Molecular Imaging and Biology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Molecular Imaging and Biology' source. Thu, 09 Feb 2012 16:56:52 +0100 Proceedings of the 2011 World Molecular Imaging Congress, San Diego, CA, USA, September 7-10, 2011 http://www.medworm.com/index.php?rid=5673923&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa32452q9k8q4vk4x%2F Content Type Journal ArticlePages 1-993DOI 10.1007/s11307-012-0543-5 Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5673923 Mon, 06 Feb 2012 19:37:34 +0100 5673923 Incongruity of Imaging Using Fluorescent 2-DG Conjugates Compared to 18F-FDG in Preclinical Cancer Models http://www.medworm.com/index.php?rid=5664269&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm34m3jwt1t26x123%2F Conclusions  These results suggest that conjugation of large bulky fluorophores to 2-DG disrupts the facilitated transport and retention of these probes in cells. Therefore, optical imaging of NIR 2-DG probes cannot substitute for 18F-FDG positron emission tomography imaging as a biomarker of tumor cell viability and metabolism. Content Type Journal ArticleCategory Brief ArticlePages 1-8DOI 10.1007/s11307-012-0545-3Authors Jen-Chieh Tseng, Lurie Family Imaging Center, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USAYuchuan Wang, Lurie Family Imaging Center, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USAPallab Banerjee, Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5664269 Fri, 03 Feb 2012 07:21:22 +0100 5664269 Structure–Activity Relationship and Preclinical Evaluation of Carbon-11-Labeled Ammonium Salts as PET–Myocardial Perfusion Imaging Agents http://www.medworm.com/index.php?rid=5656476&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0rwj374pm2401006%2F Conclusions  SAR studies of 11C-labeled ammonium salts suggest that both lipophilicity and charge density affect the performance of these compounds as MPI probes. In a swine model, the labeled lead successfully visualized the defect regions in the myocardium. The data presented call for the development of fluorine-18 analogues, to increase clinical impact. Content Type Journal ArticleCategory Research ArticlePages 1-12DOI 10.1007/s11307-011-0539-6Authors Ohad Ilovich, Cyclotron/Radiochemistry Unit/Nuclear Medicine Department, Hadassah Hebrew University Hospital, Jerusalem, 91120 IsraelGalith Abourbeh, Cyclotron/Radiochemistry Unit/Nuclear Medicine Department, Hadassah Hebrew University Hospital, Jerusalem, 91120 IsraelMoshe Bocher, Department of Medical Biophysics an... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5656476 Tue, 31 Jan 2012 07:06:07 +0100 5656476 Introduction to the Proceedings of the 2011 World Molecular Imaging Congress http://www.medworm.com/index.php?rid=5643832&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2551422005432537%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s11307-012-0544-4 Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5643832 Fri, 27 Jan 2012 17:56:43 +0100 5643832 Table of Contents: Proceedings of the 2011 World Molecular Imaging Congress http://www.medworm.com/index.php?rid=5643831&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2624g65370758162%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s11307-012-0542-6 Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5643831 Fri, 27 Jan 2012 17:56:43 +0100 5643831 Approach to Assessing Myocardial Perfusion in Rats Using Static [13N]-Ammonia Images and a Small-Animal PET http://www.medworm.com/index.php?rid=5643833&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr1730x676j303527%2F Conclusions  The straightforward procedure described here (similar to those commonly used in clinical routine) was sufficient to yield statistically significant perfusion differences between the treated and untreated animals despite the small sample size. Content Type Journal ArticleCategory Brief ArticlePages 1-5DOI 10.1007/s11307-011-0538-7Authors Juan José Vaquero, Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Avda. de la Universidad 30, 28911 Leganés, Madrid, SpainDong-Wei Gao, Center for Molecular and Functional Imaging, University of California San Francisco, 185 Berry Street, Suite 350, 94107 San Francisco, CA, USACarmen García-Villaba, Unidad de Medicina y Cirugía Experimental, Hospital General Universitario G... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5643833 Wed, 25 Jan 2012 18:07:46 +0100 5643833 Positron Emission Tomography of 64Cu-DOTA-Rituximab in a Transgenic Mouse Model Expressing Human CD20 for Clinical Translation to Image NHL http://www.medworm.com/index.php?rid=5593009&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv63267523w53322h%2F Conclusions  PET imaging with PETRIT in huCD20 transgenic mice provided human dosimetry data for eventual applications in non-Hodgkins lymphoma patients. Content Type Journal ArticleCategory Research ArticlePages 1-9DOI 10.1007/s11307-011-0537-8Authors Arutselvan Natarajan, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USAGayatri Gowrishankar, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USACarsten H. Nielsen, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USASen Wang, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USAAndrei Iagaru, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USAMichael L. Goris, Div... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5593009 Tue, 10 Jan 2012 06:40:56 +0100 5593009 Fully Automated Production of 11C-Doxepin for PET Imaging Histamine H1 Receptor http://www.medworm.com/index.php?rid=5593010&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7466462030806641%2F Conclusions  A simplified and reliable fully automated production of 11 C-doxepin for clinical use was developed, allowing the synthesis of the tracer with high yield using a cGMP-compliant module and procedure. The success of this approach could make the PET tracer 11 C-doxepin more accessible for clinical studies. Content Type Journal ArticleCategory Brief ArticlePages 1-7DOI 10.1007/s11307-011-0535-xAuthors Hancheng Cai, PET Center, Children’s Hospital of Michigan/Detroit Medical Center, 3901 Beaubien Boulevard, Detroit, MI 48201, USAThomas J. Mangner, PET Center, Children’s Hospital of Michigan/Detroit Medical Center, 3901 Beaubien Boulevard, Detroit, MI 48201, USAOtto Muzik, PET Center, Children’s Hospital of Michigan/Detroit Medical Center, 3901 Beaubi... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5593010 Sat, 07 Jan 2012 06:44:26 +0100 5593010 In Vivo Quantification of Tumor Receptor Binding Potential with Dual-Reporter Molecular Imaging http://www.medworm.com/index.php?rid=5556783&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9547956780161q55%2F Conclusions  By providing a fast and robust measure of receptor density in tumors, the presented methodology has powerful implications for improving choices in cancer intervention, evaluation, and monitoring, and can be scaled to the clinic with an imaging modality like SPECT. Content Type Journal ArticleCategory Research ArticlePages 1-9DOI 10.1007/s11307-011-0534-yAuthors Kenneth M. Tichauer, Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USAKimberley S. Samkoe, Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USAKristian J. Sexton, Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USAShannon K. Hextrum, Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USAHarold H. Yang, Thayer School of E... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5556783 Wed, 28 Dec 2011 06:54:27 +0100 5556783 The World Molecular Imaging Society (WMIS) http://www.medworm.com/index.php?rid=5556784&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg8837134376q4057%2F Content Type Journal ArticleCategory EditorialPages 1-3DOI 10.1007/s11307-011-0536-9Authors Robert J. Gillies, H Lee Moffitt Cancer Center and Research Institute, Cancer Ecology, Tampa, FL, USAJuri Gelovani, University of Texas, MD Anderson Cancer Center, Houston, TX, USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5556784 Wed, 28 Dec 2011 06:54:26 +0100 5556784 Erratum to: Labelling of Granulocytes by Phagocytic Engulfment with 64Cu-Labelled Chitosan-Coated Magnetic Nanoparticles http://www.medworm.com/index.php?rid=5542206&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb35l539204463497%2F Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s11307-011-0533-zAuthors Alessandro Pala, Department of Gynecology, Obstetrics and Urology, Laboratory of Biochemistry of Sexual Hormones, ‘Sapienza’ University of Rome, Rome, ItalyMauro Liberatore, Department of Radiological, Oncological and Anatomo-Pathological Sciences, ‘Sapienza’ University of Rome, Rome, ItalyPiera D’Elia, Department of Gynecology, Obstetrics and Urology, Laboratory of Biochemistry of Sexual Hormones, ‘Sapienza’ University of Rome, Rome, ItalyFabio Nepi, Department of Nuclear Medicine, Hammersmith Hospital, London, UKValentina Megna, Department of Radiological, Oncological and Anatomo-Pathological Sciences, ‘Sapienza’ University of Rome, Rome, ItalyMarco Mastantuono, Department of R... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5542206 Thu, 22 Dec 2011 06:44:35 +0100 5542206 Imaging Copper Metabolism Imbalance in Atp7b−/− Knockout Mouse Model of Wilson’s Disease with PET-CT and Orally Administered 64CuCl2 http://www.medworm.com/index.php?rid=5520341&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr704452774017764%2F Conclusions  PET-CT quantitative analysis demonstrated an increased level of 64Cu radioactivity in the liver of Atp7b −/− KO mice compared with that in the control C57BL WT mice, following oral administration of 64CuCl2 as a tracer. The results of this study suggest the feasibility and utility of PET-CT using orally administered 64CuCl2 as a tracer (64CuCl2-PET/CT) for functional imaging of copper metabolism imbalance in WD. Content Type Journal ArticleCategory Research ArticlePages 1-8DOI 10.1007/s11307-011-0532-0Authors Fangyu Peng, Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Hines Blvd, Dallas, TX 75390-8542, USASvetlana Lutsenko, Department of Physiology, Johns Hopkins University, Baltimore, MD, USAXiankai Sun, De... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5520341 Thu, 15 Dec 2011 06:43:07 +0100 5520341 Half-Time SPECT Acquisition with Resolution Recovery for Tc-MIBI SPECT Imaging in the Assessment of Hyperparathyroidism http://www.medworm.com/index.php?rid=5512419&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flv6071765w4877t8%2F Conclusion  Parathyroid MIBI SPECT can be performed using the collimator-detector response compensation reconstruction algorithm for only half of the scanning time without compromising significant diagnostic data. Content Type Journal ArticleCategory Research ArticlePages 1-5DOI 10.1007/s11307-011-0530-2Authors Ronen Bar, Department of Otolaryngology, Head and Neck Surgery, Rambam Health Care Campus, Haifa, IsraelKinga Przewloka, Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, IsraelRachel Karry, Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, IsraelAlex Frenkel, Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, IsraelAvishay Golz, Department of Otolaryngology, Head and Neck Surgery, Rambam Health Care Campus, Haifa,... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5512419 Wed, 14 Dec 2011 06:56:49 +0100 5512419 Pharmacodynamic Evaluation of Irinotecan Therapy by FDG and FLT PET/CT Imaging in a Colorectal Cancer Xenograft Model http://www.medworm.com/index.php?rid=5512420&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu114v3m7mu230415%2F Conclusions  FLT-PET may be a better method than FDG-PET for assessing treatment response to irinotecan. Changes in imaging occur before changes in tumor volume. Content Type Journal ArticleCategory Research ArticlePages 1-8DOI 10.1007/s11307-011-0529-8Authors Sarah R. Mudd, Translational Imaging and Biochemical Biomarkers, Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USAKimberley D. Holich, Translational Imaging and Biochemical Biomarkers, Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL, USAMartin J. Voorbach, Translational Imaging and Biochemical Biomarkers, Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, A... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5512420 Wed, 14 Dec 2011 06:56:47 +0100 5512420 Dual-Labeling Strategies for Nuclear and Fluorescence Molecular Imaging: A Review and Analysis http://www.medworm.com/index.php?rid=5512422&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy8n32007pg22v528%2F Abstract  Molecular imaging is used for the detection of biochemical processes through the development of target-specific contrast agents. Separately, modalities such as nuclear and near-infrared fluorescence (NIRF) imaging have been shown to non-invasively monitor disease. More recently, merging of these modalities has shown promise owing to their comparable detection sensitivity and benefited from the development of dual-labeled imaging agents. Dual-labeled agents hold promise for whole-body and intraoperative imaging and could bridge the gap between surgical planning and image-guided resection with a single, molecularly targeted agent. In this review, we summarized the literature for dual-labeled antibodies and peptides that have been developed and have highlighted key c... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5512422 Mon, 12 Dec 2011 17:06:28 +0100 5512422 Germinal Center Texture Entropy as Possible Indicator of Humoral Immune Response: Immunophysiology Viewpoint http://www.medworm.com/index.php?rid=5512421&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg886l134175p5544%2F Conclusions  Germinal center texture entropy may be a powerful indicator of humoral immune response. This study is one of the first to point out the potential scientific value of GLCM image texture analysis in lymphoid tissue cytoarchitecture evaluation. Lymphoid tissue texture analysis could become an important and affordable addition to the conventional immunophysiology techniques. Content Type Journal ArticleCategory Brief ArticlePages 1-7DOI 10.1007/s11307-011-0531-1Authors Igor Pantic, Institute of Medical Physiology, Faculty of Medicine, University of Belgrade, Višegradska 26/II, 11000 Belgrade, SerbiaSenka Pantic, Institute of Histology and Embryology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia Journal Molecular Imaging and BiologyOn... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5512421 Mon, 12 Dec 2011 17:06:28 +0100 5512421 99mTc-labeled Rituximab for Imaging B Lymphocyte Infiltration in Inflammatory Autoimmune Disease Patients http://www.medworm.com/index.php?rid=5473651&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd32775243621v430%2F Conclusion  Rituximab can be efficiently labelled with 99mTc with high labelling efficiency. The results suggest that this technique might be used to assess B lymphocyte infiltration in affected organs in patients with autoimmune diseases; this may provide a rationale for anti-CD20 therapies. Content Type Journal ArticleCategory Research ArticlePages 1-10DOI 10.1007/s11307-011-0527-xAuthors G. Malviya, Nuclear Medicine Department, Faculty of Medicine and Surgery, “Sapienza” University of Rome, Via di Grottarossa 1035, 00189 Rome, ItalyK. L. Anzola, Nuclear Medicine Unit, Clinica Colsanitas, Bogotà, ColombiaE. Podestà, Allergy, Clinical Immunology and Rheumatology Unit, Faculty of Medicine and Surgery, “Sapienza” University of Rome, Rome, ItalyB. Laganà, All... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5473651 Wed, 30 Nov 2011 09:19:22 +0100 5473651 Cryo-image Analysis of Tumor Cell Migration, Invasion, and Dispersal in a Mouse Xenograft Model of Human Glioblastoma Multiforme http://www.medworm.com/index.php?rid=5473652&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw51713562011706h%2F Conclusion  Cryo-imaging and software allow, for the first time, 3D, whole brain, microscopic characterization of a tumor from a particular cell line. LN-229 exhibits considerable dispersal along blood vessels, a characteristic of human tumors that limits treatment success. Content Type Journal ArticleCategory Research ArticlePages 1-12DOI 10.1007/s11307-011-0525-zAuthors Mohammed Q. Qutaish, Department of Biomedical Engineering, Case Western Reserve University, Room 319 Wickenden Bldg., 2071 Martin Luther King Jr. Drive, Cleveland, OH 44106-7207, USAKristin E. Sullivant, Department of Biomedical Engineering, Case Western Reserve University, Room 319 Wickenden Bldg., 2071 Martin Luther King Jr. Drive, Cleveland, OH 44106-7207, USASusan M. Burden-Gulley, Department of... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5473652 Tue, 29 Nov 2011 22:22:09 +0100 5473652 Labelling of Granulocytes by Phagocytic Engulfment with 64Cu-Labelled Chitosan-Coated Magnetic Nanoparticles http://www.medworm.com/index.php?rid=5428032&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7m44164j5v70x4x4%2F Conclusion  In our in vitro model, MNPs are taken up by granulocytes through phagocytosis, whereas previously described methods were based on the use of a chelating agent that permit Cu to cross the cell membrane. Moreover, the 64Cu-engulfed granulocytes showed a high stability of up to 80% of retained radioactivity after 24 h of incubation. Content Type Journal ArticleCategory Research ArticlePages 1-6DOI 10.1007/s11307-011-0526-yAuthors Alessandra Pala, Department of Gynecology, Obstetrics and Urology, Laboratory of Biochemistry of Sexual Hormones, ‘Sapienza’ University of Rome, Rome, ItalyMauro Liberatore, Department of Radiological, Oncological and Anatomo-Pathological Sciences, ‘Sapienza’ University of Rome, Rome, ItalyPiera D’Elia, Department of G... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5428032 Tue, 15 Nov 2011 06:47:36 +0100 5428032 Biodistribution and Radiation Dosimetry of the Serotonin 5-HT6 Ligand [11C]GSK215083 Determined from Human Whole-Body PET http://www.medworm.com/index.php?rid=5404731&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd18t72h0632vn123%2F Conclusion  The estimated radiation dose for [11C]GSK215083 is consistent with those for other neuroreceptor ligands labeled with carbon-11. The somewhat higher dose estimate for females compared to males may reflect the difference in observed residence times and representative differences in the male and female phantoms used for dosimetry calculations. Based on conventionally accepted dose limits, [11C]GSK215083 may be used for multiple PET scans in the same subject. Content Type Journal ArticleCategory Research ArticlePages 1-5DOI 10.1007/s11307-011-0523-1Authors Robert A. Comley, GlaxoSmithKline Clinical Imaging Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London, W12 0NN UKCristian Salinas, GlaxoSmithKline Clinical Imaging Centre, Imperial... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5404731 Fri, 11 Nov 2011 06:55:34 +0100 5404731 Comparative Analysis of Peptide p5 and Serum Amyloid P Component for Imaging AA Amyloid in Mice Using Dual-Isotope SPECT http://www.medworm.com/index.php?rid=5375294&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa1107q4318023020%2F Conclusions  Radiolabeled p5 is an effective amyloid-imaging radiotracer as compared to SAP in the murine model of amyloidosis and may be rapidly translated for imaging patients with visceral amyloidosis in the USA. Content Type Journal ArticleCategory Brief ArticlePages 1-6DOI 10.1007/s11307-011-0524-0Authors Jonathan S. Wall, Department of Radiology, University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN 37920-6999, USATina Richey, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USAAngela Williams, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920, USAAlan Stuckey, Department of Radiology, University of Tennessee Graduate School of Medicin... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5375294 Mon, 31 Oct 2011 17:01:27 +0100 5375294 Automated Bone Volume and Thickness Measurements in Small Animal Whole-Body MicroCT Data http://www.medworm.com/index.php?rid=5330601&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc534p32147727165%2F Conclusions  We come to the conclusion that the presented method allows to measure and visualize local bone volume and thickness in longitudinal data in an accurate and robust manner, proving that the automated tool is a fast and user friendly alternative to manual analysis. Content Type Journal ArticleCategory Research ArticlePages 1-11DOI 10.1007/s11307-011-0522-2Authors Martin Baiker, Division of Image Processing, Leiden University Medical Center, Leiden, The NetherlandsThomas J. A. Snoeks, Department of Endocrinology, Leiden University Medical Center, Leiden, The NetherlandsEric L. Kaijzel, Department of Endocrinology, Leiden University Medical Center, Leiden, The NetherlandsIvo Que, Department of Endocrinology, Leiden University Medical Center, Leiden, The Nether... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5330601 Thu, 13 Oct 2011 05:50:12 +0100 5330601 Molecular Imaging and Contrast Agent Database (MICAD): Evolution and Progress http://www.medworm.com/index.php?rid=5321506&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh564345838kww2g6%2F Abstract  The purpose of writing this review is to showcase the Molecular Imaging and Contrast Agent Database (MICAD; www.micad.nlm.nih.gov) to students, researchers, and clinical investigators interested in the different aspects of molecular imaging. This database provides freely accessible, current, online scientific information regarding molecular imaging (MI) probes and contrast agents (CA) used for positron emission tomography, single-photon emission computed tomography, magnetic resonance imaging, X-ray/computed tomography, optical imaging and ultrasound imaging. Detailed information on >1,000 agents in MICAD is provided in a chapter format and can be accessed through PubMed. Lists containing >4,250 unique MI probes and CAs published in peer-reviewed journals and... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5321506 Wed, 12 Oct 2011 05:43:19 +0100 5321506 Mouse Atlas Registration with Non-tomographic Imaging Modalities—a Pilot Study Based on Simulation http://www.medworm.com/index.php?rid=5310742&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F754564086h284265%2F Conclusions  The methodologies and evaluation presented in this study should provide helpful information for designing preclinical atlas-based anatomical data acquisition systems. Content Type Journal ArticleCategory Research ArticlePages 1-12DOI 10.1007/s11307-011-0519-xAuthors Hongkai Wang, Crump Institute of Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USADavid B. Stout, Crump Institute of Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USAArion F. Chatziioannou, Crump Institute of Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5310742 Sat, 08 Oct 2011 05:51:03 +0100 5310742 Glucosamine-Linked Near-Infrared Fluorescent Probes for Imaging of Solid Tumor Xenografts http://www.medworm.com/index.php?rid=5301835&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw36m60566n550163%2F Conclusion  Both cyp-GlcN and cyp-2GlcN NIRF probes exhibited good tumor-targeting properties in prostate cancer cell cultures and live mice. The cyp-2GlcN probe showed the highest uptake with good retention characteristics in vivo. The uptake of cyp-2GlcN and cyp-GlcN is likely mediated by glucosamine-recognizing transporters. The uptake mechanism is being explored further for developing cypate-glucosamine-based probes for in vivo imaging. Content Type Journal ArticleCategory Research ArticlePages 1-9DOI 10.1007/s11307-011-0520-4Authors Alexandru V. Korotcov, Molecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC, USAYunpeng Ye, Molecular Imaging Laboratory, Department of Radiology, Howard University, Washington, DC, USAYue Chen, Mo... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5301835 Wed, 05 Oct 2011 05:44:42 +0100 5301835 Orthotopic Expression of Noggin Protein in Cancer Cells Inhibits Human Lung Carcinoma Growth In Vivo http://www.medworm.com/index.php?rid=5233426&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Feq32p105022r5h42%2F Conclusion  The effect of Noggin protein expression is a consequence of inhibition of stromal and/or endothelial proliferation in vivo. Content Type Journal ArticleCategory Research ArticlePages 1-9DOI 10.1007/s11307-011-0518-yAuthors Hye-Won Kang, Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA, USASuresh Gupta, Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA, USAAlexei Bogdanov, Laboratory of Molecular Imaging Probes, Department of Radiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA, USA Journal Molecular Imaging and BiologyOnline ISSN 1860... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5233426 Tue, 13 Sep 2011 05:56:31 +0100 5233426 A Multimode Optical Imaging System for Preclinical Applications In Vivo: Technology Development, Multiscale Imaging, and Chemotherapy Assessment http://www.medworm.com/index.php?rid=5173926&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8019061262320485%2F Conclusions  This new system is versatile and can be optimized for various applications, of which cancer detection and targeted treatment are emphasized here. Content Type Journal ArticleCategory Research ArticlePages 1-12DOI 10.1007/s11307-011-0517-zAuthors Jae Youn Hwang, Minimally Invasive Surgical Technologies Institute and Department of Surgery, Cedars-Sinai Medical Center, 8700 Beverly Blvd. D6061, Los Angeles, CA 90048, USASebastian Wachsmann-Hogiu, NSF Center for Biophotonics, Science and Technology and Department of Pathology and Laboratory Medicine, University of California Davis, 2700 Stockton Blvd., Suite 1400, Sacramento, CA 95817, USAV. Krishnan Ramanujan, Minimally Invasive Surgical Technologies Institute and Department of Surgery, Cedars-Sinai Medical ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5173926 Sat, 27 Aug 2011 05:57:22 +0100 5173926 Imaging the Impact of Nox4 in Cycling Hypoxia-mediated U87 Glioblastoma Invasion and Infiltration http://www.medworm.com/index.php?rid=5173927&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy344hxq352273w58%2F Conclusions  Cycling hypoxia-induced ROS via Nox4 should be considered for therapeutic targeting of tumor cell invasion and infiltration in glioblastoma. Content Type Journal ArticleCategory Research ArticlePages 1-11DOI 10.1007/s11307-011-0516-0Authors Chia-Hung Hsieh, Graduate Institute of Basic Medical Science, China Medical University and Hospital, Taichung, TaiwanHao-Teng Chang, Graduate Institute of Molecular Systems Biomedicine, China Medical University, Taichung, TaiwanWu-Chung Shen, Department of Radiology, China Medical University and Hospital, Taichung, TaiwanWoei-Cherng Shyu, Department of Neurology, Center for Neuropsychiatry, China Medical University and Hospital, Taichung, TaiwanRen-Shyan Liu, Department of Nuclear Medicine, School of Medicine, National... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5173927 Fri, 26 Aug 2011 05:49:49 +0100 5173927 Integrin αvβ3 as a PET Imaging Biomarker for Osteoclast Number in Mouse Models of Negative and Positive Osteoclast Regulation http://www.medworm.com/index.php?rid=5155609&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu2075062510u073p%2F Conclusions  These data demonstrate that 64Cu-RGD localizes to areas in bone with increased osteoclast numbers and support the use of 64Cu-RGD as an imaging biomarker for osteoclast number that could be used to monitor osteoclast-related pathologies and their treatments. Content Type Journal ArticleCategory Research ArticlePages 1-9DOI 10.1007/s11307-011-0512-4Authors Alexander Zheleznyak, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USAThaddeus J. Wadas, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USAChristopher D. Sherman, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USAJessica M. Wilson, Mallinckrodt Institute of Radiol... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5155609 Fri, 19 Aug 2011 06:42:12 +0100 5155609 A Method to Rapidly and Accurately Compare the Relative Efficacies of Non-invasive Imaging Reporter Genes in a Mouse Model and its Application to Luciferase Reporters http://www.medworm.com/index.php?rid=5155610&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fan78pl2564g30312%2F Conclusions  Our findings contrast, in some cases, with conclusions drawn in prior comparisons of these reporter genes and demonstrate the need for a standardized method to evaluate alternative reporter genes in vivo. Our procedure can be adapted for reporter genes that utilize alternative imaging modalities (fluorescence, bioluminescence, MRI, SPECT, PET). Content Type Journal ArticleCategory Research ArticlePages 1-10DOI 10.1007/s11307-011-0515-1Authors Jose S. Gil, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 341 Boyer Hall, 611 Charles E Young Drive, Los Angeles, CA 90095-1570, USAHidevaldo B. Machado, Molecular Biology Institute, David Geffen School of Medicine, UCLA, 341 Boyer Hall, 611 Charles E Young Drive, Los Angeles, CA 90095-1570, U... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5155610 Thu, 18 Aug 2011 05:50:09 +0100 5155610 High Vascular Delivery of EGF, but Low Receptor Binding Rate Is Observed in AsPC-1 Tumors as Compared to Normal Pancreas http://www.medworm.com/index.php?rid=5155611&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb669h55224753ht5%2F Conclusions  Higher vascular delivery but low cellular association in the AsPC-1 tumor compared to the normal pancreas may be indicative of low receptor density due to low cellular content. This attribute of the AsPC-1 tumor may indicate one contributing cause of the difficulty in treating pancreatic tumors with cellular targeted agents. Content Type Journal ArticleCategory Research ArticlePages 1-8DOI 10.1007/s11307-011-0503-5Authors Kimberley S. Samkoe, Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USAKristian Sexton, Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USAKenneth M. Tichauer, Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USAShanno... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5155611 Wed, 17 Aug 2011 05:53:11 +0100 5155611 Importance of Quantification for the Analysis of PET Data in Oncology: Review of Current Methods and Trends for the Future http://www.medworm.com/index.php?rid=5137792&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj33j4tm6x4123p87%2F Abstract  In oncology, positron emission tomography (PET) is an important tool for tumour diagnosis and staging, assessment of response to treatment and evaluation of the pharmacokinetic properties and efficacy of new drugs. Despite its quantitative potential, however, in daily clinical practice PET is used almost exclusively with 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) and, in addition, [18F]FDG data are normally assessed visually or using simple indices as the standardised uptake value (SUV). After explaining why more sophisticated quantification methods can be useful in oncology, the paper reviews the approaches that are commonly used and those available but not routinely employed. Particular emphasis is addressed to the SUV, for its importance in clinical practice. Is... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5137792 Sat, 13 Aug 2011 06:07:46 +0100 5137792 Comparison of CT, PET, and PET/CT for Staging of Patients with Indolent Non-Hodgkin's Lymphoma: Statistical Errors in Fueger et al. (2009) http://www.medworm.com/index.php?rid=5106084&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe11354825074q828%2F Content Type Journal ArticlePages 1-2DOI 10.1007/s11307-011-0513-3Authors Larry R. White, School of Business, Lumpkin College of Business & Applied Sciences, Eastern Illinois University, Charleston, IL 61920, USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5106084 Thu, 04 Aug 2011 15:25:40 +0100 5106084 Cross-validation of Input Functions Obtained by H215O PET Imaging of Rat Heart and a Blood Flow-through Detector http://www.medworm.com/index.php?rid=5102756&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn27h8m1143711677%2F Conclusion  It is possible both to measure the input function from rat arteria femoralis during H2 15O PET imaging and to estimate the input function from rat H2 15O PET images, thereby facilitating the assessment of blood flow in organs visible in PET images. Content Type Journal ArticlePages 1-8DOI 10.1007/s11307-011-0511-5Authors Nobuyuki Kudomi, Turku PET Centre, University of Turku and Turku University Hospital, Turku, FinlandHannu Sipilä, Turku PET Centre, University of Turku and Turku University Hospital, Turku, FinlandAnu Autio, Turku PET Centre, University of Turku and Turku University Hospital, Turku, FinlandVesa Oikonen, Turku PET Centre, University of Turku and Turku University Hospital, Turku, FinlandHeidi Liljenbäck, Turku PET Centre, University of Tu... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5102756 Wed, 03 Aug 2011 05:42:11 +0100 5102756 The EIIAPA Chimeric Promoter for Tumor Specific Gene Therapy of Hepatoma http://www.medworm.com/index.php?rid=5076373&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx572461q41t94nr6%2F Conclusion  The chimeric EIIAPA is a potential candidate promoter for targeted imaging and gene therapy of HCC. Content Type Journal ArticlePages 1-10DOI 10.1007/s11307-011-0509-zAuthors Ya-Ju Hsieh, Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, TaiwanFu-Du Chen, TransWorld University, Yunlin, TaiwanChien-Chih Ke, Molecular and Genetic Imaging Core (NRPGM), National Yang-Ming University Medical School, Taipei, TaiwanHsin-Ell Wang, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, TaiwanChih-Jen Huang, Department of Radiation Oncology, Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanMing-Feng Hou, Department of General Surgery, Cancer Center, Kaohsiu... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5076373 Wed, 27 Jul 2011 18:48:22 +0100 5076373 Fast-Specific Tomography Imaging via Cerenkov Emission http://www.medworm.com/index.php?rid=5061491&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn577345r73661666%2F Conclusion  The proposed technique can quickly localize the mobility of radionuclides and uptake by organs, which provides an imaging methodology in oncology. Content Type Journal ArticlePages 1-7DOI 10.1007/s11307-011-0510-6Authors Jianghong Zhong, Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Room 931, Automation Building, No.95 Zhongguancun East Road, Beijing, 100190 ChinaChenghu Qin, Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Room 931, Automation Building, No.95 Zhongguancun East Road, Beijing, 100190 ChinaXin Yang, Intelligent Medical Research Center, Institute of Automation, Chinese Academy of Sciences, Room 931, Automation Building, No.95 Zhongguancun East Road, Beijing... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5061491 Sat, 23 Jul 2011 05:54:45 +0100 5061491 Quantification of Skeletal Blood Flow and Fluoride Metabolism in Rats using PET in a Pre-Clinical Stress Fracture Model http://www.medworm.com/index.php?rid=5061492&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F430041344w4n8672%2F Conclusions  The results shown here are consistent with previous studies, confirming this technique is suitable for evaluating the vascular response and mineral kinetics of osteogenic mechanical loading. Content Type Journal ArticlePages 1-7DOI 10.1007/s11307-011-0505-3Authors Ryan E. Tomlinson, Department of Orthopaedic Surgery, Washington University in St. Louis, 660 S. Euclid Ave., Campus Box 8233, St. Louis, MO 63110, USAMatthew J. Silva, Department of Orthopaedic Surgery, Washington University in St. Louis, 660 S. Euclid Ave., Campus Box 8233, St. Louis, MO 63110, USAKooresh I. Shoghi, Department of Radiology, Washington University in St. Louis, 510 S. Kingshighway Blvd., Campus Box 8225, St. Louis, MO 63110, USA Journal Molecular Imaging and BiologyOnline... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5061492 Fri, 22 Jul 2011 17:04:38 +0100 5061492 An Evaluation of 2-deoxy-2-[18F]Fluoro-D-Glucose and 3′-deoxy-3′-[18F]-Fluorothymidine Uptake in Human Tumor Xenograft Models http://www.medworm.com/index.php?rid=5048280&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx40617h525321k71%2F Conclusion  When evaluating imaging biomarkers in response to therapy, the choice of tumor model should take into account in vivo baseline radiotracer uptake, which can vary significantly between models. Content Type Journal ArticlePages 1-11DOI 10.1007/s11307-011-0504-4Authors Heather Keen, PHB Imaging Group, AstraZeneca, 19F22 Mereside, Alderley Park, Macclesfield, SK10 4TG UKBernd Pichler, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, Department of Preclinical Imaging and Radiopharmacy, University of Tübingen, Tübingen, GermanyDamaris Kukuk, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, Department of Preclinical Imaging and Radiopharmacy, University of Tübingen, Tübingen,... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5048280 Fri, 15 Jul 2011 05:52:06 +0100 5048280 Correlation of the Ga-68-Bombesin Analog Ga-68-BZH3 with Receptors Expression in Gliomas as Measured by Quantitative Dynamic Positron Emission Tomography (dPET) and Gene Arrays http://www.medworm.com/index.php?rid=5017801&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgx6642332r763056%2F Conclusions  The parameter k1 is correlated with the expression of BB2 based on gene array data. The quantitative analysis of the Ga-68-BZH3 kinetics can be used to predict the receptor expression of BB2 in gliomas based on k1 of the compartment analysis. However, this study is limited to the expression data on the mRNA level and further studies are needed to assess the correlation of gene expression on the protein level. Content Type Journal ArticlePages 1-8DOI 10.1007/s11307-011-0508-0Authors Ludwig G. Strauss, Medical PET Group—Biological Imaging [E060-1], CCU Nuclear Medicine, German Cancer Research Center, 69120 Heidelberg, GermanyDirk Koczan, Institute of Immunology, University of Rostock, Rostock, GermanyMarcel Seiz, Clinical Department of Neurosurgery, Medi... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5017801 Sat, 09 Jul 2011 06:22:55 +0100 5017801 Spectral Unmixing Imaging of Wavelength-Responsive Fluorescent Probes: An Application for the Real-Time Report of Amyloid Beta Species in Alzheimer’s Disease http://www.medworm.com/index.php?rid=5017802&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F854118t245j25028%2F Conclusion  This study provided evidence that signals processed by the spectral unmixing technique could be used as a real-time reporter of Aβ species loading in vivo and ex vivo. Content Type Journal ArticlePages 1-8DOI 10.1007/s11307-011-0501-7Authors Chongzhao Ran, Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Room 2301, Building 149, Charlestown, Boston, MA 02129, USAAnna Moore, Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Room 2301, Building 149, Charlestown, Boston, MA 02129, USA Journal Molecular Im... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5017802 Fri, 08 Jul 2011 05:50:53 +0100 5017802 Preclinical Evaluation of Radiolabeled DOTA-Derivatized Cyclic Minigastrin Analogs for Targeting Cholecystokinin Receptor Expressing Malignancies http://www.medworm.com/index.php?rid=5017803&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F27x518171w728256%2F Conclusions  Cyclic DOTA-minigastrin analogs are promising candidates for gastrin receptor scintigraphy and targeted radionuclide therapy. Content Type Journal ArticlePages 1-10DOI 10.1007/s11307-011-0506-2Authors Elisabeth von Guggenberg, Department of Nuclear Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, AustriaChristine Rangger, Department of Nuclear Medicine, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, AustriaJane Sosabowski, Centre for Molecular Oncology and Imaging, Barts and the London, Queen Mary’s School of Medicine and Dentistry, London, UKPeter Laverman, Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsJean-Claude Reubi, Department of Pathology, University of Be... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5017803 Wed, 06 Jul 2011 06:34:59 +0100 5017803 Microvessel Density But Not Neoangiogenesis Is Associated with 18F-FDG Uptake in Human Atherosclerotic Carotid Plaques http://www.medworm.com/index.php?rid=5017804&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0781313tv3817710%2F Conclusions  Neoangiogenesis is not associated with 18FDG uptake, whereas MVD and markers of vulnerability correlate with 18FDG uptake. The absence of correlation between markers of neoangiogenesis and 18FDG uptake suggests a temporal separation between the process of neoangiogenesis and inflammatory activity. Content Type Journal ArticlePages 1-9DOI 10.1007/s11307-011-0507-1Authors Sune Folke Pedersen, Cluster for Molecular Imaging, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, DenmarkMartin Graebe, Department of Vascular Surgery, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2200 Copenhagen, DenmarkAnne Mette Fisker Hag, Cluster for Molecular Imaging, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, DenmarkLiselotte Hoejgaard, Cluster ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=5017804 Wed, 06 Jul 2011 06:34:55 +0100 5017804 Multispectral Optoacoustic Tomography of Matrix Metalloproteinase Activity in Vulnerable Human Carotid Plaques http://www.medworm.com/index.php?rid=4997150&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Frwk434q25u316th1%2F Conclusions  We demonstrated, for the first time to our knowledge, the ability of MSOT to provide volumetric images of activatable molecular probe distribution deep within optically diffuse tissues. High-resolution mapping of MMP activity was achieved deep in the vulnerable plaque of intact human carotid specimens. This performance directly relates to pre-clinical screening applications in animal models and to clinical decision potential as it might eventually allow for highly specific visualization and staging of plaque vulnerability thus impacting therapeutic clinical decision making. Content Type Journal ArticlePages 1-9DOI 10.1007/s11307-011-0502-6Authors Daniel Razansky, Institute for Biological and Medical Imaging, Technische Universität München and Helmhol... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4997150 Fri, 01 Jul 2011 05:43:52 +0100 4997150 Albumin-Binding Domain Conjugate for Near-Infrared Fluorescence Lymphatic Imaging http://www.medworm.com/index.php?rid=4959254&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx272565216k14167%2F Conclusions  cABD-IRDye800 has utility for assessing lymphatic function in mouse models of human lymphatic disease and the potential for use in clinical diagnostic imaging of the lymphatic vasculature. Content Type Journal ArticlePages 1-14DOI 10.1007/s11307-011-0499-xAuthors Cynthia A. Davies-Venn, The Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, 1825 Pressler Street, SRB 330A, Houston, TX 77030, USABonnie Angermiller, The Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center, 1825 Pressler Street, SRB 330A, Houston, TX 77030, USANathaniel Wilganowski, The Center for Molecular Imaging, The Brown Foundation Institute... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4959254 Mon, 20 Jun 2011 14:22:28 +0100 4959254 RGD-Conjugated Human Ferritin Nanoparticles for Imaging Vascular Inflammation and Angiogenesis in Experimental Carotid and Aortic Disease http://www.medworm.com/index.php?rid=4901267&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv71q821j38586281%2F Conclusions  RGD-HFn enhances vascular molecular imaging by targeting both vascular inflammation and angiogenesis, and allows more comprehensive detection of high-risk atherosclerotic and aneurysmal vascular diseases. Content Type Journal ArticlePages 1-10DOI 10.1007/s11307-011-0495-1Authors Toshiro Kitagawa, Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Room H2157, Stanford, CA 94305–5233, USAHisanori Kosuge, Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Room H2157, Stanford, CA 94305–5233, USAMasaki Uchida, Department of Chemistry, Montana State University, 112 Chemistry and Biochemistry Building, Bozeman, MT 59715, USAMonica M. Dua, Division of Vascular Surgery, ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4901267 Fri, 03 Jun 2011 06:00:03 +0100 4901267 An Engineered Cysteine-Modified Diabody for Imaging Activated Leukocyte Cell Adhesion Molecule (ALCAM)-Positive Tumors http://www.medworm.com/index.php?rid=4901268&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc16723240h1423t4%2F Conclusions  Successful imaging with 64Cu-DOTA-CysDb in animal models suggests further investigation of ALCAM as an imaging biomarker is warranted. Content Type Journal ArticlePages 1-12DOI 10.1007/s11307-011-0500-8Authors Katelyn E. McCabe, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USABin Liu, Department of Anesthesia, University of California, San Francisco, San Francisco, CA, USAJames D. Marks, Department of Anesthesia, University of California, San Francisco, San Francisco, CA, USAJames S. Tomlinson, Division of Surgical Oncology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USAHong W... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4901268 Wed, 01 Jun 2011 06:00:31 +0100 4901268 Sigma-2 Receptor as Potential Indicator of Stem Cell Differentiation http://www.medworm.com/index.php?rid=4901269&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk127326221201l3v%2F Conclusion  These results suggest that σ2 receptors may serve to monitor stem cell differentiation in future experimental studies. Content Type Journal ArticlePages 1-11DOI 10.1007/s11307-011-0493-3Authors Jodi L. Haller, Frank Laboratory, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Clinical Center, Bldg. 10, Room BIN256, Bethesda, MD 20892, USAIrina Panyutin, Neumann Laboratory, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Clinical Center, Bldg. 10, Room BIN256, Bethesda, MD 20892, USAAneeka Chaudhry, Frank Laboratory, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Clinical Center, Bldg. 10, Room BIN256, Bethesda, MD 20892,... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4901269 Thu, 26 May 2011 05:44:59 +0100 4901269 Erratum to: Targeting Apoptosis for Optical Imaging of Infection http://www.medworm.com/index.php?rid=4901270&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh661721957k15782%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s11307-011-0498-yAuthors Mathew L. Thakur, Department of Radiology, Thomas Jefferson University, 1020 Locust Street, Suite 359-JAH, Philadelphia, PA 19107, USAKaijun Zhang, Department of Radiology, Thomas Jefferson University, 1020 Locust Street, Suite 359-JAH, Philadelphia, PA 19107, USABishnuhari Paudyal, Department of Radiology, Thomas Jefferson University, 1020 Locust Street, Suite 359-JAH, Philadelphia, PA 19107, USADevadhas Devakumar, Department of Radiology, Thomas Jefferson University, 1020 Locust Street, Suite 359-JAH, Philadelphia, PA 19107, USAMaria Y. Covarrubias, Bioimaging, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USAChang-po Chen, Department of Biochemistry Molecular Biology, Thomas Jefferson Un... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4901270 Mon, 23 May 2011 16:50:40 +0100 4901270 In Vivo Imaging of Lymph Node Migration of MNP- and 111In-Labeled Dendritic Cells in a Transgenic Mouse Model of Breast Cancer (MMTV-Ras) http://www.medworm.com/index.php?rid=4861214&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9070412768053276%2F Conclusions  MRI and SPECT imaging, by allowing in vivo dynamic monitoring of DC migration, could further the development and optimization of efficient anti-cancer vaccines. Content Type Journal ArticlePages 1-14DOI 10.1007/s11307-011-0496-0Authors Cristina Martelli, Department of Biomedical Sciences and Technologies, Section of Radiological Sciences, University of Milan, via di Rudinì 8, 20142 Milan, ItalyManuela Borelli, Department of Clinical Sciences, Chair of Immunology, University of Milan, via GB Grassi 74, Milan, ItalyLuisa Ottobrini, Department of Biomedical Sciences and Technologies, Section of Radiological Sciences, University of Milan, via di Rudinì 8, 20142 Milan, ItalyVeronica Rainone, Department of Clinical Sciences, Chair of Immunology, University of ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4861214 Fri, 20 May 2011 06:00:12 +0100 4861214 Molecular Imaging of Cell Death in an Experimental Model of Parkinson’s Disease with a Novel Apoptosis-Targeting Peptide http://www.medworm.com/index.php?rid=4839659&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg74ut6v142jg7782%2F Conclusions  We conclude that ApoPep-1 is the effective probe for imaging of apoptosis in the MPTP model and can be applied in brain diseases with apoptosis. Content Type Journal ArticlePages 1-9DOI 10.1007/s11307-011-0497-zAuthors Min-Jeong Lee, Department of Physiology, Kyungpook National University School of Medicine, 101 Dongin Dong 2 Ga, Jung Gu, Daegu, 700-422 Republic of KoreaKai Wang, Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, 101 Dongin Dong 2 Ga, Jung Gu, Daegu, 700-422 Republic of KoreaIn-San Kim, Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, 101 Dongin Dong 2 Ga, Jung Gu, Daegu, 700-422 Republic of KoreaByung-Heon Lee, Department of Biochemistry and Cell Bi... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4839659 Fri, 13 May 2011 05:43:07 +0100 4839659 Optimization of Coded Aperture Radioscintigraphy for Sentinel Lymph Node Mapping http://www.medworm.com/index.php?rid=4839660&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F86356r7h511360m7%2F Conclusions  This study lays the foundation for using CA collimation for SLN mapping, and also exposes several problems that require further investigation. Content Type Journal ArticlePages 1-10DOI 10.1007/s11307-011-0494-2Authors Hirofumi Fujii, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USAJohn D. Idoine, Department of Physics, Kenyon College, Gambier, OH 43022, USASylvain Gioux, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USARoberto Accorsi, Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USADavid R. Slochower, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USARichard C. Lanza, Department of Nuc... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4839660 Fri, 13 May 2011 05:43:05 +0100 4839660 In Vivo Photoactivation Without “Light”: Use of Cherenkov Radiation to Overcome the Penetration Limit of Light http://www.medworm.com/index.php?rid=4794184&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr4h79h0107318260%2F Conclusion  The proposed method may provide a very important option for in vivo photoactivation, in particular for activation of photosensitizers for photodynamic therapy and eventually for combining radioisotope therapy and photodynamic therapy. Content Type Journal ArticlePages 1-7DOI 10.1007/s11307-011-0489-zAuthors Chongzhao Ran, Molecular Imaging Laboratory, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Bldg.75, Charlestown, MA 02129, USAZhaoda Zhang, Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Bldg.75, Charlestown, MA 02129, USAJacob Hooker, Department of Radiology, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging,... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4794184 Tue, 03 May 2011 05:53:12 +0100 4794184 Targeting Apoptosis for Optical Imaging of Infection http://www.medworm.com/index.php?rid=4794185&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh457670810uuh725%2F Conclusions  Targeting PS presented on the outer leaflet of apoptotic or necrotic neutrophils as well as gram-positive microorganism with PS-specific NIR fluorophore provides a sensitive means of imaging infection. Literature indicates that NIR fluorophores can be detected 7–14 cm deep in tissue. This observation together with the excellent results and the continued development of versatile imaging devices could make optical imaging a simple, specific, and rapid modality for imaging infection. Content Type Journal ArticlePages 1-9DOI 10.1007/s11307-011-0490-6Authors Mathew L. Thakur, Department of Radiology, Thomas Jefferson University, 1020 Locust Street, Suite 359-JAH, Philadelphia, PA 19107, USAKaijun Zhang, Department of Radiology, Thomas Jefferson Univer... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4794185 Tue, 03 May 2011 05:53:11 +0100 4794185 Molecular Imaging, Principles and Practices http://www.medworm.com/index.php?rid=4744635&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx32m23517j747177%2F Content Type Journal ArticlePages 1-5DOI 10.1007/s11307-011-0492-4Authors Raymond E. Gibson, Molecular Imaging and Biology, 115 Stoney Ford Rd, Holland, PA 18966, USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4744635 Sat, 16 Apr 2011 05:56:28 +0100 4744635 18F-FDG PET/CT Imaging Detects Therapy Efficacy of Anti-EMMPRIN Antibody and Gemcitabine in Orthotopic Pancreatic Tumor Xenografts http://www.medworm.com/index.php?rid=4722948&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh752m23wgg7837um%2F Conclusions  These data provide support for clinical studies of anti-EMMPRIN therapy with gemcitabine for pancreatic cancer treatment. Content Type Journal ArticlePages 1-8DOI 10.1007/s11307-011-0491-5Authors Nemil Shah, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USAGuihua Zhai, Department of Radiology, University of Alabama at Birmingham, Birmingham, AL 35294, USAJoseph A. Knowles, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294, USACecil R. Stockard, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USAWilliam E. Grizzle, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USANaomi Fineberg, Department of Biostatistics, University o... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4722948 Fri, 15 Apr 2011 05:48:38 +0100 4722948 Initial Results with 11C-Acetate Positron Emission Tomography/Computed Tomography (PET/CT) in the Staging of Urinary Bladder Cancer http://www.medworm.com/index.php?rid=4722949&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F80138m8112416g52%2F Conclusions   11C-acetate has good sensitivity for bladder cancer and LN metastases. However, false positive uptake due to inflammation or granulomatous infection can occur, limiting the staging utility of 11C-acetate after prior intravesical BCG therapy. Content Type Journal ArticlePages 1-7DOI 10.1007/s11307-011-0488-0Authors Heiko Schöder, Department of Radiology, Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., Box 77, New York, NY 10065, USASeng C. Ong, Department of Radiology, Nuclear Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., Box 77, New York, NY 10065, USAVictor E. Reuter, Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USAShangde Cai, Department of Radiology, Radiochemistry Ser... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4722949 Thu, 14 Apr 2011 05:50:53 +0100 4722949 Prospective Evaluation of 99mTc MDP Scintigraphy, 18F NaF PET/CT, and 18F FDG PET/CT for Detection of Skeletal Metastases http://www.medworm.com/index.php?rid=4708657&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2503475256763386%2F Conclusion  Our prospective pilot-phase trial demonstrates superior image quality and evaluation of skeletal disease extent with 18F NaF PET/CT over 99mTc MDP scintigraphy and 18F FDG PET/CT. At the same time, 18F FDG PET detects extraskeletal disease that can significantly change disease management. As such, a combination of 18F FDG PET/CT and 18F NaF PET/CT may be necessary for cancer detection. Additional evaluation with larger cohorts is required to confirm these preliminary findings. Content Type Journal ArticlePages 1-8DOI 10.1007/s11307-011-0486-2Authors Andrei Iagaru, Department of Radiology, Division of Nuclear Medicine, Stanford University Medical Center, 300 Pasteur Dr, Room H-2200, Stanford, CA 94305, USAErik Mittra, Department of Radiology, Division of Nu... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4708657 Sat, 09 Apr 2011 05:53:38 +0100 4708657 Radiolabeling and In Vivo Imaging of Transplanted Renal Lineages Differentiated from Human Embryonic Stem Cells in Fetal Rhesus Monkeys http://www.medworm.com/index.php?rid=4708658&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh30612n2h0k0543v%2F Conclusions  These studies suggest that hES cells differentiated toward renal lineages can be effectively radiolabeled, transplanted into fetal monkey kidneys under ultrasound guidance, monitored with PET post-transplant, and identified by PET, BLI, PCR, FISH, and IHC post-tissue harvest. Content Type Journal ArticlePages 1-8DOI 10.1007/s11307-011-0487-1Authors Alice F. Tarantal, California National Primate Research Center, University of California, Pedrick and Hutchison Roads, Davis, CA 95616-8542, USAC. Chang I. Lee, California National Primate Research Center, University of California, Pedrick and Hutchison Roads, Davis, CA 95616-8542, USACynthia A. Batchelder, California National Primate Research Center, University of California, Pedrick and Hutchison Roads, Davi... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4708658 Sat, 09 Apr 2011 05:53:36 +0100 4708658 Tracer Level Electrophilic Synthesis and Pharmacokinetics of the Hypoxia Tracer [18F]EF5 http://www.medworm.com/index.php?rid=4669552&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff6n154t0340tpuv5%2F Conclusions  [18F]EF5 was synthesized by electrophilic labelling with high quality and high yields. Pharmacokinetics of [18F]EF5 was determined at trace level in several species. Our results suggest that the trace-level approach does not affect the biodistribution of [18F]EF5. Extensive metabolism was seen in mouse. Content Type Journal ArticlePages 1-8DOI 10.1007/s11307-011-0484-4Authors Olli Eskola, Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, FinlandTove J. Grönroos, Turku PET Centre, Medicity/PET Preclinical Imaging, University of Turku, Turku, FinlandSarita Forsback, Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, University of Turku, Turku, FinlandJohanna Tuomela, Department of Cell Biology and Anatomy, Ins... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4669552 Wed, 30 Mar 2011 06:01:45 +0100 4669552 Pharmacokinetics, Metabolism, Biodistribution, Radiation Dosimetry, and Toxicology of 18F-Fluoroacetate (18F-FACE) in Non-human Primates http://www.medworm.com/index.php?rid=4641573&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff30q521m2332176l%2F Conclusions  The effective dose and individual organ radiation absorbed doses from administration of a diagnostic dosage of 18F-FACE are acceptable. From a pharmacologic perspective, diagnostic dosages of 18F-FACE are non-toxic in primates and, therefore, could be safely administered to human patients for PET imaging. Content Type Journal ArticlePages 1-12DOI 10.1007/s11307-011-0485-3Authors Ryuichi Nishii, Department of Experimental Diagnostic Imaging, Center for Advanced Biomedical Imaging Research (CABIR), UT M. D. Anderson Cancer Center, 1881 East Road 3SCR2.3924, Houston, TX 77054, USAWilliam Tong, Department of Experimental Diagnostic Imaging, Center for Advanced Biomedical Imaging Research (CABIR), UT M. D. Anderson Cancer Center, 1881 East Road 3SCR2.3924, Hous... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4641573 Fri, 25 Mar 2011 05:50:03 +0100 4641573 Analysis of (R)- and (S)-[11C]rolipram Kinetics in Canine Myocardium for the Evaluation of Phosphodiesterase-4 with PET http://www.medworm.com/index.php?rid=4621444&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftq96u432xn4j4046%2F Conclusion  An important fraction (~65%) of the V T of (R)-[11C]rolipram at baseline reflects specific binding. Thus, the latter may be a useful index of phosphodiesterase-4 levels in canine myocardium. Content Type Journal ArticlePages 1-12DOI 10.1007/s11307-011-0482-6Authors Mireille Lortie, Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St., Ottawa, Ontario Canada K1Y 4W7Jean N. DaSilva, Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St., Ottawa, Ontario Canada K1Y 4W7Miran Kenk, Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St., Ottawa, Ontario Canada K1Y 4W7Stephanie Thorn, Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin St., Ottawa, Ontario Canada K1Y 4W7Darryl Davis, Cardiac PE... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4621444 Sat, 19 Mar 2011 06:48:35 +0100 4621444 First Experience with Clinical-Grade [18F]FPP(RGD)2: An Automated Multi-step Radiosynthesis for Clinical PET Studies http://www.medworm.com/index.php?rid=4580619&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F48qk07r350k64j4r%2F Conclusions  A reliable, routine, and automated radiosynthesis of clinical-grade [18F]FPP(RGD)2 was established. PET imaging in a healthy human volunteer illustrates that [18F]FPP(RGD)2 possesses desirable pharmacokinetic properties for clinical noninvasive imaging of αvβ3 expression. Further imaging studies using [18F]FPP(RGD)2 in patient volunteers are now under active investigation. Content Type Journal ArticlePages 1-8DOI 10.1007/s11307-011-0477-3Authors Frederick T. Chin, Molecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford University School of Medicine, Stanford, CA 94305, USABin Shen, Molecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program, Stanford U... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4580619 Fri, 11 Mar 2011 18:10:36 +0100 4580619 Ex Vivo Imaging of Pancreatic Beta Cells using a Radiolabeled GLP-1 Receptor Agonist http://www.medworm.com/index.php?rid=4580620&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg6k77n08vn044pm7%2F Conclusions   Ex vivo autoradiography results using [64Cu](Lys40(DOTA)NH2)Exendin-4 suggest that GLP-1R agonists based on Exendin-4 are attractive PET ligands for the in vivo determination of β-cell mass. Content Type Journal ArticlePages 1-9DOI 10.1007/s11307-011-0481-7Authors Brett M. Connolly, Department of Imaging, Merck Research Laboratories, West Point, PA 19486, USAAmy Vanko, Department of Imaging, Merck Research Laboratories, West Point, PA 19486, USAPaul McQuade, Department of Imaging, Merck Research Laboratories, West Point, PA 19486, USAIlonka Guenther, Department of Imaging, Merck Research Laboratories, West Point, PA 19486, USAXiangjun Meng, Department of Imaging, Merck Research Laboratories, West Point, PA 19486, USADaniel Rubins, Department of Imaging,... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4580620 Fri, 11 Mar 2011 06:52:33 +0100 4580620 Characterization of Human Osteoarthritic Cartilage Using Optical and Magnetic Resonance Imaging http://www.medworm.com/index.php?rid=4565260&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F03722703h3p0n273%2F Conclusions  The high T 1ρ and T 2 measurements suggest that there is a severe loss of proteoglycans with high water mobility in the damaged cartilage. The intense optical signals found in these specimens indicate the presence of active MMPs, and the positive correlation with T 1ρ measurements implicates MMP’s involvement in OA progression, characterized by a severe loss of proteoglycans in the cartilage matrix. The bimodal approach using optical and MR imaging may provide key molecular and macromolecular information of the disease pathway, offering insights toward the development of new tools for the early detection, treatment, and/or prevention of OA. Content Type Journal ArticlePages 1-8DOI 10.1007/s11307-011-0480-8Authors Ella F. Jones, Department of Rad... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4565260 Mon, 07 Mar 2011 17:04:51 +0100 4565260 Visualization of Copper Metabolism by 64CuCl2-PET http://www.medworm.com/index.php?rid=4565261&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx73656t776381342%2F Content Type Journal ArticlePages 1-3DOI 10.1007/s11307-011-0483-5Authors Hui Wang, Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USAXiaoyuan Chen, Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4565261 Mon, 07 Mar 2011 17:04:49 +0100 4565261 The Effect of Inhaled Gases on Ultrasound Contrast Agent Longevity In Vivo http://www.medworm.com/index.php?rid=4549320&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjt366134512572v5%2F Conclusions  Microbubble kinetics are closely associated with the driving gas for inhaled anesthesia. MA has the least effect and should be used when inhaled anesthesia is used. Furthermore, when animals are given multiple injections in the same session, microbubbles last longer with subsequent injections. Content Type Journal ArticlePages 1-7DOI 10.1007/s11307-011-0475-5Authors Malak Itani, Department of Radiology, UC San Diego, 200 W. Arbor Drive #8749, San Diego, CA 92103-8749, USARobert F. Mattrey, Department of Radiology, UC San Diego, 200 W. Arbor Drive #8749, San Diego, CA 92103-8749, USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4549320 Wed, 02 Mar 2011 07:50:41 +0100 4549320 Human Biodistribution and Dosimetry of the PET Radioligand [11C]Flumazenil (FMZ) http://www.medworm.com/index.php?rid=4549319&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj65152181h230616%2F Conclusion  On average, the administration of less than 790 MBq (21 mCi) of [11C]FMZ yields (no voiding model) an organ equivalent dose of under 50 mSv [the single dose limit for research studies under US regulations (21CFR361.1) to body organs other than blood forming organs, gonads or the lens of the eye] to all organs. Equivalent dose to the blood forming organs and gonads from a 790 MBq administered FMZ dose is well under the 30 mSv limit provided under 21CFR361.1. Additionally, administration of less than 1320 MBq (35.7 mCi) yields an effective dose [International Commission on Radiation Protection (ICRP) 60 tissue weighting scheme] of under 10 mSv, which is the ICRP IIb (minor to intermediate) risk category limit. Conten... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4549319 Wed, 02 Mar 2011 07:50:41 +0100 4549319 Evaluation of 64Cu Labeled GX1: A Phage Display Peptide Probe for PET Imaging of Tumor Vasculature http://www.medworm.com/index.php?rid=4549321&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx8pt14278640r561%2F Conclusion  Our studies demonstrate that 64Cu-DOTA-GX1 is a promising radiotracer for imaging tumor vasculature. Content Type Journal ArticlePages 1-10DOI 10.1007/s11307-011-0479-1Authors Kai Chen, Molecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, 2250 Alcazar Street, CSC 103, Los Angeles, CA 90033-9061, USAXilin Sun, Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Drive, Suite 1C14, Bethesda, MD 20892-2281, USAGang Niu, Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4549321 Tue, 01 Mar 2011 07:07:17 +0100 4549321 Positron Emission Tomography Imaging of Tumors Expressing the Human Chemokine Receptor CXCR4 in Mice with the Use of 64Cu-AMD3100 http://www.medworm.com/index.php?rid=4540023&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F271400243731114t%2F Conclusions  CXCR4 can be imaged in tumors using 64Cu-AMD3100. Dosimetry studies suggest that imaging in humans is feasible. We conclude that 64Cu-AMD3100 should be investigated as a potential agent for imaging and quantifying CXCR4 in tumors. Content Type Journal ArticlePages 1-9DOI 10.1007/s11307-010-0466-yAuthors Ido D. Weiss, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, 10 Center Drive, Room 11N111, Bethesda, MD 20892, USAOrit Jacobson, Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD 20892, USADale O. Kiesewetter, Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD 20892, US... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4540023 Wed, 23 Feb 2011 23:31:03 +0100 4540023 Labeling Protocols for In Vivo Tracking of Human Skeletal Muscle Cells (HSkMCs) by Magnetic Resonance and Bioluminescence Imaging http://www.medworm.com/index.php?rid=4511652&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwxn7318242817242%2F Conclusions  These protocols could be used to visualize new stem cells, in vivo and over time, in preclinical studies of cell-based treatments for myopathies of different etiologies. Content Type Journal ArticlePages 1-13DOI 10.1007/s11307-011-0474-6Authors Ilaria V. Libani, Department of Biomedical Sciences and Technologies, Section of Radiological Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, ItalyGiovanni Lucignani, Department of Biomedical Sciences and Technologies, Section of Radiological Sciences, University of Milan, Via di Rudinì 8, 20142 Milan, ItalyUmberto Gianelli, Pathology Unit, Department of Medicine, Surgery and Dentistry, University of Milan Medical School, IRCCS Ca’ Granda—Ospedale Maggiore Policlinico Foundation, Milan, ItalyAnna ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4511652 Sat, 19 Feb 2011 07:26:19 +0100 4511652 Positron Emission Tomography of Copper Metabolism in the Atp7b−/− Knock-out Mouse Model of Wilson’s Disease http://www.medworm.com/index.php?rid=4501098&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2k56t65j7476143h%2F Conclusions  Quantitative PET analysis demonstrates abnormal copper metabolism in the mouse model of WD with improved time–resolution. Human radiation dosimetry estimates obtained in this preclinical study encourage direct radiation dosimetry of 64CuCl2 in human subjects. The results suggest feasibility of utilizing 64CuCl2 as a tracer for noninvasive assessment of copper metabolism in WD with PET. Content Type Journal ArticlePages 1-9DOI 10.1007/s11307-011-0476-4Authors Fangyu Peng, Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8542, USASvetlana Lutsenko, Department of Physiology, Johns Hopkins University, Baltimore, MD USAXiankai Sun, Department of Radiology, University of Texas Southwestern Medic... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4501098 Thu, 17 Feb 2011 08:02:09 +0100 4501098 Evaluation of a Multi-pinhole Collimator for Imaging Small Animals with Different Sizes http://www.medworm.com/index.php?rid=4488781&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv5436n7525m7u6q6%2F Conclusions  This collimator allows flexible single pinhole and MPH SPECT imaging for rodents, achieving high resolution and detection efficiency with minimal image artifacts. Content Type Journal ArticlePages 1-10DOI 10.1007/s11307-011-0472-8Authors Greta S. P. Mok, Department of Electrical and Electronics Engineering, Faculty of Science and Technology, University of Macau, Taipa, MacauJianhua Yu, Division of Medical Imaging Physics, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287, USAYong Du, Division of Medical Imaging Physics, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD 21287, USAYuchuan Wang, Dana Farber Cancer Institute, Radio... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4488781 Mon, 14 Feb 2011 07:10:28 +0100 4488781 Targeted Multifunctional Multimodal Protein-Shell Microspheres as Cancer Imaging Contrast Agents http://www.medworm.com/index.php?rid=4449727&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5872v822844722j3%2F Conclusions  Preliminary results demonstrate multimodal contrast-enhanced imaging of these functionalized microsphere agents with MRI, MM-OCT, ultrasound imaging, and fluorescence microscopy, including in vivo tracking of the dynamics of these microspheres in real-time using a high-frequency ultrasound imaging system. These targeted oil-filled protein microspheres with the capacity for high drug-delivery loads offer the potential for local delivery of lipophilic drugs under image guidance. Content Type Journal ArticlePages 1-8DOI 10.1007/s11307-011-0473-7Authors Renu John, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, 61801 IL USAFreddy T. Nguyen, Beckman Institute for Advanced Sc... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4449727 Sat, 05 Feb 2011 06:42:59 +0100 4449727 Non-invasive Bioluminescence Imaging of Myoblast-Mediated Hypoxia-Inducible Factor-1 Alpha Gene Transfer http://www.medworm.com/index.php?rid=4418490&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F30283n4v6j206854%2F Conclusions  An objective evaluation of myoblast-mediated gene transfer in living mice can be performed by monitoring both the survival and the transgene expression of transplanted myoblasts using the techniques developed herein. Content Type Journal ArticlePages 1-9DOI 10.1007/s11307-011-0471-9Authors Olivier Gheysens, Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Division of Nuclear Medicine, Stanford University, The James H. Clark Center, 318 Campus Drive, East Wing, First Floor, Stanford, CA 94305-5427, USAIan Y. Chen, Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Division of Nuclear Medicine, Stanford University, The James H. Clark Center, 318 Campus Drive, East Wing, First Floor, Stanford, CA 94305-5427, USAMarti... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4418490 Wed, 26 Jan 2011 19:50:25 +0100 4418490 Fully Automated Preparation and Conjugation of N-Succinimidyl 4-[18F]Fluorobenzoate ([18F]SFB) with RGD Peptide Using a GE FASTlab™ Synthesizer http://www.medworm.com/index.php?rid=4418491&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj26363284m81612q%2F Conclusions  The formulated [18F]FPRGD2 was obtained without any operator manipulation with a d.c. yield of 13% ± 3% (n = 13) in 130 min, a radiochemical purity >98% and a specific activity of 140 ± 40 TBq/mmol. Content Type Journal ArticlePages 1-8DOI 10.1007/s11307-011-0470-xAuthors David Thonon, Cyclotron Research Center, Liege University, Sart-Tilman B. 30, 4000 Liege, BelgiumDavid Goblet, Cyclotron Research Center, Liege University, Sart-Tilman B. 30, 4000 Liege, BelgiumEve Goukens, Cyclotron Research Center, Liege University, Sart-Tilman B. 30, 4000 Liege, BelgiumGeoffroy Kaisin, Cyclotron Research Center, Liege University, Sart-Tilman B. 30, 4000 Liege, BelgiumJérôme Paris, Cyclotron Research Center, Liege University, Sart-Tilman B. ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4418491 Wed, 26 Jan 2011 19:50:24 +0100 4418491 Labeling of Luciferase/eGFP-Expressing Bone Marrow-Derived Stromal Cells with Fluorescent Micron-Sized Iron Oxide Particles Improves Quantitative and Qualitative Multimodal Imaging of Cellular Grafts In Vivo http://www.medworm.com/index.php?rid=4404914&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy0170087038727tk%2F Conclusions  This study describes an optimized labeling strategy for multimodal stem cell imaging resulting in improved quantitative and qualitative detection of cellular grafts. Content Type Journal ArticlePages 1-13DOI 10.1007/s11307-011-0469-3Authors Nathalie De Vocht, BioImaging Laboratory, University of Antwerp, Campus Groenenborger (CGB-V1.25), Groenenborgerlaan 171, 2020 Antwerp, BelgiumIrene Bergwerf, Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Campus Drie Eiken (CDE-T1.17), Universiteitsplein 1, 2610 Antwerp (Wilrijk), BelgiumGreetje Vanhoutte, BioImaging Laboratory, University of Antwerp, Campus Groenenborger (CGB-V1.25), Groenenborgerlaan 171, 2020 Antwerp, BelgiumJasmijn Daans, Labor... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4404914 Wed, 19 Jan 2011 09:32:51 +0100 4404914 Value of FDG PET/CT in Patients with Treated Ovarian Cancer and Raised CA125 Serum Levels http://www.medworm.com/index.php?rid=4360252&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkv3344347ug72201%2F Conclusion  PET/CT was able to detect active disease at relatively low levels of CA125, thereby facilitating the early diagnosis of recurrence or residual disease. Also in patients with low CA125 levels (<30), PET/CT had a relatively high detection rate (53%). According to our preliminary results, the use of FDG PET/CT in this setting is justified even with low serum CA125 levels. Content Type Journal ArticlePages 1-7DOI 10.1007/s11307-010-0468-9Authors Azahara Palomar, Department of Nuclear Medicine, Hospital General Ciudad Real, Ciudad Real, SpainCristina Nanni, Department of Nuclear Medicine, Policlinico Sant’Orsola-Malpighi, Bologna University, Via Massarenti 9, 40138 Bologna, ItalyPaolo Castellucci, Department of Nuclear Medicine, Policlinico Sant’Orsola-... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4360252 Sat, 15 Jan 2011 06:58:17 +0100 4360252 Qualitative and Quantitative Assessment of Metal Artifacts Arising from Implantable Cardiac Pacing Devices in Oncological PET/CT Studies: A Phantom Study http://www.medworm.com/index.php?rid=4317861&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgh44q34n3u684270%2F Conclusions  This study demonstrated that, depending on their elemental composition, different implantable cardiac pacing devices result in varying magnitudes of metal artifacts and thus pseudo-uptake on PET images. The MAR algorithm was not successful in compensating for underestimations which calls for a more efficient algorithm. The results showed that misalignments between PET and CT images render metal-related pseudo-uptake more severe. Content Type Journal ArticleDOI 10.1007/s11307-010-0467-xAuthors Mohammad R. Ay, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, IranAbolfazl Mehranian, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, IranMehrsima Ab... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4317861 Tue, 04 Jan 2011 07:41:19 +0100 4317861 Measuring Tumor Aggressiveness and Targeting Metastatic Lesions with Fluorescent pHLIP http://www.medworm.com/index.php?rid=4288346&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F24476510644n8l67%2F Conclusions  Tissue acidity can be detected by pHLIP peptide insertion and used to diagnose primary tumors, metastatic lesions, and lipid bodies in necrotic tissues. The ability of pHLIP to differentially bind metastatic and non-metastatic tumors may provide a new approach for evaluating cancer prognosis. Content Type Journal ArticleDOI 10.1007/s11307-010-0457-zAuthors Yana K. Reshetnyak, Physics Department, University of Rhode Island, Kingston, RI 02881, USALan Yao, Physics Department, University of Rhode Island, Kingston, RI 02881, USASida Zheng, Physics Department, University of Rhode Island, Kingston, RI 02881, USASergey Kuznetsov, Physics Department, University of Rhode Island, Kingston, RI 02881, USADonald M. Engelman, Department of Molecular Biophysics and Bio... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4288346 Thu, 23 Dec 2010 06:55:23 +0100 4288346 Chemical Imaging of Cardiac Cell and Tissue by Using Secondary Ion Mass Spectrometry http://www.medworm.com/index.php?rid=4271918&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F02u87218857145p5%2F Conclusion  The method provides information not only about cell and tissue morphology, shape, and condition but also about cellular membrane chemical composition and lateral distribution of biologically relevant molecules. Content Type Journal ArticleDOI 10.1007/s11307-010-0460-4Authors Monika Jerigova, International Laser Center, Ilkovicova 3, 84104 Bratislava, SlovakiaCsaba Biro, Faculty of Mathematics, Physics and Informatics, Comenius University, 84215 Bratislava, SlovakiaJana Kirchnerova, Faculty of Mathematics, Physics and Informatics, Comenius University, 84215 Bratislava, SlovakiaAlzbeta Chorvatova, International Laser Center, Ilkovicova 3, 84104 Bratislava, SlovakiaDusan Chorvat, International Laser Center, Ilkovicova 3, 84104 Bratislava, SlovakiaDusan Lorenc... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4271918 Thu, 16 Dec 2010 06:54:27 +0100 4271918 Molecular Imaging Techniques to Study the Biodistribution of Orally Administered 99mTc-Labelled Naive and Ligand-Tagged Nanoparticles http://www.medworm.com/index.php?rid=4271919&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyk8177145w753006%2F Conclusion  No evidence of translocation or distribution out of gastrointestinal tract was found. CD-NP moved significantly more slowly inside the gut than conventional NP, probably due to their physico-chemical structure that allows stronger interactions with the gut mucosa. Content Type Journal ArticleDOI 10.1007/s11307-010-0456-0Authors Paloma Areses, Radiopharmacy Unit, Department of Nuclear Medicine, Clínica Universidad de Navarra, University Clinic of Navarra, 31008 Pamplona, SpainMª Teresa Agüeros, Department of Pharmaceutics and Pharmaceutical Technology, University of Navarra, 31008 Pamplona, SpainGemma Quincoces, Radiopharmacy Unit, Department of Nuclear Medicine, Clínica Universidad de Navarra, University Clinic of Navarra, 31008 Pamplona, SpainMaría ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4271919 Thu, 16 Dec 2010 06:54:26 +0100 4271919 MicroPET Imaging of Integrin αvβ3 Expressing Tumors Using 89Zr-RGD Peptides http://www.medworm.com/index.php?rid=4271920&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F75161qq60w37786w%2F Conclusion  Efficient radiolabeling of peptides with an appropriate chelator such as Df-RGD with 89Zr was observed. The 89Zr radiolabeled peptides provided high-quality and high-resolution microPET images in xenograft models. 89Zr-Df-[FK]2-3PEG4 demonstrated the highest tumor-to-background ratio of the compounds tested. Preparation of 89Zr peptides to take advantage of the longer half-life is unwarranted due to the relatively rapid clearance from the tumor region of peptide tracers prepared for this study and the increased uptake in the bone of transchelated 89Zr with time (2.0 ± 0.36%ID/g, 24 h post-injection). Content Type Journal ArticleDOI 10.1007/s11307-010-0458-yAuthors Orit Jacobson, Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National I... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4271920 Thu, 16 Dec 2010 06:54:25 +0100 4271920 Dosimetry of 18F-Labeled Tyrosine Kinase Inhibitor SKI-249380, a Dasatinib-Tracer for PET Imaging http://www.medworm.com/index.php?rid=4264297&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxvl807780452p174%2F Conclusions  Animal-based human dose estimates support first-in-human testing of 18F-SKI-249380. Content Type Journal ArticleDOI 10.1007/s11307-010-0462-2Authors Mark P. S. Dunphy, Nuclear Medicine Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Room H-214B, Box 77, New York, NY 10065, USAPat Zanzonico, Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Room H-214B, Box 77, New York, NY 10065, USADarren Veach, Radiochemistry Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 77, Room H-214B, New York, NY 10065, USARomel Somwar, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 77, Room H-214B, New York, NY 10065, USANagavarakishore... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4264297 Wed, 15 Dec 2010 20:47:52 +0100 4264297 Clinical Utility of FDG–PET and PET/CT in Non-malignant Thoracic Disorders http://www.medworm.com/index.php?rid=4264296&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp8587113536674v1%2F This article reviews the current state of this very important application of FDG–PET imaging. Content Type Journal ArticleDOI 10.1007/s11307-010-0459-xAuthors Sandip Basu, Radiation Medicine Centre (BARC), Tata Memorial Hospital Annex, Parel, Bombay 400012, IndiaBabak Saboury, Division of Nuclear Medicine, Hospital of University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USATom Werner, Division of Nuclear Medicine, Hospital of University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USAAbass Alavi, Division of Nuclear Medicine, Hospital of University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4264296 Wed, 15 Dec 2010 20:47:52 +0100 4264296 Monitoring the Effect of Targeted Therapies in a Gastrointestinal Stromal Tumor Xenograft Using a Clinical PET/CT http://www.medworm.com/index.php?rid=4264298&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F620005p788230516%2F Conclusions  Significant anti-tumor effects were demonstrated following treatment with both Imatinib and Sunitinib. Decreased tumor-to-liver uptake ratios were more pronounced than tumor volume reductions. Effects of novel targeted therapies can be evaluated in the GIST xenograft model using a clinical PET/CT scanner. Content Type Journal ArticleDOI 10.1007/s11307-010-0464-0Authors Mona-Elisabeth Revheim, Department of Nuclear Medicine, Oslo University Hospital, Rikshospitalet, Postboks 4950 Nydalen, 0424 Oslo, NorwayKathrine Røe, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, NorwayØyvind Sverre Bruland, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayTore Bach-Gansmo, Department of Nuclear Medicine, O... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4264298 Wed, 15 Dec 2010 20:47:51 +0100 4264298 Impact of Cell-Proliferation-Associated Gene Expression on 2-Deoxy-2-[18F]fluoro-d-Glucose (FDG) Kinetics as Measured by Dynamic Positron Emission Tomography (dPET) in Colorectal Tumors http://www.medworm.com/index.php?rid=4252571&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb65263q614047713%2F Conclusions  The results suggest that the FDG kinetics is modulated by proliferation associated genes. Especially K1, the parameter for the FDG transport into the cells, is modulated by cdk2. Tumors with a SUV exceeding 12 have usually a higher expression of cyclin D2. The parameters of the FDG kinetics can be used to predict the expression of proliferation associated genes individually. Content Type Journal ArticleDOI 10.1007/s11307-010-0465-zAuthors Ludwig G. Strauss, Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, GermanyDirk Koczan, Institute of Immunology, University Rostock, Rostock, GermanySven Klippel, Surgical Clinic A, Klinikum Ludwigshafen, Ludwigshafen, GermanyLeyun Pan, Clinical Cooper... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4252571 Fri, 10 Dec 2010 06:50:45 +0100 4252571 The Relationship between Patients’ Serum Glucose Levels and Metabolically Active Brown Adipose Tissue Detected by PET/CT http://www.medworm.com/index.php?rid=4248503&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F571l124t14261q31%2F Conclusions  Although causal relationships are not specified, the data suggest that BAT uptake, glucose levels, BMI, sex, and age are inter-related and the possibility that presence of “detectable” BAT is protective against diabetes and obesity. FDG PET/CT may be a vital tool for further investigations of diabetes and obesity. Content Type Journal ArticlePages 1-6DOI 10.1007/s11307-010-0379-9Authors Heather A. Jacene, Russell H. Morgan Department of Radiology and Radiological Science, Division of Nuclear Medicine, Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 3223, Baltimore, MD 21287, USAChristian C. Cohade, Russell H. Morgan Department of Radiology and Radiological Science, Division of Nuclear Medicine, Johns Hopkins University Sc... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4248503 Wed, 08 Dec 2010 07:04:54 +0100 4248503 A Pre-targeting Strategy for MR Imaging of Functional Molecules Using Dendritic Gd-Based Contrast Agents http://www.medworm.com/index.php?rid=4244639&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx415485703g73m16%2F Conclusions  This pre-targeting approach can accomplish sensitive and specific in vivo MRI of functional molecules. Content Type Journal ArticlePages 1-8DOI 10.1007/s11307-010-0463-1Authors Kohei Sano, Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501 JapanTakashi Temma, Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501 JapanTakashi Azuma, Department of Medical Simulation Engineering Research Center for Nano Medical Engineering Institute for Frontier Medical Sciences, Kyoto University, Kyoto, 606-8501 JapanRyusuke Nakai, Department of Medical Simu... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4244639 Tue, 07 Dec 2010 16:45:10 +0100 4244639 Current Evidence Base of FDG-PET/CT Imaging in the Clinical Management of Malignant Pleural Mesothelioma: Emerging Significance of Image Segmentation and Global Disease Assessment http://www.medworm.com/index.php?rid=4244640&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn0065q271u445020%2F Abstract  Increasingly, integrated positron emission tomography-computed tomography (PET/CT) imaging is playing a crucial role in the assessment of patients with known or suspected malignant pleural mesothelioma (MPM). Based on the data reported in the literature, this combined modality is likely to become the instrument of choice for examining patients of MPM. The research on this subject has focused on the following five domains: (1) differentiation of MPM from other benign pleural diseases, (2) preoperative staging for the selection of appropriate candidates for surgery, (3) evaluation for therapy response and post-treatment surveillance for recurrence, (4) prognostication based upon the intensity of 2-deoxy-2-[18F]fluoro-d-glucose (FDG) uptake, and (5) planning of radiot... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4244640 Tue, 07 Dec 2010 06:55:44 +0100 4244640 Evaluation of the Olfactory Nerve Transport Function by SPECT-MRI Fusion Image with Nasal Thallium-201 Administration http://www.medworm.com/index.php?rid=4241160&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu048249084g71738%2F Conclusions  Nasal 201Tl administration was safely used to assess the direct pathway to the brain via the nose in healthy volunteers with normal olfactory threshold. Content Type Journal ArticleDOI 10.1007/s11307-010-0461-3Authors Hideaki Shiga, Department of Otorhinolaryngology—Head and Neck Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinadamachi, Kahokugun, Ishikawa, 920-0293 JapanJunichi Taki, Department of Biotracer Medicine, Graduate School of Medical Science, Kanazawa University, Ishikawa, 920-8640 JapanMasato Yamada, Division of Radioisotopes, Kanazawa University Hospital, Ishikawa, 920-8640 JapanKohshin Washiyama, Department of Quantum Medical Technology, Graduate School of Medical Science, Kanazawa University, Ishikawa, 920-0942 JapanRyohei Amano, ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4241160 Mon, 06 Dec 2010 18:49:05 +0100 4241160 Longitudinal Molecular Imaging with Single Cell Resolution of Disseminated Ovarian Cancer in Mice with a LED-based Confocal Microendoscope http://www.medworm.com/index.php?rid=4241159&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl671643k177873mq%2F Conclusions  These studies establish microendoscope technology with single cell resolution for minimally-invasive, longitudinal imaging in living animals. This technology will advance future molecular imaging studies of ovarian cancer and other diseases. Content Type Journal ArticleDOI 10.1007/s11307-010-0455-1Authors Sakib F. Elahi, Department of Biomedical Engineering, University of Michigan, 109 Zina Pitcher Place, BSRB 1728, Ann Arbor, MI 48109, USAZhongyao Liu, Department of Medicine, Division of Gastroenterology, University of Michigan, 109 Zina Pitcher Place, BSRB 1728, Ann Arbor, MI 48109, USAKathryn E. Luker, Center for Molecular Imaging, Department of Radiology, University of Michigan, 109 Zina Pitcher Place, BSRB A526, Ann Arbor, MI 48109, USARichard S. Kwo... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4241159 Mon, 06 Dec 2010 18:49:05 +0100 4241159 Practice Based Evidence of the Beneficial Impact of PET in Patients with Brain Tumors http://www.medworm.com/index.php?rid=4186577&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fag75v25j2g47r27q%2F Content Type Journal ArticleDOI 10.1007/s11307-010-0446-2Authors Homer A. Macapinlac, The University of Texas, M. D. Anderson Cancer Center, Houston, TX USAJohannes Czernin, University of California, Los Angeles, CA USASteven M. Larson, Memorial Sloan Kettering Cancer Center, New York, NY USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4186577 Wed, 17 Nov 2010 07:04:00 +0100 4186577 Impact of Dedicated Brain PET on Intended Patient Management in Participants of the National Oncologic PET Registry http://www.medworm.com/index.php?rid=4178615&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe4xj1hvq1j11x280%2F Conclusions  Among NOPR patients, dedicated brain PET was associated with similar net changes in intended management as in the overall NOPR cohort. However, brain PET patients were younger, more likely to be symptomatic, and less likely to have a change in management from non-treatment to treatment as a post-PET plan. Content Type Journal ArticleDOI 10.1007/s11307-010-0427-5Authors Bruce E. Hillner, Department of Internal Medicine, Virginia Commonwealth University, 1101 E. Marshall St. Room 7013, Richmond, VA 23298-0170, USABarry A. Siegel, Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO USAAnthony F. Shields, Karmanos Cancer Institute, Wayne State University, Detroit, MI USAFenghai Duan, Cent... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4178615 Tue, 16 Nov 2010 07:00:25 +0100 4178615 Trafficking of a Dual-Modality Magnetic Resonance and Fluorescence Imaging Superparamagnetic Iron Oxide-Based Nanoprobe to Lymph Nodes http://www.medworm.com/index.php?rid=4178617&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm3830245x14q4754%2F Conclusions  After injection, SCION passively migrates to LNs without macrophage uptake and then can be used to image LN(s) by MRI and fluorescence. Thus, SCION can potentially be developed for use in sentinel node resections or for intralymphatic drug delivery. Content Type Journal ArticleDOI 10.1007/s11307-010-0424-8Authors Ambika Bumb, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USACeleste A. S. Regino, Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USAJackson G. Egen, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USAMarcelino Bernardo, Molecular Imaging Program, ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4178617 Tue, 16 Nov 2010 07:00:23 +0100 4178617 Impact of Indium-111 Oxine Labelling on Viability of Human Mesenchymal Stem Cells In Vitro, and 3D Cell-Tracking Using SPECT/CT In Vivo http://www.medworm.com/index.php?rid=4178616&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw755tv10w35133k4%2F Conclusions   111In-oxine labelling moderately impaired hMSC’s functional integrity while preserving their stem cell character. Combined SPECT/CT imaging of 111In-oxine-labelled hMSC opens the possibility for non-invasive sequential monitoring of therapeutic stem cells. Content Type Journal ArticleDOI 10.1007/s11307-010-0439-1Authors Franz Josef Gildehaus, Department of Nuclear Medicine, University of Munich (LMU), Marchioninistraße 15, 81377 Munich, GermanyFlorian Haasters, Experimental Surgery and Regenerative Medicine, Department of Surgery, University of Munich (LMU), Nussbaumstr. 20, 80336, Munich, GermanyInga Drosse, Experimental Surgery and Regenerative Medicine, Department of Surgery, University of Munich (LMU), Nussbaumstr. 20, 80336, Munich, GermanyErika... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4178616 Tue, 16 Nov 2010 07:00:23 +0100 4178616 Proceedings of the 2010 World Molecular Imaging Congress, Kyoto, Japan, September 8-11, 2010 http://www.medworm.com/index.php?rid=4164169&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw7k13646l7w1g527%2F Content Type Journal ArticleDOI 10.1007/s11307-010-0453-3 Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4164169 Thu, 11 Nov 2010 06:57:52 +0100 4164169 Extraction of Input Function from Rat [18F]FDG PET Images http://www.medworm.com/index.php?rid=4158389&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb4164367gln80t70%2F Conclusion  It is possible to estimate the input function from rat [18F]FDG PET images, thus facilitating the assessment of glucose metabolism without affecting the physiological conditions of the animal as a result of abundant blood sampling. Content Type Journal ArticleDOI 10.1007/s11307-010-0449-zAuthors Nobuyuki Kudomi, Turku PET Centre, University of Turku, Turku, FinlandMarco Bucci, Turku PET Centre, University of Turku, Turku, FinlandVesa Oikonen, Turku PET Centre, University of Turku, Turku, FinlandMika Silvennoinen, Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, FinlandHeikki Kainulainen, Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, FinlandPirjo Nuutila, Turku PET Centre, University o... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4158389 Tue, 09 Nov 2010 07:51:50 +0100 4158389 Erratum to: Intraoperative Multispectral Fluorescence Imaging for the Detection of the Sentinel Lymph Node in Cervical Cancer: A Novel Concept http://www.medworm.com/index.php?rid=4149791&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw81h1q4x453m0jg7%2F Content Type Journal ArticleDOI 10.1007/s11307-010-0443-5Authors Lucia M. A. Crane, Department of Surgery, University Medical Center Groningen, Groningen, the NetherlandsGeorge Themelis, Technical University Munich and Helmholtz Zentrum Munich, Institute for Biological and Medical Imaging (IBMI), Munich, GermanyRick G. Pleijhuis, Department of Surgery, University Medical Center Groningen, Groningen, the NetherlandsNiels J. Harlaar, Department of Surgery, University Medical Center Groningen, Groningen, the NetherlandsAthanasios Sarantopoulos, Technical University Munich and Helmholtz Zentrum Munich, Institute for Biological and Medical Imaging (IBMI), Munich, GermanyHenriette J. G. Arts, Department of Obstetrics and Gynaecology, University Medical Center Groningen, Groningen, the Nether... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4149791 Sat, 06 Nov 2010 20:10:40 +0100 4149791 In Vivo Bioluminescence Imaging of Inducible Nitric Oxide Synthase Gene Expression in Vascular Inflammation http://www.medworm.com/index.php?rid=4149792&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5705h6704170h166%2F Conclusions  BLI allows in vivo detection of iNOS expression in murine carotid lesions and may provide a valuable approach for monitoring vascular gene expression and inflammation in small animal models. Content Type Journal ArticleDOI 10.1007/s11307-010-0451-5Authors Masahiro Terashima, Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Room H2157, Stanford, CA 94305-5233, USAShoichi Ehara, Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Room H2157, Stanford, CA 94305-5233, USAEugene Yang, Division of Cardiology, University of Washington School of Medicine, Seattle, WA USAHisanori Kosuge, Division of Cardiovascular Medicine, Stanford University School of Medicine, 300 Pasteur... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4149792 Sat, 06 Nov 2010 20:10:39 +0100 4149792 Introduction to the Proceedings of the 3rd World Molecular Imaging Congress http://www.medworm.com/index.php?rid=4142465&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1w4478t850q262x5%2F Content Type Journal ArticleDOI 10.1007/s11307-010-0454-2 Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4142465 Fri, 05 Nov 2010 11:04:44 +0100 4142465 Table of Contents: Proceedings of the 2010 World Molecular Imaging Congress http://www.medworm.com/index.php?rid=4132485&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkn0721618544152m%2F Content Type Journal ArticleDOI 10.1007/s11307-010-0452-4 Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4132485 Mon, 01 Nov 2010 17:59:08 +0100 4132485 Comparison of 11C-Methionine PET and 18F-FDG PET in Patients with Primary Central Nervous System Lymphoma http://www.medworm.com/index.php?rid=4132484&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4644657w05h65q21%2F Conclusion  There was no significant difference between T/N ratios using MET PET and FDG PET, although uptake of MET in CNS lymphoma was significantly lower than that of FDG. MET PET showed as high a sensitivity as FDG PET for the detection of primary lesions in patients with CNS lymphoma. Content Type Journal ArticleDOI 10.1007/s11307-010-0447-1Authors Yoshiro Kawase, Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793 JapanYuka Yamamoto, Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793 JapanReiko Kameyama, Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793 JapanNobuy... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4132484 Mon, 01 Nov 2010 17:59:08 +0100 4132484 In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model http://www.medworm.com/index.php?rid=4132486&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb01415j0355h8715%2F Conclusion  The scVEGF/Cy probe delivered via colonic lavage reaches tumor vasculature and selectively accumulates in VEGFR-2-positive areas, resulting in high sensitivity and specificity for tumor detection. The combination of OCT and LIF imaging modalities may allow the simultaneous study of tumor morphology and protein expression for the development of diagnostic and therapeutic methods for colorectal cancer. Content Type Journal ArticleDOI 10.1007/s11307-010-0450-6Authors Amy M. Winkler, College of Optical Sciences, The University of Arizona, 1657 East Helen Street, Tucson, AZ 85721, USAPhotini F. S. Rice, Department of Biomedical Engineering, The University of Arizona, 1657 East Helen Street, Tucson, AZ 85721, USAJan Weichsel, Molecular and Cellular Biology, Th... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4132486 Mon, 01 Nov 2010 17:59:07 +0100 4132486 Pilot Evaluation of Anti-1-amino-2-[18F] fluorocyclopentane-1-carboxylic acid (anti-2-[18F] FACPC) PET-CT in Recurrent Prostate Carcinoma http://www.medworm.com/index.php?rid=4117040&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fup54vn61q514ul48%2F Conclusions  While prostate bed lesions are visible on early imaging with anti-2-[18F]FACPC, there is high blood pool activity obscuring nodes. As blood pool fades, nodal uptake decreases and high bladder activity then obscures pelvic structures. Compared with anti-[18F]FACBC, imaging characteristics for anti-2-[18F]FACPC are unfavorable for pelvic recurrent prostate carcinoma detection. Content Type Journal ArticleDOI 10.1007/s11307-010-0445-3Authors Bital Savir-Baruch, Radiology, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USADavid M. Schuster, Radiology, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USANashwa Jarkas, Radiology, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USAViraj A. Master, Urology, Emory University, Atlanta, GA US... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4117040 Tue, 26 Oct 2010 06:52:13 +0100 4117040 Synthesis and Preliminary Evaluation of Piperidinyl and Pyrrolidinyl Iodobenzoates as Imaging Agents for Butyrylcholinesterase http://www.medworm.com/index.php?rid=4117041&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk1p41763260q3047%2F Conclusion  BuChE-specific radiolabeled iodobenzoates enter the brain and, in general, label areas known to exhibit BuChE activity in histochemical studies. Such molecules may represent a new direction for the development of agents for the molecular imaging of BuChE in the living brain, especially in regions where BuChE-containing neuropathological structures appear in AD. Content Type Journal ArticleDOI 10.1007/s11307-010-0448-0Authors Ian R. Macdonald, Department of Anatomy and Neurobiology and the Neuroscience Institute, Dalhousie University, Halifax, NS B3H 1X5, CanadaG. Andrew Reid, Department of Anatomy and Neurobiology and the Neuroscience Institute, Dalhousie University, Halifax, NS B3H 1X5, CanadaE. Eric Joy, Department of Chemistry and Physics, Mount Saint ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4117041 Tue, 26 Oct 2010 06:52:12 +0100 4117041 Molecular Imaging of Vasa Vasorum Neovascularization via DEspR-targeted Contrast-enhanced Ultrasound Micro-imaging in Transgenic Atherosclerosis Rat Model http://www.medworm.com/index.php?rid=4104796&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv08772p1g6861012%2F Conclusion   In vivo DEspR-targeted molecular imaging detected increased DEspR-expression in carotid artery lesions and in expanded vasa vasorum neovessels in transgenic rats with carotid artery disease. Future studies are needed to determine predictive value for stroke or heart disease in this transgenic atherosclerosis rat model and translational applications. Content Type Journal ArticleDOI 10.1007/s11307-010-0444-4Authors Julius L. Decano, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, MA USAAnne Marie Moran, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, MA USANelson Ruiz-Opazo, Whitaker Cardiovascular Institute, Department of Medicine, Boston Uni... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4104796 Sat, 23 Oct 2010 05:45:53 +0100 4104796 Temporal Variations of Skin Pigmentation in C57Bl/6 Mice Affect Optical Bioluminescence Quantitation http://www.medworm.com/index.php?rid=4095989&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn8l7632344x234mr%2F Conclusion  Skin pigmentation is a significant variable in bioluminescent imaging, and should be considered in experimental design and implementation for longitudinal studies, and especially when sensitivity to small signal changes, or differences among animals, is required. Content Type Journal ArticleDOI 10.1007/s11307-010-0440-8Authors Allison Curtis, Global Imaging Group, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, USAKatherine Calabro, Department of Biomedical Engineering, Boston University, Boston, MA USAJean-Rene Galarneau, Translational Sciences, Novartis Institutes for BioMedical Research, Inc., Cambridge, MA USAIrving J. Bigio, Department of Biomedical Engineering, Boston University, Boston, MA USAThomas Kruck... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4095989 Wed, 20 Oct 2010 12:10:11 +0100 4095989 A Portable Fluorescence Camera for Testing Surgical Specimens in the Operating Room: Description and Early Evaluation http://www.medworm.com/index.php?rid=4095991&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm768622r32366j7j%2F Conclusion  We demonstrate the feasibility of a specimen-based portable fluorescence camera for use in the operating room. Its small size ensures that tissue excised from patients can be tested promptly for fluorescence within the operating room environment, thus expediting the testing of novel imaging probes. Content Type Journal ArticleDOI 10.1007/s11307-010-0438-2Authors John W. Kakareka, Signal Processing and Instrumentation Section, Division of Computational Bioscience, Center of Information Technology, National Institutes of Health, 12 South Dr., Bethesda, MD 20892-5624, USAThomas E. McCann, Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room B3B69, MSC1088, 10 Center Dr., Bethesda, ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4095991 Wed, 20 Oct 2010 12:10:10 +0100 4095991 Where It’s at Really Matters: In Situ In Vivo Vascular Endothelial Growth Factor Spatially Correlates with Electron Paramagnetic Resonance pO2 Images in Tumors of Living Mice http://www.medworm.com/index.php?rid=4095990&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw1hgg6001135820t%2F Conclusions  This validates EPROI hypoxic fractions at the molecular level and provides a new paradigm for the assessment of the relationship, in vivo, between hypoxia and hypoxia response proteins. When translated to human subjects, this will enhance understanding of human tumor pathophysiology and cancer response to therapy. Content Type Journal ArticleDOI 10.1007/s11307-010-0436-4Authors Martyna Elas, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL USADanielle Hleihel, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL USAEugene D. Barth, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL USAChad R. Haney, Department of Radiology, University of Chicago, Chicago, IL USAK... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4095990 Wed, 20 Oct 2010 12:10:10 +0100 4095990 Monitoring the Longitudinal Intra-tumor Physiological Impulse Response to VEGFR2 Blockade in Breast Tumors Using DCE-CT http://www.medworm.com/index.php?rid=4095992&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm6k2385563526422%2F Conclusion  Inhibiting VEGFR2 activity results in a temporal decoupling of physiological parameters, which can be explained by a combination of morphological changes influencing perfusion. Such a decoupling has the potential to significantly impact the delivery of pharmaceuticals and oxygen within solid tumors, critical factors in combined anti-angiogenic and radio- and chemotherapies. Content Type Journal ArticleDOI 10.1007/s11307-010-0441-7Authors Keith M. Stantz, School of Health Sciences; Division of Medical Physics, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47907-2051, USAMinsong Cao, School of Health Sciences; Division of Medical Physics, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47907-2051, USANing Cao, School of Health ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4095992 Tue, 19 Oct 2010 23:47:15 +0100 4095992 Relationship Between Striatal Dopamine Transporter Availability and Sleep Quality in Healthy Adults http://www.medworm.com/index.php?rid=4095993&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk4145u4w382254w9%2F Conclusions  The study demonstrates that healthy poor sleepers, with a lower DAT availability in the caudate, sleep for a shorter length of time. This suggests that a decrease in DA reuptake due to reduced DAT availability causes a shorter sleep duration in poor sleepers. Content Type Journal ArticleDOI 10.1007/s11307-010-0442-6Authors Nan-Tsing Chiu, Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 704 TaiwanBi-Fang Lee, Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 704 TaiwanTzung Lieh Yeh, Department of Psychiatry, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan, 704 TaiwanPo See Chen, Department of Psychia... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4095993 Sat, 16 Oct 2010 08:03:35 +0100 4095993 On the Use of Micron-Sized Iron Oxide Particles (MPIOS) to Label Resting Monocytes in Bone Marrow http://www.medworm.com/index.php?rid=4064593&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq0313t85hg813152%2F Conclusions  Systemic administration of various MPIO formulations showed that MPIOs arrive in bone marrow rapidly following injection and remain there for at least 7 days. Data also shows slow clearance of some particles from the tissue over this period. While MPIOs can efficiently label monocytes in culture and in whole blood ex vivo, they were not found to label bone marrow resident monocytes. Content Type Journal ArticleDOI 10.1007/s11307-010-0437-3Authors Kevin S. Tang, Department of Biomedical Engineering, Yale University School of Medicine, New Haven, CT USABradley Hann, Department of Biomedical Engineering, Yale University School of Medicine, New Haven, CT USAErik M. Shapiro, Department of Diagnostic Radiology, Yale University School of Medicine, 300 Ceda... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4064593 Sat, 09 Oct 2010 05:58:32 +0100 4064593 Comparison of Different SUV-Based Methods for Response Prediction to Neoadjuvant Radiochemotherapy in Locally Advanced Rectal Cancer by FDG-PET and MRI http://www.medworm.com/index.php?rid=4064594&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp3950j0nv6383757%2F Conclusions  Our study emphasizes that 3D-based approaches for assessing SUV values consistently belonged to the group of parameters with the highest AUC values for prediction of HPR to neoadjuvant RCTx in patients with rectal cancer. MRI was not a good predictor for therapy response; hence, the MRI information derived from combined anatomic and metabolic parameters showed unsatisfying results too. Content Type Journal ArticleDOI 10.1007/s11307-010-0383-0Authors Ken Herrmann, Department of Nuclear Medicine, Klinikum rechts der Isar der Technischen Universität München, Munich, GermanyRalph A. Bundschuh, Department of Nuclear Medicine, Klinikum rechts der Isar der Technischen Universität München, Munich, GermanyRobert Rosenberg, Department of Surgery, Klinikum rec... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4064594 Sat, 09 Oct 2010 05:58:30 +0100 4064594 Towards PET Imaging of Intact Pancreatic Beta Cell Mass: A Transgenic Strategy http://www.medworm.com/index.php?rid=4044350&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj229x00n32211565%2F Conclusions  The MIP-sr39tk mouse demonstrates that PET imaging can detect changes in beta cell mass that precede the onset of diabetes. Content Type Journal ArticleDOI 10.1007/s11307-010-0435-5Authors Rebecca McGirr, Lawson Health Research Institute, Diabetes and Metabolism, 268 Grosvenor St, London, ON N6A 4V2, CanadaShirley Hu, Department of Medical Biophysics, The University of Western Ontario, London, ON CanadaSiu-Pok Yee, Victoria Research Laboratories, London Regional Cancer Program, London, ON CanadaMichael S. Kovacs, Lawson Health Research Institute, Imaging Programs, 268 Grosvenor St, London, ON N6A 4V2, CanadaTing-Yim Lee, Lawson Health Research Institute, Imaging Programs, 268 Grosvenor St, London, ON N6A 4V2, CanadaSavita Dhanvantari, Lawson Health Research ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4044350 Wed, 06 Oct 2010 06:04:26 +0100 4044350 In Vivo Monitoring of Stem Cells in Drosophila Pupae Using the Radiative Transfer Equation-Based Fluorescence Molecular Tomography http://www.medworm.com/index.php?rid=4044351&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjr403150up187861%2F Conclusion  DsRed-bearing stem cells in Drosophila pupae can be markedly imaged using our FMT approach. This study suggests that the technique described can be used for dynamic in vivo monitoring of biological events in mesoscopic-scale animals and facilitates basic biologic research such as genetics, epigenetics, and stem cells. Content Type Journal ArticleDOI 10.1007/s11307-010-0434-6Authors Yiyong Tan, J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USAMichael Novo, Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USALei Yao, J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USALei Zhou, Department ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4044351 Tue, 05 Oct 2010 05:49:25 +0100 4044351 In Situ Labeling and Magnetic Resonance Imaging of Transplanted Human Hepatic Stem Cells http://www.medworm.com/index.php?rid=4035760&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkh27962u0277732m%2F Conclusions  This magnetic labeling methodology can be used with any antibody coupled to a magnetic particle to target any surface antigen that distinguishes transplanted cells from host cells, thus facilitating studies that define methods and strategies for clinical cell therapy programs. Content Type Journal ArticleDOI 10.1007/s11307-010-0422-xAuthors Randall McClelland, Department of Cell and Molecular Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USAEliane Wauthier, Department of Cell and Molecular Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USATommi Tallheden, Department of Cell and Molecular Physiology, UNC School of Medicine, Chapel Hill, NC 27599, USALola M. Reid, Department of Cell and Molecular Physiology, UNC School of Medicine,... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4035760 Sat, 02 Oct 2010 05:55:59 +0100 4035760 Quantitative Assessment of Diffusion-Weighted MR Imaging in Patients with Primary Rectal Cancer: Correlation with FDG-PET/CT http://www.medworm.com/index.php?rid=4011536&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn8ll1181715642t2%2F Conclusion  The significant negative correlations between ADC and SUV suggest an association between tumor cellularity and metabolic activity in primary rectal adenocarcinoma. Content Type Journal ArticleDOI 10.1007/s11307-010-0433-7Authors Jing Gu, Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, ChinaPek-Lan Khong, Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, ChinaSilun Wang, Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, ChinaQueenie Chan, Philips Healthcare, Philips Electronics Hong Kong Limited, Hong Kong, ChinaWailun LAW, Division of Colorectal Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, ChinaJingbo Zhang, Department of Diagnostic Radiology, The Unive... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4011536 Sat, 25 Sep 2010 05:59:16 +0100 4011536 Correlation Between Epidermal Growth Factor Receptor-Specific Nanobody Uptake and Tumor Burden: A Tool for Noninvasive Monitoring of Tumor Response to Therapy http://www.medworm.com/index.php?rid=4002661&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7554153256355343%2F Conclusion   99mTc-7C12 binds to EGFR with high affinity and specificity. Tumor uptake is correlated with tumor burden. Quantification of 99mTc-7C12 uptake is promising for monitoring therapy response of EGFR-expressing tumors. Content Type Journal ArticleDOI 10.1007/s11307-010-0428-4Authors Lea Olive Tchouate Gainkam, ICMI, In vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, BelgiumMarleen Keyaerts, ICMI, In vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, BelgiumVicky Caveliers, ICMI, In vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, 1090 Brussels, BelgiumNick Devoogdt, ICMI, In vivo... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4002661 Fri, 24 Sep 2010 05:48:33 +0100 4002661 Preclinical Lymphatic Imaging http://www.medworm.com/index.php?rid=4001316&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqt83632873wj1gt6%2F Abstract  Noninvasive in vivo imaging of lymphatic vessels and lymphatic nodes is expected to fulfill the purpose of analyzing lymphatic vessels and their function, understanding molecular mechanisms of lymphangiogenesis and lymphatic spread of tumors, and utilizing lymphatic molecular markers as a prognostic or diagnostic indicator. In this review, we provide a comprehensive summary of in vivo imaging modalities for detecting lymphatic vessels, lymphatic drainage, and lymphatic nodes, which include conventional lymphatic imaging techniques such as dyes and radionuclide scintigraphy as well as novel techniques for lymphatic imaging such as optical imaging, computed tomography, magnetic resonance imaging, ultrasound, positron emission tomography using lymphatic biomarkers, ph... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4001316 Thu, 23 Sep 2010 05:49:58 +0100 4001316 A New Nano-sized Iron Oxide Particle with High Sensitivity for Cellular Magnetic Resonance Imaging http://www.medworm.com/index.php?rid=4001317&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8677w180p44532r7%2F Conclusion  ITRI-IOP, the nano-sized iron oxide particle, shows high efficiency in cell labeling, including both phagocytic and non-phagocytic cells. Furthermore, it provides excellent sensitivity in T2*-weighted MRI, and thus can serve as a promising contrast agent for in vivo cellular MRI. Content Type Journal ArticleDOI 10.1007/s11307-010-0430-xAuthors Chih-Lung Chen, Biomedical Engineering Laboratories, Industrial Technology Research Institute, Hsinchu, TaiwanHaosen Zhang, Pittsburgh NMR Center for Biomedical Research and Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Ave, Pittsburgh, PA 15213, USAQing Ye, Pittsburgh NMR Center for Biomedical Research and Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Ave, Pitt... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=4001317 Thu, 23 Sep 2010 05:49:57 +0100 4001317 Radiosynthesis and Initial In Vitro Evaluation of [18F]F-PEG6-IPQA—A Novel PET Radiotracer for Imaging EGFR Expression-Activity in Lung Carcinomas http://www.medworm.com/index.php?rid=3997978&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe5257n114435k757%2F Conclusion  We have synthesized [18F]F-PEG6-IPQA and demonstrated its highly selective accumulation in active mutant L858R EGFR-expressing NSCLC cells in vitro. Further in vivo studies are warranted to assess the ability of PET imaging with [18F]F-PEG6-IPQA to discriminate the active mutant L858R EGFR-expressing NSCLC that are sensitive to therapy with EGFR kinase inhibitors vs NSCLC that express wild-type EGFR. Content Type Journal ArticleDOI 10.1007/s11307-010-0408-8Authors Ashutosh Pal, Department of Experimental Diagnostic Imaging, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USAJulius A. Balatoni, Department of Experimental Diagnostic Imaging, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 7... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3997978 Wed, 22 Sep 2010 05:52:51 +0100 3997978 Determinants of Physiologic 18F-FDG Uptake in Brown Adipose Tissue in Sequential PET/CT Examinations http://www.medworm.com/index.php?rid=3992632&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe2837r2548hwu551%2F Conclusions  Age, body mass index, and outdoor temperature are significant determinants of BAT evidence at 18F-FDG PET/CT. Moreover, extension of BAT and outdoor temperature are the strongest determinants of persistence of BAT evidence on 18F-FDG PET/CT in repeated scan. Content Type Journal ArticleDOI 10.1007/s11307-010-0431-9Authors Leonardo Pace, Dipartimento di Scienze Biomorfologiche e Funzionali, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, Edificio 10, via Pansini 5, 80131 Napoli, ItalyEmanuele Nicolai, Fondazione SDN-IRCCS, Naples, ItalyDomenico D’Amico, Fondazione SDN-IRCCS, Naples, ItalyFrancesco Ibello, Fondazione SDN-IRCCS, Naples, ItalyAnna Maria Della Morte, Fondazione SDN-IRCCS, Naples, ItalyBarbara Salvatore, Fonda... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3992632 Sat, 18 Sep 2010 05:53:05 +0100 3992632 Erratum to: Chronic Cannabinoid Administration to Periadolescent Rats Modulates the Metabolic Response to Acute Cocaine in the Adult Brain http://www.medworm.com/index.php?rid=3981877&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0356618013732075%2F Content Type Journal ArticleDOI 10.1007/s11307-010-0429-3Authors Alejandro Higuera-Matas, Psychobiology Department, School of Psychology, UNED, C/Juan del Rosal n°10, 28040 Madrid, SpainMaria Luisa Soto-Montenegro, Unidad de Medicina y Cirugía Experimental, Hospital General Universitario Gregorio Marañón, Madrid, SpainGonzalo L. Montoya, Psychobiology Department, School of Psychology, UNED, C/Juan del Rosal n°10, 28040 Madrid, SpainVerónica García-Vázquez, CIBERSAM, Madrid, SpainJavier Pascau, Unidad de Medicina y Cirugía Experimental, Hospital General Universitario Gregorio Marañón, Madrid, SpainMiguel Miguéns, Psychobiology Department, School of Psychology, UNED, C/Juan del Rosal n°10, 28040 Madrid, SpainNuria Del Olmo, Department of Pharmaceutical and Food Sciences, Sch... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3981877 Fri, 17 Sep 2010 06:51:01 +0100 3981877 Preclinical Imaging of Therapy Response Using Metabolic and Apoptosis Molecular Imaging http://www.medworm.com/index.php?rid=3981878&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F72m6611j64110652%2F Conclusion  In this preclinical model, 99mTc-hAnxA5 imaging was able to detect apoptosis before metabolic changes were measured. These results confirm the value of apoptosis imaging for therapy response and give more insight in [18F]FDG imaging and its parameters to evaluate response. Content Type Journal ArticleDOI 10.1007/s11307-010-0412-zAuthors Marijke De Saint-Hubert, Department of Nuclear Medicine, University Hospital Gasthuisberg Leuven, Herestraat 49, 3000 Leuven, BelgiumHuijun Wang, Department of Radiology, University Hospital Gasthuisberg Leuven, Herestraat 49, 3000 Leuven, BelgiumEllen Devos, Department of Nuclear Medicine, University Hospital Gasthuisberg Leuven, Herestraat 49, 3000 Leuven, BelgiumKathleen Vunckx, Department of Nuclear Medicine, University... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3981878 Fri, 17 Sep 2010 06:50:59 +0100 3981878 A Noninvasive [99mTc]DTPA SPECT/CT Imaging Methodology as a Measure of Lung Permeability in a Guinea Pig Model of COPD http://www.medworm.com/index.php?rid=3981879&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbl77816643m38m53%2F Conclusions  The combined SPECT/CT imaging method developed here can be used for serial evaluation of lung function and its response to drug therapy in guinea pig model of COPD. Content Type Journal ArticleDOI 10.1007/s11307-010-0423-9Authors Yanjun Wu, Molecular Imaging Center of Excellence, R&D, GlaxoSmithKline, King of Prussia, PA 19406, USACharles J. Kotzer, Respiratory CEDD, R&D, GlaxoSmithKline, King of Prussia, PA 19406, USASokratis Makrogiannis, Molecular Imaging Center of Excellence, R&D, GlaxoSmithKline, King of Prussia, PA 19406, USAGregory A. Logan, Respiratory CEDD, R&D, GlaxoSmithKline, King of Prussia, PA 19406, USAHyking Haley, Laboratory Animal Science, R&D, GlaxoSmithKline, King of Prussia, PA 19406, USAMary S. Barnette, Respiratory CEDD, R&D, GlaxoS... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3981879 Tue, 14 Sep 2010 06:03:19 +0100 3981879 18F-FET PET/CT in Advanced Head and Neck Squamous Cell Carcinoma: an Intra-individual Comparison with 18F-FDG PET/CT http://www.medworm.com/index.php?rid=3981880&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft57572l022310047%2F Conclusions   18F-FET is no substitute for 18F-FDG. Although it is more specific, too many malignant lesions are missed due to its lower sensitivity. Content Type Journal ArticleDOI 10.1007/s11307-010-0419-5Authors Stephan Kurt Haerle, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Frauenklinikstrasse 24, CH-8091 Zurich, SwitzerlandDorothee R. Fischer, Department of Nuclear Medicine, University Hospital Zurich, Raemistrasse 100, CH-8091 Zurich, SwitzerlandDaniel T. Schmid, Department of Nuclear Medicine, University Hospital Zurich, Raemistrasse 100, CH-8091 Zurich, SwitzerlandNader Ahmad, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Frauenklinikstrasse 24, CH-8091 Zurich, SwitzerlandGerhar... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3981880 Tue, 14 Sep 2010 06:02:59 +0100 3981880 Imaging the Bio-Distribution of Fluorescent Probes Using Multispectral Epi-Illumination Cryoslicing Imaging http://www.medworm.com/index.php?rid=3981882&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F944623n241274713%2F Conclusions  Serving both as a method for accurately imaging the bio-distribution of multiple fluorescent agents inside organisms and as a modality for the validation of non-invasive methods, multispectral cryoslicing imaging offers useful insights to ex vivo optical imaging of molecular probes. Content Type Journal ArticleDOI 10.1007/s11307-010-0416-8Authors Athanasios Sarantopoulos, Chair for Biological Imaging, Technische Universität München, Arcisstrasse 21, 80333 Munich, GermanyGeorge Themelis, Chair for Biological Imaging, Technische Universität München, Arcisstrasse 21, 80333 Munich, GermanyVasilis Ntziachristos, Chair for Biological Imaging, Technische Universität München, Arcisstrasse 21, 80333 Munich, Germany Journal Molecular Imaging and Biolog... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3981882 Tue, 14 Sep 2010 06:02:47 +0100 3981882 Synthesis of 2′-Deoxy-2′-[18F]Fluoro-9-β-D-Arabinofuranosylguanine: a Novel Agent for Imaging T-Cell Activation with PET http://www.medworm.com/index.php?rid=3981881&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F91r4n380k24885u0%2F Conclusion  For the first time to the best of our knowledge, [18F]F-AraG has been successfully synthesized by direct fluorination of an appropriate precursor of a guanosine nucleoside. This approach maybe also useful for the synthesis of other important positron emission tomography (PET) probes such as [18F]FEAU, [18F]FMAU, and [18F]FBAU which are currently synthesized by multiple steps and involve lengthy purification. The cell uptake studies support future studies to investigate the use of [18F]F-AraG as a PET imaging agent of T cells. Content Type Journal ArticleDOI 10.1007/s11307-010-0414-xAuthors Mohammad Namavari, Molecular Imaging Program at Stanford (MIPS), Stanford University, 318 Campus Dr., Clark Center, E-150, Stanford, CA 94305, USAYa-Fang Chang, Molecul... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3981881 Tue, 14 Sep 2010 06:02:47 +0100 3981881 Saposin C Coupled Lipid Nanovesicles Enable Cancer-Selective Optical and Magnetic Resonance Imaging http://www.medworm.com/index.php?rid=3981883&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9600169601883p51%2F Conclusions  SapC–DOPS nanovesicles offer promise as a new and robust theranostic agent for broad cancer-selective detection, visualization, and potential therapy. Content Type Journal ArticleDOI 10.1007/s11307-010-0417-7Authors Vinod Kaimal, Biomedical Engineering, Cincinnati Children’s Hospital Medical Center, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USAZhengtao Chu, Division and Program in Human Genetics, Cincinnati Children’s Hospital Medical Center, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USAYonatan Y. Mahller, Hematology/Oncology, Cincinnati Children’s Hospital Medical Center, College of Medicine, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 4... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3981883 Tue, 14 Sep 2010 06:02:46 +0100 3981883 PET Imaging of Hypoxia-Inducible Factor-1-Active Tumor Cells with Pretargeted Oxygen-Dependent Degradable Streptavidin and a Novel 18F-Labeled Biotin Derivative http://www.medworm.com/index.php?rid=3981885&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F987270tq46525633%2F Conclusion  Pretargeting with POS and 18F-FBB is an effective approach for PET imaging of HIF-1-active areas in tumors. Content Type Journal ArticleDOI 10.1007/s11307-010-0418-6Authors Takashi Kudo, Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501 JapanMasashi Ueda, Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501 JapanHiroaki Konishi, Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501 JapanHidekazu Kawashima, Department of Patho-Funct... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3981885 Tue, 14 Sep 2010 06:02:45 +0100 3981885 Tumor Hypoxia Imaging http://www.medworm.com/index.php?rid=3981884&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9542g7qj40872083%2F Abstract  There is a need to measure tumor hypoxia in assessing the aggressiveness of tumor and predicting the outcome of therapy. A number of invasive and noninvasive techniques have been exploited to measure tumor hypoxia, including polarographic needle electrodes, immunohistochemical staining, radionuclide imaging (positron emission tomography [PET] and single-photon emission computed tomography [SPECT]), magnetic resonance imaging (MRI), optical imaging (bioluminescence and fluorescence), and so on. This review article summarizes and discusses the pros and cons of each currently available method for measuring tissue oxygenation. Special emphasis was placed on noninvasive imaging hypoxia with emerging new agents and new imaging technologies to detect the molecular events... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3981884 Tue, 14 Sep 2010 06:02:45 +0100 3981884 Intraoperative Multispectral Fluorescence Imaging for the Detection of the Sentinel Lymph Node in Cervical Cancer: A Novel Concept http://www.medworm.com/index.php?rid=3964949&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqg8k700675666836%2F Conclusions  We conclude that lymphatic mapping and detection of the SLN in cervical cancer using intraoperative NIRF imaging is technically feasible. However, the technique needs to be refined for full applicability in cervical cancer in terms of sensitivity and specificity. Content Type Journal ArticleDOI 10.1007/s11307-010-0425-7Authors Lucia M. A. Crane, Department of Surgery, University Medical Center Groningen, Groningen, the NetherlandsGeorge Themelis, Technical University Munich and Helmholtz Zentrum Munich, Institute for Biological and Medical Imaging (IBMI), Munich, GermanyRick G. Pleijhuis, Department of Surgery, University Medical Center Groningen, Groningen, the NetherlandsNiels J. Harlaar, Department of Surgery, University Medical Center Groningen, Gron... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3964949 Fri, 10 Sep 2010 16:54:15 +0100 3964949 Assessing p-Glycoprotein (Pgp) Activity In Vivo Utilizing 68Ga–Schiff Base Complexes http://www.medworm.com/index.php?rid=3953262&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm506700nq2983u31%2F Conclusions  Two 68Ga-labeled ligands appear to be valuable for imaging non-invasively the intratumoral Pgp activity. On a long term, patients with multidrug-resistant tumors pre-therapeutically may be identified prior to treatment. Content Type Journal ArticleDOI 10.1007/s11307-010-0410-1Authors Marco Fellner, Institute of Nuclear Chemistry, University of Mainz, Fritz Strassmann-Weg 2, 55128 Mainz, GermanyWolfgang Dillenburg, Institute of Physiology and Pathophysiology, University Medicine Mainz, 55128 Mainz, GermanyHans-Georg Buchholz, Department of Nuclear Medicine, University Hospital, 55101 Mainz, GermanyNicole Bausbacher, Department of Nuclear Medicine, University Hospital, 55101 Mainz, GermanyMathias Schreckenberger, Department of Nuclear Medicine, University H... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3953262 Wed, 08 Sep 2010 12:21:21 +0100 3953262 Pancreatic Beta Cell Mass PET Imaging and Quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in Rodent Models of Diabetes http://www.medworm.com/index.php?rid=3953263&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F52937jx1q4824104%2F Conclusions  PET imaging with [18F]FP-(+)-DTBZ provides a noninvasive means to quantify insulin-positive BCM and may prove valuable as a diagnostic tool in assessing treatments to maintain or restore BCM. Content Type Journal ArticleDOI 10.1007/s11307-010-0406-xAuthors Tarun Singhal, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT USAYu-Shin Ding, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT USADavid Weinzimmer, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT USAMarc D. Normandin, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT USADavid Labaree, Department of Diagnostic Radiology, Yale University School of Medicine,... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3953263 Wed, 08 Sep 2010 12:21:19 +0100 3953263 In Memory of Senator Ted Stevens, 1923–2010, US Senator for the State of Alaska, 1968–2008 http://www.medworm.com/index.php?rid=3953264&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv2u6788304j3h006%2F Content Type Journal ArticleDOI 10.1007/s11307-010-0411-0 Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3953264 Wed, 08 Sep 2010 06:02:14 +0100 3953264 Articulated Whole-Body Atlases for Small Animal Image Analysis: Construction and Applications http://www.medworm.com/index.php?rid=3953265&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl021p77172131000%2F Conclusions  The articulated atlas proves to be a useful tool for multimodality image combination, follow-up studies, and image processing in the scope of molecular imaging. The proposed models were made publicly available. Content Type Journal ArticleDOI 10.1007/s11307-010-0386-xAuthors Artem Khmelinskii, Division of Image Processing (LKEB), Department of Radiology, Leiden University Medical Center (LUMC), Leiden, The NetherlandsMartin Baiker, Division of Image Processing (LKEB), Department of Radiology, Leiden University Medical Center (LUMC), Leiden, The NetherlandsEric L. Kaijzel, Department of Endocrinology, Leiden University Medical Center (LUMC), Leiden, The NetherlandsJosette Chen, Mouse Imaging Center (MICe), Hospital for Sick Children, Toronto Center for Phe... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3953265 Wed, 08 Sep 2010 06:02:12 +0100 3953265 Performance Evaluation of PETbox: A Low Cost Bench Top Preclinical PET Scanner http://www.medworm.com/index.php?rid=3932616&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy721l36x27213354%2F Conclusions  The presented results demonstrate the potential of this new tomograph for small animal imaging. Content Type Journal ArticleDOI 10.1007/s11307-010-0413-yAuthors Hui Zhang, Department of Medical and Molecular Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA USAQinan Bao, Department of Medical and Molecular Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA USANam T. Vu, Department of Medical and Molecular Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA USARobert W. Silverman, Department of Medical and Molecular Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3932616 Thu, 02 Sep 2010 15:13:27 +0100 3932616 Synthesis and Evaluation of 99mTc-Labelled Monoclonal Antibody 1D09C3 for Molecular Imaging of Major Histocompatibility Complex Class II Protein Expression http://www.medworm.com/index.php?rid=3932617&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff43nv12814145637%2F Conclusion  We efficiently labelled a humanized anti-HLA-DR mAb with 99mTc using a direct labelling method. Radiolabelled mAb binds to human HLA-DR antigens and therefore warrants further evaluation as a prognostic and diagnostic tool for patients with lymphoma or autoimmune diseases. Content Type Journal ArticleDOI 10.1007/s11307-010-0407-9Authors Gaurav Malviya, Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, University of Groningen, Groningen, The NetherlandsE. F. J. de Vries, Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, University of Groningen, Groningen, The NetherlandsRudi A. Dierckx, Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3932617 Thu, 02 Sep 2010 15:13:26 +0100 3932617 Development of High-Throughput Quantitative Assays for Glucose Uptake in Cancer Cell Lines http://www.medworm.com/index.php?rid=3932618&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff2q33vn0462r70t5%2F Conclusions  These studies indicate that 2-NBDG can be used to aid in the high-throughput analysis of the influence of chemotherapeutics on glucose uptake in cancer cells. Content Type Journal ArticleDOI 10.1007/s11307-010-0399-5Authors Mohamed Hassanein, Vanderbilt Integrative Cancer Biology Center, Vanderbilt University Medical Center, 2220 Pierce Avenue, 771 Preston Research Building, Nashville, TN 37232, USABrandy Weidow, Vanderbilt Integrative Cancer Biology Center, Vanderbilt University Medical Center, 2220 Pierce Avenue, 771 Preston Research Building, Nashville, TN 37232, USAElizabeth Koehler, Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USANaimish Bakane, Department of Biomedical Engineering, University of Michigan, A... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3932618 Thu, 02 Sep 2010 08:42:24 +0100 3932618 [11C]acetate PET/CT Visualizes Skeletal Muscle Exercise Participation, Impaired Function, and Recovery after Hip Arthroplasty; First Results http://www.medworm.com/index.php?rid=3932619&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F751l4856606h7821%2F Conclusion  Consistent increase in [11C]acetate uptake in healthy muscles under exercise compared with rest was observed by PET/CT. Transiently impaired muscle function 3 weeks after surgery recovered at 3 months. These first observations merit further investigation. Content Type Journal ArticleDOI 10.1007/s11307-010-0415-9Authors Franz Buchegger, Service of Nuclear Medicine, University Hospital of Geneva, Rue Gabrielle Perret-Gentil 4, CH 1211 Geneva 14, SwitzerlandOsman Ratib, Service of Nuclear Medicine, University Hospital of Geneva, Rue Gabrielle Perret-Gentil 4, CH 1211 Geneva 14, SwitzerlandJean-Pierre Willi, Service of Nuclear Medicine, University Hospital of Geneva, Rue Gabrielle Perret-Gentil 4, CH 1211 Geneva 14, SwitzerlandCharles Steiner, Servic... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3932619 Thu, 02 Sep 2010 08:42:23 +0100 3932619 A Low Molecular Weight Folate Receptor Targeted Contrast Agent for Magnetic Resonance Tumor Imaging http://www.medworm.com/index.php?rid=3932621&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6x6143m5755x2578%2F Conclusion  These data support the use of FR-targeted small molecular weight MRI contrast agents for tumor imaging in vivo. Content Type Journal ArticleDOI 10.1007/s11307-010-0400-3Authors Tammy L. Kalber, Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, W12 0NN UKNazila Kamaly, Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London, W12 0NN UKPo-Wah So, Biological Imaging Centre, Imperial College London, Hammersmith Hospital, London, W12 0NN UKJohn A. Pugh, Centre for Analytical Sciences, Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, S3 7HF UKJosephine Bunch, Centre for Analytical Sciences, Department... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3932621 Thu, 02 Sep 2010 08:42:22 +0100 3932621 Quantitating Antibody Uptake In Vivo: Conditional Dependence on Antigen Expression Levels http://www.medworm.com/index.php?rid=3932620&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn20225816h0p91x6%2F Conclusions  These results are consistent with the prediction that high affinity antibody uptake is dependent on antigen expression levels for saturating doses and delivery for subsaturating doses. It is imperative for any probe to understand whether quantitative uptake is a measure of biomarker expression or transport to the region of interest. The data provide support for a predictive theoretical model of antibody uptake, enabling it to be used as a starting point for the design of more efficacious therapies and timely quantitative imaging probes. Content Type Journal ArticleDOI 10.1007/s11307-010-0397-7Authors Greg M. Thurber, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USARalph Weissleder, Center for Sys... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3932620 Thu, 02 Sep 2010 08:42:22 +0100 3932620 In Vivo Cellular MRI of Dendritic Cell Migration Using Micrometer-Sized Iron Oxide (MPIO) Particles http://www.medworm.com/index.php?rid=3912976&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff5u24863480337l6%2F Conclusions  This paper presents the first report of the successful use of fluorescent MPIO particles to label and track DC migration. Content Type Journal ArticleDOI 10.1007/s11307-010-0403-0Authors Roja Rohani, Department of Medical Biophysics, University of Western Ontario, London, Ontario CanadaSonali N. de Chickera, Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario CanadaChristy Willert, BioTherapeutics Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario CanadaYuhua Chen, Imaging Research Laboratories, Robarts Research Institute, University of Western Ontario, London, Ontario CanadaGregory A. Dekaban, BioTherapeutics Research Laboratories, Robarts Research Institute, University of Wes... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3912976 Fri, 27 Aug 2010 17:17:56 +0100 3912976 Early Treatment Response Evaluation in Patients with Diffuse Large B-Cell Lymphoma—A Pilot Study Comparing Volumetric MRI and PET/CT http://www.medworm.com/index.php?rid=3906919&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F38q04484335n661m%2F Conclusions  Standard chemotherapy causes rapid decrease of both tumor metabolic activity and volume as early as 1 week, which continues to decline during therapy. Both volumetric MRI and PET/CT are valuable tools for early treatment response evaluation of aggressive NHL. Content Type Journal ArticleDOI 10.1007/s11307-010-0404-zAuthors Xingchen Wu, Department of Oncology, Tampere University Hospital, Tampere, FinlandPrasun Dastidar, Medical Imaging Centre, Department of Radiology, Tampere University Hospital, Tampere, FinlandHannu Pertovaara, Department of Oncology, Tampere University Hospital, Tampere, FinlandPasi Korkola, Medical Imaging Centre, Department of Nuclear Medicine, Tampere University Hospital, Tampere, FinlandRitva Järvenpää, Medical Imaging Cen... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3906919 Wed, 25 Aug 2010 06:13:36 +0100 3906919 Brain Perfusion in Adult Patients with Acute Myeloblastic Leukemia before and after Cytosine Arabinoside http://www.medworm.com/index.php?rid=3906918&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3423313426738117%2F Conclusions  HMPAO SPECT demonstrated a decrease in thalamus, cerebellar, and parieto-occipital perfusion after conventional doses of ara-C in AML patients, although the neurological examinations were normal and the patients had no neurological adverse effects. Content Type Journal ArticleDOI 10.1007/s11307-010-0409-7Authors Romain Modzelewski, Department of Nuclear Medicine, Henri Becquerel Centre and Rouen University Hospital, University of Rouen, Rouen, FranceStéphane Lepretre, Department of Haematology, Henri Becquerel Centre, Rouen, FranceOlivier Martinaud, Department of Neurology, Rouen University Hospital, Rouen, FranceDidier Hannequin, Department of Neurology, Rouen University Hospital, Rouen, FranceAnne Hitzel, Department of Nuclear Medicine, Henri Becquerel... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3906918 Wed, 25 Aug 2010 06:13:36 +0100 3906918 In Vitro Evaluation of Magnetic Resonance Imaging Contrast Agents for Labeling Human Liver Cells: Implications for Clinical Translation http://www.medworm.com/index.php?rid=3906920&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft304386kj5261142%2F Conclusions  Our findings suggest that MPIO are suited for clinical translation of strategies for cellular imaging with MRI. Attention should be paid to iron release and oxidative stress caused by biodegradable contrast agents. Content Type Journal ArticleDOI 10.1007/s11307-010-0405-yAuthors Nathanael Raschzok, General, Visceral, and Transplantation Surgery, Experimental Surgery and Regenerative Medicine, Charité-Campus Virchow, Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353 GermanyDavid A. Muecke, General, Visceral, and Transplantation Surgery, Experimental Surgery and Regenerative Medicine, Charité-Campus Virchow, Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353 GermanyMichaela K. Adonopoulou, General, Visceral, and Transplant... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3906920 Wed, 25 Aug 2010 06:13:35 +0100 3906920 Quantification of Iron-Labeled Cells with Positive Contrast in Mouse Brains http://www.medworm.com/index.php?rid=3906921&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3437h35253l80388%2F Conclusions  T2* artifact volume imaging (negative or positive) appears promising for the quantification of magnetically labeled cells following focal injection in the brain. Content Type Journal ArticleDOI 10.1007/s11307-010-0402-1Authors Jean-Christophe Brisset, Université de Lyon, Lyon 1, Lyon, 69003 FranceMonica Sigovan, Université de Lyon, Lyon 1, Lyon, 69003 FranceFabien Chauveau, Université de Lyon, Lyon 1, Lyon, 69003 FranceAdrien Riou, Université de Lyon, Lyon 1, Lyon, 69003 FranceEmilie Devillard, Université de Lyon, Lyon 1, Lyon, 69003 FranceVirginie Desestret, Université de Lyon, Lyon 1, Lyon, 69003 FranceMonique Touret, Université de Lyon, Lyon 1, Lyon, 69003 FranceSerge Nataf, Université de Lyon, Lyon 1, Lyon, 69003 FranceJ. Honnorat, Université ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3906921 Tue, 24 Aug 2010 05:53:17 +0100 3906921 Tracking Long-Term Survival of Intramyocardially Delivered Human Adipose Tissue-Derived Stem Cells Using Bioluminescence Imaging http://www.medworm.com/index.php?rid=3898819&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj43l406609w53h77%2F Conclusion  Luciferase-based bioluminescence imaging allows long-term tracking of intramyocardially injected hASCs in living mice. The hASCs might enhance function of injured hearts through long-term engraftment, growth factor secretion, and transdifferentiation to cardiomyocytes and endothelial cells. Content Type Journal ArticleDOI 10.1007/s11307-010-0392-zAuthors Xiaowen Bai, Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, SCRB2, Unit 951, 7435 Fannin Street, Houston, TX 77054, USAYasheng Yan, Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, SCRB2, Unit 951, 7435 Fannin Street, Houston, TX 77054, USAMichael Coleman, InGeneron, Inc., 8275 El Rio, Suite 130, Houston, TX 77054, USAGrace ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3898819 Sat, 21 Aug 2010 05:50:03 +0100 3898819 Biodistribution and Radiation Dosimetry of the Glycine Transporter-1 Ligand 11C-GSK931145 Determined from Primate and Human Whole-Body PET http://www.medworm.com/index.php?rid=3898818&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3835747742550150%2F Conclusion  Human PET imaging of the glycine transporter-1 with 11C-GSK931145 results in a moderate effective human radiation dose, which allows for multiple PET examinations in the same individual. Among the three methods compared to delineate ROIs, the organ subsampling method shows the best balance between quantitative accuracy and practical application. Content Type Journal ArticleDOI 10.1007/s11307-010-0398-6Authors Santiago Bullich, Neurosciences Imaging Group, Molecular Imaging Centre (CRC-CIM), Barcelona Biomedical Research Park, Dr. Aiguader 88, soterrani -1, 08003 Barcelona, SpainMark Slifstein, Department of Psychiatry, Columbia University, New York, USAJan Passchier, Clinical Imaging Centre, GlaxoSmithKline, London, UKN. Venkatesha Murthy, Discovery Medic... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3898818 Sat, 21 Aug 2010 05:50:03 +0100 3898818 In Vivo MRI Tracking of Cell Invasion and Migration in a Rat Glioma Model http://www.medworm.com/index.php?rid=3884768&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F75x180k873200234%2F Conclusion  We successfully demonstrated the ability of MRI to investigate the impact of anatomical structure on the glioma migration pathway in vivo. Content Type Journal ArticleDOI 10.1007/s11307-010-0401-2Authors Fan Zhang, Department of Radiology, Nanjing Jinling Hospital, Clinical School of Medical College of Nanjing University, Nanjing, 210002 ChinaJin Xie, Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USAGang Liu, Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USAYulong He, Model Animal Rese... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3884768 Wed, 18 Aug 2010 06:48:55 +0100 3884768