Molecular Imaging and Biology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Molecular Imaging and Biology' source. Sun, 21 Mar 2010 17:04:33 +0100 AuNP-DG: Deoxyglucose-Labeled Gold Nanoparticles as X-ray Computed Tomography Contrast Agents for Cancer Imaging http://www.medworm.com/index.php?rid=3382226&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F66m4jq5614885753%2F Conclusions  Results from this study demonstrate enhanced uptake of 2-DG-labeled gold nanoparticle by cancer cells in vitro and warrant further experiments to study the exact molecular mechanism by which the AuNP-DG is internalized and retained in the tumor cells. Content Type Journal ArticleCategory Rapid CommunicationDOI 10.1007/s11307-010-0299-8Authors Bulent Aydogan, The University of Chicago Department of Radiation and Cellular Oncology Chicago IL USAJi Li, The University of Chicago Department of Radiation and Cellular Oncology Chicago IL USATijana Rajh, Argonne National Laboratory Center for Nanoscale Materials Argonne IL USAAhmed Chaudhary, The University of Chicago Department of Radiation and Cellular Oncology Chicago IL USASteven J. Chmura, The University of ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3382226 Wed, 17 Mar 2010 15:51:05 +0100 3382226 Effective Reduction of Brown Fat FDG Uptake by Controlling Environmental Temperature Prior to PET Scan: an Expanded Case Series http://www.medworm.com/index.php?rid=3377736&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F167110283j765687%2F Conclusion  In this larger series, CET effectively reduced the false-positive 18FDG uptake in BF on PET scans without the use of drugs. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-010-0298-9Authors Carlos Garcia, Washington Hospital Center Division of Nuclear Medicine, Department of Medicine 110 Irving St, NW Washington DC 20010 USAVaralakshmi Bandaru, Washington Hospital Center Division of Nuclear Medicine, Department of Medicine 110 Irving St, NW Washington DC 20010 USADouglas Van Nostrand, Washington Hospital Center Division of Nuclear Medicine, Department of Medicine 110 Irving St, NW Washington DC 20010 USAShyam Chennupati, Washington Hospital Center Division of Nuclear Medicine, Department of Medicine 110 Irving St, NW Washington DC 20... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3377736 Tue, 16 Mar 2010 14:51:09 +0100 3377736 Welcome to the Future http://www.medworm.com/index.php?rid=3362069&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe521580003x17232%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s11307-010-0326-9Authors Jorge R. Barrio, David Geffen UCLA School of Medicine Department of Molecular and Medical Pharmacology Los Angeles CA USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3362069 Thu, 11 Mar 2010 02:48:31 +0100 3362069 Acquisition Parameters for Oncologic Imaging with a New SPECT/Multislice CT Scanner http://www.medworm.com/index.php?rid=3156062&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9024510487869r73%2F Conclusion  Therefore, this evolving and exciting imaging modality will continue to grow and define its place as an integral part of the evaluation of the cancer patient. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s11307-009-0266-4Authors Rodolfo Núñez, The University of Texas M. D. Anderson Cancer Center Department of Nuclear Medicine, Unit 1264 1515 Holcombe Boulevard P.O. Box 301439 Houston TX 77030-1439 USAWilliam D. Erwin, UT MD Anderson Cancer Center Department of Imaging Physics Houston TX 77030-1439 USARichard E. Wendt, UT MD Anderson Cancer Center Department of Imaging Physics Houston TX 77030-1439 USAAnne Stachowiak, The University of Texas M. D. Anderson Cancer Center Department of Nuclear Medicine, Unit 1264 1515 Holcombe Boulevard P.O... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3156062 Tue, 05 Jan 2010 06:50:23 +0100 3156062 Erratum to: Myocardial Perfusion Imaging is Feasible for Infarct Size Quantification in Mice Using a Clinical Single-photon Emission Computed Tomography System Equipped with Pinhole Collimators http://www.medworm.com/index.php?rid=3156061&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh217mu12g37kg13j%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s11307-009-0297-xAuthors Tim Wollenweber, University of Munich Department of Nuclear Medicine Munich GermanyChristian Zach, University of Munich Department of Nuclear Medicine Munich GermanyChristoph Rischpler, University of Munich Medical Department I, Klinikum Grosshadern Munich GermanyRebekka Fischer, University of Munich Medical Department I, Klinikum Grosshadern Munich GermanySebastian Nowak, University of Munich Department of Nuclear Medicine Munich GermanyStephan G. Nekolla, Technical University Department of Nuclear Medicine Munich GermanyMichael Gröbner, University of Munich Medical Department I, Klinikum Grosshadern Munich GermanyChristopher Übleis, University of Munich Department of Nuclear Medicine Munich GermanyGera... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3156061 Tue, 05 Jan 2010 06:50:23 +0100 3156061 Antioxidants Improve Early Survival of Cardiomyoblasts After Transplantation to the Myocardium http://www.medworm.com/index.php?rid=3099954&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjvww845372194n78%2F Conclusion  Modulation of the local microenvironment (with antioxidants) improves stem cell survival. Increased understanding of the interaction between stem cells and their microenvironment will be critical to advance the field of regenerative medicine. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0274-4Authors Martin Rodriguez-Porcel, Mayo Clinic College of Medicine Division of Cardiovascular Diseases, Department of Internal Medicine Rochester MN USAOlivier Gheysens, University Hospital Leuven Department of Nuclear Medicine Leuven BelgiumRamasamy Paulmurugan, Stanford University Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Division of Nuclear Medicine Stanford CA USAIan Y. Chen, Stanford University Molecular Ima... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3099954 Tue, 15 Dec 2009 07:11:57 +0100 3099954 pcDNA3.1tdTomato Is Superior to pDsRed2-N1 for Optical Fluorescence Imaging in the F344/AY-27 Rat Model of Bladder Cancer http://www.medworm.com/index.php?rid=3099955&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9155352054762372%2F Conclusions   In vivo whole-body imaging of internal red fluorescent animal tumours should use pcDNA3.1tdTomato rather than pDsRed2-N1. Optical imaging of deep-seated organs in larger animals remains a challenge which may require proteins with brighter red or far-red fluorescence and/or alternative approaches. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0275-3Authors Vincent Koo, Queen’s University Belfast Centre for Cancer Research and Cell Biology 97 Lisburn Road Belfast BT9 7BL Northern Ireland UKAlvin Lee, Queen’s University Belfast Centre for Cancer Research and Cell Biology 97 Lisburn Road Belfast BT9 7BL Northern Ireland UKOsama Sharaf Eldin, University College Dublin Health Science Building Dublin IrelandChris Watson, Queen... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3099955 Tue, 15 Dec 2009 07:11:56 +0100 3099955 Degree of Tumor FDG Uptake Correlates with Proliferation Index in Triple Negative Breast Cancer http://www.medworm.com/index.php?rid=3088722&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3p7235k38j0j1x46%2F Conclusions  Degree of tumor FDG uptake correlated significantly with proliferation index in women with triple negative breast cancer suggesting a potential role of FDG-PET in treatment response monitoring for this group of women. Future studies are necessary to define the role of PET imaging as a non-invasive means to monitor breast cancer treatment response in the neoadjuvant setting. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0294-0Authors Julia Tchou, University of Pennsylvania Abramson Cancer Center 3400 Civic Center Boulevard Philadelphia PA 19104 USASeema S. Sonnad, University of Pennsylvania Abramson Cancer Center 3400 Civic Center Boulevard Philadelphia PA 19104 USAMeredith R. Bergey, University of Pennsylvania Department of Su... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3088722 Sat, 12 Dec 2009 14:19:42 +0100 3088722 A Comparison Between Time Domain and Spectral Imaging Systems for Imaging Quantum Dots in Small Living Animals http://www.medworm.com/index.php?rid=3088723&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmj3287140043511v%2F Conclusion  TDI was found to be an order of magnitude more sensitive than SI at the expense of speed and very limited multiplexing capabilities. For deep tissue QD imaging, TDI is most applicable for depths between 2 and 6 mm, as its contrast and resolution degrade the least at these depths. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0290-4Authors Adam de la Zerda, Molecular Imaging Program at Stanford (MIPS), The Bio-X Program Department of Radiology Stanford CA 94305 USASunil Bodapati, Molecular Imaging Program at Stanford (MIPS), The Bio-X Program Department of Radiology Stanford CA 94305 USARobert Teed, Molecular Imaging Program at Stanford (MIPS), The Bio-X Program Department of Radiology Stanford CA 94305 USAMeike L. Schipper... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3088723 Thu, 10 Dec 2009 15:22:52 +0100 3088723 Dual In Vivo Quantification of Integrin-targeted and Protease-activated Agents in Cancer Using Fluorescence Molecular Tomography (FMT) http://www.medworm.com/index.php?rid=3066459&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc6x888828523512t%2F Conclusions  NIRF-labeled integrin antagonists allow noninvasive molecular fluorescent imaging and quantification of tumors in vivo, improving and providing more refined approaches for cancer detection and treatment monitoring. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0279-zAuthors Sylvie Kossodo, VisEn Medical Bedford MA USAMaureen Pickarski, Merck Research Laboratories West Point PA USAShu-An Lin, Merck Research Laboratories West Point PA USAAlexa Gleason, Merck Research Laboratories West Point PA USARenee Gaspar, Merck Research Laboratories West Point PA USAChiara Buono, VisEn Medical Bedford MA USAGuojie Ho, VisEn Medical Bedford MA USAAgnieszka Blusztajn, VisEn Medical Bedford MA USAGarry Cuneo, VisEn Medical Bedford MA USAJun Zhan... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3066459 Fri, 04 Dec 2009 07:21:12 +0100 3066459 MR Reporter Gene Imaging of Endostatin Expression and Therapy http://www.medworm.com/index.php?rid=3066460&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl574014l5l854k42%2F Conclusions  Endostatin therapeutic gene expression was visualized successfully using TfR reporter gene and Tf–USPIO MR reporter probe, which indicates that MR reporter gene imaging may be valuable in gene therapy to evaluate therapeutic gene expression and treatment efficacy. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0286-0Authors Kai Wang, Harbin Medical University Department of Medical Imaging and Nuclear Medicine, the 4th Affiliated Hospital Harbin 150001 ChinaKezheng Wang, Harbin Medical University Department of Medical Imaging and Nuclear Medicine, the 4th Affiliated Hospital Harbin 150001 ChinaBaozhong Shen, Harbin Medical University Department of Medical Imaging and Nuclear Medicine, the 4th Affiliated Hospital Harbin 150001 ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3066460 Thu, 03 Dec 2009 12:53:33 +0100 3066460 Synthesis and Optimization of the Labeling Procedure of 99mTc-Hynic-Interleukin-2 for In vivo Imaging of Activated T lymphocytes http://www.medworm.com/index.php?rid=3056011&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb4khv71r01181462%2F Conclusion  In conclusion, the optimization of 99mTc-HYNIC-IL2 has a great advantage in terms of cost and time of production and a simple kit formulation can be considered for routine application to study patients affected by autoimmune diseases, graft rejection, or other chronic inflammatory disorders. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0285-1Authors Calogero D’Alessandria, University “Sapienza” Nuclear Medicine Unit, 2nd Faculty of Medicine Rome ItalyValentina di Gialleonardo, University “Sapienza” Nuclear Medicine Unit, 2nd Faculty of Medicine Rome ItalyMarco Chianelli, University of Groningen Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen Groningen The NetherlandsStephen J... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3056011 Tue, 01 Dec 2009 08:41:23 +0100 3056011 Volume-Normalized Uptake Rates with Robust Transportability from PET Dual-time and Patlak Analyses http://www.medworm.com/index.php?rid=3056010&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu3r820u0m4466875%2F Conclusion  Two studied physiologically meaningful parameters, close to the diagnostically important k 3, can supplement Ki and enhance Patlak analysis by appropriately utilizing normally ignored information. Hitherto, k 3 was obtainable only by complex nonlinear least squares compartmental model analysis. The additional parameters can have more robust inter-institutional transportability than Ki. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0280-6Authors Joseph A. Thie, University of Tennessee 12334 Bluff Shore Dr. Knoxville TN 37922 USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3056010 Tue, 01 Dec 2009 08:41:23 +0100 3056010 MR Imaging of Inflammation during Myelin-Specific T Cell-Mediated Autoimmune Attack in the EAE Mouse Spinal Cord http://www.medworm.com/index.php?rid=3056013&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj87427h53240lrk4%2F Conclusions  These results demonstrate and provide methodologies for labeling, detecting, and extracting MRI-detectable foci of iron-labeled cells. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0272-6Authors Kristine M. Robinson, V.A. Medical Center VA R&D 23, Bldg 101, 3710 SW US Veteran’s Hospital Rd Portland OR 97239 USAJeffrey M. Njus, Oregon Health & Science University Advanced Imaging Research Center 3181 SW Sam Jackson Park Rd, L452 Portland OR 97239 USADaniel A. Phillips, Oregon Health & Science University Department of Neurology 3181 SW Sam Jackson Park Rd Portland OR 97239 USAThomas M. Proctor, V.A. Medical Center VA R&D 23, Bldg 101, 3710 SW US Veteran’s Hospital Rd Portland OR 97239 USAWilliam D. Rooney, Oregon Health & Scie... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3056013 Tue, 01 Dec 2009 08:41:22 +0100 3056013 18F-Labeled Galacto and PEGylated RGD Dimers for PET Imaging of αvβ3 Integrin Expression http://www.medworm.com/index.php?rid=3056012&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftw22054843tr5827%2F Conclusion  Dimeric RGD peptide tracers with relatively high tumor integrin-specific accumulation and favorable in vivo kinetics may have the potential to be translated into clinic for integrin αvβ3 imaging. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0284-2Authors Shuanglong Liu, Stanford University School of Medicine Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program 1201 Welch Rd., P095 Stanford CA 94305-5484 USAZhaofei Liu, Stanford University School of Medicine Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program 1201 Welch Rd., P095 Stanford CA 94305-5484 USAKai Chen, Stanford University School of Medicine Molecular Imaging Program at Stanford (MIPS), Departmen... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3056012 Tue, 01 Dec 2009 08:41:22 +0100 3056012 Molecular Imaging of the Translocator Protein (TSPO) in a Pre-Clinical Model of Breast Cancer http://www.medworm.com/index.php?rid=3056014&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr67685357h168876%2F Conclusions  NIR-conPK11195 appears to be a promising TSPO-targeted molecular imaging agent for visualization and quantification of breast cancer cells in vivo. This research represents the first study to demonstrate the feasibility of TSPO imaging as an alternative breast cancer imaging approach. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0270-8Authors Shelby K. Wyatt, Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical Center Nashville TN USAH. Charles Manning, Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical Center Nashville TN USAMingfeng Bai, Vanderbilt University Department of Chemistry Nashville TN USAStephanie N. Bailey, Vanderbilt University Departme... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3056014 Tue, 01 Dec 2009 08:41:21 +0100 3056014 Development of a Three-Dimensional In Vitro Model for Longitudinal Observation of Cell Behavior: Monitoring by Magnetic Resonance Imaging and Optical Imaging http://www.medworm.com/index.php?rid=3056015&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh5l1pk2447w43441%2F Conclusions  Through the combination of two-dimensional optical imaging and 3D MRI, the position of individual cell aggregates and their corresponding light emission can be detected. This allows an exact quantification of cell proliferation, with a focus on very small cell amounts (below 100 cells) using high resolution noninvasive techniques as a well-controlled basis for further cell transplantation studies. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0289-xAuthors Klaus Kruttwig, Max-Planck-Institute for Neurological Research In-vivo-NMR-Laboratory Gleuelerstrasse 50 50931 Cologne GermanyChantal Brueggemann, Max-Planck-Institute for Neurological Research In-vivo-NMR-Laboratory Gleuelerstrasse 50 50931 Cologne GermanyEric Kaijzel, Lei... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3056015 Tue, 01 Dec 2009 08:41:20 +0100 3056015 Single-Input–Dual-Output Modeling of Image-Based Input Function Estimation http://www.medworm.com/index.php?rid=3056017&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg477573kx1mp7m0r%2F Conclusions  HSIDO is an improved modeling-based PIF estimation method. This method can be applied for quantitative analysis of small-animal dynamic PET studies. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0273-5Authors Yi Su, Washington University School of Medicine Department of Radiology 510 South Kingshighway Boulevard Campus Box 8225 St. Louis MO 63110 USAKooresh I. Shoghi, Washington University School of Medicine Department of Radiology 510 South Kingshighway Boulevard Campus Box 8225 St. Louis MO 63110 USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3056017 Tue, 01 Dec 2009 08:41:19 +0100 3056017 Performance of Integrated FDG-PET/Contrast-enhanced CT in the Diagnosis of Recurrent Pancreatic Cancer: Comparison with Integrated FDG-PET/Non-contrast-enhanced CT and Enhanced CT http://www.medworm.com/index.php?rid=3056016&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq2871831m8238437%2F Conclusion  PET/contrast-enhanced CT is an accurate modality for assessing recurrence of pancreatic cancer. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0271-7Authors Kazuhiro Kitajima, Dokkyo University School of Medicine Department of Radiology Mibu JapanKoji Murakami, Dokkyo Medical University Hospital PET Center Mibu JapanErena Yamasaki, Dokkyo Medical University Hospital PET Center Mibu JapanYasushi Kaji, Dokkyo University School of Medicine Department of Radiology Mibu JapanMitsugi Shimoda, Dokkyo University School of Medicine Second Department of Surgery Mibu JapanKeiichi Kubota, Dokkyo University School of Medicine Second Department of Surgery Mibu JapanNarufumi Suganuma, Kochi University Medical School Department of Environmental M... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3056016 Tue, 01 Dec 2009 08:41:19 +0100 3056016 Comparison of 2β-Carbomethoxy-3β-(4-[18F]Fluorophenyl)Tropane and N-(3-[18F]Fluoropropyl)-2β-Carbomethoxy-3β-(4-Fluorophenyl)Nortropane, Tracers for Imaging Dopamine Transporter in Rat http://www.medworm.com/index.php?rid=3056018&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy426183764xpt08v%2F Conclusions  Structural modifications of [18F]β-CFT significantly changed its biological properties, as shown by [18F]β-CFT-FP. [18F]β-CFT is a suitable tracer for both preclinical and human PET studies, but [18F]β-CFT-FP is less suitable as a PET tracer. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0278-0Authors Päivi Marjamäki, University of Turku MediCity/PET Preclinical Laboratory, Turku PET Centre Tykistökatu 6A FI-20520 Turku FinlandMerja Haaparanta, University of Turku MediCity/PET Preclinical Laboratory, Turku PET Centre Tykistökatu 6A FI-20520 Turku FinlandSarita Forsback, University of Turku and Åbo Akademi University Radiopharmaceutical Chemistry Laboratory and Accelerator Laboratory, Turku PET Centre Porthaninkatu 3 FI-... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3056018 Tue, 01 Dec 2009 08:41:18 +0100 3056018 Feasibility of Template-Guided Attenuation Correction in Cat Brain PET Imaging http://www.medworm.com/index.php?rid=3056019&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff542762471376738%2F Conclusions  The TGAC was reliable in cat FDG brain PET studies in terms of compatibility with the MAC method. The TGAC might be a useful option for increasing study throughput and decreasing the probability of subject movement. In addition, it might reduce the possible biological effects of long-term anesthesia on the cat brain in investigations using animal-dedicated PET scanners. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0277-1Authors Jin Su Kim, Seoul National University College of Medicine Department of Nuclear Medicine and Interdisciplinary Program in Radiation Applied Life Science Seoul KoreaJae Sung Lee, Seoul National University College of Medicine Department of Nuclear Medicine and Interdisciplinary Program in Radiation Appli... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3056019 Tue, 01 Dec 2009 08:41:17 +0100 3056019 The Prognostic Value of 2-Deoxy-2-[18F]Fluoro-d-Glucose Positron Emission Tomography in Patients With Suspected Residual or Recurrent Medullary Thyroid Carcinoma http://www.medworm.com/index.php?rid=3056020&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7301k70ml0261676%2F Conclusion  FDG-PET has high prognostic value in patients with suspected residual or recurrent MTC. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0276-2Authors Trond Velde Bogsrud, The Norwegian Radium Hospital, Oslo University Hospital Division of Nuclear Medicine, Department of Radiology Oslo NorwayDimitrios Karantanis, Mayo Clinic Division of Nuclear Medicine, Department of Radiology 200 First St SW Rochester MN 55905 USAMark A. Nathan, Mayo Clinic Division of Nuclear Medicine, Department of Radiology 200 First St SW Rochester MN 55905 USABrian P. Mullan, Mayo Clinic Division of Nuclear Medicine, Department of Radiology 200 First St SW Rochester MN 55905 USAGregory A. Wiseman, Mayo Clinic Division of Nuclear Medicine, Department of Radiol... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3056020 Tue, 01 Dec 2009 08:41:16 +0100 3056020 Human Dosimetry of Carbon-11 Labeled N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide Extrapolated from Whole-body Distribution Kinetics and Radiometabolism in Rats http://www.medworm.com/index.php?rid=3043985&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjj3t39110315kngg%2F Conclusions  [11C]PK11195 showed a fast uptake in many rat tissues and it was metabolized relatively fast in vivo, but not in brain in vitro. The estimated effective dose for humans speaks for the use of [11C]PK11195 in human PET imaging. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0293-1Authors Pauliina Luoto, University of Turku Turku PET Center FI-20521 Turku FinlandIina Laitinen, University of Turku Turku PET Center FI-20521 Turku FinlandSami Suilamo, University of Turku Turku PET Center FI-20521 Turku FinlandKjell Någren, University of Turku Turku PET Center FI-20521 Turku FinlandAnne Roivainen, University of Turku Turku PET Center FI-20521 Turku Finland Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3043985 Thu, 26 Nov 2009 08:14:46 +0100 3043985 Achieving Greater Synergy http://www.medworm.com/index.php?rid=3043986&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa4860389841kl23t%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s11307-009-0296-y Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3043986 Thu, 26 Nov 2009 08:14:45 +0100 3043986 In Vivo Bioluminescence Imaging of Murine Xenograft Cancer Models with a Red-shifted Thermostable Luciferase http://www.medworm.com/index.php?rid=3043987&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv8t9171644041264%2F Conclusion  Two different bioluminescent mouse cancer models demonstrate the utility of a new red-shifted thermostable luciferase, Ppy RE-TS, that improved the in vivo imaging performance when compared with wild-type P. Pyralis luciferase. While wild-type luciferase is currently a popular reporter for in vivo imaging methods, this study demonstrates the potential of red-emitting firefly luciferase mutants to enhance the performance of bioluminescence imaging experiments. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0291-3Authors Laura Mezzanotte, University of Bologna Department of Pharmaceutical Sciences Via Belmeloro 6 40126 Bologna ItalyRaffaella Fazzina, University of Bologna Department of Pediatrics, S’Orsola Hospital Bologna Italy... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3043987 Wed, 25 Nov 2009 17:02:01 +0100 3043987 Rodent Rhabdomyosarcoma: Comparison Between Total Choline Concentration at H-MRS and [18F]-fluoromethylcholine Uptake at PET Using Accurate Methods for Collecting Data http://www.medworm.com/index.php?rid=3043988&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl7u154188440473q%2F Conclusion  Total choline concentration did not correlate with FCH uptake in a tumour experimental model. A negative feedback of high values of total choline amount on cellular FCH uptake seemed to be present. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0283-3Authors Denis Rommel, Université Catholique de Louvain Cliniques Universitaires Saint-Luc, Department of Radiology and Medical Imaging Avenue Hippocrate, 10 1200 Brussels BelgiumAnne Bol, Université Catholique de Louvain Center for Molecular Imaging and Experimental Radiotherapy Brussels BelgiumJorge Abarca-Quinones, Université Catholique de Louvain Cliniques Universitaires Saint-Luc, Department of Radiology and Medical Imaging Avenue Hippocrate, 10 1200 Brussels BelgiumFrank Peet... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3043988 Wed, 25 Nov 2009 17:02:00 +0100 3043988 Myocardial Perfusion Imaging is Feasible for Infarct Size Quantification in Mice Using a Clinical Single-photon Emission Computed Tomography System Equipped with Pinhole Collimators http://www.medworm.com/index.php?rid=3043989&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcw86858653226234%2F Conclusions  We achieved a spatial resolution of 1.9 mm in myocardial perfusion imaging in mice using a clinical SPECT system mounted with pinhole collimators. Compared to a histological gold standard, the infarct sizes were accurately estimated, indicating that this method shows promise to monitor experimental cardiac interventions in mice. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0281-5Authors Tim Wollenweber, University of Munich Department of Nuclear Medicine Munich GermanyChristian Zach, University of Munich Department of Nuclear Medicine Munich GermanyChristoph Rischpler, University of Munich Medical Department I, Klinikum Grosshadern Munich GermanyRebekka Fischer, University of Munich Medical Department I, Klinikum Grossha... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3043989 Wed, 25 Nov 2009 17:01:59 +0100 3043989 Rapid and Noninvasive Imaging of Retinal Ganglion Cells in Live Mouse Models of Glaucoma http://www.medworm.com/index.php?rid=3033327&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm363x14k75021475%2F Conclusions  Our live-imaging technique allows for the longitudinal assessment of RGC survival from the same animal. Noninvasive monitoring of neuronal cell death and survival is a powerful technique that would allow investigators to validate new potential glaucoma therapy based on neuroprotection. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0292-2Authors Joaquin Tosi, Columbia University Bernard and Shirlee Brown Glaucoma Laboratory, Departments of Ophthalmology, Pathology and Cell Biology 630 West 168th Street Box 18 New York NY 10032 USANan-Kai Wang, Columbia University Bernard and Shirlee Brown Glaucoma Laboratory, Departments of Ophthalmology, Pathology and Cell Biology 630 West 168th Street Box 18 New York NY 10032 USAJin Zhao, C... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3033327 Tue, 24 Nov 2009 07:14:11 +0100 3033327 Sunflower Trypsin Inhibitor 1 Derivatives as Molecular Scaffolds for the Development of Novel Peptidic Radiopharmaceuticals http://www.medworm.com/index.php?rid=3033328&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F541756373038u4x3%2F Conclusions  SFTI derivatives are small stable molecules readily accessible by solid-phase synthesis. The trypsin inhibition was not influenced by the cyclization, and addition of a chelator had no significant influence. The exceptional rigidity and stability allow the use of SFTI derivatives as scaffolds for the introduction of tumor-specific peptide motifs which could be used to increase cell-binding affinities and thus their use as diagnostic and/or therapeutic tools. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0287-zAuthors Regine García Boy, University of Heidelberg Department of Nuclear Medicine Im Neuenheimer Feld 400 69120 Heidelberg GermanyWalter Mier, University of Heidelberg Department of Nuclear Medicine Im Neuenheimer Feld... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3033328 Tue, 24 Nov 2009 07:14:09 +0100 3033328 Fluorescence Imaging and Whole-Body Biodistribution of Near-Infrared-Emitting Quantum Dots after Subcutaneous Injection for Regional Lymph Node Mapping in Mice http://www.medworm.com/index.php?rid=3022485&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgm7840971m684075%2F Conclusions  Fluorescence imaging can be used as a non-invasive alternative to ICP–MS to follow the QD accumulation kinetics into regional LNs. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0288-yAuthors Emilie Pic, Centre de Recherche en Automatique de Nancy—Nancy-University—CNRS—Centre Alexis Vautrin avenue de Bourgogne 54511 Vandoeuvre-lès-Nancy Cedex FranceThomas Pons, CNRS UPRA0005, ESPCI Laboratoire Photons et Matière 10 rue Vauquelin 75005 Paris FranceLina Bezdetnaya, Centre de Recherche en Automatique de Nancy—Nancy-University—CNRS—Centre Alexis Vautrin avenue de Bourgogne 54511 Vandoeuvre-lès-Nancy Cedex FranceAgnès Leroux, Centre Alexis Vautrin Department of Pathology avenue de Bourgogne 54511 Vandoeuvre-lès-Nan... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3022485 Sat, 21 Nov 2009 09:50:01 +0100 3022485 Imaging of Gadolinium Spatial Distribution in Tumor Tissue by Laser Ablation Inductively Coupled Plasma Mass Spectrometry http://www.medworm.com/index.php?rid=3011779&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc284280v64064751%2F Conclusions  We have demonstrated, in a novel manner, the use of LA–ICP–MS for the spatial detection of Gd in tumor tissue. LA–ICP–MS is valuable in providing spatio-specific information of MRI contrast agents and more importantly Gd in tumor tissue. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0282-4Authors Nazila Kamaly, Hammersmith Hospital, Imperial College London Imaging Sciences Department, Metabolic and Molecular Imaging Group, MRC Clinical Sciences Center London W12 0NN UKJohn A. Pugh, University of Sheffield Department of Chemistry, Center for Analytical Sciences Sheffield UKTammy L. Kalber, Hammersmith Hospital, Imperial College London Imaging Sciences Department, Metabolic and Molecular Imaging Group, MRC Clinical Sciences ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3011779 Tue, 17 Nov 2009 23:39:55 +0100 3011779 High Impact of 18F-FDG-PET on Management and Prognostic Stratification of Newly Diagnosed Small Cell Lung Cancer http://www.medworm.com/index.php?rid=3011780&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu826wk64827l9q18%2F Conclusion  PET had a major impact on stage classification, management, and prognostic stratification of newly diagnosed SCLC. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0295-zAuthors Arun Azad, Ludwig Institute Oncology Unit, Austin Health Heidelberg AustraliaFiona Chionh, Ludwig Institute Oncology Unit, Austin Health Heidelberg AustraliaAndrew M. Scott, Centre for Positron Emission Tomography, Austin Health Melbourne AustraliaSzeting T. Lee, Centre for Positron Emission Tomography, Austin Health Melbourne AustraliaSam U. Berlangieri, Centre for Positron Emission Tomography, Austin Health Melbourne AustraliaShane White, Ludwig Institute Oncology Unit, Austin Health Heidelberg AustraliaPaul L. Mitchell, Ludwig Institute Oncology Unit, Aus... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3011780 Tue, 17 Nov 2009 23:39:54 +0100 3011780 High-Affinity αvβ3 Integrin Targeted Optical Probe as a New Imaging Biomarker for Early Atherosclerosis: Initial Studies in Watanabe Rabbits http://www.medworm.com/index.php?rid=2976817&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1842182880j1513r%2F Conclusions  This high-affinity ITOP identifies the site and extent of αvβ3 expression and correlates with adventitial thickness. Recent evidence associates αvβ3 expression with the inflammatory process in early vulnerable plaque, making this compound a promising potential biomarker for early atherosclerotic disease. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0242-zAuthors Julie Heroux, National Institute of Diabetes Digestive and Kidney Diseases Laboratory of Integrative Cardiovascular Imaging Science Bethesda MD 20892 USAAhmed M. Gharib, National Institute of Diabetes Digestive and Kidney Diseases Laboratory of Integrative Cardiovascular Imaging Science Bethesda MD 20892 USANarasimhan S. Danthi, Clinical Center Laboratory of Diagnost... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2976817 Sat, 07 Nov 2009 07:40:57 +0100 2976817 Introduction to the Proceedings of the 2nd World Molecular Imaging Congress http://www.medworm.com/index.php?rid=2962709&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq05p720428347264%2F Content Type Journal ArticleDOI 10.1007/s11307-009-0253-9 Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2962709 Tue, 03 Nov 2009 14:01:46 +0100 2962709 Proceedings of the 2009 World Molecular Imaging Congress Montreal, Canada, September 23–26 http://www.medworm.com/index.php?rid=2962708&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1752363466078232%2F Content Type Journal ArticleDOI 10.1007/s11307-009-0251-y Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2962708 Tue, 03 Nov 2009 14:01:46 +0100 2962708 Author Index http://www.medworm.com/index.php?rid=2962710&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg35q67t63135n3xj%2F Content Type Journal ArticleDOI 10.1007/s11307-009-0252-x Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2962710 Tue, 03 Nov 2009 14:01:44 +0100 2962710 In Vivo Imaging of Sentinel Nodes Using Fluorescent Silica Nanoparticles in Living Mice http://www.medworm.com/index.php?rid=2908113&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fntn484h3n575128h%2F Conclusion  Our data provide strong evidence that functionalized silica nanoparticles has a promising potential as organic lymphatic tracer in biomedical imaging such as pre- and intraoperative surgical guidance. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0262-8Authors Yong Hyun Jeon, Seoul National University College of Medicine Department of Nuclear Medicine 28 Yongon-dong, Jongno-gu Seoul 110-744 South KoreaYoung-Hwa Kim, Seoul National University Department of Laboratory of Molecular Imaging and Therapy of Cancer Research Institute Seoul South KoreaKihwan Choi, Seoul National University Department of Chemistry Seoul 151-747 South KoreaJing Yu Piao, Seoul National University Department of Chemistry Seoul 151-747 South KoreaBo Quan, Se... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2908113 Thu, 15 Oct 2009 05:56:01 +0100 2908113 Diagnostic Performance of FDG-PET, MRI, and Plain Film Radiography (PFR) for the Diagnosis of Osteomyelitis in the Diabetic Foot http://www.medworm.com/index.php?rid=2881079&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1965188135931702%2F Conclusion  FDG-PET is a highly specific imaging modality for the diagnosis of osteomyelitis in diabetic foot and, therefore, should be considered to be a useful complimentary imaging modality with MRI. In the setting where MRI is contraindicated, the high sensitivity and specificity of FDG-PET justifies its use after a negative or inconclusive PFR to aid an accurate diagnosis. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0268-2Authors Asad Nawaz, Department of Radiology, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania Division of Nuclear Medicine 3400 Spruce Street Philadelphia PA 19104 USADrew A. Torigian, Department of Radiology, University of Pennsylvania School of Medicine, Hospital of the Un... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2881079 Fri, 09 Oct 2009 06:13:30 +0100 2881079 On the Added Value of Baseline FDG-PET in Malignant Lymphoma http://www.medworm.com/index.php?rid=2875211&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj31u1pj2w8207155%2F Conclusion  Without any other clinical information, pretreatment PET facilitates changes the interpretation of a posttreatment PET in a third of the patients, resulting in both upgrading and downgrading of the posttreatment situation of a malignant lymphoma patient. If these results are confirmed for PET–computed tomography systems, they favor the addition of baseline PET to the current work-up of patients with malignant lymphoma. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0259-3Authors Henriette Quarles van Ufford, University Medical Center Utrecht Radiology Utrecht The NetherlandsOtto Hoekstra, Vrije University Medical Center Nuclear Medicine & PET research Amsterdam The NetherlandsMarie de Haas, Meander Medical Center Nuclear Medi... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2875211 Wed, 07 Oct 2009 07:35:19 +0100 2875211 Two-Step In Vivo Tumor Targeting by Biotin-Conjugated Antibodies and Superparamagnetic Nanoparticles Assessed by Magnetic Resonance Imaging at 1.5 T http://www.medworm.com/index.php?rid=3099956&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq5w15392p3351163%2F Conclusion  MRI at 1.5 T can detect tumors by a two-step in vivo biotin-based protocol, which may allow the targeting of any cell surface antigen. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0264-6Authors Gabriella Baio, National Cancer Institute Department of Diagnostic Imaging, IST Largo Rosanna Benzi 10 16132 Genoa ItalyMarina Fabbi, National Cancer Institute Unit of Immunological Therapy, IST Largo Rosanna Benzi 10 16132 Genoa ItalySandra Salvi, National Cancer Institute Department of Pathology, IST Largo Rosanna Benzi 10 16132 Genoa ItalyDaniela de Totero, National Cancer Institute Unit of Immunological Therapy, IST Largo Rosanna Benzi 10 16132 Genoa ItalyMauro Truini, National Cancer Institute Department of Pathology, IST Largo ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=3099956 Tue, 06 Oct 2009 12:50:42 +0100 3099956 Two-Step In Vivo Tumor Targeting by Biotin-Conjugated Antibodies and Superparamagnetic Nanoparticles Assessed by Magnetic Resonance Imaging at 1.5 T http://www.medworm.com/index.php?rid=2871204&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq5w15392p3351163%2F Conclusion  MRI at 1.5 T can detect tumors by a two-step in vivo biotin-based protocol, which may allow the targeting of any cell surface antigen. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0264-6Authors Gabriella Baio, National Cancer Institute Department of Diagnostic Imaging, IST Largo Rosanna Benzi 10 16132 Genoa ItalyMarina Fabbi, National Cancer Institute Unit of Immunological Therapy, IST Largo Rosanna Benzi 10 16132 Genoa ItalySandra Salvi, National Cancer Institute Department of Pathology, IST Largo Rosanna Benzi 10 16132 Genoa ItalyDaniela de Totero, National Cancer Institute Unit of Immunological Therapy, IST Largo Rosanna Benzi 10 16132 Genoa ItalyMauro Truini, National Cancer Institute Department of Pathology, IST Largo ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2871204 Tue, 06 Oct 2009 12:50:42 +0100 2871204 Detection of Experimentally Induced Pulmonary Granuloma Inflammation in Monocyte Chemoattractant Protein-1 Reporter Mice http://www.medworm.com/index.php?rid=2871205&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgu53712w55632134%2F Conclusions  By using a pulmonary granuloma model, we showed that EGFP transgene reporter expression in MCP-1-EGFP mouse was correlated to the endogenous MCP-1 induction. The establishment of this mouse model will provide a valuable tool for monitoring the activation of monocytes/macrophages and facilitate the studies on the roles of MCP-1 gene in various inflammatory diseases. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0261-9Authors Subbiah Rajasekaran, National Health Research Institutes Division of Medical Engineering Research Zhunan Town Miaoli County Taiwan Republic of ChinaVivia Yu-Ying Kao, Chia Nan University of Pharmacy and Science Department of Biotechnology Tainan Taiwan Republic of ChinaMei-Ru Chen, National Health Research ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2871205 Tue, 06 Oct 2009 12:50:41 +0100 2871205 Quantitative Assessment of the Hepatic Metabolic Volume Product in Patients with Diffuse Hepatic Steatosis and Normal Controls Through Use of FDG-PET and MR Imaging: A Novel Concept http://www.medworm.com/index.php?rid=2871206&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F045g627742h8245n%2F Conclusion  The increase in HMVP is the result of increased hepatic metabolic activity likely related to the diffuse hepatic steatosis. The active inflammatory process related to the diffuse hepatic steatosis is the probable explanation for the increase in hepatic metabolic activity on FDG-PET study. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0258-4Authors Gonca G. Bural, Hospital of the University of Pennsylvania Division of Nuclear Medicine, Department of Radiology 3400 Spruce Street, 110 Donner Bldg. Philadelphia PA 19104 USADrew A. Torigian, Hospital of the University of Pennsylvania Division of Nuclear Medicine, Department of Radiology 3400 Spruce Street, 110 Donner Bldg. Philadelphia PA 19104 USAAnne Burke, Hospital of the University... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2871206 Tue, 06 Oct 2009 12:50:40 +0100 2871206 A Novel Fluorescent Imaging Agent for Diffuse Optical Tomography of the Breast: First Clinical Experience in Patients http://www.medworm.com/index.php?rid=2865177&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa676k2592t2j698n%2F Conclusions  Lowest doses of Omocianine performed best in lesion detection; DOT using a low-dose fluorescent agent is feasible and safe for breast cancer visualization in patients. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0269-1Authors Stephanie van de Ven, University Medical Center Utrecht Department of Radiology Utrecht The NetherlandsAndrea Wiethoff, Philips Healthcare Best The NetherlandsTim Nielsen, Philips Research Europe Eindhoven The NetherlandsBernhard Brendel, Philips Research Europe Eindhoven The NetherlandsMarjolein van der Voort, Philips Research Europe Philips Research, Biomedical Photonics Eindhoven The NetherlandsRami Nachabe, Philips Research Europe Eindhoven The NetherlandsMartin Van der Mark, Philips Research Europe ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2865177 Fri, 02 Oct 2009 05:47:13 +0100 2865177 68Ga-Chloride PET Reveals Human Pancreatic Adenocarcinoma Xenografts in Rats—Comparison with FDG http://www.medworm.com/index.php?rid=2865178&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr811113h22848m61%2F Conclusions   68Ga-chloride delineated subcutaneously implanted pancreatic adenocarcinoma xenografts by PET, but the uptake was lower than FDG. Further studies to clarify the value of 68Ga-chloride for PET imaging of tumors are warranted. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0267-3Authors Tiina Ujula, Turku University Hospital Turku PET Centre 20521 Turku FinlandSatu Salomäki, Turku University Hospital Turku PET Centre 20521 Turku FinlandAnu Autio, Turku University Hospital Turku PET Centre 20521 Turku FinlandPauliina Luoto, Turku University Hospital Turku PET Centre 20521 Turku FinlandTuula Tolvanen, Turku University Hospital Turku PET Centre 20521 Turku FinlandPertti Lehikoinen, Turku PET Centre Radiopharmaceutical Chemistry La... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2865178 Fri, 02 Oct 2009 05:47:12 +0100 2865178 COMT Val158Met Genotype Does Not Alter Cortical or Striatal Dopamine D2 Receptor Availability In Vivo http://www.medworm.com/index.php?rid=2857193&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn037k7472243561r%2F Conclusions  COMT genotype is not related with alterations in baseline D2 receptor availability in vivo in the cortex or the striatum. This information is useful for the interpretation of genetic studies on COMT in neuropsychiatry. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0257-5Authors Mika M. Hirvonen, University of Turku Department of Pharmacology, Drug Development and Therapeutics 20014 Turku FinlandKjell Någren, Turku University Hospital Turku PET Centre 20014 Turku FinlandJuha O. Rinne, Turku University Hospital Turku PET Centre 20014 Turku FinlandUllamari Pesonen, University of Turku Department of Pharmacology, Drug Development and Therapeutics 20014 Turku FinlandTero Vahlberg, University of Turku Department of Biostatistics 2001... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2857193 Wed, 30 Sep 2009 18:20:47 +0100 2857193 In Vivo Fluorescence Imaging is Well-Suited for the Monitoring of Adenovirus Directed Transgene Expression in Living Organisms http://www.medworm.com/index.php?rid=2855024&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2n275g35l6670286%2F Conclusions  These findings demonstrate that in vivo fluorescence imaging provides functional data indicating the approximate location, magnitude, and duration of AdEGFP expression. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0260-xAuthors Sevim Kahraman, Akdeniz University Human Gene Therapy Division, Faculty of Medicine Antalya 07070 TurkeyErcument Dirice, Akdeniz University Human Gene Therapy Division, Faculty of Medicine Antalya 07070 TurkeyAhter Dilsad Sanlioglu, Akdeniz University Human Gene Therapy Division, Faculty of Medicine Antalya 07070 TurkeyBurcak Yoldas, Akdeniz University Human Gene Therapy Division, Faculty of Medicine Antalya 07070 TurkeyHuseyin Bagci, Akdeniz University Human Gene Therapy Division, Faculty of Medicine An... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2855024 Wed, 30 Sep 2009 06:27:03 +0100 2855024 [11C]Gefitinib ([11C]Iressa): Radiosynthesis, In Vitro Uptake, and In Vivo Imaging of Intact Murine Fibrosarcoma http://www.medworm.com/index.php?rid=2850943&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8r6g1r1r352mv578%2F Conclusion  These results demonstrated the promising potential of [11C]gefitinib to serve as a PET ligand for in vivo imaging of NFSa-bearing mice. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0265-5Authors Ming-Rong Zhang, National Institute of Radiological Sciences Department of Molecular Probes, Molecular Imaging Center 4-9-1 Anagawa, Inage-ku Chiba JapanKatsushi Kumata, National Institute of Radiological Sciences Department of Molecular Probes, Molecular Imaging Center 4-9-1 Anagawa, Inage-ku Chiba JapanAkiko Hatori, National Institute of Radiological Sciences Department of Molecular Probes, Molecular Imaging Center 4-9-1 Anagawa, Inage-ku Chiba JapanNobuhiko Takai, National Institute of Radiological Sciences Heavy-Ion Radiobiology Rese... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2850943 Tue, 29 Sep 2009 01:05:47 +0100 2850943 Development and Validation of a Monte Carlo Simulation Tool for Multi-Pinhole SPECT http://www.medworm.com/index.php?rid=2836051&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F063242t727282gl6%2F Conclusions  The new method is useful for studying MPH collimator designs, data acquisition protocols, image reconstructions, and compensation techniques. It also has great potential to be applied for modeling the collimator-detector response with penetration and scatter effects for MPH in the quantitative reconstruction method. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0263-7Authors Greta S. P. Mok, The Chinese University of Hong Kong Department of Diagnostic Radiology and Organ Imaging Shatin N.T. Hong KongYong Du, Johns Hopkins University Division of Medical Imaging Physics, The Russell H. Morgan Department of Radiology and Radiological Science Baltimore MD 21287 USAYuchuan Wang, Dana Farber Cancer Institute Radiology and Nuclear Me... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2836051 Fri, 25 Sep 2009 05:47:43 +0100 2836051 64Cu-Labeled Affibody Molecules for Imaging of HER2 Expressing Tumors http://www.medworm.com/index.php?rid=2836052&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff402126762515418%2F This study demonstrates that 64Cu-labeled ZHER2:477 is a promising targeted molecular probe for imaging HER2 receptor expression in living mice. Further work is needed to improve the excretion properties, hence dosimetry and imaging efficacy, of the radiometal-based probe. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0256-6Authors Zhen Cheng, Stanford University Molecular Imaging Program at Stanford (MIPS), Departments of Radiology and Bioengineering, Bio-X Program California CA 94305-5344 USAOmayra Padilla De Jesus, Global Research Center General Electric Company Niskayuna NY 12309 USADaniel J. Kramer, Global Research Center General Electric Company Niskayuna NY 12309 USAAbhijit De, Stanford University Molecular Imaging Program at Stanford (MIPS), ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2836052 Fri, 25 Sep 2009 05:47:42 +0100 2836052 Predicting Early Chemotherapy Response with Technetium-99m Methoxyisobutylisonitrile SPECT/CT in Advanced Non-Small Cell Lung Cancer http://www.medworm.com/index.php?rid=2812137&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnj523851452171k1%2F Conclusions  Our series demonstrated solid, negative correlations between prechemotherapy 99mTc-MIBI uptake and tumor size change measured by CT for advanced NSCLC, particularly with C mean and 1D change. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0250-zAuthors Tzu-I J. Yang, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital Department of Radiotherapy Plesmanlaan 121 1066 CX Amsterdam The NetherlandsTjeerd S. Aukema, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital Department of Nuclear Medicine Amsterdam The NetherlandsHarm van Tinteren, The Netherlands Cancer Institute–Antoni van Leeuwenhoek Hospital Biometrics Department Amsterdam The NetherlandsSjaak Burgers, The Netherlands Cancer Institute–Ant... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2812137 Tue, 15 Sep 2009 20:44:40 +0100 2812137 Letter to the Editor http://www.medworm.com/index.php?rid=2768382&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw3802724pn167841%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s11307-009-0254-8Authors Victor H. Gerbaudo, Harvard Medical School Division of Nuclear Medicine and Molecular Imaging, Brigham & Women’s Hospital Boston MA USAScott Britz-Cunningham, Harvard Medical School Division of Nuclear Medicine and Molecular Imaging, Brigham & Women’s Hospital Boston MA USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2768382 Thu, 03 Sep 2009 06:33:33 +0100 2768382 Letter to the Editor http://www.medworm.com/index.php?rid=2740883&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp77321846lxm4h05%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s11307-009-0255-7Authors Sze Ting Lee, Austin Hospital Nuclear Medicine Physician, Centre for PET, Austin Health Level 1, Harold Stokes Building, Burgundy Street Heidelberg Victoria 3084 Australia Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2740883 Wed, 26 Aug 2009 08:45:15 +0100 2740883 Surface Feature-Guided Mapping of Cerebral Metabolic Changes in Cognitively Normal and Mildly Impaired Elderly http://www.medworm.com/index.php?rid=2653259&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxm330t65845x2157%2F Conclusions  Using 3-D surface-based MR-guided FDG-PET mapping, significant metabolic changes were seen in five posterior and the left lateral frontal regions. The changes were more pronounced for the declining relative to the cognitively stable group. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0247-7Authors Liana G. Apostolova, David Geffen School of Medicine, UCLA Department of Neurology 10911 Weyburn Ave, 2nd floor Los Angeles CA 90095 USAPaul M. Thompson, David Geffen School of Medicine, UCLA Department of Neurology 10911 Weyburn Ave, 2nd floor Los Angeles CA 90095 USASteve A. Rogers, Westmont College Santa Barbara CA USAIvo D. Dinov, David Geffen School of Medicine, UCLA Laboratory of Neuroimaging Los Angeles CA USACharleen Zoumalan... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2653259 Tue, 28 Jul 2009 06:15:10 +0100 2653259 Dynamic Contrast-Enhanced Folate-Receptor-Targeted MR Imaging Using a Gd-loaded PEG-Dendrimer–Folate Conjugate in a Mouse Xenograft Tumor Model http://www.medworm.com/index.php?rid=2653258&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxq454556r1mr3221%2F Conclusions  We have demonstrated the targeting ability of PEG-G3-(Gd-DTPA)11-(folate)5 in vitro and in vivo. A 17% cut-off point for a 30-min washout percentage can be a useful parameter for the diagnosis of FR-positive tumors. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0248-6Authors Wei-Tsung Chen, Taipei City Hospital Department of Radiology Taipei TaiwanDhakshanamurthy Thirumalai, Industrial Technology Research Institute Union Chemical Laboratory Hsinchu TaiwanTiffany Ting-Fang Shih, National Taiwan University Department of Radiology, School of Medicine Taipei TaiwanRan-Chou Chen, Taipei City Hospital Department of Radiology Taipei TaiwanShin-Yang Tu, Taipei City Hospital Department of Radiology Taipei TaiwanChin-I Lin, Industrial Tec... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2653258 Tue, 28 Jul 2009 06:15:10 +0100 2653258 Additional Value of FDG-PET/CT in Management of “Solitary” Liver Metastases: Preliminary Results of a Prospective Multicenter Study http://www.medworm.com/index.php?rid=2644646&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj30636032203m631%2F Conclusion  The addition of FDG-PET/CT to the routine assessment of patients with liver metastasis has a significant impact on disease staging and selection of suitable candidates for solitary liver metastasis resection and outcome. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0249-5Authors Gaia Grassetto, ‘Santa Maria della Misericordia’ Hospital Department of Nuclear Medicine, Medical Physics, Radiology, PET Centre Viale Tre Martiri, 140 45100 Rovigo ItalyAdriano Fornasiero, General Hospital Department of Oncology Piove di Sacco Padua ItalyGiorgio Bonciarelli, General Hospital of Este-Monselice Department of Oncology Padua ItalyElena Banti, ‘Santa Maria della Misericordia’ Hospital Department of Nuclear Medicine, Medical Physics, Ra... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2644646 Fri, 24 Jul 2009 23:42:32 +0100 2644646 The Use of F-18 Choline PET in the Assessment of Bone Metastases in Prostate Cancer: Correlation with Morphological Changes on CT http://www.medworm.com/index.php?rid=2592954&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F52r6013581549082%2F Conclusion  FCH-PET/CT showed promising results for the early detection of bone metastases in prostate cancer patients. We have found that a HU level of above 825 is associated with an absence of FCH uptake. Almost all of the FCH-negative sclerotic lesions were detected in patients who were under hormone therapy, which raises the possibility that these lesions might no longer be viable. However, clarification and the prognostic value of such lesions require further research. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0239-7Authors Mohsen Beheshti, St. Vincent’s Hospital—Nuclear Medicine & Endocrinology PET/CT Center Linz Linz AustriaReza Vali, St. Vincent’s Hospital—Nuclear Medicine & Endocrinology PET/CT Center Linz Linz Austr... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2592954 Thu, 09 Jul 2009 12:46:38 +0100 2592954 Modification of Aminosilanized Superparamagnetic Nanoparticles: Feasibility of Multimodal Detection Using 3T MRI, Small Animal PET, and Fluorescence Imaging http://www.medworm.com/index.php?rid=2590961&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6r074251u4x70822%2F Conclusions  We conclude that our modified superparamagnetic nanoparticles are stable under in vitro and in vivo conditions and are therefore applicable for efficient cell labeling and subsequent multimodal molecular imaging. Moreover, their multiple free amino groups suggest the possibility for further modifications and might provide interesting opportunities for various research fields. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0237-9Authors Lars Stelter, Universitätsmedizin Berlin Klinik für Strahlenheilkunde, CC6, Charité Campus Virchow-Klinikum Augustenburger Platz 1 13353 Berlin GermanyJens G. Pinkernelle, Universitätsmedizin Berlin Klinik für Strahlenheilkunde, CC6, Charité Campus Virchow-Klinikum Augustenburger Platz 1 13... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2590961 Tue, 07 Jul 2009 14:51:15 +0100 2590961 Evaluation of the Radiocobalt-Labeled [MMA-DOTA-Cys61]-ZHER2:2395-Cys Affibody Molecule for Targeting of HER2-Expressing Tumors http://www.medworm.com/index.php?rid=2550146&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F43u7663gqgrk7365%2F Conclusions  Radiocobalt is a promising label for affibody molecules for future PET applications. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0238-8Authors Helena Wållberg, Affibody AB Bromma SwedenSara Ahlgren, Uppsala University Division of Nuclear Medicine, Department of Medical Sciences Uppsala SwedenCharles Widström, Uppsala University Hospital Hospital Physics, Department of Oncology Uppsala SwedenAnna Orlova, Affibody AB Bromma Sweden Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2550146 Fri, 26 Jun 2009 05:55:53 +0100 2550146 Comparison of Gene-Transfer Efficiency in Human Embryonic Stem Cells http://www.medworm.com/index.php?rid=2516884&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu188142273j10544%2F In this study, a bi-fusion construct with ubiquitin promoter driving enhanced green fluorescent protein reporter and the firefly luciferase (pUb-eGFP-Fluc) along with neomycin selection marker was used for in vitro and in vivo studies. In vitro studies examined the transfection efficiency and viability of each technique using two hES cell lines (male H1 and female H9 cells). Lentiviral transduction demonstrated the highest efficiency (H1: 25.3 ± 4.8%; H9: 22.4 ± 6.5%) with >95% cell viability. Nucleofection demonstrated transfection efficiency of 16.1 ± 3.6% (H1) and 5.8 ± 3.2% (H9). However, minimal transfection efficiency was observed with electroporation (2.1 ± 0.4% (H1) and 1.9 ± 0.3% (H9)) and lipofection (1.5 ± 0.5% (H1) and 1.3 ± 0.2% ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2516884 Wed, 24 Jun 2009 06:08:20 +0100 2516884 Involvement of Nigrostriatal Pathway in Japanese Encephalitis with Movement Disorders: Evidence from 99mTc-TRODAT-1 and 123I-IBZM SPECT Imagings http://www.medworm.com/index.php?rid=2504309&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh77pw26642x794q3%2F Conclusion  Data have suggested that presynaptic dopaminergic neurons in JE patients are more susceptible to JE virus than postsynaptic striatal neurons. The degree of movement impairment was more closely correlated to the degree of D2Rs disruption seen in 123I-IBZM SPECT imaging. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0244-xAuthors Chang-Hsu Liao, Tri-Service General Hospital, National Defense Medical Center Department of Neurology Cheng-Kung Rd Section 2 Taipei 114 Taiwan Republic of ChinaZaodung Ling, National Health Research Institutes Division of Mental Health and Substance Abuse Research Taipei Taiwan Republic of ChinaChung-Hsing Chou, Tri-Service General Hospital, National Defense Medical Center Department of Neurology Cheng-Kun... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2504309 Tue, 23 Jun 2009 06:06:50 +0100 2504309 Bioluminescence Imaging in Mouse Models Quantifies β Cell Mass in the Pancreas and After Islet Transplantation http://www.medworm.com/index.php?rid=2504310&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F14365xg8030x5358%2F Conclusions  Bioluminescence in the MIP-Luc-VU mouse model is proportional to β cell mass in the setting of increased and decreased β cell mass and after transplantation. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0240-1Authors John Virostko, Vanderbilt University Institute of Imaging Science Nashville TN USAAramandla Radhika, Vanderbilt University Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism Nashville TN USAGreg Poffenberger, Vanderbilt University Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism Nashville TN USAZhongyi Chen, Vanderbilt University Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism Nashville TN USAMarcela Brissova, Vanderbilt University D... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2504310 Tue, 23 Jun 2009 06:06:48 +0100 2504310 131I-Tositumomab (Bexxar®) vs.90Y-Ibritumomab (Zevalin®) Therapy of Low-Grade Refractory/Relapsed Non-Hodgkin Lymphoma http://www.medworm.com/index.php?rid=2504311&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F004w910303844568%2F Conclusion  Our study suggests that clinical practice of Bexxar® and Zevalin® radioimmunotherapy is an effective and safe adjunctive treatment for patients with NHL refractory/relapsed to conventional treatment. However, due to the small number of subjects, it was not possible to determine whether differences in the outcomes or toxicities from the two agents were statistically significant. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0245-9Authors Andrei Iagaru, Stanford University Medical Center Division of Nuclear Medicine 300 Pasteur Dr, Room H-0101 Stanford CA 94305 USAErik S. Mittra, Stanford University Medical Center Division of Nuclear Medicine 300 Pasteur Dr, Room H-0101 Stanford CA 94305 USAKristen Ganjoo, Stanford University M... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2504311 Sat, 20 Jun 2009 06:04:02 +0100 2504311 Incremental Value of Integrated FDG-PET/CT in Evaluating Indeterminate Solitary Pulmonary Nodule for Malignancy http://www.medworm.com/index.php?rid=2504312&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx00458763581j708%2F Conclusions  Although the benefit attributable to the CT component was limited when integrated PET/CT was used, PET and CT acted synergistically to significantly increase the diagnostic veracity for PET-indeterminate nodules. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0241-0Authors Chih-Yung Chang, Tri-Service General Hospital Department of Nuclear Medicine National Defense Medical Center, 325, Section 2, Cheng-Kung Road Taipei 114 TaiwanChing Tzao, Tri-Service General Hospital Department of Thoracic Surgery Taipei TaiwanShih-Chun Lee, Tri-Service General Hospital Department of Thoracic Surgery Taipei TaiwanCheng-Yi Cheng, Tri-Service General Hospital Department of Nuclear Medicine National Defense Medical Center, 325, Section 2, Cheng... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2504312 Sat, 20 Jun 2009 06:03:59 +0100 2504312 Dual Tracer 11C-Choline and FDG-PET in the Diagnosis of Biochemical Prostate Cancer Relapse After Radical Treatment http://www.medworm.com/index.php?rid=2504314&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft107r50856764551%2F Conclusions   A PSA value higher than 1.9 ng/ml determines a significant increase in the diagnostic yield. Adjuvant hormonotherapy has no influence on the PET results. FDG has a better correlation with the Gleason score than 11C-choline. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0243-yAuthors José A. Richter, Universidad de Navarra Nuclear Medicine Department, Clínica Universitaria Avda, Pío XII 36 31008 Pamplona SpainMacarena Rodríguez, Universidad de Navarra Nuclear Medicine Department, Clínica Universitaria Avda, Pío XII 36 31008 Pamplona SpainJorge Rioja, Universidad de Navarra Urology Department, Clínica Universitaria Avda, Pío XII 36 31008 Pamplona SpainIván Peñuelas, Universidad de Navarra Nuclear Medicine Departm... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2504314 Fri, 19 Jun 2009 06:45:01 +0100 2504314 Intravital Imaging of Tumor Apoptosis with FRET Probes During Tumor Therapy http://www.medworm.com/index.php?rid=2504313&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F34vx79r77rm4v117%2F Conclusions  FRET could be used effectively to monitor activation of caspase-3 in living organism. This method could be used to provide rapid assessment of apoptosis induced by anti-tumor therapies for improvement of treatment efficacy. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0235-yAuthors Feifan Zhou, South China Normal University MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science Guangzhou 510631 ChinaDa Xing, South China Normal University MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science Guangzhou 510631 ChinaShengnan Wu, South China Normal University MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science Guangzhou 510631 ChinaWei R. Chen, South China Normal... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2504313 Fri, 19 Jun 2009 06:45:01 +0100 2504313 Comparison of [18F]-Tracers in Various Experimental Tumor Models by PET Imaging and Identification of an Early Response Biomarker for the Novel Microtubule Stabilizer Patupilone http://www.medworm.com/index.php?rid=2504315&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw8337461037h0373%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s11307-009-0246-8Authors T. Ebenhan, Novartis Institute of Biomedical Research Global Imaging Group 4002 Basel SwitzerlandM. Honer, Eidgenoessische Technische Hochschule (ETH) Zurich Animal Imaging Center-PET, Center for Radiopharmaceutical Science Wolfgang-Pauli-Strasse 10 8093 Zurich SwitzerlandS. M. Ametamey, Eidgenoessische Technische Hochschule (ETH) Zurich Animal Imaging Center-PET, Center for Radiopharmaceutical Science Wolfgang-Pauli-Strasse 10 8093 Zurich SwitzerlandP. A. Schubiger, Eidgenoessische Technische Hochschule (ETH) Zurich Animal Imaging Center-PET, Center for Radiopharmaceutical Science Wolfgang-Pauli-Strasse 10 8093 Zurich SwitzerlandM. Becquet, Novartis Institute of Biomedical Research Oncology Research 4002 ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2504315 Thu, 18 Jun 2009 15:54:11 +0100 2504315 Feasibility of Whole-Body Functional Mouse Imaging Using Helical Pinhole SPECT http://www.medworm.com/index.php?rid=2504316&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk60q339184530m05%2F Conclusions  Helical paths can provide complete sampling data and large effective FOV, yielding 3D full-body in vivo biodistributions while still maintaining a small distance from the aperture to the object for good sensitivity and resolution. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0234-zAuthors Scott D. Metzler, University of Pennsylvania Department of Radiology 3400 Spruce St. Philadelphia PA 19104 USASreekanth Vemulapalli, Duke University Medical Center School of Medicine Durham NC 27710 USARonald J. Jaszczak, Duke University Medical Center Department of Radiology DUMC-3949 Durham NC 27710 USAGamal Akabani, Duke University Medical Center Department of Radiology DUMC-3949 Durham NC 27710 USABennett B. Chin, Duke University Medical C... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2504316 Fri, 12 Jun 2009 11:24:50 +0100 2504316 Potential of Dual Time Point FDG-PET Imaging in Differentiating Malignant from Benign Pleural Disease http://www.medworm.com/index.php?rid=2439896&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwp432267541n61lr%2F Conclusions  There is an increasing uptake of 18F-FDG over time in pleural malignancies, whereas the uptake in benign pleural disease generally stays stable or decreases over time. Therefore, dual time point imaging appears to be an effective approach in differentiating benign from malignant pleural disease, which increases the sensitivity and is also helpful in guiding the biopsy site for a successful diagnosis. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0212-5Authors Ayse Mavi, Hospital of the University of Pennsylvania Division of Nuclear Medicine 3400 Spruce Street, 110 Donner Bldg. Philadelphia PA 19104 USASandip Basu, Hospital of the University of Pennsylvania Division of Nuclear Medicine 3400 Spruce Street, 110 Donner Bldg. Phila... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2439896 Wed, 27 May 2009 05:48:44 +0100 2439896 Comparison of [18F]-Tracers in Various Experimental Tumor Models by PET Imaging and Identification of an Early Response Biomarker for the Novel Microtubule Stabilizer Patupilone http://www.medworm.com/index.php?rid=2432180&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg34626j40p607j05%2F Conclusion  [18F]FLT PET of experimental tumors is a viable complement to [18F]FDG for preclinical drug development. [18F]FLT may be an excellent biomarker for patupilone-induced apoptosis. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0216-1Authors T. Ebenhan, Novartis Institute of Biomedical Research Global Imaging Group 4002 Basel SwitzerlandM. Honer, Eidgenoessische Technische Hochschule (ETH) Zurich Animal Imaging Center-PET, Center for Radiopharmaceutical Science Wolfgang-Pauli-Strasse 10 CH-8093 Zurich SwitzerlandS.M. Ametamey, Eidgenoessische Technische Hochschule (ETH) Zurich Animal Imaging Center-PET, Center for Radiopharmaceutical Science Wolfgang-Pauli-Strasse 10 CH-8093 Zurich SwitzerlandP.A. Schubiger, Eidgenoessische Technisch... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2432180 Fri, 22 May 2009 05:53:21 +0100 2432180 Death and Proliferation Time Course of Stem Cells Transplanted in the Myocardium http://www.medworm.com/index.php?rid=2432184&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F93547544u170138n%2F Conclusions  The time course of transplanted stem cells surviving in the heart reveals a process of substantial cell loss within 24 h of injection and subsequent recovery of cell number through proliferation. Such proliferation can be noninvasively monitored by reporter gene imaging. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0222-3Authors Hui Qiao, University of Pennsylvania Department of Radiology Philadelphia PA 19104 USASuleman Surti, University of Pennsylvania Department of Radiology Philadelphia PA 19104 USASeok Rye Choi, University of Pennsylvania Department of Radiology Philadelphia PA 19104 USAKarthik Raju, University of Pennsylvania Department of Radiology Philadelphia PA 19104 USAHualei Zhang, University of Pennsylvania ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2432184 Thu, 21 May 2009 06:19:40 +0100 2432184 Initial Experience with the Radiotracer Anti-1-amino-3-[18F]Fluorocyclobutane-1-Carboxylic Acid (Anti-[18F]FACBC) with PET in Renal Carcinoma http://www.medworm.com/index.php?rid=2422813&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F158w42537q166473%2F Conclusions  In this small patient sample, relative amino acid transport compared with renal cortex is elevated in renal papillary cell carcinoma but not in clear cell carcinoma. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0220-5Authors David M. Schuster, Emory University Department of Radiology, Division of Nuclear Medicine Atlanta GA USAJonathon A. Nye, Emory University Department of Radiology, Division of Nuclear Medicine Atlanta GA USAPeter T. Nieh, Emory University Department of Urology Atlanta GA USAJohn R. Votaw, Emory University Department of Radiology, Division of Nuclear Medicine Atlanta GA USARaghuveer K. Halkar, Emory University Department of Radiology, Division of Nuclear Medicine Atlanta GA USAMuta M. Issa, Emory University ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2422813 Sat, 16 May 2009 05:56:41 +0100 2422813 A Convenient Thiazole Orange Fluorescence Assay for the Evaluation of DNA Duplex Hybridization Stability http://www.medworm.com/index.php?rid=2422814&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft467467473175280%2F Conclusions  When study duplexes shown to be stable in serum were incubated with their target cells, the assay successfully detected evidence of dissociation, most likely by an antisense mechanism. Thus, a TO fluorescence assay has been developed that is capable of detecting the dissociation of DNA duplexes. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0221-4Authors Minmin Liang, University of Massachusetts Medical School Department of Radiology Worcester MA 01655 USAXinrong Liu, University of Massachusetts Medical School Department of Radiology Worcester MA 01655 USAKayoko Nakamura, Keio University School of Medicine Department of Radiology Tokyo JapanXiangji Chen, University of Massachusetts Medical School Department of Radiology Worces... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2422814 Fri, 15 May 2009 06:18:07 +0100 2422814 Imaging Correlates of Differential Expression of Indoleamine 2,3-Dioxygenase in Human Brain Tumors http://www.medworm.com/index.php?rid=2422817&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn10111w074488085%2F Conclusion  Low-grade tumors show widespread IDO expression, while IDO expression in high-grade brain tumors can be absent or largely confined to endothelial cells. AMT PET can be useful to identify brain tumors with different profiles of IDO expression, thus providing a useful imaging marker for emerging treatments targeting tumor IDO activity. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0225-0Authors Carlos E. A. Batista, Wayne State University Carman and Ann Adams Department of Pediatrics, School of Medicine Detroit MI USACsaba Juhász, Wayne State University Carman and Ann Adams Department of Pediatrics, School of Medicine Detroit MI USAOtto Muzik, Wayne State University Carman and Ann Adams Department of Pediatrics, School of Medici... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2422817 Tue, 12 May 2009 05:59:45 +0100 2422817 Early Assessment of Therapeutic Response using FDG PET in Small Cell Lung Cancer http://www.medworm.com/index.php?rid=2422816&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx0531n4223317r2l%2F Conclusions  FDG PET has the potential to identify the therapeutic response in patients with SCLC as early as after the first cycle of chemotherapy. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0227-yAuthors Y. Yamamoto, Kagawa University Department of Radiology, Faculty of Medicine Kita-gun Kagawa JapanR. Kameyama, Kagawa University Department of Radiology, Faculty of Medicine Kita-gun Kagawa JapanM. Murota, Kagawa University Department of Radiology, Faculty of Medicine Kita-gun Kagawa JapanS. Bandoh, Kagawa University Department of First Internal Medicine, Faculty of Medicine Kagawa JapanT. Ishii, Kagawa University Department of First Internal Medicine, Faculty of Medicine Kagawa JapanY. Nishiyama, Kagawa University Department of Radiolo... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2422816 Tue, 12 May 2009 05:59:45 +0100 2422816 Simulations of Virtual PET/CT 3-D Bronchoscopy Imaging Using a Physical Porcine Lung–Heart Phantom http://www.medworm.com/index.php?rid=2422815&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7l7771236187254q%2F Conclusion  We have demonstrated a phantom model for studies of PET/CT 3-D virtual fly-through bronchoscopy and have applied this model for understanding the effect of PET thresholding on the visualization and detection of lesions. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0201-8Authors David Yerushalmi, Stanford University Department of Bioengineering The James H. Clark Center, 318 Campus Drive, E150 Stanford CA 94305 USARakesh Mullick, John F. Welch Technology Center, GE Global Research Imaging Technologies Lab Bangalore IndiaAndrew Quon, Stanford University Department of Radiology Stanford CA USARebecca Fahrig, Stanford University Department of Radiology Stanford CA USANorbert J. Pelc, Stanford University Department of Bioengineering... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2422815 Tue, 12 May 2009 05:59:45 +0100 2422815 Imaging Uterine Cervical Cancer with FDG-PET/CT: Direct Comparison with PET http://www.medworm.com/index.php?rid=2422818&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fen507703110u8k27%2F Conclusion  PET/CT was demonstrated to be useful in the definite localization and characterization of foci of increased FDG uptake, which provided its higher diagnostic accuracy than PET alone. PET/CT appears preferable to PET in the evaluation of cervical cancer, although additional study is needed. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-008-0180-1Authors Mitsuaki Tatsumi, Johns Hopkins Medical Institutions Division of Nuclear Medicine, Department of Radiology 601 North Caroline Street, Room 3223A Baltimore MD 21287-0817 USAChristian Cohade, Johns Hopkins Medical Institutions Division of Nuclear Medicine, Department of Radiology 601 North Caroline Street, Room 3223A Baltimore MD 21287-0817 USARobert E. Bristow, Johns Hopkins Medical Insti... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2422818 Tue, 12 May 2009 05:59:44 +0100 2422818 64Cu-Labeled PEGylated Polyethylenimine for Cell Trafficking and Tumor Imaging http://www.medworm.com/index.php?rid=2413426&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx367812527460711%2F Conclusion   64Cu-labeled polyethylenimine can be used for both cell trafficking and tumor imaging. PEGylation reduces the toxicity of 64Cu-PEI and improves the tumor imaging ability. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0228-xAuthors Zi-Bo Li, Stanford University School of Medicine The Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program Stanford CA USAKai Chen, Stanford University School of Medicine The Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program Stanford CA USAZhanhong Wu, Stanford University School of Medicine The Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program Stanford CA USAHui Wang, Stanford University Schoo... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2413426 Sat, 09 May 2009 05:58:33 +0100 2413426 Impact of Nonhybrid 99mTc-MDP-SPECT/CT Image Fusion in Diagnostic and Treatment of Oromaxillofacial Malignancies http://www.medworm.com/index.php?rid=2413429&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm4620mx232124630%2F Conclusion  Manual image fusion of CT and SPECT does not improve identification of bone infiltration compared to simultaneous evaluation. Though particularly in complex anatomical regions, a fixed preoperative diagnostic algorithm in image registration lead to a more precise evaluation and treatment of head and neck malignancies. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0231-2Authors Denys John Loeffelbein, Technische Universität München Department of Oral and Maxillofacial Surgery Ismaninger Str.22 81675 München GermanyEckhart Mielke, Ruhr-University Bochum Department of Radiology and Nuclear Medicine Bochum GermanyAndreas Konrad Buck, Technische Universität München Department of Nuclear Medicine München GermanyMarco Rainer Kes... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2413429 Sat, 09 May 2009 05:58:32 +0100 2413429 Correlating Metabolic Activity with Cellular Proliferation in Follicular Lymphomas http://www.medworm.com/index.php?rid=2413428&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm54tk70t53wn027r%2F Conclusion  The increasing trend of metabolic activity across follicular lymphoma grades correlates with cellular proliferation. The metabolic information from positron emission tomography–computed tomography may offer another useful parameter in the management of follicular lymphomas. Content Type Journal ArticleCategory Rapid CommunicationDOI 10.1007/s11307-009-0226-zAuthors Bingfeng Tang, William Beaumont Hospital Positron Diagnostic Center and Medical Cyclotron, Department of Nuclear Medicine Royal Oak MI USAJozef Malysz, William Beaumont Hospital Department of Pathology Royal Oak MI USAVonda Douglas-Nikitin, William Beaumont Hospital Department of Pathology Royal Oak MI USARichard Zekman, William Beaumont Hospital Department of Medical Oncology Royal Oak MI USAR... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2413428 Sat, 09 May 2009 05:58:32 +0100 2413428 PET/CT in the Evaluation of Inflammatory Bowel Disease: Studies in Patients Before and After Treatment http://www.medworm.com/index.php?rid=2413427&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fepg724815u11k656%2F Conclusion  Appropriate FDG-PET determination decreases with successful treatment of inflammation in active IBD and correlates with symptom improvement. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0232-1Authors Bret J. Spier, University of Wisconsin Hospital and Clinics in Madison Department of Gastroenterology and Hepatology Madison WI USAScott B. Perlman, University of Wisconsin Hospital and Clinics in Madison Department of Radiology Madison WI USAChristine J. Jaskowiak, University of Wisconsin Hospital and Clinics in Madison Department of Radiology Madison WI USAMark Reichelderfer, University of Wisconsin Hospital and Clinics in Madison Department of Gastroenterology and Hepatology Madison WI USA Journal Molecular Imaging and Bi... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2413427 Sat, 09 May 2009 05:58:32 +0100 2413427 Targeting Gelatinases with a Near-Infrared Fluorescent Cyclic His-Try-Gly-Phe Peptide http://www.medworm.com/index.php?rid=2402593&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu95113015047590p%2F Conclusions  Cy5.5–C6 may be a useful agent for molecular imaging of gelatinases. The approach of producing stable cyclic peptides through side chain amide linkage should be applicable to other peptide-based imaging agents. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0219-yAuthors Wei Wang, The University of Texas M. D. Anderson Cancer Center Department of Experimental Diagnostic Imaging—Unit 59, 1515 Holcombe Boulevard Houston TX 77030 USARuping Shao, The University of Texas M. D. Anderson Cancer Center Department of Experimental Diagnostic Imaging—Unit 59, 1515 Holcombe Boulevard Houston TX 77030 USAQingping Wu, The University of Texas M. D. Anderson Cancer Center Department of Experimental Diagnostic Imaging—Unit 59, 1515 Holco... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2402593 Fri, 08 May 2009 06:02:51 +0100 2402593 In Vivo Carbon-13 Dynamic MRS and MRSI of Normal and Fasted Rat Liver with Hyperpolarized 13C-Pyruvate http://www.medworm.com/index.php?rid=2402594&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh0218trv133j65t1%2F Conclusions  This study presents the initial demonstration of characterizing metabolic state differences in the liver with hyperpolarized 13C spectroscopy and shows the ability to detect physiological perturbations in alanine aminotransferase activity, which is an encouraging result for future liver disease investigations with hyperpolarized magnetic resonance technology. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0218-zAuthors Simon Hu, University of California, San Francisco Department of Radiology and Biomedical Imaging Box 2512 1700 4th St. QB3 Building, Suite 102 San Francisco CA 94158-2512 USAAlbert P. Chen, GE Healthcare Menlo Park CA USAMatthew L. Zierhut, University of California, San Francisco Department of Radiology and Biome... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2402594 Fri, 08 May 2009 05:57:10 +0100 2402594 PET/CT in Cancer: Moderate Sample Sizes may Suffice to Justify Replacement of a Regional Gold Standard http://www.medworm.com/index.php?rid=2402595&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn4200791u314tr27%2F Conclusions  If PET/CT provides an accuracy benefit in adjacent regions, then sample sizes can be reduced and the conduct of trials accelerated, leading to earlier decisions on the use of PET/CT while exposing fewer patients and reducing overall costs. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0224-1Authors Oke Gerke, Odense University Hospital Department of Nuclear Medicine Odense C DenmarkMads Hvid Poulsen, Odense University Hospital Department of Urology Odense C DenmarkKirsten Bouchelouche, Odense University Hospital Department of Nuclear Medicine Odense C DenmarkPoul Flemming Høilund-Carlsen, Odense University Hospital Department of Nuclear Medicine Odense C DenmarkWerner Vach, University of Southern Denmark Department of Statistics ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2402595 Fri, 08 May 2009 05:54:14 +0100 2402595 FDG-Accumulating Atherosclerotic Plaques Identified with 18F-FDG-PET/CT in 141 Patients http://www.medworm.com/index.php?rid=2402596&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw22v4k2t68n72488%2F Conclusions  The observed association between the numbers of cardiovascular risk factors and the numbers of FDG-accumulating plaques as well as calcified plaques further supports the validity and value of FDG-PET/CT in the non-invasive identification and characterization of atherosclerotic disease. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0223-2Authors Johan A. Wassélius, The Karolinska Institute Department of Molecular Medicine and Surgery Stockholm SwedenStig A. Larsson, The Karolinska University Hospital Department of Nuclear Medicine Stockholm SwedenHans Jacobsson, The Karolinska Institute Department of Molecular Medicine and Surgery Stockholm Sweden Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2402596 Fri, 08 May 2009 05:54:13 +0100 2402596 Visualization of Somatostatin Receptors in Prostate Cancer and its Bone Metastases with Ga-68–DOTATOC PET/CT http://www.medworm.com/index.php?rid=2402597&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3t81pj228010u062%2F Conclusions  In prostate cancer and its bone metastases, DOTATOC-affine somatostatin receptors (subtype 2 and 5) can be visualized with Ga-68–DOTATOC PET/CT. But their expression is so weak that other conjugates should be tested for receptor-mediated therapies which are better at addressing the prostate cancer-specific somatostatin receptor subtypes 1 and 4—or even other receptors. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0230-3Authors Wolfgang Luboldt, University Hospital Dresden Clinic and Policlinic of Nuclear Medicine Dresden GermanyKlaus Zöphel, University Hospital Dresden Clinic and Policlinic of Nuclear Medicine Dresden GermanyGerd Wunderlich, University Hospital Dresden Clinic and Policlinic of Nuclear Medicine Dresden Ge... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2402597 Thu, 07 May 2009 05:57:35 +0100 2402597 Impact of FDG-PET on Prediction of Clinical Outcome after Concurrent Chemoradiotherapy in Hypopharyngeal Carcinoma http://www.medworm.com/index.php?rid=2402598&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj144r04063233298%2F Conclusions  Posttreatment FDG uptake represents an independent prognostic factor for hypopharyngeal carcinoma treated by chemoradiotherapy. Patients with a high posttreatment FDG uptake may benefit from adjuvant chemotherapy. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0229-9Authors Hidenori Inohara, Osaka University School of Medicine Department of Otolaryngology 2-2 Yamadaoka, Suita Osaka 565-0871 JapanKeisuke Enomoto, Osaka University School of Medicine Department of Otolaryngology 2-2 Yamadaoka, Suita Osaka 565-0871 JapanYoichiro Tomiyama, Osaka University School of Medicine Department of Otolaryngology 2-2 Yamadaoka, Suita Osaka 565-0871 JapanIchiro Higuchi, Osaka University School of Medicine Department of Nuclear Medicine and Trac... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2402598 Thu, 07 May 2009 05:57:33 +0100 2402598 Consensus Science and the Peer Review http://www.medworm.com/index.php?rid=2386561&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2h05m072660674l2%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s11307-009-0233-0Authors Jorge R. Barrio, David Geffen UCLA School of Medicine Department of Molecular and Medical Pharmacology Los Angeles CA USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2386561 Tue, 28 Apr 2009 16:35:37 +0100 2386561 Assessment of Airway Distribution of Transnasal Solutions in Mice by PET/CT Imaging http://www.medworm.com/index.php?rid=2340360&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx786666553046421%2F Conclusions  In this first report on quantitative imaging by PET and CT in small animals, we confirmed the suitability of the transnasal route with an instilled volume of 30 μl delivering fluids into the lower airways, although only about 40% of the dose reaches the lungs. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0199-yAuthors ML Soto-Montenegro, Hospital General Universitario Gregorio Marañón Unidad de Medicina y Cirugía Experimental Dr. Esquerdo, 46 28007 Madrid SpainL Conejero, Hospital General Universitario Gregorio Marañón Servicio de Alergia Madrid SpainJJ Vaquero, Hospital General Universitario Gregorio Marañón Unidad de Medicina y Cirugía Experimental Dr. Esquerdo, 46 28007 Madrid SpainML Baeza, Hospital General ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2340360 Thu, 02 Apr 2009 05:55:32 +0100 2340360 Evaluation of Tracer Kinetic Models for Analysis of [18F]FDDNP Studies http://www.medworm.com/index.php?rid=2340361&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F669n870k6r020740%2F Conclusions  SRTM is the method of choice for quantitative analysis of [18F]FDDNP even if it is unclear whether labeled metabolites enter the brain. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0208-1Authors Maqsood Yaqub, VU University Medical Centre Department of Nuclear Medicine & PET Research P.O. Box 7057 1007 MB Amsterdam The NetherlandsRonald Boellaard, VU University Medical Centre Department of Nuclear Medicine & PET Research P.O. Box 7057 1007 MB Amsterdam The NetherlandsBart N. M. van Berckel, VU University Medical Centre Department of Nuclear Medicine & PET Research P.O. Box 7057 1007 MB Amsterdam The NetherlandsNelleke Tolboom, VU University Medical Centre Department of Neurology & Alzheimer Centre P.O. Box 7057 1007 MB Amsterda... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2340361 Thu, 02 Apr 2009 05:55:21 +0100 2340361 Clinical Value and Limitations of [11C]-Methionine PET for Detection and Localization of Suspected Parathyroid Adenomas http://www.medworm.com/index.php?rid=2340362&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmnn4315331369027%2F Conclusions  In patients with initial diagnosis of hyperparathyroidism and no prior thyroidectomy, the sensitivity of MET-PET for detection and localization of parathyroid adenomas is markedly lower compared to previous reports. While performance was better in sHPT, we believe that MET-PET cannot be recommended for pHPT localization in this clinically relevant subcollective. The clinical value of MET/PET in patients with hyperparathyroidism should be further investigated in a prospective study utilizing anatometabolic imaging with a PET/CT device. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0205-4Authors Ken Herrmann, Hokkaido University Department of Nuclear Medicine, Graduate School of Medicine Kita 15, Nishi 7, Kita-ku Sapporo 060-8... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2340362 Thu, 02 Apr 2009 05:55:20 +0100 2340362 First Evaluation of [11C]R116301 as an In Vivo Tracer of NK1 Receptors in Man http://www.medworm.com/index.php?rid=2340363&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcg32113217v28611%2F Conclusion  These preliminary results indicate that [11C]R116301 has potential as a radioligand for in vivo assessment of NK1 receptors in the human brain. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0204-5Authors Saskia P. A. Wolfensberger, VU University Medical Centre Department of Nuclear Medicine & PET Research P.O. BOX 7057 1007 MB Amsterdam The NetherlandsBart N. M. van Berckel, VU University Medical Centre Department of Nuclear Medicine & PET Research P.O. BOX 7057 1007 MB Amsterdam The NetherlandsAnu J. Airaksinen, VU University Medical Centre Department of Nuclear Medicine & PET Research P.O. BOX 7057 1007 MB Amsterdam The NetherlandsKaoru Maruyama, VU University Medical Centre Department of Nuclear Medicine & PET Research P.O. BOX 7... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2340363 Tue, 31 Mar 2009 05:49:35 +0100 2340363 Early 2′-Deoxy-2′-[18F]Fluoro-d -Glucose PET Metabolic Response after Corticosteroid Therapy to Differentiate Cancer from Sarcoidosis and Sarcoid-like Lesions http://www.medworm.com/index.php?rid=2340364&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb2800xq6426u1q68%2F Conclusion  Early metabolic response to systemic corticosteroid treatment may be used as a tool in the establishment of final diagnosis when sarcoidosis is suspected in a cancer patient and could be capable of differentiating cancer from sarcoidosis in the case of coexisting diseases. Content Type Journal ArticleCategory Rapid CommunicationDOI 10.1007/s11307-008-0191-yAuthors Nicolas Aide, François Baclesse Comprehensive Cancer Centre Nuclear Medicine Department Caen FranceDjelila Allouache, François Baclesse Comprehensive Cancer Centre Medical Oncology Caen FranceYann Ollivier, Caen University Hospital Internal Medicine Caen FranceSixtine de Raucourt, François Baclesse Comprehensive Cancer Centre Medical Oncology Caen FranceOdile Switsers, François Baclesse Compre... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2340364 Tue, 31 Mar 2009 05:49:34 +0100 2340364 [11C]-DPA-713 and [18F]-DPA-714 as New PET Tracers for TSPO: A Comparison with [11C]-( R )-PK11195 in a Rat Model of Herpes Encephalitis http://www.medworm.com/index.php?rid=2340365&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw543mh8651v717lv%2F Conclusions  [11C]-DPA-713 may be more suitable for visualizing mild inflammation than [11C]-(R)-PK11195. In addition, the fact that [18F]-DPA-714 is an agonist PET tracer opens new possibilities to evaluate different aspects of neuroinflammation. Therefore, both tracers warrant further investigation in animal models and in a clinical setting. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0211-6Authors Janine Doorduin, University Medical Center Groningen, University of Groningen Department of Nuclear Medicine and Molecular Imaging P.O. Box 30.001 9700 RB Groningen The NetherlandsHans C. Klein, University Medical Center Groningen, University of Groningen Department of Nuclear Medicine and Molecular Imaging P.O. Box 30.001 9700 RB Groningen T... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2340365 Sat, 28 Mar 2009 09:06:01 +0100 2340365 Effective Inhibition of Xenografts of Hepatocellular Carcinoma (HepG2) by Rapamycin and Bevacizumab in an Intrahepatic Model http://www.medworm.com/index.php?rid=2340366&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl2613l5n264551m2%2F Conclusions  Our results, supported by micro-PET/CT, suggest that RAPA/BEV represents a potential novel antiangiogenic therapy for the treatment of HCC. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0213-4Authors Lai-Chun Ong, Singapore General Hospital Outram Road Singapore 169608 SingaporeIn-Chin Song, Singapore General Hospital Outram Road Singapore 169608 SingaporeYi Jin, Singapore General Hospital Outram Road Singapore 169608 SingaporeIrene H. C. Kee, Singapore General Hospital Outram Road Singapore 169608 SingaporeEeyan Siew, Singapore General Hospital Outram Road Singapore 169608 SingaporeSidney Yu, Singapore General Hospital Outram Road Singapore 169608 SingaporeChoon-Hua Thng, National Cancer Centre 11 Hospital Drive Singapore 1696... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2340366 Sat, 28 Mar 2009 09:05:59 +0100 2340366 NEC Density and Liver ROI S/N Ratio for Image Quality Control of Whole-Body FDG-PET Scans: Comparison with Visual Assessment http://www.medworm.com/index.php?rid=2340368&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fkg4823q731228vh1%2F Conclusions  NEC density, representing count statistics per body volume, reflects the visual image quality assessment and may be utilized for quality control of whole-body FDG-PET images together with the liver ROI S/N ratio. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0214-3Authors Tetsuro Mizuta, Shimadzu Corporation Medical Systems Division Kyoto JapanMichio Senda, Institute of Biomedical Research and Innovation Department of Image-Based Medicine Kobe JapanTerue Okamura, Saiseikai Nakatsu Hospital Department of PET center Osaka JapanKeishi Kitamura, Shimadzu Corporation Medical Systems Division Kyoto JapanYuichi Inaoka, Shimadzu Corporation Medical Systems Division Kyoto JapanMunehiro Takahashi, Shimadzu Corporation Medical Systems Div... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2340368 Sat, 28 Mar 2009 09:05:58 +0100 2340368 Prognostic Value of 18F-FDG PET/CT in Patients with Malignant Pleural Mesothelioma http://www.medworm.com/index.php?rid=2340367&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu04v41343x265247%2F Conclusions  Detection of extrathoracic metastases on FDG-PET/CT and nonepithelioid histopathology are poor prognostic indicators in patients with MM. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0203-6Authors S. T. Lee, Austin Health Centre for PET Heidelberg Victoria 3084 AustraliaM. Ghanem, Austin Health Centre for PET Heidelberg Victoria 3084 AustraliaR. A. Herbertson, Austin Health Ludwig Institute for Cancer Research, Melbourne Centre for Clinical Sciences Heidelberg Victoria AustraliaS. U. Berlangieri, Austin Health Centre for PET Heidelberg Victoria 3084 AustraliaA. J. Byrne, Austin Health Centre for PET Heidelberg Victoria 3084 AustraliaK. Tabone, Austin Health Centre for PET Heidelberg Victoria 3084 AustraliaP. Mitchell, Universi... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2340367 Sat, 28 Mar 2009 09:05:58 +0100 2340367 The Use of F-18 Choline PET in the Assessment of Bone Metastases in Prostate Cancer: Correlation with Morphological Changes on CT http://www.medworm.com/index.php?rid=2295923&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F08728204p611x821%2F Conclusion  FCH-PET/CT showed promising results for the early detection of bone metastases in prostate cancer patients. We have found that a HU level of above 825 is associated with an absence of FCH uptake. Almost all of the FCH-negative sclerotic lesions were detected in patients who were under hormone therapy, which raises the possibility that these lesions might no longer be viable. However, clarification and the prognostic value of such lesions require further research. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0217-0Authors Mohsen Beheshti, St. Vincent’s Hospital Nuclear Medicine & Endocrinology, PET/CT Center Linz Linz AustriaReza Vali, St. Vincent’s Hospital Nuclear Medicine & Endocrinology, PET/CT Center Linz Linz Austria... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2295923 Fri, 27 Mar 2009 06:56:19 +0100 2295923 Replacing 99mTc with 111In Improves MORF/cMORF Pretargeting by Reducing Intestinal Accumulation http://www.medworm.com/index.php?rid=2295926&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp518w28q151u26q3%2F Conclusion  In applications of MORF/cMORF pretargeting intended to image organs deep within the abdomen such as the pancreas, radiolabeling with 111In may be superior to 99mTc. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0209-0Authors Guozheng Liu, University of Massachusetts Medical School Division of Nuclear Medicine, Department of Radiology 55 Lake Ave North Worcester MA 01655-0243 USADengfeng Cheng, University of Massachusetts Medical School Division of Nuclear Medicine, Department of Radiology 55 Lake Ave North Worcester MA 01655-0243 USAShuping Dou, University of Massachusetts Medical School Division of Nuclear Medicine, Department of Radiology 55 Lake Ave North Worcester MA 01655-0243 USAXiangji Chen, University of Massachusetts Medic... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2295926 Fri, 27 Mar 2009 06:56:18 +0100 2295926 A Randomised Controlled Trial Assessing the Effect of Oral Diazepam on 18F-FDG Uptake in the Neck and Upper Chest Region http://www.medworm.com/index.php?rid=2295928&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F71711t3773521375%2F Conclusion  No beneficial effect of administration of diazepam could be established. Pre-medication with benzodiazepines to diminish physiological uptake of 18F-FDG in the neck and upper chest region is not indicated. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0207-2Authors Marieke G.G. Sturkenboom, VU University Medical Center Department of Pharmacy Amsterdam The NetherlandsOtto S. Hoekstra, VU University Medical Center Department of Nuclear Medicine and PET Research Amsterdam The NetherlandsErnst J. Postema, Catharina Hospital Department of Nuclear Medicine Eindhoven The NetherlandsJosée M. Zijlstra, VU University Medical Center Department of Haematology Amsterdam The NetherlandsJohannes Berkhof, VU University Medical Center Departmen... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2295928 Fri, 27 Mar 2009 06:56:17 +0100 2295928 99mTc-Tetrofosmin SPECT for Glioma Evaluation http://www.medworm.com/index.php?rid=2295932&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F61x54p433275030q%2F Content Type Journal ArticleCategory CommentaryDOI 10.1007/s11307-009-0202-7Authors George A. Alexiou, University of Ioannina School of Medicine Department of Neurosurgery P. O. Box 103 Neohoropoulo Ioannina 455 00 GreeceSpyridon Tsiouris, University of Ioannina School of Medicine Department of Nuclear Medicine Ioannina GreeceAthanasios P. Kyritsis, University of Ioannina School of Medicine Department of Neurology Ioannina GreeceSpyridon Voulgaris, University of Ioannina School of Medicine Department of Neurosurgery P. O. Box 103 Neohoropoulo Ioannina 455 00 GreeceKonstantinos S. Polyzoidis, University of Ioannina School of Medicine Department of Neurosurgery P. O. Box 103 Neohoropoulo Ioannina 455 00 GreeceAndreas D. Fotopoulos, University of Ioannina School of Medicine Department of ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2295932 Fri, 27 Mar 2009 06:56:16 +0100 2295932 Time Sensitivity: A Parameter Reflecting Tumor Metabolic Kinetics by Variable Dual-Time F-18 FDG PET Imaging http://www.medworm.com/index.php?rid=2295934&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwu6k35wg4tq47n4g%2F Conclusions  The time sensitivity factor reflects another kinetic parameter of tumor metabolism besides SUV when using variable dual-time FDG PET. It offers another useful diagnostic tool in optimizing choices of dual-time protocols for oncologic PET–CT and in reducing SUV variations due to time interval differences with corrections using S. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0206-3Authors Ching-yee Oliver Wong, William Beaumont Hospital Department of Nuclear Medicine 3601 W. Thirteen Mile Road Royal Oak MI 48073-6769 USADaniel Noujaim, William Beaumont Hospital Department of Nuclear Medicine 3601 W. Thirteen Mile Road Royal Oak MI 48073-6769 USAHungsen F. Fu, Tri-Service General Hospital Nuclear Medicine Taipei TaiwanWen-shen... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2295934 Fri, 27 Mar 2009 06:56:15 +0100 2295934 Comparison of CT, PET, and PET/CT for Staging of Patients with Indolent Non-Hodgkin’s Lymphoma http://www.medworm.com/index.php?rid=2295939&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F51517371322th5n3%2F Conclusions  PET/CT provides significantly more accurate information compared to PET and CT for the staging and re-staging of patients with indolent lymphoma. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0200-9Authors Barbara J. Fueger, UCLA Department of Molecular and Medical Pharmacology, David Geffen School of Medicine Los Angeles CA 90095 USAKristen Yeom, UCLA Department of Radiology, David Geffen School of Medicine Los Angeles CA 90095 USAJohannes Czernin, UCLA Department of Molecular and Medical Pharmacology, David Geffen School of Medicine Los Angeles CA 90095 USAJames W. Sayre, UCLA Department of Radiology, David Geffen School of Medicine Los Angeles CA 90095 USAMichael E. Phelps, UCLA Department of Molecular and Medical Pharmacolo... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2295939 Fri, 27 Mar 2009 06:56:14 +0100 2295939 NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy of 3′-Deoxy-3′-[18F]fluorothymidine (FLT) as a Marker of Proliferation in Patients with Recurrent Gliomas: Preliminary Efficacy Studies http://www.medworm.com/index.php?rid=2295938&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd2n325746273n065%2F Conclusions   K FLT (flux) appears to distinguish recurrence from radionecrosis better than other parameters, FLT and FDG semiquantitative approaches, or visual analysis of images of either tracer. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0215-2Authors Alexander M. Spence, University of Washington Department of Neurology Mailstop 356465 1959 NE Pacific Street Seattle WA 98195 USAMark Muzi, University of Washington Department of Radiology Seattle WA USAJeanne M. Link, University of Washington Department of Radiology Seattle WA USAFinbarr O’Sullivan, University College Cork Department of Statistics Cork IrelandJanet F. Eary, University of Washington Department of Radiology Seattle WA USAJohn M. Hoffman, University of Utah Departments... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2295938 Fri, 27 Mar 2009 06:56:14 +0100 2295938 Positron Emission Tomography in Mesothelioma Patients http://www.medworm.com/index.php?rid=2295941&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx03x741j2u7823n3%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s11307-009-0210-7Authors Gaia Grassetto, ‘Santa Maria della Misericordia’ Hospital Department of Nuclear Medicine, PET Center Viale Tre Martiri 140 45100 Rovigo ItalyDomenico Rubello, ‘Santa Maria della Misericordia’ Hospital Department of Nuclear Medicine, PET Center Viale Tre Martiri 140 45100 Rovigo Italy Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2295941 Wed, 25 Mar 2009 06:54:23 +0100 2295941 Simultaneous [99mTc]TRODAT-1 and [123I]ADAM Brain SPECT in Nonhuman Primates http://www.medworm.com/index.php?rid=2204303&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb21mt231n84614g9%2F Conclusion  Simultaneous [123I]-ADAM and [99mTc]TRODAT-1 SPECT appears promising in nonhuman primates and may provide a suitable preclinical model with further clinical implications. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0197-0Authors Kuo-Hsing Ma, National Defense Medical Center Department of Biology and Anatomy Taipei TaiwanJong-Kang Lee, Chung-Shan Medical University Hospital Department of Nuclear Medicine Taichung TaiwanSan-Yuan Huang, Tri-Service General Hospital Department of Psychiatry Taipei TaiwanChin-Bin Yeh, Tri-Service General Hospital Department of Psychiatry Taipei TaiwanYi-Chun Shen, Buddhist Tzu Chi Dalin General Hospital Department of Medical Imaging Chiayi TaiwanLie-Hang Shen, Institute of Nuclear Energy Research T... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2204303 Thu, 19 Feb 2009 14:18:32 +0100 2204303 Limitations of Small Animal PET Imaging with [18F]FDDNP and FDG for Quantitative Studies in a Transgenic Mouse Model of Alzheimer’s Disease http://www.medworm.com/index.php?rid=2186846&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2500148t416k71j1%2F Conclusions  We could not detect regionally increased [18F]FDDNP binding and regionally decreased FDG binding in the brains of Tg2576 transgenic versus wild-type mice. However, small group differences in signal might have been masked by inter-animal variability. In addition, technical limitations of the applied method (partial volume effect, spatial resolution) for measurements in such small organs as mouse brain have to be taken into consideration. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-009-0198-zAuthors Claudia Kuntner, Austrian Research Centers GmbH—ARC Department of Radiopharmaceuticals & microPET Imaging 2444 Seibersdorf AustriaAdam L. Kesner, UCLA Department of Molecular and Medical Pharmacology, David Geffen School of Medicine Los... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2186846 Fri, 13 Feb 2009 07:53:52 +0100 2186846 In Vivo Dendritic Cell Tracking Using Fluorescence Lifetime Imaging and Near-Infrared-Emissive Polymersomes http://www.medworm.com/index.php?rid=2166854&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F75201l27188412lk%2F Conclusions  This work provides a tool to evaluate dendritic-cell-based immunotherapy and generates novel opportunities for in vivo fluorescence imaging. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0184-xAuthors Natalie A. Christian, University of Pennsylvania Department of Bioengineering, School of Engineering and Applied Science 210 S. 33rd Street Room 240 Skirkanich Hall Philadelphia PA 19104 USAFabian Benencia, University of Pennsylvania Center for Research on Ovarian Cancer Early Detection and Cure Philadelphia PA USAMichael C. Milone, University of Pennsylvania Department of Pathology and Laboratory Medicine Philadelphia PA USAGuizhi Li, University of Pennsylvania Department of Chemistry Philadelphia PA USAPaul R. Frail, University o... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2166854 Thu, 05 Feb 2009 06:58:18 +0100 2166854 Prognostic Value of FDG-PET in Patients with Oropharyngeal Carcinoma Treated with Concurrent Chemoradiotherapy http://www.medworm.com/index.php?rid=2097588&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff5u2628375311h24%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s11307-008-0196-6Authors Keisuke Enomoto, Osaka University School of Medicine Department of Otolaryngology 2-2, Yamadaoka Suita Osaka 565-0871 JapanHidenori Inohara, Osaka University School of Medicine Department of Otolaryngology 2-2, Yamadaoka Suita Osaka 565-0871 JapanIchiro Higuchi, Osaka University School of Medicine Department of Nuclear Medicine and Tracer Kinetics 2-2, Yamadaoka Suita Osaka 565-0871 JapanKenichiro Hamada, Osaka University School of Medicine Department of Nuclear Medicine and Tracer Kinetics 2-2, Yamadaoka Suita Osaka 565-0871 JapanYoichiro Tomiyama, Osaka University School of Medicine Department of Otolaryngology 2-2, Yamadaoka Suita Osaka 565-0871 JapanTakeshi Kubo, Osaka University School of Medicine Dep... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2097588 Sat, 10 Jan 2009 13:20:15 +0100 2097588 Dynamic Monitoring of Apoptosis in Chemotherapies with Multiple Fluorescence Reporters http://www.medworm.com/index.php?rid=2094447&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffk08n6h5180v46h5%2F Conclusions  The new approach successfully reveals the difference in temporal signaling apoptosis events between Taxol and cisplatin. It may help us come to a better understanding of the detailed mechanisms in chemotherapeutic-agents-induced apoptosis. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0195-7Authors Yunlong Li, South China Normal University MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science Guangzhou 510631 ChinaDa Xing, South China Normal University MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science Guangzhou 510631 ChinaQun Chen, South China Normal University MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science Guangzhou 510631 China Journal Mol... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2094447 Fri, 09 Jan 2009 11:56:36 +0100 2094447 Metabolic Changes in the Rodent Brain after Acute Administration of Salvinorin A http://www.medworm.com/index.php?rid=2094448&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7t126r25j70n18h1%2F Conclusions  We have provided the first extensive maps of cerebral metabolic activation due to the potent κ-opioid agonist, salvinorin A. A major finding from our small animal PET studies using FDG was that neural circuits affected by SA may not be limited to direct activation or inhibition of kappa-receptor-expressing cells. Instead, salvinorin A may trigger brain circuits that mediate the effects of the drug on cognition, mood, fear and anxiety, and motor output. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-008-0192-xAuthors Jacob M. Hooker, Brookhaven National Laboratory Medical Department Upton NY 11973 USAVinal Patel, Brookhaven National Laboratory Medical Department Upton NY 11973 USAShiva Kothari, Brookhaven National Laboratory Medical ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2094448 Fri, 09 Jan 2009 11:56:35 +0100 2094448 PET Imaging Studies in Rhesus Monkey with the Cannabinoid-1 (CB1) Receptor Ligand [11C]CB-119 http://www.medworm.com/index.php?rid=2094449&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F08483g5847027315%2F Conclusions  [11C]CB-119 is a suitable tracer for imaging central CB1 receptors. Content Type Journal ArticleCategory Rexearch ArticleDOI 10.1007/s11307-008-0194-8Authors Terence G. Hamill, Merck Research Laboratories, Imaging Research Department WP44C-2 West Point PA 19486 USALinus S. Lin, Merck Research Laboratories, Medicinal Chemistry Department Rahway NJ 07065 USAWilliam Hagmann, Merck Research Laboratories, Medicinal Chemistry Department Rahway NJ 07065 USAPing Liu, Merck Research Laboratories, Medicinal Chemistry Department Rahway NJ 07065 USAJames Jewell, Merck Research Laboratories, Medicinal Chemistry Department Rahway NJ 07065 USASandra Sanabria, Merck Research Laboratories, Imaging Research Department WP44C-2 West Point PA 19486 USAWaiSi Eng, Merck Research L... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2094449 Thu, 08 Jan 2009 10:35:31 +0100 2094449 A Molecular Imaging Paradigm to Rapidly Profile Response to Angiogenesis-directed Therapy in Small Animals http://www.medworm.com/index.php?rid=2094450&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff6673445x167p51v%2F Conclusions  Molecular imaging of VEGFR2 expression is a promising non-invasive biomarker for assessing angiogenesis and evaluating the efficacy of angiogenesis-directed therapies. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0193-9Authors John Virostko, Vanderbilt University Medical Center Vanderbilt University Institute of Imaging Science (VUIIS) Nashville TN 37232 USAJingping Xie, Vanderbilt University Medical Center Vanderbilt University Institute of Imaging Science (VUIIS) Nashville TN 37232 USADennis E. Hallahan, Vanderbilt University Medical Center Vanderbilt University Institute of Imaging Science (VUIIS) Nashville TN 37232 USACarlos L. Arteaga, Vanderbilt University School of Medicine Departments of Medicine and Cancer Biology; Br... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2094450 Thu, 08 Jan 2009 10:35:28 +0100 2094450 Time-Course of Contrast Enhancement in Spleen and Liver with Exia 160, Fenestra LC, and VC http://www.medworm.com/index.php?rid=2032466&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe42022u45280175k%2F Conclusions  Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0186-8Authors Inneke Willekens, Vrije Universiteit Brussel In vivo Cellular and Molecular Imaging—ICMI Brussels BelgiumTony Lahoutte, Vrije Universiteit Brussel In vivo Cellular and Molecular Imaging—ICMI Brussels BelgiumNico Buls, UZ Brussel Department of Radiology Brussels BelgiumChristian Vanhove, UZ Brussel Department of Nuclear Medicine Brussels BelgiumRudi Deklerck, Electronics and Informatics—ETRO–IRIS, Vrije Universiteit Brussel Brussels BelgiumAxel Bossuyt, Vrije Universiteit Brussel In vivo Cellular and Molecular Imaging—ICMI Brussels BelgiumJohan de Mey... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2032466 Wed, 10 Dec 2008 07:40:15 +0100 2032466 Toward Quantitative Small Animal Pinhole SPECT: Assessment of Quantitation Accuracy Prior to Image Compensations http://www.medworm.com/index.php?rid=2010597&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw35736whm2396518%2F Conclusions  We have systematically quantified the influence of several factors affecting the quantitation accuracy of small animal pinhole SPECT. In order to consistently achieve accurate quantitation within 5% of the truth, comprehensive image compensation methods are needed. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0181-0Authors Chia-Lin Chen, Chung Shan Medical University Department of Medical Imaging and Radiological Sciences Taichung 402 Taiwan Republic of ChinaYuchuan Wang, Johns Hopkins University School of Medicine Division of Medical Imaging Physics, The Russell H. Morgan Department of Radiology and Radiological Science Baltimore MD 21287 USAJason J. S. Lee, National Yang-Ming University Department of Biomedical Imaging & Ra... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2010597 Tue, 02 Dec 2008 07:36:13 +0100 2010597 Molecular Imaging of Phosphorylation Events for Drug Development http://www.medworm.com/index.php?rid=2010598&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd9183nx27h47k351%2F Conclusion  This generalizable approach for noninvasive monitoring of phosphorylation events will accelerate the discovery and validation of novel kinase inhibitors and modulators of phosphorylation events. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0187-7Authors C. T. Chan, Stanford University School of Medicine Department of Radiology Stanford CA 94305 USAR. Paulmurugan, Stanford University School of Medicine Department of Radiology Stanford CA 94305 USAR. E. Reeves, Stanford University School of Medicine Department of Radiology Stanford CA 94305 USAD. Solow-Cordero, Stanford University School of Medicine Department of Chemical Biology Stanford CA 94305 USAS. S. Gambhir, Stanford University School of Medicine Department of Radiology St... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=2010598 Tue, 02 Dec 2008 07:36:12 +0100 2010598 Pretreatment with Diphenoxylate Hydrochloride/Atropine Sulfate (Lomotil) does not Decrease Physiologic Bowel FDG Activity on PET/CT Scans of the Abdomen and Pelvis http://www.medworm.com/index.php?rid=1995726&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F055k23n121443l75%2F Conclusions  Pretreatment with Lomotil prior to PET/CT scanning confers no benefit toward the reduction of physiologic FDG uptake by the small bowel and colon. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0178-8Authors Robert Murphy, Mayo Clinic Department of Radiology 200 First Street SW Rochester MN 55905 USAKirk M. Doerger, Radiology Associates of Northern Kentucky 170 Barnwood Drive Edgewood KY 41017 USAMark A. Nathan, Mayo Clinic Department of Radiology 200 First Street SW Rochester MN 55905 USAVal J. Lowe, Mayo Clinic Department of Radiology 200 First Street SW Rochester MN 55905 USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1995726 Thu, 27 Nov 2008 09:39:40 +0100 1995726 Detection of Visual Activation in the Rat Brain Using 2-deoxy-2-[18F]fluoro-d -glucose and Statistical Parametric Mapping (SPM) http://www.medworm.com/index.php?rid=1995725&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg55515k74q32uj20%2F Conclusions  To our knowledge, this is the first report that uses FDG-PET and SPM analysis to show changes in rat brain glucose metabolism after a visual stimulus. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0179-7Authors M. L. Soto-Montenegro, Hospital General Universitario Gregorio Marañón Unidad de Medicina y Cirugia Experimental C/Dr. Esquerdo, 46 Madrid 28007 SpainJ. J. Vaquero, Hospital General Universitario Gregorio Marañón Unidad de Medicina y Cirugia Experimental C/Dr. Esquerdo, 46 Madrid 28007 SpainJ. Pascau, Hospital General Universitario Gregorio Marañón Unidad de Medicina y Cirugia Experimental C/Dr. Esquerdo, 46 Madrid 28007 SpainJ. D. Gispert, Institut d’Alta Tecnologia-PRBB. CRC Corporació Sanitària Dr, Aiguader,... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1995725 Thu, 27 Nov 2008 09:39:40 +0100 1995725 Noninvasive Visualization of microRNA by Bioluminescence Imaging http://www.medworm.com/index.php?rid=1995728&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ffp0770111371g35u%2F Content Type Journal ArticleCategory CommentaryDOI 10.1007/s11307-008-0190-zAuthors Gang Niu, Stanford University School of Medicine The Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program 1201 Welch Rd, P095 Stanford CA 94305-5484 USAXiaoyuan Chen, Stanford University School of Medicine The Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program 1201 Welch Rd, P095 Stanford CA 94305-5484 USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1995728 Thu, 27 Nov 2008 09:39:39 +0100 1995728 Increasing Uptake Time in FDG-PET: Standardized Uptake Values in Normal Tissues at 1 versus 3 h http://www.medworm.com/index.php?rid=1995727&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp75035q00060p452%2F Conclusions  On FDG imaging at 3 h compared to 1 h, significant changes were apparent, but the magnitude of changes was modest overall. Three-hour delayed imaging demonstrated significantly lower aortic blood pool and adipose tissue activity and significantly higher cerebellum, muscle, spleen, and bone marrow activity. Hepatic and lung activities were not significantly different. These results suggest that previously reported improvements in tumor image contrast with delayed imaging may be primarily due to cumulative FDG uptake within the tumor rather than reduction in normal background activity. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0177-9Authors Bennett B. Chin, Duke University Medical Center Department of Radiology, ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1995727 Thu, 27 Nov 2008 09:39:39 +0100 1995727 Detection of Homo- or Hetero-Association of Doks by Fluorescence Resonance Energy Transfer in Living Cells http://www.medworm.com/index.php?rid=1995730&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj3v69233q3323837%2F Conclusion  The mechanisms underlying Doks’ association may benefit the further understanding of the important role of Dok proteins in regulating signal transduction activated by tyrosine kinases. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0189-5Authors Feng Zhang, Second Military Medical University Department of Neurobiology, Institute of Neuroscience Shanghai 200433 ChinaGuo Fu, Second Military Medical University Department of Neurobiology, Institute of Neuroscience Shanghai 200433 ChinaChen Wang, Chinese Academy of Sciences State Key Laboratory of High Field Laser Physics, Shanghai Institute of Optics and Fine Mechanics Shanghai 201800 ChinaLi Cao, Second Military Medical University Department of Neurobiology, Institute of Neuroscie... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1995730 Wed, 26 Nov 2008 20:04:05 +0100 1995730 FDG-PET/CT of Head and Neck Squamous Cell Carcinoma in a Rat Model http://www.medworm.com/index.php?rid=1995729&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F388p328347u3ur62%2F Conclusions  This study demonstrated that FDG-PET/CT is a feasible examination to detect occult primary tumors in rat models. It is useful to follow tumor progression and evaluate therapeutics efficacy. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0183-yAuthors Karine Aubry, University Hospital Center Department of E.N.T. 2 Avenue Martin Luther-King 87000 Limoges FranceZiyang Shao, Jiao Tong University Department of Radiation Oncology, Ninth People’s Hospital, School of Medicine Shanghai ChinaJacques Monteil, University Hospital Center Department of Nuclear Medicine Limoges FranceFrançois Paraf, University Hospital Center Department of Pathology Limoges FranceJean Pierre Bessède, University Hospital Center Department of E.N.T. 2 Avenue... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1995729 Wed, 26 Nov 2008 20:04:05 +0100 1995729 Comparison of Optical Bioluminescence Reporter Gene and Superparamagnetic Iron Oxide MR Contrast Agent as Cell Markers for Noninvasive Imaging of Cardiac Cell Transplantation http://www.medworm.com/index.php?rid=1995732&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr4x8165812241867%2F Conclusions  Fluc BLI reporter gene imaging is a more accurate gauge of transplanted cell survival as compared to MRI of Feridex-labeled cells. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0182-zAuthors Ian Y. Chen, Stanford University School of Medicine Molecular Imaging Program at Stanford (MIPS) Stanford CA USAJoan M. Greve, Stanford University School of Medicine Department of Bioengineering Stanford CA USAOlivier Gheysens, Stanford University School of Medicine Molecular Imaging Program at Stanford (MIPS) Stanford CA USAJürgen K. Willmann, Stanford University School of Medicine Molecular Imaging Program at Stanford (MIPS) Stanford CA USAMartin Rodriguez-Porcel, Stanford University School of Medicine Molecular Imaging Program at Stanfo... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1995732 Wed, 26 Nov 2008 20:04:04 +0100 1995732 Biodistributions of 177Lu- and 111In-Labeled 7E11 Antibodies to Prostate-Specific Membrane Antigen in Xenograft Model of Prostate Cancer and Potential Use of 111In-7E11 as a Pre-therapeutic Agent for 177Lu-7E11 Radioimmunotherapy http://www.medworm.com/index.php?rid=1995731&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa0h7g47w71010631%2F In conclusion, pharmacokinetic and biodistribution studies of 177Lu-7E11 in LNCaP xenograft mouse models support its potential application as a radioimmunotherapeutic agent targeting prostate cancer, and the distribution and tumor uptake of 111In-7E11 appear to be similar to those of 177Lu-7E11, supporting its use as a pre-therapeutic tool to assess the potential accumulation of 177Lu-7E11 radioimmunotherapeutic at sites of prostate cancer. However, the different accumulation patterns of the 111In and 177Lu immunoconjugates in liver will likely prevent the use of 111In-7E11 as a true dosimetry tool for 177Lu-7E11 radioimmunotherapy. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0185-9Authors Mei-Hsiu Pan, University of California Center for Molecular... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1995731 Wed, 26 Nov 2008 20:04:04 +0100 1995731 In Vivo Imaging of miR-221 Biogenesis in Papillary Thyroid Carcinoma http://www.medworm.com/index.php?rid=1984351&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr46h172003688757%2F Conclusions  These results suggest that the devised CMV/Gluc-3xPT_miR221 system may be a useful tool for monitoring quantities of endogenous miR-221 in cells or living organisms. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0188-6Authors Hyun Joo Kim, Seoul National University Department of Nuclear Medicine, College of Medicine 28 Yeongon-dong, Chongno-gu Seoul 110-744 South KoreaJune-Key Chung, Seoul National University Department of Nuclear Medicine, College of Medicine 28 Yeongon-dong, Chongno-gu Seoul 110-744 South KoreaDo Won Hwang, Seoul National University Department of Nuclear Medicine, College of Medicine 28 Yeongon-dong, Chongno-gu Seoul 110-744 South KoreaDong Soo Lee, Seoul National University Department of Nuclear Medicine, Co... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1984351 Sun, 23 Nov 2008 06:48:32 +0100 1984351 Diffuse Optical Tomography of the Breast: Initial Validation in Benign Cysts http://www.medworm.com/index.php?rid=1984350&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa50747268q79m873%2F Conclusions  DOT can visualize benign cysts in the breast and elucidate their high water and low total hemoglobin content by spectroscopic analysis. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0176-xAuthors Stephanie van de Ven, University Medical Center Utrecht Radiology Utrecht the NetherlandsSjoerd Elias, University Medical Center Utrecht Radiology Utrecht the NetherlandsAndrea Wiethoff, Philips Healthcare Best the NetherlandsMarjolein van der Voort, Philips Research Europe Eindhoven the NetherlandsAnais Leproux, Philips Research Europe Eindhoven the NetherlandsTim Nielsen, Philips Research Europe Eindhoven the NetherlandsBernhard Brendel, Philips Research Europe Eindhoven the NetherlandsLeon Bakker, Philips Research Europe Eindhoven t... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1984350 Sun, 23 Nov 2008 06:48:32 +0100 1984350 Imaging and Pharmacokinetics of 64Cu-DOTA-HB22.7 Administered by Intravenous, Intraperitoneal, or Subcutaneous Injection to Mice Bearing Non-Hodgkin’s Lymphoma Xenografts http://www.medworm.com/index.php?rid=1911010&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn2p403k6234242t3%2F Conclusions  These findings establish 64Cu-DOTA-HB22.7 as a potential radioimmunotherapeutic and/or NHL-specific imaging agent. These findings provide evidence that IP and SQ administration can achieve results equivalent to IV administration and may lead to more efficient, reproducible treatment plans for antibody-based therapeutics. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0148-1Authors Shiloh M. Martin, University of California, Davis Cancer Center Division of Hematology and Oncology, Department of Internal Medicine Davis CA USARobert T. O’Donnell, University of California, Davis Cancer Center Division of Hematology and Oncology, Department of Internal Medicine Davis CA USADavid L. Kukis, University of California Davis Center for ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1911010 Fri, 24 Oct 2008 06:50:48 +0100 1911010 Investigation of the Metabolites of ( S , S )-[11C]MeNER in Humans, Monkeys and Rats http://www.medworm.com/index.php?rid=1811028&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvm4g17hh24j31558%2F Conclusion  It can be concluded that radiometabolites of (S,S)-[11C]MeNER are of minor importance in rat and monkey brain imaging. The presence of a transient lipophilic radiometabolite in peripheral human plasma may induce complications with brain imaging, but its kinetics appear favorable in relation to the slow kinetics of (S,S)-[11C]MeNER in humans. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0175-yAuthors Magnus Schou, Karolinska Hospital Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section S-17176 Stockholm SwedenSami S. Zoghbi, National Institutes of Health Molecular Imaging Branch, National Institute of Mental Health Building 10 Rm. B3 C346A, 10 Center Drive Bethesda MD 20892-1003 USAH. Umesha Shetty, Na... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1811028 Thu, 18 Sep 2008 06:21:52 +0100 1811028 Quantitative PET Imaging of VEGF Receptor Expression http://www.medworm.com/index.php?rid=1789979&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F988744226j838661%2F Conclusion  The tumor uptake of 64Cu-DOTA-VEGF121 measured by small-animal PET imaging reflects tumor VEGFR-2 expression level in vivo. Such correlation may facilitate future treatment planning and treatment monitoring of cancer and potentially other angiogenesis-related diseases. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0172-1Authors Kai Chen, Stanford University School of Medicine The Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program 1201 Welch Rd, P095 Stanford CA 94305-5484 USAWeibo Cai, Stanford University School of Medicine The Molecular Imaging Program at Stanford (MIPS), Department of Radiology and Bio-X Program 1201 Welch Rd, P095 Stanford CA 94305-5484 USAZi-Bo Li, Stanford University Sch... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1789979 Thu, 11 Sep 2008 07:04:06 +0100 1789979 An In Vivo Multimodal Imaging Study Using MRI and PET of Stem Cell Transplantation after Myocardial Infarction in Rats http://www.medworm.com/index.php?rid=1778643&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh2k5u32vk327lx30%2F Conclusions  Noninvasive multimodality imaging allowed us to visualise IO-rBMSCs and establish their affect on cardiac function in a rat model of myocardial infarction (MI). Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0174-zAuthors Catherine Chapon, MRC Clinical Sciences Centre, Imperial College London Stem Cell Imaging Hammersmith Campus, Du Cane Road London W12 0NN UKJohanna S. Jackson, MRC Clinical Sciences Centre, Imperial College London Stem Cell Imaging Hammersmith Campus, Du Cane Road London W12 0NN UKEric O. Aboagye, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Molecular Therapy London UKAmy H. Herlihy, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Biological Imaging Cen... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1778643 Fri, 05 Sep 2008 15:13:30 +0100 1778643 Radioisotopic Localization of 90Yttrium–Ibritumomab Tiuxetan in Patients with CD20+ Non-Hodgkin’s Lymphoma http://www.medworm.com/index.php?rid=1774974&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F158758856741715t%2F Conclusions   90Y-ibritumomab-tiuxetan localizes to the surface membrane of CD20+ lymphoma cells in affected lymph nodes. The patients with the highest quantitative concentration of radioactivity to the lymph node as determined by scintillation counting were observed to have a clinical and FDG-PET/CT response. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0170-3Authors S. A. Jacobs, University of Pittsburgh Medical Center, University of Pittsburgh Cancer Institute and UPMC Cancer Centers Division of Hematology/Oncology Pittsburgh PA 15232 USAA. M. Harrison, University of Pittsburgh Medical Center, University of Pittsburgh Cancer Institute and UPMC Cancer Centers Department of Surgery Pittsburgh PA 15232 USAS. H. Swerdlow, University of Pi... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1774974 Fri, 05 Sep 2008 15:13:29 +0100 1774974 Metabolic Tumor Width Parameters as Determined on PET/CT Predict Disease-free Survival and Treatment Response in Squamous Cell Carcinoma of the Esophagus http://www.medworm.com/index.php?rid=1768136&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl1km530333528513%2F Conclusion  The present study shows that tumor width parameters, especially the tumor diameter or the combination of diameter and SUV in the “diameter-SUV index”, are valuable for predicting tumor-free survival and treatment response independent from the presence of radiation esophagitis. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0169-9Authors Johannes B. Roedl, Massachusetts General Hospital, Harvard Medical School Division of Abdominal and Interventional Radiology, Department of Radiology Boston MA USAElkan F. Halpern, Massachusetts General Hospital, Harvard Medical School Institute for Technology Assessment Boston MA USARivka R. Colen, Massachusetts General Hospital, Harvard Medical School Division of Abdominal and Interventiona... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1768136 Thu, 04 Sep 2008 08:03:59 +0100 1768136 Clinical Value of Image Fusion from MR and PET in Patients with Head and Neck Cancer http://www.medworm.com/index.php?rid=1768135&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv72vlnv58l375h7n%2F Conclusion  Image fusion from MR with PET might be useful in evaluating head and neck cancer, especially in suspected recurrent cases rather than in fresh cases. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0168-xAuthors Yuji Nakamoto, Kyoto University Graduate School of Medicine Department of Diagnostic Imaging and Nuclear Medicine 54 Shogoinkawahara-cho Sakyo-Ku Kyoto 606-8507 JapanKen Tamai, Kyoto University Graduate School of Medicine Department of Diagnostic Imaging and Nuclear Medicine 54 Shogoinkawahara-cho Sakyo-Ku Kyoto 606-8507 JapanTsuneo Saga, National Institute of Radiological Sciences Department of Diagnostic Imaging Molecular Imaging Center 4-9-1 Anagawa Inage-Ku Chiba 263-8555 JapanTatsuya Higashi, Kyoto University Graduate... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1768135 Thu, 04 Sep 2008 08:03:59 +0100 1768135 Endothelial Dysfunction in Recently Diagnosed Type 2 Diabetic Patients Evaluated by PET http://www.medworm.com/index.php?rid=1768137&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F40427133j841336k%2F Conclusions  Asymptomatic, recently diagnosed type 2 diabetes patients present ED that can be quantified by 13N-ammonia–PET. Content Type Journal ArticleCategory Brief ArticleDOI 10.1007/s11307-008-0173-0Authors Erick Alexanderson, Universidad Nacional Autonoma de Mexico (UNAM) PET/CT Cyclotron Unit, Facultad de Medicina Edificio de Investigacion P.B. Facultad de Medicina, Ciudad Universitaria Mexico City 04510 MexicoMónica Rodriguez-Valero, Universidad Nacional Autonoma de Mexico (UNAM) PET/CT Cyclotron Unit, Facultad de Medicina Edificio de Investigacion P.B. Facultad de Medicina, Ciudad Universitaria Mexico City 04510 MexicoAlfonso Martinez, Universidad Nacional Autonoma de Mexico (UNAM) PET/CT Cyclotron Unit, Facultad de Medicina Edificio de Investigacion P.B. Fac... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1768137 Thu, 04 Sep 2008 08:03:58 +0100 1768137 Mechanism of Reduced Myocardial Glucose Utilization During Acute Hypertriglyceridemia in Rats http://www.medworm.com/index.php?rid=1768138&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk5871w6454l80512%2F Conclusions  Hypertriglyceridemia acutely reduces myocardial blood flow and MMRG in rats, but this effect is not explained by increased myocardial fatty acid delivery through intravascular triglyceride lipolysis. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0171-2Authors Sébastien L. Ménard, Centre de Recherche Clinique Etienne-Le Bel, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke Department of Medicine, Division of Endocrinology 3001, 12th Ave. North Sherbrooke QC Canada J1H 5H4Xiuli Ci, Centre de Recherche Clinique Etienne-Le Bel, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke Department of Medicine, Division of Endocrinology 3001, 12th Ave. North Sherbrooke QC Canada J1H 5H4Fréd... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1768138 Thu, 04 Sep 2008 08:03:54 +0100 1768138 Blood Flow and Glucose Metabolism in Stage IV Breast Cancer: Heterogeneity of Response During Chemotherapy http://www.medworm.com/index.php?rid=1713511&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk73l27p1502x4257%2F Conclusion  BF and MRglu changes separately give unique information on different aspects of tumor response to chemotherapy. Changes in BF and MRglu parameters can be remarkably heterogeneous in patients with multiple lesions. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0163-2Authors Nanda Krak, Erasmus Medical Centre Radiology Rotterdam The NetherlandsJacobus van der Hoeven, Erasmus Medical Centre Radiology Rotterdam The NetherlandsOtto Hoekstra, Medical Center Alkmaar Medical Oncology Alkmaar The NetherlandsJos Twisk, VU University Medical Center Nuclear Medicine and PET Research Amsterdam The NetherlandsElsken van der Wall, VU University Medical Center Epidemiology and Biostatistics Amsterdam The NetherlandsAdriaan Lammertsma, University... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1713511 Sun, 17 Aug 2008 13:40:43 +0100 1713511 Dual-Time-Point FDG-PET/CT for the Detection of Hepatic Metastases http://www.medworm.com/index.php?rid=1713510&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu75lp4m4531747h6%2F Conclusions  Dual-time-point-imaging of the liver showed a significant increase of tumor-to-background ratio and hypermetabolic lesion diameter. Although, 30% of all verified liver lesions could only be detected in the second delayed scan 10% of all malignant liver lesions were missed with FDG-PET. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0159-yAuthors Albert Dirisamer, University Hospital Vienna Radiology Vienna AustriaBenjamin S. Halpern, University Hospital Vienna Radiology Vienna AustriaWolfgang Schima, University Hospital Vienna Radiology Vienna AustriaMartin Heinisch, Hospital of Wels Radiology Wels AustriaFlorian Wolf, University Hospital Vienna Radiology Vienna AustriaMohsen Beheshti, St. Vincent’s Hospital Department of Nuc... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1713510 Sun, 17 Aug 2008 13:40:43 +0100 1713510 Quantitative Imaging Biomarkers Alliance FDG–PET/CT Working Group Report http://www.medworm.com/index.php?rid=1713512&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm4572700677q4732%2F Content Type Journal ArticleCategory EditorialDOI 10.1007/s11307-008-0167-yAuthors Richard Frank, GE Healthcare Princeton NJ USA Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1713512 Fri, 15 Aug 2008 06:24:29 +0100 1713512 Imaging Proliferation to Monitor Early Response of Lymphoma to Cytotoxic Treatment http://www.medworm.com/index.php?rid=1713513&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvq761m6837645655%2F Conclusion  In a lymphoma xenotransplant model, we show that positron emission tomography using the proliferation marker FLT is suitable to detect early response to cytotoxic treatment. A significant decrease of FLT uptake but not tumor growth was detectable already 24 h after therapy and correlated with reduced proliferation and induction of apoptosis. Thus, FLT-PET has a potential for imaging early response to treatment in malignant lymphoma. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0162-3Authors Nicolas Graf, Technische Universität München Department of Hematology and Oncology Ismaninger Strasse 22 81675 Munich GermanyKen Herrmann, Technische Universität München Department of Hematology and Oncology Ismaninger Strasse 22 ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1713513 Fri, 15 Aug 2008 06:24:27 +0100 1713513 11C-Methionine-PET for Evaluation of Carbon Ion Radiotherapy in Patients with Pelvic Recurrence of Rectal Cancer http://www.medworm.com/index.php?rid=1685757&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb353527237218464%2F Conclusion   11C-methionine-PET can be used for early prediction of local re-recurrence after CIRT. Because CIRT is local therapy, 11C-methionine-PET cannot predict distant metastasis or survival after CIRT. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0156-1Authors Mitsuru Koizumi, National Institute of Radiological Sciences Diagnostic Imaging, Molecular Imaging Center Anagawa 4-9-1, Inageku Chiba JapanTsuneo Saga, National Institute of Radiological Sciences Diagnostic Imaging, Molecular Imaging Center Anagawa 4-9-1, Inageku Chiba JapanKyosan Yoshikawa, National Institute of Radiological Sciences Clinical Diagnosis Section, Research Center for Charged Particle Therapy Chiba JapanKazutoshi Suzuki, National Institute of Radiological Science... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1685757 Tue, 05 Aug 2008 06:09:20 +0100 1685757 Multimodality Rodent Imaging Chambers for Use Under Barrier Conditions with Gas Anesthesia http://www.medworm.com/index.php?rid=1685758&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F32gvh2405mn20826%2F Conclusions  The rodent imaging chambers were able to reproducibly position rodents in tomographs with a small degree of variability and were compatible with routine use. The embedded anesthetic line and heating system was capable of maintaining the rodent’s temperature and anesthetic state, thereby enhancing rodent health and improving data collection reliability. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0165-0Authors Chris Suckow, David Geffen School of Medicine at UCLA Division of Laboratory Animal Medicine 924 Westwood Boulevard, Suite 1050 Los Angeles CA 90024 USAClaudia Kuntner, Austrian Research Centers GmbH-ARC Radiation Safety and Applications/Radiopharmaceuticals Seibersdorf 2444 AustriaPatrick Chow, Bristol-Myers Squibb N... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1685758 Tue, 05 Aug 2008 06:09:19 +0100 1685758 Radiation Dose Estimates for [18F]5-Fluorouracil Derived from PET-Based and Tissue-Based Methods in Rats http://www.medworm.com/index.php?rid=1685759&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj8773w2147706780%2F Conclusions  Small-animal PET presents an opportunity for providing radiation dose estimates with statistical and logistical advantages over traditional tissue harvesting-based methods. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0160-5Authors Adam L. Kesner, UCLA Medical Center Molecular and Medical Pharmacology, Ahmanson Biological Imaging Division Los Angeles CA USAWei-Ann Hsueh, UCLA Medical Center Molecular and Medical Pharmacology, Ahmanson Biological Imaging Division Los Angeles CA USAJohannes Czernin, UCLA Medical Center Molecular and Medical Pharmacology, Ahmanson Biological Imaging Division Los Angeles CA USAHenry Padgett, Siemens Molecular Imaging Culver City CA USAMichael E. Phelps, UCLA Medical Center Molecular and Medical Ph... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1685759 Tue, 05 Aug 2008 06:09:18 +0100 1685759 An Event-Driven Motion Correction Method for Neurological PET Studies of Awake Laboratory Animals http://www.medworm.com/index.php?rid=1676792&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F840v505364422424%2F Conclusions  This work is an important step towards motion tracking and motion correction in neurological studies of awake animals in the small animal PET imaging environment. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0157-0Authors Victor W Zhou, University of Sydney School of Physics NSW 2006 Sydney AustraliaAndre Z Kyme, University of Sydney School of Physics NSW 2006 Sydney AustraliaSteven R Meikle, University of Sydney Ramaciotti Imaging Centre, Brain and Mind Research Institute NSW 2006 Sydney AustraliaRoger Fulton, University of Sydney School of Physics NSW 2006 Sydney Australia Journal Molecular Imaging and BiologyOnline ISSN 1860-2002Print ISSN 1536-1632 (Source: Molecular Imaging and Biology) Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1676792 Fri, 01 Aug 2008 06:13:08 +0100 1676792 FLT-PET Imaging of Radiation Responses in Murine Tumors http://www.medworm.com/index.php?rid=1676794&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy30t424260192423%2F Conclusion  The kinetics of FLT uptake into murine mammary tumors was altered 1 day after radiation treatment. The dose-dependent response correlated well with in vitro FLT cellular uptake. Parameters (e.g., K i ) derived from FLT kinetics are expected to be useful for assessing the efficacy of irradiation treatment of tumors. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0158-zAuthors M. H. Pan, University of California in Los Angeles Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine 10833 Le Conte Avenue Los Angeles CA 90095 USAS. C. Huang, University of California in Los Angeles Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine 10833 Le Conte Avenue Los An... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1676794 Fri, 01 Aug 2008 06:13:07 +0100 1676794 Automated Method for Small-Animal PET Image Registration with Intrinsic Validation http://www.medworm.com/index.php?rid=1676793&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0757734082u6504m%2F Conclusions  The major advantages of our approach are minimal user interaction and automatic assessment of the registration error, avoiding visual inspection of the results, thus facilitating the accurate, objective, and rapid analysis of large groups of rodent PET images. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0166-zAuthors Javier Pascau, Hospital General Universitario Gregorio Marañón Unidad de Medicina y Cirugía Experimental C/ Doctor Esquerdo 46 28007 Madrid SpainJuan Domingo Gispert, CRC Corporació Sanitària, Parc de Recerca Biomèdica de Barcelona Institut d’Alta Tecnologia Passeig Marítim, 25-29 08003 Barcelona SpainMichael Michaelides, Brookhaven National Laboratory Behavioral Neuropharmacology & Neuroimaging Lab, De... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1676793 Fri, 01 Aug 2008 06:13:07 +0100 1676793 Prospective Comparison of FDG and FET PET/CT in Patients with Head and Neck Squamous Cell Carcinoma http://www.medworm.com/index.php?rid=1674194&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F847514512370x50m%2F Conclusion  Although its good specificity was confirmed, FET did not appear to be suited as a first-line PET tracer in HNSCC imaging and cannot replace FDG for staging due to insufficient sensitivity. However, it was useful in a few selected cases to favor a wait and see attitude when a FDG+ FET− focus was discovered in patients referred for systematic FDG PET during follow-up. In contrast, second primary cancers should not be ruled out if FDG was clearly positive in the lungs or the digestive tract. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0155-2Authors S. Balogova, Hopital Tenon AP-HP and Université Pierre etMarie Curie Department of Nuclear Medicine Paris FranceS. Périé, Hopital Tenon AP-HP and Université Pierre etMarie Curi... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1674194 Thu, 31 Jul 2008 06:43:36 +0100 1674194 Imaging of Fibrogenesis in Patients with Idiopathic Pulmonary Fibrosis with cis -4-[18F]-Fluoro-l -Proline PET http://www.medworm.com/index.php?rid=1670927&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp860024p17740536%2F Conclusions  Due to the low pulmonary uptake of 18F-proline in patients with IPF, 18F-proline does not seem to be a suitable radioligand to evaluate the activity of fibrosis formation in patients with IPF. The low uptake in the lungs of patients with interstitial fibrosis may be explained by the slow nature of fibrogenesis or to the relatively low dose of proline that can be used. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0164-1Authors Jules Lavalaye, St. Antonius Hospital Department of Nuclear Medicine P.O. Box 2500 3430 EM Nieuwegein The NetherlandsJan C. Grutters, St. Antonius Hospital Department of Pulmonology Nieuwegein The NetherlandsEwoudt M. W. van de Garde, St. Antonius Hospital Department of Clinical Pharmacy Nieuwegein The N... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1670927 Wed, 30 Jul 2008 08:16:14 +0100 1670927 FDG-PET/CT for the Evaluation of Response to Therapy of Cutaneous T-cell Lymphoma to Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) in a Phase II Trial http://www.medworm.com/index.php?rid=1670928&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F71276110102m5j21%2F Conclusion  Further study will be required to determine the prognostic value of the initial PET/CT scan and response on follow-up scans. Content Type Journal ArticleCategory Rapid CommunicationDOI 10.1007/s11307-008-0161-4Authors Phillip H. Kuo, Yale University School of Medicine and Yale New Haven Hospital Department of Diagnostic Radiology New Haven 06520-8059 CT USAKacie R. Carlson, Yale University School of Medicine and Yale New Haven Hospital Department of Diagnostic Radiology New Haven 06520-8059 CT USAInger Christensen, Yale University School of Medicine Department of Dermatology New Haven CT USAMichael Girardi, Yale University School of Medicine Department of Dermatology New Haven CT USAPeter W. Heald, Yale University School of Medicine Department of Dermatology ... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1670928 Wed, 30 Jul 2008 08:16:12 +0100 1670928 2-Deoxy-2[F-18]FDG-PET for Detection of Recurrent Laryngeal Carcinoma after Radiotherapy: Interobserver Variability in Reporting http://www.medworm.com/index.php?rid=1624950&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe6658j5262753520%2F Conclusions  FDG-PET has acceptable interobserver agreement and yields good negative predictive value for detection of recurrent laryngeal carcinoma. It could therefore be used as first diagnostic step and may reduce futile invasive diagnostics. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0154-3Authors L. van der Putten, VU University Medical Center Department of Otolaryngology/Head and Neck Surgery De Boelelaan 1117 1081 HV Amsterdam The NetherlandsO. S. Hoekstra, VU University Medical Center Department of Nuclear Medicine and PET Research Amsterdam The NetherlandsR. de Bree, VU University Medical Center Department of Otolaryngology/Head and Neck Surgery De Boelelaan 1117 1081 HV Amsterdam The NetherlandsD. J. Kuik, VU University Medical... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1624950 Sat, 12 Jul 2008 06:51:11 +0100 1624950 Human Breast Tumor Cells Express Multimodal Imaging Reporter Genes http://www.medworm.com/index.php?rid=1530476&cid=s_33330_67_f&fid=33330&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx4j4j41737267344%2F Conclusions  This study confirmed the usefulness of eGFP-tk in many applications by providing, in vitro and in vivo, the sensitive and reporter gene-specific imaging. ZR75-1-eGFP-tk cells that are ready to incorporate in various imaging platforms constitute a useful model in breast cancer research. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-008-0147-2Authors Kurt M. Lin, National Health Research Institutes Division of Medical Engineering Research R1-1027, No. 35, Keyan Road Zhunan Town Miaoli County 350, Taiwan Republic of ChinaChing-Han Hsu, National Health Research Institutes Division of Medical Engineering Research R1-1027, No. 35, Keyan Road Zhunan Town Miaoli County 350, Taiwan Republic of ChinaWun-Shaing W. Chang, National Health Resear... Molecular Imaging and Biology journals http://www.medworm.com/rss/comments.php?id=1530476 Tue, 17 Jun 2008 09:59:00 +0100 1530476