MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Movement Disorders' source. Wed, 08 Feb 2012 20:43:24 +0100 http://www.medworm.com/index.php?rid=5668710&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24940 AbstractConcerns have been raised that persons with serious illnesses participating in high‐risk research, such as PD patients in sham surgery trials, have unrealistic expectations and are vulnerable to exploitation. A comparison of enrollees and decliners of such research may provide insights about the adequacy of decision making by potential subjects. We compared 61 enrollees and 10 decliners of two phase II neurosurgical intervention (i.e., cellular and gene transfer) trials for PD regarding their demographic and clinical status, perceptions and attitudes regarding research risks, potential direct benefit, and societal benefit, and perspectives on the various potential reasons for and against participation. In addition to bivariate analyses, a logistic regression model examined variab... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5668710 Tue, 07 Feb 2012 05:00:00 +0100 5668710 http://www.medworm.com/index.php?rid=5668709&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24916 Conclusions:We are not aware of any prior reports of such a dramatic reaction to DBS placement to date. © 2012 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5668709 Tue, 07 Feb 2012 05:00:00 +0100 5668709 http://www.medworm.com/index.php?rid=5668712&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24890 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5668712 Mon, 06 Feb 2012 05:00:00 +0100 5668712 http://www.medworm.com/index.php?rid=5668711&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24067 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5668711 Mon, 06 Feb 2012 05:00:00 +0100 5668711 http://www.medworm.com/index.php?rid=5660905&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24941 Conclusions:Increased monoaminergic activity in the medial orbitofrontal cortex might be associated with increased sensitivity for ICDs under dopamine‐replacement therapy in PD. © 2012 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5660905 Sun, 05 Feb 2012 05:00:00 +0100 5660905 http://www.medworm.com/index.php?rid=5650103&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24930 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5650103 Mon, 30 Jan 2012 05:00:00 +0100 5650103 http://www.medworm.com/index.php?rid=5650102&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24928 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5650102 Mon, 30 Jan 2012 05:00:00 +0100 5650102 http://www.medworm.com/index.php?rid=5650101&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24926 We report that an abnormal brain iron accumulation is a marker for ongoing neurodegeneration in both conditions, but the conditions differ with respect to the anatomical distribution of these accumulations. We analyzed quantitative T2′ maps as markers of regional brain iron content from PD and progressive supranuclear palsy patients and compared them to age‐matched control subjects. T2‐weighted and T2*‐weighted images were acquired in 30 PD patients, 12 progressive supranuclear palsy patients, and 24 control subjects at 1.5 Tesla. Mean T2′ values were determined in regions‐of‐interest in the basal ganglia, thalamus, and white matter within each hemisphere. The main findings were shortened T2′ values in the caudate nucleus, globus pallidus, and putamen in progressive supranu... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5650101 Mon, 30 Jan 2012 05:00:00 +0100 5650101 http://www.medworm.com/index.php?rid=5650100&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24922 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5650100 Mon, 30 Jan 2012 05:00:00 +0100 5650100 http://www.medworm.com/index.php?rid=5650099&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24917 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5650099 Mon, 30 Jan 2012 05:00:00 +0100 5650099 http://www.medworm.com/index.php?rid=5650098&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24905 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5650098 Mon, 30 Jan 2012 05:00:00 +0100 5650098 http://www.medworm.com/index.php?rid=5650097&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24909 Conclusions:The results of this pilot trial need to be confirmed by further studies on a larger number of patients. © 2012 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5650097 Mon, 30 Jan 2012 05:00:00 +0100 5650097 http://www.medworm.com/index.php?rid=5639523&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24923 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5639523 Fri, 27 Jan 2012 05:00:00 +0100 5639523 http://www.medworm.com/index.php?rid=5639522&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24911 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5639522 Fri, 27 Jan 2012 05:00:00 +0100 5639522 http://www.medworm.com/index.php?rid=5639521&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24897 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5639521 Fri, 27 Jan 2012 05:00:00 +0100 5639521 http://www.medworm.com/index.php?rid=5639520&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24894 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5639520 Fri, 27 Jan 2012 05:00:00 +0100 5639520 http://www.medworm.com/index.php?rid=5639519&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24064 Conclusions:The rare genetic ataxias examined here do not significantly contribute to sporadic cerebellar ataxia in our tertiary care population. © 2012 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5639519 Fri, 27 Jan 2012 05:00:00 +0100 5639519 http://www.medworm.com/index.php?rid=5630532&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24913 Conclusions:Echopraxia is a hallmark of Tourette syndrome. © 2012 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5630532 Wed, 25 Jan 2012 05:00:00 +0100 5630532 http://www.medworm.com/index.php?rid=5630533&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24893 This article provides guidelines to characterize the clinical syndrome and methods for its diagnosis. The criteria will require validation, and possibly refinement, as additional research improves our understanding of the epidemiology, presentation, neurobiology, assessment, and long‐term course of this clinical syndrome. These diagnostic criteria will support future research efforts to identify at the earliest stage those PD patients at increased risk of progressive cognitive decline and dementia who may benefit from clinical interventions at a predementia stage. © 2012 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5630533 Tue, 24 Jan 2012 05:00:00 +0100 5630533 http://www.medworm.com/index.php?rid=5611152&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24899 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5611152 Thu, 19 Jan 2012 05:00:00 +0100 5611152 http://www.medworm.com/index.php?rid=5611151&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24907 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5611151 Thu, 19 Jan 2012 05:00:00 +0100 5611151 http://www.medworm.com/index.php?rid=5599397&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24061 AbstractAbout one‐third of patients with Parkinson's disease (PD) are diagnosed with apathy in cross‐sectional studies. However, once patients with concomitant depression and dementia are excluded, the frequency of apathy drops to 5% to 10%. Several scales have been recommended to rate apathy in PD, but specific psychiatric interviews have not been developed, and recently proposed standardized diagnostic criteria are still in the validation process. Most studies assessing the association between subthalamic deep brain stimulation (STN‐DBS) and apathy have reported a relative increase in the frequency and severity of apathy, although discrepant findings have also been reported. Several mechanisms to explain apathy in PD have been proposed, from dopaminergic imbalances in frontal‐bas... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5599397 Wed, 11 Jan 2012 05:00:00 +0100 5599397 http://www.medworm.com/index.php?rid=5599396&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24892 AbstractTo test the association between impaired olfaction and other prodromal features of PD in the Parkinson At‐Risk Syndrome Study. The onset of olfactory dysfunction in PD typically precedes motor features, suggesting that olfactory testing could be used as a screening test. A combined strategy that uses other prodromal nonmotor features, along with olfactory testing, may be more efficient than hyposmia alone for detecting the risk of PD. Individuals with no neurological diagnosis completed a mail survey, including the 40‐item University of Pennsylvania Smell Identification Test, and questions on prodromal features of PD. The frequency of reported nonmotor features was compared across individuals with and without hyposmia. A total of 4,999 subjects completed and returned the survey... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5599396 Wed, 11 Jan 2012 05:00:00 +0100 5599396 http://www.medworm.com/index.php?rid=5599395&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24070 Conclusions:Substantia nigra hyperechogenicity does not reflect the degree of the nigrostriatal degeneration or the clinical state of the disease progression. © 2012 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5599395 Wed, 11 Jan 2012 05:00:00 +0100 5599395 http://www.medworm.com/index.php?rid=5599394&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24887 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5599394 Wed, 11 Jan 2012 05:00:00 +0100 5599394 http://www.medworm.com/index.php?rid=5599398&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24054 AbstractPain has been studied more intensely as a symptom of Parkinson's disease (PD) in recent years. However, studies on the characteristics and prevalence of pain in PD have yielded conflicting results, prompting us to do a systematic review of the literature. A systematic review of the literature was conducted, using different databases. The last inclusion date was March 15, 2011. The modified Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool was used, which is especially designed for judging prevalence studies on their methodological quality. Only articles that met the predefined criteria were used in this review. We found 18 articles, of which only 8 met the methodological criteria. Prevalence frequency ranges from 40% to 85% with a mean of 67.6%. Pain is most frequentl... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5599398 Mon, 09 Jan 2012 05:00:00 +0100 5599398 http://www.medworm.com/index.php?rid=5562001&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24886 AbstractLysosomal protein 2 (LIMP2), the product of the scavenger receptor class B member 2 (SCARB2) gene, is a ubiquitously expressed transmembrane protein that is the mannose‐6‐phosphate–independent receptor for glucocerebrosidase (β‐GCase); a deficiency in this protein causes Gaucher disease. Several studies have shown a link between mutations in the β‐GCase gene and diseases characterized clinically by Parkinsonism and by the presence of Lewy body–related pathology. We hypothesized that genetic variants in the SCARB2 gene could be risk factors for Parkinson's disease (PD). A candidate‐gene study of 347 Greek patients with sporadic PD and 329 healthy controls was conducted to investigate the association between 5 polymorphisms in the SCARB2 gene (rs6824953, rs6825004, rs... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5562001 Thu, 05 Jan 2012 05:00:00 +0100 5562001 http://www.medworm.com/index.php?rid=5562000&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24048 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5562000 Thu, 05 Jan 2012 05:00:00 +0100 5562000 http://www.medworm.com/index.php?rid=5561999&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24040 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5561999 Thu, 05 Jan 2012 05:00:00 +0100 5561999 http://www.medworm.com/index.php?rid=5562008&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24888 AbstractIt has long been recognized that lesions of the basal ganglia frequently result in dysarthria, in part because many individuals with Parkinson's disease (PD) have impaired speech. Earlier studies of speech production in PD using perceptual, acoustic, and/or kinematic analyses have yielded mixed findings about the characteristics of articulatory movements underlying hypokinetic dysarthria associated with PD: in some cases reporting reduced articulatory output, and in other instances revealing orofacial movement parameters within the normal range. The central aim of this experiment was to address these inconsistencies by providing an integrative description of basic kinematic and acoustic parameters of speech production in individuals with PD. Recordings of lip and jaw movements and ... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5562008 Wed, 04 Jan 2012 05:00:00 +0100 5562008 http://www.medworm.com/index.php?rid=5562007&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24902 Conclusion:An atypical position of the STN does not need to complicate DBS surgery, if detected by a combination of MRI‐based targeting and electrophysiological guidance. © 2012 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5562007 Wed, 04 Jan 2012 05:00:00 +0100 5562007 http://www.medworm.com/index.php?rid=5562006&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24903 Conclusions:Diagnosis according to clinical available criteria for PMD yields poor diagnostic agreement. © 2012 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5562006 Wed, 04 Jan 2012 05:00:00 +0100 5562006 http://www.medworm.com/index.php?rid=5562005&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24035 AbstractDeep brain stimulation of the subthalamic nucleus is an effective treatment for the motor symptoms of Parkinson's disease. Although a range of psychiatric and behavioral problems have been documented following deep brain stimulation, the short‐term effects of subthalamic nucleus stimulation on patients' mood have only been investigated in a few studies. Our aim was to compare self‐reported mood in Parkinson's patients with deep brain stimulation of the subthalamic nucleus ON versus OFF. Twenty‐three Parkinson's patients with bilateral deep brain stimulation of the subthalamic nucleus and 11 unoperated Parkinson's patients completed a mood visual analogue scale twice. Operated patients were tested with deep brain stimulation of the subthalamic nucleus both ON and OFF. All were... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5562005 Wed, 04 Jan 2012 05:00:00 +0100 5562005 http://www.medworm.com/index.php?rid=5562004&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24066 AbstractBackground:Friedreich ataxia is a rare disease caused by GAA‐trinucleotide‐repeat expansions in the frataxin gene, leading to marked reduction of qualitatively normal frataxin protein. Recently, human recombinant erythropoietin was reported to increase frataxin levels in patients with Friedreich ataxia.Methods:We performed a 6‐month, randomized placebo‐controlled, double‐blind, dose‐response pilot trial to assess the safety and efficacy of erythropoietin in increasing frataxin levels. Sixteen adult patient with Friedreich ataxia were randomly assigned to erythropoietin (n = 11) or matching placebo (n = 5). All patients continued Idebenone treatment (5 mg/kg/day). Treatment consisted of a 6‐month scaling‐up phase, in which erythropoietin was administered intravenousl... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5562004 Wed, 04 Jan 2012 05:00:00 +0100 5562004 http://www.medworm.com/index.php?rid=5562003&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24889 AbstractThe purpose of this study was to evaluate the incidence of augmentation over 66 weeks of treatment with ropinirole in patients with primary restless legs syndrome (RLS). Augmentation is the main complication of long‐term dopaminergic treatment of RLS. Despite widespread use of ropinirole in RLS, no studies have prospectively and systematically assessed the incidence of augmentation with its use. The study consisted of 26 weeks of double‐blind flexible‐dose treatment with ropinirole or placebo, followed by 40 weeks of open‐label ropinirole treatment.. Patients had no previous history of augmentation. Potential cases of augmentation were identified with the Structured Interview for the Diagnosis of Augmentation and the Augmentation Severity Rating Scale and through reporting ... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5562003 Wed, 04 Jan 2012 05:00:00 +0100 5562003 http://www.medworm.com/index.php?rid=5562002&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24900 AbstractVisual misperception and hallucinations represent a major problem in advanced PD. The pathophysiological mechanisms underlying these symptoms remain poorly understood, with limited tests for their assessment. A recent hypothesis has suggested that visual misperception and hallucinations may arise from disrupted processing in the attentional networks. To assess and quantify visual misperceptions, we developed the novel bistable percept paradigm (BPP), which consists of a battery of “single” and “hidden” monochromatic images that subjects are required to study until they are satisfied that they have recognized everything that the image may represent. In this experiment, 45 patients and 18 age‐matched controls performed the BPP. Using an error score value derived from the co... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5562002 Wed, 04 Jan 2012 05:00:00 +0100 5562002 http://www.medworm.com/index.php?rid=5668708&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24918 Conclusions:PD patients adhere less than controls to a Mediterranean‐type diet. Dietary behavior may be associated with age at onset. © 2012 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5668708 Sun, 01 Jan 2012 05:00:00 +0100 5668708 http://www.medworm.com/index.php?rid=5660904&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24906 Conclusions:For correct determination of rearrangement mutation, mutation analysis of the patient as well as other family members and/or break‐point analysis of genomic DNA and at the transcript level should be conducted. © 2012 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5660904 Sun, 01 Jan 2012 05:00:00 +0100 5660904 http://www.medworm.com/index.php?rid=5650096&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24929 Conclusions:The cardiac autonomic state of multiple system atrophy was characterized by decreases in both sympathetic and parasympathetic tones. Because heart rate variability parameters were not affected by other autonomic dysfunctions, this may be a useful method for evaluating cardiac autonomic dysfunction in multiple system atrophy. © 2012 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5650096 Sun, 01 Jan 2012 05:00:00 +0100 5650096 http://www.medworm.com/index.php?rid=5639518&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24898 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5639518 Sun, 01 Jan 2012 05:00:00 +0100 5639518 http://www.medworm.com/index.php?rid=5630531&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24927 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5630531 Sun, 01 Jan 2012 05:00:00 +0100 5630531 http://www.medworm.com/index.php?rid=5611150&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24901 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5611150 Sun, 01 Jan 2012 05:00:00 +0100 5611150 http://www.medworm.com/index.php?rid=5599404&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23987 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5599404 Sun, 01 Jan 2012 05:00:00 +0100 5599404 http://www.medworm.com/index.php?rid=5599403&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24063 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5599403 Sun, 01 Jan 2012 05:00:00 +0100 5599403 http://www.medworm.com/index.php?rid=5599402&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24051 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5599402 Sun, 01 Jan 2012 05:00:00 +0100 5599402 http://www.medworm.com/index.php?rid=5599401&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24047 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5599401 Sun, 01 Jan 2012 05:00:00 +0100 5599401 http://www.medworm.com/index.php?rid=5599400&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24046 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5599400 Sun, 01 Jan 2012 05:00:00 +0100 5599400 http://www.medworm.com/index.php?rid=5599399&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24885 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5599399 Sun, 01 Jan 2012 05:00:00 +0100 5599399 http://www.medworm.com/index.php?rid=5599393&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24908 Conclusions:Posturography may provide useful objective and quantitative measures of postural motor dysfunction in Huntington's disease. © 2012 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5599393 Sun, 01 Jan 2012 05:00:00 +0100 5599393 http://www.medworm.com/index.php?rid=5553301&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24053 Conclusions:To prevent seizures the current density should be lowered, so that motor cortex stimulation‐evoked responses can be safely used during deep brain stimulation surgery. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5553301 Fri, 30 Dec 2011 05:00:00 +0100 5553301 http://www.medworm.com/index.php?rid=5506761&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24028 Conclusions:Web‐based assessments offer a feasible format for assessing PD‐related impairment from home. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506761 Thu, 15 Dec 2011 05:00:00 +0100 5506761 http://www.medworm.com/index.php?rid=5506760&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24026 Conclusions:Eye symptoms reported by relatives of patients with focal dystonia probably result from eye diseases and are not part of the clinical spectrum of blepharospasm. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506760 Thu, 15 Dec 2011 05:00:00 +0100 5506760 http://www.medworm.com/index.php?rid=5506759&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24022 Conclusions:Patients who had prior peripheral surgery for cervical dystonia experience improvement from subsequent pallidal stimulation that is comparable to that of de novo patients. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506759 Thu, 15 Dec 2011 05:00:00 +0100 5506759 http://www.medworm.com/index.php?rid=5506758&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24011 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506758 Thu, 15 Dec 2011 05:00:00 +0100 5506758 http://www.medworm.com/index.php?rid=5506757&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24042 AbstractAlthough Parkinson's disease (PD) is traditionally considered a motor output disorder, recent evidence suggests that people with PD may have sensory and perceptual impairments that may underlie movement impairments. Yet there has not been any direct testing of perceptual judgments, especially when manipulating the sensory feedback on which these judgments are made. The present study investigated how perception might be influenced by sensory feedback to contribute to height estimations and obstacle stepping in PD relative to healthy age‐matched control participants. Perceptual judgment accuracy was evaluated by judging 3 typically encountered obstacle heights in 2 sensory feedback conditions: (1) vision of foot available and (2) without vision of foot (reliance on proprioceptive f... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506757 Thu, 15 Dec 2011 05:00:00 +0100 5506757 http://www.medworm.com/index.php?rid=5506756&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24024 The objective of this study was to further explore the effect of CAG repeat length on the rate of clinical progression in patients with Huntington's disease. The dataset included records for 569 subjects followed prospectively at the Baltimore Huntington's Disease Center. Participants were seen for a mean of 7.1 visits, with a mean follow‐up of 8.2 years. Subjects were evaluated using the Quantified Neurologic Examination and its Motor Impairment subscale, the Mini‐Mental State Examination, and the Huntington's disease Activities of Daily Living Scale. By itself, CAG repeat length showed a statistically significant but small effect on the progression of all clinical measures. Contrary to our previous expectations, controlling for age of onset increased the correlation between CAG repea... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506756 Thu, 15 Dec 2011 05:00:00 +0100 5506756 http://www.medworm.com/index.php?rid=5506755&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24014 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506755 Thu, 15 Dec 2011 05:00:00 +0100 5506755 http://www.medworm.com/index.php?rid=5506754&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24069 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506754 Thu, 15 Dec 2011 05:00:00 +0100 5506754 http://www.medworm.com/index.php?rid=5506753&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24044 Conclusions:These characteristics of movements were found in the 3 conditions (Parkinson's disease, idiopathic RBD, and primary narcolepsy), delineating a common motor signature of RBD. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506753 Thu, 15 Dec 2011 05:00:00 +0100 5506753 http://www.medworm.com/index.php?rid=5495972&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24021 Conclusions:Our cases suggest that the definition of the FXTAS may need to be broadened to include individuals with FMR1 repeat expansions in the gray zone. These neurological signs may be due to elevated levels of expanded CGG repeat FMR1 mRNA in the gray zone carriers, similar to the changes seen in premutation carriers with FXTAS. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5495972 Sun, 11 Dec 2011 05:00:00 +0100 5495972 http://www.medworm.com/index.php?rid=5488524&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24062 Conclusions:In Huntington's disease, behavior seems to be more vulnerable to placebo than overall motor function, cognition, and function © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5488524 Fri, 09 Dec 2011 05:00:00 +0100 5488524 http://www.medworm.com/index.php?rid=5488523&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24065 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5488523 Fri, 09 Dec 2011 05:00:00 +0100 5488523 http://www.medworm.com/index.php?rid=5488522&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24038 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5488522 Fri, 09 Dec 2011 05:00:00 +0100 5488522 http://www.medworm.com/index.php?rid=5488521&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23983 Conclusions:Perampanel failed to significantly improve motor symptoms versus placebo. There was also no effect on the duration or disability of levodopa‐induced dyskinesia. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5488521 Fri, 09 Dec 2011 05:00:00 +0100 5488521 http://www.medworm.com/index.php?rid=5488520&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23989 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5488520 Fri, 09 Dec 2011 05:00:00 +0100 5488520 http://www.medworm.com/index.php?rid=5488519&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24025 AbstractParkinson's disease provides a useful model for studying the neural substrates of emotional processing. The striato‐thalamo‐cortical circuits, like the mesolimbic dopamine system that modulates their function, are thought to be involved in emotional processing. As Parkinson's disease is histopathologically characterized by the selective, progressive, and chronic degeneration of the nigrostriatal and mesocorticolimbic dopamine systems, it can therefore serve as a model for assessing the functional role of these circuits in humans. In the present review, we begin by providing a synopsis of the emotional disturbances observed in Parkinson's disease. We then discuss the functional roles of the striato‐thalamo‐cortical and mesolimbic circuits, ending with the conclusion that bot... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5488519 Fri, 09 Dec 2011 05:00:00 +0100 5488519 http://www.medworm.com/index.php?rid=5488518&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24033 Conclusions:This is the first report describing an Asian PD family with the p.Tyr1699Cys mutation in LRRK2. The affected members of this family showed clinical heterogeneity. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5488518 Fri, 09 Dec 2011 05:00:00 +0100 5488518 http://www.medworm.com/index.php?rid=5488517&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24034 Conclusions:Our findings suggest that the bilateral pedunculopontine nucleus, bilateral superior premotor cortex, right orbitofrontal area, and left supplement motor area are closely related to freezing of gait. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5488517 Fri, 09 Dec 2011 05:00:00 +0100 5488517 http://www.medworm.com/index.php?rid=5488516&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24058 AbstractRestless leg syndrome (RLS) is a major healthcare burden with increasing prevalence. It has been demonstrated that periodic limb movements (PLM) can occur as an isolated phenomenon, but they are often associated with this syndrome and are the only symptom of this disorder that can be measured electrophysiologically. The aim of this study was to examine the sleep‐wake behavior and the presence of limb movement in a rat model of RLS induced by lesioning the A11 dopaminergic nuclei with the neurotoxin 6‐hydroxydopamine (6‐OHDA). Rats were implanted with electrodes for electrocorticography and electromyography. Sleep recordings were monitored during light/dark periods lasting 12 hours each and were evaluated on days 7, 15, and 28 after injection of the drug or phosphate‐buffere... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5488516 Fri, 09 Dec 2011 05:00:00 +0100 5488516 http://www.medworm.com/index.php?rid=5488515&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24059 The objective of this work was to evaluate the Movement Disorders Society (MDS) Task Force–proposed screening checklist for detecting Parkinson's disease dementia (PD‐D) in relation to full neuropsychological testing. An MDS Task Force has proposed diagnostic procedures for PD‐D, which have not been fully validated against more extensive neuropsychological testing. PD subjects were recruited from 2 specialty centers. A neuropsychologist evaluated them for dementia as part of routine clinical care. Independent clinical neurologists administered the MDS PD‐D screening checklist. Diagnosis of PD‐D by the 2 methods was compared. Ninety‐one PD subjects had a mean age of 66.3 (SD = 9.7) years and a mean PD duration of 8.8 (SD = 6.1) years. Seven subjects (7.7%) met all 8 screening ch... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5488515 Fri, 09 Dec 2011 05:00:00 +0100 5488515 http://www.medworm.com/index.php?rid=5488514&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23994 AbstractThe foundations of the clinical classification of movement disorders rest on the precise definition of the words used to describe the disorders. Here we argue that the current use of the term stereotypy falls well short of the precision needed for either clinical or academic use, and fails both to provide a clinically useful diagnostic category and to define a set of conditions that are linked pathophysiologically. The difficulty in defining this concept is not a new one as our review of the history of the term demonstrates. We synthesise this historical background, explore why clinicians have felt it necessary to use the category of stereotypy for certain movements rather than the related category of tics, discuss the multiple uses of the term in current research and clinical prac... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5488514 Fri, 09 Dec 2011 05:00:00 +0100 5488514 http://www.medworm.com/index.php?rid=5561998&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24019 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5561998 Thu, 01 Dec 2011 05:00:00 +0100 5561998 http://www.medworm.com/index.php?rid=5553300&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24016 AbstractWe aimed to examine associations among serum 25‐hydroxyvitamin D levels, 1,25‐dihyroxyvitamin D levels, vitamin D receptor polymorphisms, vitamin D binding protein gene polymorphisms, and the severity of Parkinson's disease. In 137 patients, the severity of Parkinson's disease was evaluated using Hoehn & Yahr stage and Unified Parkinson's Disease Rating Stage by neurologists and compared with 25‐hydroxyvitamin D, 1,25‐hydroxyvitamin D, vitamin D receptor polymorphisms, ie, FokI (rs10735810), BsmI (rs1544410), Cdx2 (rs11568820), ApaI (rs7976091), and TaqI (rs731236), and vitamin D binding protein gene polymorphisms GC1 (rs7041)/GC2 (rs4588) in a cross‐sectional study. Mean ± standard deviation levels of 25‐hydroxyvitamin D were 21.1 ± 9.0 ng/mL. Levels were deficie... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5553300 Thu, 01 Dec 2011 05:00:00 +0100 5553300 http://www.medworm.com/index.php?rid=5526969&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24049 Conclusions:Patients with Parkinson's disease, essential tremor, and dystonia had elevated apathy scores. Features of apathy seemed to occur in these conditions independent of depressive symptoms. The mechanistic basis for the apparent increased features of apathy in essential tremor and dystonia deserves further study. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5526969 Thu, 01 Dec 2011 05:00:00 +0100 5526969 http://www.medworm.com/index.php?rid=5506774&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24043 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506774 Thu, 01 Dec 2011 05:00:00 +0100 5506774 http://www.medworm.com/index.php?rid=5506773&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23981 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506773 Thu, 01 Dec 2011 05:00:00 +0100 5506773 http://www.medworm.com/index.php?rid=5506772&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24056 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506772 Thu, 01 Dec 2011 05:00:00 +0100 5506772 http://www.medworm.com/index.php?rid=5506771&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24057 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506771 Thu, 01 Dec 2011 05:00:00 +0100 5506771 http://www.medworm.com/index.php?rid=5506770&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24032 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506770 Thu, 01 Dec 2011 05:00:00 +0100 5506770 http://www.medworm.com/index.php?rid=5506769&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24031 AbstractShort sequences in the Wilson film illustrate clinical aspects of bradykinesia and tremor in Parkinson's disease. What might have been the motivation of Wilson to capture these symptoms, and how would we view them today? © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506769 Thu, 01 Dec 2011 05:00:00 +0100 5506769 http://www.medworm.com/index.php?rid=5506768&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24037 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506768 Thu, 01 Dec 2011 05:00:00 +0100 5506768 http://www.medworm.com/index.php?rid=5506767&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24010 AbstractAction tremor was for a long time considered to be a defining symptom of multiple sclerosis. The Wilson films include a short segment showing a female patient suffering from relatively severe action tremor. Tremor is the most common movement disorder in multiple sclerosis, and can be very disabling in some patients. Insights into the frequency and treatment of tremor in multiple sclerosis have changed since the Wilson films were taken, and are reviewed herein. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506767 Thu, 01 Dec 2011 05:00:00 +0100 5506767 http://www.medworm.com/index.php?rid=5506766&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23995 AbstractThe case presented involves an 88‐year‐old woman with sudden onset of right‐sided hemiballism that persisted for an amazing 15 years. The video demonstrates wide amplitude choreic movements of the proximal and distal limbs of the right side, as well as of the axial musculature. Classical teaching dictates that this patient has a lesion in the subthalamic nucleus. Here then is a prime example where classical teaching is wrong! © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506766 Thu, 01 Dec 2011 05:00:00 +0100 5506766 http://www.medworm.com/index.php?rid=5506765&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23992 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506765 Thu, 01 Dec 2011 05:00:00 +0100 5506765 http://www.medworm.com/index.php?rid=5506764&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23986 AbstractWilson's Queen Square Case 9 with Huntington's chorea shows a 68‐year‐old man with mild to moderate generalized chorea, impaired fixation, and probable cognitive decline in keeping with a diagnosis of Huntington's disease (HD). An age of onset in the late sixties and a negative family history suggest a relatively small expanded trinucleotide repeat in the HTT gene in the patient and reduced penetrance of an even shorter repeat allele in one of his parents. A highly sensitive and specific gene test has been offered worldwide for diagnostic testing of HD for almost two decades. This test, obviously unavailable at Wilson's times, became the historic frontrunner for guidelines of symptomatic, presymptomatic, and prenatal testing for an adult‐onset neurodegenerative disorder. Rega... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506764 Thu, 01 Dec 2011 05:00:00 +0100 5506764 http://www.medworm.com/index.php?rid=5506763&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23927 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506763 Thu, 01 Dec 2011 05:00:00 +0100 5506763 http://www.medworm.com/index.php?rid=5506762&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23900 AbstractThree cases of postencephalitic parkinsonism that were originally described by Kinnier Wilson are reviewed and some general comments made upon their presentation. A differential diagnosis that might now be appropriate in the 21st Century is given, in the light of recent literature on the topic and so‐called “sporadic” cases. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506762 Thu, 01 Dec 2011 05:00:00 +0100 5506762 http://www.medworm.com/index.php?rid=5506752&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24045 AbstractMutations in the glucocerebrosidase gene are associated with Parkinson's disease and Lewy body dementia. However, whether these alterations have any effect on the clinical course of Parkinson's disease is not clear. The glucocerebrosidase coding region was fully sequenced in 225 Parkinson's disease patients, 17 pathologically confirmed Lewy body dementia patients, and 186 controls from Spain. Twenty‐two Parkinson's disease patients (9.8%) and 2 Lewy body dementia patients (11.8%) carried mutations in the glucocerebrosidase gene, compared with only 1 control (0.5%); P = .016 and P = .021 for Parkinson's disease and Lewy body dementia, respectively. The N370S and the L444P mutations represented 50% of the alterations. Two novel variants, L144V and S488T, and 7 previously described ... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5506752 Thu, 01 Dec 2011 05:00:00 +0100 5506752 http://www.medworm.com/index.php?rid=5470275&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24001 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5470275 Thu, 01 Dec 2011 05:00:00 +0100 5470275 http://www.medworm.com/index.php?rid=5442987&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23998 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5442987 Wed, 23 Nov 2011 05:00:00 +0100 5442987 http://www.medworm.com/index.php?rid=5442989&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24030 Conclusions:Cerebellar function may be required for the general precision of interval timing, whereas basal ganglia rather serve to maintain rhythm stability over time. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5442989 Tue, 22 Nov 2011 05:00:00 +0100 5442989 http://www.medworm.com/index.php?rid=5442988&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24060 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5442988 Tue, 22 Nov 2011 05:00:00 +0100 5442988 http://www.medworm.com/index.php?rid=5423728&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24000 AbstractDopamine transporter single‐photon emission computerized tomography can visualize dopaminergic degeneration in Parkinson's disease and multiple system atrophy. Some studies have suggested that dopamine transporter imaging can distinguish these disorders based on a more diffuse and symmetric striatal dopamine transporter binding loss in multiple system atrophy. The present study compared patterns of striatal dopamine transporter distribution in postmortem‐confirmed Parkinson's disease and multiple system atrophy. Patients with a postmortem diagnosis of multiple system atrophy (n = 6) or Parkinson's disease (n = 8) who had undergone dopamine transporter imaging were included. Imaging had been performed after a mean disease duration of 3.6 and 4.1 years in multiple system atrophy ... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5423728 Fri, 18 Nov 2011 05:00:00 +0100 5423728 http://www.medworm.com/index.php?rid=5423730&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23847 AbstractSensitive outcome measures for patients with Huntington's disease (HD) are required for future clinical trials. Longitudinal data were collected from a 3‐year study of 379 patients suffering from early HD who were not treated by antipsychotics. Progression of UHDRS item scores was evaluated by linear regression and slope, whereas correlation coefficient, standard error, and P values were estimated on the basis of the data of eight evaluations from screening to study end (36 months). For the functional assessment dimension, the proportion of “no” responses at baseline and at study end was determined. Linear progression was observed for the motor score and for all three functional measures (i.e., functional assessment score, independence assessment score, and total functional c... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5423730 Thu, 17 Nov 2011 05:00:00 +0100 5423730 http://www.medworm.com/index.php?rid=5423729&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23999 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5423729 Thu, 17 Nov 2011 05:00:00 +0100 5423729 http://www.medworm.com/index.php?rid=5410466&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24050 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5410466 Wed, 16 Nov 2011 05:00:00 +0100 5410466 http://www.medworm.com/index.php?rid=5410468&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23805 Conclusions:This finding suggests that genetic factors may affect susceptibility to dyskinesias in PD. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5410468 Mon, 14 Nov 2011 05:00:00 +0100 5410468 http://www.medworm.com/index.php?rid=5410467&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24027 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5410467 Mon, 14 Nov 2011 05:00:00 +0100 5410467 http://www.medworm.com/index.php?rid=5401671&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23879 Conclusions:In adult Friedreich's ataxia patients the Scale for the Assessment and Rating of Ataxia can detect annual changes independently of disease severity. In future therapeutic trials no patient stratification is globally required. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5401671 Thu, 10 Nov 2011 05:00:00 +0100 5401671 http://www.medworm.com/index.php?rid=5401670&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24018 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5401670 Thu, 10 Nov 2011 05:00:00 +0100 5401670 http://www.medworm.com/index.php?rid=5401669&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24017 In this study, the functional relevance of this structural abnormality was explored using functional magnetic resonance imaging. Ten dyskinetic PD patients and 10 nondyskinetic PD patients were studied in the OFF phase with functional magnetic resonance imaging while performing externally and internally triggered visuomotor tasks. Although neither group demonstrated behavioral differences during execution of motor tasks, magnetic resonance imaging analysis detected significant changes in target cortical regions. In particular, PD patients with levodopa‐induced dyskinesia showed significant overactivity in the supplementary motor area and underactivity in the right inferior prefrontal gyrus during execution of both tasks when compared with PD patients without levodopa‐induced dyskinesia... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5401669 Thu, 10 Nov 2011 05:00:00 +0100 5401669 http://www.medworm.com/index.php?rid=5495971&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24041 AbstractParkinson's disease is heterogeneous, both in terms of motor symptoms and mood. Identifying associations between phenotypic variants of motor and mood subtypes may provide clues to understand mechanisms underlying mood disorder and symptoms in Parkinson's disease. A total of 513 patients were assessed using the Hospital Anxiety and Depression Scale, and separately classified into anxious, depressed, and anxious‐depressed mood classes based on latent class analysis of a semistructured interview. Motor subtypes assessed related to age‐of‐onset, rate of progression, presence of motor fluctuations, lateralization of motor symptoms, tremor dominance, and the presence of postural instability and gait symptoms and falls. The directions of observed associations tended to support prev... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5495971 Tue, 01 Nov 2011 04:00:00 +0100 5495971 http://www.medworm.com/index.php?rid=5488513&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24006 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5488513 Tue, 01 Nov 2011 04:00:00 +0100 5488513 http://www.medworm.com/index.php?rid=5470274&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24023 AbstractImpulse control disorders and related disorders (hobbyism‐punding and dopamine dysregulation syndrome) occur in 15% to 20% of Parkinson's disease (PD) patients. We assessed the validity and reliability of the Questionnaire for Impulsive‐Compulsive Disorders in Parkinson's Disease–Rating Scale (QUIP‐RS), a rating scale designed to measure severity of symptoms and support a diagnosis of impulse control disorders and related disorders in PD. A convenience sample of PD patients at a movement disorders clinic self‐completed the QUIP‐RS and were administered a semistructured diagnostic interview by a blinded trained rater to assess discriminant validity for impulse control disorders (n = 104) and related disorders (n = 77). Subsets of patients were assessed to determine inter... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5470274 Tue, 01 Nov 2011 04:00:00 +0100 5470274 http://www.medworm.com/index.php?rid=5442993&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23849 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5442993 Tue, 01 Nov 2011 04:00:00 +0100 5442993 http://www.medworm.com/index.php?rid=5442992&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23877 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5442992 Tue, 01 Nov 2011 04:00:00 +0100 5442992 http://www.medworm.com/index.php?rid=5442991&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24009 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5442991 Tue, 01 Nov 2011 04:00:00 +0100 5442991 http://www.medworm.com/index.php?rid=5442990&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24036 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5442990 Tue, 01 Nov 2011 04:00:00 +0100 5442990 http://www.medworm.com/index.php?rid=5442986&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23899 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5442986 Tue, 01 Nov 2011 04:00:00 +0100 5442986 http://www.medworm.com/index.php?rid=5365453&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23977 In this study (1) we defined the patients' experience of sensitivity to external stimuli in detail, and (2) we tested 2 hypotheses regarding its origin. First, we interviewed in depth and administered a lengthy questionnaire to adult Tourette patients (n = 19) and age‐matched healthy volunteers (n = 19). Eighty percent of patients described heightened sensitivity to external stimuli, with examples among all 5 sensory modalities. Bothersome stimuli were characterized as faint, repetitive or constant, and nonsalient, whereas intense stimuli were well tolerated. We then determined whether the sensitivity could be the result of an increased ability to detect faint stimuli. After measuring the threshold of detection for olfactory and tactile stimuli among the patients and healthy volunteers, ... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5365453 Fri, 28 Oct 2011 04:00:00 +0100 5365453 http://www.medworm.com/index.php?rid=5365452&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23968 AbstractBackground and objective.Mutations in the Leucine‐Rich Repeat Kinase 2 (LRRK2) gene at chromosome 12q12 are the most common genetic cause of sporadic and familial late‐onset Parkinson's disease. Our aim was to identify novel LRRK2 mutations in late‐onset Parkinson's disease families.Design.We analyzed chromosome 12p11.2‐q13.1 haplotypes in 14 late‐onset Parkinson's disease families without known LRRK2 mutations.Results.Haplotype analysis identified 12 families in which the affected subjects shared chromosome 12p11.2‐q13.1 haplotypes. LRRK2 sequencing revealed a novel co‐segregating missense mutation in exon 36 (c.5281A>C; p.S1761R) located within a highly conserved region of the COR [C‐terminal of ROC (Ras of complex proteins)] domain wherein it could deregulate ... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5365452 Fri, 28 Oct 2011 04:00:00 +0100 5365452 http://www.medworm.com/index.php?rid=5365451&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24020 Conclusions:Exome sequencing is a valuable diagnostic tool in the neuroacanthocytosis syndromes. These studies may provide a better understanding of the function of the associated proteins and provide insight into the pathogenesis of these disorders. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5365451 Fri, 28 Oct 2011 04:00:00 +0100 5365451 http://www.medworm.com/index.php?rid=5365450&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24004 AbstractThe pathology of essential tremor is increasingly being studied; however, there are limited studies of biochemical changes in this condition. We studied several candidate biochemical/anatomical systems in the brain stem, striatum, and cerebellum of 23 essential tremor subjects who came to autopsy, comparing them with a control population. Striatal tyrosine hydroxylase, a marker of dopaminergic neurons, was 91.7 ± 113.2 versus 96.4 ± 102.7 ng/mg (not significant) in cases and controls, respectively. Locus coeruleus dopamine beta‐hydroxylase, a marker of noradrenergic neurons, was not significantly different between the essential tremor and control groups. Parvalbumin, a marker of GABAergic neurons, was 199.3 ± 42.0 versus 251.4 ± 74.8 ng/mg (P = .025) in the pons in the region... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5365450 Fri, 28 Oct 2011 04:00:00 +0100 5365450 http://www.medworm.com/index.php?rid=5365449&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24003 AbstractThe purpose of this study was to determine whether dementia with Lewy bodies with and without probable rapid eye movement sleep behavior disorder differ clinically or pathologically. Patients with dementia with Lewy bodies (DLB) with probable rapid eye movement sleep behavior sleep disorder (n = 71) were compared with those without it (n = 19) on demographics, clinical variables (core features of dementia with Lewy bodies, dementia duration, rate of cognitive/motor changes), and pathologic indices (Lewy body distribution, neuritic plaque score, Braak neurofibrillary tangle stage). Individuals with probable rapid eye movement sleep behavior disorder were predominantly male (82% vs 47%) and had a shorter duration of dementia (mean, 8 vs 10 years), earlier onset of parkinsonism (mean,... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5365449 Fri, 28 Oct 2011 04:00:00 +0100 5365449 http://www.medworm.com/index.php?rid=5365448&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23976 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5365448 Fri, 28 Oct 2011 04:00:00 +0100 5365448 http://www.medworm.com/index.php?rid=5365447&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23974 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5365447 Fri, 28 Oct 2011 04:00:00 +0100 5365447 http://www.medworm.com/index.php?rid=5349726&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23988 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5349726 Mon, 24 Oct 2011 04:00:00 +0100 5349726 http://www.medworm.com/index.php?rid=5349725&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23911 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5349725 Mon, 24 Oct 2011 04:00:00 +0100 5349725 http://www.medworm.com/index.php?rid=5349724&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23910 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5349724 Mon, 24 Oct 2011 04:00:00 +0100 5349724 http://www.medworm.com/index.php?rid=5349723&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23909 Conclusions:Whereas genetic factors are likely to play a large role in essential tremor pathogenesis, our results do not support a role for common SNCA genetic variants in risk for essential tremor. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5349723 Mon, 24 Oct 2011 04:00:00 +0100 5349723 http://www.medworm.com/index.php?rid=5349722&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23908 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5349722 Mon, 24 Oct 2011 04:00:00 +0100 5349722 http://www.medworm.com/index.php?rid=5338150&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24015 AbstractFreezing of gait (FOG) is an incapacitating problem in Parkinson's disease that is difficult to manage therapeutically. We tested the hypothesis that impaired rhythm and amplitude control is a common mechanism of freezing which is also present during other rhythmic tasks. Therefore, we compared the occurrence and spatiotemporal profiles of freezing episodes during upper limb motion, lower limb motion, and FOG. Eleven freezers, 12 non‐freezers, and 11 controls performed a rhythmic bilateral finger movement task. The triggering effect of movement speed, amplitude, and coordination pattern was evaluated. Regression slopes and spectral analysis addressed the spatial and temporal kinematic changes inherent to freezing episodes. The FOG Questionnaire score significantly predicted sever... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5338150 Fri, 21 Oct 2011 04:00:00 +0100 5338150 http://www.medworm.com/index.php?rid=5316891&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23990 AbstractFreezing of gait in Parkinson's disease can be difficult to study in the laboratory. Here we investigate the use of a variable‐width doorway to provoke freeze behavior together with new objective methods to measure it. With this approach we compare the effects of anti‐parkinsonian treatments (medications and deep‐brain stimulation of the subthalamic nucleus) on freezing and other gait impairments. Ten “freezers” and 10 control participants were studied. Whole‐body kinematics were measured while participants walked at preferred speed in each of 4 doorway conditions (no door present, door width at 100%, 125%, and 150% of shoulder width) and in 4 treatment states (offmeds/offstim, offmeds/onstim, onmeds/offstim, onmeds/onstim). With no doorway, the Parkinson's group showed... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5316891 Thu, 13 Oct 2011 04:00:00 +0100 5316891 http://www.medworm.com/index.php?rid=5316890&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23953 This article reviews some of the more common pharmacologic treatments used for HD, discusses data regarding suboptimal agents that have been tested, and surveys treatments under investigation. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5316890 Thu, 13 Oct 2011 04:00:00 +0100 5316890 http://www.medworm.com/index.php?rid=5316889&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23967 AbstractDeep brain stimulation has been used as a means of reducing dyskinesias in various conditions, including Parkinson's disease and dystonia for many years. Recently, owing to the clinical similarities between L‐dopa induced dyskinesia and chorea, deep brain stimulation has now been implemented as a novel treatment method in both Huntington's disease and neuroacanthocytosis, and a paucity of case studies exist reporting its efficacy. This review will summarize the case studies of deep brain stimulation in both Huntington's disease and neuroacanthocytosis, and discuss the possible implications and limitations associated with these reports. As both these disorders are often refractory to medication and difficult to treat, deep brain stimulation may be a useful treatment option in the ... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5316889 Thu, 13 Oct 2011 04:00:00 +0100 5316889 http://www.medworm.com/index.php?rid=5316888&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23930 In this study we describe clinical, electromyographic (EMG), and radiological features of PS in a group of 20 PD patients. All patients with trunk deviation underwent EMG and radiological (RX and CT scan) investigation. Clinical characteristics of patients with PS were compared with a control group of PD patients without trunk deviation. PD patients with PS showed a significantly higher score of disease asymmetry compared with the control group. In the majority of patients with PS, trunk bending was contralateral to the side of symptom onset. EMG showed abnormal tonic hyperactivity on the side of the deviation in the paravertebral thoracic muscles and in the abdominal oblique muscles. CT of the lumbar paraspinal muscles showed muscular atrophy more marked on the side of the deviation, with... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5316888 Thu, 13 Oct 2011 04:00:00 +0100 5316888 http://www.medworm.com/index.php?rid=5316895&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23886 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5316895 Wed, 12 Oct 2011 04:00:00 +0100 5316895 http://www.medworm.com/index.php?rid=5316894&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24007 The objective of this study was to establish whether a relation between handedness and dominant PD side exists. We searched for cross‐sectional or cohort studies that registered handedness and onset side in PD patients in PubMed, EMBASE, and Web of Science from their first record until 14 February 2011. Data about handedness and dominant PD side was extracted. Authors who registered both but not described their relation were contacted for further information. Odds ratios (ORs) were analyzed with a fixed effect Mantel‐Haenszel model. Heterogeneity and indications of publication bias were limited. Our electronic search identified 10 studies involving 4405 asymmetric PD patients. Of the right‐handed patients, 2413 (59.5%) had right‐dominant and 1644 (40.5%) had left‐dominant PD symp... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5316894 Wed, 12 Oct 2011 04:00:00 +0100 5316894 http://www.medworm.com/index.php?rid=5316893&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23895 The objective of the present study was to use positron emission tomography and [18F]MPPF to investigate the role of postsynaptic serotonergic system dysfunction in the pathophysiology of depression in Parkinson's disease. Four parkinsonian patients with depression and 8 parkinsonian patients without depression were enrolled. Each patient underwent a scan using [18F]MPPF, a selective serotonin 1A receptor antagonist. Voxel‐by‐voxel statistical comparison of [18F]MPPF uptake of the 2 groups of parkinsonian patients and with 7 matched normal subjects was made using statistical parametric mapping (P uncorrected < .001). Compared with nondepressed parkinsonian patients, depressed patients exhibited reduced tracer uptake in the left hippocampus, the right insula, the left superior tempora... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5316893 Wed, 12 Oct 2011 04:00:00 +0100 5316893 http://www.medworm.com/index.php?rid=5316892&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23969 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5316892 Wed, 12 Oct 2011 04:00:00 +0100 5316892 http://www.medworm.com/index.php?rid=5305955&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23935 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5305955 Tue, 11 Oct 2011 04:00:00 +0100 5305955 http://www.medworm.com/index.php?rid=5305956&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23904 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5305956 Mon, 10 Oct 2011 04:00:00 +0100 5305956 http://www.medworm.com/index.php?rid=5287495&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23868 AbstractImpairment of executive function (EF) is commonly reported as a feature of PD. However, the exact pattern of executive impairment remains unclear. Also, there is an ongoing discussion surrounding the definition and conceptualization of EF, which might affect the clarity of research evidence on cognition in PD. The aim of this systematic review was to describe the pattern of executive impairment in early‐stage PD emerging from the research literature and to identify critical issues for improving consistency in this field. The PsychInfo, MEDLINE, Science Direct, CINAHL, and Cochrane Library databases were searched using the term “Parkinson's disease” combined with each of 14 cognitive abilities defined as representing aspects of EF. The review was limited to studies that invest... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5287495 Mon, 03 Oct 2011 04:00:00 +0100 5287495 http://www.medworm.com/index.php?rid=5423727&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24029 Conclusions:This study suggests a possible role of NAGLU in susceptibility to PD while extending evidence for α‐synuclein aggregation in the brain in lysosomal storage disorders. Our findings support a mechanism involving lysosomal dysfunction more generally in the pathogenesis of PD. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5423727 Sat, 01 Oct 2011 04:00:00 +0100 5423727 http://www.medworm.com/index.php?rid=5410465&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24012 Conclusions:These observations parallel those well established for active smoking. However, it remains unresolved whether a true protective effect of tobacco smoke, generally detrimental to health, underlies these associations. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5410465 Sat, 01 Oct 2011 04:00:00 +0100 5410465 http://www.medworm.com/index.php?rid=5401668&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23795 AbstractParkinson's disease (PD), one of the most frequent neurodegenerative disorders, is no longer considered a complex motor disorder characterized by extrapyramidal symptoms, but a progressive multisystem or—more correctly—multiorgan disease with variegated neurological and nonmotor deficiencies. It is morphologically featured not only by the degeneration of the dopaminergic nigrostriatal system, responsible for the core motor deficits, but by multifocal involvement of the central, peripheral and autonomic nervous system and other organs associated with widespread occurrence of Lewy bodies and dystrophic Lewy neurites. This results from deposition of abnormal α‐synuclein (αSyn), the major protein marker of PD, and other synucleinopathies. Recent research has improved both the c... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5401668 Sat, 01 Oct 2011 04:00:00 +0100 5401668 http://www.medworm.com/index.php?rid=5365446&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23982 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5365446 Sat, 01 Oct 2011 04:00:00 +0100 5365446 http://www.medworm.com/index.php?rid=5349721&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23971 AbstractIn recent years, understanding of the syndromes of neurodegeneration with brain iron accumulation (NBIA) has grown considerably. In addition to the core syndromes of pantothenate kinsase–associated neurodegeneration (PKAN, NBIA1) and PLA2G6‐associated neurodegeneration (PLAN, NBIA2), several other genetic causes have been identified. The acknowledged clinical spectrum has broadened, age‐dependent presentations have been recognized, and we are becoming aware of overlap between the different NBIA disorders as well as with other diseases. Autopsy examination of genetically confirmed cases has demonstrated Lewy bodies and/or tangles in some subforms, bridging the gap to more common neurodegenerative disorders such as Parkinson's disease. NBIA genes map into related pathways, the ... Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5349721 Sat, 01 Oct 2011 04:00:00 +0100 5349721 http://www.medworm.com/index.php?rid=5338157&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23878 Conclusions:There will be a strong increase in the number of people affected by most movement disorders between 2010 and 2050. This increase will mostly depend on the future aging of populations in terms of their age structure and future life expectancy. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5338157 Sat, 01 Oct 2011 04:00:00 +0100 5338157 http://www.medworm.com/index.php?rid=5338156&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23876 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5338156 Sat, 01 Oct 2011 04:00:00 +0100 5338156 http://www.medworm.com/index.php?rid=5338155&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.24008 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5338155 Sat, 01 Oct 2011 04:00:00 +0100 5338155 http://www.medworm.com/index.php?rid=5338154&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23979 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5338154 Sat, 01 Oct 2011 04:00:00 +0100 5338154 http://www.medworm.com/index.php?rid=5338153&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23985 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5338153 Sat, 01 Oct 2011 04:00:00 +0100 5338153 http://www.medworm.com/index.php?rid=5338152&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23980 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5338152 Sat, 01 Oct 2011 04:00:00 +0100 5338152 http://www.medworm.com/index.php?rid=5338151&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23996 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5338151 Sat, 01 Oct 2011 04:00:00 +0100 5338151 http://www.medworm.com/index.php?rid=5338149&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23984 Conclusions:These results suggest that abnormalities of fatty acid metabolism are specifically involved in the pathogenesis of Parkinson's disease associated with a heterozygous glucocerebrosidase mutation. © 2011 Movement Disorder Society (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5338149 Sat, 01 Oct 2011 04:00:00 +0100 5338149 http://www.medworm.com/index.php?rid=5262613&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23962 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5262613 Wed, 28 Sep 2011 04:00:00 +0100 5262613 http://www.medworm.com/index.php?rid=5262612&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23874 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5262612 Wed, 28 Sep 2011 04:00:00 +0100 5262612 http://www.medworm.com/index.php?rid=5262611&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23960 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5262611 Wed, 28 Sep 2011 04:00:00 +0100 5262611 http://www.medworm.com/index.php?rid=5262610&cid=s_33605_25_f&fid=33605&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmds.23957 (Source: Movement Disorders) Movement Disorders journals http://www.medworm.com/rss/comments.php?id=5262610 Wed, 28 Sep 2011 04:00:00 +0100 5262610