MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Multiple Sclerosis' source. Wed, 08 Feb 2012 20:43:25 +0100 http://www.medworm.com/index.php?rid=5668786&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F18%2F2%2F254%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668786 Mon, 06 Feb 2012 05:00:00 +0100 5668786 http://www.medworm.com/index.php?rid=5668785&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F18%2F2%2F252%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668785 Mon, 06 Feb 2012 05:00:00 +0100 5668785 http://www.medworm.com/index.php?rid=5668784&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F18%2F2%2F250%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668784 Mon, 06 Feb 2012 05:00:00 +0100 5668784 http://www.medworm.com/index.php?rid=5668783&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F18%2F2%2F248%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668783 Mon, 06 Feb 2012 05:00:00 +0100 5668783 http://www.medworm.com/index.php?rid=5668782&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F244%3Frss%3D1 We present a cortical oscillopsia without nystagmus or head tremor in a patient with neuromyelitis optica spectrum disorder (NMOSD) with anti-aquaporin 4 antibody. This rare ocular manifestation, which is easily underestimated owing to absence of the typical nystagmus, can be an initial manifestation of NMOSD. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668782 Mon, 06 Feb 2012 05:00:00 +0100 5668782 http://www.medworm.com/index.php?rid=5668781&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F240%3Frss%3D1 Neuromyelitis optica (NMO) is an idiopathic demyelinating disease which predominantly affects the optic nerve and spinal cord. Multiplex NMO pedigrees have been reported but the genetic risk factors conferring this increased familial susceptibility have not yet been determined. OPA1 mutations have recently been identified in families with progressive visual failure and spastic paraparesis, raising the possibility that OPA1 genetic variants could contribute to the aetiology of NMO. We therefore screened for OPA1 in 32 patients with NMO. No pathogenic mutations were found, and none of the 13 single-nucleotide polymorphisms identified were associated with an increased risk of developing NMO. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668781 Mon, 06 Feb 2012 05:00:00 +0100 5668781 http://www.medworm.com/index.php?rid=5668780&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F236%3Frss%3D1 Interferon-β (IFN-β) stabilizes the blood–brain barrier (BBB) in vitro. Here we investigated the effect of serum from 15 IFN-β-1b-treated multiple sclerosis (MS) patients on the permeability read-outs of small solutes in an in vitro BBB model consisting of human brain microvascular endothelial cells in co-culture with rat astrocytes. The addition of sera from IFN-β-treated patients resulted in a significantly (p < 0.05) reduced permeability as compared with untreated patients. Our findings show that sera from IFN-β-1b-treated MS patients have a stabilizing effect on the in vitro BBB. We suggest an unknown potentially pro-inflammatory factor in the serum of MS patients that may lead to a BBB dysfunction and can be modulated by IFN-β. (Source: Multiple ... Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668780 Mon, 06 Feb 2012 05:00:00 +0100 5668780 http://www.medworm.com/index.php?rid=5668779&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F232%3Frss%3D1 Since multiple sclerosis (MS) often affects physically active young individuals, it is important to know if exercise can result in increased disease activity. Therefore we used a self-report questionnaire to examine the relationship of different levels of sports activity and relapses in 632 patients with MS. In order to analyse whether subjective recall might have biased the results, we performed, in a subgroup of our sample, an objective assessment of clinical data and physical fitness parameters. We were unable to find any association between sports activity and clinical relapses in either of the two analyses. The group with highest activity even shows the lowermost mean values, standard deviations and range concerning the number of relapses. Our data suggest that physical activity has n... Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668779 Mon, 06 Feb 2012 05:00:00 +0100 5668779 http://www.medworm.com/index.php?rid=5668778&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F229%3Frss%3D1 Recent studies have shown the relevance of the cerebral grey matter involvement in multiple sclerosis (MS). Cortical lesions (CLs), detected by specific MRI sequences, are likely to become a new research outcome in MS studies. The aim of this study was to infer the optimal statistical model describing the distribution of CLs in patients with relapsing–remitting (RR)MS. The negative binomial model gave the best fit to the observed distribution of CLs in a group of 44 RRMS patients with one MRI scan of the brain. This observation has important implications for the statistical analysis of CLs in MS studies. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668778 Mon, 06 Feb 2012 05:00:00 +0100 5668778 http://www.medworm.com/index.php?rid=5668777&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F219%3Frss%3D1 Conclusions: Maintenance of Sativex efficacy in long-term symptomatic improvement of spasticity to a group of subjects with MS has been confirmed using this study design. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668777 Mon, 06 Feb 2012 05:00:00 +0100 5668777 http://www.medworm.com/index.php?rid=5668776&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F210%3Frss%3D1 Conclusions: Currently accepted criteria for BMS diagnosis may cause overestimation of true prevalence, underscoring the need for routine monitoring of non-motor symptoms and imaging studies, to help physicians improve diagnostic accuracy as well as therapeutic decision-making in this subgroup of MS patients. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668776 Mon, 06 Feb 2012 05:00:00 +0100 5668776 http://www.medworm.com/index.php?rid=5668775&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F202%3Frss%3D1 Conclusions: Induction therapy with HiCy followed by long-term maintenance with glatiramer acetate is well tolerated in patients with MS, and appears to be efficacious in reducing the risk of relapse, disability progression, and new MRI lesions. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668775 Mon, 06 Feb 2012 05:00:00 +0100 5668775 http://www.medworm.com/index.php?rid=5668774&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F196%3Frss%3D1 Conclusion: Partners of patients with MS can be a useful source of information for several PRO scales, especially when the focus is on physical functioning. For psychological functioning this seems to be less reliable. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668774 Mon, 06 Feb 2012 05:00:00 +0100 5668774 http://www.medworm.com/index.php?rid=5668773&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F181%3Frss%3D1 Conclusion: There was a notable dissociation between the impact of NAbs on MRI and clinical outcomes. On MRI measures, the impact was consistent and convincing, whereas on clinical measures a negative impact of NAbs was not found. The basis for this clinico-radiographic paradox is unknown but it suggests that the relationship between NAbs and the therapeutic effects of IFNβ-1b is complex. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668773 Mon, 06 Feb 2012 05:00:00 +0100 5668773 http://www.medworm.com/index.php?rid=5668772&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F174%3Frss%3D1 Conclusion: We observed that the association of intrathecal immunoglobulin synthesis and CLs was highly predictive of an earlier CIS conversion to MS as well as of a higher disease activity. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668772 Mon, 06 Feb 2012 05:00:00 +0100 5668772 http://www.medworm.com/index.php?rid=5668771&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F164%3Frss%3D1 Conclusions: Functional connectivity differences were found in male patients only and were related to impaired visuospatial memory. These results underline the importance of gender in MS and require further investigation in larger and longitudinal studies. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668771 Mon, 06 Feb 2012 05:00:00 +0100 5668771 http://www.medworm.com/index.php?rid=5668770&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F153%3Frss%3D1 Conclusions: During performance of the PASAT, CIS patients show abnormalities in the patterns of cortical recruitment and connectivity related to the level of their cognitive impairment. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668770 Mon, 06 Feb 2012 05:00:00 +0100 5668770 http://www.medworm.com/index.php?rid=5668769&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F143%3Frss%3D1 Natalizumab is a highly effective immunomodulator in the treatment of multiple sclerosis (MS). Treatment with natalizumab has been associated with progressive multifocal leukoencephalopathy (PML), an infection of the central nervous system (CNS) caused by a pathogenic form of the normally benign JC virus (JCV). We searched PubMed and used current data from the natalizumab global safety database to assess risk factors and quantify the risk of PML. Natalizumab treatment duration and prior use of immunosuppressive therapies are established risk factors for development of PML in natalizumab-treated patients. With the development of a reliable and validated assay for detection of antibodies in patients with MS directed against JCV, it is now possible to identify persons who are carriers of JCV.... Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668769 Mon, 06 Feb 2012 05:00:00 +0100 5668769 http://www.medworm.com/index.php?rid=5668768&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F18%2F2%2F142%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668768 Mon, 06 Feb 2012 05:00:00 +0100 5668768 http://www.medworm.com/index.php?rid=5668767&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F18%2F2%2F140%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668767 Mon, 06 Feb 2012 05:00:00 +0100 5668767 http://www.medworm.com/index.php?rid=5668766&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F18%2F2%2F138%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668766 Mon, 06 Feb 2012 05:00:00 +0100 5668766 http://www.medworm.com/index.php?rid=5668765&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F2%2F133%3Frss%3D1 How axonal damage, a major prognostic factor of multiple sclerosis disability progression, is induced, is likely to be multifactorial. Whereas axonal injury has been identified as a consequence of myelin loss, the possibility of an additional direct damage is also suggested. In this context, recent data have highlighted the nodal and perinodal axonal domains of the myelinated neurons as potential targets of the disease process, opening new perspectives in multiple sclerosis pathophysiology. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668765 Mon, 06 Feb 2012 05:00:00 +0100 5668765 http://www.medworm.com/index.php?rid=5668764&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F18%2F2%2F131%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5668764 Mon, 06 Feb 2012 05:00:00 +0100 5668764 http://www.medworm.com/index.php?rid=5584783&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F116%3Frss%3D1 New therapies are being evaluated by clinical trials and, if efficacious, introduced for the treatment of adult MS. The role of these new and existing agents in the management of pediatric MS has yet to be defined. Pediatric investigation plans are now required by the Food and Drug Administration and European Medicines Agency for approval of new biological agents, providing an important opportunity to gather much-needed data for clinicians caring for children and adolescents with MS. However, challenges include the small number of patients, and the need for efficient yet comprehensive study designs incorporating factors necessary to inform the clinical care of children with MS. The elected Steering committee of the International Pediatric MS Study Group (IPMSSG) conducted a structured revi... Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584783 Fri, 13 Jan 2012 05:00:00 +0100 5584783 http://www.medworm.com/index.php?rid=5584782&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F113%3Frss%3D1 We report the case of a patient who developed extensive brain lesions during fingolimod (FTY720) treatment in the TRANSFORMS study. His initial diagnosis was multiple sclerosis, but after encephalopathy anti-aquaporin4 antibody (anti-AQP4 Ab) was detected, it was changed to neuromyelitis optica spectrum disorder. After treatment with fingolimod, he developed bilateral extensive brain lesions. The brain MRI showed lesions predominantly involving the right frontal and parietal lobes, with vasogenic edema and enhancement. He had residual encephalomalacia and no recurrence with steroid treatment over 3 years following withdrawal of fingolimod. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584782 Fri, 13 Jan 2012 05:00:00 +0100 5584782 http://www.medworm.com/index.php?rid=5584781&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F108%3Frss%3D1 We describe the clinical, radiological and neuropathological features of a severe cerebral attack in a natalizumab-treated patient with relapsing myelitis and serum aquaporin-4 antibodies. Our findings support autopsy evidence that abrupt astrocyte destruction precedes demyelination in NMO, and emphasize the importance of serological testing in patients with limited disease. Adherence to current NMO diagnostic criteria may delay treatment, or lead to inappropriate therapy with beta-interferon or natalizumab. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584781 Fri, 13 Jan 2012 05:00:00 +0100 5584781 http://www.medworm.com/index.php?rid=5584780&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F98%3Frss%3D1 Conclusion: Since the WBNAA loss rate is similar in both phenotypes, the only difference between them is their clinical classification, characterized by MSSS and EDSS. This may indicate that ‘benign’ MS probably reflects fortuitous sparing of clinically eloquent brain regions and better utilization of brain plasticity. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584780 Fri, 13 Jan 2012 05:00:00 +0100 5584780 http://www.medworm.com/index.php?rid=5584779&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F90%3Frss%3D1 Conclusions: Using a large, cohort of women-nurses, history of migraine was associated with an increased risk of MS. However, the difference in absolute risk of MS in migraineurs and non-migraineurs was small. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584779 Fri, 13 Jan 2012 05:00:00 +0100 5584779 http://www.medworm.com/index.php?rid=5584778&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F82%3Frss%3D1 Conclusions: Exposure to a low frequency magnetic field, within the parameters of this treatment protocol, has no advantage over sham exposure in reducing the impact of fatigue. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584778 Fri, 13 Jan 2012 05:00:00 +0100 5584778 http://www.medworm.com/index.php?rid=5584777&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F72%3Frss%3D1 Conclusion: This study provides Class I evidence that simvastatin 80 mg daily is well tolerated and possibly effective in patients with acute ON. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584777 Fri, 13 Jan 2012 05:00:00 +0100 5584777 http://www.medworm.com/index.php?rid=5584776&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F64%3Frss%3D1 Conclusion: We suggest that an escalation to natalizumab is more effective than switching among immunomodulators in RRMS patients who failed a first-line treatment. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584776 Fri, 13 Jan 2012 05:00:00 +0100 5584776 http://www.medworm.com/index.php?rid=5584775&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F55%3Frss%3D1 Conclusion: We found no evidence of an increased risk of cancer associated with cyclophosphamide treatment in MS patients. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584775 Fri, 13 Jan 2012 05:00:00 +0100 5584775 http://www.medworm.com/index.php?rid=5584774&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F45%3Frss%3D1 Conclusions: Age at disease onset in RRMS exerts a significant effect on gender ratios and presenting phenotype, and allows identification of specific clinical sub-groups. In addition, ability to recover from initial relapse declines with age, suggesting accumulation of disability in MS is an age-dependent response to relapse. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584774 Fri, 13 Jan 2012 05:00:00 +0100 5584774 http://www.medworm.com/index.php?rid=5584773&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F39%3Frss%3D1 Conclusion: New DIS criteria are simpler and more sensitive than previous criteria. The sensitivity of DIT criterion using a single MRI scan was rather low, as other previous studies showed, reflecting its stringency, but it could improve the accuracy of early MS diagnosis in that group of patients with typical CIS and gadolinium-enhancing and non-enhancing lesions on their baseline scans. These results reinforce their use in MS diagnosis. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584773 Fri, 13 Jan 2012 05:00:00 +0100 5584773 http://www.medworm.com/index.php?rid=5584772&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F31%3Frss%3D1 Conclusion: Combined EPs allow prediction of long-term disability in small groups of patients with MS. This may have implications for the choice of monitoring methods in clinical trials and for daily practice decisions. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584772 Fri, 13 Jan 2012 05:00:00 +0100 5584772 http://www.medworm.com/index.php?rid=5584771&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F23%3Frss%3D1 Conclusion: Patients with NMO had frequent co-existence of autoimmunity and family occurrence of NMO and MS. The PD-1.3A allele was associated with NMO. The data suggest genetic autoimmune dependency of NMO. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584771 Fri, 13 Jan 2012 05:00:00 +0100 5584771 http://www.medworm.com/index.php?rid=5584770&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F16%3Frss%3D1 Conclusion: We have identified weak evidence of an association between a common variation within the VDR gene and MS, in the largest study reported to date of this candidate gene. There appears to be a relationship between polymorphisms in the VDR and the risk of MS, which is potentially modified by HLA-DRB1*1501. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584770 Fri, 13 Jan 2012 05:00:00 +0100 5584770 http://www.medworm.com/index.php?rid=5584769&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F18%2F1%2F15%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584769 Fri, 13 Jan 2012 05:00:00 +0100 5584769 http://www.medworm.com/index.php?rid=5584768&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F18%2F1%2F13%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584768 Fri, 13 Jan 2012 05:00:00 +0100 5584768 http://www.medworm.com/index.php?rid=5584767&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F18%2F1%2F11%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584767 Fri, 13 Jan 2012 05:00:00 +0100 5584767 http://www.medworm.com/index.php?rid=5584766&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F18%2F1%2F5%3Frss%3D1 We describe the historical background of this controversy, summarize the current evidence that addresses NMO–systemic autoimmunity relationships, and discuss the practical implications for clinical management. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584766 Fri, 13 Jan 2012 05:00:00 +0100 5584766 http://www.medworm.com/index.php?rid=5584765&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F18%2F1%2F2%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584765 Fri, 13 Jan 2012 05:00:00 +0100 5584765 http://www.medworm.com/index.php?rid=5584764&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F18%2F1%2F1%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5584764 Fri, 13 Jan 2012 05:00:00 +0100 5584764 http://www.medworm.com/index.php?rid=5459672&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1539%3Frss%3D1 to, Mowry EM, James JA, Krupp LB and Waubant E. Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis. Multiple Sclerosis Journal (2011) 17(6) 666-671 [DOI: 10.1177/1352458511394398]. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459672 Wed, 30 Nov 2011 05:00:00 +0100 5459672 http://www.medworm.com/index.php?rid=5459671&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1531%3Frss%3D1 We report a case of a 31-year-old woman with Marburg’s variant of MS who, over a period of eight months, became totally disabled, blind, and quadriplegic, with vocal cord paralysis, requiring a tracheostomy. The patient underwent diagnostic stereotactic brain biopsy. Clinical findings, magnetic resonance imaging (MRI), serologic and cerebrospinal fluid (CSF) findings, and neuropathology are discussed. MRI showed extensive white matter involvement in the brain and spinal cord that continuously progressed over time. A diagnostic stereotactic brain biopsy revealed extensive active demyelination with unexpected finding of active vasculitis and fibrinoid necrosis with a vascular inflammatory cell infiltrate, including polymorphonuclear neutrophils and rare eosinophils. Serologic work-up f... Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459671 Wed, 30 Nov 2011 05:00:00 +0100 5459671 http://www.medworm.com/index.php?rid=5459670&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1527%3Frss%3D1 The detection of antibodies against aquaporin-4 (AQP4) has improved the diagnosis of neuromyelitis optica (NMO). We evaluated a recently established cell-based anti-AQP4 assay in 273 patients with inflammatory CNS demyelination. The assay had a specificity of 99% and a sensitivity of 56% to detect all NMO patients and of 74% to detect the recurrent NMO patients, similar to the initial studies reported. AQP4 antibodies were absent in monophasic NMO patients, while samples in recurrent cases remained positive during follow-up. We conclude that the pathogenesis of monophasic NMO may be different from that of relapsing NMO. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459670 Wed, 30 Nov 2011 05:00:00 +0100 5459670 http://www.medworm.com/index.php?rid=5459669&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1523%3Frss%3D1 This study examined the safety and efficacy of an escalating dose (100 mg, 200 mg, 400 mg/day) of American ginseng over 6 weeks in a single-center, randomized, double-blind, placebo-controlled, crossover trial with 56 subjects with multiple sclerosis and fatigue. There were no serious adverse events but fatigue on ginseng, as assessed by the Fatigue Severity Scale, was not significantly different from fatigue on placebo. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459669 Wed, 30 Nov 2011 05:00:00 +0100 5459669 http://www.medworm.com/index.php?rid=5459668&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1520%3Frss%3D1 We report the case of a young woman with multiple sclerosis who discontinued natalizumab twice and experienced a severe relapse following each natalizumab withdrawal. The first relapse was successfully treated by intravenous methylprednisolone (IVMP). In contrast the second relapse was unresponsive to IVMP. Subsequent treatment by plasma exchanges (PLEX) was followed by a dramatic neurological worsening. This case suggests that PLEX after natalizumab discontinuation may increase relapse severity. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459668 Wed, 30 Nov 2011 05:00:00 +0100 5459668 http://www.medworm.com/index.php?rid=5459667&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1514%3Frss%3D1 Conclusions: PTNS is an effective, safe and well-tolerated treatment for LUTS in patients with MS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459667 Wed, 30 Nov 2011 05:00:00 +0100 5459667 http://www.medworm.com/index.php?rid=5459666&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1504%3Frss%3D1 Conclusions: In trials involving patients with early stage RRMS and CIS, modifications to the FAMS based on a qualitative assessment of its content validity in these populations would be required in order to potentially improve the FAMS psychometric properties and sensitivity. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459666 Wed, 30 Nov 2011 05:00:00 +0100 5459666 http://www.medworm.com/index.php?rid=5459665&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1498%3Frss%3D1 Conclusion: Results showed a clear factor structure of the GNDS. It justifies the use of the total score of the GNDS. In addition, three sub-scale scores could be used. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459665 Wed, 30 Nov 2011 05:00:00 +0100 5459665 http://www.medworm.com/index.php?rid=5459664&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1488%3Frss%3D1 Conclusions: These findings reveal that the combination of these two learning strategies may possess utility as a cognitive rehabilitation strategy. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459664 Wed, 30 Nov 2011 05:00:00 +0100 5459664 http://www.medworm.com/index.php?rid=5459663&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1472%3Frss%3D1 Conclusions: Our case series and literature review demonstrates an association between TNFAI therapy and inflammatory neurological disease. While a causal relationship is suggested, this remains uncertain. TNFAI-associated neurological syndromes are associated with significant disability and longer follow-up is needed to better determine natural history and evaluate appropriate treatment interventions. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459663 Wed, 30 Nov 2011 05:00:00 +0100 5459663 http://www.medworm.com/index.php?rid=5459662&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1464%3Frss%3D1 Conclusions: Visual and vascular comorbidities are associated with progression of visual disability in MS. Clinicians hearing reports of worsening visual symptoms in MS patients should consider visual comorbidities as contributing factors. Further study of these issues using objective, systematic neuro-ophthalmologic evaluations is warranted. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459662 Wed, 30 Nov 2011 05:00:00 +0100 5459662 http://www.medworm.com/index.php?rid=5459661&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1449%3Frss%3D1 Conclusions: OCT segmentation demonstrates in vivo GCIP thinning in all MS subtypes. GCIP thickness demonstrates better structure-function correlations (with vision and disability) in MS than RNFL thickness. In addition to commonly observed RNFL/GCIP thinning, retinal inner and outer nuclear layer thinning occur in MS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459661 Wed, 30 Nov 2011 05:00:00 +0100 5459661 http://www.medworm.com/index.php?rid=5459660&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1441%3Frss%3D1 Conclusion: CD56bright NK cell expansion after DAC treatment appears to reflect individual differences in the capacity for intermediate-affinity IL-2 signaling and could provide a basis for predicting clinical response to DAC in MS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459660 Wed, 30 Nov 2011 05:00:00 +0100 5459660 http://www.medworm.com/index.php?rid=5459659&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1432%3Frss%3D1 Conclusions: Quantitative MRI measures of diffuse tissue damage such as brain atrophy and NAA/Cr, in addition to measures of focal demyelinating lesions, may predict short-term disease evolution in patients with CIS, particularly when used in combination. If confirmed in larger studies, these findings may have important clinical and therapeutic implications. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459659 Wed, 30 Nov 2011 05:00:00 +0100 5459659 http://www.medworm.com/index.php?rid=5459658&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1424%3Frss%3D1 Conclusions: CSF-TSI lesions characterize patients with more advanced disease and probably contribute to the progress of disability. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459658 Wed, 30 Nov 2011 05:00:00 +0100 5459658 http://www.medworm.com/index.php?rid=5459657&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1418%3Frss%3D1 Conclusion: In patients with MS, supplementation of high doses vitamin D3 does not have substantial effects on phenotypic markers of B cell differentiation in circulating B cells. Future studies may unravel more subtle changes in the B cell compartment, either in the circulation or in the central nervous system. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459657 Wed, 30 Nov 2011 05:00:00 +0100 5459657 http://www.medworm.com/index.php?rid=5459656&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F12%2F1417%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459656 Wed, 30 Nov 2011 05:00:00 +0100 5459656 http://www.medworm.com/index.php?rid=5459655&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F12%2F1415%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459655 Wed, 30 Nov 2011 05:00:00 +0100 5459655 http://www.medworm.com/index.php?rid=5459654&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F12%2F1412%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459654 Wed, 30 Nov 2011 05:00:00 +0100 5459654 http://www.medworm.com/index.php?rid=5459653&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F12%2F1405%3Frss%3D1 Observational studies suggest that adequate vitamin D nutrition may reduce the risk of MS and affect the course of the disease. Inherent limitations in these studies, however, preclude a causal interpretation. Randomized controlled clinical trials are the next step to addressing whether vitamin D prevents MS or can favorably affect the course and progression of MS. Here we briefly review the current literature on vitamin D and MS, both as a risk factor and potential treatment for MS with a focus on the issues and challenges in designing prevention and treatment clinical trials. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459653 Wed, 30 Nov 2011 05:00:00 +0100 5459653 http://www.medworm.com/index.php?rid=5459652&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F12%2F1403%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5459652 Wed, 30 Nov 2011 05:00:00 +0100 5459652 http://www.medworm.com/index.php?rid=5390053&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F11%2F1397%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390053 Fri, 04 Nov 2011 04:00:00 +0100 5390053 http://www.medworm.com/index.php?rid=5390052&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F11%2F1396%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390052 Fri, 04 Nov 2011 04:00:00 +0100 5390052 http://www.medworm.com/index.php?rid=5390051&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F11%2F1395%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390051 Fri, 04 Nov 2011 04:00:00 +0100 5390051 http://www.medworm.com/index.php?rid=5390050&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F11%2F1393%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390050 Fri, 04 Nov 2011 04:00:00 +0100 5390050 http://www.medworm.com/index.php?rid=5390049&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1390%3Frss%3D1 In this study, we look at a 39-year-old woman who received glatiramer acetate as subcutaneous injections for two months and developed contact dermatitis. The drug had to be stopped, and treatment with topical prednisone was initiated. Prick/scratch testing was negative but the lymphocyte transformation test was highly positive for glatiramer acetate. This is the first report on contact dermatitis induced by glatiramer acetate injections. The treatment consisted of local topical steroids and cessation of the drug. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390049 Fri, 04 Nov 2011 04:00:00 +0100 5390049 http://www.medworm.com/index.php?rid=5390048&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1387%3Frss%3D1 We report a patient with MS who developed asystole and sustained bradycardia 21 hours after the first dose of fingolimod. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390048 Fri, 04 Nov 2011 04:00:00 +0100 5390048 http://www.medworm.com/index.php?rid=5390047&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1384%3Frss%3D1 This report, which appeared in 1865, i.e. 15 years prior to Wilhelm Erb’s much-cited paper on the coincidence of optic neuritis and acute myelitis, represents the first known account of a case of Devic’s syndrome or neuromyelitis optica in the English-language medical literature. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390047 Fri, 04 Nov 2011 04:00:00 +0100 5390047 http://www.medworm.com/index.php?rid=5390046&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1375%3Frss%3D1 Conclusions: Despite remaining benign for 20 years, a significant proportion of patients progressed with further follow up. While neither depression nor patient-reported mental health quality of life was associated with EDSS progression, patients with longstanding ‘benign’ MS (EDSS ≤3 for 25+ years) had less fatigue, better physical quality of life and employment outcomes and infrequent cognitive impairment. Remaining benign over the long term, as defined by the EDSS, carried some advantages beyond ambulation. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390046 Fri, 04 Nov 2011 04:00:00 +0100 5390046 http://www.medworm.com/index.php?rid=5390045&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1362%3Frss%3D1 Conclusion: PRT is a relatively safe intervention that can have short-term effects on reducing physical fatigue, increasing muscle endurance and can lead to small improvements in muscle strength and quality of life in people with relapsing–remitting MS. However, no improvements in walking performance were observed and benefits do not appear to persist if training is completely stopped. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390045 Fri, 04 Nov 2011 04:00:00 +0100 5390045 http://www.medworm.com/index.php?rid=5390044&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1351%3Frss%3D1 Conclusion: These preliminary findings suggest that rivastigmine may improve cognitive processing speed by enhancing compensatory brain activation in patients with MS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390044 Fri, 04 Nov 2011 04:00:00 +0100 5390044 http://www.medworm.com/index.php?rid=5390043&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1341%3Frss%3D1 Conclusion: Fingolimod 1.25 mg may improve HRQoL and depression at 6 onths compared with placebo in patients with relapsing MS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390043 Fri, 04 Nov 2011 04:00:00 +0100 5390043 http://www.medworm.com/index.php?rid=5390042&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1333%3Frss%3D1 Conclusion: A single, 12-hour post-injection sample should be used to test for NAbs using the luciferase assay and IFN-β bioactivity (MxA) in the clinical setting. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390042 Fri, 04 Nov 2011 04:00:00 +0100 5390042 http://www.medworm.com/index.php?rid=5390041&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1324%3Frss%3D1 Conclusions: The finding of strong associations between GM MTR, NAWM volume and T2LL and specific cognitive impairments suggests that models that predict cognitive impairment in PPMS should include comprehensive MRI assessments of both GM and WM. However, GM MTR appears to be the main correlate of overall cognitive dysfunction, underlining the role of abnormal GM integrity in determining cognitive impairment in PPMS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390041 Fri, 04 Nov 2011 04:00:00 +0100 5390041 http://www.medworm.com/index.php?rid=5390040&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1313%3Frss%3D1 Conclusions: MRI with 3T and 7T MPRAGE enables detection of MS lesions in areas defined as NAWM using 3T FLAIR. Focal MS lesions contribute to the abnormalities known to exist in the NAWM. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390040 Fri, 04 Nov 2011 04:00:00 +0100 5390040 http://www.medworm.com/index.php?rid=5390039&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1301%3Frss%3D1 Conclusions: The present correlation study provides some evidence for the involvement of IL-13 in the modulation of neuronal integrity and synaptic function in patients with MS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390039 Fri, 04 Nov 2011 04:00:00 +0100 5390039 http://www.medworm.com/index.php?rid=5390038&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1295%3Frss%3D1 Conclusion: This study provides molecular evidence associating co-infection of type 1 and 2 EBV with MS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390038 Fri, 04 Nov 2011 04:00:00 +0100 5390038 http://www.medworm.com/index.php?rid=5390037&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1290%3Frss%3D1 Conclusion: In a study that controls for confounders, our data focus an EBNA-1 specificity that may be associated with MS pathogenesis. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390037 Fri, 04 Nov 2011 04:00:00 +0100 5390037 http://www.medworm.com/index.php?rid=5390036&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1282%3Frss%3D1 Conclusions: Our data confirm Sardinia as a high-risk area for MS and support the relevance of genetic factors in MS, as evidenced in St Peter Island. However, we found an unexpectedly high MS prevalence in one village, in particular in males, suggesting an environmental influence on MS occurrence. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390036 Fri, 04 Nov 2011 04:00:00 +0100 5390036 http://www.medworm.com/index.php?rid=5390035&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F11%2F1276%3Frss%3D1 Clinically significant depression can affect up to 50% of patients with multiple sclerosis over the course of their lifetime. It is associated with an increased morbidity and mortality and is regarded by patients as one of the main determinants of their quality of life. This review summarizes current perspectives relating to diagnosis, the utility of self report screening questionnaires, warning signs of suicidal intent and the biological and psychosocial variables implicated in mood change. In particular, the association between depression and structural brain abnormalities, including those derived from diffusion tensor imaging, is highlighted. Depression is treatable, as the results from randomized controlled trials of antidepressant medication, cognitive behavior therapy and mindfulness... Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390035 Fri, 04 Nov 2011 04:00:00 +0100 5390035 http://www.medworm.com/index.php?rid=5390034&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F11%2F1274%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390034 Fri, 04 Nov 2011 04:00:00 +0100 5390034 http://www.medworm.com/index.php?rid=5390057&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F10_suppl%2FS507%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390057 Wed, 02 Nov 2011 04:00:00 +0100 5390057 http://www.medworm.com/index.php?rid=5390056&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F10_suppl%2FS277%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390056 Wed, 02 Nov 2011 04:00:00 +0100 5390056 http://www.medworm.com/index.php?rid=5390055&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F10_suppl%2FS53%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390055 Wed, 02 Nov 2011 04:00:00 +0100 5390055 http://www.medworm.com/index.php?rid=5390054&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F10_suppl%2FS9%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5390054 Wed, 02 Nov 2011 04:00:00 +0100 5390054 http://www.medworm.com/index.php?rid=5298263&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1269%3Frss%3D1 The 6-minute walk test (6MWT) is often used to assess walking distance in multiple sclerosis (MS), but can be both time consuming for the investigator and exhausting for people with MS (pwMS). The present report compared the 6MWT scores of 40 ambulatory pwMS with their scores on the shorter 2-minute walk test (2MWT). The 2MWT estimated the 6MWT results with a mean relative error of 5% (R2 = 0.96; p < 0.01). As the last 4-minute period of the 6MWT seems redundant, the 2MWT may be considered as a practical replacement for the 6MWT in routine clinical assessment. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298263 Thu, 06 Oct 2011 04:00:00 +0100 5298263 http://www.medworm.com/index.php?rid=5298262&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1265%3Frss%3D1 The purposes of the study were (1) to estimate the risk of suicide attempts in multiple sclerosis (MS) patients in Denmark and compare the risk to the background population in the County of Funen, Denmark; (2) to estimate the risk of suicide attempts in MS patients receiving immunomodulating therapy compared with untreated patients. The Danish MS Registry, the Danish MS Treatment Registry and the Suicide Attempt Registry are linked and merged together using a person identification number given to all persons residing in Denmark. Among 404 MS patients, 15 patients had attempted suicide, although no increased risk for suicide attempts was found in MS patients. No difference in number of suicide attempts in treated and untreated patients was found. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298262 Thu, 06 Oct 2011 04:00:00 +0100 5298262 http://www.medworm.com/index.php?rid=5298261&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1262%3Frss%3D1 We report a patient with unexpected transition from long established PPMS to clinically and radiologically active RRMS after an ADEM-like fulminant demyelinating episode despite an immunosuppressive treatment preceding relapses. We note clearly accelerated brain atrophy after the RRMS course ensues. The unique disease course in this patient illustrates the dissociation of the biology and disability impact of relapses and progression. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298261 Thu, 06 Oct 2011 04:00:00 +0100 5298261 http://www.medworm.com/index.php?rid=5298260&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1258%3Frss%3D1 We describe a Paediatric Intensive Care Unit (PICU) population-based study to determine the epidemiology and clinical characteristics of children with ADEM requiring PICU admission or resulting in death. Anonymized data from the Paediatric Intensive Care Audit Network (PICANet) were obtained for all children under 16 years with a diagnosis of ADEM admitted to 25 PICUs in England and Wales (2004–2008). The Office for National Statistics (ONS) mortality database was also searched. In total, 27 PICANet cases (13 females:14 males; median age 4.8 years) were ascertained and all were alive on discharge. In addition, three cases were identified from the ONS mortality database. Of the 27 PICANet cases, clinical features included; seizures (n = 5); upper airway respiratory obstruction/stridor... Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298260 Thu, 06 Oct 2011 04:00:00 +0100 5298260 http://www.medworm.com/index.php?rid=5298259&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1250%3Frss%3D1 Conclusion: Patients receiving treatment were less distressed and had less depression and anxiety. There was some evidence of improved self-efficacy and a reduction of the impact of MS on people’s lives. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298259 Thu, 06 Oct 2011 04:00:00 +0100 5298259 http://www.medworm.com/index.php?rid=5298258&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1238%3Frss%3D1 Conclusion: Sociodemographic and clinical factors are linked to HRQoL in patients with MS. Interventions that affect these factors might be expected to influence HRQoL. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298258 Thu, 06 Oct 2011 04:00:00 +0100 5298258 http://www.medworm.com/index.php?rid=5298257&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1231%3Frss%3D1 Conclusions: In MS, there is no, or at best a weak association between severity of perceived fatigue and physical activity. Depending on the fatigue questionnaire used, patient characteristics such as age, type of MS, depression and anxiety are factors that may affect this relationship. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298257 Thu, 06 Oct 2011 04:00:00 +0100 5298257 http://www.medworm.com/index.php?rid=5298256&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1225%3Frss%3D1 Background: Neuromyelitis optica (NMO) is a severe demyelinating disease often leading to serious disability. Accumulating evidence now implicates humoral mechanisms in its pathogenesis. In the absence of an approved therapy, anti-inflammatory/immunosuppressant drugs have been used empirically for more than three decades. Recent evidence for a role of antibody to aquaporin-4 in the pathogenesis of NMO has led to the use of rituximab, a monoclonal antibody targeting the CD20 epitope on the entire B cell lineage. Objectives: To evaluate the impact of rituximab on the relapse rate and disability in NMO. Methods: This is an IRB approved retrospective longitudinal study of NMO patients treated with rituximab. Results: We identified 53 patients with NMO, 23 of whom had be... Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298256 Thu, 06 Oct 2011 04:00:00 +0100 5298256 http://www.medworm.com/index.php?rid=5298255&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1218%3Frss%3D1 Conclusions: Our data suggest that motor pathways are relatively resistant to chronic impairment from acute relapse, whereas afferent pathways are more susceptible. This, in combination with prominent usage of the Expanded Disability Status Scale, which is dependent on mobility and motor function at higher scores, may explain the paradox between natural history studies that suggest relapses are irrelevant to long-term disability and shorter studies at lower disability levels suggesting relapses are responsible for disability accumulation. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298255 Thu, 06 Oct 2011 04:00:00 +0100 5298255 http://www.medworm.com/index.php?rid=5298254&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1211%3Frss%3D1 Conclusions: Our investigations confirmed previously reported trends in ARR. In this context adaptive strategies such as BSSR designs are recommended for consideration in the planning of future trials in RRMS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298254 Thu, 06 Oct 2011 04:00:00 +0100 5298254 http://www.medworm.com/index.php?rid=5298253&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1202%3Frss%3D1 Conclusion: MRI visibility of CLs is determined by lesion size, and not by any distinctive underlying pathology. Visible CLs are associated with a higher total cortical lesion load, which suggests that when CLs in patients with MS become detectable on MRI, they merely represent ‘the tip of the pathological iceberg’. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298253 Thu, 06 Oct 2011 04:00:00 +0100 5298253 http://www.medworm.com/index.php?rid=5298252&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1194%3Frss%3D1 Conclusions: PGRN is strongly expressed in MS brains, by macrophages/microglia in active lesions, and by activated microglia in the NAWM; PGRN CSF concentrations in MS are correspondingly increased in conditions of enhanced macrophage/microglia activation, such as during relapses and in progressive MS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298252 Thu, 06 Oct 2011 04:00:00 +0100 5298252 http://www.medworm.com/index.php?rid=5298251&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1185%3Frss%3D1 Conclusions: Serum titers of pre-onset anti-EBNA antibodies are strong, robust markers of MS risk and could be useful in an MS risk score. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298251 Thu, 06 Oct 2011 04:00:00 +0100 5298251 http://www.medworm.com/index.php?rid=5298250&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1177%3Frss%3D1 Conclusion: This study shows that the relapsing phase is associated with reduced brain deactivation in the IPG, which is more marked in patients with a slow clinical recovery. Increased cortical excitability associated with inflammation may determine functional modifications within the ipsilateral motor area. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298250 Thu, 06 Oct 2011 04:00:00 +0100 5298250 http://www.medworm.com/index.php?rid=5298249&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F10%2F1176%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298249 Thu, 06 Oct 2011 04:00:00 +0100 5298249 http://www.medworm.com/index.php?rid=5298248&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F10%2F1174%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298248 Thu, 06 Oct 2011 04:00:00 +0100 5298248 http://www.medworm.com/index.php?rid=5298247&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F10%2F1171%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298247 Thu, 06 Oct 2011 04:00:00 +0100 5298247 http://www.medworm.com/index.php?rid=5298246&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F10%2F1170%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298246 Thu, 06 Oct 2011 04:00:00 +0100 5298246 http://www.medworm.com/index.php?rid=5298245&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1162%3Frss%3D1 MS incidence has significantly increased during the second half of the 20th century, generating considerable interest in analyzing the basis for this rise in the developed world. Particular emphasis is being placed on the role infections might play in exacerbating or preventing disease onset. Epidemiological data suggest that improvement in sanitation conditions and reduced exposure to infection might explain, at least in part, these changes. The hygiene hypothesis is not new and is currently used to explain the increasing incidence of allergies and other autoimmune diseases. Because helminths are powerful modulators of host immunity, some authors hypothesize that reduced parasite exposure due to improved hygiene conditions may favor MS development. We discuss epidemiological, experimental... Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298245 Thu, 06 Oct 2011 04:00:00 +0100 5298245 http://www.medworm.com/index.php?rid=5298244&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F10%2F1155%3Frss%3D1 The delayed conditioned eyeblink reflex, in which an individual learns to close the eyelid in response to a conditioned stimulus (e.g. a tone) relies entirely on the functional integrity of a cerebellar motor circuitry that involves the contingent activation of Purkinje cells by parallel and climbing fibres. Molecular changes that disrupt the function of this circuitry, in particular a loss of type-1 metabotropic glutamate receptors (mGlu1 receptors), occur in Purkinje cells of patients with multiple sclerosis and in mice with experimental autoimmune encephalomyelitis as a result of neuroinflammation. mGlu1 receptors are required for cerebellar motor learning associated with the conditioned eyeblink reflex. We propose that the delayed paradigm of the eyeblink conditioning might be particul... Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298244 Thu, 06 Oct 2011 04:00:00 +0100 5298244 http://www.medworm.com/index.php?rid=5298243&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F10%2F1152%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5298243 Thu, 06 Oct 2011 04:00:00 +0100 5298243 http://www.medworm.com/index.php?rid=5133767&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1146%3Frss%3D1 Cardiovascular autonomic dysfunction is not uncommon in multiple sclerosis (MS) and is related to the involvement of the vegetative areas of cardiac innervations in the medulla oblongata. It has been suggested that this may contribute to the occurrence of sudden death in MS. In this case report, we present a patient with active relapsing–remitting MS who died unexpectedly due to the sudden onset of cardiac arrythmias. Post-mortem examination showed the presence of active demyelinating lesions in the medulla oblongata. As far as we know, this is the first case report clearly linking sudden cardiac death to active MS on the histopathological level. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133767 Mon, 15 Aug 2011 23:00:00 +0100 5133767 http://www.medworm.com/index.php?rid=5133766&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1141%3Frss%3D1 Conclusions: Among memory-impaired patients, memory improved about 48.5% for those on l-amphetamine, but only 1.0% on placebo. Treatment with l-amphetamine produced large memory gains among memory-impaired MS patients. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133766 Mon, 15 Aug 2011 23:00:00 +0100 5133766 http://www.medworm.com/index.php?rid=5133765&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1130%3Frss%3D1 Conclusion: The results offer strong support for the viability of teleconference-delivered fatigue management education for enabling people with MS to manage this disabling symptom. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133765 Mon, 15 Aug 2011 23:00:00 +0100 5133765 http://www.medworm.com/index.php?rid=5133764&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1122%3Frss%3D1 Conclusion: Cortical lesions play an important role in CI. However, our results suggest that lesions that remain contained within the cortical ribbon do not play a more important role than ones extending into the adjacent white matter; furthermore, the size of the cortical lesion, and not the tissue-specific location, may better explain their correlation with CI. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133764 Mon, 15 Aug 2011 23:00:00 +0100 5133764 http://www.medworm.com/index.php?rid=5133763&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1113%3Frss%3D1 Conclusions: Lack of MRI remission during treatment with interferon beta-1b or glatiramer acetate is associated with higher relapse rate and worsening of physical and cognitive function. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133763 Mon, 15 Aug 2011 23:00:00 +0100 5133763 http://www.medworm.com/index.php?rid=5133762&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1107%3Frss%3D1 Conclusion: It is important to recognize that NMO or NMOSD can initially present with brain symptoms. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133762 Mon, 15 Aug 2011 23:00:00 +0100 5133762 http://www.medworm.com/index.php?rid=5133761&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1098%3Frss%3D1 Conclusions: Our findings show that grey matter volume is lower in secondary-progressive than in relapsing–remitting disease. Grey matter volume explained physical and cognitive impairment better than white matter volume, and is itself associated with T2 and T1 lesion volume. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133761 Mon, 15 Aug 2011 23:00:00 +0100 5133761 http://www.medworm.com/index.php?rid=5133760&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1088%3Frss%3D1 Conclusions: Temporal horn volume can be measured relatively easily and appears to correlate with two major clinical problems in MS patients: memory performance and depressive mood. The link between temporal horn volume, consolidation and depression may be hippocampal atrophy, as suggested by their adjacent neuroanatomical localization, and by the similarity in functional loss following impairment of these two structures. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133760 Mon, 15 Aug 2011 23:00:00 +0100 5133760 http://www.medworm.com/index.php?rid=5133759&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1079%3Frss%3D1 Conclusion: These findings indicate reduced fibre coherence in the main cerebellar connections, and link damage in the whole cerebellar WM, and, in particular, in the superior cerebellar peduncle, to motor deficit in PPMS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133759 Mon, 15 Aug 2011 23:00:00 +0100 5133759 http://www.medworm.com/index.php?rid=5133758&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1074%3Frss%3D1 Conclusion: The frequencies of antibodies appeared to be of the same magnitude in the four centres, but might be less than in the pivotal studies of natalizumab. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133758 Mon, 15 Aug 2011 23:00:00 +0100 5133758 http://www.medworm.com/index.php?rid=5133757&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1067%3Frss%3D1 Conclusion: The high syndrome specificity of the antibody for neuromyelitis optica spectrum disorders (NMOSDs) in patients with CTD supports the concept of AQP4-Ab being involved in the pathogenesis of these neurological conditions, and argues against AQP4-Ab simply being part of the polyclonal B cell activation generally associated with rheumatic diseases. Moreover, the finding that AQP4-Ab is present in patients with CTD and co-existing NMOSD with approximately the same frequency as in patients without CTD strengthens the case of CTD and AQP4-Ab positive NMOSD representing two co-existing yet distinct entities in the majority of patients. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133757 Mon, 15 Aug 2011 23:00:00 +0100 5133757 http://www.medworm.com/index.php?rid=5133756&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1060%3Frss%3D1 Conclusions: Familial MS differs from sporadic cases with respect to age at onset, multifocal involvement as first clinical event, and conversion into secondary progression. The progression rate of one out of two affected siblings may act as a predictor for the other sib. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133756 Mon, 15 Aug 2011 23:00:00 +0100 5133756 http://www.medworm.com/index.php?rid=5133755&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1055%3Frss%3D1 Conclusion: Our findings suggest a latitudinal prevalence gradient of MS in Latin American countries between Panama and Argentina. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133755 Mon, 15 Aug 2011 23:00:00 +0100 5133755 http://www.medworm.com/index.php?rid=5133754&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1041%3Frss%3D1 Conclusion: Exercise therapy has the potential to induce a positive effect on MS fatigue, but findings are heterogeneous probably because many studies have applied non-fatigued study populations. Furthermore, only few studies have evaluated MS fatigue as the primary outcome measure, emphasizing the need for future studies within this field. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133754 Mon, 15 Aug 2011 23:00:00 +0100 5133754 http://www.medworm.com/index.php?rid=5133753&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F9%2F1034%3Frss%3D1 Cognitive impairment is a prevalent, disabling, and poorly managed consequence of multiple sclerosis (MS). This underscores the importance of considering alternative approaches, such as exercise training, for managing cognitive impairment in persons with MS. The consideration of exercise training is warranted based on evidence summarized in literature reviews and meta-analyses that (1) aerobic fitness, physical activity, and exercise training are associated with better cognitive function in older adults; and (2) exercise training has comparable effects on mobility and quality of life outcomes in older adults and persons with MS. To date, research examining aerobic fitness, physical activity, and exercise training effects on cognition in MS is nascent and mostly includes cross-sectional des... Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133753 Mon, 15 Aug 2011 23:00:00 +0100 5133753 http://www.medworm.com/index.php?rid=5133752&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F9%2F1032%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5133752 Mon, 15 Aug 2011 23:00:00 +0100 5133752 http://www.medworm.com/index.php?rid=5031944&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F1022%3Frss%3D1 Conclusion: The reported prevalence and incidence figures in our study were higher than in our previous report of 2007, in which the prevalence and incidence of MS were reported to be 43.8 and 3.64 per 100,000, respectively. This dramatic increase in the prevalence of MS puts Isfahan amongst the regions with the highest prevalence of MS in Asia and Oceania and is mostly due to changing environmental factors, amongst which vitamin D deficiency seems an important factor in our population. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031944 Thu, 14 Jul 2011 23:00:00 +0100 5031944 http://www.medworm.com/index.php?rid=5031943&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F1017%3Frss%3D1 Conclusions: We conclude that, even with careful scheduling, it is difficult for a specialist service to obtain MRI scans and LP results so as to fulfil NICE guidelines within the optimal six-week period. An improved service would require MRI scans to be arranged before the first clinic visit in all patients with suspected MS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031943 Thu, 14 Jul 2011 23:00:00 +0100 5031943 http://www.medworm.com/index.php?rid=5031942&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F1010%3Frss%3D1 Conclusions: HW living in the USA may be at risk of developing MS at an earlier age compared with NHW. Migration history can play an important role in the management of HW with MS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031942 Thu, 14 Jul 2011 23:00:00 +0100 5031942 http://www.medworm.com/index.php?rid=5031941&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F1002%3Frss%3D1 Conclusions: In general, the study does not support modafinil as an effective treatment for MS fatigue. However, the study shows the need for new study designs and endpoints in MS fatigue studies. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031941 Thu, 14 Jul 2011 23:00:00 +0100 5031941 http://www.medworm.com/index.php?rid=5031940&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F991%3Frss%3D1 Conclusion: Quality of life, depression and fatigue remained largely stable over 3 years; no effects of treatment dose or baseline cognitive status were found. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031940 Thu, 14 Jul 2011 23:00:00 +0100 5031940 http://www.medworm.com/index.php?rid=5031939&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F980%3Frss%3D1 Conclusions: Gait speed is related to community walking, but an MIC in absolute gait speed could not be determined using a minimally important change on the MFWC or the EDSS as external criteria. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031939 Thu, 14 Jul 2011 23:00:00 +0100 5031939 http://www.medworm.com/index.php?rid=5031938&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F970%3Frss%3D1 Conclusion: These analyses demonstrate that sustained EDSS improvement is an additional measure that is sensitive to treatment effects over 2 years and correlates with quality of life. Further research is warranted to validate its use as an MS study clinical outcome. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031938 Thu, 14 Jul 2011 23:00:00 +0100 5031938 http://www.medworm.com/index.php?rid=5031937&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F964%3Frss%3D1 Conclusions: We report evidence for qualitatively distinct hyposmia in MS, with increased smell threshold in the early inflammatory phases of the disease and impaired identification with a more widespread chronic disease. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031937 Thu, 14 Jul 2011 23:00:00 +0100 5031937 http://www.medworm.com/index.php?rid=5031936&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F958%3Frss%3D1 Conclusion: Our data may support the notion that an elective termination of pregnancy due to natalizumab exposure may not be necessary, but rather requires careful monitoring. Women should still be advised to stop natalizumab in the course of planned pregnancy until more data on long-term outcomes are available. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031936 Thu, 14 Jul 2011 23:00:00 +0100 5031936 http://www.medworm.com/index.php?rid=5031935&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F949%3Frss%3D1 Conclusions: Intensity variations can have a large impact on black hole–EDSS correlation. Restricting the measurement to a subset of the darkest voxels may yield stronger correlations. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031935 Thu, 14 Jul 2011 23:00:00 +0100 5031935 http://www.medworm.com/index.php?rid=5031934&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F939%3Frss%3D1 Conclusions: This study indicates that early intervention with immunosuppressive agents may inhibit the generation of the neurodegenerative microenvironment, which is no longer responsive to potent immunosuppression. However, if treatment is initiated too late, progressive, neurological-disease continues unabated. This suggests that immunosuppression is insufficient to control secondary progression in animals, as has been found so far to be the case in MS, and may warrant early intervention with FTY720 for optimal treatment benefit. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031934 Thu, 14 Jul 2011 23:00:00 +0100 5031934 http://www.medworm.com/index.php?rid=5031933&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F931%3Frss%3D1 Conclusions: In the patient group regional AChE activities had inverse correlations with Word learning and MMSE (Mini-Mental State Examination) scores. In the group of cognitively deteriorated MS patients no change in cerebral AChE activity, compared with controls, was observed, but within the patient group more pronounced cognitive symptoms were associated with higher cerebral AChE activity. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031933 Thu, 14 Jul 2011 23:00:00 +0100 5031933 http://www.medworm.com/index.php?rid=5031932&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F922%3Frss%3D1 Discussion: Homozygosity for the IL7R exon 6 rs6897932 C allele is associated with a higher risk for MS in our Dutch population. No effect was found of genotype or mRNA expression on disease phenotype. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031932 Thu, 14 Jul 2011 23:00:00 +0100 5031932 http://www.medworm.com/index.php?rid=5031931&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F914%3Frss%3D1 Conclusions: The present study provides preliminary evidence that the gain-of-function p.82G>S polymorphism in the RAGE gene is associated with an increased risk of MS in the Chinese population. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031931 Thu, 14 Jul 2011 23:00:00 +0100 5031931 http://www.medworm.com/index.php?rid=5031930&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F909%3Frss%3D1 Conclusion:A total population study is the most reliable method of determining the spectrum of clinical symptoms and the results of investigations in MS patients at diagnosis. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031930 Thu, 14 Jul 2011 23:00:00 +0100 5031930 http://www.medworm.com/index.php?rid=5031929&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F8%2F901%3Frss%3D1 Conclusions: The MS prevalence of 188.9/100,000 in Sweden is among the highest nationwide prevalence estimates in the world. In Sweden, the risk of MS increases with increasing north latitude for both men and women. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=5031929 Thu, 14 Jul 2011 23:00:00 +0100 5031929 http://www.medworm.com/index.php?rid=4947518&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F7%2F895%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=4947518 Sun, 19 Jun 2011 23:00:00 +0100 4947518 http://www.medworm.com/index.php?rid=4947517&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F7%2F893%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=4947517 Sun, 19 Jun 2011 23:00:00 +0100 4947517 http://www.medworm.com/index.php?rid=4947516&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F7%2F891%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=4947516 Sun, 19 Jun 2011 23:00:00 +0100 4947516 http://www.medworm.com/index.php?rid=4947515&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F7%2F890%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=4947515 Sun, 19 Jun 2011 23:00:00 +0100 4947515 http://www.medworm.com/index.php?rid=4947514&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Freprint%2F17%2F7%2F888%3Frss%3D1 (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=4947514 Sun, 19 Jun 2011 23:00:00 +0100 4947514 http://www.medworm.com/index.php?rid=4947513&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F7%2F885%3Frss%3D1 This report describes, for the first time, an occurrence of wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) in a 19-year-old female with neuromyelitis optica (NMO) spectrum disorder, who had anti-aquaporin-4 (AQP4) antibody. A high signal intensity lesion on T2-weighted MRI was detected in the midbrain tegmentum adjacent to the aqueduct, and presumably involved the medial longitudinal fasciculus bilaterally at the caudal levels. Plasma exchange resolved both WEBINO syndrome and the midbrain lesion. Although WEBINO syndrome is occasionally reported in multiple sclerosis patients, diagnosis of NMO should not be excluded in patients with WEBINO syndrome, because AQP4 is expressed abundantly around the periaqueductal region. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=4947513 Sun, 19 Jun 2011 23:00:00 +0100 4947513 http://www.medworm.com/index.php?rid=4947512&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F7%2F876%3Frss%3D1 Conclusions: Patients with benign MS had better PROs than other groups of MS patients, suggesting that both disease duration and disability influence PROs. The study also showed a difference in PROs based on the way benign MS was defined. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=4947512 Sun, 19 Jun 2011 23:00:00 +0100 4947512 http://www.medworm.com/index.php?rid=4947511&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F7%2F867%3Frss%3D1 Conclusion: This large cohort with at least 5 years of follow-up provided good insights into the long-term safety profile of MITOX in MS. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=4947511 Sun, 19 Jun 2011 23:00:00 +0100 4947511 http://www.medworm.com/index.php?rid=4947510&cid=s_38862_25_f&fid=38862&url=http%3A%2F%2Fmsj.sagepub.com%2Fcgi%2Fcontent%2Fabstract%2F17%2F7%2F851%3Frss%3D1 Conclusions: Multiple sclerosis patients might benefit from reparative, and not solely from anti-inflammatory, effects of glucocorticoids. Interactive effects of glucocorticoid- and IFNβ-treatment need to be considered to improve neuroprotection and remyelination resulting from immunomodulatory treatment. (Source: Multiple Sclerosis) Multiple Sclerosis journals http://www.medworm.com/rss/comments.php?id=4947510 Sun, 19 Jun 2011 23:00:00 +0100 4947510