MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Molecular Cell' source. Tue, 07 Feb 2012 08:49:00 +0100 http://www.medworm.com/index.php?rid=5657961&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2812%2900043-3 Laura A. Simmons Kovacs, Michael B. Mayhew, David A. Orlando, Yuanjie Jin, Qingyun Li, Chenchen Huang, Steven I. Reed, Sayan Mukherjee, Steven B. Haase. During embryonic cell cycles, B-cyclin-CDKs function as the core component of an autonomous oscillator. Current models for the cell-cycle oscillator in nonembryonic cells are slightly more complex.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5657961 Thu, 02 Feb 2012 00:00:00 +0100 5657961 http://www.medworm.com/index.php?rid=5657960&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2812%2900042-1 Alison J. Hanson, Heather A. Wallace, Tanner J. Freeman, R. Daniel Beauchamp, Laura A. Lee, Ethan Lee. A key event in Wnt signaling is conversion of TCF/Lef from a transcriptional repressor to an activator, yet how this switch occurs is not well understood. Here, we report an unanticipated role for.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5657960 Thu, 02 Feb 2012 00:00:00 +0100 5657960 http://www.medworm.com/index.php?rid=5657959&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2812%2900003-2 We report here that PKM2 locali.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5657959 Thu, 02 Feb 2012 00:00:00 +0100 5657959 http://www.medworm.com/index.php?rid=5636819&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900986-5 Purusharth Rajyaguru, Meipei She, Roy Parker. The formation of mRNPs controls the interaction of the translation and degradation machinery with individual mRNAs. The yeast Scd6 protein and its orthologs regulate translation and mRNA degradati.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5636819 Fri, 27 Jan 2012 00:00:00 +0100 5636819 http://www.medworm.com/index.php?rid=5636818&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2812%2900004-4 Armin M. Gamper, Xinxian Qiao, Jennifer Kim, Liyong Zhang, Michelle C. DeSimone, W. Kimryn Rathmell, Yong Wan. The transcription factor Krüppel-like factor 4 (KLF4) is an important regulator of cell-fate decision, including cell-cycle regulation, apoptosis, and stem cell renewal, and plays an ambivalent ro.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5636818 Fri, 27 Jan 2012 00:00:00 +0100 5636818 http://www.medworm.com/index.php?rid=5636817&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900949-X We report that transcription of the β-kary.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5636817 Fri, 27 Jan 2012 00:00:00 +0100 5636817 http://www.medworm.com/index.php?rid=5636816&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2901003-3 Thang Van Nguyen, Pornpimon Angkasekwinai, Hong Dou, Feng-Ming Lin, Long-Sheng Lu, Jinke Cheng, Y. Eugene Chin, Chen Dong, Edward T.H. Yeh. Small ubiquitin-like modifier (SUMO) modification has emerged as an important regulatory mechanism during embryonic development. However, it is not known whether SUMOylation plays a role in the de.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5636816 Fri, 27 Jan 2012 00:00:00 +0100 5636816 http://www.medworm.com/index.php?rid=5636815&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900951-8 Alain R. Bataille, Célia Jeronimo, Pierre-Étienne Jacques, Louise Laramée, Marie-Ève Fortin, Audrey Forest, Maxime Bergeron, Steven D. Hanes, François Robert. Transcription by RNA polymerase II (RNAPII) is coupled to mRNA processing and chromatin modifications via the C-terminal domain (CTD) of its largest subunit, consisting of multiple repeats of the .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5636815 Fri, 27 Jan 2012 00:00:00 +0100 5636815 http://www.medworm.com/index.php?rid=5636814&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900954-3 Timothy E. Audas, Mathieu D. Jacob, Stephen Lee. Cellular pathways are established and maintained by stochastic interactions of highly mobile molecules. The nucleolus plays a central role in the regulation of these molecular networks by capturin.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5636814 Fri, 27 Jan 2012 00:00:00 +0100 5636814 http://www.medworm.com/index.php?rid=5636813&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2812%2900036-6 Eva Madi Riising, Kristian Helin. In this issue, Mousavi et al. (2011) report a novel gene activation function of the H3K27 methyltransferase, Ezh1, in addition to its known role in transcriptional repression. (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5636813 Fri, 27 Jan 2012 00:00:00 +0100 5636813 http://www.medworm.com/index.php?rid=5636812&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2812%2900041-X Roshan M. Kumar, James J. Collins. Cells can make fate decisions in response to information from the environment. In this issue of Molecular Cell, Chen et al. (2012) describe how the design of a signal-processing pathway all.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5636812 Fri, 27 Jan 2012 00:00:00 +0100 5636812 http://www.medworm.com/index.php?rid=5636811&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2812%2900046-9 Kannanganattu V. Prasanth. In this issue of Molecular Cell,Audas et al. (2012) demonstrate that a class of stress-induced noncoding RNAs immobilizes proteins in the nucleolus in response to a specific stimulus. (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5636811 Fri, 27 Jan 2012 00:00:00 +0100 5636811 http://www.medworm.com/index.php?rid=5636810&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2901002-1 Woo Jae Kim, Miguel N. Rivera, Erik J. Coffman, Daniel A. Haber. WTX encodes a tumor suppressor, frequently inactivated in Wilms tumor, with both plasma membrane and nuclear localization. WTX has been implicated in β-catenin turnover, but its effect on n.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5636810 Thu, 26 Jan 2012 00:00:00 +0100 5636810 http://www.medworm.com/index.php?rid=5636809&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2901001-X Karin Öjemalm, Katrin K. Halling, IngMarie Nilsson, Gunnar von Heijne. α-helical integral membrane proteins critically depend on the correct insertion of their transmembrane α helices into the lipid bilayer for proper folding, yet a surprisingly large fraction of the.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5636809 Thu, 26 Jan 2012 00:00:00 +0100 5636809 http://www.medworm.com/index.php?rid=5636808&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2901000-8 Jennifer A. Fairley, Louise E. Mitchell, Tracy Berg, Niall S. Kenneth, Conrad von Schubert, Herman H.W. Silljé, René H. Medema, Erich A. Nigg, Robert J. White. Polo-like kinase Plk1 controls numerous aspects of cell-cycle progression. We show that it associates with tRNA and 5S rRNA genes and regulates their transcription by RNA polymerase III (pol III) .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5636808 Thu, 26 Jan 2012 00:00:00 +0100 5636808 http://www.medworm.com/index.php?rid=5636807&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900995-6 Catherine A. Cremona, Prabha Sarangi, Yan Yang, Lisa E. Hang, Sadia Rahman, Xiaolan Zhao. The cellular response to DNA damage employs multiple dynamic protein modifications to exert rapid and adaptable effects. Substantial work has detailed the roles of canonical checkpoint-mediated ph.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5636807 Thu, 26 Jan 2012 00:00:00 +0100 5636807 http://www.medworm.com/index.php?rid=5618289&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900998-1 Yan Huang, Wencheng Li, Xiao Yao, Qi-jiang Lin, Jing-wen Yin, Yan Liang, Monika Heiner, Bin Tian, Jingyi Hui, Gang Wang. Mediator complex is an integrative hub for transcriptional regulation. Here we show that Mediator regulates alternative mRNA processing via its MED23 subunit. Combining tandem affinity purificatio.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5618289 Thu, 19 Jan 2012 00:00:00 +0100 5618289 http://www.medworm.com/index.php?rid=5618288&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900997-X Monika S. Kowalczyk, Jim R. Hughes, David Garrick, Magnus D. Lynch, Jacqueline A. Sharpe, Jacqueline A. Sloane-Stanley, Simon J. McGowan, Marco De Gobbi, Mona Hosseini, Douglas Vernimmen, Jill M. Brown, Nicola E. Gray, Licio Collavin, Richard J. Gibbons, Jonathan Flint, Stephen Taylor, Veronica J. Buckle, Thomas A. Milne, William G. Wood, Douglas R. Higgs. A substantial amount of organismal complexity is thought to be encoded by enhancers which specify the location, timing, and levels of gene expression. In mammals there are more enhancers than prom.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5618288 Thu, 19 Jan 2012 00:00:00 +0100 5618288 http://www.medworm.com/index.php?rid=5618287&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900996-8 Stacie L. Bumgarner, Gregor Neuert, Benjamin F. Voight, Anna Symbor-Nagrabska, Paula Grisafi, Alexander van Oudenaarden, Gerald R. Fink. Mechanisms through which long intergenic noncoding RNAs (ncRNAs) exert regulatory effects on eukaryotic biological processes remain largely elusive. Most studies of these phenomena rely on methods.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5618287 Thu, 19 Jan 2012 00:00:00 +0100 5618287 http://www.medworm.com/index.php?rid=5595099&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900953-1 Adeline Vitaliano-Prunier, Anna Babour, Lucas Hérissant, Luciano Apponi, Thanasis Margaritis, Frank C.P. Holstege, Anita H. Corbett, Carole Gwizdek, Catherine Dargemont. Histone H2B ubiquitylation is a transcription-dependent modification that not only regulates nucleosome dynamics but also controls the trimethylation of histone H3 on lysine 4 by promoting ubiquit.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5595099 Fri, 13 Jan 2012 00:00:00 +0100 5595099 http://www.medworm.com/index.php?rid=5595098&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900992-0 Federico Lazzaro, Daniele Novarina, Flavio Amara, Danielle L. Watt, Jana E. Stone, Vincenzo Costanzo, Peter M. Burgers, Thomas A. Kunkel, Paolo Plevani, Marco Muzi-Falconi. The chemical identity and integrity of the genome is challenged by the incorporation of ribonucleoside triphosphates (rNTPs) in place of deoxyribonucleoside triphosphates (dNTPs) during replicatio.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5595098 Fri, 13 Jan 2012 00:00:00 +0100 5595098 http://www.medworm.com/index.php?rid=5595097&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900994-4 Joshua J. Gruber, Scott H. Olejniczak, Jeongsik Yong, Gaspare La Rocca, Gideon Dreyfuss, Craig B. Thompson. Ars2 is a component of the nuclear cap-binding complex that contributes to microRNA biogenesis and is required for cellular proliferation. Here, we expand on the repertoire of Ars2-dependent micro.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5595097 Fri, 13 Jan 2012 00:00:00 +0100 5595097 http://www.medworm.com/index.php?rid=5595096&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900958-0 Miki Jishage, Sohail Malik, Ulrich Wagner, Beatrix Uberheide, Yasushi Ishihama, Xiaopeng Hu, Brian T. Chait, Averell Gnatt, Bing Ren, Robert G. Roeder. Pol II(G) is a distinct form of RNA polymerase II that contains the tightly associated Gdown1 polypeptide (encoded by POLR2M). Unlike Pol II, Pol II(G) is highly dependent upon Mediator for.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5595096 Fri, 13 Jan 2012 00:00:00 +0100 5595096 http://www.medworm.com/index.php?rid=5595095&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900906-3 We present evidence that Gdown1, .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5595095 Fri, 13 Jan 2012 00:00:00 +0100 5595095 http://www.medworm.com/index.php?rid=5595094&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900907-5 Weimin Li, Rakesh S. Laishram, Zhe Ji, Christy A. Barlow, Bin Tian, Richard A. Anderson. BIK protein is an initiator of mitochondrial apoptosis, and BIK expression is induced by proapoptotic signals, including DNA damage. Here, we demonstrate that 3′ end processing and expressi.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5595094 Fri, 13 Jan 2012 00:00:00 +0100 5595094 http://www.medworm.com/index.php?rid=5595093&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900905-1 Nilkantha Sen, Bindu D. Paul, Moataz M. Gadalla, Asif K. Mustafa, Tanusree Sen, Risheng Xu, Seyun Kim, Solomon H. Snyder. Nuclear factor κB (NF-κB) is an antiapoptotic transcription factor. We show that the antiapoptotic actions of NF-κB are mediated by hydrogen sulfide (H2S) synthesized by cystathionine g.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5595093 Fri, 13 Jan 2012 00:00:00 +0100 5595093 http://www.medworm.com/index.php?rid=5595092&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900990-7 Lily C. Chao, Peter Tontonoz. SIRT1 is a phylogenetically conserved energy sensor. The molecular mechanisms that regulate its catalytic activity, however, are incompletely understood. Gerhart-Hines et al. (2011) have identifie.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5595092 Fri, 13 Jan 2012 00:00:00 +0100 5595092 http://www.medworm.com/index.php?rid=5595091&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900991-9 Aaron M. Robitaille, Michael N. Hall. In the December 23rd issue of Molecular Cell, Banko et al. (2011) describe a chemical genetic screen that identified 28 novel AMPKα2 direct substrates. A subset of these substrates comprise.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5595091 Fri, 13 Jan 2012 00:00:00 +0100 5595091 http://www.medworm.com/index.php?rid=5595090&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900988-9 Hocine W. Mankouri, Wai Kit Chu, Ian D. Hickson. In this issue, Moldovan et al. (2012) report the identification of PARI, a putative human ortholog of the yeast Srs2 protein, which potentially regulates homologous recombination repair via its ab.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5595090 Fri, 13 Jan 2012 00:00:00 +0100 5595090 http://www.medworm.com/index.php?rid=5595089&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900989-0 Joaquín M. Espinosa. In this issue of Molecular Cell, papers by the Price and Roeder labs reveal how the Gdown1 protein antagonizes the general transcription factor TFIIF during RNAPII initiation and elongation.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5595089 Fri, 13 Jan 2012 00:00:00 +0100 5595089 http://www.medworm.com/index.php?rid=5595088&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900999-3 Neil D. Perkins. The importance of parallel signaling pathways controlling NF-κB subunit posttranslational modifications is demonstrated by Sen et al. (2012), who reveal that RelA (p65) sulfhydration, at its highl.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5595088 Fri, 13 Jan 2012 00:00:00 +0100 5595088 http://www.medworm.com/index.php?rid=5595087&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900993-2 Alison M. Day, Jonathon D. Brown, Sarah R. Taylor, Jonathan D. Rand, Brian A. Morgan, Elizabeth A. Veal. Eukaryotic 2-Cys peroxiredoxins (Prx) are abundant antioxidant enzymes whose thioredoxin peroxidase activity plays an important role in protecting against oxidative stress, aging, and cancer. Para.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5595087 Thu, 12 Jan 2012 00:00:00 +0100 5595087 http://www.medworm.com/index.php?rid=5570502&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900957-9 Jing Zhang, Christophe Rouillon, Melina Kerou, Judith Reeks, Kim Brugger, Shirley Graham, Julia Reimann, Giuseppe Cannone, Huanting Liu, Sonja-Verena Albers, James H. Naismith, Laura Spagnolo, Malcolm F. White. The prokaryotic clusters of regularly interspaced palindromic repeats (CRISPR) system utilizes genomically encoded CRISPR RNA (crRNA), derived from invadi.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5570502 Thu, 05 Jan 2012 00:00:00 +0100 5570502 http://www.medworm.com/index.php?rid=5570501&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900956-7 Sarah Geisler, Lisa Lojek, Ahmad M. Khalil, Kristian E. Baker, Jeff Coller. Decapping represents a critical control point in regulating expression of protein coding genes. Here, we demonstrate that decapping also modulates expression of long noncoding RNAs (lncRNAs). Spec.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5570501 Thu, 05 Jan 2012 00:00:00 +0100 5570501 http://www.medworm.com/index.php?rid=5570500&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900955-5 Caryn R. Hale, Sonali Majumdar, Joshua Elmore, Neil Pfister, Mark Compton, Sara Olson, Alissa M. Resch, Claiborne V.C. Glover, Brenton R. Graveley, Rebecca M. Terns, Michael P. Terns. Small RNAs target invaders for silencing in the CRISPR-Cas pathways that protect bacteria and archaea from viruses and plasmids. The CRISPR RNAs (crRNAs) contain sequence elements acquired from in.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5570500 Thu, 05 Jan 2012 00:00:00 +0100 5570500 http://www.medworm.com/index.php?rid=5550793&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900952-X Weiguo Zhang, Serafin U. Colmenares, Gary H. Karpen. Centromeres are essential chromosomal regions required for kinetochore assembly and chromosome segregation. The composition and organization of centromeric nucleosomes containing the essential his.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5550793 Thu, 29 Dec 2011 00:00:00 +0100 5550793 http://www.medworm.com/index.php?rid=5550792&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900950-6 Jia-Yun Chen, Jia-Ren Lin, Karlene A. Cimprich, Tobias Meyer. Growth factors activate Ras, PI3K, and other signaling pathways. It is not well understood how these signals are translated by individual cells into a decision to proliferate or differentiate. Her.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5550792 Thu, 29 Dec 2011 00:00:00 +0100 5550792 http://www.medworm.com/index.php?rid=5535435&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Ffulltext%2FS1097-2765%2811%2900941-5 Zhao Zhang, Jia Xu, Birgit S. Koppetsch, Jie Wang, Cindy Tipping, Shengmei Ma, Zhiping Weng, William E. Theurkauf, Phillip D. Zamore. (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535435 Fri, 23 Dec 2011 00:00:00 +0100 5535435 http://www.medworm.com/index.php?rid=5535434&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Ffulltext%2FS1097-2765%2811%2900938-5 Yuezhou Chen, Zhenxiao Yang, Min Meng, Yue Zhao, Na Dong, Hongming Yan, Liping Liu, Mingxiao Ding, H. Benjamin Peng, Feng Shao. (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535434 Fri, 23 Dec 2011 00:00:00 +0100 5535434 http://www.medworm.com/index.php?rid=5535433&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900904-X Jing Yang, Kiran Kulkarni, Ioannis Manolaridis, Ziguo Zhang, Roger B. Dodd, Corine Mas-Droux, David Barford. The posttranslational modification of C-terminal CAAX motifs in proteins such as Ras, most Rho GTPases, and G protein γ subunits, plays an essential role in determining their subcellular localizat.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535433 Fri, 23 Dec 2011 00:00:00 +0100 5535433 http://www.medworm.com/index.php?rid=5535432&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900888-4 Guy Duval-Valentin, Michael Chandler. Transposable elements are important in genome dynamics and evolution. Bacterial insertion sequences (IS) constitute a major group in number and impact. Understanding their role in shaping genomes .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535432 Fri, 23 Dec 2011 00:00:00 +0100 5535432 http://www.medworm.com/index.php?rid=5535431&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900893-8 Lamia Wahba, Jeremy D. Amon, Douglas Koshland, Milena Vuica-Ross. Genome instability, a hallmark of cancer progression, is thought to arise through DNA double strand breaks (DSBs). Studies in yeast and mammalian cells have shown that DSBs and instability can occ.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535431 Fri, 23 Dec 2011 00:00:00 +0100 5535431 http://www.medworm.com/index.php?rid=5535430&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900889-6 Anne Helmrich, Monica Ballarino, Laszlo Tora. We show that the time required to transcribe human genes larger than 800 kb spans more than one complete cell cycle, while their transcription speed equals that of smaller genes. Independently of .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535430 Fri, 23 Dec 2011 00:00:00 +0100 5535430 http://www.medworm.com/index.php?rid=5535429&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900947-6 Edwin R. Smith, Chengqi Lin, Alexander S. Garrett, Janet Thornton, Nima Mohaghegh, Deqing Hu, Jessica Jackson, Anita Saraf, Selene K. Swanson, Christopher Seidel, Laurence Florens, Michael P. Washburn, Joel C. Eissenberg, Ali Shilatifard. Eleven-nineteen lysine-rich leukemia (ELL) participates in the super elongation complex (SEC) with the RNA polymerase II (Pol II) CTD kinase P-TEFb. SEC is a key regulator in the expression of .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535429 Fri, 23 Dec 2011 00:00:00 +0100 5535429 http://www.medworm.com/index.php?rid=5535428&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900887-2 Peter S. Brzovic, Clemens C. Heikaus, Leonid Kisselev, Robert Vernon, Eric Herbig, Derek Pacheco, Linda Warfield, Peter Littlefield, David Baker, Rachel E. Klevit, Steven Hahn. The structural basis for binding of the acidic transcription activator Gcn4 and one activator-binding domain of the Mediator subunit Gal11/Med15 was examined by NMR. Gal11 activator-binding domain.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535428 Fri, 23 Dec 2011 00:00:00 +0100 5535428 http://www.medworm.com/index.php?rid=5535427&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900945-2 Dominique Ray-Gallet, Adam Woolfe, Isabelle Vassias, Céline Pellentz, Nicolas Lacoste, Aastha Puri, David C. Schultz, Nikolay A. Pchelintsev, Peter D. Adams, Lars E.T. Jansen, Geneviève Almouzni. Establishment of a proper chromatin landscape is central to genome function. Here, we explain H3 variant distribution by specific targeting and dynamics of deposition involving the CAF-1 and HIRA .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535427 Fri, 23 Dec 2011 00:00:00 +0100 5535427 http://www.medworm.com/index.php?rid=5535426&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900940-3 Adam J.L. Cook, Zachary A. Gurard-Levin, Isabelle Vassias, Geneviève Almouzni. Proper genome packaging requires coordination of both DNA and histone metabolism. While histone gene transcription and RNA processing adequately provide for scheduled needs, how histone supply adj.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535426 Fri, 23 Dec 2011 00:00:00 +0100 5535426 http://www.medworm.com/index.php?rid=5535425&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900939-7 Robert J. Tomko, Mark Hochstrasser. The 26S proteasome, the central eukaryotic protease, comprises a core particle capped by a 19S regulatory particle (RP). The RP is divisible into base and lid subcomplexes. Lid biogenesis and inco.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535425 Fri, 23 Dec 2011 00:00:00 +0100 5535425 http://www.medworm.com/index.php?rid=5535424&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900892-6 David Matallanas, David Romano, Fahd Al-Mulla, Eric O'Neill, Waleed Al-Ali, Piero Crespo, Brendan Doyle, Colin Nixon, Owen Sansom, Matthias Drosten, Mariano Barbacid, Walter Kolch. K-Ras mutations are frequent in colorectal cancer (CRC), albeit K-Ras is the only Ras isoform that can elicit apoptosis. Here, we show that mutant K-Ras directly binds to the tumor suppressor RASS.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535424 Fri, 23 Dec 2011 00:00:00 +0100 5535424 http://www.medworm.com/index.php?rid=5535423&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900891-4 Taro Hitosugi, Jun Fan, Tae-Wook Chung, Katherine Lythgoe, Xu Wang, Jianxin Xie, Qingyuan Ge, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel, Georgia Z. Chen, Titus J. Boggon, Sagar Lonial, Haian Fu, Fadlo R. Khuri, Sumin Kang, Jing Chen. Many tumor cells rely on aerobic glycolysis instead of oxidative phosphorylation for their continued proliferation and survival. Myc and HIF-1 are believed to promote such a metabolic switch by, i.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535423 Fri, 23 Dec 2011 00:00:00 +0100 5535423 http://www.medworm.com/index.php?rid=5535422&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900944-0 Zachary Gerhart-Hines, John E. Dominy, Sharon M. Blättler, Mark P. Jedrychowski, Alexander S. Banks, Ji-Hong Lim, Helen Chim, Steven P. Gygi, Pere Puigserver. The NAD+-dependent deacetylase SIRT1 is an evolutionarily conserved metabolic sensor of the Sirtuin family that mediates homeostatic responses to certain physiological stresses such as .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535422 Fri, 23 Dec 2011 00:00:00 +0100 5535422 http://www.medworm.com/index.php?rid=5535421&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900942-7 Catherine J. Potenski, Hannah L. Klein. RNA:DNA hybrids in the genome are constantly being generated as a by-product of transcription; in this issue, two papers, from Helmrich et al. (2011) and Wahba et al. (2011), provide insight into .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535421 Fri, 23 Dec 2011 00:00:00 +0100 5535421 http://www.medworm.com/index.php?rid=5535420&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900943-9 Almut Schulze, Julian Downward. In this issue of Molecular Cell, Hitosugi et al. (2011) show that the switch from oxidative phosphorylation to glycolysis in cancer cells is regulated by tyrosine phosphorylation of PDHK1. (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535420 Fri, 23 Dec 2011 00:00:00 +0100 5535420 http://www.medworm.com/index.php?rid=5535419&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900946-4 Triona Ni Chonghaile, Anthony Letai. Much deliberation surrounds how the two homeostatic pathways, autophagy and apoptosis, converge; in the December 9 issue of Molecular Cell, Rubinstein et al. (2011) identify a proapoptotic .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535419 Fri, 23 Dec 2011 00:00:00 +0100 5535419 http://www.medworm.com/index.php?rid=5535418&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Ffulltext%2FS1097-2765%2811%2900948-8 Aseem Z. Ansari, Marsha Rich Rosner, Julius Adler. (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535418 Fri, 23 Dec 2011 00:00:00 +0100 5535418 http://www.medworm.com/index.php?rid=5535417&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900909-9 Kambiz Mousavi, Hossein Zare, A. Hongjun Wang, Vittorio Sartorelli. Polycomb group (PcG) proteins initiate the formation of repressed chromatin domains and regulate developmental gene expression. A mammalian PcG protein, enhancer of zeste homolog 2 (Ezh2), trigger.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535417 Thu, 22 Dec 2011 00:00:00 +0100 5535417 http://www.medworm.com/index.php?rid=5535416&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900908-7 Mo Liu, Dung-Fang Lee, Chun-Te Chen, Chia-Jui Yen, Long-Yuan Li, Hong-Jen Lee, Chun-Ju Chang, Wei-Chao Chang, Jung-Mao Hsu, Hsu-Ping Kuo, Weiya Xia, Yongkun Wei, Pei-Chun Chiu, Chao-Kai Chou, Yi Du, Debanjan Dhar, Michael Karin, Chung-Hsuan Chen, Mien-Chie Hung. Proinflammatory cytokine TNFα plays critical roles in promoting malignant cell proliferation, angiogenesis, and tumor metastasis in many cancers. However, the mechanism of TNFα-mediated tumor deve.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5535416 Thu, 22 Dec 2011 00:00:00 +0100 5535416 http://www.medworm.com/index.php?rid=5513625&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900901-4 Steven J. Petesch, John T. Lis. Eukaryotic cells possess many transcriptionally regulated mechanisms to alleviate the nucleosome barrier. Dramatic changes to the chromatin structure of Drosophila melanogaster Hsp70 gene l.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5513625 Thu, 15 Dec 2011 00:00:00 +0100 5513625 http://www.medworm.com/index.php?rid=5513624&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900900-2 Akiko Takahashi, Yoshinori Imai, Kimi Yamakoshi, Shinji Kuninaka, Naoko Ohtani, Shin Yoshimoto, Satoshi Hori, Makoto Tachibana, Emma Anderton, Takashi Takeuchi, Yoichi Shinkai, Gordon Peters, Hideyuki Saya, Eiji Hara. Both the DNA damage response (DDR) and epigenetic mechanisms play key roles in the implementation of senescent phenotypes, but very little is known about how these two mechanisms are integrated to.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5513624 Thu, 15 Dec 2011 00:00:00 +0100 5513624 http://www.medworm.com/index.php?rid=5484834&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900894-X Anna-Carina Jungkamp, Marlon Stoeckius, Desirea Mecenas, Dominic Grün, Guido Mastrobuoni, Stefan Kempa, Nikolaus Rajewsky. Animal mRNAs are regulated by hundreds of RNA binding proteins (RBPs). The identification of RBP targets is crucial for understanding their function. A recent method, PAR-CLIP, uses photoreactive .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484834 Fri, 09 Dec 2011 00:00:00 +0100 5484834 http://www.medworm.com/index.php?rid=5484833&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900844-6 Franck Gallardo, Nancy Laterreur, Emilio Cusanelli, Faissal Ouenzar, Emmanuelle Querido, Raymund J. Wellinger, Pascal Chartrand. The telomerase, which is composed of both protein and RNA, maintains genome stability by replenishing telomeric repeats at the ends of chromosomes. Here, we use live-cell imaging to follow yeast t.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484833 Fri, 09 Dec 2011 00:00:00 +0100 5484833 http://www.medworm.com/index.php?rid=5484832&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900858-6 Natalia Gebert, Michael Gebert, Silke Oeljeklaus, Karina von der Malsburg, David A. Stroud, Bogusz Kulawiak, Christophe Wirth, René P. Zahedi, Pavel Dolezal, Sebastian Wiese, Oliver Simon, Agnes Schulze-Specking, Kaye N. Truscott, Albert Sickmann, Peter Rehling, Bernard Guiard, Carola Hunte, Bettina Warscheid, Martin van der Laan, Nikolaus Pfanner, Nils Wiedemann. The mitochondrial inner membrane harbors the complexes of the respiratory chain and translocase complexes for precursor proteins. We have identified a further subunit of the carrier translocase (T.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484832 Fri, 09 Dec 2011 00:00:00 +0100 5484832 http://www.medworm.com/index.php?rid=5484831&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900853-7 Hyunkyung Kim, Ji Min Lee, Gina Lee, Jinhyuk Bhin, Se Kyu Oh, Kyeongkyu Kim, Ki Eun Pyo, Jason S. Lee, Hwa Young Yim, Keun Il Kim, Daehee Hwang, Jongkyeong Chung, Sung Hee Baek. A critical component of the DNA damage response is the p53 tumor suppressor, and aberrant p53 function leads to uncontrolled cell proliferation and malignancy. Several molecules have been shown to.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484831 Fri, 09 Dec 2011 00:00:00 +0100 5484831 http://www.medworm.com/index.php?rid=5484830&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900860-4 Adam M. Schmitt, Clayton D. Crawley, Shijune Kang, David R. Raleigh, Xiaohong Yu, Joshua S. Wahlstrom, David J. Voce, Thomas E. Darga, Ralph R. Weichselbaum, Bakhtiar Yamini. The functional significance of the signaling pathway induced by O6-methylguanine (O6-MeG) lesions is poorly understood. Here, we identify the p50 subunit of NF-κB as a centra.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484830 Fri, 09 Dec 2011 00:00:00 +0100 5484830 http://www.medworm.com/index.php?rid=5484829&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900859-8 Hiroto Katoh, Zhaohui S. Qin, Runhua Liu, Lizhong Wang, Weiquan Li, Xiangzhi Li, Lipeng Wu, Zhanwen Du, Robert Lyons, Chang-Gong Liu, Xiuping Liu, Yali Dou, Pan Zheng, Yang Liu. Both H4K16 acetylation and H3K4 trimethylation are required for gene activation. However, it is still largely unclear how these modifications are orchestrated by transcriptional factors. Here, we .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484829 Fri, 09 Dec 2011 00:00:00 +0100 5484829 http://www.medworm.com/index.php?rid=5484828&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900851-3 Nerea Sanvisens, M. Carmen Bañó, Mingxia Huang, Sergi Puig. Ribonucleotide reductase (RNR) is an essential enzyme required for DNA synthesis and repair. Although iron is necessary for class Ia RNR activity, little is known about the mechanisms that control.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484828 Fri, 09 Dec 2011 00:00:00 +0100 5484828 http://www.medworm.com/index.php?rid=5484827&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900843-4 Joshua A. Arribere, Jennifer A. Doudna, Wendy V. Gilbert. Cell survival in changing environments requires appropriate regulation of gene expression, including posttranscriptional regulatory mechanisms. From reporter gene studies in glucose-starved yeast,.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484827 Fri, 09 Dec 2011 00:00:00 +0100 5484827 http://www.medworm.com/index.php?rid=5484826&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900852-5 Li Chen, Vassilia Balabanidou, David P. Remeta, Conceição A.S.A. Minetti, Athina G. Portaliou, Anastassios Economou, Charalampos G. Kalodimos. Protein-protein interactions mediate a vast number of cellular processes. Here, we present a regulatory mechanism in protein-protein interactions mediated by finely tuned structural instability an.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484826 Fri, 09 Dec 2011 00:00:00 +0100 5484826 http://www.medworm.com/index.php?rid=5484825&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900854-9 Lixin Wan, Weiguo Zou, Daming Gao, Hiroyuki Inuzuka, Hidefumi Fukushima, Anders H. Berg, Rebecca Drapp, Shavali Shaik, Dorothy Hu, Chantel Lester, Manuel Eguren, Marcos Malumbres, Laurie H. Glimcher, Wenyi Wei. The APC/Cdh1 E3 ubiquitin ligase plays an essential role in both mitotic exit and G1/S transition by targeting key cell-cycle regulators for destruction. There is mounting evidence indicating that.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484825 Fri, 09 Dec 2011 00:00:00 +0100 5484825 http://www.medworm.com/index.php?rid=5484824&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900899-9 Gianluca Varetti, Claudia Guida, Stefano Santaguida, Elena Chiroli, Andrea Musacchio. The spindle assembly checkpoint (SAC) restricts mitotic exit to cells that have completed chromosome-microtubule attachment. Cdc20 is a bifunctional protein. In complex with SAC proteins Mad2, Bub.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484824 Fri, 09 Dec 2011 00:00:00 +0100 5484824 http://www.medworm.com/index.php?rid=5484823&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900890-2 Assaf D. Rubinstein, Miriam Eisenstein, Yaara Ber, Shani Bialik, Adi Kimchi. Autophagy and apoptosis constitute important determinants of cell fate and engage in a complex interplay in both physiological and pathological settings. The molecular basis of this crosstalk is p.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484823 Fri, 09 Dec 2011 00:00:00 +0100 5484823 http://www.medworm.com/index.php?rid=5484822&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900902-6 Gencer Sancar, Cigdem Sancar, Britta Brügger, Nati Ha, Timo Sachsenheimer, Elan Gin, Simon Wdowik, Ingrid Lohmann, Felix Wieland, Thomas Höfer, Axel Diernfellner, Michael Brunner. The white-collar complex (WCC), the core transcription factor of the circadian clock of Neurospora, activates morning-specific expression of the transcription repressor CSP1. Newly synthesi.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484822 Fri, 09 Dec 2011 00:00:00 +0100 5484822 http://www.medworm.com/index.php?rid=5484821&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900898-7 S. Hocine, R.H. Singer. Using the MS2 system for labeling mRNA, in this issue, Gallardo et al. (2011) find that telomere lengthening depends on a stable accumulation of multiple telomerase complexes in late S phase and t.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484821 Fri, 09 Dec 2011 00:00:00 +0100 5484821 http://www.medworm.com/index.php?rid=5484820&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900896-3 Alexandra Seguin, Diane McVey Ward, Jerry Kaplan. In this issue of Molecular Cell, Sanvisens et al. (2011) report a new mechanism for regulation of yeast ribonucleotide reductase activity that occurs during iron deprivation. (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484820 Fri, 09 Dec 2011 00:00:00 +0100 5484820 http://www.medworm.com/index.php?rid=5484819&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900897-5 Luying Jia, Hongtao Yu. Cdh1 is a well-established activator of APC/C, a RING-type ubiquitin ligase. In this issue of Molecular Cell, Wan et al. (2011) report an APC/C-independent role of Cdh1 during development a.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484819 Fri, 09 Dec 2011 00:00:00 +0100 5484819 http://www.medworm.com/index.php?rid=5484818&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900903-8 Isaac Edery. In this issue of Molecular Cell, Sancar et al. (2011) show that a morning-induced transcriptional repressor with a phosphorylation-gated half-life is a key cog in driving evening gene expre.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484818 Fri, 09 Dec 2011 00:00:00 +0100 5484818 http://www.medworm.com/index.php?rid=5484817&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900895-1 George-Lucian Moldovan, Donniphat Dejsuphong, Mark I.R. Petalcorin, Kay Hofmann, Shunichi Takeda, Simon J. Boulton, Alan D. D'Andrea. Inappropriate homologous recombination (HR) causes genomic instability and cancer. In yeast, the UvrD family helicase Srs2 is recruited to sites of DNA replication by SUMO-modified PCNA, where it .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484817 Thu, 08 Dec 2011 00:00:00 +0100 5484817 http://www.medworm.com/index.php?rid=5484816&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900857-4 Sanjeevkumar R. Patel, Samina S. Bhumbra, Raghavendra S. Paknikar, Gregory R. Dressler. The repression of transcription, through the concerted actions of tissue specific DNA binding proteins, Polycomb repressor complexes, and DNA methylation, is essential for maintaining stem cell pl.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5484816 Thu, 08 Dec 2011 00:00:00 +0100 5484816 http://www.medworm.com/index.php?rid=5466768&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900856-2 Sylvain Egloff, Justyna Zaborowska, Clélia Laitem, Tamás Kiss, Shona Murphy. The carboxy-terminal domain (CTD) of the large subunit of RNA polymerase II (Pol II) comprises multiple heptapeptide repeats of the consensus Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. Reversible phospho.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5466768 Thu, 01 Dec 2011 00:00:00 +0100 5466768 http://www.medworm.com/index.php?rid=5466767&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900855-0 Max R. Banko, Jasmina J. Allen, Bethany E. Schaffer, Erik W. Wilker, Peiling Tsou, Jamie L. White, Judit Villén, Beatrice Wang, Sara R. Kim, Kei Sakamoto, Steven P. Gygi, Lewis C. Cantley, Michael B. Yaffe, Kevan M. Shokat, Anne Brunet. The energy-sensing AMP-activated protein kinase (AMPK) is activated by low nutrient levels. Functions of AMPK, other than its role in cellular metabolism, are just beginning to emerge. Here we use.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5466767 Thu, 01 Dec 2011 00:00:00 +0100 5466767 http://www.medworm.com/index.php?rid=5419797&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900816-1 Karen Jack, Cristian Bellodi, Dori M. Landry, Rachel O. Niederer, Arturas Meskauskas, Sharmishtha Musalgaonkar, Noam Kopmar, Olya Krasnykh, Alison M. Dean, Sunnie R. Thompson, Davide Ruggero, Jonathan D. Dinman. How pseudouridylation (Ψ), the most common and evolutionarily conserved modification of rRNA, regulates ribosome activity is poorly understood. Medically, Ψ is important because the rRNA Ψ synthas.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419797 Fri, 18 Nov 2011 00:00:00 +0100 5419797 http://www.medworm.com/index.php?rid=5419796&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900815-X Kaori K. Takai, Tatsuya Kibe, Jill R. Donigian, David Frescas, Titia de Lange. To prevent ATR activation, telomeres deploy the single-stranded DNA binding activity of TPP1/POT1a. POT1a blocks the binding of RPA to telomeres, suggesting that ATR is repressed through RPA exclu.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419796 Fri, 18 Nov 2011 00:00:00 +0100 5419796 http://www.medworm.com/index.php?rid=5419795&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900818-5 Jing Zhou, Kook Sun Ha, Arthur La Porta, Robert Landick, Steven M. Block. Transcriptional pausing by RNA polymerase (RNAP) plays an essential role in gene regulation. Pausing is modified by various elongation factors, including prokaryotic NusA, but the mechanisms under.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419795 Fri, 18 Nov 2011 00:00:00 +0100 5419795 http://www.medworm.com/index.php?rid=5419794&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900817-3 Nirmalya Sen, Yatendra Kumar Satija, Sanjeev Das. Metabolic stress results in p53 activation, which can trigger cell-cycle arrest, ROS clearance, or apoptosis. However, what determines the p53-mediated cell fate decision upon metabolic stress is .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419794 Fri, 18 Nov 2011 00:00:00 +0100 5419794 http://www.medworm.com/index.php?rid=5419793&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900813-6 Alex J. Kuo, Peggie Cheung, Kaifu Chen, Barry M. Zee, Mitomu Kioi, Josh Lauring, Yuanxin Xi, Ben Ho Park, Xiaobing Shi, Benjamin A. Garcia, Wei Li, Or Gozani. The histone lysine methyltransferase NSD2 (MMSET/WHSC1) is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. Howev.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419793 Fri, 18 Nov 2011 00:00:00 +0100 5419793 http://www.medworm.com/index.php?rid=5419792&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900814-8 Chunying Yang, Xi Tang, Xiaojing Guo, Yohei Niikura, Katsumi Kitagawa, Kemi Cui, Stephen T.C. Wong, Li Fu, Bo Xu. The ATM kinase plays a critical role in the maintenance of genetic stability. ATM is activated in response to DNA damage and is essential for cell-cycle checkpoints. Here, we report that ATM is ac.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419792 Fri, 18 Nov 2011 00:00:00 +0100 5419792 http://www.medworm.com/index.php?rid=5419791&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900812-4 Thomas Gonatopoulos-Pournatzis, Sianadh Dunn, Rebecca Bounds, Victoria H. Cowling. The 7-methylguanosine cap added to the 5′ end of mRNA is required for efficient gene expression in eukaryotes. In mammals, methylation of the guanosine cap is catalyzed by RNMT (RNA guanine-7 meth.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419791 Fri, 18 Nov 2011 00:00:00 +0100 5419791 http://www.medworm.com/index.php?rid=5419790&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900845-8 Zhao Zhang, Jia Xu, Birgit S. Koppetsch, Jie Wang, Cindy Tipping, Shengmei Ma, Zhiping Weng, William E. Theurkauf, Phillip D. Zamore. piRNAs guide PIWI proteins to silence transposons in animal germ cells. Reciprocal cycles of piRNA-directed RNA cleavage—catalyzed by the PIWI proteins Aubergine (Aub) and Argonaute3 (Ago3) in .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419790 Fri, 18 Nov 2011 00:00:00 +0100 5419790 http://www.medworm.com/index.php?rid=5419789&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900811-2 Brian Skaug, Jueqi Chen, Fenghe Du, Jin He, Averil Ma, Zhijian J. Chen. A20 is a potent anti-inflammatory protein that inhibits NF-κB, and A20 dysfunction is associated with autoimmunity and B cell lymphoma. A20 harbors a deubiquitination enzyme domain and can employ .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419789 Fri, 18 Nov 2011 00:00:00 +0100 5419789 http://www.medworm.com/index.php?rid=5419788&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900810-0 Dong Hoon Kang, Doo Jae Lee, Kyung Wha Lee, Yoon Sun Park, Joo Young Lee, Sang-Hee Lee, Young Jun Koh, Gou-Young Koh, Chulhee Choi, Dae-Yeul Yu, Jaesang Kim, Sang Won Kang. Cellular antioxidant enzymes play crucial roles in aerobic organisms by eliminating detrimental oxidants and maintaining the intracellular redox homeostasis. Therefore, the function of antioxidant.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419788 Fri, 18 Nov 2011 00:00:00 +0100 5419788 http://www.medworm.com/index.php?rid=5419787&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900849-5 Hyungsoo Kim, Maria C. Scimia, Deepti Wilkinson, Ramon D. Trelles, Malcolm R. Wood, David Bowtell, Andrew Dillin, Mark Mercola, Ze'ev A. Ronai. Defining the mechanisms underlying the control of mitochondrial fusion and fission is critical to understanding cellular adaptation to diverse physiological conditions. Here we demonstrate that hy.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419787 Fri, 18 Nov 2011 00:00:00 +0100 5419787 http://www.medworm.com/index.php?rid=5419786&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900848-3 Mario Cioce, Giovanni Blandino. In this issue of Molecular Cell, Sen et al. (2011) report the involvement of PGC1α in modulating the transcriptional activity of p53 in metabolically challenged cells. They provide importan.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419786 Fri, 18 Nov 2011 00:00:00 +0100 5419786 http://www.medworm.com/index.php?rid=5419785&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900846-X Teeru Bihani, Philip W. Hinds. In this issue of Molecular Cell, Yang et al. (2011) demonstrate that Aurora B phosphorylates ATM, leading to its mitotic activation and ability to phosphorylate Bub1 and regulate the spindl.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419785 Fri, 18 Nov 2011 00:00:00 +0100 5419785 http://www.medworm.com/index.php?rid=5419784&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900850-1 Srinivasa M. Srinivasula, Jonathan D. Ashwell. In this issue of Molecular Cell, Skaug et al. (2011) propose a polyubiquitin-dependent, noncatalytic mechanism by which the deubiquitinase A20 inhibits IκB kinase and NF-κB activation. (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419784 Fri, 18 Nov 2011 00:00:00 +0100 5419784 http://www.medworm.com/index.php?rid=5419783&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900847-1 Sean P. Cullen, Conor M. Henry, Seamus J. Martin. Much debate surrounds how prosurvival members of the BCL-2 family repress opening of the BAX/BAK channel to block apoptosis; in this issue Llambi et al. (2011) identify two modes of apoptosis inhi.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5419783 Fri, 18 Nov 2011 00:00:00 +0100 5419783 http://www.medworm.com/index.php?rid=5378295&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900770-2 Ying Liu, Huiling Tan, Hui Tian, Chunyang Liang, She Chen, Qinghua Liu. The effector of RNA interference (RNAi) is the RNA-induced silencing complex (RISC). C3PO promotes the activation of RISC by degrading the Argonaute2 (Ago2)-nicked passenger strand of duplex siRNA.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378295 Fri, 04 Nov 2011 00:00:00 +0100 5378295 http://www.medworm.com/index.php?rid=5378294&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900795-7 Wissam Assaily, Daniel A. Rubinger, Keith Wheaton, Yunping Lin, Weili Ma, Wanli Xuan, Lauren Brown-Endres, Katsuya Tsuchihara, Tak W. Mak, Samuel Benchimol. The p53 protein is activated by stress signals and exhibits both protective and death-promoting functions that are considered important for its tumor suppressor function. Emerging evidence points .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378294 Fri, 04 Nov 2011 00:00:00 +0100 5378294 http://www.medworm.com/index.php?rid=5378293&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900766-0 Natacha Le Moan, Daniel M. Houslay, Frank Christian, Miles D. Houslay, Katerina Akassoglou. Homeostatic control of oxygen availability allows cells to survive oxygen deprivation. Although the transcription factor hypoxia-inducible factor 1α (HIF-1α) is the main regulator of the hypoxic r.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378293 Fri, 04 Nov 2011 00:00:00 +0100 5378293 http://www.medworm.com/index.php?rid=5378292&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900768-4 Nobuo N. Noda, Kenji Satoo, Yuko Fujioka, Hiroyuki Kumeta, Kenji Ogura, Hitoshi Nakatogawa, Yoshinori Ohsumi, Fuyuhiko Inagaki. E1 enzymes activate ubiquitin-like proteins and transfer them to cognate E2 enzymes. Atg7, a noncanonical E1, activates two ubiquitin-like proteins, Atg8 and Atg12, and plays a crucial role in aut.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378292 Fri, 04 Nov 2011 00:00:00 +0100 5378292 http://www.medworm.com/index.php?rid=5378291&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900767-2 Asad M. Taherbhoy, Stephen W. Tait, Stephen E. Kaiser, Allison H. Williams, Alan Deng, Amanda Nourse, Michal Hammel, Igor Kurinov, Charles O. Rock, Douglas R. Green, Brenda A. Schulman. Atg7 is a noncanonical, homodimeric E1 enzyme that interacts with the noncanonical E2 enzyme, Atg3, to mediate conjugation of the ubiquitin-like protein (UBL) Atg8 during autophagy. Here we report.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378291 Fri, 04 Nov 2011 00:00:00 +0100 5378291 http://www.medworm.com/index.php?rid=5378290&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900806-9 Liliana Krasinska, Maria Rosa Domingo-Sananes, Orsolya Kapuy, Nikolaos Parisis, Bethany Harker, Gregory Moorhead, Michel Rossignol, Béla Novák, Daniel Fisher. Bistability of the Cdk1-Wee1-Cdc25 mitotic control network underlies the switch-like transitions between interphase and mitosis. Here, we show by mathematical modeling and experiments in Xenopu.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378290 Fri, 04 Nov 2011 00:00:00 +0100 5378290 http://www.medworm.com/index.php?rid=5378289&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900771-4 Hiroshi I. Suzuki, Mayu Arase, Hironori Matsuyama, Young Lim Choi, Toshihide Ueno, Hiroyuki Mano, Koichi Sugimoto, Kohei Miyazono. MicroRNAs (miRNAs) are versatile regulators of gene expression and undergo complex maturation processes. However, the mechanism(s) stabilizing or reducing these small RNAs remains poorly understoo.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378289 Fri, 04 Nov 2011 00:00:00 +0100 5378289 http://www.medworm.com/index.php?rid=5378288&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900789-1 Arnaud R. Krebs, Krishanpal Karmodiya, Marianne Lindahl-Allen, Kevin Struhl, Làszlò Tora. Histone acetyltransferase (HAT) complexes are coactivators that are important for transcriptional activation by modifying chromatin. Metazoan SAGA and ATAC are distinct multisubunits complexes tha.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378288 Fri, 04 Nov 2011 00:00:00 +0100 5378288 http://www.medworm.com/index.php?rid=5378287&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900779-9 Timothy W. Sikorski, Scott B. Ficarro, John Holik, TaeSoo Kim, Oliver J. Rando, Jarrod A. Marto, Stephen Buratowski. Single-stranded DNA-binding proteins play many roles in nucleic acid metabolism, but their importance during transcription remains unclear. Quantitative proteomic analysis of RNA polymerase II (RN.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378287 Fri, 04 Nov 2011 00:00:00 +0100 5378287 http://www.medworm.com/index.php?rid=5378286&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900774-X Fernando Garces, Laurence H. Pearl, Antony W. Oliver. Mammalian polynucleotide kinase 3′ phosphatase (PNK) plays a key role in the repair of DNA damage, functioning as part of both the nonhomologous end-joining (NHEJ) and base excision repair (BER) p.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378286 Fri, 04 Nov 2011 00:00:00 +0100 5378286 http://www.medworm.com/index.php?rid=5378285&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900805-7 We report the pur.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378285 Fri, 04 Nov 2011 00:00:00 +0100 5378285 http://www.medworm.com/index.php?rid=5378284&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900765-9 Simon Quenneville, Gaetano Verde, Andrea Corsinotti, Adamandia Kapopoulou, Johan Jakobsson, Sandra Offner, Ilaria Baglivo, Paolo V. Pedone, Giovanna Grimaldi, Andrea Riccio, Didier Trono. The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57, its cofactor KA.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378284 Fri, 04 Nov 2011 00:00:00 +0100 5378284 http://www.medworm.com/index.php?rid=5378283&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900804-5 Trent Fowler, Ranjan Sen, Ananda L. Roy. Primary response genes (PRGs) are a set of genes that are induced in response to both cell-extrinsic and cell-intrinsic signals and do not require de novo protein synthesis for their expression. T.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378283 Fri, 04 Nov 2011 00:00:00 +0100 5378283 http://www.medworm.com/index.php?rid=5378282&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900809-4 Sarah Bajan, Gyorgy Hutvagner. In this issue of Molecular Cell,Suzuki et al. (2011) present the intriguing finding that an RNAse known to play an important role in immunity regulates miRNA processing in cancer and inflam.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378282 Fri, 04 Nov 2011 00:00:00 +0100 5378282 http://www.medworm.com/index.php?rid=5378281&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900808-2 Manel Camps, Brandt F. Eichman. In this issue of Molecular Cell, Dango and Mosammaparast discover that the human oxidative demethylase ALKBH3 functions in complex with a DNA helicase to eliminate N3-methylcytosine .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378281 Fri, 04 Nov 2011 00:00:00 +0100 5378281 http://www.medworm.com/index.php?rid=5378280&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900807-0 Folami Y. Ideraabdullah, Marisa S. Bartolomei. In this issue of Molecular Cell, Quenneville et al. (2011) characterize the role of ZFP57 in the maintenance of DNA methylation at imprinting control regions (ICRs), revealing an allele-spe.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5378280 Fri, 04 Nov 2011 00:00:00 +0100 5378280 http://www.medworm.com/index.php?rid=5356929&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900760-X Fabien Llambi, Tudor Moldoveanu, Stephen W.G. Tait, Lisa Bouchier-Hayes, Jamshid Temirov, Laura L. McCormick, Christopher P. Dillon, Douglas R. Green. During apoptosis, the BCL-2 protein family controls mitochondrial outer membrane permeabilization (MOMP), but the dynamics of this regulation remain controversial. We employed chimeric proteins co.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5356929 Thu, 27 Oct 2011 00:00:00 +0100 5356929 http://www.medworm.com/index.php?rid=5332870&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900720-9 Shanshan Duan, Jeffrey R. Skaar, Shafi Kuchay, Alfredo Toschi, Naama Kanarek, Yinon Ben-Neriah, Michele Pagano. DEPTOR is a recently identified inhibitor of the mTOR kinase that is highly regulated at the posttranslational level. In response to mitogens, we found that DEPTOR was rapidly phosphorylated on th.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332870 Fri, 21 Oct 2011 00:00:00 +0100 5332870 http://www.medworm.com/index.php?rid=5332869&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900719-2 Yongchao Zhao, Xiufang Xiong, Yi Sun. DEPTOR, an inhibitor of mTORC1 and mTORC2, is degraded via ubiquitin-proteasome pathway by an unknown E3 ubiquitin ligase. Here we report that DEPTOR is a physiological substrate of SCFβTrCP (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332869 Fri, 21 Oct 2011 00:00:00 +0100 5332869 http://www.medworm.com/index.php?rid=5332868&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900722-2 Daming Gao, Hiroyuki Inuzuka, Meng-Kwang Marcus Tan, Hidefumi Fukushima, Jason W. Locasale, Pengda Liu, Lixin Wan, Bo Zhai, Y. Rebecca Chin, Shavali Shaik, Costas A. Lyssiotis, Steven P. Gygi, Alex Toker, Lewis C. Cantley, John M. Asara, J. Wade Harper, Wenyi Wei. The activities of both mTORC1 and mTORC2 are negatively regulated by their endogenous inhibitor, DEPTOR. As such, the abundance of DEPTOR is a critical determinant in the activity status of the mT.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332868 Fri, 21 Oct 2011 00:00:00 +0100 5332868 http://www.medworm.com/index.php?rid=5332867&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900721-0 Gen Matsumoto, Koji Wada, Misako Okuno, Masaru Kurosawa, Nobuyuki Nukina. Selective macroautophagy (autophagy) of ubiquitinated protein is implicated as a compensatory mechanism of the ubiquitin-proteasome system. p62/SQSTM1 is a key molecule managing autophagic clearan.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332867 Fri, 21 Oct 2011 00:00:00 +0100 5332867 http://www.medworm.com/index.php?rid=5332866&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900717-9 Inna S. Afonina, Graham A. Tynan, Susan E. Logue, Sean P. Cullen, Michael Bots, Alexander U. Lüthi, Emer P. Reeves, Noel G. McElvaney, Jan P. Medema, Ed C. Lavelle, Seamus J. Martin. Granzyme B is a cytotoxic lymphocyte-derived protease that plays a central role in promoting apoptosis of virus-infected target cells, through direct proteolysis and activation of constituents of .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332866 Fri, 21 Oct 2011 00:00:00 +0100 5332866 http://www.medworm.com/index.php?rid=5332865&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900759-3 Mark A. Umbarger, Esteban Toro, Matthew A. Wright, Gregory J. Porreca, Davide Baù, Sun-Hae Hong, Michael J. Fero, Lihua J. Zhu, Marc A. Marti-Renom, Harley H. McAdams, Lucy Shapiro, Job Dekker, George M. Church. We have determined the three-dimensional (3D) architecture of the Caulobacter crescentus genome by combining genome-wide chromatin interaction detection, live-cell imaging, and computationa.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332865 Fri, 21 Oct 2011 00:00:00 +0100 5332865 http://www.medworm.com/index.php?rid=5332864&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900758-1 Chih-Yung S. Lee, Tzu-Lan Yeh, Bridget T. Hughes, Peter J. Espenshade. Regulation of gene expression plays an integral role in adaptation of cells to hypoxic stress. In mammals, prolyl hydroxylases control levels of the central transcription factor hypoxia inducible .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332864 Fri, 21 Oct 2011 00:00:00 +0100 5332864 http://www.medworm.com/index.php?rid=5332863&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900757-X Tatyana Budkevich, Jan Giesebrecht, Roger B. Altman, James B. Munro, Thorsten Mielke, Knud H. Nierhaus, Scott C. Blanchard, Christian M.T. Spahn. Although the structural core of the ribosome is conserved in all kingdoms of life, eukaryotic ribosomes are significantly larger and more complex than their bacterial counterparts. The extent to w.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332863 Fri, 21 Oct 2011 00:00:00 +0100 5332863 http://www.medworm.com/index.php?rid=5332862&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900718-0 Hyeog Kang, Jeong-Yong Suh, Young-Sang Jung, Jae-Won Jung, Myung K. Kim, Jay H. Chung. In mammals, the Sirtuins are composed of seven Sir2 orthologs (Sirt1–7) with a conserved deacetylase core that utilizes NAD+ as a cofactor. Interestingly, the deacetylase core of.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332862 Fri, 21 Oct 2011 00:00:00 +0100 5332862 http://www.medworm.com/index.php?rid=5332861&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900716-7 Nikola Wagener, Markus Ackermann, Soledad Funes, Walter Neupert. The AAA+ family in eukaryotes has many members in various cellular compartments with a role in protein unfolding and degradation. We show that the mitochondrial AAA-ATPase Bcs1 has an unusual func.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332861 Fri, 21 Oct 2011 00:00:00 +0100 5332861 http://www.medworm.com/index.php?rid=5332860&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900762-3 Lei Li. In this issue, Pathania et al. (2011) report the involvement of BRCA1 in ultraviolet (UV)-damage response at stalled replication forks, which extends the function of BRCA1 beyond its established r.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332860 Fri, 21 Oct 2011 00:00:00 +0100 5332860 http://www.medworm.com/index.php?rid=5332859&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900763-5 Timothy F. Osborne. In this issue of Molecular Cell, Lee et al. (2011) report a novel mechanism for oxygen-sensing in S. pombe, whereby the 2-OG-Fe(II) dioxygenase Ofd protein regulates both the DNA-bin.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332859 Fri, 21 Oct 2011 00:00:00 +0100 5332859 http://www.medworm.com/index.php?rid=5332858&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900764-7 Jun Yoshino, Shin-ichiro Imai. In this issue of Molecular Cell, Hirschey et al. demonstrate that loss of the NAD+-dependent deacetylase SIRT3 and resultant mitochondrial protein hyperacetylation play a critica.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332858 Fri, 21 Oct 2011 00:00:00 +0100 5332858 http://www.medworm.com/index.php?rid=5332857&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900761-1 Allon M. Klein, Laura Lande-Diner. As scientists, we greatly benefit from discussing our work with our peers. Informal, unstructured interactions often yield highly creative feedback. With this in mind, we created a group that fost.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5332857 Fri, 21 Oct 2011 00:00:00 +0100 5332857 http://www.medworm.com/index.php?rid=5294842&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900682-4 Wenxing Liang, Arun Malhotra, Murray P. Deutscher. RNase R, an Escherichia coli exoribonuclease important for degradation of structured RNAs, increases 3- to 10-fold under certain stress conditions, due to an increased half-life for this us.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294842 Fri, 07 Oct 2011 00:00:00 +0100 5294842 http://www.medworm.com/index.php?rid=5294841&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900677-0 Alex C. Faesen, Annette M.G. Dirac, Anitha Shanmugham, Huib Ovaa, Anastassis Perrakis, Titia K. Sixma. The ubiquitin-specific protease USP7/HAUSP regulates p53 and MDM2 levels, and cellular localization of FOXO4 and PTEN, and hence is critically important for their role in cellular processes. Here .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294841 Fri, 07 Oct 2011 00:00:00 +0100 5294841 http://www.medworm.com/index.php?rid=5294840&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900713-1 Angeles Duran, Ramars Amanchy, Juan F. Linares, Jayashree Joshi, Shadi Abu-Baker, Aleksey Porollo, Malene Hansen, Jorge Moscat, Maria T. Diaz-Meco. The signaling adaptor p62 is a critical mediator of important cellular functions, owing to its ability to establish interactions with various signaling intermediaries. Here, we identify raptor as .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294840 Fri, 07 Oct 2011 00:00:00 +0100 5294840 http://www.medworm.com/index.php?rid=5294839&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900724-6 Joerg E. Braun, Eric Huntzinger, Maria Fauser, Elisa Izaurralde. miRNAs are posttranscriptional regulators of gene expression that associate with Argonaute and GW182 proteins to repress translation and/or promote mRNA degradation. miRNA-mediated mRNA degradatio.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294839 Fri, 07 Oct 2011 00:00:00 +0100 5294839 http://www.medworm.com/index.php?rid=5294838&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900678-2 Caroline Lemieux, Samuel Marguerat, Jennifer Lafontaine, Nicolas Barbezier, Jürg Bähler, Francois Bachand. General discard pathways eliminate unprocessed and irregular pre-mRNAs to control the quality of gene expression. In contrast to such general pre-mRNA decay, we describe here a nuclear pre-mRNA de.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294838 Fri, 07 Oct 2011 00:00:00 +0100 5294838 http://www.medworm.com/index.php?rid=5294837&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900685-X Ana-Maria Farcas, Pelin Uluocak, Wolfgang Helmhart, Kim Nasmyth. The contribution of DNA catenation to sister chromatid cohesion is unclear partly because it has never been observed directly within mitotic chromosomes. Differential sedimentation-velocity and ge.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294837 Fri, 07 Oct 2011 00:00:00 +0100 5294837 http://www.medworm.com/index.php?rid=5294836&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900687-3 André Franz, Michael Orth, Paul A. Pirson, Remi Sonneville, J. Julian Blow, Anton Gartner, Olaf Stemmann, Thorsten Hoppe. Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. In the licensing step of DNA replication, CDT-1 is loaded onto chromatin to subseq.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294836 Fri, 07 Oct 2011 00:00:00 +0100 5294836 http://www.medworm.com/index.php?rid=5294835&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900679-4 Malavika Raman, Courtney G. Havens, Johannes C. Walter, J. Wade Harper. Several proteins, including the replication licensing factor CDT1 and the histone methyltransferase SET8, are targeted for proteolysis during DNA replication and repair by the E3 ubiquitin ligase .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294835 Fri, 07 Oct 2011 00:00:00 +0100 5294835 http://www.medworm.com/index.php?rid=5294834&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900684-8 Danika M. Johnston, Yurii Sedkov, Svetlana Petruk, Kristen M. Riley, Miki Fujioka, James B. Jaynes, Alexander Mazo. The Drosophila ecdysone receptor (EcR/Usp) is thought to activate or repress gene transcription depending on the presence or absence, respectively, of the hormone ecdysone. Unexpectedly, we.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294834 Fri, 07 Oct 2011 00:00:00 +0100 5294834 http://www.medworm.com/index.php?rid=5294832&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900683-6 Xiaohan Yang, Wenhua Yu, Lei Shi, Luyang Sun, Jing Liang, Xia Yi, Qian Li, Yu Zhang, Fen Yang, Xiao Han, Di Zhang, Jie Yang, Zhi Yao, Yongfeng Shang. Histone acetyltransferases (HATs) are an essential regulatory component in chromatin biology. Unlike A-type HATs, which are found in the nucleus and utilize nucleosomal histones as substrates and .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294832 Fri, 07 Oct 2011 00:00:00 +0100 5294832 http://www.medworm.com/index.php?rid=5294831&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900686-1 Ashley M. Wood, Kevin Van Bortle, Edward Ramos, Naomi Takenaka, Margaret Rohrbaugh, Brian C. Jones, Keith C. Jones, Victor G. Corces. Insulators are multiprotein-DNA complexes thought to affect gene expression by mediating inter- and intrachromosomal interactions. Drosophila insulators contain specific DNA-binding protein.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294831 Fri, 07 Oct 2011 00:00:00 +0100 5294831 http://www.medworm.com/index.php?rid=5294830&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900714-3 Douglas R. Green, Andrew Oberst, Christopher P. Dillon, Ricardo Weinlich, Guy S. Salvesen. Caspase-8, FADD, and FLIP orchestrate apoptosis in response to death receptor ligation. Mysteriously however, these proteins are also required for normal embryonic development and immune cell prol.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294830 Fri, 07 Oct 2011 00:00:00 +0100 5294830 http://www.medworm.com/index.php?rid=5294829&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900715-5 Chris G. Proud. A recent study reveals that the scaffold protein p62 plays a role in linking nutritional cues (amino acids) to the activation of mammalian target of rapamycin complex 1 (mTORC1), a protein kinase .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294829 Fri, 07 Oct 2011 00:00:00 +0100 5294829 http://www.medworm.com/index.php?rid=5294828&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900725-8 Luis Aragón. In this issue of Molecular Cell, Farcas et al. (2011) demonstrate that intertwining between sister chromatids at metaphase is much more significant than previously thought and, remarkably, .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294828 Fri, 07 Oct 2011 00:00:00 +0100 5294828 http://www.medworm.com/index.php?rid=5294827&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900723-4 Harish N. Ramanathan, Yihong Ye. In this issue of Molecular Cell, Raman et al. (2011) and Franz et al. (2011) establish the AAA ATPase CDC-48/p97 as an essential regulator of eukaryotic DNA replication that coordinates the.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294827 Fri, 07 Oct 2011 00:00:00 +0100 5294827 http://www.medworm.com/index.php?rid=5294826&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900726-X Margarita Krivega, Ann Dean. In this issue of Molecular Cell, Wood et al. (2011) provide mechanistic insight into the regulation of insulators that helps explain how they can organize chromatin in a cell type-specific .... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5294826 Fri, 07 Oct 2011 00:00:00 +0100 5294826 http://www.medworm.com/index.php?rid=5271162&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900680-0 Ci Chu, Kun Qu, Franklin L. Zhong, Steven E. Artandi, Howard Y. Chang. Long noncoding RNAs (lncRNAs) are key regulators of chromatin state, yet the nature and sites of RNA-chromatin interaction are mostly unknown. Here we introduce Chromatin Isolation b.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5271162 Fri, 30 Sep 2011 00:00:00 +0100 5271162 http://www.medworm.com/index.php?rid=5271163&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900712-X Shailja Pathania, Jenna Nguyen, Sarah J. Hill, Ralph Scully, Guillaume O. Adelmant, Jarrod A. Marto, Jean Feunteun, David M. Livingston. BRCA1 contributes to the response to UV irradiation. Utilizing its BRCT motifs, it is recruited during S/G2 to UV-damaged sites in a DNA replication-dependent but nucleotide excision repair (NER)-.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5271163 Thu, 29 Sep 2011 00:00:00 +0100 5271163 http://www.medworm.com/index.php?rid=5235503&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900637-X Stéphane Bertani, Silvia Sauer, Eugene Bolotin, Frank Sauer. The epigenetic activator Mixed lineage leukemia 1 (MLL1) is paramount for embryonic development and hematopoiesis. Here, we demonstrate that the long, noncoding RNA (lncRNA) Mistral (Mir.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5235503 Fri, 16 Sep 2011 00:00:00 +0100 5235503 http://www.medworm.com/index.php?rid=5235502&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900639-3 Markus Meyer, Mireya Plass, Jorge Pérez-Valle, Eduardo Eyras, Josep Vilardell. Poor understanding of the spliceosomal mechanisms to select intronic 3′ ends (3′ss) is a major obstacle to deciphering eukaryotic genomes. Here, we discern the rules for global 3′ss selection in y.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5235502 Fri, 16 Sep 2011 00:00:00 +0100 5235502 http://www.medworm.com/index.php?rid=5235501&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900640-X Muyang Li, Wei Gu. Both p53 and Mdmx are ubiquitinated and degraded by the same E3 ligase Mdm2; interestingly, however, while p53 is rapidly degraded by Mdm2, Mdmx is a stable protein in most cancer cells. Thus, the.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5235501 Fri, 16 Sep 2011 00:00:00 +0100 5235501 http://www.medworm.com/index.php?rid=5235500&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900638-1 Shinpei Kawaoka, Natsuko Izumi, Susumu Katsuma, Yukihide Tomari. PIWI-interacting RNAs (piRNAs) are 23–30 nucleotides small RNAs that act with PIWI proteins to silence transposon activity in animal gonads. In contrast to microRNAs and small interfering R.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5235500 Fri, 16 Sep 2011 00:00:00 +0100 5235500 http://www.medworm.com/index.php?rid=5235499&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900641-1 Young-Kook Kim, Jinah Yeo, Minju Ha, Boseon Kim, V. Narry Kim. Mammalian microRNAs (miRNAs) are highly stable in most cell types, and their decay mechanism remains largely unknown. Here we report that some miRNAs degrade rapidly upon the loss of cell adhesion.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5235499 Fri, 16 Sep 2011 00:00:00 +0100 5235499 http://www.medworm.com/index.php?rid=5235498&cid=s_32067_171_f&fid=32067&url=http%3A%2F%2Fwww.cell.com%2Fmolecular-cell%2Fabstract%2FS1097-2765%2811%2900642-3 Olivia S. Rissland, Sue-Jean Hong, David P. Bartel. The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or downregulated in many types of can.... (Source: Molecular Cell) Molecular Cell journals http://www.medworm.com/rss/comments.php?id=5235498 Fri, 16 Sep 2011 00:00:00 +0100 5235498