MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Muscle and Nerve' source. Thu, 09 Feb 2012 09:15:15 +0100 http://www.medworm.com/index.php?rid=5663237&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23344 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5663237 Mon, 06 Feb 2012 05:00:00 +0100 5663237 http://www.medworm.com/index.php?rid=5663236&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23343 Discussion:Submaximal muscle stimulation can be used to estimate VA in the knee extensors. It is less painful, and overestimation of VA may be less compared to maximal nerve stimulation. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5663236 Mon, 06 Feb 2012 05:00:00 +0100 5663236 http://www.medworm.com/index.php?rid=5663235&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23342 Conclusions:While ZAM is an uncommon occurrence following cutaneous HZ, it is associated with significant weakness, high rates of post‐herpetic neuralgia, and prolonged morbidity. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5663235 Mon, 06 Feb 2012 05:00:00 +0100 5663235 http://www.medworm.com/index.php?rid=5663234&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23341 Discussion.This induced fibrotic dystrophic model may be useful to study mechanisms of fibrosis in dystrophinopathies and to evaluate antifibrotic treatments. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5663234 Mon, 06 Feb 2012 05:00:00 +0100 5663234 http://www.medworm.com/index.php?rid=5663233&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23340 DISCUSSION.GSGC is a group of functional tests that require only few minutes to perform, therefore, this score might be a good indicator to be used in future studies. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5663233 Mon, 06 Feb 2012 05:00:00 +0100 5663233 http://www.medworm.com/index.php?rid=5663232&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23339 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5663232 Mon, 06 Feb 2012 05:00:00 +0100 5663232 http://www.medworm.com/index.php?rid=5663231&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23338 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5663231 Mon, 06 Feb 2012 05:00:00 +0100 5663231 http://www.medworm.com/index.php?rid=5663230&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23337 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5663230 Wed, 01 Feb 2012 05:00:00 +0100 5663230 http://www.medworm.com/index.php?rid=5642283&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23327 This study aimed to obtain normal MUAP values in two facial muscles and to compare the results of different analysis methods.Methods:The frontalis muscle of 36 and the mentalis muscle of 28 normal subjects were examined, and mean and outlier values of all MUAP parameters were calculated with the automatic method. Next, manual editing of the recorded raw data provided new sets of values for comparison.Results:The frontalis muscle MUAPs have significantly shorter duration, smaller amplitude and a lower number of turns and phases compared to those of mentalis. Higher MUAP duration values in the frontalis were the only significant difference after the comparison of the different analysis methods.Discussion:The set of normal values for frontalis and mentalis in this study could be useful in rou... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5642283 Mon, 30 Jan 2012 17:25:24 +0100 5642283 http://www.medworm.com/index.php?rid=5642287&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23331 This study provides evidence that doxycycline may be a potential therapeutic agent for DMD. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5642287 Mon, 30 Jan 2012 05:00:00 +0100 5642287 http://www.medworm.com/index.php?rid=5642286&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23330 AbstractThe recommendations for clinical research standards published in 2000 by a task force of the Medical Scientific Advisory Board (MSAB) of the Myasthenia Gravis Foundation of America (MGFA) were largely successful in introducing greater uniformity in the recording and reporting of MG clinical trials. Recognizing that changes in clinical trial design and implementation may increase the likelihood that new therapies are developed for MG, the MGFA MSAB Task Force here presents updated recommendations for the design and implementation of clinical trials in MG, including (a) the use of a quantitative measure, such as the MG‐Composite, that is weighted for clinical significance and incorporates patient reported outcomes; (b) consideration of non‐trial strategies and (c) development of ... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5642286 Mon, 30 Jan 2012 05:00:00 +0100 5642286 http://www.medworm.com/index.php?rid=5642285&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23329 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5642285 Mon, 30 Jan 2012 05:00:00 +0100 5642285 http://www.medworm.com/index.php?rid=5642284&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23328 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5642284 Mon, 30 Jan 2012 05:00:00 +0100 5642284 http://www.medworm.com/index.php?rid=5633670&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23323 The objective of this study was to determine if the presence or absence of a palmaris longis tendon influenced the function of the median nerve across the wrist. The primary hypothesis was that the presence of a palmaris longus tendon would be associated with more median nerve entrapment at the wrist.Methods:This was a cross‐sectional study. Subjects were recruited at a screening of dental professionals. The median and ulnar sensory nerve latencies across the wrist (relative prolongation of the median compared to the ulnar) and the presence or absence of the palmaris longus tendon were the primary outcome measures.Results:462 subjects were recruited into the study of which 16.2% lacked a palmaris longus tendon. There was no difference in the median nerve function or the percentage with a... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5633670 Fri, 27 Jan 2012 14:11:36 +0100 5633670 http://www.medworm.com/index.php?rid=5633673&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23326 Discussion:Increases in thigh muscle strength were relative to those in muscle size, suggesting that muscle growth may play an important role in the development of strength during childhood. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5633673 Wed, 25 Jan 2012 05:00:00 +0100 5633673 http://www.medworm.com/index.php?rid=5633672&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23325 Discussion:Ultrasound demonstrated structural nerve abnormalities in GBS. These changes normalized as the patient improved clinically and electrophysiologically. Further studies are needed to elucidate the diagnostic and prognostic value of ultrasound in GBS. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5633672 Wed, 25 Jan 2012 05:00:00 +0100 5633672 http://www.medworm.com/index.php?rid=5633671&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23324 The objective was to evaluate handgrip strength in the RASopathies.Methods:Individuals with RASopathies [e.g. Noonan syndrome, Costello syndrome, cardio‐facio‐cutaneous (CFC) syndrome, and neurofibromatosis type 1 (NF1)] and healthy controls were evaluated. Two methods of handgrip strength were tested: GRIP‐D Takei Hand Grip Dynamometer and the Martin vigorimeter. A general linear model was fitted to compare average strength among the groups, controlling for confounders such as age, gender, height, and weight.Results:Takei dynamometer: handgrip strength was decreased in each of the syndromes compared to controls. Decreased handgrip strength compared to sibling controls was also seen with the Martin vigorimeter (p<0.0001).Discussion:Handgrip strength is decreased in the RASopathies... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5633671 Wed, 25 Jan 2012 05:00:00 +0100 5633671 http://www.medworm.com/index.php?rid=5623606&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23314 AbstractHere we review recent research into the mechanisms of chronic pain that has focused on neuronal sodium channels, a target of classic analgesic agents. We first discuss evidence that specific sodium channel isoforms are essential for the detection and conduction of normal acutely painful stimuli from nociceptors. We then review findings that show changes in sodium channel expression and localization in chronic inflammation and nerve injury in animal and human tissues. We conclude by discussing the role that myelination plays in organizing and maintaining sodium channel clusters at nodes of Ranvier in normal development and how inflammatory processes or nerve injury alter the characteristics of such clusters. Based on these findings, we suggest that chronic pain may in part result fr... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5623606 Tue, 24 Jan 2012 14:12:22 +0100 5623606 http://www.medworm.com/index.php?rid=5623614&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23322 This study determined the between‐session reliability of neuromuscular measurements during explosive contractions, with special consideration of EMG normalization.Methods:Following familiarization, thirteen men participated in three identical measurement sessions involving maximal and explosive voluntary contractions of the knee extensors, while force and surface EMG were recorded. RMS EMG amplitude was normalized to different reference measures: (evoked maximal M‐wave peak‐to‐peak amplitude and area, maximum and sub‐maximum voluntary contractions).Results:Explosive voluntary force measurements were reliable on a group level, whereas within‐subject reliability was low over the initial 50 ms and good from 100 ms onwards. Normalization of EMG during explosive voluntary contractio... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5623614 Tue, 24 Jan 2012 05:00:00 +0100 5623614 http://www.medworm.com/index.php?rid=5623613&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23321 Discussion:Progressive myopathy involvement could be a hitherto unknown manifestation of APECED. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5623613 Tue, 24 Jan 2012 05:00:00 +0100 5623613 http://www.medworm.com/index.php?rid=5623612&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23320 Conclusions:Since mood and illness perception explain significant variance in QoL in muscle disease, there is scope for devising psychosocial interventions that may improve QoL for those with muscle disease. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5623612 Tue, 24 Jan 2012 05:00:00 +0100 5623612 http://www.medworm.com/index.php?rid=5623611&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23319 Conclusions:C8 radiculopathy without C8‐root compression may be due to C7‐root compression in the setting of a “pre‐fixed” brachial plexus, upper cervical cord compression with vascular compromise of the distal cervical spinal cord (“myelopathic hand”), or intramedullary cervical cord lesions. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5623611 Tue, 24 Jan 2012 05:00:00 +0100 5623611 http://www.medworm.com/index.php?rid=5623610&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23318 Discussion:These results indicate that carrageenan directly affects contractile function and causes skeletal muscle weakness. Local muscle inflammation may contribute to the weakness observed in inflammatory related disorders. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5623610 Tue, 24 Jan 2012 05:00:00 +0100 5623610 http://www.medworm.com/index.php?rid=5623609&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23317 Conclusion:In elderly individuals, gender influences the mRNA expression of certain myokines and growth factors, both at rest and after resistance exercise. These differences may influence muscle regeneration following muscle injury. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5623609 Tue, 24 Jan 2012 05:00:00 +0100 5623609 http://www.medworm.com/index.php?rid=5623608&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23316 Conclusion:The findings provide evidence for corticomotor adaptation for unilateral leg strength training within the iM1 that is modulated by changes in interhemispheric inhibition. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5623608 Tue, 24 Jan 2012 05:00:00 +0100 5623608 http://www.medworm.com/index.php?rid=5623607&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23315 CONCLUSIONS:Progressive brachial diplegia is a rare neuromuscular presentation of WNV neuroinvasive disease. This case report adds to the clinical spectrum of WNV‐induced neurologic sequelae. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5623607 Tue, 24 Jan 2012 05:00:00 +0100 5623607 http://www.medworm.com/index.php?rid=5602488&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23313 Conclusion –Low HR CV is a potential marker of prognosis in ALS. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5602488 Wed, 18 Jan 2012 14:53:35 +0100 5602488 http://www.medworm.com/index.php?rid=5590726&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23300 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590726 Sun, 15 Jan 2012 03:12:17 +0100 5590726 http://www.medworm.com/index.php?rid=5590725&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23299 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590725 Sun, 15 Jan 2012 03:12:16 +0100 5590725 http://www.medworm.com/index.php?rid=5590724&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23297 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590724 Sun, 15 Jan 2012 03:12:15 +0100 5590724 http://www.medworm.com/index.php?rid=5590723&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22247 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590723 Sun, 15 Jan 2012 03:12:10 +0100 5590723 http://www.medworm.com/index.php?rid=5590722&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22261 We report a 16‐year‐old boy with subacute, fluctuating, progressive muscle pain, with tenderness, swelling, and diffuse, asymmetric weakness. He also had significantly elevated serum Brucella titers and a muscle biopsy showed inflammatory granulomatous myositis. We review the literature on myositis associated with brucellosis. Muscle Nerve, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590722 Sun, 15 Jan 2012 03:12:05 +0100 5590722 http://www.medworm.com/index.php?rid=5590721&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22252 We describe a large Brazilian consanguineous kindred with 3 clinically affected patients with a Thomsen myotonia phenotype. They carry a novel homozygous nonsense mutation in the CLCN1 gene (K248X). None of the 6 heterozygote carriers show any sign of myotonia on clinical evaluation or electromyography. These findings confirm the autosomal recessive inheritance of the novel mutation in this family, as well as the occurrence of phenotypic variability in the autosomal recessive forms of myotonia. Muscle Nerve, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590721 Sun, 15 Jan 2012 03:12:02 +0100 5590721 http://www.medworm.com/index.php?rid=5590720&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22277 Conclusion: High‐frequency sonography permits high‐resolution imaging of the volar digital nerves. Muscle Nerve, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590720 Sun, 15 Jan 2012 03:11:51 +0100 5590720 http://www.medworm.com/index.php?rid=5590719&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22288 Conclusion:In this study we describe the abnormal expression of the IGF‐1 system in skeletal muscle of sALS patients that could participate in motor neuron degeneration and should be taken into account when developing treatments with IGF‐1. Muscle Nerve, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590719 Sun, 15 Jan 2012 03:11:48 +0100 5590719 http://www.medworm.com/index.php?rid=5590718&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22279 Conclusions: NM is associated with SLE, hypertension, and diabetes mellitus. Comprehensive assessment of cardiovascular risk is indicated in NM, which raises the possibility of targeted interventions. Muscle Nerve, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590718 Sun, 15 Jan 2012 03:11:45 +0100 5590718 http://www.medworm.com/index.php?rid=5590717&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22264 Conclusions: Symptoms improved more rapidly than function after surgery. Measurement of the ultrasonographic CSA ratio may provide clinicians with a useful assessment tool after surgery. Muscle Nerve, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590717 Sun, 15 Jan 2012 03:11:44 +0100 5590717 http://www.medworm.com/index.php?rid=5590716&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22299 Conclusion: The sensitivity of the Awaji algorithm is lower than that of the R‐EEC. Muscle Nerve, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590716 Sun, 15 Jan 2012 03:11:43 +0100 5590716 http://www.medworm.com/index.php?rid=5590715&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22321 Conclusions: Quadriceps (knee extensor) strength correlated with performance in this large cohort of sIBM subjects, which demonstrated its potential to predict function in this disease. These data provide initial support for use of muscle strength as a surrogate for function, although validation in a clinical trial is required. Muscle Nerve, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590715 Sun, 15 Jan 2012 03:11:41 +0100 5590715 http://www.medworm.com/index.php?rid=5590714&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23278 AbstractRecent findings highlight a pathologic and functional convergence in amyotrophic lateral sclerosis (ALS) and amyotrophic lateral sclerosis with frontotemporal dementia (ALS‐FTD) at the level of protein recycling and disposal. Genes linked to rare cases of familial ALS and ALS‐FTD, like UBQLN2, OPTN, SQSTM1/p62, and VCP, may converge onto a unifying pathogenic pathway and thereby provide novel therapeutic targets common to a spectrum of etiologically diverse forms of ALS and ALS‐FTD. Interactions between these genes need to be further explored to understand their common molecular pathways. Future efforts should be directed toward generation and characterization of in vivo models to dissect the pathogenic mechanisms of ALS and ALS‐FTD and the role of protein degradation pathw... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590714 Sun, 15 Jan 2012 03:11:39 +0100 5590714 http://www.medworm.com/index.php?rid=5590713&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23301 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590713 Sun, 15 Jan 2012 03:11:38 +0100 5590713 http://www.medworm.com/index.php?rid=5590712&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23298 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590712 Sun, 15 Jan 2012 03:11:37 +0100 5590712 http://www.medworm.com/index.php?rid=5590706&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23309 Conclusions:These results suggest that improvements in mitochondrial respiratory and antioxidant capacities following endurance training protected them against statin exposure. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590706 Sun, 15 Jan 2012 03:09:15 +0100 5590706 http://www.medworm.com/index.php?rid=5590709&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23312 We examined patterns of phosphorylation of key MAP kinase proteins in cultured myotubes responding to oxidative stress, and in muscle tissue in vivo. Results: Dystrophic (mdx) myotubes have an increased susceptibility to oxidant‐induced death compared with wild type (C57Bl/10ScSn) myotubes. This correlates with late phosphorylation of c‐Jun N‐terminal kinase (JNK), and persistently high p38 MAP kinase phosphorylation in mdx myotubes. JNK and extracellular signal‐regulated kinase 1/2 (ERK1/2) also showed altered phosphorylation levels in mdx muscle tissue. Discussion: We show altered patterns of MAP kinase protein phosphorylation in dystrophic muscle in vitro and in vivo. These pathways may be novel pharmacological targets for treating DMD. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590709 Fri, 13 Jan 2012 05:00:00 +0100 5590709 http://www.medworm.com/index.php?rid=5590708&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23311 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590708 Fri, 13 Jan 2012 05:00:00 +0100 5590708 http://www.medworm.com/index.php?rid=5590707&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23310 ConclusionsDespite frequent use in human clinical care, published evidence for the 1 to 4 week guideline comes almost entirely from animal studies. An appreciation of this background and resulting limitations aids clinical application of this guideline. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590707 Fri, 13 Jan 2012 05:00:00 +0100 5590707 http://www.medworm.com/index.php?rid=5590711&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23308 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590711 Wed, 11 Jan 2012 05:00:00 +0100 5590711 http://www.medworm.com/index.php?rid=5590710&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23307 We present data using a handheld electrode array (HEA) that we devised to expedite the EIM procedure in a clinical setting.Methods:Thirty‐four healthy volunteers and 24 radiculopathy subjects underwent EIM testing using the HEA and adhesive electrodes.Results:The HEA was shown to have good test‐retest reproducibility, with intraclass correlation coefficients as high as 0.99. HEA data correlated strongly with data from adhesive electrodes, ρ = 0.85 in healthy volunteers (p < 0.001) and ρ = 0.75 in radiculopathy subjects (p < 0.001).Discussion:These data support the potential use of a handheld array for performing rapid localized surface impedance measurements. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5590710 Wed, 11 Jan 2012 05:00:00 +0100 5590710 http://www.medworm.com/index.php?rid=5566972&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23292 Conclusion:Low‐amplitude MUPs in the FDP muscle indicate the presence of an advanced myopathy in this muscle that was extremely weak for all subjects. Examining the FDP muscle would reduce the chance of misdiagnosing IBM as ALS. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566972 Fri, 06 Jan 2012 05:00:00 +0100 5566972 http://www.medworm.com/index.php?rid=5566971&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23291 DiscussionThese results suggest there is no association between chronic systemic inflammation in RA and age‐related muscle characteristics. Future research should focus on inflammation and satellite cell function. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566971 Fri, 06 Jan 2012 05:00:00 +0100 5566971 http://www.medworm.com/index.php?rid=5566970&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23290 Conclusion:These results are consistent with the concept of ‘hierarchical order of fiber activation’, suggesting that the magnitude of twitch potentiation reflects the activation of fast‐twitch fibers during a brief contraction. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566970 Fri, 06 Jan 2012 05:00:00 +0100 5566970 http://www.medworm.com/index.php?rid=5566969&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23289 CONCLUSIONS:Women are more susceptible to the adaptations of muscle unloading, and disturbances in neural drive from the central nervous system are probably responsible. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566969 Fri, 06 Jan 2012 05:00:00 +0100 5566969 http://www.medworm.com/index.php?rid=5566968&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23288 Discussion:Paraspinal electromyography can be considered safe in the general population and those taking non‐steroidal anti‐inflammatory drugs. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566968 Fri, 06 Jan 2012 05:00:00 +0100 5566968 http://www.medworm.com/index.php?rid=5566967&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23287 Discussion:The spectrum of immunoglobulin deposition in muscle is similar to other organs. It comprises a continuum that includes parenchymal amyloid deposition, amyloid angiopathy, and non‐congophilic Light Chain Deposition Disease (LCDD). We recommend including the FLC assay in the routine investigation for monoclonal gammopathies. This case also highlights the value of MRI‐guided muscle biopsy. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566967 Fri, 06 Jan 2012 05:00:00 +0100 5566967 http://www.medworm.com/index.php?rid=5566966&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23286 Conclusions:This proposed approach provides a sensitive and reliable method for evaluating and characterizing MUAPs. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566966 Fri, 06 Jan 2012 05:00:00 +0100 5566966 http://www.medworm.com/index.php?rid=5566965&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23285 We describe an unusual case of MFS that presented with dramatic bilateral proptosis and chemosis. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566965 Fri, 06 Jan 2012 05:00:00 +0100 5566965 http://www.medworm.com/index.php?rid=5566964&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23284 Conclusions:Prepatterned nAChR aggregation is required for Ca2+ spikes and twitching of developing myotubes. Moreover, prepatterned nAChR‐driven electrical activity preserves the distribution of nAChRs, mimicking the effect of synaptic activity before innervation. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566964 Fri, 06 Jan 2012 05:00:00 +0100 5566964 http://www.medworm.com/index.php?rid=5566963&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23306 Discussion:Several of the dysregulated proteins play a role in cytoskeletal reorganization. Based on these findings, we speculate that disturbed cytoskeletal regulation is responsible for formation of aggregates of intermediate filaments. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566963 Fri, 06 Jan 2012 05:00:00 +0100 5566963 http://www.medworm.com/index.php?rid=5566962&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23305 Conclusions:Our results support a good prognosis in essentially all patients with acute compressive radial neuropathies. This report provides valuable information to assist in counseling patients who may present with profound clinical deficits. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566962 Fri, 06 Jan 2012 05:00:00 +0100 5566962 http://www.medworm.com/index.php?rid=5566961&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23304 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566961 Fri, 06 Jan 2012 05:00:00 +0100 5566961 http://www.medworm.com/index.php?rid=5566960&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23303 ConclusionReflex detection sensitivity decreases with increasing measuring area and increasing IED. These results stress that for determination of RRF and similar tasks, DD recordings should be applied. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566960 Fri, 06 Jan 2012 05:00:00 +0100 5566960 http://www.medworm.com/index.php?rid=5566959&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23302 Discussion:The incidence and prevalence of idiopathic inflammatory myopathies in the managed care plan studied was higher than previously reported in the U.S. Because of the limitations inherent in claims analysis, additional research is needed to substantiate these results. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566959 Fri, 06 Jan 2012 05:00:00 +0100 5566959 http://www.medworm.com/index.php?rid=5566958&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23296 Discussion:Our study highlights the high prevalence of sleep disturbance among MG patients. Disease severity may be considered to be a MG‐specific risk factor for patient‐reported sleep disturbance. The MG‐QOL15 and PSQI should be employed to estimate the impact of the disease on sleep and quality of life. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566958 Fri, 06 Jan 2012 05:00:00 +0100 5566958 http://www.medworm.com/index.php?rid=5566957&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23293 This study was undertaken to determine whether sarcolemmal dysfunction could be identified with muscle velocity recovery cycles (MVRCs).Methods:Eleven genetically confirmed ATS patients and 20 normal controls were studied. MVRCs were recorded with 1, 2 and 5 conditioning stimuli and with single conditioning stimuli during intermittent repetitive stimulation at 20 Hz, in addition to the long exercise test.Results:ATS patients had longer relative refractory periods (P<0.0001) and less early supernormality, consistent with membrane depolarization. Patients had reduced enhancement of late supernormality with 5 conditioning stimuli (P<0.0001), and less latency reduction during repetitive stimulation (P<0.001). Patients were separated completely from controls by combining MVRC and repet... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566957 Fri, 06 Jan 2012 05:00:00 +0100 5566957 http://www.medworm.com/index.php?rid=5566956&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23294 DISCUSSION:Cardiac involvement represents a very common phenotypic expression of LMNA gene mutation. Subjects sharing common genetic background seem to suffer from analogue pattern of cardiac manifestation. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566956 Fri, 06 Jan 2012 05:00:00 +0100 5566956 http://www.medworm.com/index.php?rid=5566955&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23295 Discussion:Based on the positive outcome of the delivery system, we plan to study the delivery system over longer time courses of release and nerve regeneration. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566955 Fri, 06 Jan 2012 05:00:00 +0100 5566955 http://www.medworm.com/index.php?rid=5566954&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23283 This report is a meta‐analysis of the human muscle architecture literature that analyzes the number of muscles, number of subjects, and muscle fiber length coefficient of variation (CV) by body region.METHODS:Muscle fiber length data are used to make recommendations for dissection‐based architectural study sample sizes.RESULTS:An average of 9 ± 10 (mean ± SD) muscles and an average of 9 ± 5 subjects were reported in the 26 studies considered. Across all studies, average fiber length CV was highly variable (18% ± 5%). This shows that sample sizes required to achieve adequate power varies by anatomical region.DISCUSSION:Studies involving muscle architecture should consider regional variability and effect size and determine sample size accordingly. © 2012 Wiley‐Liss, Inc. (Source: ... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566954 Fri, 06 Jan 2012 05:00:00 +0100 5566954 http://www.medworm.com/index.php?rid=5566953&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23282 AbstractRespiratory complications are a common cause of morbidity and mortality in amyotrophic lateral sclerosis (ALS). Treatment of respiratory insufficiency with noninvasive ventilation (NIV) improves ALS patients' quality of life and survival. Evidence‐based practice guidelines for the management of ALS patients recommend treatment of respiratory insufficiency with NIV as well as consideration of insufflation/exsufflation to improve clearance of airway secretions. Despite these recommendations respiratory therapies remain underutilized. In this review we provide a practical guide for the clinician to prescribe and manage respiratory therapies for the patient with ALS. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566953 Fri, 06 Jan 2012 05:00:00 +0100 5566953 http://www.medworm.com/index.php?rid=5566952&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23281 Discussion:The cases reported here should help to better understand the important role of mutation screening in the ANO5 gene in patients with adult onset muscular dystrophy and very high CK levels. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566952 Fri, 06 Jan 2012 05:00:00 +0100 5566952 http://www.medworm.com/index.php?rid=5566951&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23280 Discussion:Suramin's positive effect on muscle regeneration is thought to be due to its enhancement of follistatin expression which increases neoangiogenesis and inhibits myostatin's promotion of fibrosis. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566951 Fri, 06 Jan 2012 05:00:00 +0100 5566951 http://www.medworm.com/index.php?rid=5566950&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23279 Discussion:The Mediracer should only be used in patients with typical CTS symptoms and signs and no muscle wasting who have had careful neurological assessment. © 2012 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5566950 Sun, 01 Jan 2012 05:00:00 +0100 5566950 http://www.medworm.com/index.php?rid=5531154&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23264 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531154 Fri, 23 Dec 2011 03:01:19 +0100 5531154 http://www.medworm.com/index.php?rid=5531153&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23263 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531153 Fri, 23 Dec 2011 03:01:17 +0100 5531153 http://www.medworm.com/index.php?rid=5531152&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23262 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531152 Fri, 23 Dec 2011 03:01:16 +0100 5531152 http://www.medworm.com/index.php?rid=5531150&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22271 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531150 Fri, 23 Dec 2011 03:01:15 +0100 5531150 http://www.medworm.com/index.php?rid=5531149&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22239 We report this unique case in that flecainide‐induced sensory neuropathy was confirmed with skin biopsy, and subsequent improvement of neuropathy was documented with assessment of intraepidermal nerve fiber density in a repeat nerve biopsy. Muscle Nerve 45: 144–146, 2011 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531149 Fri, 23 Dec 2011 03:01:12 +0100 5531149 http://www.medworm.com/index.php?rid=5531148&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22223 We report a patient with diffuse large B‐cell lymphoma (DLBCL) who initially presented as Miller Fisher syndrome (MFS) responsive to high‐dose immunoglobulin treatment. Detailed investigations for the recurrence of neurological symptoms revealed DLBCL that was responsive to chemotherapy. DLBCL should be considered in the differential diagnosis of patients with MFS who have worsening of their neurological condition after initial improvement with conventional therapy. Muscle Nerve 45: 138–143, 2011 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531148 Fri, 23 Dec 2011 03:01:11 +0100 5531148 http://www.medworm.com/index.php?rid=5531147&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22270 Conclusions:The relationships between some coping strategies and certain dimensions of HRQoL are shown. We now understand the usefulness of focusing on coping strategies to improve HRQoL in ALS. Muscle Nerve 45: 131–134, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531147 Fri, 23 Dec 2011 03:01:08 +0100 5531147 http://www.medworm.com/index.php?rid=5531146&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22256 AbstractThe protein kinase product of the gene mutated in myotonic dystrophy 1 (DMPK) is reported to play a role in cardiac pathophysiology. To gain insight into the molecular mechanisms modulated by DMPK, we characterize the impact of DMPK ablation in the context of cardiac β‐adrenergic function. Our data demonstrate that DMPK knockout mice present altered β‐agonist–induced responses and suggest that this is due, at least in part, to a reduced density of β1‐adrenergic receptors in cardiac plasma membranes. Muscle Nerve 45: 128–130, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531146 Fri, 23 Dec 2011 03:01:07 +0100 5531146 http://www.medworm.com/index.php?rid=5531144&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22257 Conclusions: These results indicate that, at similar levels of EMG activity, GM and TA muscles elicit a higher mechanical output while acting as an antagonist. These findings have important implications for muscle function testing. They show that estimation of antagonistic force using the common method based on the EMG/net torque relationship yields underestimated values. Muscle Nerve 45: 92–99, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531144 Fri, 23 Dec 2011 03:01:00 +0100 5531144 http://www.medworm.com/index.php?rid=5531143&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22255 Conclusions:NLD‐SFSN is more common in women, presents at a younger age, and is more likely to be associated with immune‐mediated conditions than LD‐SFSN. Muscle Nerve 45: 86–91, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531143 Fri, 23 Dec 2011 03:00:59 +0100 5531143 http://www.medworm.com/index.php?rid=5531142&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22253 Conclusions:ATLIS is convenient for patients and evaluators, produces precise strength measurements, and is easily moved between examining rooms. Muscle Nerve 45: 81–85, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531142 Fri, 23 Dec 2011 03:00:58 +0100 5531142 http://www.medworm.com/index.php?rid=5531140&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22249 Conclusions:Pain of moderate severity and unpleasant muscular symptoms are common in DM2. DM2 should be taken into consideration in the differential diagnosis of musculoskeletal pain. Muscle Nerve 45: 70–74, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531140 Fri, 23 Dec 2011 03:00:55 +0100 5531140 http://www.medworm.com/index.php?rid=5531139&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22234 Conclusions: This study provides evidence of plasticity of DRG neurons induced by HU. The changes observed might contribute to impaired motor performance in rats submitted to HU. Muscle Nerve 45: 65–69, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531139 Fri, 23 Dec 2011 03:00:54 +0100 5531139 http://www.medworm.com/index.php?rid=5531137&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22219 Conclusions: Interobserver agreement on MRC sum‐score and handgrip strength in the ICU was very good. Agreement on “severe weakness” (MRC sum‐score <36) was excellent and supports its use in interventional studies. Agreement on “significant weakness” (MRC sum‐score <48) was good, but even better using the equivalent cut‐off in the upper limbs. It remains to be determined whether this may serve as a substitute. Muscle Nerve 45: 18–25, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531137 Fri, 23 Dec 2011 03:00:43 +0100 5531137 http://www.medworm.com/index.php?rid=5531136&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22227 Conclusions: Our findings suggest that hematoma formation from standard needle EMG is rare even in high‐risk muscles, which have been avoided historically in anticoagulated patients. Muscle Nerve 45: 9–12, 2012 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531136 Fri, 23 Dec 2011 03:00:40 +0100 5531136 http://www.medworm.com/index.php?rid=5531135&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23250 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531135 Fri, 23 Dec 2011 03:00:38 +0100 5531135 http://www.medworm.com/index.php?rid=5531134&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23251 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531134 Fri, 23 Dec 2011 03:00:36 +0100 5531134 http://www.medworm.com/index.php?rid=5531132&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23249 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531132 Fri, 23 Dec 2011 03:00:35 +0100 5531132 http://www.medworm.com/index.php?rid=5531131&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23248 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5531131 Fri, 23 Dec 2011 03:00:34 +0100 5531131 http://www.medworm.com/index.php?rid=5499811&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23275 Discussion:Exercise‐induced hemodynamic adjustment impairment in diabetic rats was associated with reduced cardiac vagal control. The vagal dysfunction was attenuated after aerobic exercise, reinforcing the positive role of this approach in the management of cardiovascular risk in diabetics. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5499811 Tue, 13 Dec 2011 05:00:00 +0100 5499811 http://www.medworm.com/index.php?rid=5499810&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23276 CONCLUSION:DT‐MRI can detect changes in human skeletal muscle structure following eccentric exercise. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5499810 Tue, 13 Dec 2011 05:00:00 +0100 5499810 http://www.medworm.com/index.php?rid=5491365&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23274 We describe a patient with congenital hypotonia, generalized weakness, elevated creatine kinase (CK) and normal brain imaging.Results:Histochemical analysis of the index case's muscle showed deficiency of glycosylated α‐dystroglycan and secondary merosin deficiency. Genetic testing revealed a novel mutation in exon 20 of the POMT1 gene.Discussion:Our patient's milder form of CMD adds to the emerging evidence of an expanding phenotype caused by POMT1 mutations. The histopathological findings of the muscle biopsy in this case support the need for careful clinical, genetic and histochemical diagnostic interpretation. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5491365 Thu, 08 Dec 2011 05:00:00 +0100 5491365 http://www.medworm.com/index.php?rid=5481602&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23265 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5481602 Mon, 05 Dec 2011 05:00:00 +0100 5481602 http://www.medworm.com/index.php?rid=5481601&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23271 ConclusionsThis is the first nation‐wide epidemiological study of seropositive MG that elucidates the geographical differences within a country. The incidence of seropositive MG did not vary significantly between the regions. Mid‐Norway tended to have a higher incidence, and North tended to have a lower incidence. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5481601 Mon, 05 Dec 2011 05:00:00 +0100 5481601 http://www.medworm.com/index.php?rid=5481600&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23270 Conclusions:Mutations in CAV3, and in particular p.V57M in CAV3, previously reported in isolated familial hyperCKemia, can be associated with electrical myotonia. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5481600 Mon, 05 Dec 2011 05:00:00 +0100 5481600 http://www.medworm.com/index.php?rid=5481599&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23269 ConclusionThe epineurium of the ulnar nerve can be measured with the use of HRUS, and it is often strikingly thickened in leprosy patients, especially in those with ulnar involvement. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5481599 Mon, 05 Dec 2011 05:00:00 +0100 5481599 http://www.medworm.com/index.php?rid=5481598&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23268 Conclusion:These results suggested that there is a fixed muscle combination, i.e. RF and the three vasti muscles, to perform low‐intensity sustained contraction in the human QF. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5481598 Mon, 05 Dec 2011 05:00:00 +0100 5481598 http://www.medworm.com/index.php?rid=5481597&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23267 Discussion:Standardized tests of muscle VRCs and responses to repetitive stimulation can provide consistent measures of membrane function and may encourage their wider use in clinical neurophysiology to investigate the pathophysiology of neuromuscular disorders. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5481597 Mon, 05 Dec 2011 05:00:00 +0100 5481597 http://www.medworm.com/index.php?rid=5472704&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23261 Discussion.Optimization of a HDD through exclusion of non‐acute cases results in an acceptable and practical database for passive surveillance of GBS. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5472704 Fri, 02 Dec 2011 05:00:00 +0100 5472704 http://www.medworm.com/index.php?rid=5472703&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23260 Conclusions:Our analysis suggests that: 1) the score can be summated to estimate an overall disease severity score; 2) the response options of the ten items are not significantly distorted; and, 3) the assigned weights of the response options are appropriate. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5472703 Fri, 02 Dec 2011 05:00:00 +0100 5472703 http://www.medworm.com/index.php?rid=5472702&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23259 Discussion.In PPS, possible neuropathic pain is associated with psychophysical and neurophysiological abnormalities suggestive of small fiber damage. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5472702 Fri, 02 Dec 2011 05:00:00 +0100 5472702 http://www.medworm.com/index.php?rid=5472701&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23258 CONCLUSIONS:Kurtosis seems to be a promising parameter for monitoring individuals who develop CTS. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5472701 Fri, 02 Dec 2011 05:00:00 +0100 5472701 http://www.medworm.com/index.php?rid=5510518&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23278 AbstractRecent findings highlight a pathological and functional convergence in amyotrophic lateral sclerosis (ALS) and amyotrophic lateral sclerosis with frontotemporal dementia (ALS‐FTD) at the level of protein recycling and disposal. Genes linked to rare cases of familial ALS and ALS‐FTD, like UBQLN2, OPTN, SQSTM1/p62 and VCP may converge onto a unifying pathogenic pathway and thereby provide novel therapeutic targets common to a spectrum of etiologically diverse forms of ALS and ALS‐FTD. Interactions between these genes need to be further explored to understand their common molecular pathways. Future efforts should be directed towards generation and characterization of in vivo models to dissect the pathogenic mechanisms of ALS and ALS‐FTD and the role of protein degradation path... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5510518 Thu, 01 Dec 2011 05:00:00 +0100 5510518 http://www.medworm.com/index.php?rid=5499809&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23277 Conclusions:QMUS in oral muscles is feasible in healthy children, adults and patients with DMD. These data show it is possibile to differentiate between healthy persons and patients with DMD. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5499809 Thu, 01 Dec 2011 05:00:00 +0100 5499809 http://www.medworm.com/index.php?rid=5491364&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23273 Discussion:The most effective and safest point for BoNT injection into adductor muscles appears to be between 35% and 50% from ASIS, where neuromuscular junctions are most densely distributed. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5491364 Thu, 01 Dec 2011 05:00:00 +0100 5491364 http://www.medworm.com/index.php?rid=5481596&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23266 Conclusions:An acute bout of RE increases SC content in young men at 24h and older women at 6 and 24h. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5481596 Thu, 01 Dec 2011 05:00:00 +0100 5481596 http://www.medworm.com/index.php?rid=5472700&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23257 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5472700 Thu, 01 Dec 2011 05:00:00 +0100 5472700 http://www.medworm.com/index.php?rid=5452967&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23256 Conclusions:Serum IgM binding to TS‐HDS is associated with painful, sensory > motor, polyneuropathies with an increased frequency of persistent hand discomfort, serum IgM M‐proteins, and capillary pathology. Serum IgM binding to TS‐HDS suggests a possible immune etiology underlying some otherwise idiopathic sensory polyneuropathies. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5452967 Tue, 29 Nov 2011 02:43:55 +0100 5452967 http://www.medworm.com/index.php?rid=5452968&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23255 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5452968 Sat, 26 Nov 2011 05:00:00 +0100 5452968 http://www.medworm.com/index.php?rid=5446298&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23252 DiscussionThe application of intra‐nerve and inter‐nerve CSA variability measures allowed us to quantify the heterogeneity of nerves and nerve segments and identify different US patterns in diverse immune‐related neuropathies. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5446298 Sat, 26 Nov 2011 02:27:12 +0100 5446298 http://www.medworm.com/index.php?rid=5446300&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23254 DiscussionFurther testing is needed to validate the use of the adjusted burst superimposition test in a neurologically impaired population. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5446300 Thu, 24 Nov 2011 05:00:00 +0100 5446300 http://www.medworm.com/index.php?rid=5446299&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23253 DISCUSSION: Although the prediction of time‐to‐exhaustion is an appealing research topic, these results suggest that it cannot be done solely from sEMG. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5446299 Thu, 24 Nov 2011 05:00:00 +0100 5446299 http://www.medworm.com/index.php?rid=5435962&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23247 Conclusions: We found that scFv‐DAF could bind specifically to TE671 cells, and it is significantly more potent at inhibiting complement deposition than the untargeted parent molecule DAF. scFv‐DAF may be a candidate for in vivo protection of the AChR in MG. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5435962 Wed, 23 Nov 2011 02:09:14 +0100 5435962 http://www.medworm.com/index.php?rid=5426846&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22336 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426846 Sun, 20 Nov 2011 02:24:13 +0100 5426846 http://www.medworm.com/index.php?rid=5426845&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22337 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426845 Sun, 20 Nov 2011 02:24:12 +0100 5426845 http://www.medworm.com/index.php?rid=5426843&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22237 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426843 Sun, 20 Nov 2011 02:24:11 +0100 5426843 http://www.medworm.com/index.php?rid=5426842&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22238 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426842 Sun, 20 Nov 2011 02:24:09 +0100 5426842 http://www.medworm.com/index.php?rid=5426841&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22221 AbstractIn this pilot study we use T2‐weighted magnetic resonance imaging (MRI) to identify possible peripheral nerve inflammation in 4 patients with diffuse chronic pain. In all 4 patients, there was an increase in median and ulnar nerve T2 signal intensity at the wrist (P < 0.05 vs. controls). Positive clinical signs of peripheral nerve mechanosensitivity combined with MRI findings suggest that these patients may have an underlying peripheral nerve pathology. Muscle Nerve, 2011 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426841 Sun, 20 Nov 2011 02:24:03 +0100 5426841 http://www.medworm.com/index.php?rid=5426840&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22235 In this study we investigate whether dystrophic intrinsic laryngeal muscles (ILM) from aged mdx mice show alterations in dystrophin–glycoprotein complex (DGC) components.Immunofluorescence and immunoblotting analyses of beta‐sarcoglycan, beta‐dystroglycan, and utrophin showed that aged ILM had a similar pattern of changes in aged affected muscles (diaphragm and limb), suggesting that aging leads to changes in utrophin and DGC proteins in dystrophic ILM that cannot be correlated with their protection from dystrophic change. Muscle Nerve, 2011 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426840 Sun, 20 Nov 2011 02:24:01 +0100 5426840 http://www.medworm.com/index.php?rid=5426839&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22224 Conclusions: These results suggest that contact inhibition after the proliferation stage may induce growth arrest via cell–cell communication through the expression of CDKI p21 and may be responsible for progressing cell fusion. Muscle Nerve 2011 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426839 Sun, 20 Nov 2011 02:24:00 +0100 5426839 http://www.medworm.com/index.php?rid=5426838&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22217 Conclusion: A sustained level of excitatory amino acid transporter protein 2 (EAAT2) in astrocytes of the PGC‐1α/G93A DL mice may contribute to neuronal protection. Muscle Nerve 2011 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426838 Sun, 20 Nov 2011 02:23:58 +0100 5426838 http://www.medworm.com/index.php?rid=5426837&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22211 Conclusions:These results indicate that EMG amplitude is a reliable measure of motor unit activation strategy during incremental cycle ergometry, whereas the EMG MPF was unreliable. Muscle Nerve 2011 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426837 Sun, 20 Nov 2011 02:23:57 +0100 5426837 http://www.medworm.com/index.php?rid=5426836&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22190 Conclusions:Stepwise statistical regression and mathematical transformation improve the distribution of normative data, but their practical impact for diagnosis of distal symmetrical polyneuropathy is small. Muscle Nerve 2011 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426836 Sun, 20 Nov 2011 02:23:47 +0100 5426836 http://www.medworm.com/index.php?rid=5426835&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22236 Conclusion: Our results suggest that exercise prior to statin treatment can protect against decrements in muscle function. Muscle Nerve 2011 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426835 Sun, 20 Nov 2011 02:23:45 +0100 5426835 http://www.medworm.com/index.php?rid=5426834&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22258 Conclusions:No specific pattern of US abnormalities was identified in this cohort of patients with POEMS syndrome. The lack of correlation between US and clinical findings may be secondary to the chronic nerve damage that is common in POEMS syndrome, where the diagnosis is often delayed. Muscle Nerve 2011 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426834 Sun, 20 Nov 2011 02:23:42 +0100 5426834 http://www.medworm.com/index.php?rid=5426833&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22177 This study focuses on the postsynaptic factors that influence the SF and how the SF is altered in myasthenia gravis. Muscle Nerve, 2011 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426833 Sun, 20 Nov 2011 02:23:39 +0100 5426833 http://www.medworm.com/index.php?rid=5426832&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22335 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426832 Sun, 20 Nov 2011 02:23:36 +0100 5426832 http://www.medworm.com/index.php?rid=5426831&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22334 (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426831 Sun, 20 Nov 2011 02:23:35 +0100 5426831 http://www.medworm.com/index.php?rid=5426817&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23231 This study examines the association between substance use, antiretrovirals, ethnicity and incident neuropathy in an HIV‐infected cohort.Methods:Data were obtained from the National NeuroAIDS Tissue Consortium (NNTC), an ongoing, prospective cohort started in 1998. Cox proportional hazards models were used to examine the association of substance use, demographics, neurotoxic antiretrovirals, and laboratory parameters with incident neuropathy in 636 participants who were neuropathy‐free at baseline.Results:The cumulative incidence of DSP was 41%. Substance use (p =.04), number of substances used (p=.04) and longer duration of HIV infection (p = 0.05) were associated with incident DSP, but demographic factors, use of neurotoxic antiretrovirals, and laboratory parameters were not.Discussio... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426817 Sun, 20 Nov 2011 02:21:12 +0100 5426817 http://www.medworm.com/index.php?rid=5426830&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23243 Conclusions:These results suggest that the degenerative and regenerative phases of muscle injury may be distinguished sonographically through differences in echogenicity, echotexture and, using Doppler ultrasound, differences in the degree of vascularization. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426830 Fri, 18 Nov 2011 05:00:00 +0100 5426830 http://www.medworm.com/index.php?rid=5426829&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23244 DISCUSSION:Strategies to address these unresolved issues are discussed as well as a detailed action plan. Physical activity © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426829 Fri, 18 Nov 2011 05:00:00 +0100 5426829 http://www.medworm.com/index.php?rid=5426828&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23245 AbstractThis review provides the reader with an overview of quality of life (QOL) and QOL measures in neuromuscular disorders. We discuss the characteristics of QOL measures used in neuromuscular research, highlighting differences between generic versus disease‐specific and global versus health‐related QOL instruments. The phenomenon of response shift is reviewed. Commonly used QOL instruments are reviewed for amyotrophic lateral sclerosis, muscle diseases, myasthenia gravis and polyneuropathy. We also review some of what is known about QOL for patients with these neuromuscular disorders. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426828 Fri, 18 Nov 2011 05:00:00 +0100 5426828 http://www.medworm.com/index.php?rid=5426827&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23246 Conclusion:The altered hand dynamics in CTS patients may have implications for the pathophysiology and clinical evaluation of CTS, and ultrasound‐based classification models may further support the diagnosis of CTS. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426827 Fri, 18 Nov 2011 05:00:00 +0100 5426827 http://www.medworm.com/index.php?rid=5426826&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23240 Discussion:Variation in MyHC isoform expression was apparent along the lengths of human EOMs. These results provide a basis for understanding the molecular mechanisms underlying the functional diversity of EOMs. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426826 Fri, 18 Nov 2011 05:00:00 +0100 5426826 http://www.medworm.com/index.php?rid=5426825&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23239 Discussion:Muscle MRI is an alternative tool to EMG in proximal, mild or chronic clinically diagnoes lower limb focal neuropathies. However it also seems prone to false positive results, particularly in proximal muscles. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426825 Fri, 18 Nov 2011 05:00:00 +0100 5426825 http://www.medworm.com/index.php?rid=5426824&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23238 This study was to assess the agreement between these procedures in a non‐random sample of volunteers.Methods:The evaluated procedures included electrodiagnostic tests of the sural nerve, monofilament testing of the great toe, a symptom survey and a body diagram. Kappa coefficients, sensitivity and specificity, using nerve conduction as a ‘gold standard’, were used to determine the agreement between various combinations of procedures.Results:Poor agreement (Kappa values: ‐0.12 ∼ 0.44) and sensitivity (sensitivity<30%) were found for all combinations of symptoms and monofilament results in comparison with sural peak latency and amplitude.Discussion:Overall, the results demonstrated a low discriminatory power for the screening procedures for identifying persons with impaired sura... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426824 Fri, 18 Nov 2011 05:00:00 +0100 5426824 http://www.medworm.com/index.php?rid=5426823&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23237 DiscussionSupraorbital SNAPs can be recorded in all normals and used as a quantitative measure of the functioning large fibers in the nerve. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426823 Fri, 18 Nov 2011 05:00:00 +0100 5426823 http://www.medworm.com/index.php?rid=5426822&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23236 Discussion:Baseline QMGS, AChRAb positivity and SFEMG parameters were more abnormal in patients who responded to treatment. Using multivariate regression, baseline QMGS remained as the only significant independent predictor of response. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426822 Fri, 18 Nov 2011 05:00:00 +0100 5426822 http://www.medworm.com/index.php?rid=5426821&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23235 AbstractThe term thoracic outlet syndrome (TOS) refers to a heterogeneous group of disorders, all of which have in common compression of one or more neurovascular elements at some point within the thoracic outlet. Of the 5 disorders comprising this group, 4 have all of the features expected of a syndrome—a recognized constellation of clinical features, an anatomic derangement accounting for these features, and a method of testing that identifies the anatomic derangement. Consequently, their recognition and management are relatively straightforward. Conversely, 1 of these 5 disorders (nonspecific TOS) lacks these correlations. It has generated considerable debate in the literature and caused some experts to doubt its existence altogether. The primary focus of this manuscript is on the neu... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426821 Fri, 18 Nov 2011 05:00:00 +0100 5426821 http://www.medworm.com/index.php?rid=5426820&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23234 AbstractStiff Person Syndrome (SPS) is a disabling autoimmune CNS disorder characterized by progressive muscle rigidity and gait impairment with superimposed painful spasms that involve axial and limb musculature, triggered by heightened sensitivity to external stimuli. Impaired synaptic GABAergic inhibition resulting from intrathecal B‐cell‐mediated clonal synthesis of autoantibodies against various presynaptic and synaptic proteins in the inhibitory neurons of the brain and spinal cord is believed to be an underlying pathogenic mechanism. SPS is most often idiopathic, but it can occur as a paraneoplastic condition. Despite evidence that anti‐GAD and related autoantibodies impair GABA synthesis, the exact pathogenic mechanism of SPS is not fully elucidated. The strong association wi... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426820 Fri, 18 Nov 2011 05:00:00 +0100 5426820 http://www.medworm.com/index.php?rid=5426819&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23233 In this study, we evaluate whether electrical impedance myography (EIM) can detect disease progression in SMA compared to a group of healthy children of similar age.Methods:Twenty‐eight children with SMA and 20 normals underwent repeated EIM testing in four muscles at regular intervals for up to 3 years. An average rate of change of EIM was calculated for each subject and normalized to subcutaneous fat thickness and muscle girth.Results:Multiple EIM parameters showed change in normal subjects over a mean of 16.7 months; however, no change was found in SMA patients over this period.Discussion:These results indicate that EIM can detect non‐mass‐dependent muscle maturation in healthy children. In contrast, the muscle of children with SMA as measured by EIM is virtually static, showing e... Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426819 Fri, 18 Nov 2011 05:00:00 +0100 5426819 http://www.medworm.com/index.php?rid=5426818&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23232 Conclusion:The overlap of efferent supply to the whisker pad must be considered when studying facial nerve regeneration in the rat facial nerve model. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5426818 Fri, 18 Nov 2011 05:00:00 +0100 5426818 http://www.medworm.com/index.php?rid=5415330&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.23241 Conclusion:The increase in serum S100B reaffirms pathological changes across the spectrum of WNV disease. The elevated S100B in over one‐third of WNV fever cases implies that neuroinvasion occurs in a much higher proportion of patients than anticipated by clinical and epidemiological data. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5415330 Wed, 16 Nov 2011 05:00:00 +0100 5415330 http://www.medworm.com/index.php?rid=5371893&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22344 Discussion.These results suggest that except for neurogenic factors, the variability of muscle fiber diameters also leads to the formation of MUPs with satellites. This variability seems to be responsible for the differences in the shape of the main and satellite MUP components in ALS and SMA. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5371893 Thu, 03 Nov 2011 04:00:00 +0100 5371893 http://www.medworm.com/index.php?rid=5371892&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22343 Discussion.RyR1Y522S/wt mice can run without experiencing rhabdomyolysis, and their inability to adapt to training appears to stem from intrinsic enhancement of mitochondrial enzymes and fatigue resistance. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5371892 Thu, 03 Nov 2011 04:00:00 +0100 5371892 http://www.medworm.com/index.php?rid=5371891&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22342 Discussion:As a discrete biomarker, edema may be useful for following the clinical course of FSHD. Future work toward optimizing measurement is discussed. © 2011 Wiley‐Liss, Inc. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5371891 Thu, 03 Nov 2011 04:00:00 +0100 5371891 http://www.medworm.com/index.php?rid=5371890&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22341 CONCLUSION:DQEMG could indicate the severity of muscular dystrophy involvement, as changes in MUP morphology reflected the progressive nature of the disease. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5371890 Thu, 03 Nov 2011 04:00:00 +0100 5371890 http://www.medworm.com/index.php?rid=5371889&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22340 Discussion:If the first 12 SFEMG pairs have normal jitter, the study can be terminated and interpreted as normal. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5371889 Thu, 03 Nov 2011 04:00:00 +0100 5371889 http://www.medworm.com/index.php?rid=5371888&cid=s_33606_49_f&fid=33606&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fmus.22339 Conclusion:This study revealed significant length‐dependent changes in median nerve excitability. We suggest that these changes probably reflect intrinsic changes within the median nerve. (Source: Muscle and Nerve) Muscle and Nerve journals http://www.medworm.com/rss/comments.php?id=5371888 Thu, 03 Nov 2011 04:00:00 +0100 5371888