MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Molecular Cell' source. Sun, 21 Mar 2010 17:33:22 +0100 http://www.medworm.com/index.php?rid=3358744&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900118-8 Zuzana Jasencakova, Annette N.D. Scharf, Katrine Ask, Armelle Corpet, Axel Imhof, Geneviève Almouzni, Anja Groth. To restore chromatin on new DNA during replication, recycling of histones evicted ahead of the fork is combined with new histone deposition. The Asf1 histone chaperone, which buffers excess histon.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358744 Fri, 12 Mar 2010 04:00:17 +0100 3358744 http://www.medworm.com/index.php?rid=3358743&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900116-4 Kianoush Sadre-Bazzaz, Frank G. Whitby, Howard Robinson, Tim Formosa, Christopher P. Hill. The proteasome is an abundant protease that is critically important for numerous cellular pathways. Proteasomes are activated in vitro by three known classes of proteins/complexes, including Blm10.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358743 Fri, 12 Mar 2010 04:00:17 +0100 3358743 http://www.medworm.com/index.php?rid=3358742&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900126-7 Tomoo Ogi, Siripan Limsirichaikul, René M. Overmeer, Marcel Volker, Katsuya Takenaka, Ross Cloney, Yuka Nakazawa, Atsuko Niimi, Yoshio Miki, Nicolaas G. Jaspers, Leon H.F. Mullenders, Shunichi Yamashita, Maria I. Fousteri, Alan R. Lehmann. Nucleotide excision repair (NER) is the most versatile DNA repair system that deals with the major UV photoproducts in DNA, as well as many other DNA adducts. The early steps of NER are well under.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358742 Fri, 12 Mar 2010 04:00:17 +0100 3358742 http://www.medworm.com/index.php?rid=3358741&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900117-6 Neil M. Kad, Hong Wang, Guy G. Kennedy, David M. Warshaw, Bennett Van Houten. How DNA repair proteins sort through a genome for damage is one of the fundamental unanswered questions in this field. To address this problem, we uniquely labeled bacterial UvrA and UvrB with dif.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358741 Fri, 12 Mar 2010 04:00:17 +0100 3358741 http://www.medworm.com/index.php?rid=3358740&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900125-5 María Moriel-Carretero, Andrés Aguilera. Homologous recombination is a major double-strand break (DSB) repair mechanism that acts during the S and G2 phases. In contrast, nucleotide excision repair (NER) is a major pathway for the repair.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358740 Fri, 12 Mar 2010 04:00:17 +0100 3358740 http://www.medworm.com/index.php?rid=3358739&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900074-2 Yide Mei, Jeongsik Yong, Hongtu Liu, Yigong Shi, Judy Meinkoth, Gideon Dreyfuss, Xiaolu Yang. The specific molecular events that characterize the intrinsic apoptosis pathway have been the subject of intense research due to the pathway's fundamental role in development, homeostasis, and can.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358739 Fri, 12 Mar 2010 04:00:17 +0100 3358739 http://www.medworm.com/index.php?rid=3358738&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900154-1 Andrés Finzi, Shi-Hua Xiang, Beatriz Pacheco, Liping Wang, Jessica Haight, Aemro Kassa, Brenda Danek, Marie Pancera, Peter D. Kwong, Joseph Sodroski. The entry of human immunodeficiency virus (HIV-1) into cells is initiated by binding of the gp120 exterior envelope glycoprotein to the receptor, CD4. How does CD4 binding trigger conformational c.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358738 Fri, 12 Mar 2010 04:00:17 +0100 3358738 http://www.medworm.com/index.php?rid=3358737&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900123-1 Tom C.M. Seegar, Becca Eller, Dorothea Tzvetkova-Robev, Momchil V. Kolev, Scott C. Henderson, Dimitar B. Nikolov, William A. Barton. The Tie family of endothelial-specific receptor tyrosine kinases is essential for cell proliferation, migration, and survival during angiogenesis. Despite considerable similarity, experiments with.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358737 Fri, 12 Mar 2010 04:00:17 +0100 3358737 http://www.medworm.com/index.php?rid=3358736&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900114-0 Lijun Yan, Virginie Mieulet, Darren Burgess, Greg M. Findlay, Katherine Sully, Julia Procter, Jozef Goris, Veerle Janssens, Nick A. Morrice, Richard F. Lamb. The mammalian target of rapamycin (mTOR) pathway is activated by a variety of stimuli, including nutrients such as glucose and amino acids. The Ste20 family kinase MAP4K3 is regulated by am.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358736 Fri, 12 Mar 2010 04:00:17 +0100 3358736 http://www.medworm.com/index.php?rid=3358735&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900169-3 Jakub Godlewski, Michal O. Nowicki, Agnieszka Bronisz, Gerard Nuovo, Jeff Palatini, Michael De Lay, James Van Brocklyn, Michael C. Ostrowski, E. Antonio Chiocca, Sean E. Lawler. To sustain tumor growth, cancer cells must be able to adapt to fluctuations in energy availability. We have identified a single microRNA that controls glioma cell proliferation, migration, and res.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358735 Fri, 12 Mar 2010 04:00:17 +0100 3358735 http://www.medworm.com/index.php?rid=3358734&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900124-3 Daniele V.F. Tauriello, Andrea Haegebarth, Ineke Kuper, Mariola J. Edelmann, Marre Henraat, Marijke R. Canninga-van Dijk, Benedikt M. Kessler, Hans Clevers, Madelon M. Maurice. The mechanism by which Wnt receptors transduce signals to activate downstream β-catenin-mediated target gene transcription remains incompletely understood but involves Frizzled (Fz) receptor-media.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358734 Fri, 12 Mar 2010 04:00:17 +0100 3358734 http://www.medworm.com/index.php?rid=3358733&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900115-2 Tamás Kiss, Eléonore Fayet-Lebaron, Beáta E. Jády. Box H/ACA RNAs represent an abundant, evolutionarily conserved class of small noncoding RNAs. All H/ACA RNAs associate with a common set of proteins, and they function as ribonucleoprotein (RNP) e.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358733 Fri, 12 Mar 2010 04:00:17 +0100 3358733 http://www.medworm.com/index.php?rid=3358732&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900170-X Karina B. Falbo, Xuetong Shen. Nucleosomes are disassembled during DNA replication. How histone modifications and histone chaperones collaborate to reassemble nucleosomes on replicated DNA is explored by Jasencakova et al. (201.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358732 Fri, 12 Mar 2010 04:00:17 +0100 3358732 http://www.medworm.com/index.php?rid=3358731&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900161-9 Eleanor M. Maine. In this issue of Molecular Cell, Gent et al. (2010) describe the participation of two siRNA populations, generated by two different RNA-directed RNA polymerases, in a pathway to silence exp.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358731 Fri, 12 Mar 2010 04:00:17 +0100 3358731 http://www.medworm.com/index.php?rid=3358730&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900111-5 Bram J. van Raam, Guy S. Salvesen. Cytochrome c from mitochondria significantly accelerates the apoptotic process. In this issue of Molecular Cell, Mei et al. show that cytochrome c is itself regulated by bindi.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358730 Fri, 12 Mar 2010 04:00:17 +0100 3358730 http://www.medworm.com/index.php?rid=3358729&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900168-1 David Komander. An increasing number of cellular signaling pathways utilize protein ubiquitination for activation of signaling cascades. In this issue of Molecular Cell, Maurice and colleagues demonstrate .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3358729 Fri, 12 Mar 2010 04:00:16 +0100 3358729 http://www.medworm.com/index.php?rid=3311474&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Ffulltext%2FS1097-2765%2810%2900128-0 Kaoru Yamagata, Sally Fujiyama, Saya Ito, Takashi Ueda, Takuya Murata, Masanori Naitou, Ken-ichi Takeyama, Yasuhiro Minami, Bert W. O'Malley, Shigeaki Kato. (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311474 Fri, 26 Feb 2010 04:00:11 +0100 3311474 http://www.medworm.com/index.php?rid=3311473&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900070-5 Silvia Jimeno-González, Line Lindegaard Haaning, Francisco Malagon, Torben Heick Jensen. Termination of RNA polymerase II (RNAPII) transcription of protein-coding genes occurs downstream of cleavage/polyadenylation sites. According to the “torpedo” model, the 5′-3′ exonuclease Rat1p/X.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311473 Fri, 26 Feb 2010 04:00:11 +0100 3311473 http://www.medworm.com/index.php?rid=3311472&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900073-0 Kimberly C. Tu, Tao Long, Sine L. Svenningsen, Ned S. Wingreen, Bonnie L. Bassler. Quorum-sensing (QS) bacteria assess population density through secretion and detection of molecules called autoinducers (AIs). We identify and characterize two Vibrio harveyi negative feedb.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311472 Fri, 26 Feb 2010 04:00:11 +0100 3311472 http://www.medworm.com/index.php?rid=3311471&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900121-8 Pinglong Xu, Rik Derynck. Inflammatory stimuli activate ectodomain shedding of TNF-α, L-selectin, and other transmembrane proteins. We show that p38 MAP kinase, which is activated in response to inflammatory or stress sign.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311471 Fri, 26 Feb 2010 04:00:11 +0100 3311471 http://www.medworm.com/index.php?rid=3311470&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900043-2 Naoto Hoshi, Lorene K. Langeberg, Christine M. Gould, Alexandra C. Newton, John D. Scott. A-kinase anchoring proteins (AKAPs) coordinate cell signaling events. AKAP79 brings together different combinations of enzyme binding partners to customize the regulation of effector proteins. In .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311470 Fri, 26 Feb 2010 04:00:11 +0100 3311470 http://www.medworm.com/index.php?rid=3311469&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900044-4 Cole M. Haynes, Yun Yang, Steven P. Blais, Thomas A. Neubert, David Ron. Genetic analyses previously implicated the matrix-localized protease ClpP in signaling the stress of protein misfolding in the mitochondrial matrix to activate nuclear-encoded mitochondrial chaper.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311469 Fri, 26 Feb 2010 04:00:11 +0100 3311469 http://www.medworm.com/index.php?rid=3311468&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900068-7 Melanie Bien, Sebastian Longen, Nikola Wagener, Ilona Chwalla, Johannes M. Herrmann, Jan Riemer. The disulfide relay system in the intermembrane space of mitochondria is of crucial importance for mitochondrial biogenesis. Major players in this pathway are the oxidoreductase Mia40 that oxidize.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311468 Fri, 26 Feb 2010 04:00:11 +0100 3311468 http://www.medworm.com/index.php?rid=3311467&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900069-9 Florian Renner, Rita Moreno, M. Lienhard Schmitz. The IKK-related kinase IKKɛ contributes to the antiviral response and can function as an oncogene that is frequently amplified in breast cancer. Here we report on an additional role of IKKɛ as a m.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311467 Fri, 26 Feb 2010 04:00:11 +0100 3311467 http://www.medworm.com/index.php?rid=3311466&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900072-9 Eva Petermann, Manuel Luís Orta, Natalia Issaeva, Niklas Schultz, Thomas Helleday. Faithful DNA replication is essential to all life. Hydroxyurea (HU) depletes the cells of dNTPs, which initially results in stalled replication forks that, after prolonged treatment, collapse into.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311466 Fri, 26 Feb 2010 04:00:11 +0100 3311466 http://www.medworm.com/index.php?rid=3311465&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900042-0 Christopher D. Downey, Charles S. McHenry. Cellular replicases contain multiprotein ATPases that load sliding clamp processivity factors onto DNA. We reveal an additional role for the DnaX clamp loader: chaperoning of the replicative polym.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311465 Fri, 26 Feb 2010 04:00:11 +0100 3311465 http://www.medworm.com/index.php?rid=3311464&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900071-7 Rebecca J. Burgess, Hui Zhou, Junhong Han, Zhiguo Zhang. Acetylation of lysine residues at the H3 N terminus is proposed to function in replication-coupled (RC) nucleosome assembly, a process critical for the inheritance of epigenetic information and ma.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311464 Fri, 26 Feb 2010 04:00:11 +0100 3311464 http://www.medworm.com/index.php?rid=3311463&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900110-3 Peter J. Skene, Robert S. Illingworth, Shaun Webb, Alastair R.W. Kerr, Keith D. James, Daniel J. Turner, Rob Andrews, Adrian P. Bird. MeCP2 is a nuclear protein with an affinity for methylated DNA that can recruit histone deacetylases. Deficiency or excess of MeCP2 causes severe neurological problems, suggesting that the number .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311463 Fri, 26 Feb 2010 04:00:11 +0100 3311463 http://www.medworm.com/index.php?rid=3311462&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900127-9 John T. Prince, Natalie G. Ahn. In this issue of Molecular Cell, Hoshi et al. (2010) report two examples in which small molecule inhibitors are rendered ineffective when their kinase targets are involved in protein-protei.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311462 Fri, 26 Feb 2010 04:00:11 +0100 3311462 http://www.medworm.com/index.php?rid=3311461&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900119-X David F. Allison, Marty W. Mayo. Although IKK-related kinases are known to augment immune pathways, their importance to DNA-damage response has not been previously elucidated; in this issue of Molecular Cell, Renner et al..... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311461 Fri, 26 Feb 2010 04:00:11 +0100 3311461 http://www.medworm.com/index.php?rid=3311460&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900122-X Sonia Cohen, Michael E. Greenberg. In this issue of Molecular Cell, work from Skene, Bird, and colleagues reexamines MeCP2 function in the brain by characterizing the abundance and distribution of MeCP2 protein in mouse neur.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311460 Fri, 26 Feb 2010 04:00:11 +0100 3311460 http://www.medworm.com/index.php?rid=3311459&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900120-6 George Fromm, Karen Adelman. Recently in Molecular Cell, Lin et al. (2010) showed that multiple MLL-fusion proteins implicated in mixed-lineage leukemia (MLL) associate with AFF4, ELLs, and the positive transcription e.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3311459 Fri, 26 Feb 2010 04:00:11 +0100 3311459 http://www.medworm.com/index.php?rid=3266793&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Ffulltext%2FS1097-2765%2810%2900083-3 Jean-François Lemay, Annie D'Amours, Caroline Lemieux, Daniel H. Lackner, Valérie G. St-Sauveur, Jürg Bähler, François Bachand. (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266793 Fri, 12 Feb 2010 04:00:16 +0100 3266793 http://www.medworm.com/index.php?rid=3266792&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900027-4 In this study, we report a specific interaction between TopBP1 and BACH1/FANCJ, a DNA helicase involved in the repa.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266792 Fri, 12 Feb 2010 04:00:16 +0100 3266792 http://www.medworm.com/index.php?rid=3266791&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900080-8 Chengqi Lin, Edwin R. Smith, Hidehisa Takahashi, Ka Chun Lai, Skylar Martin-Brown, Laurence Florens, Michael P. Washburn, Joan W. Conaway, Ronald C. Conaway, Ali Shilatifard. Chromosomal translocations involving the MLL gene are associated with infant acute lymphoblastic and mixed lineage leukemia. There are a large number of translocation partners of MLL that s.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266791 Fri, 12 Feb 2010 04:00:16 +0100 3266791 http://www.medworm.com/index.php?rid=3266790&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900045-6 Luca Giorgetti, Trevor Siggers, Guido Tiana, Greta Caprara, Samuele Notarbartolo, Teresa Corona, Manolis Pasparakis, Paolo Milani, Martha L. Bulyk, Gioacchino Natoli. A paradigm in transcriptional regulation is that graded increases in transcription factor (TF) concentration are translated into on/off transcriptional responses by cooperative TF binding to adjac.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266790 Fri, 12 Feb 2010 04:00:16 +0100 3266790 http://www.medworm.com/index.php?rid=3266789&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900077-8 Martha G. Bomar, Sanjay D'Souza, Marzena Bienko, Ivan Dikic, Graham C. Walker, Pei Zhou. Translesion synthesis is an essential cell survival strategy to promote replication after DNA damage. The accumulation of Y family polymerases (pol) ι and Rev1 at the stalled replication machinery.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266789 Fri, 12 Feb 2010 04:00:16 +0100 3266789 http://www.medworm.com/index.php?rid=3266788&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900078-X Marzena Bienko, Catherine M. Green, Simone Sabbioneda, Nicola Crosetto, Ivan Matic, Richard G. Hibbert, Tihana Begovic, Atsuko Niimi, Matthias Mann, Alan R. Lehmann, Ivan Dikic. DNA polymerase η is a Y family polymerase involved in translesion synthesis (TLS). Its action is initiated by simultaneous interaction between the PIP box in pol η and PCNA and between the UBZ in .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266788 Fri, 12 Feb 2010 04:00:16 +0100 3266788 http://www.medworm.com/index.php?rid=3266787&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900075-4 Wenyu Wen, Jiang Yu, Lifeng Pan, Zhiyi Wei, Jingwei Weng, Wenning Wang, Yan Shan Ong, Ton Hoai Thi Tran, Wanjin Hong, Mingjie Zhang. While most SNAREs are permanently anchored to membranes by their transmembrane domains, the dually lipidated SNARE Ykt6 is found both on intracellular membranes and in the cytosol. The cytosolic Y.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266787 Fri, 12 Feb 2010 04:00:16 +0100 3266787 http://www.medworm.com/index.php?rid=3266786&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900076-6 Patrick D. Allaire, Andrea L. Marat, Claudia Dall'Armi, Gilbert Di Paolo, Peter S. McPherson, Brigitte Ritter. The DENN domain is an evolutionarily ancient protein module. Mutations in the DENN domain cause developmental defects in plants and human diseases, yet the function of this common module is unknow.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266786 Fri, 12 Feb 2010 04:00:16 +0100 3266786 http://www.medworm.com/index.php?rid=3266785&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900026-2 Jurre Hageman, Maria A. Rujano, Maria A.W.H. van Waarde, Vaishali Kakkar, Ron P. Dirks, Natalia Govorukhina, Henderika M.J. Oosterveld-Hut, Nicolette H. Lubsen, Harm H. Kampinga. Misfolding and aggregation are associated with cytotoxicity in several protein folding diseases. A large network of molecular chaperones ensures protein quality control. Here, we show that within .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266785 Fri, 12 Feb 2010 04:00:16 +0100 3266785 http://www.medworm.com/index.php?rid=3266784&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900031-6 Marco Retzlaff, Franz Hagn, Lars Mitschke, Martin Hessling, Frederik Gugel, Horst Kessler, Klaus Richter, Johannes Buchner. The chaperone Hsp90 is an ATP-dependent, dimeric molecular machine regulated by several cochaperones, including inhibitors and the unique ATPase activator Aha1. Here, we analyzed the mechanism of .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266784 Fri, 12 Feb 2010 04:00:16 +0100 3266784 http://www.medworm.com/index.php?rid=3266783&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900030-4 Mehdi Mollapour, Shinji Tsutsumi, Alison C. Donnelly, Kristin Beebe, Mari J. Tokita, Min-Jung Lee, Sunmin Lee, Giulia Morra, Dimitra Bourboulia, Bradley T. Scroggins, Giorgio Colombo, Brian S. Blagg, Barry Panaretou, William G. Stetler-Stevenson, Jane B. Trepel, Peter W. Piper, Chrisostomos Prodromou, Laurence H. Pearl, Len Neckers. Saccharomyces WEE1 (Swe1), the only “true” tyrosine kinase in budding yeast, is an Hsp90 client protein. Here we show that Swe1Wee1 phosphorylates a conserved tyrosine residue (Y.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266783 Fri, 12 Feb 2010 04:00:16 +0100 3266783 http://www.medworm.com/index.php?rid=3266782&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900029-8 Weiwen Long, Ping Yi, Larbi Amazit, Heather L. LaMarca, Felicity Ashcroft, Rakesh Kumar, Michael A. Mancini, Sophia Y. Tsai, Ming-Jer Tsai, Bert W. O'Malley. EGF induces signal transduction between EGFR and FAK, and FAK is required for EGF-induced cell migration. It is unknown, however, what factor mediates the interaction between EGFR and FAK and lead.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266782 Fri, 12 Feb 2010 04:00:16 +0100 3266782 http://www.medworm.com/index.php?rid=3266781&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900028-6 Michael A. Kohanski, Mark A. DePristo, James J. Collins. Antibiotic resistance arises through mechanisms such as selection of naturally occurring resistant mutants and horizontal gene transfer. Recently, oxidative stress has been implicated as one of th.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266781 Fri, 12 Feb 2010 04:00:16 +0100 3266781 http://www.medworm.com/index.php?rid=3266780&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900079-1 Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green. B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane i.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266780 Fri, 12 Feb 2010 04:00:16 +0100 3266780 http://www.medworm.com/index.php?rid=3266779&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900081-X Benjamin B. Kaufmann, Deborah T. Hung. In this issue of Molecular Cell, Kohanski et al. (2010) demonstrate that even subinhibitory concentrations of bactericidal antibiotics result in the generation of reactive oxygen species, l.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266779 Fri, 12 Feb 2010 04:00:16 +0100 3266779 http://www.medworm.com/index.php?rid=3266778&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900082-1 Matthias P. Mayer. In this issue of Molecular Cell, Mollapour et al. (2010) report a new tyrosine phosphorylation site in Hsp90, which is essential for Hsp90's interaction with a subset of its client proteins.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3266778 Fri, 12 Feb 2010 04:00:16 +0100 3266778 http://www.medworm.com/index.php?rid=3220279&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900038-9 Ursula Grazini, Federica Zanardi, Elisabetta Citterio, Stefano Casola, Colin R. Goding, Fraser McBlane. The RAG1 and RAG2 proteins are the only lymphoid-specific factors required to perform the first step of V(D)J recombination, DNA cleavage. While the catalytic domain of RAG1, the core region, has .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220279 Fri, 29 Jan 2010 04:00:17 +0100 3220279 http://www.medworm.com/index.php?rid=3220278&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900956-3 Glenn M. Sanders, H. Garry Dallmann, Charles S. McHenry. We have expressed and purified 13 proteins predicted to be required for B. subtilis DNA replication. When combined with a circular DNA template with a 5′ unpaired flap, these proteins recon.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220278 Fri, 29 Jan 2010 04:00:17 +0100 3220278 http://www.medworm.com/index.php?rid=3220277&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900957-5 Jordan D. Ward, Diego M. Muzzini, Mark I.R. Petalcorin, Enrique Martinez-Perez, Julie S. Martin, Paolo Plevani, Giuseppe Cassata, Federica Marini, Simon J. Boulton. Homologous recombination (HR) is essential for repair of meiotic DNA double-strand breaks (DSBs). Although the mechanisms of RAD-51-DNA filament assembly and strand exchange are well characterized.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220277 Fri, 29 Jan 2010 04:00:17 +0100 3220277 http://www.medworm.com/index.php?rid=3220276&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900963-0 Ivar Ilves, Tatjana Petojevic, James J. Pesavento, Michael R. Botchan. MCM2-7 proteins provide essential helicase functions in eukaryotes at chromosomal DNA replication forks. During the G1 phase of the cell cycle, they remain loaded on DNA but are inactive. We have .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220276 Fri, 29 Jan 2010 04:00:17 +0100 3220276 http://www.medworm.com/index.php?rid=3220275&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900953-8 Robert J. Lake, Anastasia Geyko, Girish Hemashettar, Yu Zhao, Hua-Ying Fan. The ATP-dependent chromatin remodeler CSB is essential for transcription-coupled DNA repair, and mutations in CSB lead to Cockayne syndrome. Here, we examined the recruitment of CSB to chromatin a.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220275 Fri, 29 Jan 2010 04:00:17 +0100 3220275 http://www.medworm.com/index.php?rid=3220274&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900958-7 Laura B. Motta-Mena, Florian Heyd, Kristen W. Lynch. Splicing regulatory proteins often have distinct activities when bound to exons versus introns. However, less clear is whether variables aside from location can influence activity. HnRNP L binds t.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220274 Fri, 29 Jan 2010 04:00:17 +0100 3220274 http://www.medworm.com/index.php?rid=3220273&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900032-8 Fulvia Bono, Atlanta G. Cook, Marlene Grünwald, Judith Ebert, Elena Conti. Mago and Y14 are core components of the exon junction complex (EJC), an assembly central to nonsense-mediated mRNA decay in humans and mRNA localization in flies. The Mago-Y14 heterodimer shuttles.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220273 Fri, 29 Jan 2010 04:00:17 +0100 3220273 http://www.medworm.com/index.php?rid=3220272&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900969-1 Andrey V. Pisarev, Maxim A. Skabkin, Vera P. Pisareva, Olga V. Skabkina, Aurélie M. Rakotondrafara, Matthias W. Hentze, Christopher U.T. Hellen, Tatyana V. Pestova. After termination, eukaryotic 80S ribosomes remain associated with mRNA, P-site deacylated tRNA, and release factor eRF1 and must be recycled by dissociating these ligands and separating ribosomes.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220272 Fri, 29 Jan 2010 04:00:17 +0100 3220272 http://www.medworm.com/index.php?rid=3220271&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900952-6 Ji Min Lee, Ik Soo Kim, Hyunkyung Kim, Jason S. Lee, Kyeongkyu Kim, Hwa Young Yim, Jiyeong Jeong, Jung Hwa Kim, Ji-Young Kim, Hanna Lee, Sang-Beom Seo, Hogeun Kim, Michael G. Rosenfeld, Keun Il Kim, Sung Hee Baek. Wnt family members play diverse roles in development and disease. Noncanonical Wnt ligands can inhibit canonical Wnt signaling depending on the cellular context; however, the underlying mechanism .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220271 Fri, 29 Jan 2010 04:00:17 +0100 3220271 http://www.medworm.com/index.php?rid=3220270&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900039-0 Nicholas Paquette, Meike Broemer, Kamna Aggarwal, Li Chen, Marie Husson, Deniz Ertürk-Hasdemir, Jean-Marc Reichhart, Pascal Meier, Neal Silverman. Innate immune responses are critical for the immediate protection against microbial infection. In Drosophila, infection leads to the rapid and robust production of antimicrobial peptides th.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220270 Fri, 29 Jan 2010 04:00:17 +0100 3220270 http://www.medworm.com/index.php?rid=3220269&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900954-X Jörg Hartkamp, Brian Carpenter, Stefan G.E. Roberts. The Wilms' tumor suppressor protein WT1 functions as a transcriptional regulator of genes controlling growth, apoptosis, and differentiation. It has become clear that WT1 can act as an oncogene in.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220269 Fri, 29 Jan 2010 04:00:17 +0100 3220269 http://www.medworm.com/index.php?rid=3220268&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900036-5 Ashley B. Williams, W. Matthew Michael. In this issue of Molecular Cell, Ward et al. (2010) identify two genes whose products act redundantly to clear Rad51 from DNA after successful strand invasion, thereby enabling the downstre.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220268 Fri, 29 Jan 2010 04:00:17 +0100 3220268 http://www.medworm.com/index.php?rid=3220267&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900035-3 Alan R. Kimmel. In this issue of Molecular Cell, Lee et al. (2010) show that the retinoic acid receptor-related orphan receptor alpha (RORα) can suppress the Wnt/β-catenin signaling pathway in a Wnt5a- and.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220267 Fri, 29 Jan 2010 04:00:17 +0100 3220267 http://www.medworm.com/index.php?rid=3220266&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900037-7 Abdelkader Essafi, Nicholas D. Hastie. Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic st.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220266 Fri, 29 Jan 2010 04:00:17 +0100 3220266 http://www.medworm.com/index.php?rid=3220265&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900040-7 Uri Alon. Motivated group members experience a full sense of choice: of doing what one wants. Such behavior shows high performance, is enjoyable, and enhances innovation. This essay describes principles of .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220265 Fri, 29 Jan 2010 04:00:16 +0100 3220265 http://www.medworm.com/index.php?rid=3220264&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2810%2900041-9 We present evidence for successive engagement of.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3220264 Fri, 29 Jan 2010 04:00:16 +0100 3220264 http://www.medworm.com/index.php?rid=3175711&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900922-8 Kenta Terai, Tarek Abbas, Amir A. Jazaeri, Anindya Dutta. Monoubiquitination of proliferating cell nuclear antigen (PCNA) is a critical posttranslational modification essential for DNA repair by translesion DNA synthesis (TLS). The Rad18 E3 ubiquitin lig.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175711 Fri, 15 Jan 2010 04:00:15 +0100 3175711 http://www.medworm.com/index.php?rid=3175710&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900920-4 Hal P. Bogerd, Heather W. Karnowski, Xuezhong Cai, Jinwook Shin, Michael Pohlers, Bryan R. Cullen. Canonical primary microRNA (pri-miRNA) precursors are transcribed by RNA polymerase II and then processed by the Drosha endonuclease to generate ∼60 nt pre-miRNA hairpins. Pre-miRNAs in turn are c.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175710 Fri, 15 Jan 2010 04:00:14 +0100 3175710 http://www.medworm.com/index.php?rid=3175709&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900965-4 Yukihide Watanabe, Susumu Itoh, Toshiyasu Goto, Eriko Ohnishi, Masako Inamitsu, Fumiko Itoh, Kiyotoshi Satoh, Eliza Wiercinska, Weiwen Yang, Liang Shi, Aya Tanaka, Naoko Nakano, A. Mieke Mommaas, Hiroshi Shibuya, Peter ten Dijke, Mitsuyasu Kato. Transforming growth factor-β (TGF-β) is a multifunctional cytokine of key importance for controlling embryogenesis and tissue homeostasis. How TGF-β signals are attenuated and terminated is not we.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175709 Fri, 15 Jan 2010 04:00:14 +0100 3175709 http://www.medworm.com/index.php?rid=3175708&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900924-1 Yu Wang, Chang Liu, Daiwen Yang, Hao Yu, Yih-Cherng Liou. Floral transition in plants is regulated by an integrated network of flowering genetic pathways. We show that an Arabidopsis PIN1-type parvulin 1, Pin1At, controls floral transition by acce.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175708 Fri, 15 Jan 2010 04:00:14 +0100 3175708 http://www.medworm.com/index.php?rid=3175707&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900955-1 James E. Brownell, Michael D. Sintchak, James M. Gavin, Hua Liao, Frank J. Bruzzese, Nancy J. Bump, Teresa A. Soucy, Michael A. Milhollen, Xiaofeng Yang, Anne L. Burkhardt, Jingya Ma, Huay-Keng Loke, Trupti Lingaraj, Dongyun Wu, Kristin B. Hamman, James J. Spelman, Courtney A. Cullis, Steven P. Langston, Stepan Vyskocil, Todd B. Sells, William D. Mallender, Irache Visiers, Ping Li, Christopher F. Claiborne, Mark Rolfe, Joseph B. Bolen, Lawrence R. Dick. The NEDD8-activating enzyme (NAE) initiates a protein homeostatic pathway essential for cancer cell growth and survival. MLN4924 is a selective inhibitor of NAE currently in clinical trials for th.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175707 Fri, 15 Jan 2010 04:00:14 +0100 3175707 http://www.medworm.com/index.php?rid=3175706&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900964-2 This report shows that mutant proteins bearing alanine substitutions for two c.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175706 Fri, 15 Jan 2010 04:00:14 +0100 3175706 http://www.medworm.com/index.php?rid=3175705&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900919-8 Takayuki Sekimoto, Tsukasa Oda, Franklin Mayca Pozo, Yoshiki Murakumo, Chikahide Masutani, Fumio Hanaoka, Takayuki Yamashita. DNA polymerase η (Pol η) is a member of the mammalian Y family polymerases and performs error-free translesion synthesis across UV-damaged DNA. For this function, Pol η accumulates in nuclear foci.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175705 Fri, 15 Jan 2010 04:00:14 +0100 3175705 http://www.medworm.com/index.php?rid=3175704&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900925-3 Javier Miralles Fusté, Sjoerd Wanrooij, Elisabeth Jemt, Caroline E. Granycome, Tricia J. Cluett, Yonghong Shi, Neli Atanassova, Ian J. Holt, Claes M. Gustafsson, Maria Falkenberg. Mitochondrial DNA is replicated by a unique enzymatic machinery, which is distinct from the replication apparatus used for copying the nuclear genome. We examine here the mechanisms of origin-spec.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175704 Fri, 15 Jan 2010 04:00:14 +0100 3175704 http://www.medworm.com/index.php?rid=3175703&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900916-2 Benoit Miotto, Kevin Struhl. HBO1, an H4-specific histone acetylase, is a coactivator of the DNA replication licensing factor Cdt1. HBO1 acetylase activity is required for licensing, because a histone acetylase (HAT)-defectiv.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175703 Fri, 15 Jan 2010 04:00:14 +0100 3175703 http://www.medworm.com/index.php?rid=3175702&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900921-6 Lauriane Fritsch, Philippe Robin, Jacques R.R. Mathieu, Mouloud Souidi, Hélène Hinaux, Claire Rougeulle, Annick Harel-Bellan, Maya Ameyar-Zazoua, Slimane Ait-Si-Ali. Lysine 9 of histone 3 (H3K9) can be mono-, di-, or trimethylated, inducing distinct effects on gene expression and chromatin compaction. H3K9 methylation can be mediated by several histone methylt.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175702 Fri, 15 Jan 2010 04:00:14 +0100 3175702 http://www.medworm.com/index.php?rid=3175701&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900923-X Jean-François Lemay, Annie D'Amours, Caroline Lemieux, Daniel H. Lackner, Valérie G. St-Sauveur, Jürg Bähler, François Bachand. Poly(A)-binding proteins (PABPs) are important to eukaryotic gene expression. In the nucleus, the PABP PABPN1 is thought to function in polyadenylation of pre-mRNAs. Deletion of fission yeast p.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175701 Fri, 15 Jan 2010 04:00:14 +0100 3175701 http://www.medworm.com/index.php?rid=3175700&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900966-6 Anna Maria Giuliodori, Fabio Di Pietro, Stefano Marzi, Benoit Masquida, Rolf Wagner, Pascale Romby, Claudio O. Gualerzi, Cynthia L. Pon. Cold induction of cspA, the paradigm Escherichia coli cold-shock gene, is mainly subject to posttranscriptional control, partly promoted by cis-acting elements of its transcri.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175700 Fri, 15 Jan 2010 04:00:14 +0100 3175700 http://www.medworm.com/index.php?rid=3175699&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900968-X Fedor V. Karginov, Gregory J. Hannon. All cellular systems evolve ways to combat predators and genomic parasites. In bacteria and archaea, numerous resistance mechanisms have developed against phage. Our understanding of this defensiv.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175699 Fri, 15 Jan 2010 04:00:14 +0100 3175699 http://www.medworm.com/index.php?rid=3175698&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900961-7 Gaganmeet Singh Chadha, J. Julian Blow. In this issue of Molecular Cell, Miotto and Struhl (2010) suggest that replication licensing, the loading of Mcm2-7 onto DNA, is promoted by HBO1 acetylating histone H4 at replication origi.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175698 Fri, 15 Jan 2010 04:00:14 +0100 3175698 http://www.medworm.com/index.php?rid=3175697&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900962-9 Domenico Libri. Recent work from Lemay et al. (2010) in this issue of Molecular Cell reveals a role for a nuclear poly(A)-binding protein in promoting degradation of small nucleolar RNAs (snoRNAs) by the n.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175697 Fri, 15 Jan 2010 04:00:14 +0100 3175697 http://www.medworm.com/index.php?rid=3175696&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900967-8 Ronald R. Breaker. In this issue of Molecular Cell, Giuliodori et al. (2010) describe a cold-induced genetic switch made of RNA. Could thermo-sensing RNAs be among the most common types of RNA genetic switches? (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3175696 Fri, 15 Jan 2010 04:00:14 +0100 3175696 http://www.medworm.com/index.php?rid=3120334&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900824-7 Hari B. Kamadurai, Judith Souphron, Daniel C. Scott, David M. Duda, Darcie J. Miller, Daniel Stringer, Robert C. Piper, Brenda A. Schulman. In E1-E2-E3 ubiquitin (Ub) conjugation cascades, the E2 first forms a transient E2∼Ub covalent complex and then interacts with an E3 for Ub transfer. For cascades involving E3s in the HECT class, .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120334 Fri, 25 Dec 2009 04:00:15 +0100 3120334 http://www.medworm.com/index.php?rid=3120333&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900914-9 Sarah Javaid, Mridula Manohar, Nidhi Punja, Alex Mooney, Jennifer J. Ottesen, Michael G. Poirier, Richard Fishel. DNA nucleotide mismatches and lesions arise on chromosomes that are a complex assortment of protein and DNA (chromatin). The fundamental unit of chromatin is a nucleosome that contains ∼146 bp DNA.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120333 Fri, 25 Dec 2009 04:00:15 +0100 3120333 http://www.medworm.com/index.php?rid=3120332&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900913-7 Christine Demange, Nathalie Ferrand, Céline Prunier, Marie-Francoise Bourgeade, Azeddine Atfi. The homeodomain protein TGIF functions as a negative regulator of multiple classes of transcription factors. Here we report on the characterization of TGIF as an essential component of the tumor n.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120332 Fri, 25 Dec 2009 04:00:15 +0100 3120332 http://www.medworm.com/index.php?rid=3120331&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900828-4 Stefan Schoebel, Lena Katharina Oesterlin, Wulf Blankenfeldt, Roger Sidney Goody, Aymelt Itzen. Prenylated Rab proteins exist in the cytosol as soluble, high-affinity complexes with GDI that need to be disrupted for membrane attachment and targeting of Rab proteins. The Legionella pneumop.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120331 Fri, 25 Dec 2009 04:00:15 +0100 3120331 http://www.medworm.com/index.php?rid=3120330&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900819-3 Kvido Strisovsky, Hayley J. Sharpe, Matthew Freeman. Members of the widespread rhomboid family of intramembrane proteases cleave transmembrane domain (TMD) proteins to regulate processes as diverse as EGF receptor signaling, mitochondrial dynamics, .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120330 Fri, 25 Dec 2009 04:00:15 +0100 3120330 http://www.medworm.com/index.php?rid=3120329&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900862-4 Jean-François Trempe, Carol X.-Q. Chen, Karl Grenier, Edna Matta Camacho, Guennadi Kozlov, Peter S. McPherson, Kalle Gehring, Edward A. Fon. Mutations in the parkin gene are responsible for a common inherited form of Parkinson's disease (PD). Parkin is a RING-type E3 ubiquitin ligase with an N-terminal ubiquitin-like domain (Ubl.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120329 Fri, 25 Dec 2009 04:00:15 +0100 3120329 http://www.medworm.com/index.php?rid=3120328&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900826-0 Daoning Zhang, Tony Chen, Inbal Ziv, Rina Rosenzweig, Yulia Matiuhin, Vered Bronner, Michael H. Glickman, David Fushman. As a signal for substrate targeting, polyubiquitin meets various layers of receptors upstream to the 26S proteasome. We obtained structural information on two receptors, Rpn10 and Dsk2, alone and .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120328 Fri, 25 Dec 2009 04:00:15 +0100 3120328 http://www.medworm.com/index.php?rid=3120327&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900827-2 Akira Fukao, Yumi Sasano, Hiroaki Imataka, Kunio Inoue, Hiroshi Sakamoto, Nahum Sonenberg, Christian Thoma, Toshinobu Fujiwara. The RNA-binding protein HuD promotes neuronal differentiation by an unknown mechanism. Here we identify an enhancer function of HuD in translation. Translation stimulation by HuD requires both a 3.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120327 Fri, 25 Dec 2009 04:00:15 +0100 3120327 http://www.medworm.com/index.php?rid=3120326&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900907-1 Yuanchao Xue, Yu Zhou, Tongbin Wu, Tuo Zhu, Xiong Ji, Young-Soo Kwon, Chao Zhang, Gene Yeo, Douglas L. Black, Hui Sun, Xiang-Dong Fu, Yi Zhang. Recent transcriptome analysis indicates that > 90% of human genes undergo alternative splicing, underscoring the contribution of differential RNA processing to diverse proteomes in higher eukar.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120326 Fri, 25 Dec 2009 04:00:15 +0100 3120326 http://www.medworm.com/index.php?rid=3120325&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900818-1 Hsiang-Ying Lee, Kirby D. Johnson, Tohru Fujiwara, Meghan E. Boyer, Shin-Il Kim, Emery H. Bresnick. GATA factors establish transcriptional networks that control fundamental developmental processes. Whereas the regulator of hematopoiesis GATA-1 is subject to multiple posttranslational modificatio.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120325 Fri, 25 Dec 2009 04:00:15 +0100 3120325 http://www.medworm.com/index.php?rid=3120324&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900904-6 Gerd A. Blobel, Stephan Kadauke, Eric Wang, Alan W. Lau, Johannes Zuber, Margaret M. Chou, Christopher R. Vakoc. Mixed lineage leukemia (MLL) and its metazoan Trithorax orthologs have been linked with the epigenetic maintenance of transcriptional activity. To identify mechanisms by which MLL perpetuates acti.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120324 Fri, 25 Dec 2009 04:00:15 +0100 3120324 http://www.medworm.com/index.php?rid=3120323&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900905-8 Zhongsheng You, Linda Z. Shi, Quan Zhu, Peng Wu, You-Wei Zhang, Andrew Basilio, Nina Tonnu, Inder M. Verma, Michael W. Berns, Tony Hunter. In response to DNA double-strand breaks (DSBs), cells sense the DNA lesions and then activate the protein kinase ATM. Subsequent DSB resection produces RPA-coated ssDNA that is essential for activ.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120323 Fri, 25 Dec 2009 04:00:15 +0100 3120323 http://www.medworm.com/index.php?rid=3120322&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900910-1 Andrew J. Deans, Stephen C. West. Fanconi Anemia (FA) and Bloom's Syndrome (BS) are genetic disorders characterized by overlapping phenotypes, including aberrant DNA repair and cancer predisposition. Here, we show that the FANC.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120322 Fri, 25 Dec 2009 04:00:15 +0100 3120322 http://www.medworm.com/index.php?rid=3120321&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900861-2 J. Ross Buchan, Roy Parker. The stress response in eukaryotic cells often inhibits translation initiation and leads to the formation of cytoplasmic RNA-protein complexes referred to as stress granules. Stress granules contai.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120321 Fri, 25 Dec 2009 04:00:15 +0100 3120321 http://www.medworm.com/index.php?rid=3120320&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900915-0 Joseph A. D'Alessio, Kevin J. Wright, Robert Tjian. Historically, developmental-stage- and tissue-specific patterns of gene expression were assumed to be determined primarily by DNA regulatory sequences and their associated activators, while the ge.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120320 Fri, 25 Dec 2009 04:00:15 +0100 3120320 http://www.medworm.com/index.php?rid=3120319&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900909-5 Bilal Amarneh, Robert B. Rawson. In this issue of Molecular Cell, Strisovsky et al. (2009) identify a sequence motif underlying cleavage site specificity for the rhomboid proteases. This sheds light on potential mechanisms.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120319 Fri, 25 Dec 2009 04:00:15 +0100 3120319 http://www.medworm.com/index.php?rid=3120318&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900917-4 Chyi-Ying A. Chen, Ann-Bin Shyu. In this issue of Molecular Cell, Fukao et al. (2009) report that HuD upregulates mRNA translation through direct interaction with eIF4A in the 5′ cap-binding complex, revealing a posttransc.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120318 Fri, 25 Dec 2009 04:00:15 +0100 3120318 http://www.medworm.com/index.php?rid=3120317&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900908-3 Anna Corrionero, Juan Valcárcel. Using genome-wide RNA-binding data, Xue et al. (2009) draw a regulatory map in this issue of Molecular Cell for the much-studied polypyrimidine tract-binding protein (PTB) that reveals a un.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120317 Fri, 25 Dec 2009 04:00:15 +0100 3120317 http://www.medworm.com/index.php?rid=3120316&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900911-3 Patrizia Vinciguerra, Alan D. D'Andrea. In this issue of Molecular Cell, Deans and West (2009) reveal the molecular basis of the phenotypic similarities between Fanconi Anemia (FA) and Bloom's Syndrome, identifying FANCM as the a.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120316 Fri, 25 Dec 2009 04:00:15 +0100 3120316 http://www.medworm.com/index.php?rid=3120315&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900912-5 Ron Milo, Maya Schuldiner. The academic path is a challenging journey full of hurdles and without a clear roadmap. As young faculty, we searched for support in steering through the complexities of our new roles. Here we des.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3120315 Fri, 25 Dec 2009 04:00:15 +0100 3120315 http://www.medworm.com/index.php?rid=3079174&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900857-0 Hani Goodarzi, Olivier Elemento, Saeed Tavazoie. The discovery of pathways and regulatory networks whose perturbation contributes to neoplastic transformation remains a fundamental challenge for cancer biology. We show that such pathway perturba.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079174 Fri, 11 Dec 2009 04:00:16 +0100 3079174 http://www.medworm.com/index.php?rid=3079173&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900859-4 Lea Goentoro, Oren Shoval, Marc W. Kirschner, Uri Alon. Many sensory systems (e.g., vision and hearing) show a response that is proportional to the fold-change in the stimulus relative to the background, a feature related to Weber's Law. Recent experim.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079173 Fri, 11 Dec 2009 04:00:16 +0100 3079173 http://www.medworm.com/index.php?rid=3079172&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900866-1 Cellina Cohen-Saidon, Ariel A. Cohen, Alex Sigal, Yuvalal Liron, Uri Alon. Signal-transduction cascades are usually studied on cell averages, masking variability between individual cells. To address this, we studied in individual cells the dynamic response of ERK2, a wel.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079172 Fri, 11 Dec 2009 04:00:16 +0100 3079172 http://www.medworm.com/index.php?rid=3079171&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900858-2 Lea Goentoro, Marc W. Kirschner. In response to Wnt stimulation, β-catenin accumulates and activates target genes. Using modeling and experimental analysis, we found that the level of β-catenin is sensitive to perturbations in th.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079171 Fri, 11 Dec 2009 04:00:16 +0100 3079171 http://www.medworm.com/index.php?rid=3079170&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900863-6 Linda Foit, Gareth J. Morgan, Maximilian J. Kern, Lenz R. Steimer, Annekathrin A. von Hacht, James Titchmarsh, Stuart L. Warriner, Sheena E. Radford, James C.A. Bardwell. Identifying mutations that stabilize proteins is challenging because most substitutions are destabilizing. In addition to being of immense practical utility, the ability to evolve protein stabilit.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079170 Fri, 11 Dec 2009 04:00:16 +0100 3079170 http://www.medworm.com/index.php?rid=3079169&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900865-X Bryan W. Davies, Michael A. Kohanski, Lyle A. Simmons, Jonathan A. Winkler, James J. Collins, Graham C. Walker. Hydroxyurea (HU) specifically inhibits class I ribonucleotide reductase (RNR), depleting dNTP pools and leading to replication fork arrest. Although HU inhibition of RNR is well recognized, the me.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079169 Fri, 11 Dec 2009 04:00:16 +0100 3079169 http://www.medworm.com/index.php?rid=3079168&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900778-3 Tobias L. Haas, Christoph H. Emmerich, Björn Gerlach, Anna C. Schmukle, Stefanie M. Cordier, Eva Rieser, Rebecca Feltham, James Vince, Uwe Warnken, Till Wenger, Ronald Koschny, David Komander, John Silke, Henning Walczak. TNF is a key inflammatory cytokine. Using a modified tandem affinity purification approach, we identified HOIL-1 and HOIP as functional components of the native TNF-R1 signaling complex (TNF-RSC)..... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079168 Fri, 11 Dec 2009 04:00:16 +0100 3079168 http://www.medworm.com/index.php?rid=3079167&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900869-7 Koichi Fukuda, Sudhiranjan Gupta, Ka Chen, Chuanyue Wu, Jun Qin. Integrin-linked kinase (ILK) plays a pivotal role in connecting transmembrane receptor integrin to the actin cytoskeleton and thereby regulating diverse cell-adhesion-dependent processes. The kina.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079167 Fri, 11 Dec 2009 04:00:16 +0100 3079167 http://www.medworm.com/index.php?rid=3079166&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900781-3 Hiroaki Nagai, Takuya Noguchi, Kengo Homma, Kazumi Katagiri, Kohsuke Takeda, Atsushi Matsuzawa, Hidenori Ichijo. Ubiquitination is an important posttranslational modification that regulates various cellular processes, including signal transduction. However, physiological roles of ubiquitination in the regula.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079166 Fri, 11 Dec 2009 04:00:16 +0100 3079166 http://www.medworm.com/index.php?rid=3079165&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900829-6 Andreas Peth, Henrike C. Besche, Alfred L. Goldberg. In eukaryotic cells, ubiquitination of proteins leads to their degradation by the 26S proteasome. We tested if the ubiquitin (Ub) chain also regulates the proteasome's capacity for proteolysis. Af.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079165 Fri, 11 Dec 2009 04:00:16 +0100 3079165 http://www.medworm.com/index.php?rid=3079164&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900780-1 Sabine C. Horn, Jennifer Hanna, Christian Hirsch, Corinna Volkwein, Anja Schütz, Udo Heinemann, Thomas Sommer, Ernst Jarosch. Protein quality control in the endoplasmic reticulum is of central importance for cellular homeostasis in eukaryotes. Crucial for this process is the HRD-ubiquitin ligase (HMG-CoA reductase degrad.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079164 Fri, 11 Dec 2009 04:00:16 +0100 3079164 http://www.medworm.com/index.php?rid=3079163&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900825-9 Marlene Oeffinger, Daniel Zenklusen, Angelica Ferguson, Karen E. Wei, Aziz El Hage, David Tollervey, Brian T. Chait, Robert H. Singer, Michael P. Rout. Ribosomal processing requires a series of endo- and exonucleolytic steps for the production of mature ribosomes, of which most have been described. To ensure ribosome synthesis, 3′ end formation o.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079163 Fri, 11 Dec 2009 04:00:16 +0100 3079163 http://www.medworm.com/index.php?rid=3079162&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900822-3 We report that SOCS1 is required for transcriptional activity, DNA binding, and serine 15 phosphor.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079162 Fri, 11 Dec 2009 04:00:16 +0100 3079162 http://www.medworm.com/index.php?rid=3079161&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900779-5 Vasundhara M. Navadgi-Patil, Peter M. Burgers. DNA damage checkpoint pathways operate to prevent cell-cycle progression in response to DNA damage and replication stress. In S. cerevisiae, Mec1-Ddc2 (human ATR-ATRIP) is the principal che.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079161 Fri, 11 Dec 2009 04:00:15 +0100 3079161 http://www.medworm.com/index.php?rid=3079160&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900870-3 Katiuscia Bianchi, Pascal Meier. A flurry of recent revelations is challenging the current dogma on how ubiquitin-dependent processes culminate in the activation of NF-κB by TNF. Here, we integrate these findings into a model for.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079160 Fri, 11 Dec 2009 04:00:15 +0100 3079160 http://www.medworm.com/index.php?rid=3079159&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900867-3 Lee Zou. In this issue of Molecular Cell, Navadgi-Patil and Burgers show that the budding yeast Mec1 kinase is activated by DNA damage through two distinct Ddc1-mediated mechanisms during G1 and G2 .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079159 Fri, 11 Dec 2009 04:00:15 +0100 3079159 http://www.medworm.com/index.php?rid=3079158&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900860-0 John R. Prensner, Arul M. Chinnaiyan. In this issue of Molecular Cell, Goodarzi et al. (2009) employ novel computational approaches to demonstrate the power of global systems biology analyses in elucidating cancer biology. (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079158 Fri, 11 Dec 2009 04:00:15 +0100 3079158 http://www.medworm.com/index.php?rid=3079157&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900864-8 R. Luke Wiseman, Jeffery W. Kelly. In this issue of Molecular Cell, Foit et al. (2009) probe cellular protein folding using a split β-lactamase approach for evolving protein stability in the absence of any requirement for fu.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079157 Fri, 11 Dec 2009 04:00:15 +0100 3079157 http://www.medworm.com/index.php?rid=3079156&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900868-5 Tobias Bollenbach, Roy Kishony. In this issue of Molecular Cell, Davies et al. (2009) work out a sequence of active cellular events that lead to the death of Escherichia coli in the presence of the drug hydroxyurea. (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079156 Fri, 11 Dec 2009 04:00:15 +0100 3079156 http://www.medworm.com/index.php?rid=3079155&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900873-9 James E. Ferrell. New experimental and theoretical studies reported by Uri Alon, Marc Kirschner, and colleagues in this issue of Molecular Cell suggest that Weber's law of sensory perception may apply to a n.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079155 Fri, 11 Dec 2009 04:00:15 +0100 3079155 http://www.medworm.com/index.php?rid=3079154&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900872-7 Joseph D. Puglisi. This year's Nobel Prize in Chemistry rewards Ada Yonath, Tom Steitz, and Venki Ramakrishnan for their groundbreaking structural studies on the ribosome. (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079154 Fri, 11 Dec 2009 04:00:15 +0100 3079154 http://www.medworm.com/index.php?rid=3079153&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900871-5 Steven E. Artandi, Julia Promisel Cooper. The linearity of eukaryotic chromosomes presents challenges to cells, as the presence of DNA “ends” poses problems for the DNA replication machinery and the cell's damage response systems. This ye.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3079153 Fri, 11 Dec 2009 04:00:15 +0100 3079153 http://www.medworm.com/index.php?rid=3026521&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900696-0 Xuan Li, Carrie M. Stith, Peter M. Burgers, Wolf-Dietrich Heyer. Genetic recombination ensures proper chromosome segregation during meiosis and is essential for genome stability and tumor suppression. DNA synthesis after Rad51-mediated DNA strand invasion is a .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026521 Wed, 25 Nov 2009 04:00:15 +0100 3026521 http://www.medworm.com/index.php?rid=3026520&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900821-1 Grant Dewson, Tobias Kratina, Peter Czabotar, Catherine L. Day, Jerry M. Adams, Ruth M. Kluck. A pivotal step toward apoptosis is oligomerization of the Bcl-2 relative Bak. We recently reported that its oligomerization initiates by insertion of an exposed BH3 domain into the groove of anoth.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026520 Wed, 25 Nov 2009 04:00:15 +0100 3026520 http://www.medworm.com/index.php?rid=3026519&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900815-6 Ming Yu, Laura Riva, Huafeng Xie, Yocheved Schindler, Tyler B. Moran, Yong Cheng, Duonan Yu, Ross Hardison, Mitchell J. Weiss, Stuart H. Orkin, Bradley E. Bernstein, Ernest Fraenkel, Alan B. Cantor. The transcription factor GATA-1 is required for terminal erythroid maturation and functions as an activator or repressor depending on gene context. Yet its in vivo site selectivity and ability to .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026519 Wed, 25 Nov 2009 04:00:15 +0100 3026519 http://www.medworm.com/index.php?rid=3026518&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900814-4 Tohru Fujiwara, Henriette O'Geen, Sunduz Keles, Kimberly Blahnik, Amelia K. Linnemann, Yoon-A. Kang, Kyunghee Choi, Peggy J. Farnham, Emery H. Bresnick. GATA factors interact with simple DNA motifs (WGATAR) to regulate critical processes, including hematopoiesis, but very few WGATAR motifs are occupied in genomes. Given the rudimentary knowledge o.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026518 Wed, 25 Nov 2009 04:00:15 +0100 3026518 http://www.medworm.com/index.php?rid=3026517&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900823-5 Colin P. Guy, John Atkinson, Milind K. Gupta, Akeel A. Mahdi, Emma J. Gwynn, Christian J. Rudolph, Peter B. Moon, Ingeborg C. van Knippenberg, Chris J. Cadman, Mark S. Dillingham, Robert G. Lloyd, Peter McGlynn. Nucleoprotein complexes present challenges to genome stability by acting as potent blocks to replication. One attractive model of how such conflicts are resolved is direct targeting of blocked for.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026517 Wed, 25 Nov 2009 04:00:15 +0100 3026517 http://www.medworm.com/index.php?rid=3026516&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900695-9 Kaoru Sugasawa, Jun-ichi Akagi, Ryotaro Nishi, Shigenori Iwai, Fumio Hanaoka. For mammalian nucleotide excision repair (NER), DNA lesions are recognized in at least two steps involving detection of unpaired bases by the XPC protein complex and the subsequent verification of.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026516 Wed, 25 Nov 2009 04:00:15 +0100 3026516 http://www.medworm.com/index.php?rid=3026515&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900820-X Davide F. Robbiani, Samuel Bunting, Niklas Feldhahn, Anne Bothmer, Jordi Camps, Stephanie Deroubaix, Kevin M. McBride, Isaac A. Klein, Gary Stone, Thomas R. Eisenreich, Thomas Ried, André Nussenzweig, Michel C. Nussenzweig. Cancer-initiating translocations such as those associated with lymphomas require the formation of paired DNA double-strand breaks (DSBs). Activation-induced cytidine deaminase (AID) produces wides.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026515 Wed, 25 Nov 2009 04:00:15 +0100 3026515 http://www.medworm.com/index.php?rid=3026514&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900693-5 Nayef Mazloum, William K. Holloman. Accumulating evidence for Rad51-catalyzed DNA strand invasion during double-strand break repair features a 3′ single-stranded tail as the preferred substrate for reaction, but paradoxically, the p.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026514 Wed, 25 Nov 2009 04:00:15 +0100 3026514 http://www.medworm.com/index.php?rid=3026513&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900701-1 Bosun Min, Kathleen Collins. Telomerase ribonucleoprotein complexes copy an internal RNA template to synthesize DNA repeats. DNA-interacting subunits other than telomerase reverse transcriptase (TERT) and telomerase RNA (TER).... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026513 Wed, 25 Nov 2009 04:00:15 +0100 3026513 http://www.medworm.com/index.php?rid=3026512&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900700-X Patrizia Fabrizio, Julia Dannenberg, Prakash Dube, Berthold Kastner, Holger Stark, Henning Urlaub, Reinhard Lührmann. Metazoan spliceosomes exhibit an elaborate protein composition required for canonical and alternative splicing. Thus, the minimal set of proteins essential for activation and catalysis remains elu.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026512 Wed, 25 Nov 2009 04:00:15 +0100 3026512 http://www.medworm.com/index.php?rid=3026511&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900699-6 Markus T. Bohnsack, Roman Martin, Sander Granneman, Maike Ruprecht, Enrico Schleiff, David Tollervey. Yeast ribosome synthesis requires 19 different RNA helicases, but none of their pre-rRNA-binding sites were previously known, making their precise functions difficult to determine. Here we identif.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026511 Wed, 25 Nov 2009 04:00:15 +0100 3026511 http://www.medworm.com/index.php?rid=3026510&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900702-3 Kent E. Duncan, Claudia Strein, Matthias W. Hentze. Drosophila female viability requires translational repression of msl-2 mRNA by the SXL-UNR 3′ UTR corepressor complex, which inhibits ribosome recruitment by an unknown mechanism. He.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026510 Wed, 25 Nov 2009 04:00:15 +0100 3026510 http://www.medworm.com/index.php?rid=3026509&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900698-4 Mark W. Richards, Laura O'Regan, Corine Mas-Droux, Joelle M.Y. Blot, Jack Cheung, Swen Hoelder, Andrew M. Fry, Richard Bayliss. Mitosis is controlled by multiple protein kinases, many of which are abnormally expressed in human cancers. Nek2, Nek6, Nek7, and Nek9 are NIMA-related kinases essential for proper mitotic progres.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026509 Wed, 25 Nov 2009 04:00:15 +0100 3026509 http://www.medworm.com/index.php?rid=3026508&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900694-7 Haitao Ji, Ji Wang, Heinz Nika, David Hawke, Susan Keezer, Qingyuan Ge, Bingliang Fang, Xuexun Fang, Dexing Fang, David W. Litchfield, Kenneth Aldape, Zhimin Lu. Increased transcriptional activity of β-catenin resulting from Wnt/Wingless-dependent or -independent signaling has been detected in many types of human cancer, but the underlying mechanism of Wnt.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026508 Wed, 25 Nov 2009 04:00:15 +0100 3026508 http://www.medworm.com/index.php?rid=3026507&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900784-9 Stephen Buratowski. The C-terminal domain of RNA polymerase II's largest subunit undergoes dynamic phosphorylation during transcription, and the different phosphorylation patterns that predominate at each stage of tr.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026507 Wed, 25 Nov 2009 04:00:15 +0100 3026507 http://www.medworm.com/index.php?rid=3026506&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900816-8 Bertrand Llorente, Mauro Modesti. In this issue of Molecular Cell, Mazloum and Holloman (2009b) propose that 5′ end strand invasion promoted by collaboration between Rad51 and Brh2 could be used for bypassing lesions during.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026506 Wed, 25 Nov 2009 04:00:15 +0100 3026506 http://www.medworm.com/index.php?rid=3026505&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900817-X Ulf-Peter Guenther, Eckhard Jankowsky. In this issue of Molecular Cell, Bohnsack et al. (2009) identify multiple binding sites of the RNA helicase Prp43 on preribosomal RNA. The target regions suggest distinct functions of Prp43.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=3026505 Wed, 25 Nov 2009 04:00:14 +0100 3026505 http://www.medworm.com/index.php?rid=2988937&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900790-4 Gonzalo M. Rivera, Dan Vasilescu, Venizelos Papayannopoulos, Wendell A. Lim, Bruce J. Mayer. Modulation of actin dynamics through the N-WASp/Arp2/3 pathway is important in cell locomotion, membrane trafficking, and pathogen infection. Here, we demonstrate that Nck is essential for actin r.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=2988937 Fri, 13 Nov 2009 04:00:17 +0100 2988937 http://www.medworm.com/index.php?rid=2988936&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900789-8 Andres M. Lebensohn, Marc W. Kirschner. WAVE proteins link upstream signals to actin nucleation by activating the Arp2/3 complex and are at the core of regulatory pathways driving membrane protrusion. They are found in heteropentameric .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=2988936 Fri, 13 Nov 2009 04:00:17 +0100 2988936 http://www.medworm.com/index.php?rid=2988935&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900786-2 Renata Sano, Ida Annunziata, Annette Patterson, Simon Moshiach, Elida Gomero, Joseph Opferman, Michael Forte, Alessandra d'Azzo. Mitochondria-associated ER membranes, or MAMs, define the sites of endoplasmic reticulum/mitochondria juxtaposition that control Ca2+ flux between these organelles. We found that in a m.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=2988935 Fri, 13 Nov 2009 04:00:17 +0100 2988935 http://www.medworm.com/index.php?rid=2988934&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900690-X Hyungjin Kim, Ho-Chou Tu, Decheng Ren, Osamu Takeuchi, John R. Jeffers, Gerard P. Zambetti, James J.-D. Hsieh, Emily H.-Y. Cheng. While activation of BAX/BAK by BH3-only molecules (BH3s) is essential for mitochondrial apoptosis, the underlying mechanisms remain unsettled. Here we demonstrate that BAX undergoes stepwise struc.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=2988934 Fri, 13 Nov 2009 04:00:17 +0100 2988934 http://www.medworm.com/index.php?rid=2988933&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900782-5 Florian A. Karreth, Gina M. DeNicola, Stephen P. Winter, David A. Tuveson. Activating B-Raf mutations that deregulate the MAPK pathway commonly occur in cancer. Whether additional proteins modulate the enzymatic activity of oncogenic B-Raf is unknown. Here we show that t.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=2988933 Fri, 13 Nov 2009 04:00:17 +0100 2988933 http://www.medworm.com/index.php?rid=2988932&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900783-7 Jing Shan, Wenhui Zhao, Wei Gu. The cyclin D1 proto-oncoprotein is a crucial regulator in cell-cycle progression, and aberrant overexpression of cyclin D1 is linked to tumorigenesis of many different cancer types. By screening u.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=2988932 Fri, 13 Nov 2009 04:00:17 +0100 2988932 http://www.medworm.com/index.php?rid=2988931&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900703-5 Sheng Gao, Claudio Alarcón, Gopal Sapkota, Sadia Rahman, Pan-Yu Chen, Nina Goerner, Maria J. Macias, Hediye Erdjument-Bromage, Paul Tempst, Joan Massagué. TGF-β induces phosphorylation of the transcription factors Smad2 and Smad3 at the C terminus as well as at an interdomain linker region. TGF-β-induced linker phosphorylation marks the activated Sm.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=2988931 Fri, 13 Nov 2009 04:00:17 +0100 2988931 http://www.medworm.com/index.php?rid=2988930&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900688-1 Benjamin Czech, Rui Zhou, Yaniv Erlich, Julius Brennecke, Richard Binari, Christians Villalta, Assaf Gordon, Norbert Perrimon, Gregory J. Hannon. Drosophila Argonaute-1 and Argonaute-2 differ in function and small RNA content. AGO2 binds to siRNAs, whereas AGO1 is almost exclusively occupied by microRNAs. MicroRNA duplexes are intrin.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=2988930 Fri, 13 Nov 2009 04:00:17 +0100 2988930 http://www.medworm.com/index.php?rid=2988929&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900687-X Katsutomo Okamura, Na Liu, Eric C. Lai. In Drosophila, miRNA strands are predominantly sorted into AGO1 to regulate seed-matched target transcripts, while their partner miRNA∗ strands are thought to be mostly degraded..... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=2988929 Fri, 13 Nov 2009 04:00:17 +0100 2988929 http://www.medworm.com/index.php?rid=2988928&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900777-1 Rongmin Chen, Aaron Schirmer, Yongjin Lee, Hyeongmin Lee, Vivek Kumar, Seung-Hee Yoo, Joseph S. Takahashi, Choogon Lee. Circadian rhythms in mammals are generated by a transcriptional negative feedback loop that is driven primarily by oscillations of PER and CRY, which inhibit their own transcriptional activators, .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=2988928 Fri, 13 Nov 2009 04:00:17 +0100 2988928 http://www.medworm.com/index.php?rid=2988927&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2809%2900785-0 John D. Norris, Ching-Yi Chang, Bryan M. Wittmann, Rebecca S. Kunder, Huaxia Cui, Daju Fan, James D. Joseph, Donald P. McDonnell. HOXB13 is a member of the homeodomain family of sequence-specific transcription factors and, together with the androgen receptor (AR), plays a critical role in the normal development of the prosta.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=2988927 Fri, 13 Nov 2009 04:00:17 +0100 2988927