MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Medical Oncology' source. Wed, 08 Feb 2012 08:41:48 +0100 http://www.medworm.com/index.php?rid=5666797&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F85055473656832w7%2F Abstract  The role of tumor-infiltrating T cell subsets in the prognosis of non-Hodgkin’s lymphoma (NHL) has previously been reported. In the present study, we investigated the prognostic significance of different T cell subsets in the peripheral blood of NHL patients. Immunophenotyping was performed on the peripheral blood samples of 45 patients with newly diagnosed B cell NHL using flow cytometry. The relationship between T cell subsets of CD4+, CD8+, CD3+CD25+, CD4+CD25+, CD4+CD25high [as T regulatory cells (T reg)], and the CD4/CD8 ratio with international prognostic index (IPI) and response to therapy was determined. The percentages of CD3+, CD4+, and CD8+ T cells in the peripheral blood of the patients were 49.1 ± 20.3%, 23.6 ± 11%, and 31.... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5666797 Fri, 03 Feb 2012 17:51:42 +0100 5666797 http://www.medworm.com/index.php?rid=5666799&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv6146127l0h32730%2F Abstract  Dendritic cells may be successfully used to induce in vivo-specific anti-tumor responses when combined with the appropriate antigen in the appropriate context. The purpose of this study was to evaluate efficacy of peptide-loaded DC vaccine in high-risk stage III melanoma patients after lymph node dissection (LND). HLA-A2+, -A1+, or -A3+ melanoma patients (N = 22), stage III, N1b-N3, received 5–16 (median: 11) DC vaccines loaded with MHC class-I-restricted melanoma peptides respective to the patient’s haplotype, and with autologous tumor lysate, if available. Vaccinated patients were matched to unvaccinated stage III controls (22 of 869) by sex, number of metastatic lymph nodes, extracapsular involvement, LND type, Breslow stage, and ulceration. Vaccin... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5666799 Thu, 02 Feb 2012 18:16:09 +0100 5666799 http://www.medworm.com/index.php?rid=5666798&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd15177j211738vv7%2F This study aimed to investigate the relationship of LAPTM4B allelic variation and GBC susceptibility. LAPTM4B genotype was analyzed in 155 healthy individuals and 91 GBC patients by PCR, and the genotypic distribution of LAPTM4B was analyzed with the chi-squared test. The frequency of allele *2 was 37.9 and 24.8% in the GBC and the control groups, respectively, representing a significant difference between these two groups (P < 0.001). LAPTM4B allele *2 may be a risk factor associated with genetic susceptibility to GBC. Content Type Journal ArticleCategory Original PaperPages 1-5DOI 10.1007/s12032-012-0173-4Authors Hua Yang, Department of Cell Biology, School of Basic Medical Sciences, Peking University, Beijing, 100191 ChinaGuojun Zhai, Department of Interventional R... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5666798 Thu, 02 Feb 2012 18:16:09 +0100 5666798 http://www.medworm.com/index.php?rid=5659453&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp7012225j3654833%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s12032-012-0172-5Authors Tanja Badovinac-Črnjević, Oncology Department, University Hospital Zagreb, Kispaticeva 12, Zagreb, CroatiaGiulio Spagnoli, Institute of Research and Hospital Management, University of Basel, Basel, SwitzerlandAntonio Juretić, Oncology Department, University Hospital Zagreb, Kispaticeva 12, Zagreb, CroatiaJasminka Jakić-Razumović, Pathology Department, University Hospital Zagreb, Kispaticeva 12, Zagreb, CroatiaPaula Podolski, Oncology Department, University Hospital Zagreb, Kispaticeva 12, Zagreb, CroatiaNera Šarić, Oncology Department, University Hospital Zagreb, Kispaticeva 12, Zagreb, Croatia Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncolog... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5659453 Tue, 31 Jan 2012 07:11:08 +0100 5659453 http://www.medworm.com/index.php?rid=5659454&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx500683723202223%2F Abstract  Hypoxia-induced factors (HIFs) play a central role in the adaptive mechanisms of cancer cells to survive under conditions of hypoxia. HIFs are regulated by prolyl hydroxylases (PHDs) among which PHD3 is implicated as a tumor suppressor. We aimed to correlate PHD3 expression with clinicopathologic parameters and to evaluate its prognostic significance in gastric cancer. The 101 tissue samples were collected from 83 resected stages I–IV gastric cancer patients, which were grouped as non-cancerous mucosa (n = 18) and primary carcinoma (n = 83). PHD3 expression was evaluated by immunohistochemistry. We adopted Pearson chi-square test, univariate analysis, multivariate analysis and Kaplan–Meier method. The positive frequency of PHD3 in cancer ce... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5659454 Tue, 31 Jan 2012 07:11:07 +0100 5659454 http://www.medworm.com/index.php?rid=5647201&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw61708060n603n22%2F Abstract  Brain metastasis is a frequent occurrence in lung cancer, especially non-small cell lung cancer (NSCLC), the prognosis for NSCLC with brain metastasis is very poor. Our previous study found high S100B expression in the brain-specific metastatic NSCLC line PC14/B, suggested S100B is closely correlated with brain metastasis in NSCLC. However, the details have not yet been revealed. The aim of this study was to investigate the correlation between S100B and brain metastasis in NSCLC and to study the effects of S100B on non-brain metastatic NSCLC line PC14. We investigated serum S100B levels in 30 newly diagnosed NSCLC patients (15 with brain metastasis and 15 without brain metastasis) using enzyme-linked immunosorbent assay. Results showed that serum S100B levels were ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5647201 Fri, 27 Jan 2012 17:56:11 +0100 5647201 http://www.medworm.com/index.php?rid=5638198&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F541253100527270n%2F This study results indicates that especially PF β2 M and ferritin levels may be valuable for diagnosis of malignant ascites in patients with ovarian neoplasms. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s12032-012-0165-4Authors Umran Kucukgoz Gulec, Department of Obstetrics and Gynecology, Faculty of Medicine, Cukurova University, Adana, TurkeySemra Paydas, Department of Medical Oncology, Faculty of Medicine, Cukurova University, Adana, TurkeyAhmet Baris Guzel, Department of Obstetrics and Gynecology, Faculty of Medicine, Cukurova University, Adana, TurkeySelim Buyukkurt, Department of Obstetrics and Gynecology, Faculty of Medicine, Cukurova University, Adana, TurkeyGulsah Seydaoglu, Department of Biostatistics, Faculty of Medicine, Cukurova Unive... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5638198 Tue, 24 Jan 2012 18:13:18 +0100 5638198 http://www.medworm.com/index.php?rid=5638199&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl06047210746l242%2F Abstract  The laryngeal squamous cell carcinoma (LSCC) is one of the most common cancers threatening people’s life. CXC-chemokine receptor type 2 (CXCR2) was reported to play critical roles in angiogenesis, tumorigenesis, and metastasis of several cancers such as colon cancer, melanoma, lung cancer, and so on. However, the expression of CXCR2 in LSCC and its association with clinical characters of LSCC remain unclear. Quantitative real-time reverse transcription-PCR and immunohistochemistry were used, respectively, to analyze the mRNA level and protein level of CXCR2 in 109 cases of LSCC tissues and 28 cases of tumor-adjacent normal tissues. The expression of CXCR2 in LSCC was significantly higher than that in tumor-adjacent tissues. Moreover, the expression level of CXCR... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5638199 Tue, 24 Jan 2012 18:13:16 +0100 5638199 http://www.medworm.com/index.php?rid=5638200&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkl95t3p3u443170v%2F In this study, we investigate whether gene expression profiling of cervical cancer could be used to predict the prognosis of patient. A series of 100 primary cervical cancer patients who underwent radical hysterectomy between January 2001 and October 2006 were analyzed for gene expression profiles by using a custom oligonucleotide microarray containing probes for 1440 human tumor-related gene transcripts. Supervised analysis of gene expression data identified 19 genes that exhibited differential expression between cervical cancer and normal cervix. Then, all 100 patients were divided into the training (n = 50) and testing sets (n = 50). Using Cox regression and risk-score analysis, we identified a 7-gene (UBL3, FGF3, BMI1, PDGFRA, PTPRF, RFC4, and NOL7) signature f... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5638200 Tue, 24 Jan 2012 18:13:14 +0100 5638200 http://www.medworm.com/index.php?rid=5638201&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx0q25vw734808l81%2F Abstract  The CD146 cell membrane adhesion molecule is highly expressed on the cell surface of several tumours. The level of its expression has been found to correlate directly with tumour progression and metastatic potential, thus establishing CD146 as an important candidate of tumour growth and metastasis. In order to characterize its expression in human osteosarcoma (OS) cell lines, we have examined the CD146 expression at protein and RNA levels in both normal and tumour osteoblast-like cell lines by several methods. Our results indicate that CD146 protein is expressed at low levels in normal osteoblast cells whereas it is highly expressed in all OS cell lines analysed, (SaOS, MG-63, U-2OS). Moreover, CD146 overexpression was partially reduced in shYY1 cells, where the Y... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5638201 Tue, 24 Jan 2012 06:54:28 +0100 5638201 http://www.medworm.com/index.php?rid=5638203&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6635033670104xu8%2F Abstract  Integrins mediate cell-extracellular matrix (ECM) interaction and play a critical role in cell proliferation, migration, survival, and invasion. Polymorphisms of the Integrin gene can alter integrin protein expression, which may further increase the risk of malignancies or cause poor clinical outcomes. The aim of this study was to investigate the potential associations of single-nucleotide polymorphisms (SNPs) of the integrin gene with the susceptibility and clinicopathologic parameters of oral squamous cell carcinoma (OSCC). Two hundred patients with OSCC and 200 healthy volunteers were recruited. Five SNPs of Integrin genes were analyzed by polymerase chain reaction–restriction fragment length polymorphism genotyping. Their correlations with OSCC risk and clinic... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5638203 Tue, 24 Jan 2012 06:54:27 +0100 5638203 http://www.medworm.com/index.php?rid=5638202&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Few5l852k28229833%2F Abstract  A 48-year-old man was referred to our hospital with the diagnosis of colon cancer with multiple hepatic metastases. After right hemicolectomy, the rapid progression of liver disease was treated with metronomic capecitabine and bevacizumab according to a study protocol. A gradual regression of metastatic lesions was observed during a 9-month treatment period. After conversion of liver disease to resectability, the histological examination disclosed the complete necrosis of all lesions, with the exception of small neoplastic foci inside a single nodule. The comparison of this type of histological findings with the classic sclero-hyaline pathological response, as well as its importance as indicator of response to antiangiogenic treatment, is discussed. Content Ty... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5638202 Tue, 24 Jan 2012 06:54:27 +0100 5638202 http://www.medworm.com/index.php?rid=5638204&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv52116715j281505%2F In this study, we investigated the association of the polymorphisms in the DNA repair genes, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys, with endometrium cancer risk. Two hundred and sixty-two women were included in the study. Endometrial biopsy was performed, and on the basis of diagnosis and histological examination, women were divided into two groups: a control group (n = 158) and an endometrial cancer group (n = 104). Genotypes were determined by PCR–RFLP assays in endometrial carcinoma patients and age-matched controls. In this study, we found that the frequencies of Glu+ and Asp/Glu genotypes in APE, Gln/Gln genotype of XRCC1, Met/Met genotype of XRCC3, Cys+ and Ser/Cys genotypes of HOGG1, His+ and ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5638204 Tue, 24 Jan 2012 06:54:26 +0100 5638204 http://www.medworm.com/index.php?rid=5619772&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu677004788897441%2F Abstract  To study the role of SHP-1 methylation in the pathogenesis of myelodysplastic syndromes (MDS), we detect the methylation status of SHP-1 promoter and STAT3 phosphorylation of MDS patients by the methylation-specific PCR and Western blotting, respectively. It is found that the methylation rate of SHP-1 promoter of high-risk MDS patients (69.2%) was higher than that of the low-risk MDS patients (21.4%) (P = 0.001). The expression rate of STAT3 phosphorylated protein of high-risk group was higher (66.7%), when compared with that of the low-risk group (18.2%) (P = 0.0001). Correlation analysis showed that the methylation status of SHP-1 promoter is positive correlated with the expression of phosphorylated STAT3 in MDS patient (P < 0.001... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5619772 Thu, 19 Jan 2012 06:55:04 +0100 5619772 http://www.medworm.com/index.php?rid=5619773&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj5576142549236q5%2F Abstract  Despite recent advances in radiotherapy and chemotherapy, survival rates for squamous cell carcinoma of the head and neck (SCCHN) have remained poor. The focus of SCCHN therapy has more recently shifted to the molecular level, particularly the epidermal growth factor receptor (EGFR/ErbB) pathway. Several agents that target the EGFR pathway, including monoclonal antibodies and tyrosine kinase inhibitors, are under investigation for SCCHN. Searches of PubMed and results of key oncology congresses were performed to identify relevant articles and abstracts. The EGFR-targeted monoclonal antibody cetuximab is approved for the treatment of locally advanced SCCHN in combination with radiotherapy, for first-line treatment of recurrent or metastatic SCCHN in combination wit... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5619773 Wed, 18 Jan 2012 07:00:09 +0100 5619773 http://www.medworm.com/index.php?rid=5597041&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flx821lp8045ph2g1%2F We report a case of cerebral radiation necrosis 5 years after radiotherapy for a maxillary sinus carcinoma. Content Type Journal ArticleCategory Review ArticlePages 1-3DOI 10.1007/s12032-011-0141-4Authors Madhava R. Kanakamedala, Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USAAli Mahta, Department of Neurosciences, Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, San Diego, La Jolla, CA 92093-0819, USAJianlin Liu, Center for Stroke and Vascular Neurology, First Affiliated Hospital Medical College, Xi’an JiaoTong University, Xi’an, ChinaSantosh Kesari, Department of Neurosciences, Moores UCSD Cancer Center, University of California, 3855 Health Sciences Drive, San Diego, La Jolla, CA 92093-0819, US... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5597041 Sat, 14 Jan 2012 16:42:21 +0100 5597041 http://www.medworm.com/index.php?rid=5597042&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7213780p72244078%2F Abstract  VEGFR-1-mediated signaling promotes invasiveness by direct tumor activation in some cancers. However, VEGFR-1 expression and its relationship with clinical features and prognosis in HCC remained unclear. Overexpression of Snail is common in HCC and associated with poorer prognosis. Therefore, expression of VEGFR-1 and Snail was investigated in HCC cell lines and tissue specimens in our study, and special attention was paid to evaluating the role of VEGFR-1 expression in prognosis of HCC. Western blot and immunofluorescence were used to detect expression of VEGFR-1, Snail and MMP-9 in 4 HCC cell lines, respectively. Moreover, expression of these proteins was confirmed on the samples from 95 HCC patients who underwent curative resection using immunohistochemistry. R... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5597042 Sat, 14 Jan 2012 06:54:33 +0100 5597042 http://www.medworm.com/index.php?rid=5597044&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj4572p65m5v87656%2F Abstract  CD133 has been identified as a putative cancer stem cell (CSC) marker in various cancers including colorectal cancer. The relation between CD133 expression and biological characteristics of colorectal cancer remains to be clarified. Protein expression of CD133 was immunohistochemically evaluated in surgical specimens of 225 patients with colorectal cancer who were treated by surgery, as well as those of 78 patients with rectal cancer who received preoperative chemoradiotherapy (CRT) followed by curative resection. The correlation between CD133 expression and clinicopathological features, tumor recurrence and overall survival was analyzed in both populations. Among 225 colorectal cancers without CRT, 93 (41.3%) were positive for CD133 expression, which was enhanced... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5597044 Fri, 13 Jan 2012 16:51:25 +0100 5597044 http://www.medworm.com/index.php?rid=5597043&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb72218l771298223%2F Abstract  Survivin has been shown to be an ideal target for cancer gene therapy because of its strong antiapoptotic effect. MicroRNA-34a (miR-34a) can function as a tumor suppressor in some cancers through negative regulation of gene expression. However, the relationship between miR-34a and survivin in larynx squamous cell carcinoma (LSCC) has not been explored. The abundance of survivin mRNA and miR-34a in LSCC tissues were measured using quantitative real-time polymerase chain reaction. Their expression levels were analyzed and correlated with tumor differentiation, lymphatic metastasis, clinical stages, and survival rates. MiR-34a mimic was transfected using liposomes to increase its level in LSCC cancer cell line, Hep-2. The effects of miR-34a on survivin protein expres... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5597043 Fri, 13 Jan 2012 16:51:25 +0100 5597043 http://www.medworm.com/index.php?rid=5597045&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr27k332h26u67424%2F Abstract  We investigated the role of N-acetyltransferases (NAT) in prostate cancer (PCa) susceptibility. NAT are polymorphic in the population and metabolize important carcinogenic products directly involved in the tumor initiation process. This prospective case–control study utilized the polymerase chain reaction-based restriction fragment length polymorphism method and comprised a cohort of consecutive 478 individuals: 126 men with prostate cancer; 101 men with benign prostatic hyperplasia (BPH); and a control health population of 177 female and 74 male blood donors from the same region. NAT2 slow or fast acetylators genotypes were determined by the combination of four variant alleles. Lifetime occupational history, dietary patterns, cigarette smoking and other anamnest... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5597045 Fri, 13 Jan 2012 16:51:24 +0100 5597045 http://www.medworm.com/index.php?rid=5597046&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw7rk265jmg57k005%2F Abstract  Karyotype of myeloblasts at the time of AML diagnosis has been shown to be prognostic significant for pre-remission outcome and outcome after allo-SCT, but the latter requires further studies. We conducted a retrospective analysis of the impact of intermediate and unfavourable cytogenetics at the time of primary diagnosis on outcome after allo-SCT in de novo AML. The study included 169 patients who underwent allo-SCT at Karolinska University Hospital between 1980 and 2010. Intermediate and unfavourable cytogenetics were found in 129 (76%) and 40 patients (24%), respectively. Myeloablative and reduced-intensity conditioning were given to 120 (71%) and 49 (29%) patients, respectively. Allo-SCT was performed in CR1 in 122 patients (72%). TRM was 16% in both cytogenet... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5597046 Tue, 10 Jan 2012 16:49:53 +0100 5597046 http://www.medworm.com/index.php?rid=5581102&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1h2671h5637758v8%2F In conclusion, PKM2 and PFK-1 genes are associated closely with cervical carcinoma. The enhanced expressions of PKM2 and PFK-1 indicate one developing signal of cervical carcinoma. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s12032-011-0154-zAuthors Yang Yuan, School of Public Health, Central South University, Changsha, 410078 Hunan, ChinaPeng Guo-Qing, Department of O & G, Xiangya Hospital Central-South University, Changsha, 410008 Hunan, ChinaTian Yan, Department of O & G, Xiangya Hospital Central-South University, Changsha, 410008 Hunan, ChinaYing Hong-Lin, Department of O & G, Xiangya Hospital Central-South University, Changsha, 410008 Hunan, ChinaHu Gong-Hua, School of Public Health, Central South University, Changsha, 410078 Hunan, ChinaZhong Cai-G... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5581102 Sat, 07 Jan 2012 16:56:35 +0100 5581102 http://www.medworm.com/index.php?rid=5572003&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F555302116h328256%2F Abstract  Radiosensitivity is a biological response to radiation. This response depends on many factors such as radiation factors as well as biological system factors. It is shown that identical doses of radiation for the treatment of Cancer patients produce different biological responses that are assumed to be depend on different specifications of the biological systems. However, by elimination of these factors, people may still show different biological responses such as acute and low responses to radiotherapy in similar doses of radiation. Some reports indicate that breast cancer, immune diseases including autoimmune diseases such as lupus, Myasthenia Gravies and even the rate of allergy are more frequent in left-handed compared to right-handed individuals. The main goal... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5572003 Wed, 04 Jan 2012 17:03:03 +0100 5572003 http://www.medworm.com/index.php?rid=5572005&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc3005l3888311585%2F Abstract  The aim of this study was to identify novel serological tumor markers for human prostate cancer (PCa). We compared the gene expression profile of PCa tissues to adjacent benign tissues of prostate using gene expression microarray. 1207 genes that were consistently different from adjacent benign tissues of prostate (paired t test, P < 0.05) were selected as differentially expressed genes (DEGs). Among them, 652 DEGs were upregulated in PCa, whereas 555 DEGs were downregulated in PCa. In addition, two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) coupled with MS was performed to screen for candidate markers in the proteome of PCa and adjacent benign tissues of prostate. A total of 89 spots were significantly up-regulated (ratio �... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5572005 Wed, 04 Jan 2012 07:00:21 +0100 5572005 http://www.medworm.com/index.php?rid=5572004&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl925k4rg90113192%2F In this study, we aimed to search for the amplification of the locus bearing CIAP-2 and its relation to HPV-16 in head and neck cancer that may have prognostic and therapeutic impacts on these patients. Total 30 patients diagnosed as head and neck cancer (2 tissue samples were taken from each patient: from the tumor and from the safety margin). All samples were subjected to qualitative polymerase chain reaction analysis for HPV-16 and qualitative and semiquantitative reverse transcription polymerase chain reaction of CIAP-2. There was a significant association between HPV-16 and CIAP2 positivity and head and neck tumors (P = 0.01). CIAP-2 expression in malignant tissues was highly associated with HPV-16 infection with 73.9% sensitivity and absolute specificity. Content... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5572004 Wed, 04 Jan 2012 07:00:21 +0100 5572004 http://www.medworm.com/index.php?rid=5559580&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl0317420wmr6h640%2F We present long-term disease treatment in a 60-year-old woman having greater than thirty brain metastases of NSCLC adenocarcinoma with a mutant allele of EGFR treated with differing chemotherapies including erlotinib, but disease response in the brain only with bevacizumab. Although initially restricted in use, increasing clinical reports have demonstrated safety of bevacizumab use in brain-involved cancer patients. Our case highlights that disease response to bevacizumab is similar in the brain to systemic disease and likely overcomes anatomical barriers that can limit other therapeutic agents. Content Type Journal ArticleCategory Short CommunicationPages 1-4DOI 10.1007/s12032-011-0148-xAuthors Oana C. Danciu, Department of Medicine, Section of Hematology/Oncology, University ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5559580 Fri, 30 Dec 2011 16:43:30 +0100 5559580 http://www.medworm.com/index.php?rid=5559582&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F38684q0048136153%2F Abstract  Chronic myelogenous leukemia (CML) is a common myeloproliferative disease that is characterized by the clonal expansion of marrow stem cells, and is associated with the Philadelphia chromosome. As the disease progresses, additional chromosome abnormalities may arise. The prognostic impact of secondary chromosomal abnormalities in CML is complex, heterogeneous, and sometimes related to previous treatment. Here, we describe a CML patient in lymphoid blast crisis associated with a new chromosomal abnormality identified, dic(7;12)(p12.21;p12.2) and i(12)(q10) using classical cytogenetics and spectral karyotype analysis. To the best of our knowledge, this is the first report of t(7;12)(p11.1;q11.1) and i(12)(q10) in a CML patient with lymphoid evolution. Content Ty... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5559582 Fri, 30 Dec 2011 16:43:29 +0100 5559582 http://www.medworm.com/index.php?rid=5559581&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk885x154q7840730%2F Abstract  MicroRNAs (miRNAs) are of great importance in pathogenesis, diagnosis and prognosis of acute leukemia (AL). We studied five AL-related miRNAs to confirm the significance of these miRNAs in AL. Samples tested included acute myeloid leukemia (AML), 107 cases; acute lymphoblastic leukemia (ALL), 40 cases. Five AL-related miRNAs: miR-128, let-7b, miR-223, miR-181a and miR-155 expression were detected by qRT-PCR. Analysis showed that miRNA-128 expression was significantly higher in ALL (P < 0.001). However, the let-7b and miR-223 expressions in ALL were significantly lower than in AML (P < 0.001). Compared with normal controls, miR-128 expression was significantly higher in ALL (P < 0.001), but there was no significant difference in ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5559581 Fri, 30 Dec 2011 16:43:29 +0100 5559581 http://www.medworm.com/index.php?rid=5559583&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr488l2746678532v%2F Abstract  The efficacy of bevacizumab combined with infusional 5-fluorouracil/leucovorin (5-FU/LV) plus irinotecan (FOLFIRI) as the second-line treatment for metastatic colorectal cancer (mCRC) has not been fully clarified, although bevacizumab combined with infusional 5-FU/LV plus oxaliplatin (FOLFOX) in the second-line setting has demonstrated a survival benefit. We investigated the efficacy of bevacizumab plus FOLFIRI in mCRC patients who failed oxaliplatin-containing regimens without bevacizumab. Patients who received bevacizumab plus FOLFIRI or bevacizumab plus FOLFOX as second-line chemotherapy between July 2007 and March 2008 were registered (trial registration: UMIN000001547). Patient background data and progression-free survival (PFS), overall survival (OS), respon... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5559583 Fri, 30 Dec 2011 16:43:26 +0100 5559583 http://www.medworm.com/index.php?rid=5559584&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F11pjl4171x58888n%2F In this study, we aimed to investigate the relationship between LAPTM4B allelic variation and HCC susceptibility. The LAPTM4B genotype was analyzed in the blood samples from 102 HCC patients and 135 healthy individuals by PCR. The genotypic distribution of LAPTM4B was analyzed using the chi-squared test. The frequencies of allele *2 were 38.24 and 24.07% in the HCC group and control group, respectively, representing a significant difference between these two groups (P < 0.001). Thus, allele *2 of LAPTM4B appears to be associated with genetic susceptibility of HCC and may therefore be considered as a risk factor. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s12032-011-0139-yAuthors Guojun Zhai, Department of Interventional Radiology and Vascu... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5559584 Fri, 30 Dec 2011 07:09:17 +0100 5559584 http://www.medworm.com/index.php?rid=5552148&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgn8m2g18824j13r8%2F Abstract  Acute promyelocytic leukemia (APL) is characterized by the presence of the t(15;17) and PML-RARa rearrangement, with good response to treatment with retinoids. However, few cases of variant APL involving alternative chromosomal aberrations have been reported, including t(11;17)(q23;q21) (Wells et al. in Nat Genet 17:109–113, 1; Arnould et al. in Hum Mol Genet 8:1741–1749, 2) t(5;17)(q35;q12-21), t(11;17)(q13;q21) (Grimwade et al in Blood 96:1297–1308, 3) and der(17) (Rego et al. in Blood (ASH Annual Meeting Abstracts)114:Abstract 6, 4), whereby RARa is fused to the PLZF, NPM, NuMA, and STAT5b genes, respectively, have been described. These cases are characterized by distinct morphology, clinical presentation, and in respect to PLZF, a lack of differentiation re... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5552148 Wed, 28 Dec 2011 16:44:11 +0100 5552148 http://www.medworm.com/index.php?rid=5552149&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa518451518005876%2F Abstract  This case report focuses on an elderly gentleman with extensive stage small cell lung cancer (SCLC) who experienced episodes of bowel obstruction shortly after commencing first-line chemotherapy with cisplatin and etoposide. The patient had no radiological or pathological evidence of intra-abdominal carcinomatosis or paraneoplastic bowel disease secondary to SCLC. Although neurotoxicity is commonly associated with platinum agents, the effect is predominantly peripheral as opposed to autonomic. The authors conclude that the observations documented in this case were secondary to etoposide; a podophyllotoxin that can bind microtubules and inhibit fast axonal transport. Although paralytic ileus is well recognised with podophyllotoxin poisoning, to our knowledge, this ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5552149 Tue, 27 Dec 2011 17:01:56 +0100 5552149 http://www.medworm.com/index.php?rid=5552150&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr72322321rh09215%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s12032-011-0146-zAuthors Julio Cesar Salas-Alanis, Department of Dermatology, Facultad de Medicina y Hospital Universitario Dr. José E. González, Universidad Autonoma de Nuevo Leon, Avenida Gonzalitos No. 235 Norte, Colonia Mitras Centro, CP64460 Monterrey, Nuevo León, MexicoRoger Gonzalez, Department of Dermatology, OnDerm. Centro de Dermatología, Dermatoscopía y Oncología Cutánea, Av. Loma Grande 2717-M6, Col. Lomas de San Francisco, Monterrey, Nuevo León, MexicoGiulio Fortuna, Program in Epithelial Biology, Department of Dermatology, Stanford University School of Medicine, 269 Campus Dr., Stanford, CA 94305, USA Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medic... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5552150 Tue, 27 Dec 2011 17:01:55 +0100 5552150 http://www.medworm.com/index.php?rid=5552151&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F640u635485244595%2F Abstract  The aim of this study was to perform an immunohistochemical analysis from 100 megakaryocytes per sample, analyzing positivity and intensity levels of anti-LAP human TGF-β1 (or Latent TGF-β1) and anti-TGF-β1 (or Active TGF-β1) antibodies from 18 essential thrombocythemia (ET) and 38 primary myelofibrosis (PMF) patients (being 19 pre-fibrotic and 19 fibrotic). Six bone marrow donor biopsies were used as controls. Fibrosis in bone marrow biopsies (BMB) was evaluated according to the European Consensus. The average fibrosis grade differed between each group (P = 0.001 or P = 0.003). Latent TGF-β1 values differed significantly between pre-fibrotic (P = 0.018) and fibrotic (P = 0.031) groups when compared with the control group. The... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5552151 Mon, 26 Dec 2011 16:45:23 +0100 5552151 http://www.medworm.com/index.php?rid=5552152&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc17g98461151g1v5%2F Abstract  We aimed to compare the survival benefit of transarterial chemoembolization (TACE) with conservative treatment for patients with advanced hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT), furthermore, to reveal which PVTT types benefit from TACE treatment. From August 2007 to January 2010, a prospective controlled study was performed on consecutive patients with advanced HCC and PVTT. Of a total of 150 patients, 115 were treated with TACE (lipiodol and anticancer agents ± gelatin sponge embolization), and 35 who refused to accept the procedure were treated with conservative treatment. We performed survival analysis of the two treatment groups and then stratified by a new classification of PVTT that was divided into four types. Overall survival... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5552152 Mon, 26 Dec 2011 16:45:22 +0100 5552152 http://www.medworm.com/index.php?rid=5544267&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm121768481p89h12%2F In this study, the in vitro cytotoxicity, antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) activities of anti-Sp17 mAb were evaluated using Sp17-positive ovarian cancer cells as targets, Sp17-negative ovarian cancer cells as the control, and healthy human peripheral blood monocytes and healthy human serum as effectors. Our preliminary results indicate that the direct cytotoxicity of anti-Sp17 mAb against the investigated ovarian cancer cells was very weak. However, the cytotoxicity of anti-Sp17 mAb, mediated by peripheral blood mononuclear cells (PBMCs), as ADCC, or by human serum, as CDC, was relatively strong in the Sp17-positive ovarian cancer cells. This finding suggested that anti-Sp17 mAb could be a useful tool against ovarian can... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5544267 Fri, 23 Dec 2011 16:54:29 +0100 5544267 http://www.medworm.com/index.php?rid=5544266&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F68882k7pr2786l14%2F Abstract  Diffuse large B-cell lymphoma (DLBCL) is characterized by its clinical and biological heterogeneity. Although the International Prognostic Index (IPI) provides a clinical model for risk stratification of patients with DLBCL, notable variability in outcome is still observed within the same IPI category. Tumor-infiltrating macrophages (also called Tumor-associated macrophages) are the major component in the microenvironment of DLBCL. Their correlation with the prognosis of DLBCL remains controversial. Using a CD68 antibody in immunohistochemical analysis, we studied the expression of CD68 in 112 Chinese patients with DLBCL, with 65 patients (58%) categorized as low CD68 expression and 47 patients (42%) as high CD68 expression. The complete response (CR) rate of pati... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5544266 Fri, 23 Dec 2011 16:54:29 +0100 5544266 http://www.medworm.com/index.php?rid=5544268&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff674257015035661%2F Abstract  The expression of EphA2 and three epithelial–mesenchymal transition-related proteins (E-cadherin, β-catenin and vimentin) was detected by immunohistochemistry in human gastric cancer and normal gastric mucosa. The expression of EphA2 and vimentin was significantly higher in gastric cancer tissues than in normal gastric mucosa tissues, and similar results were found for negative E-cadherin expression and ectopic β-catenin expression. Further analysis showed that the expression of EphA2 was closely correlated with the depth of tumor invasion, tumor–node–metastasis (TNM) stages and lymph node metastasis. Down-regulated expression of the epithelial protein E-cadherin, overexpression of the mesenchymal protein vimentin and ectopic expression of β-catenin were ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5544268 Wed, 21 Dec 2011 20:08:56 +0100 5544268 http://www.medworm.com/index.php?rid=5537493&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm40x504t283q516m%2F Abstract  Perturbations in the apoptotic genes have been implicated in human malignancies. The purpose of the present study was to investigate the polymorphisms of -938C/A, Thr43Ala in anti-apoptotic B-cell lymphoma 2 gene (BCL2) and -248G/A in pro-apoptotic B-cell lymphoma 2-associated X protein gene (BAX) and to explore their role in influencing the susceptibility for development of esophageal cancer. A total of 205 esophageal cancer patients and 224 controls were enrolled in the present study. The genotype and allele distributions of -938C/A, ala43thr in BCL2 and -248G/A in BAX were analyzed in patients and controls, as well as the association of -938C/A genotype with clinical characteristics in patients. We found that homozygous -938A/A genotype of BCL2 gene was signifi... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5537493 Tue, 20 Dec 2011 16:48:34 +0100 5537493 http://www.medworm.com/index.php?rid=5524223&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx84761145278k484%2F Abstract  Arginine deprivation impairs cell proliferation more strong in cancer than in normal cells; thus, it has been proposed that such an effect could be exploited for cancer therapy. We have compared the effect of arginine deprivation on normal and cancer cells, studying growth rate, morphology, and protein expression patterns in immortalized human MCF10a cells and in MCF7 cells. Arginine deprivation forces MCF10a cells into irreversible senescence while the vast majority of MCF7 cells become quiescent and resume normal growth following arginine re-addition. Arginine deprivation induced a significant burst of p21cip1 in both cell lines that were reversible in MCF7 and irreversible in MCF10 cells. In the latter cells, p21cip1 increase was accompanied by a time-dependent i... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5524223 Mon, 19 Dec 2011 16:54:13 +0100 5524223 http://www.medworm.com/index.php?rid=5515175&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8464063552215272%2F Abstract  The aim of this study was to evaluate the prognostic significance of international prognostic index (IPI), mantle cell lymphoma IPI (MIPI), simplified MIPI (sMIPI), and MIPI biological (MIPIb), as well as their correlation with immunophenotype, clinical characteristics, and overall survival (OS), in a selected group of 54 patients with advanced-stage mantle cell lymphoma (MCL), treated uniformly with CHOP. Seventeen patients had IV clinical stage (CS), while other 37 had leukemic phase at presentation. Diffuse type of marrow infiltration was verified in 68.5% and nodular in remainder patients. Extranodal localization (25.9%) included bowel (20.4%), pleural effusion, sinus, and palpebral infiltration. All of analyzed patients expressed typical MCL immunophenotypic ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5515175 Wed, 14 Dec 2011 16:43:11 +0100 5515175 http://www.medworm.com/index.php?rid=5515176&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp464880318600757%2F In this study, we demonstrated that gastric cancer tissues and cell lines displayed a consistent down-regulation of miR-148a and hypermethylation of promoter region. DNMT1 was over-expressed in primary tumors and cell lines, while knockdown of DNMT1 using siRNA could decrease methylation level of miR-148a promoter and restore its expression. Furthermore, ectopic over-expression of miR-148a in cancer cell lines caused reduction in DNMT1 expression and inhibited cell proliferation, but no obvious change was found in apoptosis rate. These results suggest that miR-148a is inactivated by DNA hypermethylation of promoter region in gastric cancer, which is mediated through DNMT1 over-expression. Additionally, the silence of miR-148a reduces its suppression to DNMT1 in gastric cancer, and th... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5515176 Tue, 13 Dec 2011 17:03:38 +0100 5515176 http://www.medworm.com/index.php?rid=5515177&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn4811q267r772437%2F In conclusion, reduced IGFBP-3 expression may be a risk factor for advanced clinicopathological classification and poor patient survival. These findings suggest that IGFBP-3 may serve as a useful marker for the prognostic evaluation of ESCC patients. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s12032-011-0133-4Authors Lei Zhao, Department of Radiotherapy, Cancer Center, Sun Yat-Sen University, Guangzhou, No 651, Dongfeng road east, Guangzhou, 510060 ChinaLi-Ru He, Department of Radiotherapy, Cancer Center, Sun Yat-Sen University, Guangzhou, No 651, Dongfeng road east, Guangzhou, 510060 ChinaRui Zhang, Department of Radiotherapy, Cancer Center, Sun Yat-Sen University, Guangzhou, No 651, Dongfeng road east, Guangzhou, 510060 ChinaMu-Yan Cai, State Key Lab... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5515177 Tue, 13 Dec 2011 17:03:37 +0100 5515177 http://www.medworm.com/index.php?rid=5504417&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh5n2m85m86120520%2F Abstract  Despite multimodal treatment, patients with astrocytoma still face a poor survival, and identification of valuable prognostic factors is crucial to yield effective individual therapy strategies. The aim of this study was to investigate progranulin (PGRN) expression in astrocytomas and explore its association with tumor grade and overall patient survival by scoring the PGRN immunoreactivity of both tumor cells and blood vessels. About 210 astrocytoma samples with different WHO grades and 14 normal brain tissues were studied by immunohistochemistry for PGRN. Semi-quantitative RT-PCR and Western blot were carried out to confirm its expression in 35 tumor specimens. Serum levels of PGRN in glioblastoma were examined by enzyme immunometric assay. PGRN expression was al... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5504417 Mon, 12 Dec 2011 17:17:09 +0100 5504417 http://www.medworm.com/index.php?rid=5494707&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe81k45m146285563%2F Abstract  Imatinib is a powerful protein tyrosine kinase (PTK) inhibitor that specifically targets BCR-ABL, KIT, and PDGFR kinases, has become the current first-line therapy for all newly diagnosed chronic myeloid leukemia (CML). Beside PTKs, PTK inhibitors alter the activity of a large number of voltage-dependent ion channels. hERG1 K+ channels are highly expressed in leukemia cells and appear of exceptional importance in favoring leukemogenesis. The present study explored a possible regulatory effect of imatinib upon hERG1 K+ channels as a means to uncover new molecular events involved in the antileukemic activity of this PTK inhibitor in CML. The results demonstrated that hERG1 was highly detected in K562 cells and primary CML cells, and down-regulated by imatinib at mRNA... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5494707 Fri, 09 Dec 2011 17:08:35 +0100 5494707 http://www.medworm.com/index.php?rid=5486497&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F18w81135x346893t%2F Abstract  There is an intimate relation between disturbance in survivin and SMAC/DIABLO expressions and cancer formation in many tissues; however, this was not confirmed in the primary breast cancer. The aim of this study was to evaluate the relationship between survivin and SMAC/DIABLO mRNA expressions in primary breast cancer using RT-PCR and their relationship to some of the risk factors (age, family history, breast-feeding, use of contraceptive pills and hormonal receptors). Breast cancer tissues were studied for the detection of the mRNA expression of survivin and SMAC/DIABLO. This was done by qualitative reverse transcription–polymerase chain reaction (RT-PCR). SMAC/DIABLO mRNA was detected by RT-PCR only in 1 sample in breast cancer tissues (6.25%). However, it was... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5486497 Wed, 07 Dec 2011 16:44:39 +0100 5486497 http://www.medworm.com/index.php?rid=5486496&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1n032r5553152606%2F Abstract  Corticosteroids are the mainstay of treatment of inflammatory pseudotumor (IPT) of the head and neck; however, involvement of the skull base and mandible can be unresponsive to steroids and require surgical resection. IPT is known to usually contain a CD20+ lymphocyte subgroup. Rituximab, a chimeric anti-CD20 antibody, has been successfully utilized in the treatment of other CD20+ diseases, including the similar idiopathic orbital inflammatory disease. This is the first report to describe successful treatment with Rituximab of a recurrent IPT of the mandible with trigeminal spread and leptomeningeal involvement with clinical and radiologic evidence demonstrating a sustained response to therapy. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.10... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5486496 Wed, 07 Dec 2011 16:44:39 +0100 5486496 http://www.medworm.com/index.php?rid=5486498&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Femv410800h54j205%2F Abstract  Alcohol dehydrogenase 4 (ADH4) is an important member of ADH family that metabolize a wide variety of substrates including ethanol and retinol. Studies demonstrated that ADH4 was involved in cancer. Microarray data showed that the expression of ADH4 was reduced in hepatocellular carcinoma (HCC). However, the role of ADH4 in HCC carcinogenesis remains undefined. The aim of this study is to explore the clinical significance of ADH4 in progression and prognosis of HCC. The expression levels of ADH4 in 15 paired HCC and noncancerous (NC) liver tissues were measured by qRT-PCR and those in 4 paired samples by Western blotting. Another 91 paraffin-embedded HCC tissues were examined by immunohistochemistry. The qRT-PCR result showed that the expression level of ADH4 mRNA... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5486498 Tue, 06 Dec 2011 17:00:45 +0100 5486498 http://www.medworm.com/index.php?rid=5476242&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyk98u18t65134g5k%2F Abstract  A disintegrin and metalloproteinase-17 (ADAM17, also named as tumor necrosis factor-alpha-converting enzyme) is a member of the ADAM family. Of all ADAMs, the strongest evidence for a role in malignancy exists for ADAM17. Especially, it has been demonstrated that ADAM17 expression was significantly increased in human gastric cancer. The aim of this study was to investigate the association between ADAM17 expression and the clinicopathological features of patients with gastric cancer. The expression of ADAM17 was detected by real-time quantitative RT-PCR in gastric cancer and adjacent non-cancerous tissues. In addition, ADAM17 expression was analyzed by immunohistochemistry in 220 clinicopathologically characterized gastric cancer cases. The expression levels of ADA... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5476242 Fri, 02 Dec 2011 17:29:12 +0100 5476242 http://www.medworm.com/index.php?rid=5476243&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F55v5427556564128%2F Abstract  Recent studies have demonstrated that N-Myc downstream-regulated gene 2 (NDRG2) may reduce the metastatic potential of breast cancer and hepatocellular carcinoma cells by regulating the expression of CD24, which is expressed in a large variety of solid tumors. The aim of this study was to clarify the clinical value of NDRG2 and CD24 expression in primary gallbladder carcinoma (GBC). One hundred and thirty GBC tissues were evaluated by immunohistochemistry for NDRG2 and CD24 expression. The associations of NDRG2 and CD24 expression with the clinicopathological characteristics and the overall survival of patients with GBC were analyzed. NDRG2 and CD24 were positively expressed in 49/130 (37.69%) and 107/130 (82.31%) of GBC tissues, respectively. In addition, the tum... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5476243 Thu, 01 Dec 2011 19:22:11 +0100 5476243 http://www.medworm.com/index.php?rid=5468510&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd7255111021u8m53%2F Content Type Journal ArticleCategory PUBLISHER NOTEPages 1-1DOI 10.1007/s12032-011-0124-5 Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5468510 Wed, 30 Nov 2011 18:40:26 +0100 5468510 http://www.medworm.com/index.php?rid=5449585&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkw7803u2v0457kh7%2F This study was designed to investigate the association of apoptosis-related gene Caspase 8, Caspase 9 and Bcl-2 polymorphisms with papillary thyroid carcinoma (PTC) susceptibility. We undertook a case–control study of 118 patients and 213 controls to investigate the association between Caspase 8 (-652 6 N ins/del), Caspase 9 (-1263 A>G) and Bcl-2 (-938 C>A) polymorphisms and PTC susceptibility by polymerase chain reaction restriction–fragment length polymorphism and DNA sequencing methods. We further analyzed the distribution of genotype frequency, as well as the association of genotype with clinicopathological characteristics. Overall, no statistically significant association was observed in Caspase 8 (-652 6 N ins/del). Nevertheless, Caspase 9 -1263 GG genotype wa... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5449585 Fri, 25 Nov 2011 17:42:47 +0100 5449585 http://www.medworm.com/index.php?rid=5449586&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj4466212104j775t%2F In conclusion, the author presents three cases of primary pure SRCA with an emphasis of immunohistochemical findings. Content Type Journal ArticleCategory Original PaperPages 1-4DOI 10.1007/s12032-011-0122-7Authors Tadashi Terada, Department of Pathology, Shizuoka City Shimizu Hospital, Miyakami 1231 Shimizu-Ku, Shizuoka, 424-8636 Japan Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5449586 Fri, 25 Nov 2011 17:42:46 +0100 5449586 http://www.medworm.com/index.php?rid=5449588&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F44mg8301007061n2%2F Abstract  To investigate the expression status and the clinical implications of Girdin protein in breast cancer. The expression status of Girdin protein and clinicopathological parameters in 820 breast cancer specimens was analyzed using immunohistochemistry staining and the relationship between Girdin protein and clinicopathological parameters. The prognosis of breast cancer was subsequently determined. Girdin protein was expressed positively in 295 (35.98%) of the 820 cases examined. The expression of Girdin protein was related to histological type and CerbB2 (P = 0.001, 0.006, and 0.001, respectively). After analyzing survival rates, the cases with highly expressed Girdin protein were shown to attain a significantly more distant metastasis rate and poorer postop... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5449588 Thu, 24 Nov 2011 17:53:27 +0100 5449588 http://www.medworm.com/index.php?rid=5449587&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc163644p81975704%2F Abstract  Recent studies indicate that ER/PR/HER-2-negative (triple-negative, TN) breast cancers may be “CTA-rich” tumors, suggesting the possibility of CTA-based cancer vaccines as a treatment option for patients bearing these tumors. MAGE-A10 together with NY-ESO-1 is probably the most immunogenic CTA, representing a potentially highly attractive target of active specific immunotherapies. Paraffin-embedded tumor sections were collected retrospectively from 165 breast cancer patients diagnosed between 2002 and 2003. Immunohistochemical staining for MAGE-A10 and NY-ESO-1 was performed. The expression of MAGE-A10 and NY-ESO-1 was correlated with other clinicopathological variables. MAGE-A10 expression (score ≥ 2+) was detected in 105/164 (64%), and NY-ESO-1 ex... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5449587 Thu, 24 Nov 2011 17:53:27 +0100 5449587 http://www.medworm.com/index.php?rid=5449589&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb3233k1384h533w0%2F In this study, array comparative genomic hybridization (aCGH) was used to distinguish eight cases of AML cases. Validation was performed by FISH and quantitative genomic PCR. The aCGH revealed new large and small recurrent genomic imbalances, such as gains of 1p36, 10q26, 11p15, 20q13, 22q23, harboring many proto-oncogenes. These results better define genetically the studied cases and could be used to understand the multiple phenomena involved in leukemogenesis. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s12032-011-0108-5Authors Ana Rosa S. Costa, Division of Hematology and Hemotherapy, UNIFESP/Escola Paulista de Medicina, Rua Botucatu, 740, 3º andar, São Paulo, SP CEP: 04023-900, BrazilSintia I. Belangero, Division of Genetics, UNIFESP/Escola... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5449589 Thu, 24 Nov 2011 17:53:26 +0100 5449589 http://www.medworm.com/index.php?rid=5449590&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcr347k2mh76h8500%2F This study demonstrates that pre-miR-30c A/G polymorphism may be associated with an increased risk of gastric cancer in a Chinese population through altering mature miR-30c expression. However, their role as novel biomarkers for the diagnosis and prognosis of gastric diseases still needs to be systematically evaluated. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s12032-011-0115-6Authors Yong-ping Mu, Department of Cell Biology, Capital Medical University, Beijing, 100069 ChinaXiu-lan Su, Department of Cell Biology, Capital Medical University, Beijing, 100069 China Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5449590 Tue, 22 Nov 2011 17:59:31 +0100 5449590 http://www.medworm.com/index.php?rid=5449591&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F30t64r2318272366%2F This study sought to investigate recurrence patterns of GBM treated with temozolomide-based chemoradiation. Records for 31 patients treated for newly diagnosed GBM between 2007 and 2009 were retrospectively analyzed. Ten patients received maximal surgical resection followed by conventionally fractionated radiation (CFR) to a median dose of 60 Gy with concurrent and planned adjuvant temozolomide. Twelve patients were treated with maximal surgical debulking, intracavitary brachytherapy (ICB), and external beam radiation therapy with concurrent and planned adjuvant temozolomide. The remaining 9 patients had unresectable disease and underwent biopsy followed by a hypofractionated course of radiation to a median dose of 60 Gy over 10 fractions. Tumor failure was classified as l... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5449591 Tue, 22 Nov 2011 17:59:29 +0100 5449591 http://www.medworm.com/index.php?rid=5440402&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F21qr512627m3n727%2F Abstract  Dysadherin is a cancer-related cell membrane glycoprotein, recently identified, playing an important role in tumor progression and metastasis. In the present minireview article, we are focusing on the role of dysadherin in E-cadherin downregulation, the various expression patterns of the molecule in head and neck cancer as well as its potential role as a molecular target for future applications in diagnosis, clinical routine and prognosis of the disease. Content Type Journal ArticleCategory Review ArticlePages 1-5DOI 10.1007/s12032-011-0118-3Authors Alexandros Georgolios, Department of Otorhinolaryngology, Virginia Commonwealth University, Richmond, VA, USAAnna Eleftheriadou, Department of Otorhinolaryngology, General Hospital of Rethymnon, P.O. Box 269, 74100... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5440402 Mon, 21 Nov 2011 18:09:23 +0100 5440402 http://www.medworm.com/index.php?rid=5440403&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0k352gm84jp00774%2F Abstract  Apoptin, a 13.6-kD protein encoded by chicken anemia virus, is paid more and more attention, since it selectively induces apoptosis in tumor cells while abolishes cytotoxic effect in normal cells. In addition, Apoptin shows different localization in tumor cells and normal cells: it predominantly accumulates in nucleus of tumor cells, whereas in normal cells, it is detected mainly in cytoplasm. There are various mechanisms implicated in the program of Apoptin-mediated cell death. Up to now, the interpretations have been recognized including that the particular domains control nucleocytoplasmic shuttling of Apoptin, phosphorylation on specific residue and varies relevant signaling contribute to Apoptin’s activity, and the partners interacted with Apoptin regulate ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5440403 Mon, 21 Nov 2011 18:09:21 +0100 5440403 http://www.medworm.com/index.php?rid=5440404&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp046757562542760%2F This study acted to determine the methylation status of the ERβ promoter and its correlation with clinicopathological features of sporadic breast cancers in Chinese women, and lay a foundation for the management of breast cancer. In total, 178 cases with sporadic breast cancers were enrolled in the study. ERβ methylation was determined using a methylation-specific polymerase chain reaction (MSP). In general, ERβ promoter methylation was found in 44.9% (80/178) of breast tumor samples, significantly higher than the benign breast hyperplasia (44.9% vs. 14.3%, X 2 = 4.986, P = 0.026). A total of 58% (40/69) of ERβ-negative tumors got methylation compared with 36.7% (40/109) of ERβ-positive cases being methylated (X 2 = 7.728, P = 0.005). The ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5440404 Mon, 21 Nov 2011 18:09:20 +0100 5440404 http://www.medworm.com/index.php?rid=5431432&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq3357v4212438204%2F Abstract  The significance of translation regulatory factors in elevating the risk of cancer has been recently recognized. Eukaryotic release factor 3a (eRF3a) is a translation termination protein that is encoded by G1 to S phase transition 1 gene (GSPT1). The eRF3a/GSPT1 exon 1 contains a trinucleotide GGC repeat coding for a polyglycine expansion in the N-terminal of the protein. In the present study, we determined the allelic length of the GGCn repeat in the eRF3a gene in 250 women with breast cancer and 250 age-matched controls. Our results show that the presence of the longer allele, 12-GGC, is correlated with threefold increased risk of breast cancer development. Our findings also suggest that women who are homozygous for 7-GGC allele are possibly at higher risk of deve... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5431432 Fri, 18 Nov 2011 17:30:22 +0100 5431432 http://www.medworm.com/index.php?rid=5431433&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F068h46v877825q56%2F In conclusion, the results showed the silibinin effectson reducing the rate of metastasis, migration and adhesion of MDA-MB-231 to distant organs. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s12032-011-0113-8Authors Mohadeseh Dastpeyman, Department of Molecular and Cellular Biology, University of Tehran, Tehran, IranNasrin Motamed, Department of Molecular and Cellular Biology, University of Tehran, Tehran, IranKayhan Azadmanesh, Department of Virology, Pasteur Institute of Iran, Tehran, IranEhsan Mostafavi, Department of Epidemiology, Pasteur Institute of Iran, Tehran, IranVahid Kia, Department of Virology, Pasteur Institute of Iran, Tehran, IranAli Jahanian-Najafabadi, Department of Molecular Biology, Pasteur Institute of Iran, Tehran, IranMohammad Ali ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5431433 Fri, 18 Nov 2011 17:30:21 +0100 5431433 http://www.medworm.com/index.php?rid=5431435&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff731326m83430454%2F This study investigated the expression pattern of vasohibin-1, its correlation with clinicopathological features, and its potential role in tumor angiogenesis and prognosis of HCC. Expression of vasohibin-1, vascular endothelial growth factor-A (VEGF-A), and intratumoral microvessel density (MVD, labeled by CD34) were assessed by immunohistochemistry in 117 HCC specimens and adjacent nontumor liver tissues (ANLT). Correlation between vasohibin-1 and VEGF-A, MVD, and clinicopathological features was then investigated. Prognostic value of these factors was determined using Kaplan–Meier analysis and a Cox proportional hazards regression model. Cytoplasm high expression of vasohibin-1 was detected in 38.5% (45/117) of the HCC tissues, which was significantly higher than that in 16.2% (... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5431435 Fri, 18 Nov 2011 17:30:20 +0100 5431435 http://www.medworm.com/index.php?rid=5431434&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp23661v866247864%2F Abstract  Drug resistance remains a major clinical obstacle to successful treatment in breast cancer patients, and the evidence of microRNAs involvement in cancer drug resistance has been emerging recently. However, the role of microRNA-200c (miR-200c) in modulating chemoresistance of breast cancer remains largely unexplored. Here, we investigated the miR-200c expression in tumor specimens obtained from thirty-nine breast cancer patients who received neoadjuvent chemotherapy by quantitative real-time PCR. Down-regulated miR-200c was observed in non-responders as compared to responders. In addition, miR-200c expression was observed to be down-regulated over 800-fold in human breast cancer cells resistant to doxorubicin MCF-7/ADR as compared to the parental MCF-7 cells. Up-reg... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5431434 Fri, 18 Nov 2011 17:30:20 +0100 5431434 http://www.medworm.com/index.php?rid=5421722&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0284822577626153%2F Abstract  To explore the clinical implication of activin receptor-like kinase 7 (ALK7) expression in breast cancer, we evaluated its protein level in six kinds of human breast tissue samples, including adjacent normal tissues, adenosis, breast fibroadenoma, ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC), and lymph node metastases (LNM). Immunohistochemical analyses showed that ALK7 was more frequently and much more intensely expressed in adjacent normal tissues, adenosis, and fibroadenoma tissues than in malignant tissues (DCIS, IDC, and LNM). Furthermore, the ALK7 expression in primary tumors and the corresponding LNM was evaluated in parallel samples from 60 patients with IDC. Results showed that the ALK7 expression status in primary tumors and LNM was c... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5421722 Tue, 15 Nov 2011 16:50:00 +0100 5421722 http://www.medworm.com/index.php?rid=5421724&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7k582u542635072n%2F This study demonstrated that the in vivo responses of malignant cells from CLL patients after administration of purine analogs (cladribine/fludarabine) with cyclophosphamide vary significantly. For comparative purposes, the sensitivity of leukemic cells obtained from the same CLL patients to conventional purine analogs and the selective CDK inhibitor R-roscovitine (ROSC) was determined, with and without the addition of an alkylating agent, prior to the onset of in vivo therapy. The kinetics and rate of spontaneous and drug-induced apoptosis of CLL cells under ex vivo conditions differed significantly between patients, mirroring the variability observed during in vivo treatment. Interestingly, individual patients’ leukemic cells were comparably sensitive to the drugs under both cond... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5421724 Tue, 15 Nov 2011 16:49:59 +0100 5421724 http://www.medworm.com/index.php?rid=5421723&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff86501362h742w24%2F This report is the first to investigate the expression and clinical significance of pRON in human ESCC. Quantitative polymerase chain reaction revealed an up-regulation of RON mRNA in 70% (7/10) of ESCC tissues when compared to the adjacent nontumor tissues. An overexpression of pRON protein was found in most of the ESCC cell lines studied (4/5) when compared to two non-neoplastic esophageal epithelial cells using immunoblot. In 64 ESCC tissues, pRON was localized at the cell membrane, cytoplasm and nucleus in 15 (23.4%), 63 (98.4%) and 61 (95.3%) cases using immunohistochemistry. Patients having high expression of cytoplasmic pRON significantly associated with shorter median survival when compared to those with low expression (25.41 months vs. 14.43 months), suggesting cy... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5421723 Tue, 15 Nov 2011 16:49:59 +0100 5421723 http://www.medworm.com/index.php?rid=5421725&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn040u14k14n02r20%2F Abstract  It has been suggested that type 2 diabetes mellitus may affect breast cancer prognosis, possibly due to increased diabetes-related comorbidity, or direct effects of insulin resistance and/or hyperinsulinemia. The aim of this study was to determine the impact of diabetes on disease-free survival (DFS) following mastectomy for breast cancer patients. The cases included in this retrospective study were selected from breast cancer women who had undergone mastectomy and completed adjuvant chemotherapy from 1998 to 2010. Patients were classified into two groups: diabetic and non-diabetic. Patients’ age, sex, menopausal status, body mass index (BMI), histopathological features, tumor size, lymph node involvement, hormone receptor and HER2-neu status, and treatment type... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5421725 Mon, 14 Nov 2011 16:54:33 +0100 5421725 http://www.medworm.com/index.php?rid=5407334&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb3tn107123t01167%2F Abstract  Darbepoetin alfa (DA) is an erythropoiesis-stimulating agent (ESA) approved for treating chemotherapy-induced anemia (CIA). Safety concerns have prompted changes to the ESA-product information, which now recommends initiating ESAs at hemoglobin (Hb) levels <10 g/dL (US) or ≤10 g/dL (EU). The present exploratory analysis of a DA trial examined how baseline-Hb levels at ESA initiation affect transfusion rates, Hb response, and safety outcomes in CIA patients. Data were retrospectively analyzed from a phase 3 trial of CIA patients randomised to 500 mcg DA every 3 weeks (Q3 W) or to 2.25 mcg/kg DA weekly (QW) for 15 weeks. In the current analysis, data were reanalyzed by baseline-Hb categories of <9 g/dL (n = 12... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5407334 Sat, 12 Nov 2011 16:54:39 +0100 5407334 http://www.medworm.com/index.php?rid=5407335&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F467w626443011q34%2F Abstract  The aims of this study were to investigate the frequency and prognostic relevance of CD56 expression in patients with acute myeloid leukemia (AML) and to compare the importance of CD56 expression with standard prognostic factors, such as age, leukocytosis, cytogenetic abnormalities and performance status. We analyzed the data of 184 newly diagnosed patients with non-promyelocytic AML and a follow-up of 36 months. The median patient age was 58 years, with a range of 18–79. CD56+ antigen was recorded in 40 patients (21.7%). CD56 + was the most significant risk factor for OS: P = 0.05. The most significant factor for a poor rate of CR was age ≥ 55 years (P = 0.001). CD56 positivity had no significant influence ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5407335 Fri, 11 Nov 2011 16:45:28 +0100 5407335 http://www.medworm.com/index.php?rid=5407336&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F26q7881165m3m525%2F Abstract  The development of breast cancer is a multistep process associated with complex changes in host gene expression patterns including inactivation of tumor suppressor genes and activation of oncogenes. Critically, hereditary predisposition plays a significant role in cancer susceptibility. However, mutation of the BRCA1 gene is found only in the minority of hereditary breast cancer, which indicates that there might be alternative, novel mechanisms contributing to inactivation of the BRCA1 gene. Studies have shown that aberrant methylation of genomic DNA plays an important role in carcinogenesis. The aim of this study was to investigate whether DNA methylation may be an alternative mechanism for the inactivation of BRCA1 as an epigenetic modification of the genome and w... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5407336 Thu, 10 Nov 2011 16:54:47 +0100 5407336 http://www.medworm.com/index.php?rid=5407339&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F432151v5147gv041%2F Abstract  Breast cancer is the most common type of cancer among women worldwide, and the incidence of breast cancer is increasing in the developing world. Estrogen exposure is a major risk factor for breast cancer, and estrogen oxidative metabolites have been implicated in chemical carcinogenesis. Xeroderma pigmentosum complementary group C (XPC) plays an important and multifaceted role in cell protection from oxidative DNA damage. Thus, XPC inactivation may be involved in the early stage of breast cancer. The aim of this study was to investigate the expression of XPC protein in sporadic breast cancer tissues and determine whether XPC expression influences breast cancer malignancy and clinical outcome. Fifteen cases of adjacent non-tumor breast tissue, 28 cases of fibroaden... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5407339 Tue, 08 Nov 2011 19:14:53 +0100 5407339 http://www.medworm.com/index.php?rid=5407338&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc75p7u477t2n6r25%2F Abstract  The purpose of the study was to evaluate event-free survival (EFS), overall survival (OS) and safety for early addition of arsenic trioxide (As2O3) as frontline consolidation therapy compared to high-dose arabinoside (HiDAC) in adult patients with de novo acute promyelocytic leukemia (APL). 271 patients (aged 17–65 years) received consolidation therapy containing As2O3 (two 21-day courses) or HiDAC regimen. EFS at 5 years was 75% versus 54% (P < 0.001), and OS at 5 years was 83% versus 71% (P = 0.002) in As2O3 and HiDAC treatment arms. 139 patients treated with As2O3, EFS at 5 years reached 79% versus 56% (P = 0.014), but OS at 5 years was 77% versus 84% (P = 0.32) in low-risk (WBC ≤ 10&... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5407338 Tue, 08 Nov 2011 19:14:53 +0100 5407338 http://www.medworm.com/index.php?rid=5407337&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl46541756708k663%2F Abstract  Antisense oligonucleotides (oligos) have been employed against in vivo and in vitro prostate cancer models targeting growth regulatory proteins. In LNCaP cells, we evaluated both monospecific and bispecific oligos that targeted and comparably suppressed the expression of bcl-2, an apoptosis inhibitory protein. Cells compensated with both suppressed caspase-3 (an apoptosis promoter) activity, and an enhancement of both androgen receptor (AR) and p300 expression. This suggests that a progression to increased androgen sensitivity accompanies bcl-2 suppression, in this tumor line. To further evaluate mechanisms of adaptation, we now evaluate the effects upon the expression of insulin-like growth factor (IGF1) and another AR coactivator, IL-4, thought to increase prost... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5407337 Tue, 08 Nov 2011 19:14:53 +0100 5407337 http://www.medworm.com/index.php?rid=5407340&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F37242u56326240g6%2F The objectives of this study are to explore the clinical features and treatment outcomes and to investigate the correlation between microvessel density (MVD) and survival in patients with angioimmunoblastic T-cell lymphoma (AITL). We retrospectively analyzed clinical and follow-up data of 31 patients treated in two hospitals during 1995–2009 histologically proven AITL. We also assessed MVD in the lump of 31 previously untreated patients using α-CD34 immunohistochemical staining. The median age of the 31 patients was 48 years, eighty percent of the patients were in an advanced stage. 67.7% of them had B symptoms, with the follow-up of 2–13 years, the 5-year overall survival rate was 25.8%. The response rates (RR) of CHOP group and COP (cyclophosphamide, vincristine and ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5407340 Tue, 08 Nov 2011 19:14:52 +0100 5407340 http://www.medworm.com/index.php?rid=5407342&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj5855k8763531707%2F Abstract  The global physiological function of specifically expressed genes of prostate cancer in Chinese patients is unclear. This study aims to determine the genome-wide expression of genes related to prostate cancer in the Chinese population. Genes that were differentially expressed in prostate cancer were identified using DNA microarray technology. Expressions were validated by using real-time PCR. The identified genes were analyzed using the ingenuity pathway analysis (IPA) to investigate the gene ontology, functional pathway and network. A total of 1,444 genes (Fold time ≥ 1.5; P ≤ 0.05) were differentially expressed in prostate primary tumor tissue compared with benign tissue. IPA revealed a unique landscape where inductions of certain pathways... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5407342 Tue, 08 Nov 2011 19:14:51 +0100 5407342 http://www.medworm.com/index.php?rid=5407341&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft78102j0372063w6%2F Abstract  In chronic myeloid leukemia (CML), the best characterized imatinib resistance mechanisms are BCR-ABL tyrosine kinase domain mutations and clonal evolution, but recently alternative splicing of BCR-ABL was also proposed as a mechanism for imatinib resistance. Among recently reported BCR-ABL splice variants, exon 7 deletion (Δexon7) was characterized in this study. The frequency of Δexon7 was investigated in 30 healthy controls and in 76 CML patients at different time points of the disease course by four different molecular genetic methods (direct sequencing, fragment analysis, allele-specific and quantitative PCR). The functionality and viability of the variant protein was tested by bioinformatic prediction. The Δexon7 was abundantly detected with similar freque... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5407341 Tue, 08 Nov 2011 19:14:51 +0100 5407341 http://www.medworm.com/index.php?rid=5400294&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh2g1462q05163149%2F Abstract  Mantle cell lymphoma (MCL) is incurable in most patients. Several molecular markers have been identified as possible prognostic factors in MCL, including TP53 mutations. Direct sequencing was used to detect 32 cases with leukemic presentation of MCL form exons 2–11 in order to explore the prognostic significance of TP53 mutations in Chinese patients. Within the MCL cohort, 6(18.8%) patients harbored TP53 mutations. TP53 mutations in the absence of del(17p13) were found in 5.0% of MCL cases (1 of 20) compared with 83.3% of MCL cases (5 of 6) with del(17p13). Compared with patients without TP53 mutations, TP53 mutations were associated with risk factors including age, higher serum lactate dehydrogenase, lymphocytosis, high-risk (HR) international prognostic index,... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5400294 Sat, 05 Nov 2011 17:08:38 +0100 5400294 http://www.medworm.com/index.php?rid=5400295&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq3006517805157tk%2F Abstract  Our aim was to evaluate clinical and pathological features in prognosis of thymoma patients with particular emphasis on patients with myasthenia gravis (MG). From 1995 to 2010, 140 thymoma patients (women/men: 63/77) with a median age of 46 years (11–80 years) were admitted to our institution. According to World Health Organization (WHO), there were 23 (17%) type A, 12 (9%) type AB, 24 (17%) type B1, 42 (31%) type B2 and 36 (26%) type B3. The distribution of Masaoka stages I, II, III and IV was 24 (17%), 71 (51%), 18 (13%) and 27 (19%), respectively. MG coexisted in 61% of patients. After a mean follow-up of 34 months (1–158 months), 102 (73%) patients are alive and well while 14 (10%) are alive with disease. Twenty-three patients (16%) have... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5400295 Sat, 05 Nov 2011 17:08:37 +0100 5400295 http://www.medworm.com/index.php?rid=5400296&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4w70738h4104314g%2F In this study, using RT-PCR and further northern blot validation, we confirmed that miR-378 was significantly differentially expressed in the matched NSCLC from 8 patients with BM and 21 without BM. Our study showed evidences that miR-378 is associated with non-small cell lung cancer brain metastasis by promoting cell migration, invasion and tumor angiogenesis. MiR-378 may be a potential biomarker for characterizing non-small cell lung cancer brain metastasis and assisting clinicians in stratifying the high-risk patients on a clinical trial for either prophylactic cranial irradiation or a new intervention that may mitigate BM development, ultimately leading to a new standard of care for NSCLC patients. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s1203... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5400296 Thu, 03 Nov 2011 16:57:06 +0100 5400296 http://www.medworm.com/index.php?rid=5400298&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F96j016260722u22k%2F Abstract  Gastric cancer remains a significant global health burden with poor treatment outcome. New treatment modalities that target inflammation, proliferation, and angiogenesis have been used in various cancers, including gastric cancer. We sought to study the pattern of expression of two important proteins, cyclooxygenase-2 and epidermal growth factor receptor, and their association with microvascular density, clinicopathological features, and survival in Arab Omani patients with gastric cancer. Formalin-fixed, paraffin-embedded tumors were studied by immunohistochemistry using monoclonal antibodies to cyclooxygenase-2, epidermal growth factor receptor, and CD34. The immunohistochemical results were correlated with clinicopathological features and survival. In our study... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5400298 Wed, 02 Nov 2011 16:45:28 +0100 5400298 http://www.medworm.com/index.php?rid=5400297&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr934u40j583726v2%2F This study was to investigate the expression profile of AQP5 in cervical cancer and its clinical significance. We detected the expression profile of AQP5 mRNA and protein in cervical cancer tissue and in corresponding normal tissue by qRT-PCR and western blotting. Immunohistochemistry was also used in the detection of AQP5 protein expression as well as the proliferation index of Ki-67. The clinicopathological implications of these proteins were analyzed statistically. Survival analysis was performed to assess prognostic significance. AQP5 mRNA was overexpressed in cervical cancer tissue when compared with corresponding normal tissue, so was AQP5 protein. Overexpression of AQP5 was significantly associated with lymph node involvement (P = 0.004). Overexpression of Ki-67 was ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5400297 Wed, 02 Nov 2011 16:45:28 +0100 5400297 http://www.medworm.com/index.php?rid=5400299&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F02x462v68q673756%2F Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s12032-011-0090-yAuthors A. M. Tatli, Faculty of Medicine, Department of Internal Medicine, Medical Oncology, Akdeniz University, 07059 Konyaalti Antalya, TurkeyM. Uysal, Faculty of Medicine, Department of Internal Medicine, Medical Oncology, Akdeniz University, 07059 Konyaalti Antalya, TurkeyS. S. Goksu, Faculty of Medicine, Department of Internal Medicine, Medical Oncology, Akdeniz University, 07059 Konyaalti Antalya, TurkeyD. Arslan, Faculty of Medicine, Department of Internal Medicine, Medical Oncology, Akdeniz University, 07059 Konyaalti Antalya, TurkeyS. Gunduz, Faculty of Medicine, Department of Internal Medicine, Medical Oncology, Akdeniz University, 07059 Konyaalti Antalya, TurkeyM. Ozdogan, Faculty of Medici... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5400299 Mon, 31 Oct 2011 17:02:21 +0100 5400299 http://www.medworm.com/index.php?rid=5360054&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw07w504t1x1h0625%2F Abstract  Perioperative chemotherapy plus surgery improves survival compared to surgery alone in GE junctional (GEJ) and gastric adenocarcinomas. The docetaxel/cisplatin/5-fluorouracil (DCF) combination is superior to CF in patients with metastatic gastric cancer. We retrospectively evaluated the safety and efficacy of preoperative DCF chemotherapy in patients with locally advanced gastric and GEJ cancer. Twenty-one gastric and 10 gastroesophageal junctional (GEJ) cancer patients received 2–3 cycles of preoperative docetaxel 75 mg/m2 and cisplatin 75 mg/m2 on day 1, 5-FU 750 mg/m2 (continuous infusion) on days 1–5 every 3 weeks. Clinical response was evaluated by comparing pre- and postchemotherapy CT scans. Overall survival (OS) and progression-free ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5360054 Fri, 28 Oct 2011 06:01:11 +0100 5360054 http://www.medworm.com/index.php?rid=5335248&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl1q4161p20p41435%2F Abstract  Lactotransferrin (LTF) is a component of the nonspecific immune system, having antimicrobial properties against bacteria, fungi, and several viruses. The gene coding for LTF is polymorphic, with the occurrence of several common alleles in the general population. Our previous study found that LTF inhibited nasopharyngeal carcinoma (NPC) cell proliferation in vitro and in vivo. To better understand one possible mechanism of LTF-mediated antitumor activity in NPC cells, in the present study, we investigated the distribution of LTF gene polymorphisms (rs1126477, rs1126478, rs2073495, and rs9110) in NPC and revealed whether these polymorphisms were associated with LTF gene expression. It was found that rs2073495 and rs9110 were correlated significantly with NPC. The fr... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5335248 Wed, 19 Oct 2011 15:46:37 +0100 5335248 http://www.medworm.com/index.php?rid=5335247&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc3254634u3u144p6%2F Abstract  Novel treatment strategies such as gene therapy are warranted in view of the failure of current treatment approaches to cure a high percentage of patients with advanced bladder cancers. The emergence of cancer gene therapy potentially offers a number of exciting treatments. The majority of approaches involve strategies to suppress the function of activated oncogenes to restore the expression of functional tumour suppressor genes or to initiate tumour self-destruction. One gene therapy approach against tumours that holds great promise is suicide gene therapy. Herpes simplex virus thymidine kinase (HSV-TK) phosphorylates ganciclovir (GCV), which in turn interacts with cellular DNA polymerase and interferes with DNA synthesis to cause death of rapidly dividing cells.... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5335247 Wed, 19 Oct 2011 15:46:37 +0100 5335247 http://www.medworm.com/index.php?rid=5335249&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm8484800l472n95n%2F Abstract  Previous studies have demonstrated that the expression of prostate-specific membrane antigen (PSMA) is restricted to endothelium from tumor-associated neovasculature. But the expression of PSMA in osteosarcoma and its clinical significance are unknown. Using immunohistochemical analysis and quantum dot probes, we found that 46.7% (21/45) of the osteosarcoma showed positive staining for PSMA while no PSMA staining in osteofibrous dysplasia. The expression and localization of PSMA was confirmed by CD34 staining. More importantly, the expression of PSMA is correlated with tumor size, pulmonary metastasis and worse survival (survival rate 63.2% in the PSMA-negative group versus 36.6% in the PSMA-positive group). Thus, PSMA could be used as an independent prognostic ma... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5335249 Wed, 19 Oct 2011 05:56:47 +0100 5335249 http://www.medworm.com/index.php?rid=5323788&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgh3491682681562p%2F Abstract  Recently, accumulating evidence indicates that dysregulation of miRNAs is associated with the initiation and progression of cancer. MiR-101 has been reported down-regulated in various types of cancer. The aim of this study was to investigate the expression profile of miR-101 and its target gene Mcl-1 in NSCLC and to assess their clinical significance. QRT-PCR was used in the detection of miR-101 and Mcl-1 mRNA expression both in NSCLC tissue and in adjacent normal lung tissue. Immunohistochemistry and Western blot analysis were used in the detection of Mcl-1 protein expression. The clinicopathological implications of these molecules were analyzed statistically. Survival analysis was performed to assess prognostic significance. Down-regulation of miR-101 was associ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5323788 Thu, 13 Oct 2011 05:47:52 +0100 5323788 http://www.medworm.com/index.php?rid=5323789&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy807063h5w8j455j%2F Content Type Journal ArticleCategory Review ArticlePages 1-2DOI 10.1007/s12032-011-0078-7Authors Ali Mahta, Department of Neurosciences, Moores UCSD Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093-0819, USAEwa Borys, Department of Neurosciences, Moores UCSD Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093-0819, USASantosh Kesari, Department of Neurosciences, Moores UCSD Cancer Center, University of California San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093-0819, USA Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5323789 Thu, 13 Oct 2011 05:47:51 +0100 5323789 http://www.medworm.com/index.php?rid=5314006&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq602k7r6785q6h60%2F Abstract  Hepatocellular carcinoma (HCC) is usually diagnosed in advanced stage, which causes difficulty of using surgical treatment. Previous studies demonstrated that tyroserleutide (YSL), an immunologically active tripeptide compound, could suppress the proliferation and tumor formation of some liver cancer cell lines. We aimed to investigate the feasibility and toxicity of continuous administration of YSL by a portable infusion pump to patients with advanced HCC and its biologically effective but non-toxic doses used in outpatient setting. Forty patients (12 in stage 1, 28 in stage 2, total 10 treated in each dose cohort) were treated with YSL 6, 12, 18, or 24 mg/day lasting for 5 days. No treatment-related mortality was observed. The overall response rat... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5314006 Tue, 11 Oct 2011 05:48:21 +0100 5314006 http://www.medworm.com/index.php?rid=5314007&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F04g843xx4n208181%2F Abstract  Microarray data suggested that the expression of aldehyde dehydrogenase 1 family member L1 (ALDH1L1) is reduced in hepatocellular carcinoma (HCC). However, the role of ALDH1L1 in HCC carcinogenesis has not been elucidated. In the present study, we investigated the expression of ALDH1L1 in HCC and evaluated its relationship with clinical features and prognosis of HCC patients. Total 112 tumor samples were collected from patients with HCC, who underwent radical hepatectomy. Out of the 112 samples, 16 paired HCC tumorous and corresponding adjacent nontumor tissues were analyzed by real-time quantitative RT-PCR (qRT-PCR) and Western blotting, and the other 96 HCC samples were detected by immunohistochemical method. The qRT-PCR assay showed that the mRNA level of ALDH1... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5314007 Tue, 11 Oct 2011 05:48:19 +0100 5314007 http://www.medworm.com/index.php?rid=5314008&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk3m6583714541073%2F Abstract  A disintegrin and metalloprotease 8 (ADAM8) has been shown to be expressed in various cancer types, and its expression was associated with advanced progression of several tumors. However, little is known about ADAM8 in human gliomas. Therefore, we here evaluated the correlation of ADAM8 expression with the clinicopathological features and prognosis in the patients with gliomas. Immunohistochemistry and western blot were used to investigate the expression of ADAM8 protein, respectively, in 128 patients with gliomas. The expression levels of ADAM8 in glioma tissues were significantly higher (P = 0.002) than those in non-neoplastic brain tissues according to the immunohistochemistry analysis. In addition, a high level of ADAM8 expression was significantly mo... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5314008 Sat, 08 Oct 2011 15:43:22 +0100 5314008 http://www.medworm.com/index.php?rid=5304135&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp4u112736h267w11%2F Abstract  Primary breast invasive ductal carcinoma coexisting with ductal carcinoma in situ (IDC-DCIS) is characterized by lower proliferation rate and metastatic propensity than size-matched pure IDC. IDC-DCIS is also more often ER-positive, PR-positive and/or HER2-positive. This analysis aims to clarify whether the presence of coexisting DCIS in IDC affects tumor aggressiveness in various biological subtypes of breast cancer, respectively. Tumor data obtained from 1,355 consecutive female patients undergoing upfront surgery for primary breast cancer were analyzed retrospectively; 196 patients with pure DCIS were excluded. Based on evidence that immunohistochemistry (IHC) provides a reasonable approximation of molecular phenotypes, the tumor samples were divided into 4 gro... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5304135 Fri, 07 Oct 2011 16:00:29 +0100 5304135 http://www.medworm.com/index.php?rid=5304134&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F836g11337834l4q5%2F Abstract  Post-mastectomy radiation therapy (PMRT) is indicated for local-regionally advanced breast cancer (LABC). We hypothesized that candidates for PMRT from non-urban areas would receive lower rates of RT than urban patients and would have poorer overall survival (OS) and disease-specific survival (DSS). We used the Surveillance, Epidemiology, and End Results database to identify patients diagnosed with LABC and treated with mastectomy in Sacramento and its surrounding 13 counties between 2000 and 2006. All patients were eligible to receive RT according to established guidelines, with tumors >5 cm size, ≥4 metastatic lymph nodes, or both. According to a United States Department of Agriculture scale, we designated counties as urban or non-urban and used multiv... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5304134 Fri, 07 Oct 2011 16:00:29 +0100 5304134 http://www.medworm.com/index.php?rid=5304137&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn7q6364703388r28%2F Abstract  FRA3B and FRA16D are the most sensitive common chromosomal fragile site loci in the human genome and two tumor suppressor genes FHIT (Fragile Histidine Triad) and WWOX (WW domain-containing oxidoreductase gene) map to this sites. The WWOX gene is composed of 9 exons and encodes a 46-kD protein that contains 414 amino acids. Loss of heterozygosity, homozygous deletions, and chromosomal translocations affecting WWOX has been reported in several types of cancer, including ovarian, esophageal, lung and stomach carcinoma, and multiple myeloma. The aim of this study was to determine the role of WWOX as a tumor suppressor gene in patients with breast cancer. Tumor and adjacent non-cancerous tissue samples were obtained from 81 patients with breast cancer. DNA was isolate... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5304137 Fri, 07 Oct 2011 16:00:28 +0100 5304137 http://www.medworm.com/index.php?rid=5304136&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx26k346u8u0351q1%2F We report a case of a woman with metastatic ovarian cancer who developed leptomeningeal carcinomatosis while receiving systemic chemotherapy. We also provide an extensive review of the existing literature on neoplastic meningitis from ovarian cancer. Content Type Journal ArticleCategory Review ArticlePages 1-6DOI 10.1007/s12032-011-0076-9Authors Eliza Miller, Columbia University College of Physicians and Surgeons, 2012 630 West 168th St, New York, NY 10032, USAIrene Dy, Department of Hematology-Oncology, St. Luke’s Roosevelt Hospital, 1000 Tenth Avenue 11G, New York, NY 10019, USAThomas Herzog, Division of Gynecologic Oncology, Columbia University Medical Center, New York, NY, USA Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5304136 Fri, 07 Oct 2011 16:00:28 +0100 5304136 http://www.medworm.com/index.php?rid=5296696&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9341573u6142j4m4%2F Abstract  The molecular mechanisms leading to gastric carcinogenesis still remain unclear. Recently, several studies demonstrated that over-expression of guanylyl cyclase C (GCC) has been detected in intestinal-type gastric cancer (GC) and precursor lesions. Our objective was to explore the expression levels of GCC and endogenous ligands guanylin (GN) and uroguanylin (UGN) and the correlation between Helicobacter pylori (H. pylori) and GCC, GN, and UGN expressions in patients at different stages from normal mucosa to superficial gastritis, atrophic gastritis, intestinal metaplasia (IM), dysplasia, and finally adenocarcinoma. The expression of GCC and GN was absent in the distal normal gastric tissues and superficial gastritis in all cases, whereas they were measured in IM, d... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5296696 Wed, 05 Oct 2011 05:49:20 +0100 5296696 http://www.medworm.com/index.php?rid=5285226&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F51p221h8v01g654p%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12032-011-0073-zAuthors Camillo Porta, I.R.C.C.S. San Matteo University Hospital Foundation, Pavia, ItalyThomas Powles, St. Bartholomew’s Hospital London, London, UK Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5285226 Sat, 01 Oct 2011 06:44:48 +0100 5285226 http://www.medworm.com/index.php?rid=5285227&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft1r330nj1048675r%2F This study was designed to investigate the effects of the polymorphisms of methylenetetrahydrofolate reductase 677 C → T (MTHFR 677 C → T), methylenetetrahydrofolate reductase 1298 A → C (MTHFR 1298A → C), thymidylate synthase (TYMS 3R → 2R), and methionine synthase 2756 A → G (MTR 2756 A → G) on the risk of primary liver cancer (PLC). We conducted a case–control study involving 356 PLC cases and 641 healthy controls in North China. Compared with the MTHFR 677CC genotype, the MTHFR 677TT genotype showed an increased risk for PLC (TT vs. CC: adjusted odds ratio (OR) =  1.56; 95% confidence interval (CI): 1.02–2.40; P = 0.043) after adjusting for gender and age, whereas the MTHFR ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5285227 Thu, 29 Sep 2011 06:06:44 +0100 5285227 http://www.medworm.com/index.php?rid=5273361&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa45837112wp80p04%2F Abstract  Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma. Most of the data available on GISTs derive from retrospective studies of patients referred to oncology centers. The MolecGIST study sought to determine and correlate clinicopathological and molecular characteristics of GISTs. Tumor samples and clinical records were prospectively obtained and reviewed for patients diagnosed in France during a 24-month period. Five hundred and ninety-six patients were included, of whom 10% had synchronous metastases. GISTs originated from the stomach, small bowel or other site in 56.4, 30.2 and 13.4% of cases, respectively. The main prognostic markers, tumor localization, size and mitotic index were not independent variables (P < 0.0001). Mutation... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5273361 Wed, 28 Sep 2011 05:52:34 +0100 5273361 http://www.medworm.com/index.php?rid=5260250&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu31r6x1u5r771762%2F Conclusion: Overexpressed PKP3 is likely to be an essential contributor to a growth-promoting pathway and to aggressive features of breast cancer. Content Type Journal ArticleCategory Original PaperPages 1-5DOI 10.1007/s12032-011-0071-1Authors Guzin Gonullu Demirag, Department of Medical Oncology, Faculty of Medicine, Ondokuz Mayıs University, Kurupelit, Samsun, 55139 TurkeyYurdanur Sullu, Department of Pathology, Faculty of Medicine, Ondokuz Mayıs University, Kurupelit, Samsun, 55139 TurkeyIdris Yucel, Department of Medical Oncology, Faculty of Medicine, Ondokuz Mayıs University, Kurupelit, Samsun, 55139 Turkey Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5260250 Sun, 25 Sep 2011 05:37:08 +0100 5260250 http://www.medworm.com/index.php?rid=5260251&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft4022145kx2137t1%2F In conclusion, the GEMOX regimen is well tolerated and effective in advanced differentiated thyroid cancer. However, this retrospective data on a small sample size are considered preliminary and needs to be evaluated prospectively in a higher number of patients in a clinical trial. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s12032-011-0070-2Authors Jean-Philippe Spano, Medical Oncology Department, GH Pitié-Salpêtrière, Université Paris 6, Paris, FranceY. Vano, Medical Oncology Department, GH Pitié-Salpêtrière, Université Paris 6, Paris, FranceS. Vignot, Medical Oncology Department, GH Pitié-Salpêtrière, Université Paris 6, Paris, FranceT. De La Motte Rouge, Medical Oncology Department, GH Pitié-Salpêtrière, Université Paris 6, Paris, Fr... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5260251 Sun, 25 Sep 2011 05:37:07 +0100 5260251 http://www.medworm.com/index.php?rid=5260252&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk35116p035524n77%2F Abstract  The aim of this study is to elucidate the prognostic significance of thymidylate synthase (TS), orotate phosphoribosyltransferase (OPRT) and dihydropyrimidine dehydrogenase (DPD) in completely resected non-small cell lung cancer (NSCLC). One hundred and sixty patients with NSCLC were included in this study. Tumor sections were stained by immunohistochemistry for TS, OPRT, DPD, glucose transporter 1 (Glut1), hypoxia inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF), microvessel density (MVD) determinated by CD34, epidermal growth factor receptor (EGFR), phosph-Akt, phosph-mammalian target of rapamycin (mTOR) and p53. TS, OPRT and DPD were positively expressed in 46, 71 and 54%, respectively. The expression of TS and OPRT was significantly hi... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5260252 Fri, 23 Sep 2011 16:19:40 +0100 5260252 http://www.medworm.com/index.php?rid=5260254&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh1ng4q1746528256%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12032-011-0072-0Authors Maciej Machaczka, Division of Hematology, Department of Medicine at Huddinge, Karolinska Institute, and Hematology Center Karolinska, M54, Karolinska University Hospital Huddinge, Stockholm, Sweden Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5260254 Fri, 23 Sep 2011 05:54:30 +0100 5260254 http://www.medworm.com/index.php?rid=5260253&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh64j1582w52p0450%2F Abstract  Angiogenesis is the new blood vessels formation and is the critical event for the growth of malignant diseases and plays a key role in the development, invasion, and metastasis of malignant tumors. Epstein-Barr virus (EBV) is an important carcinogen causing to the some neoplastic disorders and lytically infected cells may contribute to the growth of EBV-associated malignancies, and this phenomenon is related with enhancing angiogenesis. Due to the strong cross-talk between angiogenesis and viral carcinogenesis and increased information about the angiogenesis and viral carcinogenesis in lymphomas, we need new therapeutic approaches to cases with lymphoma. Due to the strong cross-talk between angiogenesis and viral lymphomagenesis, this association was reviewed in t... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5260253 Fri, 23 Sep 2011 05:54:30 +0100 5260253 http://www.medworm.com/index.php?rid=5236879&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F05952347m0306248%2F The objective response rate of was 42.64% in the VC-APS arm and 36.76% in the VC arm. The difference was not statistically significant (P = 0.483). Median survival time was 10.7 and 10.2 months (P = 0.76) in VC-APS arm and VC arm, with 1-year survival rates of 35.3 and 32.4% (P = 0.717), respectively. After 3 cycles of treatment, there were significant differences in the overall patient QOL (P = 0.003), physical function (P = 0.01), fatigue (P < 0.001), nausea and vomiting (P < 0.001), pain (P = 0.007), and loss of appetite (P = 0.023) between the two study groups. In summary, we have proved that the treatment of APS integrated with VC had significantly improved QOL in patients with ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5236879 Sat, 17 Sep 2011 17:06:54 +0100 5236879 http://www.medworm.com/index.php?rid=5236880&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjr02620q326540x0%2F Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s12032-011-0064-0Authors Mark Lazarus, Rush Medical College, Rush University, Chicago, IL, USAHoward Kaufman, Department of Surgical Oncology, Faculty of Medicine, Rush University, Chicago, IL, USA Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5236880 Fri, 16 Sep 2011 05:45:15 +0100 5236880 http://www.medworm.com/index.php?rid=5236881&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F280k57u175885nt5%2F In this study, we evaluated the prognostic relevance of MMP9 expression and EBV status in HRS cells in patients with cHL in Brazil. We selected 97 patients with cHL for EBV and MMP9 detection. EBV was detected in 52.5%, and MMP9 expression positivity was found in 87.6%. Of all cases, there was no correlation between MMP9 expression and EBV status. Response to treatment and relapse rate was independent of MMP9 expression and EBV status. MMP9 positivity did not influence overall survival and event-free survival. The consistent and increased intensity of MMP9 expression in HRS cells make this enzyme a potential target for therapy. Content Type Journal ArticleCategory Short CommunicationPages 1-5DOI 10.1007/s12032-011-0063-1Authors Eni M. Souza, Departamento de Oncologia Clínica e... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5236881 Fri, 16 Sep 2011 05:45:14 +0100 5236881 http://www.medworm.com/index.php?rid=5236882&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc26664435276m815%2F In conclusion, this study provided clinical evidence that loss of Bad is an independent and powerful predictor of adverse prognosis in NSCLC. Bad protein could be a new biomarker for selecting individual therapy strategies and predicting therapeutic response in subjects with NSCLC. Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s12032-011-0060-4Authors Yi Huang, Laboratory of Genetic Disease and Perinatal Medicine, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of ChinaDan Liu, Department of Respiratory Medicine, West China Hospital, Sichuan University, 610041 Chengdu, People’s Republic of ChinaBojiang Chen, Department of Respiratory Medicine, West China Hospital, Sichuan University, 610041 Chengdu, People’s Rep... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5236882 Thu, 15 Sep 2011 05:49:20 +0100 5236882 http://www.medworm.com/index.php?rid=5224974&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn69k1237l4731008%2F Abstract  S100A11 is a member of S100 protein family, and our previous study showed that S100A11 is one of the up-regulated proteins that have not been reported to be associated with pancreatic carcinoma. The purpose of this study was to investigate the relation between S100A11 expression and the clinicopathological variables and clinical outcome in patients with pancreatic adenocarcinoma. Immunohistochemistry analysis was performed for S100A11 in 78 pairs of specimens of human pancreatic adenocarcinoma tissues and adjacent nontumorous tissues. The univariate and multivariate survival analyses were also performed to determine its prognostic significance. S100A11 expression in pancreatic adenocarcinoma (62/78) was significantly higher than that in the adjacent nontumorous ti... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5224974 Tue, 13 Sep 2011 05:48:51 +0100 5224974 http://www.medworm.com/index.php?rid=5224976&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8160568723836x38%2F Abstract  The aim of this study was to evaluate the expression of Y-box binding protein-1 (YB-1) in nonneoplastic cervical tissue and cervical cancer tissue and to evaluate its relationship with chemoradiosensitivity in the cases of cervical cancer. We performed immunohistochemical studies to examine YB-1 expression among 59 patients with cervical cancer, 30 with cervical intraepithelial neoplasia (CIN), and 30 with cervicitis. The mean YB-1 histological score(HSCORE)values for cervicitis, cervical CIN, and cervical cancer tissues were 22.3, 39, and 84.4, respectively. The mean YB-1 HSCORE value was 80.0 for cervical cancer patients who showed complete pathological response to chemoradiotherapy and 144.3 for cervical cancer patients who showed partial pathological response.... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5224976 Sat, 10 Sep 2011 15:46:35 +0100 5224976 http://www.medworm.com/index.php?rid=5224975&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F083431467kt9t8g0%2F Abstract  The role of human papillomavirus (HPV) in breast cancer is controversial. We evaluated 118 breast carcinomas and two paraffin-embedded tissues of lesions of the nipple of Mexican patients for HPV sequences. No carcinoma sample exhibited koilocytosis, in contrast to lesions of the nipple. We subjected purified DNAs to PCR employing two HPV16/E6 or GP5/6 primer set oligonucleotides. Results showed that HPV DNA sequences were absent in the breast tissues. Absence of HPV in breast carcinoma failed to support an association between HPV infection and this carcinoma. Content Type Journal ArticleCategory Short CommunicationPages 1-3DOI 10.1007/s12032-011-0059-xAuthors Lisbeth Herrera-Romano, División de Investigación en Salud, Unidad Médica de Alta Especialidad (U... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5224975 Sat, 10 Sep 2011 15:46:35 +0100 5224975 http://www.medworm.com/index.php?rid=5224977&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy01jp000pl450333%2F We examined the Nedd4L expression in 82 gastric cancer patients by immunohistochemistry. The correlation between Nedd4L expression and clinicopathological factors, including prognosis, was evaluated. Cancerous Nedd4L expression was detectable in 36 of the 82 tumors (43.9%). Tumors with negative Nedd4L expression had greater extent of lymph node metastasis, lymphatic invasion, and venous invasion, and were at a worse stage than the tumors with positive Nedd4L expression. Additionally, the patients with negative Nedd4L expression had poor clinical outcomes. Furthermore, multivariate analysis indicated that Nedd4L expression was an independent prognostic factor for gastric cancer patients. Our results suggest for the first time that negative Nedd4L expression is strongly related to the ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5224977 Sat, 10 Sep 2011 15:46:34 +0100 5224977 http://www.medworm.com/index.php?rid=5208079&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd1555r310h118236%2F In conclusion, the present study indicates that the GPX1 Pro198Leu polymorphism may be associated with the risk and development of invasive bladder cancer. In addition, the combination of the MnSOD Ala/Ala and GPX1 Leu/Leu genotypes may have a synergistic effect on disease risk. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s12032-011-0057-zAuthors Canan Kucukgergin, Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, TurkeyOner Sanli, Department of Urology, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, TurkeyAkın S. Amasyalı, Department of Urology, Istanbul Teaching and Research Hospital, 34098 Istanbul, TurkeyTzevat Tefik, Department of Urology, Istanbul Faculty of Medicine, Istanbul Uni... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5208079 Fri, 09 Sep 2011 05:49:20 +0100 5208079 http://www.medworm.com/index.php?rid=5208080&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flt30l0p7x5575403%2F Abstract  Approximately 10% of colorectal carcinomas demonstrate microsatellite instability (MSI). Distinct from the majority of colorectal cancers with chromosomal instability (CIN) which harbour allelic imbalance from chromosomal polyploidy and aneuploidy, MSI tumours retain intact chromosomal numbers but contain microsatellite repeats due to deficiency in mismatch repair which are thought to contribute to the early steps of tumourigenesis in colorectal cancer. While emerging clinical data has highlighted improved prognosis of tumours with MSI in early colorectal cancer and potentially circumventing the need for adjuvant chemotherapy, the implications of MSI deficiency in metastatic colorectal cancer (mCRC) remain uncertain. In order to assess the significance of MSI in m... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5208080 Thu, 08 Sep 2011 05:55:29 +0100 5208080 http://www.medworm.com/index.php?rid=5208081&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn442r2010r414243%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s12032-011-0055-1Authors Silvio Altarac, Department of Surgery and Urology, Zabok General Hospital, Bračak 8, 49210 Zabok, CroatiaDino Papeš, Department of Surgery and Urology, Zabok General Hospital, Bračak 8, 49210 Zabok, Croatia Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5208081 Sun, 04 Sep 2011 10:57:03 +0100 5208081 http://www.medworm.com/index.php?rid=5183480&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fppn0mw6443mg105l%2F Abstract  To determine whether prognostic factors remain relevant to chronic lymphocytic leukemia (CLL) patients treated with fludarabine and cyclophosphamide (FC), we prospectively evaluated 86 Chinese CLL patients who received FC in first-line therapy. Twenty-four patients (27.9%) achieved complete remission (CR), and overall response rate was 75.6%. With a median follow-up of 41 months, the median progression-free survival (PFS) was 36.0 months and median overall survival (OS) has not been reached. The strong correlations of lower CR rate with advanced Binet stage, unmutated IGHV, cytogenetic abnormalities of del(17p13) or del(11q23), and p53 mutations were observed by univariable analyses. Stepwise logistic regression identified that unmutated IGHV and p53 abn... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5183480 Wed, 31 Aug 2011 15:54:07 +0100 5183480 http://www.medworm.com/index.php?rid=5183481&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3442827036534553%2F Abstract  Leptin is a well-known mediator of obesity. Leptin and its receptor are overexpressed in breast cancer, especially in high-grade tumors. It has an association with progression and poor survival of breast cancer. Leptin can regulate endothelial cell proliferation and promote angiogenesis. There are several other factors such as insulin and HER2 may be involved in the relationship between leptin and breast cancer. Leptin system has emerged as a new and promising therapeutic target for breast cancer. This review article summarizes the current knowledge about the relation of leptin and breast cancer. Content Type Journal ArticleCategory Review ArticlePages 1-5DOI 10.1007/s12032-011-0056-0Authors Mehmet Artac, Division of Medical Oncology, Selcuk University Meram ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5183481 Tue, 30 Aug 2011 05:41:50 +0100 5183481 http://www.medworm.com/index.php?rid=5183482&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp2m65528568k3803%2F Abstract  The present study examines the clinical significance of serum neuron-specific enolase (NSE) in patients with non-germinal center B-cell type (non-GCB) of diffuse large B-cell lymphoma (DLBCL) that received rituximab chemotherapy. Serum NSE values were measured using electrochemiluminescence assay in 53 patients. About 54.7% of the DLBCL patients had positive expression of serum NSE (>15.20 ng/ml), which closely correlated with performance status, serum LDH level, B symptoms, IPI scores, and Ann-Arbor stages (P < 0.05). The mean serum NSE value in patients with non-GCB subtype of DLBCL was significantly higher than that of GCB subtype of DLBCL (P = 0.001), and among patients in non-GCB subtype group, there was significant difference in... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5183482 Mon, 29 Aug 2011 16:00:01 +0100 5183482 http://www.medworm.com/index.php?rid=5183483&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg38l8853541wx1m6%2F Abstract  Cancerous inhibitor of protein phosphatase 2A (CIP2A) and survivin are aberrantly expressed in a wide range of human cancers, including lung tumors. In order to assess the expressions of these two proteins in Chinese non-small-cell lung cancer (NSCLC) patients and determine their correlation with prognosis, NSCLC tissues and adjacent non-cancerous normal lung tissues were collected from 97 patients undergoing surgical treatment and evaluated by immunohistochemistry staining. CIP2A or survivin immunoreactivity was detected in significantly more NSCLC tissues than in adjacent non-cancerous lung tissues (P < 0.05). Moreover, CIP2A expression in NSCLC correlated with TNM stage, while survivin expression correlated with TNM stage and lymph node metastasis. ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5183483 Sun, 28 Aug 2011 05:36:25 +0100 5183483 http://www.medworm.com/index.php?rid=5175533&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx3843791t850740x%2F Abstract  As a main effector in the renin-angiotensin system, the angiotensin II plays a critical role in cell proliferation and angiogenesis. The change between angiotensin II and its precursor is conducted by the angiotensin-converting enzyme. The association between angiotensin-converting enzyme insertion/deletion polymorphism and the activity of angiotensin-converting enzyme was testified. Furthermore, previous researches proved the association between angiotensin-converting enzyme activity and the risk of prostate cancer. Therefore, we conducted a case–control study in the Han population of China to elaborate the relation between the angiotensin-converting enzyme insertion/deletion polymorphism and prostate cancer. DNA was extracted from blood samples collected from ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5175533 Sat, 27 Aug 2011 15:48:30 +0100 5175533 http://www.medworm.com/index.php?rid=5175534&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm1262652l0790581%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-1DOI 10.1007/s12032-011-0052-4Authors Yasemin Savranlar, Department of Histology and Embryology, Faculty of Medicine, Erciyes University, 38039 Kayseri, TurkeyMehmet Fatih Sönmez, Department of Histology and Embryology, Faculty of Medicine, Erciyes University, 38039 Kayseri, Turkey Journal Medical OncologyOnline ISSN 1559-131XPrint ISSN 1357-0560 (Source: Medical Oncology) Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5175534 Sat, 27 Aug 2011 15:48:28 +0100 5175534 http://www.medworm.com/index.php?rid=5161205&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu42p60u438400845%2F Abstract  Nucleoporin88 (Nup88) has been shown to be overexpressed in a wide variety of malignancies including colorectal cancer (CRC). However, no study about serum Nup88 in human CRC was reported. Therefore, in this study, we investigated the level of serum Nup88 protein and its relationships with clinicopathological variables in CRC. The serum concentration of Nup88 protein was determined by a quantitative sandwich enzyme-linked immunosorbent assay (ELISA) in 118 pre-operative serum samples, 66 post-operative and 96 healthy controls. Among the patients, the levels of CEA (n = 91) and CA19-9 (n = 87) in the pre-operative serum were measured, and DNA sequencing was performed in 12 CRCs and 2 samples from non-cancerous colon tissue. In the same patients, ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5161205 Wed, 24 Aug 2011 07:18:40 +0100 5161205 http://www.medworm.com/index.php?rid=5161206&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa3570127237t5961%2F In this study, we analyzed the correlation between expression of PGP and lymphoid antigens (Ly) on leukemic myeloblasts versus response to therapy and survival in acute myeloid leukemia (AML). Fifty-one consecutive patients, aged 16–75 (median age 44.6 years), diagnosed with de novo AML between 1997 and 2000, and who received at least one induction chemotherapy course, were enrolled in the study. Expression of PGP on ≥10% of the myeloblasts (PGP+AML) at the time of diagnosis was observed in 21 patients (41%). The complete remission rate did not differ between PGP+ (13/21) and PGP− (20/30) patients (62 vs. 67%). Twelve of the 51 patients (24%) were still alive after a median follow-up time of 11.5 years (range 10.7–13.1). The Ly+AML patients showed significantly better... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5161206 Tue, 23 Aug 2011 05:57:12 +0100 5161206 http://www.medworm.com/index.php?rid=5161207&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh63375477p784232%2F Abstract  The present study was aimed at evaluating the expression of heat shock protein 27 (HSP27) and heterogeneous nuclear ribonucleoprotein K (hnRNP K), two potential biomarkers of many cancers, in colorectal cancer (CRC) and their clinical significance. Expression of HSP27 and hnRNP K were investigated by immunohistochemistry (IHC) in a series of tissue microarrays containing 175 primary colorectal cancers and their corresponding normal mucosa samples and matched with clinicopathological features and patient survival. HSP27 and hnRNP K displayed more frequent strong immunoreactivity in primary colorectal tumor samples compared with adjacent non-cancer tissue (P < 0.001). Increased cytoplasmic expression of HSP27 and hnRNP K were associated with tumor locati... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5161207 Tue, 23 Aug 2011 05:57:11 +0100 5161207 http://www.medworm.com/index.php?rid=5161208&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5653253471qg121v%2F Abstract  Prostate epithelial and stromal cells develop paracrine interactions, which may be responsible for the occurrence and progression of prostate pathologies. Strikingly, stromal cells exhibit pleiotropic effects on epithelial cell growth, ranging from stimulation to inhibition. Steroid hormone receptors are considered ligand-activated transcriptional factors. Moreover, it has been suggested that the human androgen receptor can also be activated in the absence of surrounding ligands such as growth factors and cytokines. Strong evidence suggests that cytokines may play an important role in ligand-independent activation of androgen receptor in prostate cancer cells. In our view, one of the most striking finding in the prostate cancer development process is the relationsh... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5161208 Sat, 20 Aug 2011 05:41:41 +0100 5161208 http://www.medworm.com/index.php?rid=5161209&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc1j01m0511kvju1m%2F Abstract  To investigate the sequential use of two tyrosine-kinase inhibitors (TKI), sorafenib (SOR) and sunitinib (SUN), in advanced renal carcinoma. We retrospectively analyzed the clinical outcome of 33 patients who had experienced progression or unacceptable toxicity after receiving either sorafenib or sunitinib and then switched to the other reciprocal agent. Progression-free survival (PFS) during the first TKI was similar regardless of drug with a median of 6 months in the SOR-SUN group (n = 15) and 7.5 months in the SUN-SOR group (n = 18). Interestingly, PFS during the second TKI was significantly longer in the SOR-SUN group as compared to the SUN-SOR group with median values of 11 and 3 months, respectively (P = 0.0377; HR ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5161209 Fri, 19 Aug 2011 15:53:33 +0100 5161209 http://www.medworm.com/index.php?rid=5161210&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg52rj98161m366n7%2F Abstract  Tiam1–Rac1 signaling plays an important role in the migration, invasion and metastasis of tumor cells. The aim of the present study was to clarify the clinical value of Tiam1 and Rac1 expression in primary gallbladder carcinoma (PGC). Eighty-six PGC tissues were evaluated by immunohistochemistry for Tiam1 and Rac1 expression. The association of Tiam1 and Rac1 expression with clinicopathological characteristics and the univariate survival analysis for the influence of Tiam1 and Rac1 expression on the overall survival were analyzed. Tiam1 and Rac1 immunoreactivities were observed in 72 (83.7%) and 68 (79.1%) of the 86 PGC cases, but not in the non-neoplastic gallbladder tissues, respectively. The tumors with the positive expression of Tiam1 and Rac1 more frequentl... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5161210 Fri, 19 Aug 2011 06:41:29 +0100 5161210 http://www.medworm.com/index.php?rid=5161212&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp8427h521206h603%2F Abstract  Survival in patients with advanced non-small-cell lung cancer (NSCLC) has substantially improved. Long-term chemotherapy with epidermal growth factor tyrosine kinase inhibitors (EGFR-TKIs) and other agents has been associated with long survival. We retrospectively examined the associations between overall survival (OS) and clinical variables in patients with advanced NSCLC who received at least one dose or course of outpatient chemotherapy in our institution. Of 360 patients who received first-line chemotherapy between January 1, 2004 and December 31, 2007, 185 subsequently received additional outpatient chemotherapy and 175 underwent inpatient chemotherapy only. Of the 185 patients, 147 (79.5%), 96 (51.9%), and 60 (32.4%) received second-line, third-line, and fou... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5161212 Fri, 19 Aug 2011 06:41:28 +0100 5161212 http://www.medworm.com/index.php?rid=5161211&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy50h04362448h177%2F This study highlights the combination of inflammatory CRP levels, Hb levels, and WBC count as the most important independent prognostic factor in predicting disease recurrence of patients with OSCC. LPI can be used as a pre-treatment inflammatory biomarker that may identify OSCC with a more aggressive biological phenotype of the disease and might be helpful for guiding further post-operative treatment in OSCC. Content Type Journal ArticleCategory Original PaperPages 1-13DOI 10.1007/s12032-011-0045-3Authors M. Grimm, Department of Oral and Maxillofacial Surgery, Plastic Operations, General Hospital, Breslauer Strasse 201, 90471 Nuremberg, GermanyM. Lazariotou, Department of Cardiac and Thoracic Surgery, University of Wuerzburg Hospital, Oberduerrbacher Strasse 6, 97080 Wuerzburg,... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5161211 Fri, 19 Aug 2011 06:41:28 +0100 5161211 http://www.medworm.com/index.php?rid=5161213&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F75847m82n24546q8%2F Abstract  To study the treatment outcomes of brain-only metastases from small-cell lung cancer (SCLC) at initial diagnose treated by chemotherapy with concurrent brain and thoracic radiotherapy (RT). From Jan 2004 to Jan 2009, 36 treatment-naïve SCLC patients with brain-only metastases in Sun yat-sen University were enrolled. Treatment contained initial EP chemotherapy with concurrent whole-brain radiotherapy (WBRT). EP regimen consisted of etoposide 100 mg/m2 IV d1-3, cisplatin 80 mg/m2 IV d1, repeated every 3 weeks. WBRT with total dose of 30 Gy in 10 fractions was started within 1 week from the beginning of chemotherapy followed by thoracic RT including 2 Gy once daily to a total dose of 60 Gy. Treatment responses were evaluated after 3... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5161213 Fri, 19 Aug 2011 06:41:27 +0100 5161213 http://www.medworm.com/index.php?rid=5161214&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fuk8727003207860x%2F Abstract  ATM protein kinase plays a critical role in maintaining genome integrity by activating a biochemical chain reaction that in turn leads to cell cycle checkpoint activation and repair of DNA damage. Cyclin D1 acts in regulating the G1 phase of the cell cycle. Experimental and clinical studies suggest them to be involved in transformation and tumour progression. To elucidate the role of ATM and cyclin D1 expression in sporadic breast cancer, we investigated the possible link between their RNA expression levels in ductal carcinoma and normal adjacent versus normal breast tissues measured by Taqman real-time PCR in 119 breast tissues. Results showed that cyclin D1 over-expressed in 51.4% of breast tumours, whereas ATM expression was down regulated in 55% of breast tumo... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5161214 Thu, 18 Aug 2011 06:01:11 +0100 5161214 http://www.medworm.com/index.php?rid=5161215&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft80685u8018r5047%2F Abstract  Programmed cell death 4 (PDCD4) is a tumor suppressor that can inhibit tumorigenesis by suppressing activator protein (AP)-1 activation and protein translation. Lost or decreased PDCD4 expression has been found in multiple types of human cancers, which was also associated with progression and metastasis of the tumors. However, the status and significance of PDCD4 in gastrointestinal stromal tumors have not been evaluated. In the present study, we examined the PDCD4 expression in a total of 63 gastrointestinal stromal tumor samples at both mRNA and protein levels by RT-PCR, western blot, and immunohistochemistry. We demonstrated that the expression of PDCD4 mRNA was diminished in 68% (17/25) of the tumor samples, and the level of PDCD4 protein appeared to be decrea... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5161215 Thu, 18 Aug 2011 06:01:09 +0100 5161215 http://www.medworm.com/index.php?rid=5143406&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F32k55033651t42k4%2F Abstract  Panitumumab is the first fully human monoclonal antibody targeting the epidermal growth factor receptor whose clinical use is limited to patients with a non-mutated KRAS status. The aim of this in vitro study was to evaluate whether the KRAS status might influence the cytotoxic and radiosensitizing efficacy of Panitumumab. Exponentially growing cancer cells (HT-29: KRAS wild-type, A549: KRAS mutant) were either treated with the monoclonal antibody alone in growth and proliferation assays or in combination with radiation in metabolic and colony-forming assays. For the assessment of ionizing radiation-induced DNA damage and to evaluate Panitumumab’s influence on DNA damage repair, the γH2AX foci assay was performed. Treatment with Panitumumab resulted in a concent... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5143406 Sun, 14 Aug 2011 05:43:56 +0100 5143406 http://www.medworm.com/index.php?rid=5131797&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F04006743q4254m84%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s12032-011-0039-1Authors A. Daraei, Department of Biomedical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranR. Salehi, Department of Biomedical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranM. Salehi, Department of Biomedical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranM. H. Emami, Isfahan University of Medical Sciences, Isfahan, IranM. Janghorbani, Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, IranF. Mohamadhashem, Department of Biomedical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranH. Tavakoli, Isfahan University o... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5131797 Fri, 12 Aug 2011 06:17:46 +0100 5131797 http://www.medworm.com/index.php?rid=5126133&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F34t128374333tr63%2F Abstract  Both narrow band imaging (NBI) and autofluorescence imaging (AFI) are new techniques for the assessment of lung cancer. The major aim of this study was to investigate whether the combination of these two techniques improve sensitivity and specificity in the assessment of lung cancer extension. The study prospectively evaluated 118 patients with suspected lung cancer. All of the patients were examined using EVIS LUCERA SPECTRUM videobronchoscopy system. The narrow band imaging preceded autofluorescence imaging examination. In every patient, at least 1 but no more than 4 biopsies were taken from places visualized as pathologic, surrounding primary tumor, and at least 1 biopsy from places that appeared visually normal. Sensitivity, specificity, positive, and negative... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5126133 Mon, 08 Aug 2011 19:55:34 +0100 5126133 http://www.medworm.com/index.php?rid=5109073&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv44317477q83uw46%2F Abstract  US Oncology Research Trial 9735 reported that TC improved overall survival when compared to doxorubicin and cyclophosphamide in early-stage breast cancer. Despite 61% grades 3–4 neutropenia in the TC arm, only 5% of patients developed febrile neutropenia (FN) without primary prophylactic GCSF (ppGCSF). TC has risen in popularity, particularly in older patients or in those where an anthracycline is contraindicated. Other studies examining the toxicity of TC without ppGCSF reported a higher incidence of FN between 23 and 46%. We reviewed our institutional experience with ppGCSF and the TC regimen. Women treated with adjuvant TC and pegfilgrastim at Roswell Park Cancer Institute were identified from the pharmacy database between 8/2006 and 11/2010. Patient characte... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5109073 Fri, 05 Aug 2011 06:01:45 +0100 5109073 http://www.medworm.com/index.php?rid=5097202&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1g4512865w682244%2F Abstract  Rituximab (the chimeric anti-CD20 antibody) is widely used in the treatment of CD20 positive non-Hodgkin’s lymphoma (NHL). The response rate at relapse after repeated use in prior CD20 positive responders is lower than 50%. Several mechanisms can be responsible for rituximab resistance. CD20 negative relapses which transformed from CD20 positive aggressive and indolent forms of lymphoma can be the one of the reason of secondary resistance to rituximab. The authors report a case with combination of aggressive and indolent form of lymphoma who relapsed after 7 months from the last dose of rituximab therapy. CD20 transformed negative from positive in her relapsed disease. Patients with CD20 positive B cell NHL must rebiopsy after first line rituximab therapy i... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5097202 Sun, 31 Jul 2011 05:40:52 +0100 5097202 http://www.medworm.com/index.php?rid=5097203&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy8207171022t6288%2F This study aimed to investigate association between single-nucleotide polymorphisms (SNPs) of excision repair cross-complementing gene 1 (ERCC1), excision repair cross-complementing gene 2 (ERCC2), and X-ray repair cross-complementing group 1 (XRCC1) with sensitivity of advanced non-small cell lung cancer (NSCLC) patients to platinum-based chemotherapy. A total of 89 NSCLC patients were recruited and treated with two cycles of platinum-based chemotherapy. DNA was extracted from peripheral lymphocytes for detection of SNPs of ERCC1 Asn118Asn, ERCC2 Lys751Gln, and XRCC1 Arg399Gln. The overall response rate of these patients was 29.2%. There was no statistically significant difference of treatment response between the wild genotypes and the variant genotypes for the ERCC1 Asn118Asn and ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5097203 Sun, 31 Jul 2011 05:40:51 +0100 5097203 http://www.medworm.com/index.php?rid=5063448&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg215572x44568v17%2F Abstract  Many recent studies have shown the utility of microRNAs (miRs) as cancer-related biomarkers. The aim of the present study was to evaluate the correlation between miR-203 expression and prognosis of patients with hepatocellular carcinoma (HCC) and cirrhosis after liver transplantation (LT). Sixty-six HCC samples from patients who had undergone LT were examined for miR-203 expression using quantitative reverse transcription–polymerase chain reaction. The data were correlated with clinicopathological parameters and prognosis. Patient survival was analyzed by the Kaplan–Meier method and log-rank test. Cox regression was used for multivariate analysis of prognostic factors. We found that miR-203 expression was low in tumor tissues of patients (n = 16) with... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5063448 Sat, 23 Jul 2011 15:49:49 +0100 5063448 http://www.medworm.com/index.php?rid=5063449&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F020027w48p9758pg%2F Abstract  Tissue inhibitors of metalloproteinases (TIMPs) play an important role in extracellular matrix homeostasis by regulating MMP activity. Although they were initially considered inhibitors of tumor growth and metastasis, recently their role in cancer progression has been controversial. The aim of our study was to compare the immunohistochemical expression of TIMP1 and TIMP2 between an uncontrollably invasive phenomenon (cancer) and an “in situ” process (trophoblast invasion) in an effort to assess any differential role of these molecules between these two distinct phenomena and therefore to understand better their contribution in cancer invasion and migration. We performed an immunohistochemical analysis of 50 carcinomas (colorectal, gastric, breast, pulmonary, a... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5063449 Sat, 23 Jul 2011 15:49:48 +0100 5063449 http://www.medworm.com/index.php?rid=5063450&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh36055418664hql0%2F Abstract  Epidermal growth factor receptor (EGFR) was expressed widely in NPC. The aim of this study was to investigate the difference of expression of EGFR and Ki67 in primary and recurrence of NPC to supply a micro-evidence of anti-EGFR targeted maintenance therapy for NPC. A retrospective review of 40 patients with clinical stages I–IV b was performed. Chemoradiation was included chemotherapy with fluorouracil plus cisplatin and irradiation for primary and lymph draining regions. All patients were verified tumor locoregional relapse with/or without distant metastasis by CT or MRI after combined CRT by primary and recurrence biopsies. The correlation between EGFR and Ki67 expression inspected by immunohistochemistry was analyzed. The difference of time to recurrence gro... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5063450 Fri, 22 Jul 2011 17:07:36 +0100 5063450 http://www.medworm.com/index.php?rid=5063452&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1672667483273564%2F This study aimed to devise a prognostic model specifically for extranodal NK/T-cell lymphoma, providing risk stratification in affected patients. A total of 146 patients newly diagnosed with extranodal NK/T-cell lymphoma were retrospectively analyzed. Independent predictors of survival were determined by Cox regression analysis. The estimated 5-year overall survival rate for all patients was 41.9%. Both the International Prognostic Index and Korean NK/T-cell lymphoma Prognostic Index were prognostic in univariate analysis. The majority of our patients were in the low-risk International Prognostic Index and Korean NK/T-cell lymphoma Prognostic Index category (with no or one adverse factor), but both of these two prognostic models had no discriminating power within the subgroup of the... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5063452 Fri, 22 Jul 2011 17:07:35 +0100 5063452 http://www.medworm.com/index.php?rid=5063451&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F97287116v02g6n76%2F Abstract  Tumor-associated glycoprotein-72 (TAG-72) is a high molecular weight tumor-associated glycoprotein, which is known to be overexpressed in various human tumors, but its expression in glioma tissues is unknown. Therefore, the aim of this study was to investigate whether TAG-72 is present in glioma and to evaluate the correlation between TAG-72 expression and the severity of the malignancy of this tumor. Immunohistochemistry and Western blot were used to investigate the expression of TAG-72 protein, respectively, in 152 patients with gliomas. There were 90 men and 62 women (mean age 50.6 ± 11.8 years). Astrocytoma was found in 130 patients and glioblastoma in 22. No TAG-72 expression was found in the non-cancerous brain tissues. TAG-72 protein expressi... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5063451 Fri, 22 Jul 2011 17:07:35 +0100 5063451 http://www.medworm.com/index.php?rid=5063454&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd79k8761153630t4%2F Abstract  A study of patients with advanced non-squamous non-small cell lung cancer (NSCLC) evaluated epidermal growth factor receptor (EGFR) mutation status and serum hepatocyte growth factor (HGF) for their associations with response to gefitinib therapy and prognostic impact. An enzyme-linked immunosorbent assay was used to determine levels of HGF in serum from 96 Japanese patients with advanced non-squamous NSCLC. The peptic nucleic acid-locked nucleic acid clamp method was used to determine their EGFR somatic mutation status. We evaluated the relationship between each independent clinicopathological variable and the response to gefitinib therapy and risk factors associated with prognosis. HGF-positive serum status (hazard ratio, 1.536; 95% confidence interval, 1.042–... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5063454 Thu, 21 Jul 2011 18:08:10 +0100 5063454 http://www.medworm.com/index.php?rid=5063453&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm6816h4u3485r805%2F In conclusion, we demonstrate a significant importance of the number of reinfused CD34+ cells on the time to platelet recovery. Content Type Journal ArticlePages 1-9DOI 10.1007/s12032-011-0029-3Authors J. S. Ungerstedt, Hematology Center, Karolinska University Hospital, R51, S-14186 Stockholm, SwedenE. Watz, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, SwedenK. Uttervall, Hematology Center, Karolinska University Hospital, R51, S-14186 Stockholm, SwedenB-M Johansson, Department of Clinical Immunology & Transfusion Medicine, Karolinska University Hospital, Stockholm, SwedenB. E. Wahlin, Hematology Center, Karolinska University Hospital, R51, S-14186 Stockholm, SwedenP. Näsman, Center for Safety Research, Royal Institut... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5063453 Thu, 21 Jul 2011 18:08:10 +0100 5063453 http://www.medworm.com/index.php?rid=5063455&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm62601272616pv25%2F Abstract  Arsenic trioxide (ATO) has shown anticancer activity against a variety of solid tumor models through induction of apoptosis, promotion of cellular differentiation, and inhibition of cellular invasive ability. The present study investigated the role of ceramide in regulating the invasive activity of hepatoma carcinoma HCCLM3 cells during ATO treatment. We found that ATO treatment inhibited HCCLM3 cell invasion and downregulated matrix metalloproteinase-9 (MMP-9) protein levels in a concentration-dependent manner. ATO also dose dependently induced the generation and accumulation of ceramide in HCCLM3 cells. Blockage of intracellular ceramide production through the inhibition of de novo ceramide synthesis or the hydrolysis of sphingomyelin increased the invasive abil... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5063455 Tue, 19 Jul 2011 23:23:41 +0100 5063455 http://www.medworm.com/index.php?rid=5052455&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb88u26713m45555m%2F Abstract  Cell surface transmembrane signaling receptors EGFR, HER3, and HER4 are activated by ligand-binding-mediated dimerization and phosphorylation. In contrast, HER2 amplification promotes signaling by increasing homo/heterodimerization and ligand binding. Trastuzumab or lapatinib therapy of HER2 amplicon-positive breast cancer cells induces growth inhibition and intracellular growth pathway signaling modulation. The mechanism(s) by which trastuzumab, an IgG1 humanized antibody, induces modification of cell signaling upon binding to an extracellular determinant on a ligand-less “receptor” membrane protein remains unexplained. Using immune detection methodology comprised of antibodies detecting three distinct domains of HER and five tyrosine/threonine phosphorylatio... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5052455 Mon, 18 Jul 2011 15:53:46 +0100 5052455 http://www.medworm.com/index.php?rid=5038113&cid=s_35998_6_f&fid=35998&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu11271u3236531k8%2F Abstract  Homeostasis-driven proliferation of T cells is an important means of reconstituting T-cell-dependent immunity after lymphodepletion regimens, such as chemotherapy or radiotherapy. Immune-reconstituted mice that receive a tumor vaccine mount more efficient anti-tumor immune responses compared with control mice. In the present study, we evaluated the anti-tumor immune responses in immune-reconstituted mice vaccinated with inactivated leukemia cells and explored the mechanisms underlying these immune responses. Test C57BL/6 mice were lymphodepleted by irradiation and immune-reconstituted with naïve mouse spleen lymphocytes. Mice were then injected with an inactivated FBL-3 tumor cell vaccine and challenged with FBL-3 tumor cells. Anti-tumor responses were evaluated ... Medical Oncology journals http://www.medworm.com/rss/comments.php?id=5038113 Fri, 15 Jul 2011 05:55:09 +0100 5038113