MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nanomedicine' source. Tue, 02 Mar 2010 18:16:04 +0100 http://www.medworm.com/index.php?rid=3115629&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025457%26dopt%3DAbstract Authors: Martin CR PMID: 20025457 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115629 Wed, 23 Dec 2009 23:47:14 +0100 3115629 http://www.medworm.com/index.php?rid=3115628&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025458%26dopt%3DAbstract Authors: McCarron PA, Faheem AM PMID: 20025458 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115628 Wed, 23 Dec 2009 23:47:11 +0100 3115628 http://www.medworm.com/index.php?rid=3115627&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025459%26dopt%3DAbstract News & views in ... Nanomedicine. Nanomed. 2010 Jan;5(1):7-9 Authors: PMID: 20025459 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115627 Wed, 23 Dec 2009 23:47:08 +0100 3115627 http://www.medworm.com/index.php?rid=3115626&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025460%26dopt%3DAbstract Conclusion: This strategy appears a very promising one towards the development of a liquid aqueous EFV formulation for the improved pediatric HIV pharmacotherapy. PMID: 20025460 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115626 Wed, 23 Dec 2009 23:47:01 +0100 3115626 http://www.medworm.com/index.php?rid=3115625&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025461%26dopt%3DAbstract Conclusion: Riluzole-loaded solid lipid nanoparticles showed colloidal size and high drug loading, a greater efficacy than free riluzole in rats, a higher capability to carry the drug into the brain and a lower indiscriminate biodistribution. PMID: 20025461 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115625 Wed, 23 Dec 2009 23:46:57 +0100 3115625 http://www.medworm.com/index.php?rid=3115624&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025462%26dopt%3DAbstract Conclusions: AgNPs can be mycosynthesized extracellularly using A. clavatus as the fungal system, which is highly advantageous over chemical synthesis not only because it can be synthesized on a large scale, but because of the ease of downstream processing and its biomedical application in antimicrobial activity. PMID: 20025462 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115624 Wed, 23 Dec 2009 23:46:52 +0100 3115624 http://www.medworm.com/index.php?rid=3115623&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025463%26dopt%3DAbstract Conclusion: This finding increases the feasibility of using this bone marrow-specific drug-delivery system for clinical applications. PMID: 20025463 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115623 Wed, 23 Dec 2009 23:46:47 +0100 3115623 http://www.medworm.com/index.php?rid=3115622&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025464%26dopt%3DAbstract Conclusion: The results suggest p53 activation in Pt-NP-treated cells due to genotoxic stress, with subsequent activation of p21 leading to a proliferating cell nuclear antigen-mediated growth arrest and apoptosis. This study recommends development of Pt-NP-based anticancer agents by appropriate surface modifications to augment its innate anticancer activity. PMID: 20025464 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115622 Wed, 23 Dec 2009 23:46:42 +0100 3115622 http://www.medworm.com/index.php?rid=3115621&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025465%26dopt%3DAbstract Conclusion: The 'oscillating' effect of an AC magnetic field greatly improves the ability to transport MNPs within soft media by decreasing the effective viscosity of the gel. PMID: 20025465 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115621 Wed, 23 Dec 2009 23:46:37 +0100 3115621 http://www.medworm.com/index.php?rid=3115620&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025466%26dopt%3DAbstract Conclusion: The rapid and easy manipulation of encoded carriers using magnetic properties could be used to develop promising suspension arrays for portable bioassays. PMID: 20025466 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115620 Wed, 23 Dec 2009 23:46:32 +0100 3115620 http://www.medworm.com/index.php?rid=3115619&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025467%26dopt%3DAbstract In conclusion, phagocytosis appears to be the internalization pathway for CNT aggregates, bundles, cluster or single dispersed nanotubes 1 microm or more in length; endocytosis is the internalization mechanism for nanotubes forming supramolecular structures; and diffusion is the internalization mechanism for submicron CNTs that do not form supramolecular complexes. This information may be relevant to the rational design of CNT-based carriers for cell therapy. PMID: 20025467 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115619 Wed, 23 Dec 2009 23:46:26 +0100 3115619 http://www.medworm.com/index.php?rid=3115618&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025468%26dopt%3DAbstract Authors: Kubinová S, Syková E The use of nanotechnology in cell therapy and tissue engineering offers promising future perspectives for brain and spinal cord injury treatment. Stem cells have been shown to selectively target injured brain and spinal cord tissue and improve functional recovery. To allow cell detection, superparamagnetic iron-oxide nanoparticles can be used to label transplanted cells. MRI is then a suitable method for the in vivo tracking of grafted cells in the host organism. CNS, and particularly spinal cord, injury is accompanied by tissue damage and the formation of physical and biochemical barriers that prevent axons from regenerating. One aspect of nanomedicine is the development of biologically compatible nanofiber scaffolds that mimic the structure of ... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115618 Wed, 23 Dec 2009 23:46:23 +0100 3115618 http://www.medworm.com/index.php?rid=3115617&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025469%26dopt%3DAbstract Authors: Lin MM, Kim HH, Kim H, Dobson J, Kim do K The advanced fabrication and surface engineering of superparamagnetic iron oxide nanoparticles (SPIONs) could offer excellent physiochemical features for noninvasive tumor imaging and drug delivery. The key issues of realization of maximized selective cancer targeting of SPIONs are minimization of uptake by macrophages, preferential binding to cancerous cells over neighboring normal cells, visualization of tumor cells prior to and after treatment and triggered drug release into target cells in a controlled fashion. In this article, we summarize the current status of fabrication of multifunctional SPION-based nanodevices specially designed for cancer-oriented diagnosis and therapy, with a focus on potential malignancy-targeting ligands'... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115617 Wed, 23 Dec 2009 23:46:17 +0100 3115617 http://www.medworm.com/index.php?rid=3115616&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025470%26dopt%3DAbstract Authors: Chowdhury N As the market for nanomedicines in the EU is growing, the development of regulatory guidance in this area assumes priority. Currently, the nanomedicine market is poised at a critical stage wherein clear regulatory guidance is imperative in providing for clarity and legal certainty to manufacturers of nanomedicine. The regulation of the pharmaceutical sector in the EU has witnessed several developments and innovations guided by the philosophy of single market and balancing the principle of ensuring high public health protection and safety of medicines. Both the pediatric and the advanced therapies medicinal products (ATMP) regimes offer important regulatory guidance that could be adopted for the regulation of nanomedicines in the EU. PMID: 20025470 [PubMed - in ... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115616 Wed, 23 Dec 2009 23:46:14 +0100 3115616 http://www.medworm.com/index.php?rid=3115615&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025471%26dopt%3DAbstract This report describes the 'programmable nano-bio-chip' with potential to bridge the significant scientific, technology and clinical gaps through the creation of a diagnostic platform to measure the molecules of life. This approach, with results at the point-of-care, possesses capabilities for measuring such diverse analyte classes as cells, proteins, DNA and small molecules in the same compact device. Applications such as disease diagnosis and prognosis for areas including cancer, heart disease and HIV are described. New diagnostic panels are inserted as 'plug and play' elements into the modular platform with universal assay operating systems and standard read out sequences. The nano-bio-chip ensemble exhibits excellent analytical performance and cost-effectiveness with extensive validatio... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115615 Wed, 23 Dec 2009 23:46:09 +0100 3115615 http://www.medworm.com/index.php?rid=3115614&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20025472%26dopt%3DAbstract Authors: PMID: 20025472 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3115614 Wed, 23 Dec 2009 23:46:06 +0100 3115614 http://www.medworm.com/index.php?rid=3061802&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958219%26dopt%3DAbstract Authors: Kedmi R, Peer D PMID: 19958219 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061802 Tue, 01 Dec 2009 00:00:00 +0100 3061802 http://www.medworm.com/index.php?rid=3061801&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958220%26dopt%3DAbstract Authors: Muthu MS, Feng SS PMID: 19958220 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061801 Tue, 01 Dec 2009 00:00:00 +0100 3061801 http://www.medworm.com/index.php?rid=3061800&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958221%26dopt%3DAbstract News & views in ... Nanomedicine. Nanomed. 2009 Dec;4(8):861-3 Authors: PMID: 19958221 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061800 Tue, 01 Dec 2009 00:00:00 +0100 3061800 http://www.medworm.com/index.php?rid=3061799&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958222%26dopt%3DAbstract Authors: Feng SS PMID: 19958222 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061799 Tue, 01 Dec 2009 00:00:00 +0100 3061799 http://www.medworm.com/index.php?rid=3061798&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958223%26dopt%3DAbstract Authors: Weston D, Bontoux T Located in the London neighborhoods of Bloomsbury and South Kensington, the London Centre for Nanotechnology is a UK-based multidisciplinary research center that operates at the forefront of science and technology. It is a joint venture between two of the world's leading institutions, UCL and Imperial College London, uniting their strong capabilities in the disciplines that underpin nanotechnology: engineering, the physical sciences and biomedicine. The London Centre for Nanotechnology has a unique operating model that accesses and focuses the combined skills of the Departments of Chemistry, Physics, Materials, Medicine, Electrical and Electronic Engineering, Mechanical Engineering, Chemical Engineering, Biochemical Engineering and Earth Sciences across the... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061798 Tue, 01 Dec 2009 00:00:00 +0100 3061798 http://www.medworm.com/index.php?rid=3061797&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958224%26dopt%3DAbstract Authors: Krukemeyer M, Wagner W, Jakobs M, Krenn V The expression 'magnetic drug targeting' is understood as meaning the targeted administration of a drug, for example, a cytostatic, with the intention of optimizing the local therapeutic effect. A magnetic field strength of 0.6 T is applied externally to the body. Iron oxides are administered intravasally into a vein. Cytostatics are bonded to the iron oxides. This form of administration, also known as sluicing, is particularly suitable for cytostatics, since the intention is to achieve a high concentration of the cytostatic at the target site (site of the tumor), but to minimize the harmful effect in the rest of the tissue. A reduction in tumor volume under the magnetic field and in the liver of 45-90% has been detected by MRI. PM... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061797 Tue, 01 Dec 2009 00:00:00 +0100 3061797 http://www.medworm.com/index.php?rid=3061796&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958225%26dopt%3DAbstract Conclusion: We believe this finding could lead to the development of new cancer therapies by carefully selecting the cytostatic drugs and nanostructural materials that, in combination, may provide synergistic curative rates. PMID: 19958225 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061796 Tue, 01 Dec 2009 00:00:00 +0100 3061796 http://www.medworm.com/index.php?rid=3061795&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958226%26dopt%3DAbstract Conclusion: The Tam-HPbetaCD nanoassembly entered the cell owing to enhanced permeability and retention property of tumor cell and antiestrogenic Tam and, therefore, resulted in excellent anticancer efficacy in the ovarian cancer cell line. PMID: 19958226 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061795 Tue, 01 Dec 2009 00:00:00 +0100 3061795 http://www.medworm.com/index.php?rid=3061794&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958227%26dopt%3DAbstract Conclusion: These results support the continued development of macrophage-mediated nanoART carriage for HIV-1 disease. PMID: 19958227 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061794 Tue, 01 Dec 2009 00:00:00 +0100 3061794 http://www.medworm.com/index.php?rid=3061793&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958228%26dopt%3DAbstract Conclusion: The chemical synthesis procedure developed to obtain VIP-functionalized silver nanoparticles rendered functional products, in terms of biological activity. The two alternative orientations designed, reduced the constraints for chemical synthesis that depends on the nanosurface to be functionalized. Our study provides, for the first time, a proof of principle to enhance the therapeutic potential of VIP with the valuable properties of metal nanoparticles for imaging, targeting and drug delivery. PMID: 19958228 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061793 Tue, 01 Dec 2009 00:00:00 +0100 3061793 http://www.medworm.com/index.php?rid=3061792&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958229%26dopt%3DAbstract Conclusion: This model system may also allow study of nanosized vesicles derived from donor tissue, including any microbes present, and could provide a useful tool for in vitro investigation of nanoparticle biofilm formation. PMID: 19958229 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061792 Tue, 01 Dec 2009 00:00:00 +0100 3061792 http://www.medworm.com/index.php?rid=3061791&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958230%26dopt%3DAbstract Conclusion: NiTi alloy is widely used for many medical appliances; hence, this unique friction-reducing coating could be implemented to provide better manipulation and lower piercing rates. PMID: 19958230 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061791 Tue, 01 Dec 2009 00:00:00 +0100 3061791 http://www.medworm.com/index.php?rid=3061790&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958231%26dopt%3DAbstract Authors: Jia H, Titmuss S In this article, we focus on nanoparticles that have been functionalized by polymers. We draw our examples from nanoparticle systems that have found biomedical and therapeutic applications. Our aim is to highlight the physical principles that might explain why these systems have been found to be successful in biomedical applications and to highlight other physical properties that might lead to new applications. We consider viruses, gold nanoparticles, magnetic nanoparticles and quantum dots, focussing attention on the ways in which functionalization by polymers has been used to alter the physical characteristics of the particular nanoparticle to improve its function as a possible therapy. In the case of viral vectors, polymer functionalization tunes the biocom... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061790 Tue, 01 Dec 2009 00:00:00 +0100 3061790 http://www.medworm.com/index.php?rid=3061789&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958232%26dopt%3DAbstract This article gives a perspective from two sides. From the point of view of a materials scientist, it will be pointed out what new materials will be possible, how they will be designed and which properties they could offer for diagnosis and treatment. From the point of view of a medical doctor, it will be pointed out which properties are actually desired and what materials are hoped for practical applications. The two different points of view indicate that, although sophisticated materials with advanced novel properties will be available in the future, they do not automatically match the requirements and demands of clinicians. The discussion is centerd around one example, multifunctional polyelectrolyte capsules, which might act as a 'nanosubmarine' for in vivo sensing and delivery, which i... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061789 Tue, 01 Dec 2009 00:00:00 +0100 3061789 http://www.medworm.com/index.php?rid=3061788&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958233%26dopt%3DAbstract Authors: Rahn H, Odenbach S Computed tomography is a widely used technique to study the inner structure of opaque samples using the material-dependent attenuation of x-rays. Microcomputed tomography follows the same principles used for conventional medical CT scanners, but improves the spatial resolution to a few micrometers. As an example for the application of x-ray microtomography, the study of the 3D biodistribution of magnetic nanoparticles in tumoral tissue after minimal invasive cancer therapy, which is one of the crucial factors for this kind of therapy, is presented in this article. In particular, the possibilities and problems resulting from the use of different sources of radiation - synchrotron and x-ray tubes, respectively - will be discussed. PMID: 19958233 [PubMed - ... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061788 Tue, 01 Dec 2009 00:00:00 +0100 3061788 http://www.medworm.com/index.php?rid=3061787&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19958234%26dopt%3DAbstract Authors: PMID: 19958234 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=3061787 Tue, 01 Dec 2009 00:00:00 +0100 3061787 http://www.medworm.com/index.php?rid=2912993&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839803%26dopt%3DAbstract Authors: McCarthy JR PMID: 19839803 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912993 Wed, 30 Sep 2009 23:00:00 +0100 2912993 http://www.medworm.com/index.php?rid=2912992&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839804%26dopt%3DAbstract News & views in ... Nanomedicine. Nanomed. 2009 Oct;4(7):697-700 Authors: PMID: 19839804 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912992 Wed, 30 Sep 2009 23:00:00 +0100 2912992 http://www.medworm.com/index.php?rid=2912991&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839805%26dopt%3DAbstract Authors: Kim JS, Low V, Richards J PMID: 19839805 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912991 Wed, 30 Sep 2009 23:00:00 +0100 2912991 http://www.medworm.com/index.php?rid=2912990&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839806%26dopt%3DAbstract Authors: Löffler B The 2nd European Conference for Clinical Nanomedicine (European CLINAM Conference) was held in April 2009 in Basel, Switzerland, and is the annual scientific conference of the European Foundation for Clinical Nanomedicine (European CLINAM Foundation) and the European Society for Nanomedicine. The meeting brings together clinicians and nanoscientists with the common vision of applying nanoscience methods, tools and materials for the benefit of the patient. This year's topics were unsolved medical problems in the fields of cardiology, oncology, neurology/neurosurgery, dermatology, orphan diseases, orthopedics and implants, hematology, inflammatory and infections diseases, and ear and eye diseases. Over the course of 3 days, 90 presentations by outstanding experts ... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912990 Wed, 30 Sep 2009 23:00:00 +0100 2912990 http://www.medworm.com/index.php?rid=2912989&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839807%26dopt%3DAbstract Authors: Moore R, Battaglia G The Institute of Nanotechnology, in collaboration with the University of Sheffield, organized this 1-day interactive workshop held at the Kroto Institute, Sheffield University North Campus, Sheffield, UK. The workshop provided a showcase of innovative and exciting new medical nanotechnologies. The topics addressed included diagnostics and imaging, tissue engineering, polymer therapeutics and drug delivery, and drug discovery and screening. The workshop was attended by clinicians, medical researchers, industry experts, healthcare managers, academics and students. The workshop was divided into four sessions: regenerative medicine and smart materials; innovations in medical diagnostics and sensing; new techniques for drug discovery and drug delivery; and nove... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912989 Wed, 30 Sep 2009 23:00:00 +0100 2912989 http://www.medworm.com/index.php?rid=2912988&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839808%26dopt%3DAbstract Conclusion: Incorporation of DAS in niosomes enhances its antifungal efficacy. Further studies are needed to optimize the current findings to develop an efficient nature-derived alternative antifungal therapeutic strategy. PMID: 19839808 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912988 Wed, 30 Sep 2009 23:00:00 +0100 2912988 http://www.medworm.com/index.php?rid=2912987&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839809%26dopt%3DAbstract Conclusion: Effects of bovine-derived and hydroxyapatite NPs on basal release of ATP were both time and concentration dependent. These results suggest that biologic NPs modulate both platelet aggregation and secretion. Biologically derived NPs could modify platelet responses within the vasculature, thereby reducing blood coagulability and the vascular response to injury. PMID: 19839809 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912987 Wed, 30 Sep 2009 23:00:00 +0100 2912987 http://www.medworm.com/index.php?rid=2912986&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839810%26dopt%3DAbstract Authors: Li X, Radomski A, Corrigan OI, Tajber L, De Sousa Menezes F, Endter S, Medina C, Radomski MW Aim: The increasing interest in biodegradable nanoparticles containing biomaterials such as poly(D,L-lactide-co-glycolide) (PLGA) and chitosan for drug delivery raises issues regarding the blood compatibility of these nanoparticles, since some nanoparticles, including carbon nanoparticles, can affect human platelet aggregation and cause vascular thrombosis. Therefore, the aim of this work was to investigate the effect of polymeric nanoparticles on human platelet function by measuring aggregation and receptor expression in vitro. Materials & method: PLGA, chitosan-PLGA and a series of chitosan nanoparticles were prepared by the single emulsion technique and ionotropic gelation metho... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912986 Wed, 30 Sep 2009 23:00:00 +0100 2912986 http://www.medworm.com/index.php?rid=2912985&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839811%26dopt%3DAbstract Conclusion: These results suggest that the availability of mono-unsaturated fatty acids, such as oleic acid, in different cells could significantly alter nanoparticle uptake and localization, which can in turn affect the functions of cells and tissues coexposed to nanoparticles. PMID: 19839811 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912985 Wed, 30 Sep 2009 23:00:00 +0100 2912985 http://www.medworm.com/index.php?rid=2912984&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839812%26dopt%3DAbstract Conclusion: Z-contrast STEM imaging provides a means for direct visualization of heavy metal containing molecules (i.e., cisplatin) attached to surfaces of carbon SWNTs along with distribution and quantitation. PMID: 19839812 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912984 Wed, 30 Sep 2009 23:00:00 +0100 2912984 http://www.medworm.com/index.php?rid=2912983&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839813%26dopt%3DAbstract Conclusion: Among the various types of lyoprotectants (natural and synthetic) examined, sucrose proved to be very effective in reducing the size of freeze-dried nanoparticles on redispersion without significant change in surface charge of nanoparticles. Finally, the in vitro release kinetics of BSA from nanoparticles of different molecular weights of chitosan, with and without sucrose, was evaluated and found to depend upon the molecular weight of chitosan. PMID: 19839813 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912983 Wed, 30 Sep 2009 23:00:00 +0100 2912983 http://www.medworm.com/index.php?rid=2912982&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839814%26dopt%3DAbstract Authors: Herrmann IK, Grass RN, Stark WJ The rapidly growing applications of nanomagnets in magnetic drug delivery and separation in clinical diagnostics require strong and reliable magnetic vehicles. Strength conveys rapid processing, high delivery/targeting yield and rapid results when used in clinics. Reliability enables recycling of nanomagnets, regulatory-conforming drug formulations and efficient use of (expensive) antibodies in diagnostics, combined with reduced leaching (reagent loss). The present work illustrates how metal-based nanomagnets provide a two-three-times stronger magnetic particle than conventional magnetite-based materials. Ligands, antibodies or drugs can be anchored to such carbon/metal core/shell nanomagnets over covalent, hydrolysis-resistant carbon-carbon bon... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912982 Wed, 30 Sep 2009 23:00:00 +0100 2912982 http://www.medworm.com/index.php?rid=2912981&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839815%26dopt%3DAbstract Authors: Barakat NS Magnetic nanoparticles are attractive targets owing to their unique characteristics that are not shared by bulk materials. Magnetic particles, ranging from nanometer-sized to 1 microm in size, are being used in an increasing number of medical applications. The important properties of magnetic particles for medical applications are nontoxicity, biocompatiblilty, injectability and high-level accumulation in the target tissue or organ. Magnetic nanoparticles modified with organic molecules have been widely used for biotechnological and biomedical applications as their properties can be magnetically controlled by applying an external magnetic field. They offer high potential for numerous biomedical applications, such as cell separation, automated DNA extraction, gene ta... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912981 Wed, 30 Sep 2009 23:00:00 +0100 2912981 http://www.medworm.com/index.php?rid=2912980&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839816%26dopt%3DAbstract This article is focused on the optical generation and detection of photothermal vapor bubbles around plasmonic nanoparticles. We report physical properties of such plasmonic nanobubbles and their biomedical applications as cellular probes. Our experimental studies of gold nanoparticle-generated photothermal bubbles demonstrated the selectivity of photothermal bubble generation, amplification of optical scattering and thermal insulation effect, all realized at the nanoscale. The generation and imaging of photothermal bubbles in living cells (leukemia and carcinoma culture and primary cancerous cells), and tissues (atherosclerotic plaque and solid tumor in animal) demonstrated a noninvasive highly sensitive imaging of target cells by small photothermal bubbles and a selective mechanical, non... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912980 Wed, 30 Sep 2009 23:00:00 +0100 2912980 http://www.medworm.com/index.php?rid=2912979&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19839817%26dopt%3DAbstract Authors: PMID: 19839817 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2912979 Wed, 30 Sep 2009 23:00:00 +0100 2912979 http://www.medworm.com/index.php?rid=2692371&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19663585%26dopt%3DAbstract Authors: Howard KA PMID: 19663585 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2692371 Fri, 31 Jul 2009 23:00:00 +0100 2692371 http://www.medworm.com/index.php?rid=2692370&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19663586%26dopt%3DAbstract Authors: Thomson H, Lotery A PMID: 19663586 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2692370 Fri, 31 Jul 2009 23:00:00 +0100 2692370 http://www.medworm.com/index.php?rid=2692369&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19663587%26dopt%3DAbstract Authors: Dusinska M, Dusinska M, Fjellsbø L, Magdolenova Z, Rinna A, Runden Pran E, Bartonova A, Heimstad E, Harju M, Tran L, Ross B, Juillerat L, Halamoda Kenzaui B, Marano F, Boland S, Guadaginini R, Saunders M, Cartwright L, Carreira S, Whelan M, Kelin Ch, Worth A, Palosaari T, Burello E, Housiadas C, Pilou M, Volkovova K, Tulinska J, Kazimirova A, Barancokova M, Sebekova K, Hurbankova M, Kovacikova Z, Knudsen L, Poulsen M, Mose T, Vilà M, Gombau L, Fernandez B, Castell J, Marcomini A, Pojana G, Bilanicova D, Vallotto D PMID: 19663587 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2692369 Fri, 31 Jul 2009 23:00:00 +0100 2692369 http://www.medworm.com/index.php?rid=2692368&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19663588%26dopt%3DAbstract News & views in ... Nanomedicine. Nanomed. 2009 Aug;4(6):609-11 Authors: PMID: 19663588 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2692368 Fri, 31 Jul 2009 23:00:00 +0100 2692368 http://www.medworm.com/index.php?rid=2692367&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19663589%26dopt%3DAbstract Authors: Ross L, Riehle M, McNamara L, Burchmore R, Dalby M, McMurray R, Gadegaard N, Ahmed S, Tsimbouri P PMID: 19663589 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2692367 Fri, 31 Jul 2009 23:00:00 +0100 2692367 http://www.medworm.com/index.php?rid=2692366&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19663590%26dopt%3DAbstract Authors: Tasciotti E, Sakamoto J, Ferrari M Emerging trends from nanotechnology on a globalized scale have created the need for a platform to discuss advances and share developments in this fast growing field. A conference was held to attract a vast number of scientists, representatives from nanotechnology vendor companies, and a diverse array of investors, businessmen and industry participants. The scope of the meeting was to discuss and share developments, innovations and research in the growing, but still emerging science of nanotechnology. The thrust of nanotechnology towards the development of personalized medicine, along with the enforced partnership between the Alliance for NanoHealth (ANH) and the US FDA to solve the issues of safety and approval of nanotechnology-based product... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2692366 Fri, 31 Jul 2009 23:00:00 +0100 2692366 http://www.medworm.com/index.php?rid=2692365&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19663591%26dopt%3DAbstract This study examined HBPL and LNCs for their cellular uptake and possible toxicity in vitro and in vivo as the first step in developing novel nanosized multifunctional carriers. Method: Having incubated HBPL and LNCs with fibroblasts, nanoparticle uptake and cell viability were determined by confocal laser scanning microscopy, fluorescence measurements and neutral red staining. In vivo, electrophysiology, confocal laser scanning microscopy and cytocochleograms were performed for nanoparticle detection and also toxicity studies after intracochlear application. Results: Both nanoparticles were detectable in the fibroblasts' cytoplasm without causing cytotoxic effects. After in vivo application they were visualized in cochlear cells, which did not lead to a change in hearing threshold or loss ... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2692365 Fri, 31 Jul 2009 23:00:00 +0100 2692365 http://www.medworm.com/index.php?rid=2692364&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19663592%26dopt%3DAbstract Authors: Amin RM, Mohamed MB, Ramadan MA, Verwanger T, Krammer B Background & aim: Nanomaterials are the leading requirement of the rapidly developing field of nanomedicine and bionanotechnology, and in this respect, nanotoxicology research is gaining great importance. In the field of infections, nanoparticles are being utilized as therapeutic tools against microbes, thus understanding the properties of nanoparticles and their effect on microbes is essential prior to clinical application. The aim of this study was to evaluate a microplate-based assay for monitoring the toxicity of silver and gold nanoparticles on bacteria. Method: Escherichia coli, a Gram-negative bacteria, and Staphylococcus capitis, a Gram-positive bacteria, were exposed to different concentrations of gold and si... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2692364 Fri, 31 Jul 2009 23:00:00 +0100 2692364 http://www.medworm.com/index.php?rid=2692363&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19663593%26dopt%3DAbstract This article describes strategies for achieving fluorescence enhancement in optical biochips. Two strategies are discussed: plasmonic enhancement, which is due to the localized surface plasmon resonance of metal nanostructures that are adjacent to the fluorescent labels in optical immunoassays; and the use of high-brightness silica nanoparticles as enhanced labels. We present a review of the state-of-the-art in both areas, including synthesis techniques for the metal and silica nanoparticles and the use of the nanoparticles in optical immunoassays. Data are presented that highlight the key design parameters which influence the level of enhancement and model assay data are presented that illustrate potential enhancements in assay performance. PMID: 19663593 [PubMed - in process] (Source... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2692363 Fri, 31 Jul 2009 23:00:00 +0100 2692363 http://www.medworm.com/index.php?rid=2692362&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19663594%26dopt%3DAbstract This article will focus on recent advancements in the design of stimulus-responsive targeted nanomicelles loaded with anticancer drugs to fulfill the challenges associated with cancer cells (e.g., multidrug resistance) for the effective treatment of cancer. The significant toxicity issues and a possible future perspective associated with nanomicelles are also discussed here. PMID: 19663594 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2692362 Fri, 31 Jul 2009 23:00:00 +0100 2692362 http://www.medworm.com/index.php?rid=2692361&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19663595%26dopt%3DAbstract Authors: Park MV, Lankveld DP, van Loveren H, de Jong WH Nanotechnology applications already on the market or in development promise great benefits for humans as well as the environment. Simultaneously, the pressure to advance the development of fast methods for evaluating the potential risks of increased human exposure to nanomaterials is augmented. One way forward would be to enhance the role of in vitro toxicity studies in risk assessment procedures of nanomaterials. However, to maximize the use of in vitro assays for this purpose, their values and limitations need to be revealed. Even in risk assessment frameworks for regular chemicals, in vitro studies play a minor role. A comparative analysis of published in vitro data with nanomaterials demonstrates that there are a number of is... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2692361 Fri, 31 Jul 2009 23:00:00 +0100 2692361 http://www.medworm.com/index.php?rid=2692360&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19663596%26dopt%3DAbstract Authors: PMID: 19663596 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2692360 Fri, 31 Jul 2009 23:00:00 +0100 2692360 http://www.medworm.com/index.php?rid=2573665&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572812%26dopt%3DAbstract Authors: Bhogal N PMID: 19572812 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2573665 Tue, 30 Jun 2009 23:00:00 +0100 2573665 http://www.medworm.com/index.php?rid=2573664&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572813%26dopt%3DAbstract Authors: Wilson B PMID: 19572813 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2573664 Tue, 30 Jun 2009 23:00:00 +0100 2573664 http://www.medworm.com/index.php?rid=2573663&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572814%26dopt%3DAbstract News & Views in ... Nanomedicine. Nanomed. 2009 Jul;4(5):503-505 Authors: PMID: 19572814 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2573663 Tue, 30 Jun 2009 23:00:00 +0100 2573663 http://www.medworm.com/index.php?rid=2573662&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572815%26dopt%3DAbstract Authors: Chan WC PMID: 19572815 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2573662 Tue, 30 Jun 2009 23:00:00 +0100 2573662 http://www.medworm.com/index.php?rid=2573661&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572816%26dopt%3DAbstract Authors: Sharma HS, Sharma A The 6th GCNN Annual meeting was held in the Hilton Hotel, Vienna, Austria, on 1-4 March, 2009. In this conference a special focus was given to 'Nanomedicine: Nanoneuropharmacology and Nanoneurotoxicity' on 2-3 March, 2009. The 'Nanomedicine Focus' was organized by M Robertson (London, UK) and H Shanker Sharma (Uppsala, Sweden) and was divided into three sessions on 2 March, followed by one session on 3 March. In total, 11 speakers participated in these sessions covering more than 5 h of intensive presentations intermingled with lively discussions from the audience. PMID: 19572816 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2573661 Tue, 30 Jun 2009 23:00:00 +0100 2573661 http://www.medworm.com/index.php?rid=2573660&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572817%26dopt%3DAbstract Authors: Beck D, Wong ST The IEEE-NIH 4th Life Science Systems and Applications Workshop 2009 (LiSSA '09) was jointly organized by the IEEE LiSSA Technical Committee and the NIH Nano Task Force. It was endorsed by the NIH Biomedical Information Science and Technology Initiative (BISTI) and the National Library of Medicine. The workshop was held in the Natcher Conference Center on the NIH campus in Bethesda, MD, USA. It took place on the 9-10 April, 2009, during the NIH NanoWeek and had approximately 200 delegates from around the globe (including North America, Europe, Asia and Australia) from both engineering and biomedical science disciplines. The conference featured around 40 talks, including nine plenary speakers emphasizing current state-of-the-art nanotechnology practices, develop... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2573660 Tue, 30 Jun 2009 23:00:00 +0100 2573660 http://www.medworm.com/index.php?rid=2573659&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572818%26dopt%3DAbstract Authors: Misra R, Acharya S, Dilnawaz F, Sahoo SK Aim: To increase the entrapment efficiency of doxycycline (DXY)-loaded poly(D,L-lactide-co-glycolide) (PLGA):poly(epsilon-caprolactone) (PCL) nanoparticles by up to 70% by varying the different formulation parameters such as polymer ratio, amount of drug loading (w/w), solvent selection, electrolyte addition and pH in the formulation. Method: Biodegradable polymers PLGA and PCL are used in various ratios for nanoparticle preparation using the water-in-oil-in-water double emulsion technique for water-soluble DXY. The physicochemical characterization of nanoparticles included size and surface charge measurement, study of surface morphology using scanning-electron microscopy, Fourier transform infrared spectroscopy study, differential scan... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2573659 Tue, 30 Jun 2009 23:00:00 +0100 2573659 http://www.medworm.com/index.php?rid=2573658&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572819%26dopt%3DAbstract Conclusion: These results show a low toxicity of BP both in vitro and in vivo. PMID: 19572819 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2573658 Tue, 30 Jun 2009 23:00:00 +0100 2573658 http://www.medworm.com/index.php?rid=2573657&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572820%26dopt%3DAbstract This article focuses on the pathobiology of common neurodegenerative disorders with a view towards how nanomedicine may be used to improve the clinical course of neurodegenerative disorders. PMID: 19572820 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2573657 Tue, 30 Jun 2009 23:00:00 +0100 2573657 http://www.medworm.com/index.php?rid=2573656&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572821%26dopt%3DAbstract This article focuses on how nanotechnology can serve to improve the delivery of antiretroviral medicines, termed nanoART, across the BBB and affect the biodistribution and clinical benefit for HIV-1 disease. PMID: 19572821 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2573656 Tue, 30 Jun 2009 23:00:00 +0100 2573656 http://www.medworm.com/index.php?rid=2573655&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572822%26dopt%3DAbstract This article discusses plant virus nanoparticles as a weapon in the war on cancer. The successes and failures of numerous nanoparticle strategies are discussed as a background to consideration of the plant virus nanoparticle approach. To have therapeutic benefit, the advantages of the targeted nanoparticle must outweigh the problems of colloidal stability, uptake by the reticuloendothelial system as well as the requirement for clearance from the body. Biodegradable nanoparticles are considered to have the most promise to address these complex phenomena. After justifying the choice of biodegradable particles, the article focuses on comparison of micelles, liposomes, polymers and modified plant viruses. The structural uniformity, cargo capacity, responsive behavior and ease of manufacturing ... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2573655 Tue, 30 Jun 2009 23:00:00 +0100 2573655 http://www.medworm.com/index.php?rid=2573654&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19572823%26dopt%3DAbstract Authors: PMID: 19572823 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2573654 Tue, 30 Jun 2009 23:00:00 +0100 2573654 http://www.medworm.com/index.php?rid=2528073&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19505237%26dopt%3DAbstract Authors: Halas NJ PMID: 19505237 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2528073 Sun, 31 May 2009 23:00:00 +0100 2528073 http://www.medworm.com/index.php?rid=2528072&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19505238%26dopt%3DAbstract Authors: Simeonova PP PMID: 19505238 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2528072 Sun, 31 May 2009 23:00:00 +0100 2528072 http://www.medworm.com/index.php?rid=2528071&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19505241%26dopt%3DAbstract Authors: Singh N The conference on Nanotoxicology: Health & Environmental Impacts was organized by Euroscicon (Welwyn Garden City, UK), a team of professionals working towards the continuous improvement of technical knowledge transfer for all scientists, and hosted by 'BioPark', a research and development center in Welwyn Garden City, UK, on the 27th February 2009. The 1-day conference was chaired by SH Doak, Senior Lecturer and Research Councils UK Academic Fellow in Nanomedicine at Swansea University (Wales, UK) and brought together eminent scientists from seven different countries to interact and discuss the latest developments in the rapidly proliferating field of nanotechnology. PMID: 19505241 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2528071 Sun, 31 May 2009 23:00:00 +0100 2528071 http://www.medworm.com/index.php?rid=2528070&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19505242%26dopt%3DAbstract This study demonstrates that a combination of unconventional electron microscopy techniques provides a quantitative means of assessing the degree of monodispersity of gadolinium (Gd) diethylenetriamine pentaacetic acid-conjugated polyamidoamine (PAMAM) dendrimers, which are designed for diagnostic imaging and delivering chemotherapeutics. Specifically, analysis of images acquired in the scanning transmission electron microscopy mode yields the distribution of molecular weights of individual dendrimers, whereas analysis of images acquired in the energy-filtering transmission electron microscopy mode yields the distribution of Gd atoms bound to the dendrimer nanoparticles. Measured compositions of Gd-conjugated G7 and G8 PAMAM dendrimers were consistent with the known synthetic chemistry. Th... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2528070 Sun, 31 May 2009 23:00:00 +0100 2528070 http://www.medworm.com/index.php?rid=2528069&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19505243%26dopt%3DAbstract CONCLUSION: These data suggest that CYT-6091 delivers TNF-alpha preferentially to the tumor and that upon TNF-alpha degradation, the liver takes up Au, which is cleared slowly over time. PMID: 19505243 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2528069 Sun, 31 May 2009 23:00:00 +0100 2528069 http://www.medworm.com/index.php?rid=2528068&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19505244%26dopt%3DAbstract CONCLUSION: This technique could enable better understanding of lymph node metastasis. PMID: 19505244 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2528068 Sun, 31 May 2009 23:00:00 +0100 2528068 http://www.medworm.com/index.php?rid=2528067&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19505245%26dopt%3DAbstract CONCLUSION: These results suggest that DAPHP and HA silver nanoparticles have potential in antimicrobial therapeutic applications. PMID: 19505245 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2528067 Sun, 31 May 2009 23:00:00 +0100 2528067 http://www.medworm.com/index.php?rid=2528063&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19505246%26dopt%3DAbstract CONCLUSION: Trastuzumab conjugated onto the NP surface has two functions: one is to target HER2-overexpressing cancer cells and the other is to enhance the cytotoxicity of docetaxel through synergistic effects. The trastuzumab-functionalized, docetaxel-loaded NPs have great potential for targeted chemotherapy to treat HER2-overexpressing cancer. PMID: 19505246 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2528063 Sun, 31 May 2009 23:00:00 +0100 2528063 http://www.medworm.com/index.php?rid=2528062&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19505247%26dopt%3DAbstract Authors: Bally M, Vörös J Technology for the detection of biological species has generated considerable interest in a variety of fields including healthcare, defense, food and environmental monitoring. In a biosensor, labeled specific binding partners are used to emit a detectable signal. Owing to their unique properties, nanomaterials have been proposed as a novel label category and have led to the development of new assays and new transduction mechanisms. In this article, the role of three major types of nanoscale labels (metallic, semiconductor and liposome nanoparticles) in the development of a new generation of optical, electrochemical or gravimetric biosensors will be presented. The underlying transduction principles will be briefly explained and assay strategies relyin... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2528062 Sun, 31 May 2009 23:00:00 +0100 2528062 http://www.medworm.com/index.php?rid=2528061&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19505248%26dopt%3DAbstract Authors: Tamburro AM The author describes, in a quite unconventional way, the most important results achieved in the last 50 years in the field of elastin structure-elasticity relationships, beginning with the first invaluable findings of Partridge on desmosines and isodesmosines until the most recent theories on elastomeric proteins. The author also relates a scientific autobiography characterized by his greatest passion, elastin. PMID: 19505248 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2528061 Sun, 31 May 2009 23:00:00 +0100 2528061 http://www.medworm.com/index.php?rid=2301927&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19331530%26dopt%3DAbstract CONCLUSION: Results support the use of these copolymers as gene delivery systems in the future. Finally, the use of microwaves makes the proposed synthetic method advantageous as time and solvents are saved. PMID: 19331530 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2301927 Sun, 01 Mar 2009 05:00:00 +0100 2301927 http://www.medworm.com/index.php?rid=2301923&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19331531%26dopt%3DAbstract Authors: Dalby MJ PMID: 19331531 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2301923 Sun, 01 Mar 2009 05:00:00 +0100 2301923 http://www.medworm.com/index.php?rid=2301920&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19331532%26dopt%3DAbstract Authors: Jain KK PMID: 19331532 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2301920 Sun, 01 Mar 2009 05:00:00 +0100 2301920 http://www.medworm.com/index.php?rid=2301917&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19331533%26dopt%3DAbstract Authors: Lapotko D PMID: 19331533 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2301917 Sun, 01 Mar 2009 05:00:00 +0100 2301917 http://www.medworm.com/index.php?rid=2301913&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19331536%26dopt%3DAbstract CONCLUSIONS: Gold nanorod-mediated photothermolysis provides one promising way to eliminate activated macrophages in autoimmune and inflammatory diseases. PMID: 19331536 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2301913 Sun, 01 Mar 2009 05:00:00 +0100 2301913 http://www.medworm.com/index.php?rid=2301910&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19331537%26dopt%3DAbstract CONCLUSION: Complex multicellular model systems, along with homogenous cell models, should be utilized in standard screening and monitoring procedures for evaluating nanomaterial safety. PMID: 19331537 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2301910 Sun, 01 Mar 2009 05:00:00 +0100 2301910 http://www.medworm.com/index.php?rid=2301907&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19331538%26dopt%3DAbstract CONCLUSION: The combined PS-electroporation method provides a fast and efficient protocol for ferumoxide-based cellular imaging and therapeutic procedure. PMID: 19331538 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2301907 Sun, 01 Mar 2009 05:00:00 +0100 2301907 http://www.medworm.com/index.php?rid=2301906&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19331539%26dopt%3DAbstract CONCLUSION: The feasibility of targeting magnetic carbon nanotubes to lymph nodes was demonstrated and the results support further studies for their potential use in diagnosing and treating cancer. PMID: 19331539 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2301906 Sun, 01 Mar 2009 05:00:00 +0100 2301906 http://www.medworm.com/index.php?rid=2301905&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19331540%26dopt%3DAbstract Authors: Buxton DB Nanotechnology provides a broad range of opportunities to develop new solutions for clinical problems. For the pulmonary field, nanotechnology promises better delivery of drugs and nucleic acid-based therapeutics to disease sites. Administration of therapeutics via inhalation provides the opportunity for direct delivery to the lung epithelium, the lining of the respiratory tract. By appropriate selection of particle size, deep lung delivery can be obtained with control of phagocytic uptake, the removal of particles by resident macrophages. Nanotechnology can also help in pulmonary therapies administered by intravenous and oral routes through targeting specific cell types and controlling bioavailability and release kinetics. In the hematology field, nanotechnology can... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2301905 Sun, 01 Mar 2009 05:00:00 +0100 2301905 http://www.medworm.com/index.php?rid=2301904&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19331541%26dopt%3DAbstract Authors: Tamaki Y Polyion complex (PIC) micelles have a size range of tens of nanometers formed through electrostatic interaction. In experimental choroidal neovascularization (CNV) in rats, the PIC micelle accumulates to the CNV lesions and is retained. PIC micelles can be used for effective drug delivery to CNV. A novel dendritic photosensitizer encapsulated by a polymeric-micelle formulation was employed for an effective photodynamic therapy for age-related macular degeneration. With its highly selective accumulation on experimental CNV lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity. Gene therapy is a promising approach to treat age-related macular degeneration. A ternary complex, composed of a core containing DNA pa... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2301904 Sun, 01 Mar 2009 05:00:00 +0100 2301904 http://www.medworm.com/index.php?rid=2301903&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19331542%26dopt%3DAbstract Authors: Yaghini E, Seifalian AM, MacRobert AJ Semiconductor quantum dots have received considerable interest in recent years as a result of their unique optical properties, leading to many applications in biology. This review examines their potential for photosensitization in photodynamic therapy compared with, and in combination with, conventional photosensitizing organic dyes. Photodynamic therapy is used for treating a range of malignant tumors and certain non-malignant pathologies, and conventional photosensitizers are based on organic dyes that are efficient generators of cytotoxic reactive oxygen species. By exploiting the unique optical properties of quantum dots, the conjugation of quantum dots with photosensitizers and targeting agents could provide a new class of versatile m... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2301903 Sun, 01 Mar 2009 05:00:00 +0100 2301903 http://www.medworm.com/index.php?rid=2168230&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19193181%26dopt%3DAbstract CONCLUSION: Rodent and CAM models led to the same conclusion regarding the benefits of nanoencapsulation to improve selective accumulation of drug in ovarian micrometastases. PMID: 19193181 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2168230 Sun, 01 Feb 2009 05:00:00 +0100 2168230 http://www.medworm.com/index.php?rid=2168229&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19193182%26dopt%3DAbstract CONCLUSIONS: It was determined that several of the commercial sunscreens contained distinct nanoparticles. No one method was able to completely characterize nanoparticles in the unmodified products but the viable methods provided complementary information regarding the nanoparticles and how they were interacting with the sunscreen matrix. PMID: 19193182 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2168229 Sun, 01 Feb 2009 05:00:00 +0100 2168229 http://www.medworm.com/index.php?rid=2168228&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19193183%26dopt%3DAbstract CONCLUSION: The prepared conjugate represents a novel biomaterial that is able to provide nanoparticles, which can be further loaded with drugs, such as anticancer agents, and addressed to osteolytic or other bone diseases. PMID: 19193183 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2168228 Sun, 01 Feb 2009 05:00:00 +0100 2168228 http://www.medworm.com/index.php?rid=2168227&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19193184%26dopt%3DAbstract Authors: Soenen SJ, Hodenius M, De Cuyper M The high biocompatibility and versatile nature of liposomes have made these particles keystone components in many hot-topic biomedical research areas. Liposomes can be combined with a large variety of nanomaterials, such as superparamagnetic iron oxide nanocores. Because the unique features of both the magnetizable colloid and the versatile lipid bilayer can be joined, the resulting so-called magnetoliposomes can be exploited in a great array of biotechnological and biomedical applications. In this article, we highlight the use of magnetoliposomes in immobilizing enzymes, both water-soluble and hydrophobic ones, as well as their potential in several biomedical applications, including MRI, hyperthermia cancer treatment and drug delivery. The g... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2168227 Sun, 01 Feb 2009 05:00:00 +0100 2168227 http://www.medworm.com/index.php?rid=2168226&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19193185%26dopt%3DAbstract Authors: Madurantakam PA, Cost CP, Simpson DG, Bowlin GL Native extracellular matrix (ECM) provides structural support to the multicellular organism on a macroscopic scale and establishes a unique microenvironment (niche) to tissue- and organ-specific cell types. Both these functions are critical for optimal function of the organism. These natural ECMs comprise predominantly fibrillar proteins, collagen and elastin and are synthesized as monomers but undergo hierarchical organization into well-defined nanoscaled structural units. The interaction between the cells and ECM is dynamic, reciprocal and essential for tissue development, maintenance of function, repair and regeneration processes. Tissue-engineering scaffolds are synthetic, biomimetic ECM analogues that have great promise in r... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2168226 Sun, 01 Feb 2009 05:00:00 +0100 2168226 http://www.medworm.com/index.php?rid=2168225&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19193186%26dopt%3DAbstract Authors: Xing Y, Dai L Recent studies on carbon nanomaterials for biological applications revealed that carbon nanodiamonds are much more biocompatible than most other carbon nanomaterials, including carbon blacks, fullerenes and carbon nanotubes. The noncytotoxic nature of nanodiamonds, together with their unique strong and stable photoluminescence, tiny size, large specific surface area and ease with which they can be functionalized with biomolecules, makes nanodiamonds attractive for various biomedical applications both in vitro and in vivo. In this article, we present some of the important issues concerning the synthesis and surface functionalization of diamond nanoparticles for nanomedicine as well as an overview of the recent progress in this exciting field by focusing on the pot... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2168225 Sun, 01 Feb 2009 05:00:00 +0100 2168225 http://www.medworm.com/index.php?rid=2168224&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19193187%26dopt%3DAbstract Authors: Maurer-Jones MA, Bantz KC, Love SA, Marquis BJ, Haynes CL A total of six nanotherapeutic formulations are already approved for medical use and more are in the approval pipeline currently. Despite the massive research effort in nanotherapeutic materials, there is relatively little information about the toxicity of these materials or the tools needed to assess this toxicity. Recently, the scientific community has begun to respond to the paucity of information by investing in the field of nanoparticle toxicology. This review is intended to provide an overview of the techniques needed to assess toxicity of these therapeutic nanoparticles and to summarize the current state of the field. We begin with background on the toxicological assessment techniques used currently as well as co... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2168224 Sun, 01 Feb 2009 05:00:00 +0100 2168224 http://www.medworm.com/index.php?rid=2075534&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19112621%26dopt%3DAbstract Subcellular targeting with cloaked quantum dots. Nanomed. 2009 Jan;4(1):7-8 Authors: Corbin I, Scott B, Zheng G PMID: 19112621 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2075534 Thu, 01 Jan 2009 05:00:00 +0100 2075534 http://www.medworm.com/index.php?rid=2075533&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19112622%26dopt%3DAbstract Authors: Corbin I, Scott B, Zheng G PMID: 19112622 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2075533 Thu, 01 Jan 2009 05:00:00 +0100 2075533 http://www.medworm.com/index.php?rid=2068027&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19108349%26dopt%3DAbstract A safer and more effective strategy for siRNA delivery. Nanomed. 2009 Jan;4(1):8-9 Authors: Corbin I, Scott B, Zheng G PMID: 19108349 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2068027 Sun, 28 Dec 2008 13:11:45 +0100 2068027 http://www.medworm.com/index.php?rid=2068026&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19108350%26dopt%3DAbstract Authors: Corbin I, Scott B, Zheng G PMID: 19108350 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2068026 Sun, 28 Dec 2008 13:11:41 +0100 2068026 http://www.medworm.com/index.php?rid=2053521&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19093890%26dopt%3DAbstract Authors: Martin CR PMID: 19093890 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2053521 Sat, 20 Dec 2008 14:09:21 +0100 2053521 http://www.medworm.com/index.php?rid=2053520&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19093891%26dopt%3DAbstract News & views in nanomedicine. Nanomed. 2009 Jan;4(1):3-5 Authors: PMID: 19093891 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2053520 Sat, 20 Dec 2008 14:09:18 +0100 2053520 http://www.medworm.com/index.php?rid=2053519&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19093892%26dopt%3DAbstract Authors: Corbin I, Scott B, Zheng G PMID: 19093892 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2053519 Sat, 20 Dec 2008 14:09:15 +0100 2053519 http://www.medworm.com/index.php?rid=2053518&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19093893%26dopt%3DAbstract Conclusion: The use of cell lines is of only limited predictive value when studying cell-substrate interactions but both morphology and alignment of human astrocytes were affected profoundly by nanofibers. Nanofiber surface functionalization with collagen significantly improved hNP-AC adhesion and migration. Alternative forms of functionalization may be required for optimal axon-nanofiber interactions. PMID: 19093893 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2053518 Sat, 20 Dec 2008 14:09:06 +0100 2053518 http://www.medworm.com/index.php?rid=2053517&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19093894%26dopt%3DAbstract Conclusions: We have reported herein that the fibrillogenesis of elastin-derived EX28 and EX30 polypeptides is facilitated significantly by the effect of sodium taurocholate bile salt and is inhibited by a classical inhibitor of Abeta-amyloid peptide, such as KLVFF, as well as by novel inhibitors, designed by us on the basis of some elastin sequences. PMID: 19093894 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2053517 Sat, 20 Dec 2008 14:09:02 +0100 2053517 http://www.medworm.com/index.php?rid=2053516&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19093895%26dopt%3DAbstract Authors: Vaijayanthimala V, Chang HC In recent years, carbon and carbon-based nanomaterials have received increasing attention for applications in life sciences. Nanodiamond (ND) stands out as a unique new substance in these applications because it holds several momentous properties such as good biocompatibility, excellent photostability and facile surface functionalizability. A number of experiments have shown that ND has the highest biocompatibility of all carbon-based nanomaterials including carbon blacks, multiwalled nanotubes, single-walled nanotubes and fullerenes. Additionally, the surface of ND can be readily derivatized with various functional groups for either covalent or noncovalent conjugation with biomolecules. Furthermore, some radiation-damaged NDs can emit strong and st... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2053516 Sat, 20 Dec 2008 14:08:58 +0100 2053516 http://www.medworm.com/index.php?rid=2053515&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19093896%26dopt%3DAbstract Authors: Kaiser JP, Krug HF, Wick P Nanoparticulate materials and, among them, carbon nanotubes (CNTs) are new types of material that are generating high expectations owing to their unique physical, chemical and optical properties. Owing to the predictably increasing production of various types of CNTs and other nanoparticle-containing products, it is expected that environmental and public exposure to engineered nanoparticles will also increase in parallel. If and how far CNTs are able to affect health is, at present, discussed controversially. In this article, we summarize how CNTs are produced and processed to identify critical parameters, which have to be included in the toxicological assessment. A special effort is made to address the adverse effects of CNTs on cell physiology. Fur... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2053515 Sat, 20 Dec 2008 14:08:51 +0100 2053515 http://www.medworm.com/index.php?rid=2053514&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19093897%26dopt%3DAbstract This article reviews the main strategies followed to achieve solutions to this challenge, particularly emphasizing the working hypothesis followed by the authors to elucidate the mechanisms behind the observed effects of structured surfaces on cell behavior. PMID: 19093897 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2053514 Sat, 20 Dec 2008 14:08:43 +0100 2053514 http://www.medworm.com/index.php?rid=2053513&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19093898%26dopt%3DAbstract Authors: Yezhelyev M, Yacoub R, O'Regan R Nanoparticles (NPs) and nanosized objects are being incorporated rapidly into clinical medicine and particularly into the field of medical oncology, including breast cancer. A number of novel methods for breast cancer diagnosis and treatment, which are based on NPs and other nanodevices, are now available for translation into clinical practice. Computer tomography and MRI with iron-based magnetic NPs are promising methods for radiological detection of cancers. Semiconductor fluorescent NPs (quantum dots) are being developed for simultaneous detection and localization of multiple breast cancer biomarkers, enabling the personalization of therapeutic regimens for each patient. Additionally, inorganic NPs can be conjugated with tumor-specific ligan... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2053513 Sat, 20 Dec 2008 14:08:38 +0100 2053513 http://www.medworm.com/index.php?rid=2053512&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19093899%26dopt%3DAbstract Authors: Muthu MS, Singh S Novel technology in the nanomedicine field is expected to develop innovative products as targeted drug-delivery approaches. Targeted drug delivery of various drugs for the treatment of cancer, AIDS and brain disorders is the primary research area in which nanomedicines have a major role and need. This review is concerned with emerging targeted nanomedicines (polymeric nanoparticles, solid lipid nanoparticles, polymeric micelles, dendrimers, liposomes, gold nanoparticles and magnetic nanoparticles) and multifunctional carriers capable of combining targeted drug delivery and imaging (polymeric micelles, dendrimers and magnetic nanoparticles) in the field of pharmaceutical applications. The significant toxicity issues associated with these nanomedicines are also... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2053512 Sat, 20 Dec 2008 14:08:33 +0100 2053512 http://www.medworm.com/index.php?rid=2053511&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19093900%26dopt%3DAbstract Authors: PMID: 19093900 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=2053511 Sat, 20 Dec 2008 14:08:29 +0100 2053511 http://www.medworm.com/index.php?rid=1992017&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19025448%26dopt%3DAbstract Authors: Alexander C PMID: 19025448 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1992017 Thu, 27 Nov 2008 13:43:48 +0100 1992017 http://www.medworm.com/index.php?rid=1992016&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19025449%26dopt%3DAbstract News & views in nanomedicine. Nanomed. 2008 Dec;3(6):753-5 Authors: PMID: 19025449 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1992016 Thu, 27 Nov 2008 13:43:45 +0100 1992016 http://www.medworm.com/index.php?rid=1992015&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19025450%26dopt%3DAbstract Authors: Kim JS PMID: 19025450 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1992015 Thu, 27 Nov 2008 13:43:42 +0100 1992015 http://www.medworm.com/index.php?rid=1992014&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19025451%26dopt%3DAbstract Conclusion: We demonstrate NDS-enhanced efficiency of chemotherapy to a level that cannot be achieved by applying its components separately. PMID: 19025451 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1992014 Thu, 27 Nov 2008 13:43:39 +0100 1992014 http://www.medworm.com/index.php?rid=1992013&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19025452%26dopt%3DAbstract Conclusions: 5-ALA-conjugated nanoparticles offer a new modality for selective and efficient destruction of tumor cells, with minimal damage to fibroblasts in the 5-ALA-photodynamic therapy. PMID: 19025452 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1992013 Thu, 27 Nov 2008 13:43:35 +0100 1992013 http://www.medworm.com/index.php?rid=1992012&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19025453%26dopt%3DAbstract Conclusions: Attachment of ethanolamine to the carboxylate groups on the pore wall lowered the anionic charge density on the wall. This mitigated the problem of electrostatic rejection of the anionic DNAs from the pore and enabled the detection of these DNA analytes. PMID: 19025453 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1992012 Thu, 27 Nov 2008 13:43:31 +0100 1992012 http://www.medworm.com/index.php?rid=1992011&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19025454%26dopt%3DAbstract Conclusions: Photothermal bubbles generated around laser-activated gold NPs may significantly improve the sensitivity and specificity of cell imaging, and can be considered as a new type of optical cellular probes. PMID: 19025454 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1992011 Thu, 27 Nov 2008 13:43:28 +0100 1992011 http://www.medworm.com/index.php?rid=1992010&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19025455%26dopt%3DAbstract Conclusion: PEG-PBLG nanoparticles may be a superior gene carrier in future clinical applications because of their DNA protection and higher gene-transfer efficiency. The HSV-TK/GCV suicide-gene system had significant antitumor effects on OSCC. PMID: 19025455 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1992010 Thu, 27 Nov 2008 13:43:24 +0100 1992010 http://www.medworm.com/index.php?rid=1992009&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19025456%26dopt%3DAbstract Authors: Pancrazio JJ Bioelectrical neural interfaces provide a means of recording the activity from the nervous system and delivering therapeutic stimulation to restore neurological function lost during disease or injury. Although neural interfaces have reached clinical utility, reducing the size of the bioelectrical interface to minimize damage to neural tissue and maximize selectivity has proven problematic. Nanotechnology may offer a means of interfacing with the nervous system with unprecedented specificity. Emergent applications of nanotechnology to neuroscience include molecular imaging, drug delivery across the BBB, scaffolds for neural regeneration and bioelectrical interfaces. In particular, carbon nanotubes offer the promises of material stability and low electrical impedanc... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1992009 Thu, 27 Nov 2008 13:43:21 +0100 1992009 http://www.medworm.com/index.php?rid=1992008&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19025457%26dopt%3DAbstract Authors: Gazeau F, Lévy M, Wilhelm C Current developments in nanotechnology offer new tools to the design of nanometric heat-generating 'foci' that can be activated remotely by an external alternating magnetic field. These nanometric heat sources may serve for therapeutic hyperthermia alone or combined with other therapeutic modalities, such as drug delivery or gene therapy. Activable therapeutic tools at the nanoscale fulfill the requirements of future medicine in terms of spatial targeting and temporal control of therapy. The present review discusses fundamental aspects regarding the design of magnetic nanoparticles with optimized properties, by unraveling physical mechanisms that govern heating power in biological media. Towards therapy, achievements and promises of magnetic na... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1992008 Thu, 27 Nov 2008 13:43:18 +0100 1992008 http://www.medworm.com/index.php?rid=1992007&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19025458%26dopt%3DAbstract Authors: de la Fuente M, Csaba N, Garcia-Fuentes M, Alonso MJ One of the most exciting and challenging applications of nanotechnology in medicine is the development of nanocarriers for the intraepithelial delivery of biomacromolecules through mucosal surfaces. These biomacromolecules represent an increasingly important segment of the therapeutic arsenal; however, their potential is still limited by their instability and inability to cross biological barriers. Nanoparticle carriers have emerged as one of the most promising technologies to overcome this limitation, owing mainly to their demonstrated capacity to interact with biological barriers. In this review, we summarize the current advances made on nanoparticles designed for transmucosal delivery. Supported by the examples of a varie... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1992007 Thu, 27 Nov 2008 13:43:15 +0100 1992007 http://www.medworm.com/index.php?rid=1992006&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19025459%26dopt%3DAbstract Authors: Faunce TA, White J, Matthaei KI Much contemporary nanotoxicology, nanotherapeutic and nanoregulatory research has been characterized by a focus on investigating how delivery of engineered nanoparticles (ENPs) to cells is dictated primarily by components of the ENP surface. An alternative model, some implications of which are discussed here, begins with fundamental physicochemical research into the interaction of a dynamic nanoparticle-protein corona (NPC) with biological systems. The proposed new model also requires, however, that any such fresh NPC physicochemical research approach should involve integration and targeted collaboration from the earliest stages with nanotoxicology, nanotherapeutics and nanoregulatory expertise. The justification for this integrated approach, we... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1992006 Thu, 27 Nov 2008 13:43:11 +0100 1992006 http://www.medworm.com/index.php?rid=1992005&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19025460%26dopt%3DAbstract Authors: PMID: 19025460 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1992005 Thu, 27 Nov 2008 13:43:08 +0100 1992005 http://www.medworm.com/index.php?rid=1856638&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18834270%26dopt%3DAbstract CONCLUSIONS: Contrary to what is found for bare silver nanoparticles, Ag@tiopronin nanoparticles are noncytotoxic to macrophages. Ag@tiopronin nanoparticles showed differential effects on TLR signaling of a high degree of specificity, without proinflammatory effects by themselves. These effects have to be borne in mind when using bioconjugates of Ag@tiopronin nanoparticles for future medical applications. PMID: 18834270 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1856638 Wed, 01 Oct 2008 04:00:00 +0100 1856638 http://www.medworm.com/index.php?rid=1833619&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18817462%26dopt%3DAbstract Authors: Jahnen-Dechent W, Simon U PMID: 18817462 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1833619 Sat, 27 Sep 2008 15:17:26 +0100 1833619 http://www.medworm.com/index.php?rid=1833618&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18817463%26dopt%3DAbstract Authors: Baun A, Hansen SF PMID: 18817463 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1833618 Sat, 27 Sep 2008 15:17:24 +0100 1833618 http://www.medworm.com/index.php?rid=1833617&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18817464%26dopt%3DAbstract Authors: PMID: 18817464 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1833617 Sat, 27 Sep 2008 15:17:21 +0100 1833617 http://www.medworm.com/index.php?rid=1833616&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18817465%26dopt%3DAbstract Authors: Venkatesan BM, Elibol O, Dorvel B, Park K, Bashir R PMID: 18817465 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1833616 Sat, 27 Sep 2008 15:17:18 +0100 1833616 http://www.medworm.com/index.php?rid=1833615&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18817466%26dopt%3DAbstract CONCLUSION: This work demonstrated potential applications of gold nanospheres as both imaging probes and enhancing agents for photothermal therapy of cancer. PMID: 18817466 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1833615 Sat, 27 Sep 2008 15:17:12 +0100 1833615 http://www.medworm.com/index.php?rid=1833614&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18817467%26dopt%3DAbstract CONCLUSIONS: The antioxidant efficacy of CeO(2) nanoparticles can be enhanced by dissolving zirconium in the CeO(2) lattice. The Ce(x)Zr(1-x)O(2) nanoparticles act as an enhanced catalyst at room temperature that scavenges ROS. Increased efficacy will enable lower nanoparticle dosages to protect cells from ROS, thus increasing the therapeutic width of these compounds. PMID: 18817467 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1833614 Sat, 27 Sep 2008 15:17:07 +0100 1833614 http://www.medworm.com/index.php?rid=1833613&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18817468%26dopt%3DAbstract Authors: Hleb EY, Hafner JH, Myers JN, Hanna EY, Rostro BC, Zhdanok SA, Lapotko DO BACKGROUND: We have developed a method, termed laser-activated nano-thermolysis as a cell elimination technology (LANTCET), for the selective detection and destruction of individual tumor cells by the generation of intracellular photothermal bubbles around clusters of gold nanoparticles. METHOD: Bare nanoparticles and their conjugates to C225 tumor-specific monoclonal antibodies were applied in vitro to C225-positive squamous carcinoma cells and in vivo to an experimental tumor in a rat in order to form intracellular clusters of nanoparticles. RESULTS: Single 10 ns laser pulses generated intracellular photothermal microbubbles at a near-infrared and visible wavelengths. The cells with the clusters yielde... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1833613 Sat, 27 Sep 2008 15:17:02 +0100 1833613 http://www.medworm.com/index.php?rid=1833612&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18817469%26dopt%3DAbstract Authors: Zhu S, Li F, Du C, Fu Y A new silver (Ag) nanostructure with a rectangular distribution array composed of rhombic nanoparticles is described here. The structure has an apparent advantage of strong hot spots that have a much higher signal intensity than that of the previously reported traditional triangular structures. It generates a great enhancement of a localized surface plasmon resonance (LSPR) effect. Moreover, an antigen with longer arm length is applied to strengthen the binding signals of both the antigen and antibody. We performed experiments for the LSPR-induced extinction spectra in each step of the surface modification of the Ag nanoparticles in atmosphere environment. A spectrophotometer was used to measure the extinction spectrum of our proposed nanochip. The resu... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1833612 Sat, 27 Sep 2008 15:16:52 +0100 1833612 http://www.medworm.com/index.php?rid=1833611&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18817470%26dopt%3DAbstract Authors: Svenson S, Chauhan AS Approximately 40% of newly developed drugs are rejected by the pharmaceutical industry and will never benefit a patient because of low water solubility. Another 17% of launched drugs exhibit suboptimal performance for the same reason. Given the growing impact and need for drug delivery, a thorough understanding of delivery technologies that enhance the bioavailability of drugs is important. The high level of control over the dendritic architecture (size, branching density, surface functionality) makes dendrimers ideal excipients for enhanced solubility of poorly water-soluble drugs. Many commercial small-molecule drugs with anticancer, anti-inflammatory and antimicrobial activity have been formulated successfully with dendrimers, such as poly(amidoamine) ... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1833611 Sat, 27 Sep 2008 15:16:48 +0100 1833611 http://www.medworm.com/index.php?rid=1833610&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18817471%26dopt%3DAbstract This article presents a thorough discussion of the physiologic aspects of nanoparticle clearance, focusing on renal mechanisms, and provides an overview of current research investigating clearance of specific types of nanoparticles and nano-sized macromolecules, including dendrimers, quantum dots, liposomes and carbon, gold and silica-based nanoparticles. PMID: 18817471 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1833610 Sat, 27 Sep 2008 15:16:44 +0100 1833610 http://www.medworm.com/index.php?rid=1833609&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18817472%26dopt%3DAbstract Authors: Rakesh L, Howell BA, Chai M, Mueller A, Kujawski M, Fan D, Ravi S, Slominski C Nanotechnology has the potential to impact the treatment of many diseases that currently plague society: cancer, AIDS, dementia of various kinds and so on. Nanoscale smart materials, such as carbon nanotubes, C(60), dendrimers and cyclodextrins, hold great promise for use in the development of better diagnostics, drug delivery and the alteration of biological function. Although experimentation is being used to explore the potential offered by these materials, it is by its very nature expensive in terms of time, resources and expertise. Insight with respect to the behavior of these materials in the presence of biological entities can be obtained much more rapidly by molecular dynamics simulation. Fur... Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1833609 Sat, 27 Sep 2008 15:16:40 +0100 1833609 http://www.medworm.com/index.php?rid=1833608&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18817473%26dopt%3DAbstract Authors: PMID: 18817473 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1833608 Sat, 27 Sep 2008 15:16:38 +0100 1833608 http://www.medworm.com/index.php?rid=1701689&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694301%26dopt%3DAbstract Authors: Youan BB PMID: 18694301 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1701689 Fri, 01 Aug 2008 04:00:00 +0100 1701689 http://www.medworm.com/index.php?rid=1701688&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694302%26dopt%3DAbstract News & views in Nanomedicine. Nanomed. 2008 Aug;3(4):407-9 Authors: PMID: 18694302 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1701688 Fri, 01 Aug 2008 04:00:00 +0100 1701688 http://www.medworm.com/index.php?rid=1701687&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694303%26dopt%3DAbstract Authors: Dalby MJ, McNamara LE, Riehle MO, Burchmore R, Kuntanawat P, McMurray RJ, Gadegaard N, Andar A PMID: 18694303 [PubMed - as supplied by publisher] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1701687 Fri, 01 Aug 2008 04:00:00 +0100 1701687 http://www.medworm.com/index.php?rid=1701686&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694304%26dopt%3DAbstract Authors: Saatchi K, Häfeli UO PMID: 18694304 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1701686 Fri, 01 Aug 2008 04:00:00 +0100 1701686 http://www.medworm.com/index.php?rid=1701685&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694305%26dopt%3DAbstract CONCLUSIONS: The performance parameters of the nanomonitors, such as speed of detection on the order of minutes, volume of reagents of a few microliters and low cost per assay are comparable to traditional assay methods, such as ELISA. In addition, nanomonitors also provide the advantages of being a label-free technique with large linear dynamic range of detection and a significant reduction in the size of assay, thus making it an ideal candidate for a clinical diagnostic 'lab-on-a-chip' device for protein biomarker profiling and hence early disease diagnosis. PMID: 18694305 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1701685 Fri, 01 Aug 2008 04:00:00 +0100 1701685 http://www.medworm.com/index.php?rid=1701684&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694306%26dopt%3DAbstract CONCLUSION: The work describes the application of AF4/DLS/multiangle laser light scattering as a highly useful method for characterization of SPIO particles, enabling valuable information to be accessed in addition to that obtained by transmission-electron microscopy and DLS in batch mode. PMID: 18694306 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1701684 Fri, 01 Aug 2008 04:00:00 +0100 1701684 http://www.medworm.com/index.php?rid=1701683&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694307%26dopt%3DAbstract CONCLUSIONS: These results suggest that water-dispersed oxSWNHs may thus be useful as a drug carrier for local chemotherapy. PMID: 18694307 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1701683 Fri, 01 Aug 2008 04:00:00 +0100 1701683 http://www.medworm.com/index.php?rid=1701682&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694308%26dopt%3DAbstract Authors: Cao YC PMID: 18694308 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1701682 Fri, 01 Aug 2008 04:00:00 +0100 1701682 http://www.medworm.com/index.php?rid=1701681&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694309%26dopt%3DAbstract News & views in nanomedicine. Nanomed. 2008 Aug;3(4):471-3 Authors: PMID: 18694309 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1701681 Fri, 01 Aug 2008 04:00:00 +0100 1701681 http://www.medworm.com/index.php?rid=1701680&cid=s_36779_174_f&fid=36779&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D18694310%26dopt%3DAbstract CONCLUSION: This study demonstrates that binding activity of scFv/Qdot conjugates can be improved through structure-based genetic engineering of the scFv. PMID: 18694310 [PubMed - in process] (Source: Nanomedicine) Nanomedicine journals http://www.medworm.com/rss/comments.php?id=1701680 Fri, 01 Aug 2008 04:00:00 +0100 1701680