MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Natural Product Research' source. Thu, 09 Feb 2012 13:38:42 +0100 http://www.medworm.com/index.php?rid=5656377&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22288518%26dopt%3DAbstract Authors: Santos RF, Martins IR, Monteiro FD, Travassos RD, Janebro DI, Tavares JF, Silva MS, da Silva BA Abstract We aimed to investigate the possible spasmolytic activity of ent-7α-acetoxytrachyloban-18-oic acid (1) and ent-7α-hydroxytrachyloban-18-oic acid (2) on smooth muscle models. In male rat aorta and rat uterus, both diterpenes were unable to trigger spasmolytic action. However, 2 relaxed guinea-pig trachea: Compounds 1 and 2 antagonised, significantly and concentration-dependently, carbachol- and histamine-induced phasic contractions in guinea-pig ileum. Moreover, they induced a significant and concentration-dependent relaxation in pre-contracted (KCl, carbachol or histamine) guinea-pig ileum, with 2 being 15 times more potent than 1 in histamine-contracted ileum. These ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5656377 Tue, 31 Jan 2012 05:00:00 +0100 5656377 http://www.medworm.com/index.php?rid=5656376&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22288562%26dopt%3DAbstract This study evaluated the anti-nociceptive and anti-inflammatory effects of triterpenoid-enriched extract of T. dioica root (CETD) in rodents at the doses of 50 and 100 mg kg(-1) body weight po. Anti-nociceptive activity was evaluated by acetic acid-induced writhing and tail flick methods in Swiss albino mice. CETD was evaluated for anti-inflammatory activity in experimental acute (carrageenan-, histamine- and serotonin-induced paw oedema) and chronic models (cotton pellet-induced granuloma) in Wistar albino rats. In writhing test, CETD dose dependently and significantly inhibited writhes; in tail flick test, CETD demonstrated significant increase in reaction time (after 60 and 120 min). In all the anti-inflammatory models, CETD exhibited promising anti-inflammatory activity in a dose... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5656376 Tue, 31 Jan 2012 05:00:00 +0100 5656376 http://www.medworm.com/index.php?rid=5656375&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22288603%26dopt%3DAbstract Authors: Piyasena KG, Dharmaratne HR Abstract Preliminary investigation of a number of plant extracts for allelopathic activity using seed germination inhibition bioassay showed a promising activity of the water extract of the aerial parts of Mikania scandens. Activity-guided fractionation of the M. scandens extract led to the isolation of the highly allelopathic active compound mikanolide, with minimum inhibitory concentration of 0.083 µM mL(-1). As M. scandens is a highly abundant invasive plant in Sri Lanka and other South Asian countries, this plant could be developed as an environment friendly natural herbicide, either in crude form as shredded plant material or as pure mikanolide, which is the major constituent (∼0.02%) in the plant. PMID: 22288603 [PubMed - as sup... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5656375 Tue, 31 Jan 2012 05:00:00 +0100 5656375 http://www.medworm.com/index.php?rid=5656374&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22292423%26dopt%3DAbstract This study was undertaken to evaluate the anti-angiogenic effect of M. citrifolia fruits and leaves. Anti-angiogenic activity was evaluated in vivo using the chick chorioallantoic membrane assay. Bioactivity-guided fractionation and isolation were performed to identify the active constituent, and high-performance liquid chromatography analysis was then used to quantify the amount of this active constituent in the active extracts and fraction. The methanol extracts of fruits and leaves of M. citrifolia and the subsequent chloroform fraction of the fruit methanolic extract were found to have potential anti-angiogenic activity and were more potent compared to suramin. Scopoletin was identified as one of the chemical constituents that may be partly responsible for the anti-angiogenic activity... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5656374 Tue, 31 Jan 2012 05:00:00 +0100 5656374 http://www.medworm.com/index.php?rid=5656373&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22292784%26dopt%3DAbstract Authors: Silva AA, Haraguchi SK, Cellet TS, Schuquel IT, Sarragiotto MH, Vidotti GJ, de Melo JO, Bersani-Amado CA, Zanoli K, Nakamura CV Abstract A phytochemical study of the ethyl acetate fractions from the partition of seeds and roots methanol extracts of Cenchrus echinatus L. led to the isolation of three resveratrol-derived stilbenoids: pallidol (1), carasiphenol C (2) and nepalensinol B (3). The results of a topic anti-inflammatory evaluation, DPPH assay and antiproliferative activity against adenocarcinoma cells (Caco 2) are described. PMID: 22292784 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5656373 Tue, 31 Jan 2012 05:00:00 +0100 5656373 http://www.medworm.com/index.php?rid=5656372&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22292837%26dopt%3DAbstract Authors: Congai Z, Yanyan G, Xuechang Z, Jing M, Wangpeng S Abstract The methodology of a new OA(9) (3(4)) matrix and an analysis of variance technique were developed during the optimisation of extracting pesticidal alkaloids from Cynanchum komarovii. Many factors were found to affect the amount of alkaloids extracted: which parts of the plant were used - roots gave the highest yield; particle size of the material - highest yield when the plant was sieved through size 40 mesh; the type of solvent - a mixture of 0.1% hydrochloric acid with industrial alcohol was the best; The ratio of material to solvent - 1 part plant material to eight parts solvent gave the highest extraction; the duration of the extraction - 72 h and the number of re-extractions - three also improved yield. T... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5656372 Tue, 31 Jan 2012 05:00:00 +0100 5656372 http://www.medworm.com/index.php?rid=5656371&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22292885%26dopt%3DAbstract Authors: Ravikumar S, Raja M, Gnanadesigan M Abstract The antibacterial activities of column chromatography fractions of n-hexane, benzene, chloroform, acetone, ethanol and water extracts from Acanthus ilicifolius were tested against 24 bacterial pathogens. The antibacterial activity was performed using agar diffusion method. Most active fractions were further investigated through UV-Vis, (13)C, (1)H-NMR, FT-IR for the structural elucidation. The antibacterial activity of the extracts was identified as 6-hydroxy-benzoxazolinone, (Z)-4-coumaric acid 4-O-β-D-glucopyranoside and 3,5-dimethoxy-4-hydroxy methyl benzoate. PMID: 22292885 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5656371 Tue, 31 Jan 2012 05:00:00 +0100 5656371 http://www.medworm.com/index.php?rid=5656370&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22292909%26dopt%3DAbstract In conclusion, we confirmed the inflammatory activity of MAP and affirm that this effect involves the reduction of TNF-α level. PMID: 22292909 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5656370 Tue, 31 Jan 2012 05:00:00 +0100 5656370 http://www.medworm.com/index.php?rid=5656369&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22292934%26dopt%3DAbstract In this study, we investigated the compound that can be used for the suppression of lipopolysacchaide (LPS) stimulated inflammatory responses in macrophages among the five isolated compounds. β-sitosterol-β-D-glucoside (1) was found to reduce nitric oxide (NO) production from LPS-induced RAW 264.7 cells the most. In addition, compound 1 strongly inhibited the interleukin 6 (IL-6) activities of stimulated macrophages. Treatment of RAW 264.7 cells with compound 1 reduced secretion of inflammatory elements including tumour necrosis factor - alpha (TNF-α) and interleukin 1 beta (IL-1β). Thus, compound 1 may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO. PMID: 22292934 [PubMed - as supplied by publish... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5656369 Tue, 31 Jan 2012 05:00:00 +0100 5656369 http://www.medworm.com/index.php?rid=5637058&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22273392%26dopt%3DAbstract Authors: Begum S, Naqvi SQ, Ahmed A, Tauseef S, Siddiqui BS Abstract In view of the attributed medicinal properties of reserpine, a number of acyl reserpine derivatives were prepared and tested for antimycobacterial activity against Mycobacterium tuberculosis, strain H(37)Rv and antioxidant activities. The results indicated that in the case of antimycobacterial activity, 10 out of 18 derivatives caused more inhibition than that caused by reserpine itself. The results of antioxidant activity revealed that acylation in benzene ring of reserpine decreases the percentage inhibition of DPPH in all the derivatives compared to the parent compound (1). PMID: 22273392 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5637058 Wed, 25 Jan 2012 05:00:00 +0100 5637058 http://www.medworm.com/index.php?rid=5637059&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22273350%26dopt%3DAbstract Authors: Boligon AA, Schwanz TG, Piana M, Bandeira RV, Frohlich JK, Brum TF, Zadra M, Athayde ML Abstract The essential oils obtained by hydrodistillation from the leaves of Tabernaemontana catharinensis had their composition analysed by GC-MS. A total of 18 substances were identified, consisting of a complex mixture of sesquiterpenes (83.52%), monoterpenes (5.46%) and triterpenes (4.56%). The main components in the oil were β-caryophyllene (56.87%), α-cadinol (12.52%), 8S,13-cedran-diol (5.41%), α-terpineol (3.99%), β-eudesmol (2.54%), caryophyllene oxide (2.51%) and ethyl iso-allocholate (2.03%) along with β-cubebene, γ-cadinene, cubenol, 1,8-cineol, o-cymene, curcumenol, spathulenol, friedeline and β-sitosterol as minor constituents. An antioxidant property was tested wit... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5637059 Tue, 24 Jan 2012 05:00:00 +0100 5637059 http://www.medworm.com/index.php?rid=5637060&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22263904%26dopt%3DAbstract Authors: Li P, Deng YP, Wei XX, Xu JH Abstract From the ethyl acetate fraction of the fruiting body of Ganoderma lucidum, a new triterpenoid, ethyl 7β-hydroxy-4,4,14α-trimethyl-3,11,15-trioxo-5α-chol-8-en-24-oate (4), named ethyl lucidenates A, along with three known compounds, ganodermanondiol (1), lucidumol B (2) and methyl lucidenates A (3) were isolated by silica gel column, ODS column chromatography and PHPLC. Their structures were established on the basis of spectroscopic analysis and chemical evidence. The isolated compounds were tested using in vitro MTT assay for their cytotoxic activities against the K562, HL-60, CA46, HepG2, SW480 and SMMC-7221 cancer cell lines. Among them, compound 4 showed cytotoxicity against HL-60 and CA46 cancer cell lines with IC(50) values of... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5637060 Fri, 20 Jan 2012 05:00:00 +0100 5637060 http://www.medworm.com/index.php?rid=5619220&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22260198%26dopt%3DAbstract Authors: Lappe R, Sant'anna V, Brandelli A Abstract Cerein 8A is an antimicrobial peptide with potential application against food spoilage and pathogenic bacteria. The partitioning of cerein 8A was investigated in two liquid-liquid extraction systems that are considered promising for bioseparation and purification purposes. Aqueous two-phase systems (ATPSs) were prepared with polyethylene glycol (PEG) and inorganic salts, and the addition of NaCl was investigated in this system. The best results concerning partition coefficients (K (b)) were obtained with PEG + ammonium sulphate, and K (b) value significantly increases when NaCl was added. Cerein 8A was effectively extracted into the micelle-rich phase in a 4% Triton X-114 medium. Recovery yield was higher for ATPS compared to ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5619220 Thu, 19 Jan 2012 05:00:00 +0100 5619220 http://www.medworm.com/index.php?rid=5619219&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22260222%26dopt%3DAbstract Authors: Agnihotri S, Wakode S, Ali M Abstract Hydrodistilled oil obtained from the stem bark of Myrica esculenta Buch. Ham. ex D. Don (yield 0.3%) was analysed by capillary GC and GC-MS. The volatile oil consisted mainly of n-hexadecanol (25.2%), eudesmol acetate (21.9%), palmitic acid (11.6%), cis-β-caryophyllene (8.7%), n-pentadecanol (7.7%) and n-octadecanol (7.6%). The oil was found to be a potential antimicrobial agent against Bacillus pumilus, Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Aspergillus niger and Saccharomyces cerevisiae. The essential oil exhibited significant topical anti-inflammatory activity compared to standard drug in Swiss albino mice ear. PMID: 22260222 [PubMed - as supplied by publis... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5619219 Thu, 19 Jan 2012 05:00:00 +0100 5619219 http://www.medworm.com/index.php?rid=5619218&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22260251%26dopt%3DAbstract Authors: Nguyen MT, Nguyen NT Abstract From the MeOH extract of the stem of Tetracera scandens L., a new nor-lupane triterpene, 28-O-β-D-glucopyranosyl ester of platanic acid (1), has been isolated together with six known compounds. Their structures were elucidated on the basis of spectroscopic data. Compounds 1-6 displayed significant xanthine oxidase inhibitory activity in a concentration-dependent manner, and compound 4 showed more potent inhibitory activity with an IC(50) value of 1.9 µM than that of a positive control allopurinol (IC(50) 2.5 µM). PMID: 22260251 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5619218 Thu, 19 Jan 2012 05:00:00 +0100 5619218 http://www.medworm.com/index.php?rid=5619221&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22250751%26dopt%3DAbstract In this study, we prepared crude fibre samples from young fruits of 10 persimmon (Diospyros kaki) cultivars and from young fruits of Japanese pear (Pyrus pyrifolia var. culta) and peach (Prunus persica) and compared their bile acid-binding abilities in vitro. All crude fibre samples from young fruits of persimmon were able to bind to cholic acid in a 4 mM cholic acid solution, but crude fibre samples from young fruits of Japanese pear and peach did not show bile acid-binding ability. The bile acid-binding ability was strongly correlated with the water-insoluble condensed tannins content in crude fibre samples (r = 0.909, p < 0.001). These results indicate that the water-insoluble condensed tannins content in young fruits of persimmon is related to its bile acid-binding abilit... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5619221 Wed, 18 Jan 2012 05:00:00 +0100 5619221 http://www.medworm.com/index.php?rid=5619223&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22250599%26dopt%3DAbstract Authors: Mozdianfard M, Akhbari M, Batooli H Abstract Antioxidant activities of different extracts obtained from the aerial parts of Vitex pseudo-negundo from Kashan, central Iran, were evaluated for the first time in this study using β-carotene/linoleic acid and scavenging of free-radical (DPPH) assays. Water extract showed the highest activity in both assays. GC-MS analysis of the oil extracted by n-hexane revealed 46 compounds with trans-β-farnesene being the main component. Several new compounds, not reported in the previous literature, were identified in the essential oil of this chemo-type. PMID: 22250599 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5619223 Tue, 17 Jan 2012 05:00:00 +0100 5619223 http://www.medworm.com/index.php?rid=5619222&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22250700%26dopt%3DAbstract This study investigated the pharmacokinetics of hesperidin (HP), ferulic acid (FA) and p-coumaric acid (CA) in rat plasma after oral administration of Portulaca oleracea L. extract (POE). The plasma concentrations were determined by HPLC with vitexin-2″-O-rhamnoside (VR) as internal standard. The calibration curves were linear over the range 0.1-5 µg mL(-1), 0.1-5 µg mL(-1)and 0.015-3 µg mL(-1) for HP, FA and CA, respectively. The validated method was suitable to the pharmacokinetic study of HP, FA and CA in rats after oral administration at a single dose of POE. PMID: 22250700 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5619222 Tue, 17 Jan 2012 05:00:00 +0100 5619222 http://www.medworm.com/index.php?rid=5595566&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22239172%26dopt%3DAbstract Authors: da Silva JV, Fill TP, da Silva BF, Rodrigues-Fo E Abstract In our continuous studies on the chemistry of the endophytic fungus Penicillium griseoroseum, an endophyte isolated from fruits of Coffea arabica, we isolated clavatol, a dimethylated tetraketide, and its dimer which appears to be a novel natural compound. The studies also resulted in the identification of two known tetronic acids, viridicatic acid and terrestric acid, found in ethyl acetate and n-butanol extracts. Spectroscopic studies using 1-D and 2-D NMR and MS/MS analysis were performed to determine the structures of these compounds, first reported by this Penicillium. Two other tetronic acids congeners were identified through HPLC/MS/MS studies, based on fragmentation pattern of ions produced from ionised tet... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5595566 Thu, 12 Jan 2012 05:00:00 +0100 5595566 http://www.medworm.com/index.php?rid=5595565&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22239222%26dopt%3DAbstract This study suggests that the δ-lactam derivative has the potential to be used as a lead compound in the development of anti-allergic drugs for clinical use in humans. PMID: 22239222 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5595565 Thu, 12 Jan 2012 05:00:00 +0100 5595565 http://www.medworm.com/index.php?rid=5595574&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22235912%26dopt%3DAbstract In this study, a series of dehydroabietylamine derivatives containing tricyclic diterpene structures were synthesised through oxidation in the 7th position of ring B and nitrification in the 12th position of ring C using dehydroabietylamine as the starting material. Structures of the synthesised compounds were confirmed by IR, (1)H-NMR, (13)C-NMR, MS and HRMS. The cytotoxicities of these compounds against PC-3 (human prostate carcinoma cell line) and Hey-1B (human ovarian carcinoma cell line) cells by the MTT assay were investigated. The results showed that the presence of a nitro group at 12th position and a carbonyl group at 7th position resulted in an increase of cytotoxic activity. Our findings present more evidence, showing the relationship between the chemical structure and biologica... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5595574 Wed, 11 Jan 2012 05:00:00 +0100 5595574 http://www.medworm.com/index.php?rid=5595573&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22235932%26dopt%3DAbstract In this study, diosgenin could significantly inhibit the growth of sarcoma-180 tumour cells in vivo, and remarkably increase thymus and spleen weights of S-180-bearing mice and upgrade the secretion level of TNF-α in serum. Moreover, diosgenin could stimulate lymphocyte transformation and enhance phagocytic capability of macrophages in vitro, and remarkably promoted the secretion of NO and TNF-α in macrophages. These results suggested that diosgenin could improve both specific and non-specific cellular immune responses, and the anti-tumour effects of diosgenin were achieved by immunostimulating properties instead of direct cytotoxicity. PMID: 22235932 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5595573 Wed, 11 Jan 2012 05:00:00 +0100 5595573 http://www.medworm.com/index.php?rid=5595572&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22235967%26dopt%3DAbstract Authors: da Cruz RC, Agertt V, Boligon AA, Janovik V, Anraku de Campos MM, Guillaume D, Athayde ML Abstract The total phenolic content (Folin-Ciocalteu) of the leaves of Ficus benjamina and Ficus luschnathiana was evaluated and screened by HPLC-DAD. Ficus luschnathiana crude extract (CE) presented phenolic content higher than that of F. benjamina (149.92 ± 3.65 versus 122.63 ± 2.79 mg of GAE). Kaempferol (1.63 ± 0.16 mg g(-1) dry weight of CE) and chlorogenic acid (17.77 ± 0.57 mg g(-1) of butanolic fraction) were identified and quantified in F. benjamina, whereas rutin (1.39 ± 0.20 mg g(-1)), caffeic (1.14 ± 0.13 mg g(-1)) and chlorogenic (3.73 ± 0.29 mg g(-1)) acids were quantified in the CE of F. luschnathiana. Additionaly... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5595572 Wed, 11 Jan 2012 05:00:00 +0100 5595572 http://www.medworm.com/index.php?rid=5595571&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236017%26dopt%3DAbstract Authors: Ao M, Liu B, Wang L Abstract The flower volatile compounds (FVCs) of two tetraploid Freesia hybrida (pink-yellow and yellow) cultivars and their cut flowers were analysed by headspace solid-phase microextraction combined with gas chromatography-mass spectrometry. Twelve FVCs were identified in the pink-yellow cultivar, with linalool as the major compound; 30 FVCs were identified in the yellow cultivar, with linalool and terpineol as the two major compounds. The FVCs (>1%) of the two cut flower cultivars were very similar to that of the un-cut flowers, and no significant difference was observed. PMID: 22236017 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5595571 Wed, 11 Jan 2012 05:00:00 +0100 5595571 http://www.medworm.com/index.php?rid=5595570&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236049%26dopt%3DAbstract Authors: Plastina P, Fazio A, Gabriele B Abstract The extracts of seven Citrus rootstock seeds have been compared regarding fatty acid profile and antioxidant potential. Sour orange (Citrus aurantium L.) was found to contain the highest oil amount (34%), while the Poncirus trifoliata cultivars contained the highest percentage of unsaturated fatty acids (84-87%). In addition, the antioxidant properties of the extracts from defatted seeds have been evaluated by measuring their radical scavenging activity against 2,2'-diphenyl-1-picrylhydrazyl. The highest antioxidant activities were observed in the case of the acetone extract of sour orange and Citrumelo Swingle (76% and 75%, respectively), at a concentration of 0.17 mg mL(-1). Moreover, the total phenolic content of the extracts... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5595570 Wed, 11 Jan 2012 05:00:00 +0100 5595570 http://www.medworm.com/index.php?rid=5595569&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236074%26dopt%3DAbstract Authors: Pejin B, Kien-Thai Y, Stanimirovic B, Vuckovic G, Belic D, Sabovljevic M Abstract The content of various heavy metals (arsenic, cadmium, chromium, copper, iron, lead, mercury, nickel, manganese and zinc) in the moss species Rhodobryum ontariense (Kindb.) Kindb. and its tea are presented in this study. Pursuant to the use of this tea in traditional Chinese medicine for hypertension, the aim of this study was to examine its safety in regard to the metals. All heavy metals were determined by adequate EPA methods. The concentrations of all metals for daily intake in its tea were below the safety levels for human consumption. These results indicate the importance of manganese in R. ontariense tea traditionally used for hypertension and other heart disorders. PMID: 22236074 ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5595569 Wed, 11 Jan 2012 05:00:00 +0100 5595569 http://www.medworm.com/index.php?rid=5595568&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236093%26dopt%3DAbstract Authors: D'Auria M, Racioppi R, Rana GL Abstract Volatile organic compounds of Schenella pityophilus have been identified via solid-phase microextraction-gas chromatography-mass spectrometry analysis. Ten compounds have been identified, in which 3-methylthio-1-propene was the most significant component. Some other components were previously identified in Tuber aestivum and Tuber melanosporum. PMID: 22236093 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5595568 Wed, 11 Jan 2012 05:00:00 +0100 5595568 http://www.medworm.com/index.php?rid=5595567&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22236131%26dopt%3DAbstract Authors: Gabriele B, Fazio A, Carchedi M, Plastina P Abstract The antioxidant properties of extracts of Sybaris liquorice roots have been assessed using 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. The extracts, obtained by Soxhlet extraction (Et(2)O, AcOEt, MeOH and BuOH) of the yellow (inner part) and brown (cortex) root powders ensuing from decortication of the raw dry roots, followed by separation and powderisation, were analysed for their scavenging activity by evaluating the colourimetric decrease in the absorbance of DPPH. The highest antioxidant activity (98.39 ± 0.56%) was observed in the case of the Et(2)O extract of the brown powder, at a concentration of 3.33 mg mL(-1). Moreover, the total phenolic content of the extracts was determi... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5595567 Wed, 11 Jan 2012 05:00:00 +0100 5595567 http://www.medworm.com/index.php?rid=5595575&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22233192%26dopt%3DAbstract Authors: Ozcan T Abstract Accumulation profiles of fatty acids and α-tocopherol were analysed at three ripening stages in the seed oils of Primula and Echium species. Total seed oils were increased considerably with maturation, while α-tocopherol contents decreased in both species. Increased levels of ALA and oleic acid, and decrease in linoleic and palmitic acids at late ripening stages of Primula sibthorpii, and slightly fluctuations of all examined fatty acids in Echium italicum were observed. Considerable amounts of α-tocopherol (27.4 mg/100 g), linoleic acid (42.76%) and ALA (25.46%) and GLA (4.11%) were detected in Ribes alpinum. Typical accumulation patterns of the examined parameters may be useful for species characterisation and biochemical monitoring of seed develo... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5595575 Tue, 10 Jan 2012 05:00:00 +0100 5595575 http://www.medworm.com/index.php?rid=5545000&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22191514%26dopt%3DAbstract Authors: Guerra FQ, Mendes JM, Sousa JP, Morais-Braga MF, Santos BH, Melo Coutinho HD, Lima ED Abstract The genus Acinetobacter has gained importance in recent years due to involvement in serious infections and antimicrobial resistance. Many plants have been evaluated not only for direct antimicrobial activity, but also as resistance modifying agents. The Essential oil of Citrus limon (EOCL) addition at 156.25 µgmL(-1) (MIC/8) sub-inhibitory concentration in the growth medium led to MIC decrease for amikacin, imipenem and meropenem. The Essential oil of Cinnamomum zeylanicum (EOCZ) addition at 78.125 µg mL(-1) (MIC/8) sub-inhibitory concentrations in the growth medium caused drastic MIC reduction of amikacin. Results of combining antibiotics and essential oils had shown us ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5545000 Fri, 23 Dec 2011 05:00:00 +0100 5545000 http://www.medworm.com/index.php?rid=5545001&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22188569%26dopt%3DAbstract Authors: Balachandra BA, Pathirathna PU, Paranagama PA Abstract The bruchid, Callosobruchus maculatus (F.) causes major losses during the storage of cowpea seeds [Vigna unguiculata (L.)Walp.] in Sri Lanka. Essential oil isolated from Plectranthus zeylanicus plant was tested for potential insecticidal activity against C. maculatus. The gas chromatography studies of the essential oil of P. zeylanicus showed that ρ-cymene (3.5%), β-caryophyllene (0.2%), geranyl acetate (9.3%) and geraniol (7.2%) were the major constituents. The adults of C. maculatus were susceptible to both fumigant and contact toxicity of P. zeylanicus plant oil. LC(50) values of 0.927 and 0.010 g L(-1) were obtained for fumigant toxicity and contact toxicity assays, respectively. Oviposition and F(1) adult em... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5545001 Wed, 21 Dec 2011 05:00:00 +0100 5545001 http://www.medworm.com/index.php?rid=5526978&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22181707%26dopt%3DAbstract Authors: Ghalib RM, Hashim R, Sulaiman O, Mehdi SH, Anis Z, Rahman SZ, Ahamed BM, Abdul Majid AM Abstract The leaves of Cinnamomum iners (Reinw. ex Blume-Lauraceae) have been refluxed successively with chloroform and alcohol to get chloroform extract and alcoholic extract. Both the extracts have been assayed for cytotoxicity against human colorectal tumour cells. The chloroform extract exhibited significant cytotoxicity with IC(50) 31 µg mL(-1) (p < 0.01). However, ethanol extract was found to be much less cytotoxic with IC(50) > 200 µg mL(-1). The chloroform extract has been further proceeded for chemical analysis by GC-TOFMS and 178 components were identified including acids, amines, amides, aldehydes, alcohols, esters, benzene derivatives, bicyclic compounds,... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5526978 Mon, 19 Dec 2011 05:00:00 +0100 5526978 http://www.medworm.com/index.php?rid=5526977&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22181835%26dopt%3DAbstract Authors: Mahlke JD, Boligon AA, Machado MM, Athayde ML Abstract Alzheimer's disease (AD) is a neurodegenerative disorder resulting in impaired memory and behaviour of remarkable socio-economic impact. A decrease in cholinergic activity is a key event in the biochemical of AD. Buddleja thyrsoides is a plant widely distributed in Southern parts of South America. In Brazilian traditional medicine, the infusion of its leaves and flowers is used for the treatment of bronchitis and cough. Crude ethanolic (70%) extract and fractions (dichloromethane, ethyl acetate and n-butanolic) were investigated regarding their toxicities in vitro and antiplatelet action. The enzyme acetylcholinesterase inhibition was evaluated to study the crude extract. The crude extract and fractions were evaluated... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5526977 Mon, 19 Dec 2011 05:00:00 +0100 5526977 http://www.medworm.com/index.php?rid=5507103&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22165850%26dopt%3DAbstract In this study, 1,8-cineole, camphre, camphene α-pinene and β-pinene were identified as the major components of sage leaves collected at different periods. The main constituents of sage oil collected over the years were 1,8-cineole (35.01-48.06%), camphre (13.58-23.92%), camphene (6.77-8.82%), α-pinene (5.79-8.54%) and β-pinene (4.32-6.28%). PMID: 22165850 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5507103 Wed, 14 Dec 2011 05:00:00 +0100 5507103 http://www.medworm.com/index.php?rid=5507102&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22168240%26dopt%3DAbstract Authors: Adewuyi A, Oderinde RA, Rao BV, Prasad RB Abstract Proximate composition of the seeds and chemical analysis of the oils of Lonchocarpus sericeus and Lonchocarpus cyanescens were determined. The oil content of the seed of L. cyanescens is 29.71 ± 0.20% while that of L. sericeus is 28.00 ± 0.50%. The seeds as well as the oils of L. cyanescens and L. sericeus were found to be rich in K, Na and Fe. Linolenic (C18:3) and oleic (C18:1) acid are the dominant fatty acids while the neutral lipids the dominant lipid class in the oils. Phytol, sterols, beta-tocopherol and hydrocarbons were identified in the unsaponifiable matters of the oils using GC-MS. The HPLC results revealed the presence of glycolipids, which are monogalactosyldiacylglycerol, digalactosyldiacylglycerol... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5507102 Wed, 14 Dec 2011 05:00:00 +0100 5507102 http://www.medworm.com/index.php?rid=5507101&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22168262%26dopt%3DAbstract Authors: Saab AM, Lampronti I, Borgatti M, Finotti A, Harb F, Safi S, Gambari R Abstract There are four kinds of Cedar: Cedrus libani naturally occurring in Lebanon, Syria and Turkey, Cedrus atlantica in Morocco and Algeria, Cedrus brevefolia in Cyprus Island and Cedrus deodara which is distributed in Himalayan Mountains. Wood essential oils obtained from C. libani, C. atlantica and C. deodara were tested for the inhibition of K562 cell proliferation and for the induction of erythroid differentiation. The wood essential oils of C. libani, C. atlantica and C. deodara inhibited the proliferation of the K562 cell line exhibiting IC(50) values 23.38 ± 1.7, 59.37 ± 2.6 and 37.09 ± 1.4 µg mL(-1), respectively. Meanwhile, C. libani wood oils induced a percentage of ery... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5507101 Wed, 14 Dec 2011 05:00:00 +0100 5507101 http://www.medworm.com/index.php?rid=5507100&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22168302%26dopt%3DAbstract Authors: Satyan RS, Sakthivadivel M, Shankar S, Dinesh MG Abstract Excoecaria agallocha Linn. the blinding mangrove tree of historical significance, is well known for its curative properties. In this investigation, crude hexane extract from the dried roots of E. agallocha inhibited 50% of the growth of third instar larvae of Culex quinquefasciatus Say. within 24 h (LC(50): 315 ppm). SiO(2) (60-120) column chromatography purification of the extract yielded four fractions, of which fractions 3 (LC(50): 61.2 ppm) and 4 (LC(50): 74.5 ppm) exhibited 100% larvicidal activity within 18-24 h. Bioactive fraction 3 contained sub-fractions R1 and R2. R1 was characterised by (1)H-NMR, (13)C-NMR and FAB mass spectrometry techniques as the acyclic hydrocarbon n-triacontane (C(30)H(62))... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5507100 Wed, 14 Dec 2011 05:00:00 +0100 5507100 http://www.medworm.com/index.php?rid=5507099&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22168341%26dopt%3DAbstract Authors: Xu K, Jiang S, Sun H, Zhou Y, Xu X, Peng S, Ding L Abstract Three new alkaloids, N-hexacosanoylanthranilic acid (1), N-octacosanoylanthranilic acid (2) and N-eicosanoyltyramine (3), along with 19 known compounds, were isolated from the seeds of Notopterygium incisum, whose rhizomes are used as a traditional Tibetan medicine. Their structures were elucidated by 1D, 2D NMR spectra and ESI-MS spectrometer evidence. PMID: 22168341 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5507099 Wed, 14 Dec 2011 05:00:00 +0100 5507099 http://www.medworm.com/index.php?rid=5507104&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22150026%26dopt%3DAbstract Authors: Batista EF, Costa DM, Guilhon GM, Muller AH, Santos LS, Arruda MS, Arruda AC, Silva MN, Silva JK, Secco RS, Souza Filho AP, Figueira BA Abstract Chemical investigation of extracts from the stems and leaves of Alchorneopsis floribunda Müll. Arg., collected in the Amazon region, was performed. The main isolated compounds were triterpenes (α-amyrin, β-amyrin, lupeol, betulin, betulinic acid, uvaol, erythrodiol and oleanolic acid) and phenolic acid derivatives from 4-hydroxybenzoic acid (gallic and protocatechuic acids and isocorilagin). In the germination assays, high inhibitory allelopathic effects of the extracts and isocorilagin were observed and 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity of isocorilagin was higher than those of the standards used (Trolox... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5507104 Mon, 12 Dec 2011 05:00:00 +0100 5507104 http://www.medworm.com/index.php?rid=5507105&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22149976%26dopt%3DAbstract Authors: Jürgenson S, Matto V, Raal A Abstract Epilobium angustifolium L. herbs are used in ethnomedicine to treat benign prostate hyperplasia. The aim of the study was to investigate the phenolic contents in distinct E. angustifolium organs during the whole vegetational period from May to October. The plants were obtained from a remote habitat in Estonia and spectrophotometrically analysed for the total polyphenol, tannin, and flavonoid contents. The total polyphenol content was the highest in roots (85 mg g(-1)) and stems (67 mg g(-1)) in July. The total flavonoid content was the highest in leaves (2.36 mg g(-1)) and flowers (2.09 mg g(-1)) and it remained relatively stable during the summer months. The highest tannin content was found in small growing plants in ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5507105 Fri, 09 Dec 2011 05:00:00 +0100 5507105 http://www.medworm.com/index.php?rid=5507107&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22149904%26dopt%3DAbstract Authors: Couteau C, Cheignon C, Paparis E, Coiffard LJ Abstract Some UV-filters have side effects. For example, oestrogenic effect was demonstrated for 4-methylbenzylidene camphor. Given that secondary metabolites are known for their UVB photoprotective properties in plants that contain them, we chose to study silymarin as an agent which could potentially be used in sun products. This determination is based on the physical determination of the reduction of the energy in the UV range, through a film of product which has previously been spread on an adequate substrate. About 15 mg of O/W emulsion containing silymarin at various concentrations was applied on roughened PMMA plates and the transmission measurements were carried out using a spectrophotometer equipped with integrating s... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5507107 Thu, 08 Dec 2011 05:00:00 +0100 5507107 http://www.medworm.com/index.php?rid=5507106&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22149942%26dopt%3DAbstract Authors: Zhang X, Wei N, Huang J, Tan Y, Jin D Abstract A new feruloyl amide derivative, named tribulusamide C, was isolated from the fruits of Tribulus terrestris. Its structure was determined on the basis of spectroscopic analysis including IR, 1-D-, 2-D-NMR and HR-ESI-MS. The structure of tribulusamide C was characterised by a unit of pyrrolidine-2,5-dione, which distinguished it from other lignanamides previously isolated from the fruits of T. terrestris. PMID: 22149942 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5507106 Thu, 08 Dec 2011 05:00:00 +0100 5507106 http://www.medworm.com/index.php?rid=5472678&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22132692%26dopt%3DAbstract Authors: Manoj G, Manohar SH, Murthy HN Abstract The essential oil extracted from the leaves of Pogostemon paniculatus (Willd.) Benth. (Lamiaceae), was analysed by gas chromatography-mass spectrometry (GC-MS). Nineteen compounds constituting 85.36% of the total oil were identified in the oil. Patchouli alcohol (30.65%), α-guaiene (10.67%), β-guaiene (9.09%), caryophyllene (8.64%), eicosene (5.27%) were the major constituents present. The essential oil was analysed for antimicrobial activity by disc diffusion assay and minimum inhibition concentration against six bacteria and three fungi. Results showed inhibitory activity against some of the tested microorganisms. The essential oil was also tested for the DPPH free-radical scavenging activity and had an inhibitory concentration (... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472678 Fri, 02 Dec 2011 05:00:00 +0100 5472678 http://www.medworm.com/index.php?rid=5472677&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22132714%26dopt%3DAbstract Authors: Ozcan MM, Unver A, Gümüş T, Akın A Abstract Percentages of crude oil, protein, fibre and ash of grape seeds obtained from Turkish cultivars were of the ranges 5.40-10.79, 5.24-7.54, 17.6-27.1, and 1.2-2.6, respectively. The highest crude oil, crude protein and crude fibre were determined in Siyah pekmezlik, Karadimrit and Antep grape seeds. The energy values of seeds were established to be between 102.28 and 148.07 kcal g(-1). Potassium and calcium contents of seed samples were found to be at high levels compared to sodium. The seeds contained 686-967 ppm of Na, 2468-3618 ppm of K and 2373-4127 ppm of Ca. The refractive index, relative density, acidity, saponification value, unsaponifiable matter and iodine value of seed oils were determined to be in the rang... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472677 Fri, 02 Dec 2011 05:00:00 +0100 5472677 http://www.medworm.com/index.php?rid=5472676&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22132736%26dopt%3DAbstract In this study, we have demonstrated that R. tripartitum extracts exhibited a significant broad spectrum activity against one or more of the test microorganisms with a zone size ranging from 8 to 28 mm in diameter. These diameters are much higher than those obtained with standard antibiotics. The chloroformic extracts were found to be effective against bacterial and fungal strains tested, with MIC values ranging between 0.07 and 0.62 mg mL(-1) against Staphylococcus aureus and Candida albicans. However, ethyl-acetate/methanol fractions showed a selective activity only against bacterial microorganisms with low MIC values between 0.07 and 0.15 mg mL(-1). The overall results suggested that the traditional use of R. tripartitum for the treatment of diarrhoea tract infections was attri... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472676 Fri, 02 Dec 2011 05:00:00 +0100 5472676 http://www.medworm.com/index.php?rid=5472675&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22132759%26dopt%3DAbstract In this study, 10 already described secondary metabolites and 2 unknown metabolites were identified in an extract of Monascus purpureus by high-performance liquid chromatography-diode array detection. The unknown metabolites were isolated and their chemical structures were elucidated. The new metabolites possess the molecular formulas C(21)H(27)NO(4) and C(23)H(31)NO(4). They were named monascopyridines E and F due to their pyridine backbone. The cytotoxicity of the new compounds was studied using immortalised human kidney epithelial cells displaying IC(50) values in the micromolar range. PMID: 22132759 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472675 Fri, 02 Dec 2011 05:00:00 +0100 5472675 http://www.medworm.com/index.php?rid=5472680&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22124231%26dopt%3DAbstract In this study, the chemical composition of the essential oil from A. wiedemanniana was evaluated and its antibacterial activity was tested against 10 bacterial strains. The oil was also tested for its potentiality to inhibit nitric oxide production in RAW 264.7 macrophages and for its cytotoxicity against four human cancer cell lines. A. wiedemanniana oil, rich of oxygenated monoterpenes (25.4%), showed a good antibacterial activity against Gram-positive bacteria and a good activity against the two Gram-negative bacteria, Escherichia coli and Proteus vulgaris. Besides that, it exhibited a high inhibitory effect on the LPS-induced nitrite production and a strong cytotoxic activity, especially against amelanotic melanoma (C32) and large lung cell carcinoma (COR-L23) cell lines. PMID: 221... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472680 Tue, 29 Nov 2011 05:00:00 +0100 5472680 http://www.medworm.com/index.php?rid=5472679&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22124275%26dopt%3DAbstract Authors: Yan-Yun C, Liang Z, Ning L, Ke-Wu Z, Peng-Fei T Abstract Two new triterpenoid saponins, ilemaminosides A and B (1 and 2) along with six known saponins (3-8) were isolated from 70% ethanolic extract of the leaves of Ilex mamillata C.Y. Wu ex C.J. Tseng. The new saponins were characterised as 3-O-α-L-arabinopyranosyl-ilexgenin B (1) and 3-O-β-D-glucopyranosyl-(1 → 3)-α-L-arabinopyranosyl-ilexgenin B (2). The structures of compounds 1 and 2 were elucidated on the basis of the chemical and spectroscopic methods, and the structures of known compounds were identified by comparison of their spectroscopic data with those reported in the literature. The compounds showed inhibitory activities in anti-inflammatory assay in vitro with IC(50) values in the range 25.37-38.33�... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472679 Tue, 29 Nov 2011 05:00:00 +0100 5472679 http://www.medworm.com/index.php?rid=5472681&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22122512%26dopt%3DAbstract This study reports the production and characterisation of a novel thermostable alkaline amylase from the newly isolated Geobacillus stearothermophilus HP 3. The optimum temperature and pH for enzyme production was 55°C and 9.0, respectively. The amylase powder obtained from the culture filtrate by pre-chilled acetone treatment was stable over a wide pH range and liquefied thick starch slurries at 75°C. Ca(2+) and Co(2+) were required for the thermostability of the enzyme preparation. The present purified amylase therefore could be defined as thermostable and alkalitolerant with new properties that make the enzyme applicable for many starch processing applications for use in the food industry. PMID: 22122512 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472681 Mon, 28 Nov 2011 05:00:00 +0100 5472681 http://www.medworm.com/index.php?rid=5472691&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22115413%26dopt%3DAbstract This study is designed to examine the chemical composition of the essential oil and antioxidant activities of the different extracts of Tanacetum sonbolii Mozaff. from Iran for the first time. The essential oil was isolated by hydrodistillation and its gas chromatography and gas chromatography-mass spectrometry analyses resulted in the identification of 26 components, representing 96.5% of the oil. The major components were characterised to be α-cadinol (35.3%), globulol (20.1%) and 1,8-cineole (8.6%). Antioxidant activities of the various extracts of the plant were determined by two different test systems; 1,1-diphenyl-2-picrylhydrazyl (DPPH) and β-carotene-linoleic acid. Also, their total phenolic and flavonoid contents were determined. DPPH radical-scavenging activities of test sample... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472691 Fri, 25 Nov 2011 05:00:00 +0100 5472691 http://www.medworm.com/index.php?rid=5472690&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22115452%26dopt%3DAbstract Authors: Xu J, Guo P, Guo Y, Fang L, Li Y, Sun Z, Gui L Abstract A new iridoid, jatamandoid A (1), and four known analogues (2-5) were isolated from the roots of Valeriana jatamansi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, ESI-MS, HR-ESI-MS, 1-D and 2-D NMR). Five compounds were evaluated and compounds 1, 2 and 5 showed moderate neuroprotective effects against MPP(+)-induced neuronal SH-SY5Y cell death. PMID: 22115452 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472690 Fri, 25 Nov 2011 05:00:00 +0100 5472690 http://www.medworm.com/index.php?rid=5472689&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22117104%26dopt%3DAbstract Authors: Nana F, Sandjo LP, Keumedjio F, Kuete V, Ngadjui BT Abstract A new aldol ester named 17-O-triacontanoylheptadecanal (1) was isolated from the aerial part of Mimosa invisa (Mimosaceae) together with eight known compounds identified as β-sitosterol (2), α-amyrine (3), lupeol (4), 4'-O-methylepinumisoflavone (5), alpinumisoflavone (6), betulinic acid (7), 3-O-β-D-glucopyranoside of sitosterol (8) and epirobinetinidol (9). The structures of compounds were determined on the basis of NMR and mass spectrometry data as well as by comparing the data reported in the literatures. The antimicrobial activities of the crude extract and compounds 1 and 9 were investigated against seven microbial species. The natural products showed moderate activities compared to that of the crude ext... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472689 Fri, 25 Nov 2011 05:00:00 +0100 5472689 http://www.medworm.com/index.php?rid=5472688&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22117109%26dopt%3DAbstract Authors: Razavi SM Abstract Prangos pabularia Lindl. (Apiaceae) is a widespread perennial herb distributed from Russia to Iran, Turkey, India, Central Asia and Caucasian. It has been used in folk medicine from ancient times as a diuretic agent and a treatment for leukoplakia, digestive disorders, healing scars and stopping bleeding. In the present study, the composition of the essential oils isolated from leaves, fruits and umbels of this plant was analyzed using GC-MS. The results showed that the leaves' oil was dominated by sesquiterpene derivatives with spathulenol (16.09%) and α-bisabolol (14.30%) as major components. The fruits and umbels oil were characterized by monoterpenes comprised of α-pinene (33.87, 21.46%) as the main compound. The essential oil of the plant leaves e... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472688 Fri, 25 Nov 2011 05:00:00 +0100 5472688 http://www.medworm.com/index.php?rid=5472687&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22117113%26dopt%3DAbstract Authors: Nobsathian S, Tuchinda P, Soorukram D, Pohmakotr M, Reutrakul V, Yoosook C, Kasisit J, Napaswad C Abstract Bioassay-guided fractionation and purification of the aerial parts of Piper submultinerve led to the isolation of a new conjugated amide-dimer, submultinamide A (1), along with 11 known compounds. The structures were determined on the basis of spectroscopic methods. Among the tested compounds, pellitorine (2), guineensine (4), N-benzylcinnamide (6) and aristolactam BII (8) showed significant activities in the anti-syncytium assay using (ΔTat/Rev)MC99 virus and 1A2 cell line system, whereas 2 was most active (EC(50) 35.1 µM and selectivity index 4.7). In the HIV-1 reverse transcriptase assay, only 4 was active with IC(50) 50.8 µM. PMID: 22117113 [PubMed - as... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472687 Fri, 25 Nov 2011 05:00:00 +0100 5472687 http://www.medworm.com/index.php?rid=5472686&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22117129%26dopt%3DAbstract Authors: Messaoud C, Chograni H, Boussaid M Abstract A comparative study of essential oil composition, polyphenol content and antioxidant activities of Lavandula coronopifolia, Lavandula multifida and Lavandula stoechas subsp. stoechas were reported. Qualitative and quantitative variations in the composition of oils according to species were shown. Lavandula coronopifolia's oil was characterised by high proportions of trans-β-ocimene (26.9%), carvacrol (18.5%), β-bisabolene (13.1%) and myrcene (7.5%). The main components of L. multifida oil are carvacrol (65.1%) and β-bisabolene (24.7%). Lavandula stoechas oil is rich in fenchone (34.3%) and comphor (27.4%). The total phenolic and flavonoid contents also significantly varied among species. Lavandula coronopifolia exhibits the hi... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472686 Fri, 25 Nov 2011 05:00:00 +0100 5472686 http://www.medworm.com/index.php?rid=5472685&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22117164%26dopt%3DAbstract Authors: Koolen HH, Soares ER, da Silva FM, Lima de Souza AQ, de Medeiros LS, Filho ER, de Almeida RA, Ribeiro IA, do Ó Pessoa C, de Morais MO, da Costa PM, de Souza AD Abstract From an endophytic strain of Gliocladium sp. isolated from the Amazonian plant Strychnos cf. toxifera, we obtained the diketopiperazine alkaloid cyclo-(glycyl-L-tyrosyl)-4,4-dimethylallyl ether (1), the steroids ergosterol (2), ergosterol peroxide (3), cerevisterol (4) and the citric acid (5). The AcOEt extract of the fermented broth by Gliocladium sp. showed potent activity against the cancer cell lines MDA-MB435 (human breast cancer cells), HCT-8 (human colorectal cancer cells) and SF-295 (human glioblastoma cancer cells). Compound 1 exhibited a strong antimicrobial activity against Micrococcus luteus at... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472685 Fri, 25 Nov 2011 05:00:00 +0100 5472685 http://www.medworm.com/index.php?rid=5472684&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22117188%26dopt%3DAbstract Authors: Hiranrat A, Chitbankluoi W, Mahabusarakam W, Limsuwan S, Voravuthikunchai SP Abstract A new flavellagic acid derivative, 3,3',4,4'-tetra-O-methylflavellagic acid and six known compounds were isolated from the stems of Rhodomyrtus tomentosa while a new phloroglucinol, named rhodomyrtosone I, and six known compounds were isolated from the fruit. Their structures were elucidated by spectroscopic analyses as well as by comparisons with related compounds. PMID: 22117188 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472684 Fri, 25 Nov 2011 05:00:00 +0100 5472684 http://www.medworm.com/index.php?rid=5472683&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22117190%26dopt%3DAbstract In this study, essential oil compositions of two Hypericum L. taxa (Hypericum triquetrifolium Turra. and Hypericum aviculariifolium Jaub. et Spach subsp. depilatum var. depilatum (Freyn et Bornm.) Robson) naturally grown in Turkey were determined using gas chromatography and gas chromatography-mass spectrometry systems. The essential oils were obtained by hydrodistillation from the aerial parts of plants. A total of 45 compounds were identified in the essential oils of H. triquetrifolium; 1-hexanal (18.8%), 3-methylnonane (12.5%) and α-pinene (12.3%). In this study, 41 components were identified in H. aviculariifolium subsp. depilatum var. depilatum oil; α-pinene (52.1%), germacrene D (8.5%) and β-pinene (3.6%) were the predominant constituents. The essential oil analysis showed that mo... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472683 Fri, 25 Nov 2011 05:00:00 +0100 5472683 http://www.medworm.com/index.php?rid=5472682&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22117193%26dopt%3DAbstract Authors: Kicel A, Wolbiś M Abstract The flowers and leaves of Trifolium repens L. (Fabaceae) were subjected to phytochemical investigation in order to identify their major chemical constituents and to evaluate in vitro antioxidant activity of the isolated compounds against DPPH˙. A total of 12 flavonoids, pterocarpan and methyl caffeate were isolated, then characterised by UV, MS, NMR spectroscopy and identified as quercetin and kaempferol 3-O-(6″-α-rhamnopyranosyl-2″-β-xylopyranosyl)-β-galactopyranosides (1, 2), kaempferol 3-O-(2″,6″-α-dirhamnopyranosyl)-β-galactopyranoside, mauritianin (3), quercetin and kaempferol 3-O-(2″-β-xylopyranosyl)-β-galactopyranosides (4, 5), kaempferol and quercetin 3-O-β-(6″-O-acetyl)-galactopyranosides (6, 7), trifolin (8), hype... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472682 Fri, 25 Nov 2011 05:00:00 +0100 5472682 http://www.medworm.com/index.php?rid=5472692&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22111591%26dopt%3DAbstract Authors: Padalia RC, Verma RS, Chauhan A, Chanotiya CS Abstract The leaf and root essential oil composition of Boenninghausenia albiflora Reichb and Meissner (family: Rutaceae), collected from Uttarakhand, India, was analysed by capillary gas chromatography and gas chromatography-mass spectrometry. The major constituents identified in the leaf essential oil were β-myrcene, (Z)-β-guaiene, (Z)-β-ocimene and β-caryophyllene, whereas bicyclogermacrene, α-terpinyl acetate, geijerene and β-copaene-4α-ol were identified as the major constituents of the root essential oil. This is the first time that the chemical compositions of leaf and root essential oils of B. albiflora have been investigated in detail. The results show significant qualitative and quantitative variations in leaf ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472692 Thu, 24 Nov 2011 05:00:00 +0100 5472692 http://www.medworm.com/index.php?rid=5472693&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22107457%26dopt%3DAbstract Authors: Li JT, Chen QQ, Zeng Y, Wang Q, Zhao PJ Abstract The strain DC01 was isolated from the branch tissue of Daphniphyllum longeracemosum and determined to be a member of Phomopsis according to the ITS sequence analysis. The extracts from the PDA solid fermentation media of Phomopsis sp. DC01 were purified and three compounds including one new phenol compound were obtained. The new compound was identified to be (E )-7-(2-hydroxy-4-(hydroxymethyl)phenyl)-2-methyloct-6-enoic acid (1) based on 1-D NMR, 2-D NMR and HR-ESI data. PMID: 22107457 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472693 Tue, 22 Nov 2011 05:00:00 +0100 5472693 http://www.medworm.com/index.php?rid=5472698&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22103287%26dopt%3DAbstract Authors: Naguib AM, Ebrahim ME, Aly HF, Metawaa HM, Mahmoud AH, Mahmoud EA, Ebrahim FM Abstract This research was performed to investigate in vitro the biological activities of successive as well as 70% ethanol extracts of Nepeta cataria on some biochemical parameters including oxidative markers and carbohydrate-hydrolysing enzyme activities (α-amylase, β-galactosidase and α-glucosidase). Powdered N. cataria and its successive extracts were screened for their phytochemical constituents. Tests for tannins, carbohydrates, glycosides and flavonoids were positive in ethanolic extract, but those for steroids and terpenoids were positive in petroleum ether and chloroform extracts. Also, different extracts were chromatographically investigated. The results obtained demonstrated that d... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472698 Mon, 21 Nov 2011 05:00:00 +0100 5472698 http://www.medworm.com/index.php?rid=5472697&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22103318%26dopt%3DAbstract Authors: Farimani MM, Moghaddam FM, Esmaeili MA, Amin G Abstract Phytochemical investigation of the aerial parts of Salvia eremophila led to the isolation of a lupane triterpenoid, 3β, 20-dihydroxylupane-28-oic acid (1), together with eight other compounds, comprising three diterpene, two triterpene, two flavonoids and a steroidal glucoside. Their structures were elucidated by interpretation of their one-dimensional and two-dimensional NMR spectra and completed by the analysis of the HRESIMS data. Compounds 1, 2-4 and 8 were evaluated for their cytotoxicities against five human tumour cell lines. Compounds 1 and 3 hold a good potential for use in future studies due to their anti-cancer properties. PMID: 22103318 [PubMed - as supplied by publisher] (Source: Natural Product Rese... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472697 Mon, 21 Nov 2011 05:00:00 +0100 5472697 http://www.medworm.com/index.php?rid=5472696&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22103340%26dopt%3DAbstract Authors: Xu W, Fang J, Zhu Z, Wu J, Li Y Abstract A new triterpenoid saponin, silenoviscoside F (1), was isolated from the roots of Silene viscidula, together with three known saponins, dianchinenoside D (2), sinocrassuloside I (3) and sinocrassuloside II (4). The structure of compound 1 was elucidated by spectroscopic data, GC-MS and chemical methods. The structures of compounds 2-4 were determined on the basis of spectroscopic data comparison with the literature values, which were isolated from the genus Silene for the first time. PMID: 22103340 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472696 Mon, 21 Nov 2011 05:00:00 +0100 5472696 http://www.medworm.com/index.php?rid=5472695&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22103398%26dopt%3DAbstract This study concluded that EOB and EOS were not only different in extraction yield but also in chemical composition and antioxidant activity. PMID: 22103398 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472695 Mon, 21 Nov 2011 05:00:00 +0100 5472695 http://www.medworm.com/index.php?rid=5472694&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22103437%26dopt%3DAbstract Authors: Rajamurugan R, Selvaganabathy N, Kumaravel S, Ramamurthy C, Sujatha V, Thirunavukkarasu C Abstract Profound research has been done on the medicinal value of Brassica nigra (BN) seeds, and the leaves of the plant have been investigated in this study. The methanol extracts of the leaves were subjected to several in vitro studies. The antioxidant activity of methanol extract was demonstrated with a wide range of concentration, 10-500 µg mL(-1), and the antioxidant activity increased with the increase in concentration. Total phenol content was found to be 171.73 ± 5.043 gallic acid equivalents and the total flavonoid content 7.45 ± 0.0945 quercetin equivalents. Further quantification and identification of the compounds were done by HPTLC and GC-MS analyses. The... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472694 Mon, 21 Nov 2011 05:00:00 +0100 5472694 http://www.medworm.com/index.php?rid=5472699&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22092272%26dopt%3DAbstract In this study, the neuroprotective potential and in vivo antioxidant status of extract of roots and rhizomes of Rubia cordifolia L (MERC) in reserpine-induced orofacial dyskinesia was studied. Reserpine (1 mg/kg, s.c.) on day 1, 3 and 5 was used to induce orofacial dyskinesia. At the end of treatment schedule, MERC significantly inhibited reserpine-induced vacuous chewing movements, tongue protrusions, orofacial bursts, catalepsy. MERC significantly increased locomotion and rearing in open field test. MERC exhibited significant elevation in the levels of superoxide dismutase, catalase, glutathione reductase and inhibition of lipid peroxidation in forebrain region, compared with the reserpine treated group. It significantly elevated dopamine levels in the forebrain region. GCMS revealed the... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5472699 Fri, 18 Nov 2011 05:00:00 +0100 5472699 http://www.medworm.com/index.php?rid=5414296&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22085357%26dopt%3DAbstract Authors: Shu JC, Chou GX, Wang ZT Abstract To investigate the chemical constituents of Psidium guajava L, the EtOH/H(2)O extract of the fresh leaves was subjected to various chromatography. One diphenylmethane, one benzophenone, and eight flavonoids were isolated and elucidated as 2,6-dihydroxy-3-formaldehyde-5-methyl-4-O-(6″-O-galloyl-β-D-glucopyranosyl)-diphenylmethane (1), 2,6-dihydroxy-3,5-dimethyl-4-O-(6″-O-galloyl-β-D-glucopyranosyl)-benzophenone (2), kaempferol (3), quercetin (4), quercitrin (5), isoquercitrin (6), guaijaverin (7), avicularin (8), hyperoside (9), reynoutrin (10) by spectroscopic methods, including 1D and 2D NMR and HR-ESI-MS spectrometry as well as by comparison with published data. Compounds 5 and 10 are obtained from P. guajava for the first time, an... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414296 Wed, 16 Nov 2011 05:00:00 +0100 5414296 http://www.medworm.com/index.php?rid=5414298&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22085305%26dopt%3DAbstract Authors: Bazylko A, Stolarczyk M, Derwińska M, Kiss AK Abstract Taking into account the role of reactive oxygen species in the development of inflammation, and the application of the plants of genus Galinsoga Ruiz & Pav. in folk medicines for inflammatory states, we investigated and compared the antioxidant activities of particular Galinsoga extracts and fractions. The compositions of the most active fractions were studied using thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC) methods. The extracts and fractions from Galinsoga parviflora Cav. and Galinsoga quadriradiata Ruiz et Pav. possess dose-dependent free radical-scavenging ability against DPPH(•) and superoxide radicals, as well as inhibitory effects on linoleic acid peroxidation in a m... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414298 Tue, 15 Nov 2011 05:00:00 +0100 5414298 http://www.medworm.com/index.php?rid=5414297&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22085324%26dopt%3DAbstract Authors: Tercan S, Seker M Abstract The solid fraction of olive mill waste water (OMWW) was separated from OMWW and then the solutes in the solid fraction of OMWW were extracted with ethanol. The detection of polyphenols in the ethanol extract showed the presence of polyphenols in the solid fraction of OMWW. Effects of solvent-to-solid ratio, extraction and agitation time on the extraction of polyphenols from the solid fraction of OMWW were examined and the maximum amount of polyphenol was extracted from the solid fraction of OMWW with a solvent-to-solid ratio of 15 at 70 min of extraction and 10 min of agitation time. Percent yields and purities of the polyphenols extracted from solid fraction of OMWW were higher than those of the polyphenols extracted from olive pomace with e... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414297 Tue, 15 Nov 2011 05:00:00 +0100 5414297 http://www.medworm.com/index.php?rid=5414301&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22077491%26dopt%3DAbstract Authors: Wang B Abstract Yield of trans-resveratrol from Pinot Noir-grape pomace obtained by microwave-assisted extraction (MAE) through an orthogonal experiment (16 (4(4))) was investigated to get the best extraction conditions. In this method, the highest yield was obtained when the extraction solvent used ethanol; the ratio of raw material to solvent, the extraction time, the extraction temperature and microwave irradiation power were 1 : 20 (g mL(-1)), 30 min, 55°C and 1.0 kW, respectively. The average yield of trans-resveratrol was 90.87%, and the recovery was in the range of 85.49-89.04% with relative standard deviation lower than 1.39%. Then, the extract of MAE was separated by NKA-9 macroporous resin and re-crystallisation. Finally, the purity of trans-resveratro... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414301 Mon, 14 Nov 2011 05:00:00 +0100 5414301 http://www.medworm.com/index.php?rid=5414300&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22077559%26dopt%3DAbstract Authors: Ferreira S, Santos J, Duarte A, Duarte AP, Queiroz JA, Domingues FC Abstract In this work, the in vitro antimicrobial activity of different crude extracts obtained from Cistus ladanifer L. and Arbutus unedo L. was investigated. The ethanol, methanol and acetone/water extracts of Cistus ladanifer and Arbutus unedo were prepared using different extraction methods and their antimicrobial activities against reference strains, including three Gram-positive, five Gram-negative and three yeasts, and against clinical isolates of Helicobacter pylori and methicillin-resistant Staphylococcus aureus, were investigated. All the extracts inhibited more than one microorganism; moreover all of them presented antimicrobial activity against the Gram-positive bacteria, Klebsiella pneumonia,... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414300 Mon, 14 Nov 2011 05:00:00 +0100 5414300 http://www.medworm.com/index.php?rid=5414299&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22081901%26dopt%3DAbstract In this study, we report the isolation and identification of several compounds from Plantago sempervirens Crantz, collected in the protected area of Majella National Park. We examined the polar fraction, in particular the iridoidic one. Aucubin, caryoptoside, plantarenaloside and gardoside were isolated and identified. For the first time, in this species, 8-epiloganic acid was recognised. Also, verbascoside, a phenylethanoid glycoside, was recognised in this plant. PMID: 22081901 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414299 Mon, 14 Nov 2011 05:00:00 +0100 5414299 http://www.medworm.com/index.php?rid=5414309&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22077157%26dopt%3DAbstract This study demonstrates that the leaves of P. cattleianum possess main compounds with interesting antioxidant and radical-scavenging activities, as clarified by four biological assays. Our findings may justify the use of these leaves in the traditional medicine of French Polynesia. Among the total eight known compounds, reynoutrin and luteolin were isolated for the first time from the genus Psidium. PMID: 22077157 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414309 Fri, 11 Nov 2011 05:00:00 +0100 5414309 http://www.medworm.com/index.php?rid=5414308&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22077203%26dopt%3DAbstract Authors: Zheleva-Dimitrova D, Nedialkov P, Girreser U, Kitanov G Abstract The occurrence of three known benzophenones, namely annulatophenonoside, acetylannulatophenonoside and annulatophenone as well as a flavonol O-glycoside guajaverin in the aerial parts of Hypericum maculatum Crantz was established. In addition, hyperoside, isoquercitrin and miquelianin were isolated from this plant, as well. Radical scavenging and antioxidant activities of the isolated compounds were examined using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) free radicals, ferric reducing antioxidant power (FRAP) assay and inhibition of lipid peroxidation in linoleic acid system by the ferric thiocyanate method. Isoquercitrin demonstra... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414308 Fri, 11 Nov 2011 05:00:00 +0100 5414308 http://www.medworm.com/index.php?rid=5414307&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22077268%26dopt%3DAbstract Authors: Guan L Abstract A native polysaccharide (MCP2) was extracted and isolated from Momordica charantia. Four sulphated derivatives of MCP2 were prepared by chlorosulphonic acid method. The structures of the sulphated derivatives were characterised by FT-IR spectra. Depending on the reaction conditions, the sulphated derivatives showed different degree of substitution (DS) ranging from 0.56 to 1.10, and different weight-average molecular mass (Mw) ranging from 7.2 to 9.3 KDa. It implied the efficient substitution of hydroxyl groups in the polysaccharides by sulphated groups with degradation. The effects of the sulphated derivatives on inhibiting the growth of HepG2 cells and Hela cells in vitro were compared with taking non-modified MCP2 as control. The sulphated derivatives... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414307 Fri, 11 Nov 2011 05:00:00 +0100 5414307 http://www.medworm.com/index.php?rid=5414306&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22077331%26dopt%3DAbstract Authors: Verma RS, Padalia RC, Saikia D, Chanotiya CS, Chauhan A, Krishna B Abstract Essential oil isolated from the inflorescences of Capillipedium parviflorum (R. Br.) Stapf., collected from Kumaon region of Western Himalaya, India, was investigated by GC and GC-MS. A total of 45 constituents representing 99.0% of the essential oil were identified. The major components of this oil were 4-undecanone (33.2%), 4-undecanol (29.7%), 4-nonanol (13.9%), α-muurolol (5.3%), 4-tridecanone (3.6%), methyl-2-oxo-nonanoate (3.1%), trans-2-hexenyl butanoate (1.1%) and 1-tetradecanol (1.0%). The antimicrobial activity of the essential oil was determined against eight Gram-positive and Gram-negative bacterial strains, as well as two fungal strains. The bioassay showed that the essential oil poss... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414306 Fri, 11 Nov 2011 05:00:00 +0100 5414306 http://www.medworm.com/index.php?rid=5414305&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22077382%26dopt%3DAbstract Authors: Kuo SY, Lin RJ, Yeh YT, Lee JY, Chen CY Abstract A new phenylalkanoid, (E)-3-hydroxy-1-(4'-dihydroxy-3',5'-dimethoxy-phenyl)-dodecan-6-en-5-one (1) was isolated from the rhizomes of Chinese ginger (Zingiber officinale Roscoe (Zingiberaceae)). The structure of this new phenylalkanoid was elucidated by chemical and physical evidences. PMID: 22077382 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414305 Fri, 11 Nov 2011 05:00:00 +0100 5414305 http://www.medworm.com/index.php?rid=5414304&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22077392%26dopt%3DAbstract Authors: Song G, Du Q Abstract A water-soluble α β-glucan with a molecular weight of 1.62 × 10(5) Da, AAPS -1, was obtained from the fruiting bodies of the edible mushroom Auricularia polytricha by a combined separation of high-speed countercurrent chromatography (HSCCC)-Sephacryl S-300 HR column chromatography. The structure of AAPS-1 was elucidated that the polysaccharide possesses a backbone composed of (1 → 6)-linked-α-D-glucopyranosyl and (1 → 6)-linked-β-D-glucopyranosyl residues, partially substituted at O-3 of β-D-glucopyranosyl residue by side chain (1 → 4)-α-D-Glcp and terminated with non-reducing end α-D-Glcp-(1 → on the basis of the analyses of partial hydrolysis, periodate oxidation, acetylation, methylation and NMR spectroscopy ((1)... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414304 Fri, 11 Nov 2011 05:00:00 +0100 5414304 http://www.medworm.com/index.php?rid=5414303&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22077422%26dopt%3DAbstract In this study, a headspace solid-phase microextraction (HS-SPME) method, in combination with gas chromatography flame ionisation detector and gas chromatography-mass spectrometry, has been developed for use in the analysis of the volatile compounds of Teucrium flavum L. subsp. flavum, a plant whose particular fragrance is used in the preparation of flavoured wines, bitters and liqueurs, or as a substitute for hops in the flavouring of beer. The tested fibres were 100 µm poly(dimethylsiloxane) (PDMS), the 65 µm PDMS/divinylbenzene (DVB) and 50/30 µm DVB-carboxen-PDMS. The best fibre was found to be PDMS when working in the following conditions: 60°C temperature, 30 min extraction time, 30 mg sample amount, 1 mm sample particle size. The HS-SPME method permitted the identific... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414303 Fri, 11 Nov 2011 05:00:00 +0100 5414303 http://www.medworm.com/index.php?rid=5414302&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22077457%26dopt%3DAbstract Authors: Thuy TT, Quan TD, Anh NT, Van Sung T Abstract Two new aporphine alkaloids: 8-hydroxy-9-methoxy-1,2-methylenedioxyaporphine (1) and 8-hydroxy-3,9-dimethoxy-1,2-methylenedioxyaporphine (2) were isolated from the ethyl acetate extract of Fissistigma poilanei along with five known compounds: oxocrebanine (3), kuafumine (4), (2R,3R)-3',4',5,7-tetrahydroxydihydroflavonol-3-O-α-L-rhamnopyranoside (5), (+)-catechin 3-O-α-L-rhamnopyranoside (6) and quercetine 3,7-dimethoxy-3'-O-α-L-rhamnopyranosyl-(1 → 2)-β-D-glucopyranoside (7). These two new aporphine alkaloids exhibited a moderate cytotoxic activity against four human cancer cell lines (KB, Hep-G2, MCF-7, LU) as well as antimicrobial activity against Lactobacillus fermentum, Enterococcus faecium, Staphylococcus aureus ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414302 Fri, 11 Nov 2011 05:00:00 +0100 5414302 http://www.medworm.com/index.php?rid=5414313&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22053735%26dopt%3DAbstract Authors: Mohammadi M, Ghavidel M, Habibi Z, As'habi MA Abstract The chemical composition of the essential oil of Haussknechtia elymaitica Boiss. was investigated by capillary GC and GC/MS for the first time. Twelve components were identified which accounting for 99.7% of the oil composition. The major compounds were trans-asarone (59.9%), trans-methyl isoeugenol (22.4%), α-zingiberene (7.96%), β-sesquiphellandrene (4.7%) and β-bisabolene (4.3%). The first three compounds considered as the main components of the essential oil were isolated and characterised by spectroscopic techniques. PMID: 22053735 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414313 Mon, 07 Nov 2011 05:00:00 +0100 5414313 http://www.medworm.com/index.php?rid=5414312&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22060136%26dopt%3DAbstract Authors: Kontogianni VG, Gerothanassis IP Abstract The total phenolic content and antioxidant activities of olive leaf extracts were determined. Plant material was extracted with methanol and fractionated with solvents of increasing polarity, giving certain extracts. The qualitative changes in the composition of the extracts were determined after the storage of leaves for 22 h at 37°C, before the extraction. Total polyphenol contents in extracts were determined by the Folin-Ciocalteu procedure. They were also analysed by liquid chromatography-mass spectrometry. Their antioxidant activities were evaluated using the diphenyl picrylhydrazyl method and the β-carotene linoleate model assay. Moreover, the effects of different crude olive leaf extracts on the oxidative stability of su... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414312 Mon, 07 Nov 2011 05:00:00 +0100 5414312 http://www.medworm.com/index.php?rid=5414311&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22060194%26dopt%3DAbstract Authors: Tewari G, Pande C, Kharkwal G, Singh S, Singh C Abstract The essential oil composition of Coleus aromaticus Benth. (family Lamiaceae) was examined by capillary GC and GC-MS. Analyses revealed the presence of 28 constituents, of which 16 were identified. Thymol (83.39%) was found to be the major compound, while 1-octen-3-ol, terpine-4-ol, eugenol, trans-caryophyllene, caryophyllene oxide and α-cadinol were present as minor constituents. PMID: 22060194 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414311 Mon, 07 Nov 2011 05:00:00 +0100 5414311 http://www.medworm.com/index.php?rid=5414310&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22060314%26dopt%3DAbstract Authors: Pant CC, Melkani AB, Mohan L, Dev V Abstract The chemical composition of the steam volatile oil of the whole aerial part of Scutellaria grossa Wall ex Benth. (Lamiaceae), obtained by steam distillation, has been analysed by capillary GC and GC-MS. The oil was found to be rich in oxygenated monoterpenes (88.6%). A total of 50 constituents were identified, representing 94.4% of the total oil composition. Linalool (37.0%) and 1-octen-3-ol (32.0%) were found to be the principal constituents. The antibacterial activity of the oil was determined against 10 bacterial strains by measuring the growth inhibitory zones. The oil showed significant antibacterial activity against Gram-positive bacteria, Bacillus subtilis and Enterococcus faecalis, and the Gram-negative, Klebsiella pneum... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5414310 Mon, 07 Nov 2011 05:00:00 +0100 5414310 http://www.medworm.com/index.php?rid=5377333&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fcmd%3DSearch%26db%3Dpubmed%26term%3D%28%2520%28%2522Nat%2520Prod%2520Res%2522%255Bta%255D%29%2520AND%2520%25222011%252F10%252F07%252023.04%2522%255BEDAT%255D%253A%25222011%252F11%252F05%252007.40%2522%255BEDAT%255D%29 136 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Nat Prod Res"[ta] These pubmed results were generated on 2011/11/05PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5377333 Sat, 05 Nov 2011 11:40:02 +0100 5377333 http://www.medworm.com/index.php?rid=5294306&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21972920%26dopt%3DAbstract In this study, turmerin, a water-soluble peptide in turmeric rhizomes, was evaluated for its inhibitory potential against glucosidase and its antioxidant (AO) capacity. Turmerin inhibited α-amylase and α-glucosidase activities with IC(50) values 31 and 192 µg mL(-1), respectively. Under the experimental conditions, those values for a standard glucosidase inhibitor, acarbose, were 81 and 296 µg mL(-1), respectively. The AO capacity of turmerin was evaluated using in vitro assay systems. Turmerin showed good DPPH (IC(50) = 29 µg mL(-1)) and superoxide (IC(50) = 48 µg mL(-1)) and moderate ABTS (IC(50) = 83 µg mL(-1)) radical scavenging and Fe(II) chelation (IC(50) = 101 µg mL(-1)) capacities. The inhibitory potential showed by turmerin against ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5294306 Thu, 06 Oct 2011 04:00:00 +0100 5294306 http://www.medworm.com/index.php?rid=5294305&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21972976%26dopt%3DAbstract Authors: Huang Z, Yang J, Cai X, She Z, Lin Y Abstract A new furanocoumarin, 5-methyl-8-(3-methylbut-2-enyl) furanocoumarin (1), together with seven known compounds, sterequinone C (2), cyclo(6,7-en-Pro-L-Phe) (3), bergapten, scopoletin, umbelliferone, 1,7-dihydroxyxanthone and 3,5-dimethoxybiphenyl, was isolated from the mangrove endophytic fungus, Penicillium sp. ZH16 obtained from the South China Sea. Their structures were determined by analysis of spectroscopic data. Compound 1 exhibited cytotoxicity against KB and KB(V)200 cells in vitro with IC(50) values 5 and 10 µg mL(-1), respectively. PMID: 21972976 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5294305 Thu, 06 Oct 2011 04:00:00 +0100 5294305 http://www.medworm.com/index.php?rid=5273624&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21958354%26dopt%3DAbstract In this study, it was established for the first time that not only do smoke flavour compounds complex with iron which could potentially retard food spoilage, but also after complexation, some complexes attain antimicrobial activities compared to the inactive free ligands. PMID: 21958354 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5273624 Fri, 30 Sep 2011 04:00:00 +0100 5273624 http://www.medworm.com/index.php?rid=5273623&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21958384%26dopt%3DAbstract Authors: Chen H, Wang Z, Yang L Abstract Euphorbia helioscopia L. has been used as a herbal remedy for cancer in mainland China. Euphornin is one of the main bioactive constituents with the maximal content of Euphorbia helioscopia L. A reversed-phase high-performance liquid chromatography method with evaporative light scattering detection (ELSD) was developed for the analysis of euphornin for better quality control of E. helioscopia L. A good calibration curve in double logarithmic coordinator for euphornin was obtained. The validation study showed high recoveries (>97.0%) and low coefficient of variation (<3.0%). The use of the method on different euphornin extract samples confirmed its effectiveness. It was shown that ELSD was an effective detection method for the analysis ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5273623 Fri, 30 Sep 2011 04:00:00 +0100 5273623 http://www.medworm.com/index.php?rid=5273628&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21950559%26dopt%3DAbstract Authors: Ali SA, Meitei KV Abstract The effects of the root extract of Withania somnifera and its active ingredient Withaferin A on the isolated melanophores of the wall lizard H. flaviviridis were studied in order to establish the mechanism of skin darkening at the cellular level. Significant skin darkening activity of the extract of W. somnifera and Withaferin A was observed on the isolated melanophores of the wall lizard. The melanin dispersal effects leading to the darkening of the skin were antagonised by atropine and hyoscine, and were also found to be highly potentiated by neostigmine. These findings suggest that the extract of W. somnifera, as well as its active principle, mimic the action of acetylcholine in melanin dispersion, thus leading to skin darkening via stimulatio... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5273628 Tue, 27 Sep 2011 04:00:00 +0100 5273628 http://www.medworm.com/index.php?rid=5273627&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21950614%26dopt%3DAbstract This study was conducted to analyse the free radical scavenging potential of callus obtained from nodal segments and leaf explants of Artemisia amygdalina Decne. The explants were inoculated on MS medium augmented with various concentrations of BAP, Kn, NAA and 2,4-D for callus induction. In this study, 12.42 g of callus developed from the leaf explant on MS (NAA 10 + BAP 7.5 µM) and 8.81 g of callus developed from nodal explant on NAA 2 µM+BAP 2 µM. Callus raised from both explants on all treatments seemed non-regenerative but BAP 2 µM produced 7.33 shoots and BAP 15 µM produced callus and 5 shoots per nodal segment. Callus was analysed for antioxidant activity via DPPH, riboflavin photoxidation and DNA damage assays. Methanol and aqueous extracts show more scavengi... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5273627 Tue, 27 Sep 2011 04:00:00 +0100 5273627 http://www.medworm.com/index.php?rid=5273626&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21950651%26dopt%3DAbstract Authors: Shaikh MM, Kruger HG, Bodenstein J, Smith P, du Toit K Abstract Four homoisoflavanones of the 3-benzylidene-4-chromanone type, some of which were previously isolated from Caesalpinia pulcherrima, were synthesised to determine their anti-inflammatory activity and cytotoxicity. A range of four different homoisoflavanones (compounds 4a-4d) were synthesised from the corresponding substituted phenols.(1)H- and (13)C-NMR data together with high-resolution mass spectroscopy data were employed to elucidate the structures. Anti-inflammatory activity was determined in mice with acute croton oil-induced auricular dermatitis. In vitro cytotoxicity was tested against a Chinese hamster ovarian cell line using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assay. ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5273626 Tue, 27 Sep 2011 04:00:00 +0100 5273626 http://www.medworm.com/index.php?rid=5273625&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21950685%26dopt%3DAbstract In conclusion, the inhibition of eugenol on glucan is essential for the biofilm inhibition effect on caries-related biofilm in an artificial mouth model in vitro. PMID: 21950685 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5273625 Tue, 27 Sep 2011 04:00:00 +0100 5273625 http://www.medworm.com/index.php?rid=5273629&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21942471%26dopt%3DAbstract Authors: Huang XZ, Cheng CM, Dai Y, Fu GM, Guo JM, Liang H, Wang C Abstract A novel lignan glysocide, namely sagitiside A (1), together with two known ones, (+)-lyoniresinol-2α-O-β-D-glucopyranoside (2) and (+)-5'-methoxyisolariciresinol 3α-O-β-D-glucopyranoside (3), was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis. The structure of the new compound (1) was determined based on MS, 1D and 2D NMR spectral data. Compounds 1-3 showed antioxidant activity with EC(50) values 55, 75 and 80 µM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay. PMID: 21942471 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5273629 Mon, 26 Sep 2011 04:00:00 +0100 5273629 http://www.medworm.com/index.php?rid=5273631&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21939370%26dopt%3DAbstract Authors: Rajamma AJ, Dubey S, Sateesha SB, Tiwari SN, Ghosh SK Abstract Ocimum is a genus of aromatic herbs, undershurbs or shrubs distributed in the tropical and warm temperate regions of the world. Larvicidal activity of essential oils and different extracts of O. sanctum, O. basilicum and O. gratissimum were compared on laboratory reared and field collected larvae of Culex quinquefasciatus. Thin layer chromatographic analysis revealed that all the three species have similar components and results showed the presence of steroids and triterpenoids. The larvicidal activity was determined in terms of LD(50) value on late third or early fourth instar larvae for a period of 24 h. A comparison of LD(50) value has shown that O. basilicum is more active than the other two species. The ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5273631 Thu, 22 Sep 2011 04:00:00 +0100 5273631 http://www.medworm.com/index.php?rid=5273630&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21939371%26dopt%3DAbstract This study examines the chemical composition and in vitro anticancer activity of the essential oil from Ocimum basilicum Linn. (Lamiaceae), cultivated in the Western Ghats of South India. The chemical compositions of basil fresh leaves were identified by GC-MS: 11 components were identified. The major constituents were found to be methyl cinnamate (70.1%), linalool (17.5%), β-elemene (2.6%) and camphor (1.52%). The results revealed that this plant may belong to the methyl cinnamate and linalool chemotype. A methyl thiazol tetrazolium assay was used for in vitro cytotoxicity screening against the human cervical cancer cell line (HeLa), human laryngeal epithelial carcinoma cell line (HEp-2) and NIH 3T3 mouse embryonic fibroblasts. The IC(50) values obtained were 90.5 and 96.3 µg mL(-... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5273630 Thu, 22 Sep 2011 04:00:00 +0100 5273630 http://www.medworm.com/index.php?rid=5273653&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21936638%26dopt%3DAbstract Authors: Yao Y, Cai W, Yang C, Hua H Abstract Contact toxicities of Acorus calamus L. (Arales: Araceae) extracts obtained from four published extraction methods: soakage, soxhlet, ultrasonic and supercritical fluid CO(2) (SFE-CO(2)), were compared in this study. Under the given extraction conditions, SFE-CO(2) extract exhibited the highest contact toxicity against S. zeamais of the four methods. With the SFE-CO(2) method, extraction temperature, pressure, time and the amount of EtOH (the extraction solvent) were identified as having a significant effect on the extract. Orthogonal experiments showed that the optimal extraction parameters were: temperature - 55°C, pressure - 35 MPa, time - 40 min and EtOH - 150 mL per 200 g of dry powder. Under these conditions, the yield wa... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5273653 Wed, 21 Sep 2011 04:00:00 +0100 5273653 http://www.medworm.com/index.php?rid=5273652&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21936639%26dopt%3DAbstract Authors: Jaramillo-Colorado B, Olivero-Verbel J, Stashenko EE, Wagner-Döbler I, Kunze B Abstract Essential oils from Colombian plants were characterised by GC-MS, and assayed for anti-quorum sensing activity in bacteria sensor strains. Two major chemotypes were found for Lippia alba, the limonene-carvone and the citral (geranial-neral). For other species, the main components included α-pinene (Ocotea sp.), β-pinene (Swinglea glutinosa), cineol (Elettaria cardamomun), α-zingiberene (Zingiber officinale) and pulegone (Minthostachys mollis). Several essential oils presented promising inhibitory properties for the short chain AHL quorum sensing (QS) system, in Escherichia coli containing the biosensor plasmid pJBA132, in particular Lippia alba. Moderate activity as anti-QS using th... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5273652 Wed, 21 Sep 2011 04:00:00 +0100 5273652 http://www.medworm.com/index.php?rid=5273651&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21936641%26dopt%3DAbstract Authors: Mohammed MM, Ibrahim NA, Awad NE, Matloub AA, Mohamed-Ali AG, Barakat EE, Mohamed AE, Colla PL Abstract Erythrina abyssinica Lam. is an important medicinal plant growing in Sudan; its seeds were investigated for the first time for their alkaloidal constituents and biological activity. The in vitro cytotoxicity of the crude alkaloidal fraction (CAF) against the cell lines HeLa, Hep-G2, HEP-2, HCT116, MCF-7 and HFB4 showed promising activity, with IC(50) values of 13.8, 10.1, 8.16, 13.9, 11.4 and 12.2 µg mL(-1), respectively. Doxorubicin (positive control) showed in vitro cytotoxic activity with IC(50) values 3.64, 4.57, 4.89, 3.74, 2.97 and 3.96 µg mL(-1), respectively. Bioassay-guided fractionation and isolation of the CAF led to the isolation of five Erythrina... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5273651 Wed, 21 Sep 2011 04:00:00 +0100 5273651 http://www.medworm.com/index.php?rid=5273650&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21936665%26dopt%3DAbstract Authors: de Araújo MF, Curcino Vieira IJ, Braz-Filho R, de Carvalho MG Abstract The first phytochemical study of Simira eliezeriana Peixoto (Rubiaceae) allowed the isolation and structural determination of two new diterpenes named simirane A [(5R,6R,8R,9R,10S,11S,13S)-6β,11β-dihydroxy-2,4(18),15-erythroxylatrien-1-one] (1) and simirane B [(5S,8R,9R,10S,11S,13S)-11β-hydroxy-2,4(18),15-erythroxylatrien-1-one] (2), together with seven known compounds: sitosterol (3), stigmasterol (4), campesterol (5), coniferaldehyde (6), vanillin (7), pinoresinol (8) and harman (9) from the bark of the plant. The structures of the compounds were established on the basis of spectroscopic methods, including 1-D and 2-D NMR, HRESI-MS and CD analysis and comparisons with available literature data of ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5273650 Wed, 21 Sep 2011 04:00:00 +0100 5273650 http://www.medworm.com/index.php?rid=5241410&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21923558%26dopt%3DAbstract Authors: Yang DJ, Yu ZS, Ma RJ, Guo SJ, Ding L Abstract A new ent-kaurane diterpenoid, Pseurata H (1), was isolated from the aerial parts of Rabdosia pseudo-irrorata C. Y. Wu, along with three known compounds, Pseurata B (2), Pseurata C (3) and Pseurata F (4). Their structures were established by extensive spectroscopic techniques (MS, IR, 1D and 2D NMR experiments). PMID: 21923558 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5241410 Mon, 19 Sep 2011 04:00:00 +0100 5241410 http://www.medworm.com/index.php?rid=5241409&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21923560%26dopt%3DAbstract Authors: Fan P, Zhao L, Hostettmann K, Lou H Abstract A phytochemical study of Asplenium ruta-muraria L. (Aspleniaceae) led to the isolation of a new caffeic acid glycoside, 2-O-caffeoyl-β-D-fructofuranosyl-(2 → 1)-α-D-glucopyranoside and an (α, β)-isomeric pair of 2E-caffeoyl-D-glucopyranoside, together with kaempferol-3-O-β-D-[6-E-caffeoyl-β-D-glucopyranosyl-(1 → 2)glucopyranoside]-7-O-β-D-glucopyranoside, 1-O-caffeoyl glycoside, sucrose, diploptene and β-sitosterol. Their structures were established by means of MS and capillary NMR techniques. Additionally, aromatase inhibitory activity of the extracts and phenolic compounds was evaluated. PMID: 21923560 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5241409 Mon, 19 Sep 2011 04:00:00 +0100 5241409 http://www.medworm.com/index.php?rid=5241408&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21923561%26dopt%3DAbstract Authors: Jayasinghe L, Amarasinghe NR, Arundathie BG, Rupasinghe GK, Jayatilake NH, Fujimoto Y Abstract Chemical investigation of the leaves of Elaeocarpus serratus yielded myricitrin (1), mearnsetin 3-O-β-D-glucopyranoside (2), mearnsitrin (3), tamarixetin 3-O-α-L-rhamnopyranoside (4) and the fruits of Filicium decipiens yielded three flavonol glycosides, kaempferol 3-O-rutinoside (5), kaempferol 3-O-robinobioside (6) and trifolin (7). Compound 1 showed strong antioxidant activity against DPPH. PMID: 21923561 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5241408 Mon, 19 Sep 2011 04:00:00 +0100 5241408 http://www.medworm.com/index.php?rid=5241407&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21923622%26dopt%3DAbstract Authors: Maity N, Nema NK, Sellamuthu MK, Sarkar BK, Mukherjee PK Abstract A RP-HPLC method was developed (λ (max) = 280) to quantify hydroxychavicol and chlorogenic acid in Piper betel Linn. The method was validated for linearity, limit of detection (LOD = 3:1σ/S), limit of quantification (LOQ = 10:1σ/S), precision, accuracy and ruggedness. The response was linear with good correlation between concentration and mean peak area through a coefficient of determinants (r (2)) of 0.9940, y = 1.98e + 004x + 5.19e + 004 and 0.9945, y = 2.76e + 004x + 1.40e + 005 with LOD 1.6 µg mL(-1), 1.0 µg mL(-1) and LOQ 5.0 µg mL(-1) and 3.0 µg mL(-1), respectively, for hydroxychavicol (28.56% w/w) and chlorogenic acid (0.40% w/w). The... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5241407 Mon, 19 Sep 2011 04:00:00 +0100 5241407 http://www.medworm.com/index.php?rid=5241406&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21923624%26dopt%3DAbstract Authors: Hoskeri HJ, Krishna V, Babu PS Abstract The antinociceptive activity of Flaveria trinervia extracts by tail-flicking and writhing methods was evaluated using mice. The abdominal writhing method was carried out by administering petroleum ether, chloroform and methanol extracts orally. After 1 h of incubation, 0.6% acetic acid (10 mL kg(-1)) was administered intraperitoneally. After 5 min, each group of mice was observed for the amount of writhing for a duration of 20 min. Acetyl salicylic acid was used as the standard reference. The tail-flick method was carried out using a thermal model and the maximum possible analgesia was calculated. The LD(50) values of petroleum ether, chloroform and methanol extracts were 700, 700 and 500 mg kg(-1), respectively. The me... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5241406 Mon, 19 Sep 2011 04:00:00 +0100 5241406 http://www.medworm.com/index.php?rid=5241405&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21923631%26dopt%3DAbstract Authors: Li XN, Chen YY, Cheng DP, Tong SQ, Qu HB, Yan JZ Abstract The phytochemical investigation of extracts from the radix of Angelica sinensis yielded a new phthalide dimer, 3,3'Z-6.7',7.6'-diligustilide (1), along with a known dimer, levistolide A (2). Their structures were established on the basis of spectral data, particularly using 1D-NMR and several 2D shift-correlated NMR pulse sequences ((1)H-(1)H COSY, HSQC, HMBC and NOESY). PMID: 21923631 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5241405 Mon, 19 Sep 2011 04:00:00 +0100 5241405 http://www.medworm.com/index.php?rid=5241404&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21929280%26dopt%3DAbstract This study concludes that residues of the volatile extract of Q. leucotrichophora could serve as an important bioresource for the extraction and isolation of monoterpenoids exhibiting antimicrobial activity, and thus has good potential for use in the pharmaceutical industry. PMID: 21929280 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5241404 Mon, 19 Sep 2011 04:00:00 +0100 5241404 http://www.medworm.com/index.php?rid=5241403&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21929282%26dopt%3DAbstract Authors: Ragasa CY, Espineli DL, Shen CC Abstract The freeze-dried bark of Barringtonia asiatica afforded a new triterpene: (3β,11α)-11-hydroxyolean-12-en-3-yl palmitate (1). The bark also yielded mixtures of (3β)-olean-12-en-3-yl palmitate (2a), (3β)-urs-12-en-3-yl palmitate (2b) and (3β)-olean-18-en-3-yl palmitate (2c) in a 2 : 1 : 4 ratio; β-amyrin (3a), α-amyrin (3b) and germanicol (3c) in a 3 : 1 : 4 ratio; 22-O-tigloylcamelliagenin A (4a) and betulinic acid (4b) in a 2 : 1 ratio; olean-12-en-3β,16β,22α-triol (5), β-sitosterol, spinasterol, squalene and trilinolein. The roots yielded 2a-c and 3a-c as well as trilinolein, spinasterol and squalene, while the flowers afforded verimol k (6), linoleic acid, spinasterol, squalene, phytyl fatty acid est... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5241403 Mon, 19 Sep 2011 04:00:00 +0100 5241403 http://www.medworm.com/index.php?rid=5225853&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21916769%26dopt%3DAbstract Authors: Khajeh M, Ghanbari A Abstract Essential oil of Salvia mirzayanii cultivated in Iran was obtained by microwave assisted extraction (MAE) procedures. The essential oil was analysed by capillary gas chromatography using flame ionisation and mass spectrometric detections. The effects of different parameters, such as microwave power, temperature, time and type of solvent on the MAE of Salvia mirzayanii oil were investigated. Results of the two-level fractional factorial design (2(4?1)) based on an analysis of variance demonstrated that only the power, temperature and type of solvent were statistically significant. Optimal conditions for the extraction of essential oils were obtained by using Box?Behnken design. For optimum recovery of essential oil the variables power, temperat... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5225853 Thu, 15 Sep 2011 04:00:00 +0100 5225853 http://www.medworm.com/index.php?rid=5225852&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21916770%26dopt%3DAbstract Authors: Ilavarasan R, Mohideen S, Venkataraman S Abstract Analgesic and anti-inflammatory activities of the aqueous and ethanol extracts of Thespesia populnea Soland. ex. Correa (Malvaceae) leaves were evaluated in animal models. Orally-administered aqueous and ethanol extracts (100, 200 and 400?mg?kg(?1) bw) showed significant analgesic activity in chemical-, mechanical- and thermally-induced pain test models in mice. The extracts also reduced paw oedema induced by carrageenan in rats. The results obtained in this study suggest that Thespesia populnea extracts have analgesic and anti-inflammatory properties. PMID: 21916770 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5225852 Thu, 15 Sep 2011 04:00:00 +0100 5225852 http://www.medworm.com/index.php?rid=5225851&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21916771%26dopt%3DAbstract Authors: Tan QW, Ouyang MA, Wu ZJ Abstract A new seco-neolignan glycoside, seco-dehydrodiconiferyl alcohol-4-O-?-D-glucopyranoside (1), together with eight known compounds, were obtained from the EtOH extract of the root bark of Ailanthus altissima. Their structures were elucidated based on the spectroscopic data. Three neolignan glycosides including 7,9,9?-trihydroxy-3,3?,5?-trimethoxy-8-O-4?-neolignan-4-O-?-D-glucopyranoside (5), sonchifolignan B (6) and citrusin B (7) exhibited moderate in?vitro inhibitory effect on tobacco mosaic virus replication with IC(50) values 0.30, 0.35 and 0.26?mmol?L(?1), respectively. PMID: 21916771 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5225851 Thu, 15 Sep 2011 04:00:00 +0100 5225851 http://www.medworm.com/index.php?rid=5225850&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21916772%26dopt%3DAbstract Authors: Tan QW, Ouyang MA, Shen S, Li W Abstract Two new compounds named fischeacid (1) and fischexanthone (2), together with eight known compounds, were obtained from the culture of a marine-derived fungus Neosartorya fischeri strain 1008F(1). The structures of the new compounds were elucidated based on the spectroscopic data. Bioassays indicated that AGI-B4 (5) and 3,4-dihydroxybenzoic acid (10) showed potent inhibitory effect on the replication of tobacco mosaic virus, and AGI-B4 also possessed an inhibition of the cell proliferation of human gastric cancer cell line SGC-7901 and hepatic cancer cells BEL-7404. PMID: 21916772 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5225850 Thu, 15 Sep 2011 04:00:00 +0100 5225850 http://www.medworm.com/index.php?rid=5225849&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21919561%26dopt%3DAbstract Authors: El-Askary HI, El-Olemy MM, Salama MM, Sleem AA, Amer MH Abstract Ethanolic and aqueous extracts of the leaves and flowers of Alstonia scholaris were evaluated for their antioxidant activity by investigating their effect on blood glutathione levels in alloxan-induced diabetic rats. The ethanolic extract of the leaves was the most active; therefore, its cytotoxicity against HepG2 cells was also tested. Promising GI(50) values of 1.96, 4.34 and 4.65??g?mL(?1) were observed for the extract, its chloroform and ethyl acetate fractions, respectively. The chloroform active subfraction I (GI(50)?=?2.97??g?mL(?1)) yielded betulin (1), betulinic acid (2) and ursolic acid (3) upon purification. Compounds 1?3 were identified using spectroscopic techniques and by comparison with reporte... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5225849 Thu, 15 Sep 2011 04:00:00 +0100 5225849 http://www.medworm.com/index.php?rid=5215845&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21902562%26dopt%3DAbstract Authors: Wang Z, Liu Z, Cao Z, Li L Abstract Garlic (Allium sativum L.; Liliaceae) has been widely demonstrated in the role of cancer prevention, but the specific compound in garlic corresponding to this effect and its mechanisms are not clearly known. Allicin is one of the organic sulphur compounds derived from garlic. In the present study we investigated the anti-proliferative and pro-apoptotic activities of allicin in murine T-lymphocytes (EL-4) and the mechanism of inducing apoptosis in vitro. The results showed that allicin was effective in inhibiting the proliferation of EL-4 cells in vitro in a concentration-dependent manner. Further, allicin could induce the formation of apoptotic bodies, nuclear condensation, DNA spallation, and even activated the expression of caspase-3... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215845 Fri, 09 Sep 2011 04:00:00 +0100 5215845 http://www.medworm.com/index.php?rid=5215844&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21902563%26dopt%3DAbstract Authors: Marongiu B, Piras A, Porcedda S, Falconieri D, Frau MA, Maxia A, Gonçalves MJ, Cavaleiro C, Salgueiro L Abstract The essential oils and supercritical CO(2) extracts of wild Smyrnium olusatrum L. growing in Sardinia (Italy) and in Portugal were investigated. For the study, oils were isolated from total plant aerial part (umbels containing seeds). The content of β-phellandrene (67.3% vs. 42.7%) and α-pinene (31.9% vs. 1.2%), respectively, the main components of Portuguese and Italian essential oils, declined during the maturation stage of the umbels. Contrarily, some other important components, particularly curzerene, germacrene B, germacrone, alexandrofuran, 1-β-acetoxyfurano-4(15)-eudesmene and 1-β-acetoxyfurano-3-eudesmene, increased in fruiting umbels. The chemical ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215844 Fri, 09 Sep 2011 04:00:00 +0100 5215844 http://www.medworm.com/index.php?rid=5215843&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21902569%26dopt%3DAbstract Authors: Kahriman N, Tosun G, Iskender NY, Karaoğlu SA, Yayli N Abstract The essential oils of Centaurea pulcherrima Willd. var. pulcherrima (Asteraceae) were isolated by hydrodistillation (HD) and a microwave distillation (MD), than characterised by GC-FID and GC-MS. A total of 58 and 57 compounds were identified, constituting over 93.7%, and 91.6% of volatile oil composition of C. pulcherrima var. pulcherrima, respectively. Sesquiterpene hydrocarbons were shown to be the main group of constituents (HD: 42.4% versus MD: 51.5%). The major component of the oils of C. pulcherrima var. pulcherrima was germacrene D (HD, 17.8% versus MD, 23.2%). The antimicrobial activity of the isolated essential oils of the plant was also investigated, and they showed good antibacterial activity agai... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215843 Fri, 09 Sep 2011 04:00:00 +0100 5215843 http://www.medworm.com/index.php?rid=5215849&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21899477%26dopt%3DAbstract Authors: Yang NY, Liu L, Tao WW, Duan JA, Liu XH, Huang SP Abstract Chemical investigation of Semen Persicae has led to the isolation of decane (1), triolein (2), nonacosanoic acid (3), oleic acid ethyl ester (4), palmitic acid (5), oleic acid (6) and 15,16-dihydroxy-9Z,12Z-octadecadienoic acid 2,3-dihydroxypropyl ester (7). Amongst these, compound 7 is a new lipid. Their structures were elucidated by chemical and extensive spectral analysis. Their anticoagulative activities were also evaluated in vitro, which showed that petroleum ether extract and compounds 5-6 could significantly prolong thrombin time while methanol extract could obviously inhibit platelet aggregation. PMID: 21899477 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215849 Thu, 08 Sep 2011 04:00:00 +0100 5215849 http://www.medworm.com/index.php?rid=5215848&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21899480%26dopt%3DAbstract Authors: Kamble S, Gopalakrishnan R, Eapen S Abstract Camptothecin (CPT), the derivatives of which are used clinically for the treatment of metastatic colon cancer, is isolated from intact plants that can be subjected to environmental fluctuations. In vitro cultures may be an alternate and continuous source for year-round production of CPT. Since CPT production by undifferentiated cell cultures is low, differentiated tissues such as root cultures may be a viable alternate source for CPT production. Hairy roots were induced in Ophiorriza rugosa, a source of CPT, using Agrobacterium rhizogenes strain LBA9402. The hairy roots, when cultured in light, showed spontaneous regeneration of shoots. Analysis of CPT levels in the hairy roots and in vitro-grown transformed shoots revealed 0.... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215848 Thu, 08 Sep 2011 04:00:00 +0100 5215848 http://www.medworm.com/index.php?rid=5215847&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21899481%26dopt%3DAbstract Authors: Wang JD, Jiang N, Zhang H, Ying LP, Wang CX, Xiang WS, Wu B, Wang HB, Bai H Abstract As a continuous work to find more epothilone congeners produced by the epothilones A and B producing Sorangium cellulosum strain So0157-2 in the large-scale fermentation (5000 L), we reinvestigated the chemical compositions of the fermentation broth. Consequently, two new epothilone variants (1-2) and one new natural epothilone derivative (3) were isolated from the fermentation broth. Their structures were established as 16-ethyl epothilone B (1), 6-desmethyl-16-hydroxymethyl epothilone C (2) and 20-ethyl epothilone A (3), respectively, by an extensive NMR analysis. PMID: 21899481 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215847 Thu, 08 Sep 2011 04:00:00 +0100 5215847 http://www.medworm.com/index.php?rid=5215846&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21899482%26dopt%3DAbstract Authors: Khan NA Abstract Two novel triterpenoid glycosides have been isolated from butanolic seeds extract of two varieties of Lathyrus plants, i.e. Lathyrus ratan and Lathyrus aphaca. Their structures were elucidated as 3-O-[β-D-glucuronopyranosyl-(1 → 4)-α-L-arabinopyranosyl-(1 → 2)-α-L-arabinopyranosyl]-olean-11,13(18)-dien-28-oic acid (1) and 3-O-{β-D-xylopyranosyl-(1  →  2)-β-D-glcopyranosyl-(1 → 4)-[β-D-glucopyranosyl-(1 → 2)]-β-D-xylopyranosyl}-2,16α-dihydroxy-4-hydroxymethyl urs-12-en-28-oic acid (2) on the basis of spectral evidences, i.e. FTIR, (1)H-NMR, (13)C-NMR, ESI-MS and FAB-MS data. The isolated saponins were tested for their antifungal activity. Compound 1 showed maximum inhibition against Colletotrichum dematium (77.8%), ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215846 Thu, 08 Sep 2011 04:00:00 +0100 5215846 http://www.medworm.com/index.php?rid=5215856&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21895454%26dopt%3DAbstract In this study, the cytotoxic effects of this algae on brine shrimp larvae were evaluated and the main sterols of the algae identified. Separation and purification of the compounds was carried out using silica gel column chromatography and HPLC to obtain eight pure compounds, 1-8. Structural elucidation of the constituents was based on the data obtained from (1)H-NMR, (13)C-NMR, HSQC, HMBC, DEPT and EI-MS. The compounds separated from S. oligocystum were identified as 22-dehydrocholesterol (1), cholesterol (2), fucosterol (3), 29-hydroperoxystigmasta-5,24(28)-dien-3β-ol (4), 24-hydroperoxy-24-vinylcholesterol (5), a mixture of 24(S)-hydroxy-24-vinylcholesterol (6) and 24(R)-hydroxy-24-vinylcholesterol (7), and ostreasterol (8) based on their spectral data and from comparison with those pre... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215856 Tue, 06 Sep 2011 04:00:00 +0100 5215856 http://www.medworm.com/index.php?rid=5215855&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21895455%26dopt%3DAbstract Authors: Mani L, Petek S, Valentin A, Chevalley S, Folcher E, Aalbersberg W, Debitus C Abstract The compound haliclonacyclamine A was isolated from the Haliclona sponge at Solomon Islands. It acts as a powerful in vitro and in vivo anti-plasmodial agent against the chloroquine-resistant Plasmodium falciparum strain FCB1and Plasmodium vinckei petteri-infected mice, respectively. PMID: 21895455 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215855 Tue, 06 Sep 2011 04:00:00 +0100 5215855 http://www.medworm.com/index.php?rid=5215854&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21895456%26dopt%3DAbstract Authors: Miladi S, Abid N, Debarnôt C, Damak M, Canard B, Aouni M, Selmi B Abstract The antiviral activities of extracts from Daucus maritimus seeds were investigated against the reverse transcriptase of human immunodeficiency virus (HIV) type 1 and a panel of RNA-dependent RNA polymerases of dengue virus, West Nile virus (WNV) and hepatitis C virus (HCV). The extracts showed moderate to potent inhibition rates against the four viral polymerases. The ethyl acetate extract exhibited a potent inhibitory effect against WNV's RdRp, with an IC(50) value of 8 µg mL(-1). The F (2) fraction exhibited potent inhibitory activity against WNV and HCV's RdRps, with IC(50) values 1 and 5 µg mL(-1), respectively. The P (2) fraction also showed potent inhibitory effects on WNV and HCV's... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215854 Tue, 06 Sep 2011 04:00:00 +0100 5215854 http://www.medworm.com/index.php?rid=5215853&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21895457%26dopt%3DAbstract Authors: Sakunphueak A, Panichayupakaranant P Abstract Lawsone (1), lawsone methyl ether (2), and methylene-3,3'-bilawsone (3) are the main naphthoquinones in the leaf extracts of Impatiens balsamina L. (Balsaminaceae). Antimicrobial activities of these three naphthoquinones against dermatophyte fungi, yeast, aerobic bacteria and facultative anaerobic and anaerobic bacteria were evaluated by determination of minimal inhibitory concentrations (MICs) and minimal bactericidal or fungicidal concentrations (MBCs or MFCs) using a modified agar dilution method. Compound 2 showed the highest antimicrobial activity. It showed antifungal activity against dermatophyte fungi and Candida albicans with the MICs and MFCs in the ranges of 3.9-23.4 and 7.8-23.4 µg mL(-1), respectively, and als... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215853 Tue, 06 Sep 2011 04:00:00 +0100 5215853 http://www.medworm.com/index.php?rid=5215852&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21895461%26dopt%3DAbstract We describe herein a new method used to prepare genipin blue, water-soluble blue pigments, through the reaction of hen egg protein with genipin. The effects of reaction time, reaction temperature, the pH value of the solution and the mass ratio of the reactants on the preparation are studied. One part of genipin reacted with eight parts of hen egg protein (w/w) in water (pH value of reaction system 7.5) at 60°C for 96 h and gave blue pigments with the maximum colour value of 146.2. The blue pigments showed identical absorption activity in UV spectroscopy (λ (max )= 584 nm) to that of gardenia blue pigments, which were prepared from the reaction of genipin with amino acid. PMID: 21895461 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215852 Tue, 06 Sep 2011 04:00:00 +0100 5215852 http://www.medworm.com/index.php?rid=5215851&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21895463%26dopt%3DAbstract Authors: Tan JJ, Tan JM, Tan CH, Qu SJ, Zhu DY Abstract Lamiolactone (1), a new iridoid lactone, together with five known iridoids, were isolated from the 95% EtOH extract of the roots of Lamiophlomis rotata. The structure of 1 was elucidated to be methyl antirrhinolide-4-carboxylate on the basis of spectroscopic analysis. PMID: 21895463 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215851 Tue, 06 Sep 2011 04:00:00 +0100 5215851 http://www.medworm.com/index.php?rid=5215850&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21895464%26dopt%3DAbstract Authors: Pejin B, Bianco A, Newmaster S, Sabovljevic M, Vujisic L, Tesevic V, Vajs V, De Rosa S Abstract The chemical composition of Rhodobryum ontariense (Kindb.) Kindb. has not been previously investigated. Fatty acids of this moss were analysed qualitatively and quantitatively with an aim to identify its corresponding pattern. A total of eight fatty acids were identified including two acetylenic ones: 9,12,15-octadecatrien-6-ynoic acid (42.26%), α-linolenic acid (20.32%), palmitic acid (14.31%), 9,12-octadecadienoic-6-ynoic acid (13.31%), linoleic acid (5.25%), oleic acid (2.47%), stearic acid (1.14%) and γ-linolenic acid (0.92%). To our knowledge, this is the first record of acetylenic fatty acids in the genus Rhodobryum. In general, acetylenic fatty acids vary considerably a... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215850 Tue, 06 Sep 2011 04:00:00 +0100 5215850 http://www.medworm.com/index.php?rid=5215861&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21878001%26dopt%3DAbstract Authors: Chu SS, Liu QR, Jiang GH, Liu ZL Abstract The essential oil of the aerial parts of Amethystea caerulea L. was obtained from steam distillation and investigated by GC and GC-MS. The main components of the essential oil were morrilol (25.1%), 4-vinylguaiacol (14.3%) and acetoanisole (14.3%), followed by linalool (6.6%), eugenol (5.8%) and α-caryophyllene (5.2%). The essential oil showed pronounced contact toxicity against Drosophila melanogaster L. and maize weevil, Sitophilus zeamais (Motsch.), with LD(50) values of 5.18 and 50.45 µg per adult, respectively. The essential oil also possessed strong fumigant toxicity against the maize weevils with an LC(50) value of 25.39 µg mL(-1). PMID: 21878001 [PubMed - as supplied by publisher] (Source: Natural Product Resea... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215861 Wed, 31 Aug 2011 04:00:00 +0100 5215861 http://www.medworm.com/index.php?rid=5215860&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21878003%26dopt%3DAbstract Authors: Zhou M, Zhu H, Wang K, Wei W, Zhang Y Abstract A securinega-type alkaloid epibubbialine was isolated from Phyllanthus niruri Linn. Its structure was established by spectroscopic methods and X-ray single-crystal diffraction analysis. Its crystal structure is reported herein for the first time. PMID: 21878003 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215860 Wed, 31 Aug 2011 04:00:00 +0100 5215860 http://www.medworm.com/index.php?rid=5215859&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21878004%26dopt%3DAbstract Authors: Movafeghi A, Delazar A, Amini M, Asnaashari S Abstract Composition of volatile organic compounds (VOCs) in flowers of Astragalus lagopoides was studied using a hydrodistillation extraction procedure coupled with gas chromatography-mass spectrometry. The analyses allowed the identification of a number of 25 compounds, among which the presence of several bioactive aromatic derivatives such as guaiacol, eugenol, linalool, α- and 4-terpineol as well as nerol was attention-grabbing. Moreover, some other compounds like cyclohexane, 2-bromoethyl with repellent function also appeared to be present in the flower. As a result, the floral VOCs profile of A. lagopoides might reflect an adaptation to attract specialised pollinator insects. These findings provide important information ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215859 Wed, 31 Aug 2011 04:00:00 +0100 5215859 http://www.medworm.com/index.php?rid=5215858&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21878005%26dopt%3DAbstract In this study, we investigated the effects of Danggui Buxue Tang (DBT), a Chinese herbal decoction prepared from Radix Astragali (RA) and Radix Angelicae sinensis (RAS), on high glucose-induced proliferation and expression of laminin, type IV collagen (collagen IV) and fibronectin in glomerular mesangial cells (GMCs). The cell proliferation was determined by MTT assay, and the expression of collagen IV, laminin and fibronectin in GMCs was detected by ELISA assay. It was shown that high glucose clearly induced the proliferation of GMCs and increased the release of collagen IV, laminin and fibronectin. Treatment with RA, RAS and DBT inhibited cell proliferation and the expression of collagen IV, laminin and fibronectin induced by high glucose, with DBT, especially at the highest concentratio... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215858 Wed, 31 Aug 2011 04:00:00 +0100 5215858 http://www.medworm.com/index.php?rid=5215857&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21878033%26dopt%3DAbstract This study investigated the antibacterial activity of these plants against six species of foodborne pathogen. Methods and solvents employed to extract active constituents were optimised using the disc diffusion assay. Phytochemical analysis of the optimised extracts was performed by thin layer chromatography (TLC). Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) were determined by broth microdilution. A. pavonina contained flavonoids, terpines and tannins, and was the most active extract against Campylobacter jejuni, inhibiting growth at 62.5-125 µg mL(-1). The A. squamosa extract contained flavonoids, terpines, tannins and alkaloids, and had the broadest spectrum of antibacterial activity, inhibiting Bacillus cereus, Listeria monocytogenes, Sta... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215857 Wed, 31 Aug 2011 04:00:00 +0100 5215857 http://www.medworm.com/index.php?rid=5215864&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21870933%26dopt%3DAbstract In this study, the total saturated fatty acids ranged between 15.02 and 65.20%, while total monounsaturated fatty acids were between 18.10 and 70.65%. The total polyunsaturated fatty acid accounted for 13.47-35.20% of the studied fatty acids. Therefore, we can conclude that Bupleurum oils have a significant nutritional value. PMID: 21870933 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215864 Fri, 26 Aug 2011 04:00:00 +0100 5215864 http://www.medworm.com/index.php?rid=5215863&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21870934%26dopt%3DAbstract Authors: Wu T, Zhang QW, Zhang XQ, Liu G, Wang L, Jiang MM, Feng YF, Ye WC Abstract A new triterpenoid glycoside, heterobetulinic acid 3-O-β-D-glucopyranosyl(1 → 2)-β-D-xylopyranoside (1), together with a new phenylacrylic acid derivative, 3'S,4'-dihydroxyl-2'-methylene-but-1'-enyl caffeate (2), were isolated from the roots of Ilex pubescens. Their structures were elucidated by HR-ESI-MS, 1-D and 2-D NMR analyses and chemical methods. In addition, the absolute configuration of 2 was established by the application of a modified Mosher's method. PMID: 21870934 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215863 Fri, 26 Aug 2011 04:00:00 +0100 5215863 http://www.medworm.com/index.php?rid=5215862&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21870936%26dopt%3DAbstract Authors: Tripathi AC, Gupta R, Saraf SK Abstract The ethanol extract of the dried, powdered hull portion of Ricinus communis seeds indicated the presence of alkaloids, steroids, flavonoids, glycosides and phenolics, amongst others. Ricinine was isolated as an active constituent and characterised by various chemical and spectroscopic techniques. The anticonvulsant activity of the isolated compound was evaluated in mice using the maximal electroshock (MES) model. The isolated compound at a dose of 60 mg kg(-1) body weight, orally, significantly (p < 0.05) reduced the extensor tonus phase of convulsion by MES-induced seizures in albino mice when compared with the standard drug diazepam (30 mg kg(-1) body weight, orally). The results of this study support the folkloric u... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5215862 Fri, 26 Aug 2011 04:00:00 +0100 5215862 http://www.medworm.com/index.php?rid=5171554&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21867456%26dopt%3DAbstract Authors: Ezzat SM, Abdallah HM, Fawzy GA, El-Maraghy SA Abstract An investigation of the aqueous ethanolic extract (AE) of the aerial parts of Torilis radiata Moench yielded two triterpenes (lupeol acetate (1) and α-amyrin (2)), a sterol (spinasterol (3)) from its n-hexane fraction (HF), a flavone (acacetin (4)), a coumarin (scopoletin (5)), a phenolic acid (ferulic acid (6)) from the chloroform fraction (CF) and a flavone glycoside (luteolin-7-O-glucoside (7)) from the n-butanol fraction (BF). The hepatoprotection of the AE and its fractions was assessed in terms of the reduction in histological damage, accompanied by restoration of the liver enzymes (alanine amino transferase (ALT), aspartate amino transferase (AST), lactate dehydrogenase (LDH)), a reduction in the inflammatory ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171554 Thu, 25 Aug 2011 23:00:00 +0100 5171554 http://www.medworm.com/index.php?rid=5171549&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21867457%26dopt%3DAbstract Authors: Gui-Rong C, Li-Ping C, De-Qiang D, Ting-Guo K, Hong-Fu L, Fu-Rui L, Ning J Abstract The natural dibenzylbutyrolactone type lignanolide (-)-arctigenin, which was prepared from fructus arctii, showed obvious anticancer activity. The synthesis of four new (-)-arctigenin derivatives and their anticancer bioactivities were examined. The structures of the four new synthetic derivatives were elucidated. PMID: 21867457 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171549 Thu, 25 Aug 2011 23:00:00 +0100 5171549 http://www.medworm.com/index.php?rid=5171548&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21867458%26dopt%3DAbstract Authors: El-Alfy TS, Ezzat SM, Sleem AA Abstract A chemical study of the red type of the seeds of Eragrostis tef (Zucc.) Trotter (Poaceae) led to the isolation of seven compounds from its ethanol extract, namely β-sitosterol (1), β-amyrin-3-O-(2'-acetyl(glucoside (2), β-sitosterol-3-O-β-D-glucoside (3), naringenin (4), naringenin-4'-methoxy-7-O-α-L-rhamnoside (5), eriodictyol-3',7-dimethoxy-4'-O-β-D-glucoside (6) and isorhamnetin-3-O-rhamnoglucoside (7), which are reported for the first time in the genus Eragrostis. This is the first report for the isolation of compounds (2) and (6) in nature. The isolated compounds were identified using different spectroscopic methods (EIMS, UV, (1)H NMR, (13)C NMR, HMQC and HMBC). A proximate analysis revealed the high nutritive value of th... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171548 Thu, 25 Aug 2011 23:00:00 +0100 5171548 http://www.medworm.com/index.php?rid=5171569&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21867394%26dopt%3DAbstract Authors: Ying X, Meng X, Wang S, Wang D, Li H, Wang B, Du Y, Liu X, Zhang W, Kang T Abstract A simple and sensitive HPLC method was developed to simultaneously determine three active compounds, vitexin-4″-O-glucoside (VG), vitexin-2″-O-rhamnoside (VR) and hyperoside (HP), in rat plasma after administering the hawthorn leaves extract (HLE). An HPLC assay with baicalin as the internal standard was carried out using a Phenomsil C(18) analytical column with UV detection at 332 nm. The mobile phase consisted of methanol-acetonitrile-tetrahydrofuran-1% glacial acetic acid (6 : 1.5 : 18.5 : 74, v/v/v/v). The calibration curves were linear over the range of 2.5-500, 0.2-25 and 0.25-12.5 µg mL(-1) for VG, VR and HP, respectively. The method was reproducible and reliab... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171569 Wed, 24 Aug 2011 23:00:00 +0100 5171569 http://www.medworm.com/index.php?rid=5171572&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21861767%26dopt%3DAbstract Authors: Rahimi-Nasrabadi M, Ahmadi F, Batooli H Abstract The chemical composition of the essential oil of leaves of Eucalyptus procera Dehnh., cultivated in central Iran, was obtained by hydrodistillation and analysed by GC-MS. Forty-five constituents representing 99.6% of the total oil were identified. The main constituents of the oil were found to be 1,8-cineole (35.9%), α-pinene (25.6%) and viridiflorol (7.7%). Other representative compounds were identified as α-terpineol (3.6%), aromadendrene (3.5%) and trans-pinocarveol (3.0%). PMID: 21861767 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171572 Tue, 23 Aug 2011 23:00:00 +0100 5171572 http://www.medworm.com/index.php?rid=5171571&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21861768%26dopt%3DAbstract This study was undertaken to isolate a flavonol, kaempferol, from the fruits of Lagenaria siceraria (bottle gourd) as a sole compound and to explore the fibrinolytic potential of the methanolic extract of the fruits of L. siceraria and the isolated compound using their in vitro activity. The fibrinolytic activity in terms of percentage of plasma clot liquefaction was determined by plasma clot lysis at 37°C in 24 h. The fibrinolytic activity of both substances was compared to the well-known thrombolytic agent streptokinase (30,000 IU). The percentage of fibrinolytic activity of the extract and isolated compound were found to be 54.72 ± 0.7210 and 77.37 ± 1.3010, respectively. Streptokinase was considered as the standard fibrinolytic enzyme for comparative purposes and had 91... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171571 Tue, 23 Aug 2011 23:00:00 +0100 5171571 http://www.medworm.com/index.php?rid=5171570&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21861769%26dopt%3DAbstract Authors: Yang XN, Kang SC Abstract The antioxidant activities of the water and ethanol extracts of F. koreana flowers were evaluated using DPPH, superoxide anion (•[Formula: see text]), and nitric oxide (•NO) radical scavenging activity assays. The SC(50) values of the water extract of F. koreana on DPPH, •[Formula: see text] and •NO were 48.39, 24.36 and 100.21 µg mL(-1), respectively. The SC(50) values of the ethanol extract of F. koreana on the aforesaid free radicals were 57.50, 49.00 and 146.08 µg mL(-1), respectively. Further, the total phenolic contents of both extracts were determined and expressed as milligram gallic acid equivalent (GAE) per gram of extract. The water extract exhibited a higher phenolic content (113.78 mg GAE g(-1)), while the ethano... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171570 Tue, 23 Aug 2011 23:00:00 +0100 5171570 http://www.medworm.com/index.php?rid=5171588&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21859369%26dopt%3DAbstract In this study, the volatile constituents from the ethanolic extract of broccolini leaves were analysed by gas chromatography-mass spectrometry (GC-MS). Sixteen compounds were identified. The major components include 5-phenyl-undecane (11%), n-hexadecanoic acid (9.34%), octadecanoic acid (6.39%), 1,1,3-trimethyl-3-phenyl-indan (4.0%), 3-(2-phenylethyl)benzonitrile (3.48%) and phytol (3.37%). PMID: 21859369 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171588 Mon, 22 Aug 2011 23:00:00 +0100 5171588 http://www.medworm.com/index.php?rid=5171587&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21859370%26dopt%3DAbstract In conclusion, these findings indicate that the integument body wall of S. hermanni and S. vastus is a rich source of sulphated GAGs. PMID: 21859370 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171587 Mon, 22 Aug 2011 23:00:00 +0100 5171587 http://www.medworm.com/index.php?rid=5171586&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21859371%26dopt%3DAbstract This study also showed that phenolics may contribute maximally to HRS (R (2) = 0.9236) and MCA (R (2) = 0.9396) and to a lesser extent to NOS activity (R (2) = 0.5819) and the β-carotene-linoleic acid assay (R (2) = 0.8213). The data obtained in the in vitro models clearly establish the antioxidant potency of leaf extracts of C. occidentalis. PMID: 21859371 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171586 Mon, 22 Aug 2011 23:00:00 +0100 5171586 http://www.medworm.com/index.php?rid=5171585&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21859372%26dopt%3DAbstract In conclusion, F. mysorensis recorded hypolipidaemic and antioxidant effects. Detailed studies of the isolated compounds must be undertaken for an evaluation against hypercholesterolemia and free radical elevation. PMID: 21859372 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171585 Mon, 22 Aug 2011 23:00:00 +0100 5171585 http://www.medworm.com/index.php?rid=5171584&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21859373%26dopt%3DAbstract We describe in this article a process with which to obtain different ketones related to oleanolic and ursolic acids from a natural source, Salvia canariensis L., with minimal use of chromatography columns. Amongst the isolated compounds was 12α-bromo-3-oxo-olean-13, 28-olide (3), which was fully characterised, including a characterisation of its molecular configuration by X-ray crystallographic analysis by 1 and 2-dimensional NMR techniques. PMID: 21859373 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171584 Mon, 22 Aug 2011 23:00:00 +0100 5171584 http://www.medworm.com/index.php?rid=5171583&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21859374%26dopt%3DAbstract Authors: Dağdelen A, Tümen G, Ozcan MM, Dündar E Abstract The tocopherol contents of oils obtained from Ayvalık, Domat and Gemlik olive varieties harvested at different ripening periods were evaluated by high-performance liquid chromatography. α-Tocopherol was the major tocol detected in all the studied olive oil samples. The oils extracted from olive fruits composed of 130.54-180.43 mg kg(-1) α-tocopherol, 0.73-1.61 mg kg(-1) β-tocopherol and 0.53-2.28 mg kg(-1) γ-tocopherol for Ayvalık oil. The α-, β- and γ-tocopherol contents of Domat oil are in the ranges 95.60-125.56, 0.71-2.70 and 0.49-1.25 mg kg(-1) at different harvesting periods. The α-, β- and γ-tocopherol contents of Gemlik olive oil are in the ranges 112.59-168.19, 0.94-1.21 and 0.85-2.40�... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171583 Mon, 22 Aug 2011 23:00:00 +0100 5171583 http://www.medworm.com/index.php?rid=5171582&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21859375%26dopt%3DAbstract Authors: Guo Z, Zhao A, Chen T, Xie G, Zhou M, Qiu M, Jia W Abstract Historically, Schisandra chinensis and S. sphenanthera have been widely used in traditional Chinese medicine. Although both species are in the genus Schisandra, they have dissimilar therapeutic effects that may be attributed to compositional differences in secondary metabolites. We developed a method to compare these metabolites obtained from the above plant species using ultra-performance liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry coupled with multivariate statistical analyses. The critical markers we used to discriminate between both plant species resulted in the identification and quantification of six lignans and seven essential oils. We believe that our approach provided ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=5171582 Mon, 22 Aug 2011 23:00:00 +0100 5171582