republic of ChinaYongchu Pang, Nanjing Medical University Institute of Dental Research 140 Hanzhong Road 210029 Nanjing People’s Republic of ChinaNing... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3328336 Tue, 02 Mar 2010 10:07:45 +0100 3328336 http://www.medworm.com/index.php?rid=3308148&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F50023476n2179lg4%2F Abstract  We retrospectively analyzed 294 patients with primary soft tissue sarcoma followed between 1996 and 2002 in Ankara Oncology Hospital. There were 170 male and 124 female patients with the age range of 16–80 years. The primary tumor was in the extremity in 72.9% of the patients. We determined lung metastasis in 102 (85%) out of the 120 patients as distant metastasis. The most common adult sarcomas were liposarcoma (16.3%), malignant mesenchymal tumor (MMT) (13.9%), malignant fibrous histiocytoma (MFH) (11.2%), rhabdomyosarcoma (10.2%) and synovial sarcoma (10.2%). Seventeen patients (5.3%) had grade 1 tumor, 143 patients (52.2%) had grade 2 tumor, and 112 patients (41.4%) had grade 3 tumor. In 45 patients (15.3%), the grade of the tumors is unknown. The tumor... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3308148 Wed, 24 Feb 2010 06:55:43 +0100 3308148 http://www.medworm.com/index.php?rid=3291553&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F31t17juq27u75338%2F Abstract  Multiple myeloma is a clonal B-cell malignancy characterized by aberrant expression of plasma cells wtihin the bone marrow, and is associated with the well known clinical manifestations anemia, bone disease, renal dysfunction, hypercalcemia, and recurrent infections. For many years, melphalan and prednisone represented the standard of care in multiple myeloma therapy, with stem cell transplantation reserved for selected patients. Treatment of the disease has evolved rapidly over the past decade, however, with the development and utilization of thalidomide, lenalidomide, and bortezomib. As a result of these developments, clinical outcomes have improved significantly. This review highlights important historic landmarks as well as more recent events that have played ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3291553 Fri, 19 Feb 2010 06:44:43 +0100 3291553 http://www.medworm.com/index.php?rid=3291554&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2852448766666312%2F Abstract  Brucellosis is a zoonotic disease and endemically seen in the Middle East, Eastern Europe and continental America. Febrile neutropenia related to Brucellosis has been reported only in a few cases. Brucella was cultured from the bone morrow of a 42-year-old woman who was admitted to hospital with symptoms of fever and fatigue and later diagnosed as acute myeloblastic leukemia (AML). The patient was treated for both AML and Brucellosis without any problems and discharged from the hospital after scheduling her follow-up visits. Brucellosis might be considered in the etiology of febrile neutropenia in endemic regions and must be treated effectively to prevent possible morbidity and mortality during or after chemotherapy. Content Type Journal ArticleCategory Origin... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3291554 Fri, 19 Feb 2010 06:44:41 +0100 3291554 http://www.medworm.com/index.php?rid=3289102&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh352683up8307566%2F Abstract  Ginseng polysaccharide has anticancer activity. However, the structure–activity relationship and the activity mechanism are still unclear. Therefore, it is necessary to study the anticancer activity of structurally different ginseng polysaccharide fractions and their potential mechanisms. Ginseng polysaccharide fractions and their temperature-modified products were assayed for their effects on HT-29 cell proliferation by MTT assay, on cell cycle progression by flow cytometry, and on caspase-3 activation by western blot analysis. The HG-rich ginseng pectin inhibited cell proliferation and induced cell cycle arrest in the G2/M phase. The temperature-modified HG-rich pectin had dramatically increased antiproliferative effect and induced apoptosis accompanied by the... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3289102 Thu, 18 Feb 2010 06:53:01 +0100 3289102 http://www.medworm.com/index.php?rid=3289103&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1w1428tt54860436%2F In conclusion, these algorithms can be used effectively in Chinese patients with DLBCL. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-010-9433-3Authors Zi Chen, Fudan University Department of Hematology, Huashan Hospital 200040 Shanghai ChinaZunguo Du, Fudan University Department of Pathology, Huashan Hospital 200040 Shanghai ChinaJieqing Chen, The University of Texas M.D. Anderson Cancer Center Department of Melanoma Houston TX 77030 USAZhongqing Chen, Fudan University Department of Pathology, Huashan Hospital 200040 Shanghai ChinaYun Bao, Fudan University Department of Pathology, Huashan Hospital 200040 Shanghai ChinaFeng Tang, Fudan University Department of Pathology, Huashan Hospital 200040 Shanghai China Journal Medical OncologyOnline ISSN 1559-1... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3289103 Thu, 18 Feb 2010 06:53:00 +0100 3289103 http://www.medworm.com/index.php?rid=3273560&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft1617027g3576677%2F Abstract  Thymic hyperplasia is a common phenomenon in both children and young adults after chemotherapy and may explain the finding of a mediastinal mass in patients with malignant lymphoma after complete remission. In the present study, we report 5 cases with malignant lymphoma presenting with a mediastinal mass on CT scan after completion of chemotherapy diagnosed as thymic hyperplasia by PET-CT imaging. We retrospectively analyzed 5 patients who presented with anterior mediastinal masses a median of 4 months (range 3–6) after achieving complete remission following successful treatment for malignant lymphoma. Three patients were diagnosed with Hodgkin’s lymphoma (HL) and the others with non-Hodgkin’s lymphoma (NHL). The median age of the patients was 23 (range... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3273560 Sat, 13 Feb 2010 06:51:39 +0100 3273560 http://www.medworm.com/index.php?rid=3270410&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F898188p10771j5u3%2F Abstract  The aim of this study is to evaluate influence of allogeneic blood transfusion on prognosis in patients in Dukes B stage of colorectal cancer. All patients with colorectal cancer who were admitted at our Department of Surgery between January 2000 and December 2004 were analyzed. One hundred fifty-one patients who fulfilled inclusion criteria were enrolled in further evaluation. B stage according to Dukes classification and curative resection were inclusion criteria. Exclusion criteria were polyposis syndromes, nonpolyposis syndromes, inflammatory bowel disease, autoimmune disease and previous blood transfusion. Patients were divided into two groups: Group 1 received ≤3 units of allogeneic blood transfusion and group 2 received >3 units of allogeneic blood tra... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3270410 Fri, 12 Feb 2010 07:32:50 +0100 3270410 http://www.medworm.com/index.php?rid=3270411&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp842522x7440w641%2F In this study, we also found that NHE1 is over-expressed in HCC cell lines. Subsequently, we silenced NHE1 expression in the human HCC cell line SMMC-7721 using RNA interference (RNAi) and examined the invasiveness and proliferation of NHE1-silenced SMMC-7721 cells and the matrix metalloproteinase-2 (MMP-2) activity. The knockdown of NHE1 expression significantly inhibited the invasive ability of SMMC-7721 cells but had only a minor effect on the cellular proliferation rate. Moreover, NHE1 knockdown significantly reduced the secretion of MMP-2. Further experiment using amiloride (an inhibitor of NHE1) confirmed the above result. Together, these findings indicate that NHE1 has an important role in SMMC-7721 cell invasion and that NHE1 might be a new target of HCC treatment. Content... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3270411 Fri, 12 Feb 2010 07:32:48 +0100 3270411 http://www.medworm.com/index.php?rid=3263918&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5n8j22p0281604g1%2F The objective of the current study was to assess the prognostic significance of telomerase activity, serum anti-p53 antibodies (anti-p53a), c-erbB-2 and CEA in patients with NSCLC. The study included 60 patients with histological proven NSCLC besides 60 controls (30 smokers and 30 nonsmokers). Patients were divided into four stages according to their histopathology. All patients were subjected to; determination of telomerase activity by telomeric repeat amplification protocol (TRAP) assay in tumor tissue specimens and adjacent normal lung tissues, also, determination of preoperative serum anti-p53a, c-erbB-2 and CEA. Telomerase activity was detected in 40 of 60 (66.6%) of NSCLC tissue specimens using the TRAP assay. As regard the stages, telomerase activity was positive in 5 of 15 p... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3263918 Wed, 10 Feb 2010 06:50:14 +0100 3263918 http://www.medworm.com/index.php?rid=3263920&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgu66wn4u5g212h60%2F Abstract  Esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed malignant tumors in North China. We have identified that Wnt2/β-catenin pathway is activated in ESCC cells and sodium nitroprusside (SNP) and siRNA against β-catenin not only inhibit the expressions of β-catenin and its major downstream effectors including c-myc and cyclin D1 but induce cell cycle arrest and apoptosis. The purpose of the present study was to analyze the relationship between pathological parameters including invasion depth and lymph node metastasis and the expressions of β-catenin, c-myc, and cyclin D1 in order to evaluate their values of prognosis in patients with ESCC. The expressions of β-catenin, c-myc, and cyclin D1 were detected immunohistochemically in the... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3263920 Tue, 09 Feb 2010 06:48:27 +0100 3263920 http://www.medworm.com/index.php?rid=3263919&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq1p7gn23264j7235%2F Abstract  The published data on the predictive value of polymorphism of ERCC1 and XPD in patients with advanced non-small cell lung cancer receiving platinum-based chemotherapy are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Relevant studies were identified by searching the Medline, Embase, CNKI and American Society of Clinical Oncology abstract databases. Inclusion criteria were patients with advanced NSCLC, received platinum-based chemotherapy, evaluation of polymorphism of ERCC1 and XPD and overall response rate (ORR). A total of 12 studies were included in this meta-analysis. For studies evaluating ERCC1 polymorphism at codon 118, the ORR for the wild-type C/C genotype versus the heterozygous C/T and T/T genotype... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3263919 Tue, 09 Feb 2010 06:48:27 +0100 3263919 http://www.medworm.com/index.php?rid=3263921&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy7870t0744282181%2F Abstract  MicroRNAs (miRNAs) are endogenous small noncoding RNA molecules involved in modulation of cellular sensitivity to anti-cancer drugs. miRNA-21 (miR-21), one of the most prominent miRNAs in the genesis and progression of many human cancers, has been rarely characterized in myelogenous leukemia. Arsenic trioxide (ATO) was successfully used in the treatment of acute promyelocytic leukemia (APL) etc. However, cytotoxicity or insensitivity is a major concern in the successful treatment of leukemia. Here, we used a specific precursor miRNA-21 (pre-miR-21) or anti-miRNA-21 oligonucleotide (AMO-miR-21) to study sensitivity of HL60 and K562 cells to ATO. Cell viability and cell cycle were evaluated by MTT assay and PI assay using flow cytometry, respectively. Levels of miR-... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3263921 Tue, 09 Feb 2010 06:48:26 +0100 3263921 http://www.medworm.com/index.php?rid=3263922&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpx77126871675563%2F Abstract  Gastric adenocarcinomas may be seen together with colon, prostate, breast, liver, lung and gynecological malignancies as synchronous or metachronous cancer. However, Hodgkin’s lymphoma (HL) is rarely diagnosed with solid tumors. Herein, a 72-year-old man with both gastric adenocarcinoma and HL has been presented. Mass lesions far away from the primary tumor in cancer patients can be not only the sign of distant metastasis but also another primary malignancy. In the English literature, synchronous gastric adenocarcinoma and HL has been rarely reported, and as far as we know, this is the third case to be reported. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-010-9439-xAuthors Ü. Yalçıntaş Arslan, Ankara Oncology Education and Resear... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3263922 Tue, 09 Feb 2010 06:48:25 +0100 3263922 http://www.medworm.com/index.php?rid=3255858&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgx466512149q138m%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s12032-010-9437-zAuthors Ozgur Kara, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye Ankara 06100 TurkeyEvren Ozdemir, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye Ankara 06100 TurkeyCagatay Arslan, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye Ankara 06100 TurkeyErkan Dogan, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye Ankara 06100 TurkeyKadri Altundag, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye Ankara 06100 Turkey Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3255858 Sat, 06 Feb 2010 08:23:40 +0100 3255858 http://www.medworm.com/index.php?rid=3247914&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu203n6k4555011t1%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s12032-010-9438-yAuthors Azhar B. Ali, National University of Singapore Cancer Science Institute (CSI) Singapore 28 Medical Drive, Centre for Life Sciences (CeLS) Singapore 117456 SingaporePhilip T. C. Iau, National University Hospital Department of Surgery Singapore SingaporeJen-Hwei Sng, National University of Singapore Department of Surgery, Yong Loo Lin School of Medicine Singapore Singapore Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3247914 Fri, 05 Feb 2010 08:14:18 +0100 3247914 http://www.medworm.com/index.php?rid=3247915&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk248551683367336%2F Abstract  JAK/STAT pathway transmits signals from the cell membrane to the nucleus in response to extracellular growth factors and cytokines. Activation of this pathway has been found in certain types of human tumors. The goal of this study was to investigate the correlation between the JAK/STAT pathway in human gliomas and patients’ prognosis, which currently is unknown. Western blotting analysis and immunohistochemical staining were performed to detect JAK-1, phosphorylated JAK-1, and STAT-3 expression patterns in the biopsies from 96 patients with primary gliomas. Kaplan–Meier survival and Cox regression analyses were performed to evaluate the prognosis of patients. Western blotting analysis and immunohistochemical staining both indicated that the expression levels o... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3247915 Fri, 05 Feb 2010 08:14:12 +0100 3247915 http://www.medworm.com/index.php?rid=3240909&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff0554nu87326231t%2F Abstract  Curcumol isolated from Rhizoma Curcumae, a common traditional Chinese medicine, has been reported to possess antitumor effects, but little is known about the molecular mechanism. The current study tried to explore the molecular mechanism of curcumol-induced cell death in human lung adenocarcinoma (ASTC-a-1) cells. Cell counting kit (CCK-8) assay, fluorescence resonance energy transfer (FRET), confocal fluorescence microscopy imaging, emission spectral analysis, and flow cytometry (FCM) technologies were used to assess the characteristics of curcumol-induced cell death. FCM analysis showed that curcumol induced G2/M phase arrest, nuclear fragmentation and phosphatidylserine externalization, implying that curcumol dominantly induced apoptotic cell death. Dynamical im... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3240909 Wed, 03 Feb 2010 06:56:09 +0100 3240909 http://www.medworm.com/index.php?rid=3240910&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F543w78m77gv01475%2F Abstract  The degradation product of collagen type I carboxy terminal telopeptide (ICTP) represents a new biochemical parameter that reflects the changes in the resorption properties of skeletal system. Affection of the skeleton is one of the most important characteristics of multiple myeloma (MM). We estimated significance of ICTP as osteolysis predictor and overall survival in comparison with standard prognostic parameters β2-microglobulin and C-reactive protein (CRP), in patients with MM. With our results, we have shown significant difference in serum level of ICTP (P = 0.009) between patients with and without osteolysis on conventional radiography. It was proved that ICTP is the most significant predictor of osteolysis (P = 0.09), while CRP is the mo... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3240910 Tue, 02 Feb 2010 07:00:59 +0100 3240910 http://www.medworm.com/index.php?rid=3228569&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm3302142g524r606%2F We present a 69-year-old male patient of gastric carcinoma with PP. The literature is reviewed, clinical and histological features of the case are discussed. This is the first case of PP in a gastric carcinoma patient reported in literature. As a conclusion, PP can be the first manifestation of a pancreatic metastasis of any carcinoma. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-010-9420-8Authors H. Beyazıt, American Hospital Dermatology Department Güzelbahçe sok. No. 20 34365 Istanbul Nişantaşı TurkeyO. Aydin, ETA Pathology Lab Akkavak Sok. Dilek Ap No. 22/3 34365 Tesvikiye Istanbul TurkeyC. Demirkesen, ETA Pathology Lab Akkavak Sok. Dilek Ap No. 22/3 34365 Tesvikiye Istanbul TurkeyD. Derin, American Hospital Medical Oncology Department Güzelbahçe... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3228569 Sat, 30 Jan 2010 18:16:18 +0100 3228569 http://www.medworm.com/index.php?rid=3223979&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy9560732200tp1wq%2F Abstract  The p27Kip1 cyclin-dependent kinase inhibitor is a negative regulator of cell cycle progression in G1 phase; recent studies suggested that oncogenically activated kinase Akt/PKB can also phosphorylate p27kip1 at T157 inducing its relocalization to the cytoplasm. To evaluate the significance of p-p27 Thr157 and PI3K pathway in hepatocellular carcinoma (HCC), we studied 51 hepatocellular carcinomas along with corresponding nontumoral tissue and the HCC cell lines. Immunohistochemistry and western blot analysis suggested that p-p27 Thr157 was overexpressed in HCC, which was positively correlated with proliferation marker Ki-67. Correlation analysis was performed among immunohistochemistry-assessed level of p-p27 Thr157, survival, and major clinical and pathological var... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3223979 Thu, 28 Jan 2010 06:54:00 +0100 3223979 http://www.medworm.com/index.php?rid=3223981&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd3568148m8764574%2F This study was designed to examine the role of autophagy in the death of human acute promyelocytic leukemia NB4 cells initiated by arsenic trioxide. Furthermore, the effects of autophagy inhibition and augmentation on cell viability were also compared. Our data suggested that both augmentation and suppression of autophagy could enhance the treatment effects while the latter was preferable. This study indicated that autophagy regulation augmented the treatment effects initiated by arsenic trioxide in NB4 cells, and that the selection of regulator should be precisely considered. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-010-9430-6Authors YaLi Ren, Peking University First Hospital Lab of Electron Microscopy No. 8 Xishiku Street, XiCheng District 100034 Bei... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3223981 Wed, 27 Jan 2010 20:00:24 +0100 3223981 http://www.medworm.com/index.php?rid=3223980&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw20xh8w4k8327g75%2F Abstract  Patients with cancer may suffer from malnutrition due to cachexia, this maybe secondary to treatment, psychological factors and/or gastrointestinal (GI) obstruction. GI obstruction indicates a need for TPN. Does this apply to patients with incurable terminal cancer? How does TPN affect longevity and quality of life in this group of patients? What is the course of TPN treatment compared with patients receiving TPN due to nonmalignant GI failure (NMGIF). The aim of this work was to help define the role of TPN in patients with incurable cancer and GI obstruction. Data of all patients treated by home TPN (HTPN) 2003–2009 were collected prospectively and analyzed. Sixty-eight patients were treated with HTPN, 30 of them for NMGIF. Mean age was 52 years (37–87).... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3223980 Wed, 27 Jan 2010 20:00:24 +0100 3223980 http://www.medworm.com/index.php?rid=3223983&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv11m3u1m3114n152%2F We report a 50-year-old man who presented with the sudden onset of severe abdominal pain. Computerized tomography (CT) demonstrated a huge homogeneous tumor in the lower abdomen that appeared to be in continuity with the distal ileum. The mass adherent to the ileum was resected and proved to be a desmoid tumor. The patient has remained recurrence free on follow-up. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-010-9429-zAuthors Ching-Wei Chang, Mackay Memorial Hospital, Mackay Medicine, Nursing and Management College Division of Gastroenterology, Department of Internal Medicine No. 92, Sec. 2, Chung Shan North Road Taipei TaiwanTsang-En Wang, Mackay Memorial Hospital, Mackay Medicine, Nursing and Management College Division of Gastroenterology, Department of... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3223983 Wed, 27 Jan 2010 20:00:23 +0100 3223983 http://www.medworm.com/index.php?rid=3223982&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F560368210511075q%2F In conclusion, increased expression of VEGF-A and VEGF-C in marginal portion of colorectal cancer was correlated with lymph node metastasis. VEGF-C facilitates colorectal cancer cells invade into peritumoral lymphatic vessels, and different mechanisms may exist in the invasion of tumor cells into peritumoral and intratumoral lymphatic vessels. Assessment the expression of both VEGF-A and VEGF-C in the marginal portion of tumor may help to identify patients with colorectal cancer with unfavourable overall survival. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-010-9427-1Authors Mei Lin, Qingdao Municipal Hospital Laboratory Medicine Qingdao ChinaHui-zhong Lin, Qingdao Municipal Hospital Department of Surgery Qingdao ChinaShu-pei Ma, Qingdao Municipal Hospita... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3223982 Wed, 27 Jan 2010 20:00:23 +0100 3223982 http://www.medworm.com/index.php?rid=3223984&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc878r4gu781v5441%2F Abstract  ESA-10 is an embryonic antigen expressed by tumor cells. A method to detect the antigen in the blood based on alterations in the erythrocyte sedimentation rate that occur when antiserum to ESA-10 is bound to the antigen in blood was devised and used here to determine the sensitivity and predictive value of the test in patients with biopsy proven non-hematologic malignancies, and in normal control subjects. The test was positive in 22 of 24 cancer patients tested, and negative in 30 of 35 control subjects. Of the five positive control subjects, one female had recently given birth and was lactating. Another control subject was recently diagnosed with prostate cancer, just months after having participated in this study. Therefore, this tumor marker test (Turtest®) h... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3223984 Wed, 27 Jan 2010 20:00:22 +0100 3223984 http://www.medworm.com/index.php?rid=3223985&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk42r164t52517588%2F Abstract  Although antigen-specific immune responses including cytotoxic T cells (CTLs) against antigen peptide could be enhanced after tumor antigen peptide vaccinations, the immune responses do not necessarily result in a decrease or eradication of tumor cells in the vaccination trials. We focused on whether antigen-specific CTLs could be damaged by the repeated stimulation of antigenic peptide and whether regulatory T (Treg) cells would be increased by the administration of WT1 peptide. We administered WT1 peptide 22 times over 18 months in a CML patient who was being treated with imatinib. Although WT1 peptide administration every 2 weeks did not show any beneficial effects on the minimal residual disease (copies of bcr-abl transcripts), the transcripts remark... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3223985 Wed, 27 Jan 2010 20:00:21 +0100 3223985 http://www.medworm.com/index.php?rid=3205717&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1715276u15756059%2F In conclusion, the NAT1 or NAT2 phenotypes detoxify carcinogens and their reactive intermediates are unlikely to be the cause of PCa development. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-010-9423-5Authors Chunming Gong, The First Affiliated Hospital of Guangxi Medical University Department of Urology Nanning, Guangxi Zhuang Autonomous Region 530021 People’s Republic of ChinaXueying Hu, The First Affiliated Hospital of Guangxi Medical University Department of Urology Nanning, Guangxi Zhuang Autonomous Region 530021 People’s Republic of ChinaYong Gao, The First Affiliated Hospital of Guangxi Medical University Department of Urology Nanning, Guangxi Zhuang Autonomous Region 530021 People’s Republic of ChinaYunfei Cao, The First Affiliated Hospital of G... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3205717 Sat, 23 Jan 2010 07:49:13 +0100 3205717 http://www.medworm.com/index.php?rid=3205718&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F812q075704103458%2F Abstract  Recent studies have shown some degrees of discordance in ER, PR and HER-2 immunohistochemical expression between primary and recurrent/metastatic lesions (RML). Analysis was made on 78 patients with MBC whose ER, PR and/or HER-2 status were known both on the tissue samples of primary and RML. Among the RML sites, 29.5% were locoregional, 70.5% were distant metastatic sites. Among 75 patients with known ER expression on both primary and RML, 36% (n = 27) showed discordance on ER expression. Among 72 patients with known PR expression on both primary and RML, 54.2% (n = 39) showed discordance on PR expression. Among 61 patients with known HER-2 expression on both primary and RML, 14.7% (n = 9) showed discordance on HER-2 expression. No diff... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3205718 Sat, 23 Jan 2010 07:49:12 +0100 3205718 http://www.medworm.com/index.php?rid=3205719&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fer5445v11l541217%2F We report a case of a 66-year-old Taiwanese female patient with situs ambiguus diagnosed of pancreatic head cancer. She was treated with gemcitabine and erlotinib and remained in stable disease on follow-up imaging studies. Situs ambiguus is a rare disease and reports of such patients with cancer have rarely been reported in the literature. Our case illustrates that standard chemotherapy in this group of patients may be undergone with promising results. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-010-9421-7Authors Po-Chou Lin, National Yang-Ming University School of Medicine Taiwan Republic of ChinaJiun-I Lai, National Yang-Ming University School of Medicine Taiwan Republic of ChinaCheng-Hwai Tzeng, National Yang-Ming University School of Medicine Taiwan R... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3205719 Fri, 22 Jan 2010 09:56:33 +0100 3205719 http://www.medworm.com/index.php?rid=3194981&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp8217u5j4120245v%2F The objective of this study is to evaluate the clinicopathological features and immunohistochemical characteristics of epithelioid trophoblastic tumor (ETT). Seven cases of epithelioid trophoblastic tumor treated in the Women’s Hospital of Zhejiang University from 2004 September to 2008 December were retrospectively analyzed. Immunohistochemical study was performed. The most common presenting symptom was vaginal bleeding. Four patients had prior evidence of molar pregnancy and three patients presented with metastases. Mean age at diagnosis was 34.7 years. Mean pregnancy interval was 3.39 years. Human chorionic gonadotropin levels were 33.25–174315.5 IU/l. One case died from metastasis in lungs. The remaining six patients survived without recurrence. Immunohistochem... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3194981 Wed, 20 Jan 2010 06:48:06 +0100 3194981 http://www.medworm.com/index.php?rid=3194980&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F86467635011702q1%2F Abstract  Cytotoxic chemotherapy offers a modest benefit for patients with advanced non-small cell lung cancer (NSCLC), with response rates of 20–35% and median survival of 10–12 months. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), gefitinib and erlotinib are active against lung cancer. In retrospective studies, EGFR-TKI therapy among patients harboring EGFR mutations showed response rates higher than 65% and a median survival of 20–30 months. Gefitinib is well tolerated and less toxic compared to conventional cytotoxic drugs, but gefitinib-related interstitial lung disease (ILD) has been reported as a serious adverse effect. Although the mechanism remains unknown, multivariate analysis revealed male sex, history of smoking, and... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3194980 Wed, 20 Jan 2010 06:48:06 +0100 3194980 http://www.medworm.com/index.php?rid=3194982&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp019r51526773416%2F The objective of this study was to quantitatively evaluate the association between IL-10-592 allele polymorphism and gastric cancer susceptibility. We performed an extensive search of relevant studies and made a meta-analysis, including 12 studies with 2,285 gastric cancer cases and 4,236 controls. The combined results based on all studies showed that there were no significant differences in genotype distribution between gastric cancer cases and controls, CC versus CA/AA (OR = 1.05, 95% CI: 0.92–1.18), CC/CA versus AA (OR = 1.16, 95% CI: 0.92–1.46), CC versus CA (OR = 1.03, 95% CI: 0.90–1.17), CC versus AA (OR = 1.10, 95% CI: 0.90–1.34), and CA versus AA (OR = 1.16, 95% CI: 0.92–1.45). When stratifying for the race, it was f... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3194982 Wed, 20 Jan 2010 06:48:05 +0100 3194982 http://www.medworm.com/index.php?rid=3190438&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp0u44565x6j55vk0%2F Abstract  Human papillomavirus (HPV) has been considered to be an etiological agent for anogenital cancers, such as cervical cancer and possibly a subset of cancers of the aerodigestive tract. The aim of the study was to evaluate the presence of human papillomavirus DNA in colorectal carcinomas and adenomas. Formalin-fixed and paraffin-embedded archival tissue samples were used for DNA extraction. One hundred and six colorectal carcinomas and 62 adenomas were screened by nested polymerase chain reaction (PCR) for HPV DNA with a control group of 49 cervical tissues with invasive cervical carcinoma and cervical intraepithelial neoplasia (CIN). In the study group, we did not find HPV DNA positivity in any of all the colorectal carcinomas and adenomas. In the control group with... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3190438 Sat, 16 Jan 2010 06:52:51 +0100 3190438 http://www.medworm.com/index.php?rid=3190440&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F26k647885442738j%2F Abstract  Cyclin D2, P53, Rb and ATM as cell cycle genes regulate cell growth and proliferation. Considering their roles, we assumed that they have different level of mRNA expression in different grades of brain tumors. To determine this point, we investigated the mRNA expression in two types of brain tumors, including astrocytoma and meningioma. The mRNA of 52 brain tumor samples were extracted; cyclin D2, P53, Rb and ATM mRNA expression was quantified using the real-time quantitative reverse-transcription polymerase chain reaction. We compared mRNA expression of these genes between astrocytoma and meningioma tumors and also between different grades of them. Cyclin D2, P53, Rb and ATM had higher expression in astrocytoma than meningioma tumors. Higher grade (III and IV) of... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3190440 Fri, 15 Jan 2010 00:47:54 +0100 3190440 http://www.medworm.com/index.php?rid=3190439&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa044602784l4h282%2F This study compared clinical and pathological characteristics of screen-detected and clinically diagnosed prostate cancers and evaluated the effectiveness of PSA screening for early detection of prostate cancer in Nanjing. Between July 2004 and December 2005, 8,562 men aged ≥50 years were included for PSA screening. Participants with serum PSA ≥4.0 ng/ml were recommended for transrectal ultrasonography (TRUS)-guided prostate needle biopsy (TRNB). During the same period, 82 consecutive clinically diagnosed prostate cancers were included as controls. The clinical and pathological features of the screened versus clinically diagnosed cancers were evaluated. A total of 719 (8.4%) of screened men had PSA levels ≥4.0 ng/ml. Biopsy was performed in 295 men, and 58 prosta... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3190439 Fri, 15 Jan 2010 00:47:54 +0100 3190439 http://www.medworm.com/index.php?rid=3190441&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh7561l4597030350%2F Abstract  Combination chemotherapy of S-1 and cisplatin has shown promising activity against advanced gastric cancer, but the schedules and dose intensities of S-1 and cisplatin have not been consistent in several clinical trials. We investigated the efficacy and toxicity of 3-weekly S-1/cisplatin chemotherapy as first-line treatment in metastatic or relapsed gastric cancer (MRGC). Forty-six patients with MRGC were prospectively enrolled. S-1 (80 mg/m2/day; days 1–14) and cisplatin (60 mg/m2; day 1) were administrated every 3 weeks. Among 46 patients who received chemotherapy, one achieved a complete response and 21 achieved a partial response, resulting in an overall response rate (RR) of 48%. Thirteen patients (28%) had stable disease and eight patients (1... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3190441 Fri, 15 Jan 2010 00:47:52 +0100 3190441 http://www.medworm.com/index.php?rid=3177059&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg2m2m025872v03m2%2F In conclusion, HLA-A2, -A30 and A31 were associated with breast cancer. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9414-6Authors Pooi Pooi Leong, University Putra Malaysia Department of Pathology, Faculty of Medicine and Health Sciences 43400 Selangor MalaysiaRohaizak Muhammad, Universiti Kebangasaan Malaysia Medical Centre Department of Surgery, Faculty of Medicine 56000 Selangor MalaysiaNaqiyah Ibrahim, Universiti Kebangasaan Malaysia Medical Centre Department of Surgery, Faculty of Medicine 56000 Selangor MalaysiaSoon Keng Cheong, Universiti Tunku Abdul Rahman Faculty of Medicine and Health Sciences Bandar Sungei Long 43000 Selangor MalaysiaHeng Fong Seow, Victoria University School of Biomedical and Health Sciences, Faculty of Health, Engineering and... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3177059 Wed, 13 Jan 2010 06:47:31 +0100 3177059 http://www.medworm.com/index.php?rid=3168590&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq283570676343u31%2F Abstract  Primary lymphoma of the heart is extremely rare and almost always occurs in immunodeficient persons. The author reports a very rare autopsy case of primary diffuse large B-cell lymphoma in an immunocompetent woman. A 55-year-old woman presented with chest pain and arrhythmia. Various imaging modalities including US, CT, MRI, and gallium-scintigraphy revealed a mass in the right atrium and pericardial effusion. No tumor formations were recognized in other organs. Pericardial effusion cytology revealed malignant large lymphoid cells of B-cell type positive for CD20. Laboratory data did not reveal immunosuppression, and human immunodeficiency virus was negative. Therefore, a clinical diagnosis of primary heart lymphoma was made. The patient was treated with chemo-rad... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3168590 Tue, 12 Jan 2010 06:48:02 +0100 3168590 http://www.medworm.com/index.php?rid=3168591&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg77t80428773w537%2F Abstract  Colorectal cancer is one of the most common cancers worldwide. The anticancer effect of Wolfberry (Lycium barbarum) polysaccharide (LBP) on colon cancer cells is largely unknown. To investigate the growth effect of LBP on human colon cancer cell and its possible mechanisms, human colon cancer SW480 and Caco-2 cells were treated with 100–1,000 mg/l LBP for 1–8 days. Cell growth was measured by MTT assay and crystal violet assay. Distribution of the cell cycle was analyzed by flow cytometry. Western blotting was used to indicate changes in the level of cyclins and cyclin-dependent kinases (CDKs). LBP treatment inhibited both colon cancer cell lines in a dose-dependent manner. At concentrations from 400 to 1,000 mg/l, LBP significantly inhibited the... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3168591 Tue, 12 Jan 2010 06:48:01 +0100 3168591 http://www.medworm.com/index.php?rid=3165032&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc0546407810341l7%2F In conclusion, the goal of obtaining comparable socioeconomic status by including the level of education in the matching criteria was not met in our study because of the difference in income level. The only risk reducing factor that was not in accordance with income level was the unexpectedly higher rate of bread consumption in control group. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9406-6Authors F. Icli, Ankara University School of Medicine Department of Medical Oncolocy Dikimevi 06590 Ankara TurkeyH. Akbulut, Ankara University School of Medicine Department of Medical Oncolocy Dikimevi 06590 Ankara TurkeyB. Yalcin, Ankara University School of Medicine Department of Medical Oncolocy Dikimevi 06590 Ankara TurkeyF. Ozdemir, Karadeniz Technical Universi... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3165032 Thu, 07 Jan 2010 15:59:35 +0100 3165032 http://www.medworm.com/index.php?rid=3165033&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fku6pjj2563380313%2F In conclusion, our results suggest an association of lost expression of DCC with the ovarian cancer, and DCC gene may inhibit the growth of ovarian carcinoma cells. However, this result needs further trials with a larger sample. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9400-zAuthors Liu Meimei, The Second Affiliated Hospital of Harbin Medical University Department of Obstetrics and Gynaecology 150086 Harbin Hei Longjiang ChinaLi Peiling, The Second Affiliated Hospital of Harbin Medical University Department of Obstetrics and Gynaecology 150086 Harbin Hei Longjiang ChinaLi Baoxin, Harbin Medical University College of Pharmacy 150086 Harbin Hei Longjiang ChinaLi Changmin, The Second Affiliated Hospital of Harbin Medical University Department of Obstetri... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3165033 Thu, 07 Jan 2010 15:59:34 +0100 3165033 http://www.medworm.com/index.php?rid=3165034&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk53260v487476nlm%2F Abstract  The patient was a 30-year-old-pregnant woman (para 1, gradiva 1) without in utero exposure to diethylstilbestrol. A papillary and flat lesion was found by colposcopy in the uterine cervix in the routine examination at 10 pregnancy weeks. Biopsies showed papillary and tubular proliferation of malignant cells with clear glycogen-rich cytoplasm and malignant hobnail cells and were diagnosed as clear cell adenocarcinoma. The patient was treated by radical hysterectomy. The lesion of the cervix (10 × 15 × 5 mm) was clear cell adenocarcinoma with mild invasion into shallow myometrium (pTIb). An immunohistochemical study showed that the tumor cells were positive for pancytokeratins (AE1/3, CAM5.2, KL-1, and polyclonal wide), cytokeratin (CK) 7, ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3165034 Thu, 07 Jan 2010 15:59:33 +0100 3165034 http://www.medworm.com/index.php?rid=3154313&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff548x63363u07855%2F Abstract  Because of improved therapeutic results after first-line platinum-based chemotherapy in patients with stage IV non-small-cell lung cancer (NSCLC), second-line chemotherapy may be considered for a growing number of patients. Approximately, 10% of patients have an interval time after concluding first-line platinum-based chemotherapy greater than 6 months. These patients may achieve high tumor responses when platinum is again used in second-line treatment. Twenty-three patients experiencing progression following 6 months after concluding platinum-based chemotherapy were managed with second-line treatment with carboplatin combined with gemcitabine or pemetrexed. Overall response, progression-free survival (PFS), and overall survival (OS) after initiation of secon... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3154313 Tue, 05 Jan 2010 06:51:33 +0100 3154313 http://www.medworm.com/index.php?rid=3154314&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn65j7tm0tu47875u%2F We report a case of 40-year-old female who first admitted to the hospital with symptoms and signs of weight loss, nausea and vomiting, and with findings of proteinuria renal dysfunction and anemia. Renal biopsy revealed light chain deposition and findings mimicking membranoproliferative glomerulonephritis (MPGN). Investigation of the patient for plasma cell dyscrasia was resulted in normal findings. After 28 months, she was re-evaluated and MM was diagnosed. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9404-8Authors Metin Isik, Ankara Numune Education and Research Hospital Department of Medical Oncology Sihhiye Ankara 06100 Turkey Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3154314 Tue, 05 Jan 2010 06:51:29 +0100 3154314 http://www.medworm.com/index.php?rid=3154317&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl51j713hvt43w23x%2F Abstract  The purpose of this study was to investigate the clinical signs and therapy of primary lymphoma of bone (PLB). One primary lymphoma of bone is described, and review of the pertinent literature is introduced. The patient achieved complete remission with no evidence of local recurrence. PLB are uncommon malignancies. Patients with PLB commonly present with local bone pain, soft tissue swelling and a mass or a pathological fracture. Most cases of PLB are classified as diffuse large B-cell lymphomas in the WHO classification of hematological malignancies. Comprehensive immunohistochemical studies are required to establish an accurate histological diagnosis of PLB. Early diagnosis and active treatment can improve the prognosis. Content Type Journal ArticleCategory Or... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3154317 Tue, 05 Jan 2010 06:51:28 +0100 3154317 http://www.medworm.com/index.php?rid=3154316&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5524408741405120%2F The objective of this study was to compare the efficacy and tolerability of palonosetron and granisetron in a Chinese population receiving highly emetogenic cisplatin-based chemotherapy or moderately emetogenic chemotherapy. Patients were stratified by chemotherapy with cisplatin (yes/no) and then randomly assigned to receive either palonosetron (0.25 mg i.v.) in the first cycle followed by granisetron (3 mg i.v.) in the second cycle or vice versa. The primary efficacy endpoint was the proportion of patients with complete response 0–24 h post-chemotherapy administration. The proportions of patients with complete response 24–120 and 0–120 h following chemotherapy were also compared. Of the 144 patients randomized, 36 (25%) received 60–80 mg/m2 cisplatin... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3154316 Tue, 05 Jan 2010 06:51:28 +0100 3154316 http://www.medworm.com/index.php?rid=3154315&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm561324388h28216%2F Abstract  Although several groups had conducted proteomics of nasopharyngeal carcinoma (NPC), little study was involved in phosphoproteomics, oncogenic signaling, and cancer research about NPC. Analysis of phosphotyrosine proteins from transforming growth factor alpha (TGF-a) triggered phosphotyrosine proteome permitted the identification of novel downstream substrates of the epidermal growth factor receptor (EGFR). Using functional proteomics technology based on 2-DE, 2-D western blotting, and mass spectrometry, we identified and quantified the tyrosine phosphorylation levels of 16 proteins between control and TGF-a-treated CNE2 human NPC cells. Among these proteins, tyrosine phosphorylated levels of ten proteins were increased, and those of six proteins were decreased in ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3154315 Tue, 05 Jan 2010 06:51:28 +0100 3154315 http://www.medworm.com/index.php?rid=3154318&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc12957060501x320%2F Abstract  Institutional data are conflicting regarding the prognosis of breast cancer patients with extensive (≥10) axillary lymph node (ALN) metastases. We hypothesized that overall survival (OS) and disease specific survival (DSS) improved after the introduction of anthracycline-based therapy in 1997. We used the Surveillance, Epidemiology, and End results (SEER) database to identify breast cancer patients with ≥10 ALN metastases diagnosed between 1988 and 2004. Patients were categorized according to whether they were diagnosed prior to the FDA approval of anthracyclines (pre-anthracycline era, pre-AE) or after approval (post-anthracycline era, post-AE). Univariate analyses of OS and DSS were performed using the Kaplan–Meier method and differences assessed via the l... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3154318 Tue, 05 Jan 2010 06:51:24 +0100 3154318 http://www.medworm.com/index.php?rid=3136188&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fdp78123448425071%2F Abstract  Cytokines are involved in the pathogenesis of multiple myeloma (MM) and other cancers. The aim of this study was to evaluate a range of cytokines of diverse activity in patients with multiple myeloma for a possible prognostic value. Concentrations of the following cytokines and cytokine receptors were measured by ELISA in the sera of 64 untreated MM patients: IL-6, IL-8, IL-10, TNFα, sTNF R I and II, sIL-2Rα, IL-1ra, M-CSF, G-CSF, VEGF, and bFGF. Serum levels of sTNF RI, IL-6, and bFGF were elevated in over 50% of patients. There was an inverse relationship between sTNF RII, TNFα, IL-1ra, and albumin levels. There was no significant relationship between cytokines/cytokine receptors and other serum correlates of myeloma. In a univariate survival analysis, β2-mi... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3136188 Thu, 31 Dec 2009 06:58:20 +0100 3136188 http://www.medworm.com/index.php?rid=3136189&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F44n12nk426xt0828%2F This report describes particular considerations for physicians to be aware of when choosing a treatment regimen for their elderly patients with renal cell carcinoma and offers recommendations on how to integrate specific management strategies into clinical practice that will optimize the use of sorafenib in the elderly. The strategies focus on patient selection, assessment of quality of life, management of adverse events, and appropriate dose modifications. The goal of these recommendations is to maximize the clinical benefit of sorafenib in the elderly patient population through appropriate use. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9388-4Authors Janice P. Dutcher, Montefiore Medical Center-North Division/New York Medical College Department of... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3136189 Thu, 31 Dec 2009 06:58:19 +0100 3136189 http://www.medworm.com/index.php?rid=3134344&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F661917k8104k6141%2F Abstract  Metaplastic breast carcinoma (MBC) encompasses a heterogeneous group of tumors. Based upon the microarray of MBCs, these tumors showed features of basal-like carcinoma and myoepithelial differentiation. However, MBCs entity still remained unclear. So we performed a systematic research to explicit metaplastic breast carcinomas further. A panel of ER, PR, HER-2, CK5/6, CK14, P63 and EGFR were prepared for detection of MBCs, and fluorescence in situ hybridization for HER-2 gene amplification and ultrastructure observation were also performed. Sensitiveness between CK5/6 and other antibodies in diagnosis was analysed, and survival analysis was also carried out. ER, PR and HER-2 were negative. CK5/6 (12/12), CK14 (9/12), EGFR (10/12) and P63 (8/12) were positive. FISH f... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3134344 Wed, 30 Dec 2009 06:49:07 +0100 3134344 http://www.medworm.com/index.php?rid=3134345&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw12p2r11l3383121%2F Abstract  Cisplatin (DDP)-based adjuvant chemotherapy is widely used for the treatment of esophageal cancer. However, DDP resistance has become more common and thus new approaches are required to be explored. Cisplatin was used to induce autophagy in the human esophageal cancer cell line, EC9706 cells, and the effect of autophagy on the survival of EC9706 cells was investigated using an autophagy inhibitor 3-MA. Cell viability was measured by CCK8 assay. Apoptosis and cell cycle were detected by flow cytometry. Monodansylcadaverine (MDC) was used to detect autophagy. Western blotting assay was used to investigate the molecular changes that occurred in the course of treatment. DDP inhibited cell proliferation, induced cell death and cell cycle arrest at S phage. Moreover, au... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3134345 Wed, 30 Dec 2009 06:49:05 +0100 3134345 http://www.medworm.com/index.php?rid=3134346&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd5k73h4r7l188555%2F In conclusion, FRAT1 may be an important factor in the tumorigenesis and progression of astrocytoma, which could be used as a potential biomarker for pathological diagnosis of malignancy and a target for biological therapy. Content Type Journal ArticleCategory original paperDOI 10.1007/s12032-009-9402-xAuthors Geng Guo, Fourth Military Medical University Department of Neurosurgery, Xijing Hospital 15# West Chang Le Road 710032 Xi’an Shaanxi Province People’s Republic of ChinaBolin Liu, Fourth Military Medical University Department of Neurosurgery, Xijing Hospital 15# West Chang Le Road 710032 Xi’an Shaanxi Province People’s Republic of ChinaChengliang Zhong, Fourth Military Medical University Department of Health Statistics, Faculty of Preventative Medicine 17# West Chang Le ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3134346 Wed, 30 Dec 2009 06:49:01 +0100 3134346 http://www.medworm.com/index.php?rid=3134348&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F55726r813p05p927%2F Abstract  There are no data regarding the late toxicity of trastuzumab (T) administration with radiotherapy (RT). In this experimental study, we aimed to asses if concurrent or sequential administration of T has any impact for the development of radiation-induced pulmonary fibrosis in rats. Fifty-four female Wistar-albino rats were divided into 6 groups. First group of rats (Group 1; concurrent T) had irradiation to whole thoracic region concurrently with T. Second group (Group 2: sequential T–RT) received thoracic irradiation, 1 week after T. Third group (Group 3: sequential RT–T) had thoracic irradiation first and they had T injection 1 week after RT. Fourth group (Group 4: T only) had only T application. Fifth group (Group 5: RT) had only RT. The last group... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3134348 Wed, 30 Dec 2009 06:49:00 +0100 3134348 http://www.medworm.com/index.php?rid=3134347&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv48171w221357k60%2F Abstract  Carcinogenesis of lung adenocarcinoma remains unclear and very few biomarkers have been accepted for routine clinical use. In order to explore the pathogenesis and screen ideal biomarkers, we conducted cell-map proteomics study in human lung adenocarcinoma. Homogeneous lung adenocarcinoma cells were purified by laser capture microdissection (LCM). A high performance liquid chromatography (HPLC) system was used to separate the total solution proteins. The resulting MS/MS spectra were automatically searched for proteins against IPI human protein database using the TurboSEQUEST searching engine. Physico-chemical properties of the identified proteins, including molecular weight (MW), isoelectric point (PI), were described based on various proteomics web server and sta... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3134347 Wed, 30 Dec 2009 06:49:00 +0100 3134347 http://www.medworm.com/index.php?rid=3122761&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa1p5kt1821784544%2F This article summarizes the recent advances in the treatment of newly diagnosed myeloma and suggests a treatment algorithm for approaching newly diagnosed myeloma. Content Type Journal ArticleCategory original paperDOI 10.1007/s12032-009-9370-1Authors Shaji Kumar, Mayo Clinic Rochester MN USA Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3122761 Fri, 25 Dec 2009 06:56:21 +0100 3122761 http://www.medworm.com/index.php?rid=3122762&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2408144300n472r4%2F Abstract  Pulmonary toxicity can rarely be seen with cytotoxic agents. We aimed at investigating the pulmonary toxicity of docetaxel in patients other than lung carcinoma. Forty patients were investigated prospectively. Spirometry, DLCO and high-resolution computed tomography (HRCT) scans were applied to all patients before and 14–21 days after completion of docetaxel. We used a HRCT scoring system that was based on the previous studies. We have seen no pulmonary symptoms that may reflect pulmonary toxicity. There were statistically significant differences between pre- and post-treatment values of FEV1 (L/s), FEV1/FVC (%), DLCO/VA (DLCO/L), DLCO/VA (%) (P < 0.05), FEF25–75 (L/s), FEF25–75 (%) (P < 0.01), DLCO (mL/mmHg/min), DLCO (%) (P&nb... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3122762 Fri, 25 Dec 2009 06:56:20 +0100 3122762 http://www.medworm.com/index.php?rid=3122763&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhu24h316p74835h0%2F We report a 73-year-old man with multiple myeloma presented with testicular plasmacytoma. He complained of left leg pain and scrotal swelling. Ultrasonography revealed testicular masses. Pathologic examination of the orchiectomy specimen showed plasmocytoma with kappa expression. Multiple lytic bone lesions were seen in bone survey scans, serum immunoelectrophoresis and bone marrow aspiration aided to the diagnosis of multiple myeloma. He received chemotherapy, melphalan and prednisolone, and palliative radiotherapy. He succumbed to disease after 8 months. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9390-xAuthors H. Mehmet Turk, Gaziantep University Department of Clinical Oncology, Faculty of Medicine Gaziantep 27310 TurkeySeref Komurcu, GATA Fa... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3122763 Fri, 25 Dec 2009 06:56:18 +0100 3122763 http://www.medworm.com/index.php?rid=3122764&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa80g082003884603%2F Abstract   EGF promoter polymorphisms are observed to modulate EGF levels and thought to have effect on susceptibility to various carcinomas but the results are inconsistent. In this meta-analysis, we assessed published studies of the association between three EGF polymorphisms and cancer risk from 21 studies with 14,609 subjects for EGF G61A, from two studies with 2,535 subjects for G-1380A and A-1744G, respectively. For EGF G61A, the contrast of homozygote (OR = 0.80, 95% CI = 0.65–0.98), allele (OR = 0.90, 95% CI = 0.81–0.99) and dominant model (OR = 0.86, 95% CI = 0.74–0.99) produced significant association among 21 studies with relatively large heterogeneity (P heterogeneity < 0.001). Through ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3122764 Thu, 24 Dec 2009 19:49:32 +0100 3122764 http://www.medworm.com/index.php?rid=3109020&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq6l4908l61013v14%2F Abstract  Treatment strategies for patients with stage IV endometrial cancer (EC) remain controversial. Some studies have suggested that optimal cytoreduction improves survival. We retrospectively analyzed the clinical characteristics and outcomes of 41 women with stage IV EC. The results of preoperative cytologic evaluation and biopsy of the endometrium were reviewed by a single pathologist for patients in whom stage IV EC was diagnosed preoperatively. Of the 41 patients with stage IV EC (median age, 62 years), 31 had surgical stage IV disease and 10 had clinical stage IV disease. Twenty-eight patients were diagnosed of stage IV EC before surgery or without surgery. Progression-free survival and overall survival were 10.4 and 21.3 months, respectively. On univari... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3109020 Sat, 19 Dec 2009 06:52:17 +0100 3109020 http://www.medworm.com/index.php?rid=3105974&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff6k1062777t5t338%2F Abstract  Adiponectin is a peptide hormone secreted from the adipose tissue, affecting the proliferation and insulin sensitivity in different cell types. The levels of adiponectin have been found to be decreased in hyperinsulinemia and insulin resistant states, such as obesity. The previous studies have suggested that plasma adiponectin levels are decreased in patients with endometrial and breast cancer. In our study, the relationship among serum adiponectin levels, demographic features and histopathological variables was evaluated in gastric cancer patients. Forty consecutive patients with gastric cancer who underwent gastrectomy with standard lymph node dissection were included and 43 healthy controls were included in this study. The serum levels of glucose, insulin, C-pe... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3105974 Wed, 16 Dec 2009 07:04:59 +0100 3105974 http://www.medworm.com/index.php?rid=3105976&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnv30232rq72w5054%2F Abstract  The clinical course of CLL is highly variable, and survival from the time of diagnosis of CLL can range from months to decades. Novel biological markers such as IgVH mutation, CD38, and ZAP-70 expression have shown to offer important prognostic informations. Few reports deal with the sCD138 levels and bad prognostic factors in patients with CLL, and contrasting data are reported in literature. In our study, we evaluated the serum level of sCD138 in patients with B-CLL and its relationship with other prognostic markers. There was a significant association between advanced Rai stage and serum sCD138 levels in CLL subjects. Patients with Rai stage III-IV had significantly higher levels of sCD138 with respect to controls (48.85 ± 34 ng/ml vs. 31.1 ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3105976 Wed, 16 Dec 2009 07:04:58 +0100 3105976 http://www.medworm.com/index.php?rid=3105975&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxn16u53630r058k7%2F This study was carried out to find whether propolis preparations and related flavonoids (quercetin, naringin) might enhance irinotecan-induced cytotoxicity to tumor cells in mice bearing Ehrlich ascites tumors (EAT) while protecting normal blood, liver, and kidney cells. The preparation of propolis and their flavonoids were given to mice intraperitoneally at a dose of 100 mg kg−1 body weight for three consecutive days before the ip injection of EAT cells (2 × 106). Irinotecan was administered ip at dose of 50 mg kg−1 on days 3, 4, and 5 after tumor cell inoculation. The combination treatment resulted in substantial inhibition of the growth of EAT cells as well as treatment with quercetin or irinotecan alone, whereas other treatment by itself showed li... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3105975 Wed, 16 Dec 2009 07:04:58 +0100 3105975 http://www.medworm.com/index.php?rid=3097735&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgn1lx776uq317r61%2F Abstract  A mimic of phosphorylated prolactin (S179D PRL) inhibits mouse normal mammary HC11 cell proliferation through the upregulation of the vitamin D receptor (VDR) and p21. Here, we investigated whether S179D PRL also inhibited growth of human breast cancer MCF7 cells via VDR and p21. Western blots showed that S179D PRL upregulated VDR and p21 after the cells were incubated with S179D PRL for 3 days. These effects were blocked by the MAP kinase blocker PD98059 (25 μM), indicating that MAPK plays a role in VDR and p21 upregulation. To confirm whether VDR contributes to p21 upregulation, we used two constructs that express luciferase. One (p21 VDRE Luc) has the vitamin D response element (VDRE) in the p21 promoter region; the other (p21 NO-VDRE Luc) does not. ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3097735 Tue, 15 Dec 2009 07:12:39 +0100 3097735 http://www.medworm.com/index.php?rid=3085903&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc83x12l202202185%2F This study included 100 patients diagnosed with bladder cancer, 93 patients with benign urological disorders and 47 healthy volunteers. The urine supernatant was used for determination of fibronectin by ELISA, while urine sediment was used for cytology and detection of mutant p53 by PCR-SSCP followed by DNA sequencing. The sensitivity and specificity were 59% and 91.4% for VUC, 82% and 84.3% for fibronectin, and 37% and 100% for mutant p53; combination of the three parameters increased sensitivity to 95% but specificity was only 78.6%. A significant association was observed between disease recurrence and mutant p53, stage and lymph node involvement. Our results indicate that fibronectin had the highest sensitivity compared to VUC and mutant p53 in bladder cancer detection; however, m... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3085903 Fri, 11 Dec 2009 06:54:54 +0100 3085903 http://www.medworm.com/index.php?rid=3085905&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb056w325575t1816%2F Abstract  The role of immunomodulatory-based therapy with thalidomide or lenalidomide is clearly established in the management of patients with myeloma in all phases of their disease. Recent preclinical and clinical works have demonstrated that in addition to combination therapy with dexamethasone, there is significant activity when combined with the proteasome inhibitor bortezomib. More recent clinical studies have also demonstrated significant activity when combined with akt inhibitors, HDAC inhibitors, and even monoclonal antibodies. Further clinical development of immunomodulatory agents should continue to be based on preclinical rationale, which has resulted in a number of promising and clinically active combinations. Content Type Journal ArticleCategory Original Pap... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3085905 Fri, 11 Dec 2009 06:54:53 +0100 3085905 http://www.medworm.com/index.php?rid=3085904&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk5225545074h6276%2F In this study, we detected the expression of Notch1 in ovarian tissues and human ovarian cancer cell lines. We also analyzed the expression of Notch1 and its relationship with differentiation status and FIGO (Federation International of Gynecology and Obstetrics) stage in ovarian cancer tissues. Immunohistochemistry, real-time polymerase chain reaction and Western blot were used to detect the expression of Notch1 in 109 ovarian cancer tissues, 65 patient-matched opposite side normal ovarian tissues and 48 normal ovarian tissues, together with A2780, HO-8910 and IOSE 144 cell lines. Our results showed that the expression of Notch1 in ovarian cancer tissues was higher than that in matched normal tissues and normal tissues, Notch1 is highly expressed in ovarian cancer cells A2780 and HO... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3085904 Fri, 11 Dec 2009 06:54:53 +0100 3085904 http://www.medworm.com/index.php?rid=3085907&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl54634n233363237%2F In conclusion, sorcin might play an important role in the resistibility to gemcitabine, and it could also be a novel candidate biomarker for predicting the response of NSCLC patients to gemcitabine treatment. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9379-5Authors Yiqing Qu, Shandong University Department of Respiratory Medicine, Qilu Hospital 250012 Jinan ChinaYie Yang, Shandong Provincial Qianfoshan Hospital Clinical Laboratory 250014 Jinan ChinaBaoyi Liu, Shandong University Department of Respiratory Medicine, Qilu Hospital 250012 Jinan ChinaWei Xiao, Shandong University Department of Respiratory Medicine, Qilu Hospital 250012 Jinan China Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3085907 Thu, 10 Dec 2009 15:24:29 +0100 3085907 http://www.medworm.com/index.php?rid=3085906&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc5271555v5027g60%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s12032-009-9378-6Authors Erkan Dogan, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara TurkeySercan Aksoy, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara TurkeyCagatay Arslan, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara TurkeyDidem S. Dede, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara TurkeyKadri Altundag, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara Turkey Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3085906 Thu, 10 Dec 2009 15:24:29 +0100 3085906 http://www.medworm.com/index.php?rid=3085908&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F425638134g217271%2F Abstract  Transforming growth factor β (TGF-β) is a cytokine. The TGF-β signaling pathway plays an important role in controlling cell proliferation and differentiation involved in colorectal carcinogenesis. In mammalian cells, TGFB1 is the most abundant subtype of TGF-β. The 509 C/T polymorphism in TGFB1 has been implicated in colorectal cancer risk. However, published data remain conflicting. To derive a more precise estimation of the relationship, a meta-analysis of 994 cases and 2,335 controls from five published case–control studies was performed. Overall, significantly increased colorectal cancer risks were found for CC versus TT (OR = 1.62; 95% CI: 1.30–2.02; P heterogeneity = 0.118), TC + CC versus TT (OR = 1.30; 95% CI... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3085908 Thu, 10 Dec 2009 15:24:28 +0100 3085908 http://www.medworm.com/index.php?rid=3080366&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd82828904p73m592%2F Abstract  Primary hepatic leiomyosarcoma (PHL), a malignant mesenchymal tumor of myogenic origin, is exceedingly rare. Patients may be afflicted with a wide spectrum of nonspecific symptoms, and most of the laboratory data are unhelpful to diagnosis. Here, we report a 44-year-old woman with anorexia and right upper quadrant pain who was diagnosed as having malignant hepatic tumor within the Milan criteria and treated by orthotopic liver transplantation (OLT), the pathologic diagnosis of PHL was made by postoperative immunohistochemical study. She underwent six courses of intravenous chemotherapy and enjoyed a 14-month tumor recurrence-free survival until the lymph node metastasis was detected, then we switched the tacrolimus to sirolimus and the patient survived for 20&nbsp... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3080366 Wed, 09 Dec 2009 06:51:15 +0100 3080366 http://www.medworm.com/index.php?rid=3064181&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq7g6877033l8w07x%2F We describe a large outbreak of CVCs-associated Klebsiella oxytoca bloodstream infection, occurring in an oncology chemotherapy outpatient unit of northern Greece between October 2006 and May 2007. The outbreak involved approximately 10% of the patients with CVCs who were receiving home-based chemotherapy, and it represents the second larger outbreak of CVCs-associated BSIs due to Klebsiella oxytoca in oncology outpatient centers. We retrospectively analyzed the chain of investigations and prophylactic/diagnostic measures taken to eradicate the infection: (1) patients’ chart audit, (2) estimation of the infection among asymptomatic patients, (3) implementation of the level of awareness of medical and paramedical personnel, (4) collection of samples from environment, medications and... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3064181 Sat, 05 Dec 2009 09:00:00 +0100 3064181 http://www.medworm.com/index.php?rid=3064183&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F82221l5tm65522n6%2F Abstract  This pilot study was undertaken to assess the effect of weekly docetaxel, cisplatin and fluorouracil (DCF) as a preoperative treatment for gastric cancer with multiple synchronous hepatic metastases. Gastric cancer patients with synchronous multiple liver metastasis were first given preoperative chemotherapy consisting of two courses (each course consisted of 6-week administration and 2-week withdrawal) of weekly DCF regimen. Following the operation, postoperative chemotherapy and hepatic arterial infusion (HAI) treatment were performed as required. Eight patients completed two courses of preoperative chemotherapy with weekly DCF regimen. No toxicity of grade 3 or more was observed during the course of chemotherapy. The response rate was 100% according to the RECI... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3064183 Sat, 05 Dec 2009 08:59:59 +0100 3064183 http://www.medworm.com/index.php?rid=3064182&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg382537824276613%2F Abstract  To study the expression of the Krüppel-like transcription factor 6 (KLF6) in human gastric carcinoma and normal gastric mucosa tissues, and to explore the role of KLF6 in the carcinogenesis and tumor progression and its clinical significance. Expression of KLF6, P21WAF1 and PCNA was investigated by immunohistochemistry for 69 surgically resected gastric carcinoma tissues and corresponding normal gastric mucosa tissues, respectively. The correlations of KLF6 expression with clinicopathological characteristics, P21WAF1 and PCNA were examined. Positive-expression of KLF6 was 64 out of 69 cases (92.8%) in normal gastric mucosa and only 23 cases (33.3%) in gastric carcinoma. Expression of KLF6 in the gastric carcinoma was remarkably lower than normal gastric mucosa. D... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3064182 Sat, 05 Dec 2009 08:59:59 +0100 3064182 http://www.medworm.com/index.php?rid=3064184&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx51547612844g142%2F Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9371-0Authors Giuseppe Procopio, Fondazione Istituto Nazionale dei Tumori Medical Oncology, Unit 2 Milan ItalyElena Verzoni, Fondazione Istituto Nazionale dei Tumori Medical Oncology, Unit 2 Milan ItalyEmilio Bajetta, Fondazione Istituto Nazionale dei Tumori Medical Oncology, Unit 2 Milan Italy Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3064184 Wed, 02 Dec 2009 08:39:50 +0100 3064184 http://www.medworm.com/index.php?rid=3064185&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm182822976271v74%2F We examined the expression of the Bmi1 in colon cancer and its relevance to other characteristics, especially the 5-year survival of colon cancer. The expression of Bmi1 was examined in colorectal carcinoma (n = 98) by using real-time polymerase chain reaction. Expression was correlated with clinicopathologic variables, 5-year overall survival (OS) rates. We for the first time found that high expression of Bmi1 was significantly associated with poor survival. Fourfold Table Chi-square Test analysis revealed that Bmi1 expression was closely related to TNM stage and histologic grade, while not relevant to age. In summary, the high expression of polycomb-group protein Bmi1 is an essential and important predictor of colorectal cancer prognosis. Content Type Journal ArticleCat... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3064185 Tue, 01 Dec 2009 21:05:17 +0100 3064185 http://www.medworm.com/index.php?rid=3053750&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F332614151g512q4j%2F Abstract  Due to the ineffective conventional treatment for hepatocellular carcinoma (HCC), the nonviral gene delivery system has been proved to be an attractive alternative to HCC therapy. In this work, we have developed a kind of new self-assembled nanoparticles, which were named as amino-modified silica nanoparticles (AMSNs). Scanning electron microscopy and zeta potential results demonstrated that AMSNs had a diameter of 20–30 nm and positive surface charges of +11.3 mV, respectively. The AMSNs could bind DNA strongly and protect DNA from degradation, which was confirmed by DNA-binding assay and serum protection assay. Furthermore, AMSNs could transfer foreign DNA into targeted cells with high transfection efficiency and little cytotoxicity. Combined with the... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3053750 Tue, 01 Dec 2009 08:43:38 +0100 3053750 http://www.medworm.com/index.php?rid=3053751&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F285831v2k15u7j47%2F This study investigated the effect of MMR status on the treatment outcomes for CAPOX and FOLFOX as first-line combination chemotherapy in recurrent or metastatic colon cancer. We analyzed 171 patients who had been treated with CAPOX or FOLFOX as first-line combination chemotherapy in recurrent or metastatic colon adenocarcinoma between February 2004 and July 2008. Tumor expression of the MMR proteins, MLH1 and MSH2, was detected by immunohistochemistry (IHC) in surgically resected tumor specimens. The microsatellite instability (MSI) was analyzed by polymerase chain reaction (PCR) amplification, using fluorescent dye-labeled primers specific to microsatellite loci. Tumors with MMR defect were defined as those demonstrating a loss of MMR protein expression (MMR-D) and/or a microsatell... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3053751 Tue, 01 Dec 2009 08:43:36 +0100 3053751 http://www.medworm.com/index.php?rid=3097736&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9330475267455726%2F Abstract  Colorectal cancer is one of the most common cancers. Survivin is strongly immunogenic in a fraction of colorectal cancer patients. The present study was designed to determine whether full-length mouse Survivin dominant-negative mutant SurvivinT34A has the antitumor activity in a murine colon carcinoma model. The complex of cationic liposome (DOTAP/Chol) to plasmid pORF9—mSurvivin T34A was administered intravenously in a mouse subcutaneous (S. C.) CT 26 tumor model. Apoptotic cells and anti-angiogenesis were evaluated by fluorescent in situ TUNEL assay and by immunohistochemistry with an antibody reactive to CD31, respectively. A 4 h 51Cr release assay was performed to determine Survivin-specific cytotoxicity. The adoptive transfer of CD8+ or CD4+ T-lymphocyt... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3097736 Tue, 01 Dec 2009 08:43:34 +0100 3097736 http://www.medworm.com/index.php?rid=3053753&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq028p41452571p71%2F In conclusion, recurrence should be treated with multimodalities. Our experience of long-term survivors after treatment of recurrence is encouraging. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9369-7Authors Patricia Tai, University of Saskatchewan Department of Radiation Oncology, Allan Blair Cancer Center 4101 Dewdney Avenue Regina SK S4T 7T1 CanadaEdward Yu, University of Western Ontario London ON CanadaAvi Assouline, Centre hospitalier Universitaire d’Amiens Amiens FranceJi Dong Lian, Windsor Cancer Center Windsor ON CanadaKurian Joseph, University of Alberta Cross Cancer Institute Edmonton AB CanadaThomas Miale, University of Saskatchewan Department of Radiation Oncology, Allan Blair Cancer Center 4101 Dewdney Avenue Regina SK S4T 7T1 CanadaClaude... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3053753 Tue, 01 Dec 2009 08:43:34 +0100 3053753 http://www.medworm.com/index.php?rid=3053752&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9330475267455726%2F Abstract  Colorectal cancer is one of the most common cancers. Survivin is strongly immunogenic in a fraction of colorectal cancer patients. The present study was designed to determine whether full-length mouse Survivin dominant-negative mutant SurvivinT34A has the antitumor activity in a murine colon carcinoma model. The complex of cationic liposome (DOTAP/Chol) to plasmid pORF9—mSurvivin T34A was administered intravenously in a mouse subcutaneous (S. C.) CT 26 tumor model. Apoptotic cells and anti-angiogenesis were evaluated by fluorescent in situ TUNEL assay and by immunohistochemistry with an antibody reactive to CD31, respectively. A 4 h 51Cr release assay was performed to determine Survivin-specific cytotoxicity. The adoptive transfer of CD8+ or CD4+ T-lymphocyt... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3053752 Tue, 01 Dec 2009 08:43:34 +0100 3053752 http://www.medworm.com/index.php?rid=3053754&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F87107053m0571gj7%2F We examined the expression of HBx gene after RNA interference by semi-quantitative RT-PCR and assessed the effect of HBx knocked down on cell growth by proliferation assay using kit-8 (CCK8). As well as, we analyzed cell cycle distribution by flowcytometry and examined cell apoptosis using TUNEL assay. The HBx mRNA expression level is reduced, and cells growth was significantly stopped in 21543 cell lines. Cells with HBx knockdown were more sensitive to 5-fluorouracil/cisplatin. RNA interfering HBx induced an obvious time and dose-dependent inhibitory in comparison with the control cells. Meanwhile, RNA interferenced targeting HBx, in combination with chemotherapy can effectively induce apoptosis in hepatocellular carcinoma cells and restricts cell proliferation. Content Type Jou... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3053754 Tue, 01 Dec 2009 08:43:33 +0100 3053754 http://www.medworm.com/index.php?rid=3040819&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm185274512t40464%2F In conclusion, hyperleukocytosis confers a poorer prognosis in patients with AML. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9367-9Authors L. C. O. Oliveira, University of Sao Paulo Medical School of Ribeirao Preto Rua Tenente Catão Roxo, 2501 Ribeirão Preto SP 14051-140 BrazilL. G. M. Romano, University of Sao Paulo Medical School of Ribeirao Preto Rua Tenente Catão Roxo, 2501 Ribeirão Preto SP 14051-140 BrazilB. P. A. Prado-Junior, University of Sao Paulo Blood Center of Ribeirao Preto Ribeirao Preto BrazilD. T. Covas, University of Sao Paulo Medical School of Ribeirao Preto Rua Tenente Catão Roxo, 2501 Ribeirão Preto SP 14051-140 BrazilE. M. Rego, University of Sao Paulo Medical School of Ribeirao Preto Rua Tenente Catão Roxo, 2501 Ribeirão Pr... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3040819 Wed, 25 Nov 2009 17:03:38 +0100 3040819 http://www.medworm.com/index.php?rid=3031678&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F17j40521w9314tr2%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s12032-009-9368-8Authors Erkan Dogan, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara TurkeySercan Aksoy, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara TurkeyOmer Dizdar, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara TurkeyDidem S. Dede, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara TurkeyCagatay Arslan, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara TurkeyYavuz Ozisik, Hacettepe University Institute of Oncology Department of Medical Oncology Sihhiye 06100 Ankara TurkeyKadri Altun... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3031678 Tue, 24 Nov 2009 07:16:14 +0100 3031678 http://www.medworm.com/index.php?rid=3031680&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F02w34567258l2127%2F This study included 51 patients with EOC, 27 patients with benign ovarian lesions and 29 healthy volunteers. Serum CA 125 was determined by microparticle enzyme immunoassay, while serum MMP-7, CCL18 and CCL11 were measured using enzyme-linked immunosorbent assay. The sensitivity and specificity were 86.3% and 92.9% for CA 125, 80.4% and 87.5% for MMP-7, 84.3% and 91.1% for CCL18 and, 68.6% and 62.5% for CCL11. Combination of CA 125, MMP-7, CCL18 and CCL11 gave a promising sensitivity of 100%, but specificity was decreased to 60.7%. The combined use of serum CA 125, MMP-7, CCL18 and CCL11 effectively detected early stages EOC with high sensitivity of 94.4%. Our data indicate that serum MMP-7, CCL18 and CCL11, in combination with CA 125 could be useful in diagnosis of EOC. Content T... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3031680 Tue, 24 Nov 2009 07:16:13 +0100 3031680 http://www.medworm.com/index.php?rid=3031679&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F03428l35333h4w42%2F Abstract  Castleman’s disease (CD) is a rare disorder characterized by non-cancerous tumor growth that may develop in the lymph node tissue at a single site or throughout the body (Castleman et al. in Cancer 9:822–830, 1956). It involves hyperproliferation of specific B cells that produce the cytokine IL-6. This disorder is often undiagnosed or misdiagnosed. For this reason, only very few patients have been reported, and little information is available in the literature. In hopes of providing a better understanding of this rare disease, this report examines 52 patients with Unicentric Castleman’s disease (UCD) and Multicentric Castleman’s disease (MCD) treated from 1999–2008 at a single institution. Fifty-two patients with CD, along with their histological diagnos... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3031679 Tue, 24 Nov 2009 07:16:13 +0100 3031679 http://www.medworm.com/index.php?rid=3031681&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff32308527242665n%2F This study evaluates the inhibition of in vitro propagating LNCaP cells employing mono- and bispecific oligos directed against bcl-2 [the second bispecific binding site was directed against the epidermal growth factor receptor (EGFR)]. Employing RT-PCR, the expression of non-targeted proteins encoded by mRNA for prostate-specific membrane antigen (PSMA) and prostate-specific antigen (PSA) were subsequently evaluated. When LNCaP prostate tumor cells were incubated with bispecific oligos (directed against bcl-2 and EGFR) and compared to lipofectin-containing controls significant growth inhibition resulted. In subsequent experiments, the levels of mRNA encoding PSMA were unexpectedly found to be elevated following treatment with the bispecific oligos but not with the monospecific direct... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3031681 Tue, 24 Nov 2009 07:16:12 +0100 3031681 http://www.medworm.com/index.php?rid=3019979&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkq1220077gr46135%2F This study investigated for the first time the correlation between the mTOR/p70S6K signal transduction pathway in human osteosarcoma and patients’ prognosis. The expression patterns of mTOR and p70S6K in paraffin-embedded specimens gathered from 65 patients with primary osteosarcoma were detected by the method of immunohistochemistry using antibodies against mTOR and p70S6K. Kaplan–Meier survival and Cox regression analyses were performed to evaluate the prognosis of patients. Immunostaining revealed that the mTOR/p70S6K signal transduction pathway is activated in human osteosarcoma. Additionally, positive expression of mTOR and p70S6K proteins was significantly correlated with surgical stage, metastasis pattern and percentage of dead cells of osteosarcoma. Moreover, in univaria... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3019979 Sat, 21 Nov 2009 08:56:20 +0100 3019979 http://www.medworm.com/index.php?rid=3016045&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F38w15112832t2128%2F Abstract  In this retrospective study, we investigated the incidence of esophagorespiratory fistula (ERF) in esophageal squamous cell carcinomas, clinical characteristics and outcomes of esophageal cancer patient with ERF, and effective therapeutic options. From 1998 to 2007, 1,095 patients with squamous cell carcinomas of the esophagus were treated at Samsung Medical Center. A comprehensive retrospective review of all these patients with clinical data of ERF was performed. The incidence of ERF in patients with esophageal cancer was 4.7% (52/1095). Comparing with the patients without ERF, the patients with ERF presented with a more advanced stage of disease, more frequent involvement of upper-mid thoracic esophagus, a longer segment of the tumor, and more initial airway inv... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3016045 Thu, 19 Nov 2009 07:25:46 +0100 3016045 http://www.medworm.com/index.php?rid=3016046&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2235888r497v8932%2F In this study, we first analyze the role of HDGF in colorectal carcinoma (CRC) progression by immunohistochemistry. Then we used small interference RNA (HDGF-siRNA) to block HDGF and assessed its effect on inducing apoptosis of CRC loVo cells. Apoptosis was detected using flow cytometry (FCM), DNA ladder analysis, and Hoechst 33258 staining. In addition, the expression levels of some apoptosis-related proteins were examined by western blot. The result showed that HDGF expression gradually increased in the colorectal carcinogenesis process. Further studies demonstrated that knock-down of HDGF can down-regulate the survivin, activate the mitochondrial pathway, and induce apoptosis in loVo cells. These findings suggest that HDGF is involved in colorectal carcinogenesis process. Further ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3016046 Thu, 19 Nov 2009 07:25:44 +0100 3016046 http://www.medworm.com/index.php?rid=3016047&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh560q1612n38mw76%2F In conclusion, serum BMP-2 is associated with progression from early localized gastric cancer to locally advanced gastric cancer. Content Type Journal ArticleCategory Original paperDOI 10.1007/s12032-009-9358-xAuthors Yong Park, Korea University Division of Hematology/Oncology, Department of Internal Medicine, College of Medicine Guro Hospital, 80 Guro-Dong, Guro-Gu Seoul 152-703 KoreaMyoung Hee Kang, Korea University Graduate School of Medicine Seoul KoreaHee Yeon Seo, Korea University Division of Hematology/Oncology, Department of Internal Medicine, College of Medicine Guro Hospital, 80 Guro-Dong, Guro-Gu Seoul 152-703 KoreaJoong Min Park, Chung-Ang University Department of Surgery, College of Medicine Seoul KoreaChul Won Choi, Korea University Division of Hematology/Oncology, Depa... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3016047 Thu, 19 Nov 2009 07:25:43 +0100 3016047 http://www.medworm.com/index.php?rid=3009610&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F321x4155hx427m53%2F Abstract  A 73-year-old female with malignant melanoma metastatic to her left frontal lobe status post-gross total resection of the metastasis, whole brain radiotherapy, and Gamma Knife-based stereotactic radiosurgery for local recurrence presented with an area of increasing enhancement on follow-up magnetic resonance imaging (MRI) and hypermetabolic lesions on 18-fluorodeoxyglucose positron emission tomography/computerized tomography (18FDG PET/CT) of the brain suspicious for tumor recurrence. Surgical resection of the lesion was performed showing radiation necrosis with no evidence of tumor. The patient was alive 1 year after her second craniotomy. This case illustrates that despite being perceived as a radioresistant histology, complete local eradication of melanoma ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3009610 Wed, 18 Nov 2009 09:36:34 +0100 3009610 http://www.medworm.com/index.php?rid=3009612&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn643g4r2k211831x%2F Abstract  The aim of the study was to investigate whether the presence of matrix metalloproteinase-2 (MMP-2) and its inducer, extracellular matrix metalloproteinase inducer (EMMPRIN), in primary cutaneous malignant melanoma (PCMM) might help to predict patient prognosis. Immunohistochemical staining was performed on formalin-fixed, paraffin-embedded sections of PCMM from 150 patients. Association of clinical variables (gender, age, tumor location, thickness, Clark level and AJCC stage) with EMMPRIN and MMP-2 expression were analyzed by Fisher’s exact test. Survival rates were subsequently estimated using the Kaplan–Meier method and compared using the log-rank test. The expression of EMMPRIN and MMP-2 was detected in 117/150 (78.0%) and 115/150 (76.7%) of patients with P... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3009612 Wed, 18 Nov 2009 03:47:33 +0100 3009612 http://www.medworm.com/index.php?rid=3009611&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn506633g752w57n2%2F Abstract  Antiapoptosis and invasion are the causes for the failure of conventional radiotherapy and chemotherapy in human renal carcinomas. Osteopontin (OPN), a ligand for vß3 integrin and CD44 receptors, is a phosphorylated glycoprotein with diverse functions including tumorigenesis and tumor cell metastasis. Recently, OPN has been detected in human renal carcinomas and assessed as a potential prognostic marker of renal carcinomas. However, the function and mechanism of OPN in renal carcinomas remain unknown. In this study, we used OPN siRNA to silence the expression of OPN in renal carcinoma Caki-1 cells. Silent effect showed that sequence-specific siRNA targeting OPN suppressed OPN mRNA expression by 81% and OPN protein level by 91% in vitro. The apoptosis ability was ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=3009611 Wed, 18 Nov 2009 03:47:33 +0100 3009611 http://www.medworm.com/index.php?rid=2990290&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F75l45n5x733j11l2%2F This study aimed to find out the expression features of VEGF and Cx43 and their significance in pancreatic cancer. The expression levels of VEGF and Cx43 protein in the samples, which came from 100 patients of human pancreatic cancer tissues and adjacent normal pancreatic tissues, were examined by using immunohistochemical streptavidin–peroxidase (S–P) method, Western-blotting, and RT–PCR analyses. Compared with adjacent normal pancreatic tissues, RT–PCR showed that the expression of VEGF mRNA was significantly higher in pancreatic cancer tissues (0.788 ± 0.290, P < 0.01) and Cx43 mRNA was significantly lower in pancreatic cancer tissues (0.403 ± 0.204, P < 0.01). The expression of VEGF protein was higher in pancreatic cancer tiss... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2990290 Thu, 12 Nov 2009 09:10:14 +0100 2990290 http://www.medworm.com/index.php?rid=2990291&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn0x44262570742k4%2F Abstract  The medicinal properties of curcumin are well documented in Indian and Chinese systems of medicine, which refer to its wide use in the treatment of some diseases. It has shown to have anti-carcinogenic properties and is known to prevent tumor development in some cancers. In our study, we confirmed that the expression of miR-15a and miR-16 was upregulated and that of Bcl-2 was downregulated in curcumin-treated MCF-7 cells. Silencing miR-15a and miR-16 by specific inhibitors restored the expression of Bcl-2. Thus, we concluded that curcumin can reduce the expression of Bcl-2 by upregulating the expression of miR-15a and miR-16 in MCF-7 cells. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9344-3Authors Jie Yang, Tangdu Hospital Departm... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2990291 Thu, 12 Nov 2009 09:10:03 +0100 2990291 http://www.medworm.com/index.php?rid=2990292&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6272654k1617850p%2F Abstract  The aims of this study were to reveal the correlation between the transcription factor CDX2 and proinflammatory cytokines interleukin-1beta, tumor necrosis factor-alpha in the gastric cancerous tissues and gastric cancer cell line. Expression of CDX2 and proinflammatory cytokines in the gastric cancer tissues was analyzed by immunohistochemistry, immunoblotting and ELISA. The effect of interleukin-1beta and tumor necrosis factor-alpha on CDX2 messenger RNA, protein and promoter activity was analyzed in gastric cancer cell line AGS using real-time PCR, immunoblotting and EMSA. In the gastric cancerous tissues, CDX2 expression was found to exhibit an inverse correlation with the levels of interleukin-1beta (P = 0.040) and tumor necrosis factor-alpha (P&nbsp... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2990292 Thu, 12 Nov 2009 09:09:52 +0100 2990292 http://www.medworm.com/index.php?rid=2986144&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6160wh53517007j5%2F This study investigates the clinical, pathologic and prognostic characteristics of gastroenteropancreatic neuroendocrine tumors that presented to the Medical Oncology Outpatient Clinic, İstanbul University, Cerrahpaşa School of Medicine from 1995 to 2006 (n = 86). The mean age of the patients was 52 ± 14 and the male-to-female ratio was 0.87. The most common site of involvement was the stomach. Midgut intestinal tumors seemed to have significant female predominance compared to hindgut intestinal tumors (P = 0.016). Most of the patients had metastatic disease with a prevalence of 34.9%. Poorly differentiated tumors and mixed neuroendocrine carcinomas were significantly larger than 2 cm (P = 0.0001). The median survival was 139 months... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2986144 Wed, 11 Nov 2009 19:12:11 +0100 2986144 http://www.medworm.com/index.php?rid=2982436&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7164r13w6561076j%2F Abstract  Gemcitabine (2′,2′-difluoro 2′deoxycytidine, dFdC) is an analog of cytosine with distinctive pharmacological properties and a wide antitumor-activity spectrum. The pharmacological characteristics of gemcitabine are unique because two main classes of genes are essential for its antitumor effects: membrane transporter protein-coding genes, whose products are responsible for drug intracellular uptake, as well as enzyme-coding genes, which catalyze its activation and inactivation. The study of the pharmacogenetics and pharmacoepigenetics of these two gene classes is greatly required to optimize the drug’s therapeutic use in cancer. This review aims to provide an update of genetic and epigenetic bases that may account for interindividual variation in therapeuti... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2982436 Tue, 10 Nov 2009 07:52:53 +0100 2982436 http://www.medworm.com/index.php?rid=2974771&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw321213800n6wt83%2F Abstract  Large-cell neuroendocrine carcinoma is a high-grade neuroendocrine carcinoma, originally described in the lung. The tumor rarely occurs in extrapulmonary sites like the gastrointestinal tract, and only few examples have been described in the ampulla of Vater. A new case of large-cell neuroendocrine carcinoma of the ampulla of Vater in a 60-year-old man is reported. After pancreatoduodenectomy, macroscopic examination revealed ulcerated tumor in the region of the ampulla of Vater. Microscopically, the tumor exhibited organoid, predominantly nested growth pattern, consisting of large, polygonal cells with pleomorphic nuclei. Average number of mitoses was 36 per 10 high-power fields. Small and large areas of necrosis were identified. Immunohistochemically, the tumor ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2974771 Sat, 07 Nov 2009 07:37:05 +0100 2974771 http://www.medworm.com/index.php?rid=2974772&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd11u01711116x052%2F Abstract  Adenocarcinoma arising from the ampulla of Vater is a rare neoplasm that accounts for only 0.2% of all gastrointestinal tract malignancies and has limited data regarding its frontline therapy. We investigated the treatment outcomes in patients with advanced adenocarcinoma of the ampulla of Vater receiving frontline cisplatin-based combination chemotherapy. We analyzed 29 patients with advanced adenocarcinoma of the ampulla of Vater who had been treated by frontline cisplatin-based combination chemotherapy between June 2003 and April 2008. The chemotherapeutic agent added to cisplatin was gemcitabine in 9 patients and fluorouracil (FU) in 20 patients (11; intravenous 5-FU and 9; oral 5-FU (capecitabine)). The median age of patients was 56 years (range, 36–78... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2974772 Sat, 07 Nov 2009 07:37:03 +0100 2974772 http://www.medworm.com/index.php?rid=2968547&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj831742724q672w5%2F We report two cases of stage IV malignant melanoma arising in patients treated with azathioprine for myasthenia gravis. In both cases, the melanoma metastases regressed upon withdrawal of immunosuppression. One patient remains melanoma free at 10 years, and the second patient experienced an 18-month disease free period. There is one prior case report in the medical literature to support full immune reconstitution for treatment in advanced immunosuppression-related melanoma, and one case series suggesting that transplant patients developing melanoma may benefit from a switch to sirolimus. Virtually, no data exist for the medical management of early stage melanoma in the immunosuppressed patients. We review the limited preclinical data in support of immune reconstitution and the d... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2968547 Thu, 05 Nov 2009 07:46:28 +0100 2968547 http://www.medworm.com/index.php?rid=2960349&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F087j74340r62t5x5%2F Abstract  The aim of this paper was to identify novel proteins involved in the development of gastric cancer (GC). Isobaric tags for relative and absolute quantification (iTRAQ) analysis was adopted to separate the differentially expressed proteins between normal gastric epithelial cell line GES-1 and GC cell line SGC7901. Western blotting was utilized to validate the increased expression of sorcin in SGC7901; immunohistochemistry was performed to investigate its relationship with clinicopathological features of GC. Twelve differential proteins were identified. Seven proteins were found to be significantly upregulated (≥twofold), while five proteins were markedly downregulated (≤0.5-fold), in SGC7901 cells. Sorcin was detected by this proteomic approach with a 5.4-fold ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2960349 Tue, 03 Nov 2009 14:16:38 +0100 2960349 http://www.medworm.com/index.php?rid=2960351&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff7503q682p656m2g%2F Abstract  The aim of this study was to evaluate the efficacy and toxicity of docetaxel (TAX), cisplatin (CDDP), and fluorouracil (5-FU) plus leucovorin (CF) as the neoadjuvant chemotherapy (NACT) regimens in the treatment of nonresectable advanced gastric cancer. Twelve patients with nonresectable advanced gastric cancer were treated with NACT regimens consisted of docetaxel, cisplatin, fluorouracil, plus leucovorin before operation. Nine of the 12 patients were downstaged and 8 were radically operated after the end of the NACT. The overall response rate was 75% with 8.3% complete response and 66.7% partial response, and the ascites disappeared in 63.6%. The most common toxicities were bone marrow suppression, nausea, vomiting, alopecia, and heptoses. The toxicities were re... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2960351 Tue, 03 Nov 2009 14:16:36 +0100 2960351 http://www.medworm.com/index.php?rid=2960350&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F74424r6j912408km%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s12032-009-9346-1Authors Didem S. Dede, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeySercan Aksoy, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeyOmer Dizdar, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeyPamir Cerci, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeyIbrahim Gullu, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeyYavuz Ozisik, Hacettepe University Institute of Oncology Department of Medical Oncology Sıhhiye 06100 Ankara TurkeyKadri ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2960350 Tue, 03 Nov 2009 14:16:36 +0100 2960350 http://www.medworm.com/index.php?rid=2960353&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F630735n25705706j%2F Abstract  Presence of the Philadelphia chromosome in acute lymphoblastic leukemia is the single most adverse prognostic marker associated with high risk of disease relapse and poor prognosis. Allogeneic haematopoietic stem cell transplantation is considered as the only curative option in adults with Philadelphia-positive acute lymphoblastic leukemia, but relapse remains the main cause of treatment failure. Moreover, long-term survival rates are markedly decreased when transplanted patients are not in complete remission. Incorporation of tyrosine kinase inhibitors into transplantation strategy in patients with Philadelphia-positive acute lymphoblastic leukemia may improve prognosis of the disease. Imatinib combined with conventional chemotherapy and used in conjunction with ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2960353 Tue, 03 Nov 2009 14:16:35 +0100 2960353 http://www.medworm.com/index.php?rid=2960352&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6h6464u46pu52634%2F Abstract  The purpose of this study was to determine outcome of the ratio of metastatic lymph nodes to the total number of dissected lymph nodes (MLR) in patients with gastric cancer. We retrospectively analyzed 111 patients who underwent D2 lymph node dissection. The prognostic factors including UICC/AJCC TNM classification and MLR were evaluated by univariate and multivariate analysis. The MLR was significantly higher in patients with a larger tumor, lymphatic vessel invasion, blood vessel invasion and perineural invasion, and advanced stage. Moreover, the MLR was significantly associated with the depth of invasion and the number of lymph node metastasis. The univariate analysis revealed for overall survival (OS) that stage of disease, lymphatic vessel invasion, blood vess... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2960352 Tue, 03 Nov 2009 14:16:35 +0100 2960352 http://www.medworm.com/index.php?rid=2947853&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr2754k570w485286%2F Abstract  Antifungal prophylaxis using fluconazole or itraconazole has been studied for many years but still no consensus has been reached regarding their safety and effectiveness. We performed a systematic meta-analysis to assess the efficacy of fluconazole compared to itraconazole in neutropenic patients with hematological malignancies. We gathered the data for our analysis from MEDLINE, EMBASE, Cochrane-controlled trials register, Cochrane Library, and Science Citation Index (1/1990 to 1/2009) searches. Risk ratio (RR) and 95% confidence intervals (CIs) were calculated using the random effect model. Nine RCTs were identified that were published in full text. Significantly, fewer patients were withdrawn from the studies due to the development of adverse effects with fluco... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2947853 Fri, 30 Oct 2009 07:41:24 +0100 2947853 http://www.medworm.com/index.php?rid=2947852&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa22m85432p33jhj0%2F In this study, we first analyzed the NHE1 expression in 100 cases of hepatocellular carcinoma (HCC) and found that NHE1, at both messenger RNA and protein levels, was over-expressed in majority of HCC tissues compared with matched non-cancerous tissue. In addition, the increased expression of NHE1 correlated with tumor size, venous invasion and advanced pTNM stage (P < 0.05). Kaplan–Meier curves demonstrated that patients with increased NHE1 expression were at significantly increased risk for shortened survival time (P < 0.05). This is the first demonstration that the expression level of NHE1 is correlated with tumor progression and prognosis in HCC. We proposed that NHE1 may have diagnostic and therapeutic potential for patients with HCC. Content Type Jo... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2947852 Fri, 30 Oct 2009 07:41:24 +0100 2947852 http://www.medworm.com/index.php?rid=2947851&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Frhh3mj7j136566rp%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s12032-009-9322-9Authors Ali Alkan, Hacettepe University School of Medicine Department of Internal Medicine Ankara TurkeyUgur Sahin, Hacettepe University School of Medicine Department of Internal Medicine Ankara TurkeyKadri Altundag, Hacettepe University Institute of Oncology Department of Medical Oncology 06100 Sihhiye, Ankara Turkey Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2947851 Fri, 30 Oct 2009 07:41:24 +0100 2947851 http://www.medworm.com/index.php?rid=2936164&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg1k77615g6100400%2F Abstract  The aim of the study was to evaluate the influence of the MDR1 C3435T polymorphism on the therapeutic response in 23 patients treated with cetuximab plus irinotecan for irinotecan refractory liver metastatic colorectal cancer considering their KRAS status. Indeed, irinotecan and its active metabolite (SN-38) are both substrates of P-glycoprotein (P-gp) encoded by MDR1. Patients received cetuximab and irinotecan up to progression. The overall survival was 55% at 10 months. Overall, four patients had an undetermined KRAS status and two patients with mutated KRAS were in progression disease. The response to treatment was observed after 3 months among the 17 wild-type KRAS patients. Two patients presented a progressive disease (1 TT and 1 CT), eight patients had... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2936164 Tue, 27 Oct 2009 18:07:10 +0100 2936164 http://www.medworm.com/index.php?rid=2936165&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg46j1562v20p31v2%2F Abstract  An extremely rare case of primary small cell carcinoma of the pleura with an emphasis on KIT and platelet-derived growth factor receptor-α (PDGFRA) genes is reported here. A 67-year-old man underwent left testicular orchiectomy because of a testicular tumor. The tumor was immunohistochemically shown to be diffuse large B-cell lymphoma. The patient was treated with chemotherapy and radiation and followed up in our hospital. Eight years after the orchiectomy, the patient (75 years old) developed left pleural tumor and pleural effusion, and a biopsy was performed. The biopsy revealed a medullary malignant tumor consisting of small round and spindle cells. The following three possibilities were considered: recurrent lymphoma, mesothelioma, and small cell carcinoma... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2936165 Tue, 27 Oct 2009 09:05:58 +0100 2936165 http://www.medworm.com/index.php?rid=2936166&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy511106m48m22505%2F Abstract  Curcumin is a naturally occurring polyphenolic compound found in the turmeric, which is used as food additive in Indian cooking and as a therapeutic agent in traditional Indian medicine. Curcumin is currently under investigation as a chemotherapeutic and chemopreventive agent in adult cancer models at both pre-clinical and clinical levels. In this preliminary study, we show that curcumin is effective in causing cell cycle arrest, inducing apoptosis, and suppressing colony formation in the Ewing sarcoma cell line SK-NEP-1. Curcumin causes upregulation of cleaved caspase 3 and downregulation of phospho-Akt, producing apoptosis in Ewing sarcoma cells at an inhibitory concentration 50% (IC50) of approximately 4 μM. Our findings indicate a need for further evalua... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2936166 Tue, 27 Oct 2009 09:05:57 +0100 2936166 http://www.medworm.com/index.php?rid=2924204&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F088538405r124335%2F The objective of this study was to evaluate the clinicopathologic presentation and outcome of patients with appendiceal tumors treated at our institution over a 15-year period. We identified patients with appendiceal tumors diagnosed or treated at our institution from January 1989 through May 2004. Chart review for age, gender, signs and symptoms at diagnosis, and treatment was performed. Review of the pathologic specimens was performed and tumors were classified as DPAM, PMCA I/D, or PMCA. Forty patients were identified (median age 52.5 years; males 38%). The number of patients with DPAM, PMCA I/D, and PMCA was 15 (38%), 6 (15%), and 18 (46%), respectively. Peritoneal involvement was seen in 11 (73%) of patients with DPAM, 5 (83%) of PMCA I/D, and 11 (61%) of PMCA. The median s... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2924204 Thu, 22 Oct 2009 18:41:18 +0100 2924204 http://www.medworm.com/index.php?rid=2921363&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu5m1m3p58h176j4u%2F We present a case of seizures after intrathecal administration of methotrexate, during the management of diffuse large B-cell lymphoma. There was complete resolution of the CNS lesions after chemotherapy along with the interval development of diffuse cerebral edema. We hypothesize that tumor lysis is the underlying mechanism of this untoward event, resulting in the corresponding clinical presentation. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9338-1Authors Lohith S. Bachegowda, Hahnemann University Hospital/Drexel University College of Medicine Department of Internal Medicine Philadelphia PA 19102 USAPetros D. Grivas, Hahnemann University Hospital/Drexel University College of Medicine Department of Internal Medicine Philadelphia PA 19102 USARachna An... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2921363 Thu, 22 Oct 2009 06:09:55 +0100 2921363 http://www.medworm.com/index.php?rid=2921364&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb6696307443454l1%2F Abstract  We aimed to investigate the prognostic significance of neutrophil, lymphocyte, platelet, mean platelet value (MPV), platelet-lymphocyte ratio (PLR) and neutrophil–lymphocyte ratio (NLR) in patients with locally advanced gastric cancer (LAGC). One hundred sixty-eight patients with LAGC who had been followed-up between 2004 and 2008 were included in present study. The results of hematological (platelet, lymphocyte, neutrophil and MPV) and biochemical (uric acid and LDH) parameters were evaluated before treatment. NLR was divided into two groups as <2.56 and ≥2.57 and PLR was also divided into two groups as ≤160 and >160. Platelet counts and lymphocyte counts were also divided into two groups; ≤300.000/mm3 and >300.000/mm3, and <1,500/mm3 and ≥1,... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2921364 Thu, 22 Oct 2009 06:09:53 +0100 2921364 http://www.medworm.com/index.php?rid=2921365&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj1512q84p1424856%2F We report a 47-year-old patient with localised breast cancer who developed thrombotic microangiopathy (HUS/TTP) acutely following concurrent neoadjuvant therapy with trastuzumab and docetaxel. We demonstrate from our case that mild confusion occurring on a background of mild anaemia and thrombocytopenia may sometimes be the only clue to the diagnosis. Clinicians should be aware of the possibility of thrombotic microangiopathy associated with trastuzumab and docetaxel therapy, as early intervention can improve clinical outcome. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9333-6Authors Keith Siau, Great Western Hospital Department of Medicine SN3 6BB Swindon UKMohini Varughese, Musgrove Park Hospital Department of Oncology TA1 5DA Taunton UK Jour... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2921365 Thu, 22 Oct 2009 06:09:52 +0100 2921365 http://www.medworm.com/index.php?rid=2917502&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft285575275h13345%2F Abstract  Tamoxifen is an orally active selective estrogen receptor modulator that is used in the treatment of breast cancer and is currently the world’s largest selling drug for that purpose. However, it has some side effects including hot flashes, menstrual irregularity, vaginal discharges, uterine bleeding, uterine endometrial cancer, hypercoagulability, steatosis hepatis, risk of trombembolism. Long-term data from clinical trials have failed to demonstrate a cardioprotective effect and beneficial effects on serum lipid profiles. Arrhythmia secondary to tamoxifen is very rare. Content Type Journal ArticleCategory Letter to the editorDOI 10.1007/s12032-009-9334-5Authors Ladislav Slovacek, Charles University Hospital Faculty of Medicine, Department of Clinical Oncolog... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2917502 Wed, 21 Oct 2009 12:12:28 +0100 2917502 http://www.medworm.com/index.php?rid=2905933&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbur34v4173566363%2F Abstract  Functional polymorphisms in the thiopurine methyl transferase (TPMT) gene have been associated with varying levels of enzyme activity and the occurrence of toxicity related to thiopurines. A total of 98 patients (66 pediatric and 32 adults) with precursor B acute lymphoblastic leukemia (Pre-B ALL) were evaluated for TPMT gene polymorphisms. The inability to tolerate 6-mercaptopurine (6-MP) at conventional doses was considered as a surrogate marker of hematologic toxicity. The allele frequency of TPMT*2, *3A, *3B and *3C in the study population was 0.5, 0, 0 and 2.6%, respectively, similar to the frequency observed in other Asian populations. Five patients were heterozygous for TPMT*3C variant allele, and one of these patient’s was compound heterozygous with TPMT... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2905933 Thu, 15 Oct 2009 06:28:58 +0100 2905933 http://www.medworm.com/index.php?rid=2905932&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk7881622mv388124%2F Abstract  Neutropenic fever is an important cause of morbidity and mortality during therapy of acute myeloid leukemia (AML). We retrospectively analyzed 382 febrile episodes encountered during induction and consolidation chemotherapy to determine the potential etiology, microbiologic spectrum, response/resistance to antibiotics and outcome. Between May, 2001 and December, 2006, 95 patients with de novo non-M3 AML received remission induction chemotherapy followed by consolidation in those who achieved complete remission. Patients median age was 28 years, ranging from 2 to 61 years, 26 patients were ≤15 years of age. There were 57 males and 38 females. Febrile neutropenia was defined as per international guidelines. A total of 382 febrile episodes were recor... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2905932 Thu, 15 Oct 2009 06:28:58 +0100 2905932 http://www.medworm.com/index.php?rid=2905931&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F43430570g1461766%2F We report a case of paraneoplastic hypercalcemia, resistant to conventional treatment but recovers by sunitinib treatment as the first case in the literature, in a 33-years-old man with metastatic RCC. At the sixth month of follow-up period, in this case, serum calcium level was still in normal ranges. Besides sunitinib is effective in symptom control, it is also helpful in management of paraneoplastic hypercalcemia, a life-threatening entity. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s12032-009-9327-4Authors Halit Karaca, Erciyes University Medical Faculty Departments of Medical Oncology Kayseri TurkeyAyhan Lale, Erciyes University Medical Faculty Departments of Internal Medicine Kayseri TurkeyMustafa Dikilitas, Erciyes University Medical Faculty Departments ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2905931 Thu, 15 Oct 2009 06:28:58 +0100 2905931 http://www.medworm.com/index.php?rid=2905934&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F328138j20326uk68%2F Abstract  Serum concentrations of tissue polypeptide-specific antigen (TPS) and Cytokeratin-19-Fragments (CYFRA 21-1) before operation or chemotherapy have been proved to be a useful prognostic tool for patients with NSCLC, but the related data for advanced NSCLC patients treated with gefitinib are limited. We retrospectively reviewed 122 advanced NSCLC patients treated with gefitinib between April 2002 and August 2007. Multiple clinical factors including pretreatment serum levels of TPS and CYFRA 21-1, age, gender, performance status (PS), smoking history, stage, histology, the number of prior chemotherapy and the patients’ clinical outcomes were analyzed. Patients without elevated serum TPS levels had a more RR (36.8%) than those with elevated serum TPS levels (18.5%) (... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=2905934 Thu, 15 Oct 2009 06:28:57 +0100 2905934