MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Natural Product Research' source. Thu, 18 Mar 2010 16:20:04 +0100 http://www.medworm.com/index.php?rid=3336035&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20198535%26dopt%3DAbstract Authors: Cheng MJ, Wang TA, Lee SJ, Chen IS The chloroform-soluble portion of the leaf extract of Litsea lii var. nunkao-tahangensis was further studied and these studies led to the isolation of a new butanolide, litsealiicolide C (1), and a new secobutanolide, secoisolitsealiicolide B (2), along with seven known compounds, linderanolide B (3), isolinderanolide C (4), secolincomolide A (5), secokotomolide A (6), (+)-beta-eudesmol (7), trans-phytol (8), and (-)-matairesinol (9). Their structures were established on the basis of spectral analysis and comparison with the literature data. In addition, the cytotoxicities against MCF-7, NCI-H460, and SF-268 cancer cell lines were measured in vitro and the results demonstrated that these metabolites have no cytotoxicity against the selected t... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3336035 Tue, 02 Mar 2010 00:00:00 +0100 3336035 http://www.medworm.com/index.php?rid=3311408&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20182949%26dopt%3DAbstract Authors: Dhanasekaran D, Thajuddin N, Panneerselvam A About 64 total actinomycetes were isolated from various coastal soils. Sixteen actinomycete isolates were screened for herbicidal principles. Out of these, five potent isolates were selected for characterisation and identification. Based on their morphological, biochemical and physiological characteristics, the actinomycete isolates were identified as Glyomyces, Saccharomonospra and Streptomyces sp. The Streptomycetes isolates were tested for herbicidal principles by germination inhibition assay. About 10 crop seeds were tested for herbicidal activity with Streptomycetes isolates. The crop seeds did not show growth inhibition. Four weed seeds were tested for herbicidal activity with Streptomyces isolates. Streptomyces inhibits the g... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3311408 Wed, 24 Feb 2010 00:00:00 +0100 3311408 http://www.medworm.com/index.php?rid=3311410&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20182947%26dopt%3DAbstract Authors: Jain N, Jain R, Jain A, Jain DK, Chandel HS The aim of the present study was to assess the wound-healing activity of ethanolic extracts of Acorus calamus leaves. A wound was induced by an excision- and incision-based wound model in rats of either sex. The mature green leaves of A. calamus were collected and authenticated. Extractions of dried leaves were carried out with 80% ethanol in a soxhlet apparatus. For wound-healing activity, the extracts were applied topically once daily in conc. of 40% w/w and 20% w/w in the form of ointment and compared with a standard drug (povidion-iodine). The healing of the wound was assessed by the rate of wound closure, period of epithelialisation, tensile strength and weight of the granulation tissue, hydroxyproline content and histopathology... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3311410 Tue, 23 Feb 2010 00:00:00 +0100 3311410 http://www.medworm.com/index.php?rid=3311409&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20182948%26dopt%3DAbstract Authors: Xie CF, Qu JB, Wu XZ, Liu N, Ji M, Lou HX Six macrocyclic bis(bibenzyls) were obtained from the Chinese liverwort Ptagiochasm intermedlum L., and their structures were elucidated as pakyonol (1), neomarchantin A (2), isoriccardin C (3), marchantin H (4), riccardin F (5) and riccardin C (6) on the basis of spectroscopic data and comparison with known compounds. Among them, compounds 3-5 were isolated from this liverwort species for the first time. They possessed in vitro antifungal properties against the fluconazole-sensitive and resistant strains of Candida albicans, with minimum inhibitory concentrations (MICs) ranging from 32 to >512 microg mL(-1). Furthermore, riccardin C was also demonstrated to act as a fungal resistance modifying agent when its combined effect with fl... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3311409 Tue, 23 Feb 2010 00:00:00 +0100 3311409 http://www.medworm.com/index.php?rid=3311407&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20182950%26dopt%3DAbstract Authors: Ding L, Liu B, Zhang SD, Hou Q, Qi LL, Zhou QY Four xanthones were isolated from Gentianopsis paludosa Ma and were identified by modern spectroscopic methods. Cytotoxicity of the four xanthones was tested on HepG2 cells and HL-60 cells by sulphorhodamine B (SRB) assay. Clonogenic survival assay, trypan blue exclusion method, AO/EB staining and DNA fragmentation assay were conducted to investigate the effect on growth inhibition and apoptosis in the two cell lines in vitro. At the same time, structure-activity relationships (SARs) of the xanthones were investigated. The results showed that the xanthones had significant cytotoxicity and inhibition of proliferation in both HepG2 cells and HL-60 cells, and could induce apoptosis in these two cell lines. SARs indicated that the met... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3311407 Tue, 23 Feb 2010 00:00:00 +0100 3311407 http://www.medworm.com/index.php?rid=3291294&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20169502%26dopt%3DAbstract Authors: Sethi A, Bhatia A, Srivastava S, Bhatia G, Khan MM, Khanna AK, Saxena JK A new pregnane glycoside hindicusine (1) was isolated from the CHCl(3)-EtOH (3 : 2) extract of Hemidesmus indicus, whose structure was established on the basis of spectroscopic studies. The glycoside (1) and its acetylated derivative (5) were evaluated for their anti-oxidant and anti-dyslipidemic activities. PMID: 20169502 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3291294 Thu, 18 Feb 2010 00:00:00 +0100 3291294 http://www.medworm.com/index.php?rid=3255011&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20140799%26dopt%3DAbstract Authors: Niederhofer H There is evidence for the efficacy of noradrenaline and serotonin reuptake inhibitors treating attention-deficit hyperactivity disorder (ADHD). In this open trial, we checked St. John's wort, a serotonin and noradrealine reuptake inhibitor, and actually used as an antidepressant, for this indication. Three 14-16-year-old male psychiatric outpatients, diagnosed with ADHD have been rated at baseline and while taking St. John's wort or a placebo, respectively, by the Conner Scale and by the Continuous Performance Test, to determine its efficacy as a treatment option for ADHD. Patients' mean scores improved for Conners' hyperactivity, inattention and immaturity factors. Although the sample size is very small and therefore generalisation is very difficult, this observ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3255011 Mon, 01 Feb 2010 00:00:00 +0100 3255011 http://www.medworm.com/index.php?rid=3255010&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20140800%26dopt%3DAbstract Authors: Surveswaran S, Cai YZ, Xing J, Corke H, Sun M The subfamily Asclepiadoideae (Apocynaceae) and the closely-related Periplocoideae are sources of many indigenous Indian medicinal plants. We surveyed antioxidant properties and total phenolic and flavonoid contents of 15 samples, representing 12 Indian medicinal plant species from these subfamilies. Total antioxidant assay was performed using the 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid and ferric-reducing antioxidant power methods. Total phenolic and flavonoid contents were measured using colourimetric methods. Principal phenolic compounds were detected by liquid chromatography-mass spectrometry (LC-MS). The highest antioxidant capacity and high levels of total phenolics and flavonoids were found in the leaves of Decal... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3255010 Mon, 01 Feb 2010 00:00:00 +0100 3255010 http://www.medworm.com/index.php?rid=3255009&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20140801%26dopt%3DAbstract Authors: van Rijn RM, Rhee IK, Verpoorte R Alzheimer's disease (AD) is associated with a steady loss of attention and memory, which has been correlated with the impairment of brain cholinergic neurotransmission, particularly a deficit of cholinergic neurons in the nucleus basalis of Meynert. Therefore, one of the methods that has proven successful in the treatment of AD is the use of inhibitors of acetylcholinesterase (AchE) to supplement the acetylcholine level. Herein we describe the isolation of several AchE-inhibiting alkaloids from the bulbs of Nerine bowdenii, an Amaryllidaceae species. For the first time 11-O-acetylambelline and filofiline, previously reported from Brunsvigia josephinea and Nerine filifolia, respectively, were isolated. PMID: 20140801 [PubMed - in process] (... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3255009 Mon, 01 Feb 2010 00:00:00 +0100 3255009 http://www.medworm.com/index.php?rid=3255008&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20140802%26dopt%3DAbstract In this study, the extracellular activity of C. nutans extracts against HSV-2 infected on HEp-2 cells was investigated in terms of its molecular aspects. HSV-2 was treated with the extracts and adsorped into the HEp-2 cells. After infection, HSV-2 DNA quantities in the infected cells were assessed and compared by the quantitative dot blot hybridisation technique. The results showed that treating the viruses with either less or more highly purified extracts before infection resulted in great reductions of viral infectivity. Further investigation was performed by Western blot analysis to determine the activities of the extracts on the viral proteins. At least eight viral proteins of the infected cell proteins (ICP) and some structural proteins, including 146, 125, 78, 69, 55, 44, 40 and 20 K... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3255008 Mon, 01 Feb 2010 00:00:00 +0100 3255008 http://www.medworm.com/index.php?rid=3255007&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20140803%26dopt%3DAbstract In conclusion, we record here F. vesceritensis as a new natural source of lapiferin and its first X-ray analysis, and the promising specific anti-cancer activity against human breast cancer of lapiferin and accordingly F. vesceritensis extract. PMID: 20140803 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3255007 Mon, 01 Feb 2010 00:00:00 +0100 3255007 http://www.medworm.com/index.php?rid=3255006&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20140804%26dopt%3DAbstract Authors: Singh AB, Tamarkar AK, Narender T, Srivastava AK The present report confirms the anti-hyperglycaemic and anti-dyslipidemic properties of 4-hydroxyisoleucine, an unusual amino acid isolated from Trigonella foenum-graecum seeds, for the first time in a well-characterised model of type II diabetes, i.e. db/db mice. 4-Hydroxyisoleucine, when given orally to these mice at 50 mg kg(-1) dose level, significantly (p < 0.05) declined their elevated blood glucose, plasma insulin, triglycerides, total cholesterol, low-density lipoprotein-cholesterol levels and raised their declined plasma high-density lipoprotein-cholesterol level. These results indicate that 4-hydroxyisoleucine exhibits significant potential as an anti-diabetic agent by suppressing progression of type II diabetic sta... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3255006 Mon, 01 Feb 2010 00:00:00 +0100 3255006 http://www.medworm.com/index.php?rid=3255005&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20140805%26dopt%3DAbstract Authors: Okoye FB, Osadebe PO Alchornea floribunda leaves are widely used in African ethnomedicine for the management of acute and chronic inflammatory disorders. In the present study, bioactivity-guided fractionation of the ethyl acetate fraction of the methanol leaf extract of the plant material led to the isolation of a new flavonol glycoside (AFF1). The anti-inflammatory activity of this novel compound was evaluated using egg albumen-induced rat paw oedema as a model of inflammation. AFF1 showed significant inhibition of the rat paw oedema in a dose-dependent manner. The activity of AFF1 (50 mg kg(-1)) was higher than that of the standard anti-inflammatory drug, aspirin (100 mg kg(-1)). The compound also significantly (p < 0.001) inhibited heat-induced haemolysis of human erythr... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3255005 Mon, 01 Feb 2010 00:00:00 +0100 3255005 http://www.medworm.com/index.php?rid=3255004&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20140806%26dopt%3DAbstract In this study, we looked at the effect of ouabain, digoxin and proscillaridin A on human fibroblasts. These data show that low concentrations of ouabain, digoxin and proscillaridin A can activate proliferation of human fibroblasts, suggesting that the Na(+), K(+)-adenosine triphosphatase complex may act as a transducing receptor. It was shown that 30 nM ouabain, digoxin and proscillaridin A stimulated an antiapoptotic action by the increase in the level of phosphorylated extracellular signal-regulated kinases (P-ERK 1/2). Ouabain, digoxin and proscillaridin A only at the relatively high concentration of 300 nM increased intracellular Ca(2+) concentration, activated caspase-3 and induced apoptosis in human fibroblasts. In terms of reduction in cell viability, antiproliferative and apoptotic... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3255004 Mon, 01 Feb 2010 00:00:00 +0100 3255004 http://www.medworm.com/index.php?rid=3255003&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20140807%26dopt%3DAbstract Authors: Tocci N, Ferrari F, Santamaria AR, Valletta A, Rovardi I, Pasqua G Hypericum perforatum is an important medicinal plant containing numerous biologically active compounds. The effect of chitosan elicitation on xanthone biosynthesis in calli and in cell suspension cultures of H. perforatum subsp. angustifolium was evaluated. Elicited cell cultures showed an increase in xanthone production and a simultaneous decrease in flavonoid production. Chitosan also induced the production of 1,7-dihydroxyxanthone (euxanthone) and cadensin G, which were not detected in either the calli nor the non-elicited cell cultures. 1,7-Dihydroxyxanthone was in part (21%) released in the culture medium. PMID: 20140807 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3255003 Mon, 01 Feb 2010 00:00:00 +0100 3255003 http://www.medworm.com/index.php?rid=3255002&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20140808%26dopt%3DAbstract Authors: Liu HW, Li JK, Zhang DW, Zhang JC, Zhang X, Song XH, Xia Y, Wang NL, Yao XS, Cai GP A new glycoside compound (1) was isolated from the starfish Asteria amurensis Lutken. The structure for compound 1 was identified as 1-O-{beta-D-quinovopyranosyl-(1-2)-beta-D-fucopyranosyl-(1-4)-[beta-D-fucopyranosyl(1-2)] beta-D-quinovopyranosyl}-butanol by extensive NMR experiments as well as chemical evidence. The effects of compound 1 on UMR106 cell proliferation were screened by MTT assay. The results indicate that compound 1 (0.01-100 microM) significantly promotes osteoblastic proliferation. PMID: 20140808 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3255002 Mon, 01 Feb 2010 00:00:00 +0100 3255002 http://www.medworm.com/index.php?rid=3255001&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20140809%26dopt%3DAbstract Authors: Jain S, Jain A, Jain N, Jain DK, Balekar N We evaluate the in vitro free radical scavenging activity of the leaves of Tabernaemontana divaricata Linn. Petroleum ether, ethanol and aqueous extracts of T. divaricata were prepared with successive extraction in a soxhlet apparatus. Each extract was selected to study the free radical scavenging activity by superoxide scavenging assay method. It was found that the aqueous extract contained carbohydrates, glycosides, amino acids, flavonoids, tannins, alkaloids, and steroids, and the ethanolic extract contained glycosides, amino acids, flavonoids, tannins, alkaloids and steroids. The ethanolic extract of T. divaricata showed 58.7 +/- 0.62% inhibition in the superoxide scavenging model. The aqueous extract also showed almost similar ac... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3255001 Mon, 01 Feb 2010 00:00:00 +0100 3255001 http://www.medworm.com/index.php?rid=3177527&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20077302%26dopt%3DAbstract Authors: Cuong NM, Tai BH, Hoan DH The analysis of 1D- and 2D-NMR spectroscopic data confirmed that the amino N-1' protons of indirubin and indirubin-3'-oxime resonate at a higher frequency than N-1 protons. The amino N-1' protons in both indirubin and indirubin-3'-oxime are not favourable for acetylated reaction due to their intramolecular hydrogen bonding with the amide carbonyl group. The new N-1-acetylindirubin-3'-acetoxime has been synthesised using acetic anhydride. The reassignment of the NMR data of indirubin, indirubin-3'-oxime and N-1-acetylindirubin was confirmed with the aid of DEPT, HSQC, HMBC and NOESY methods. PMID: 20077302 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3177527 Sat, 16 Jan 2010 14:36:03 +0100 3177527 http://www.medworm.com/index.php?rid=3177526&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20077303%26dopt%3DAbstract Authors: Vergara-Galicia J, Aguirre-Crespo F, Castillo-Espana P, Arroyo-Mora A, Lopez-Escamilla AL, Villalobos-Molina R, Estrada-Soto S A simple and efficient protocol has been developed in order to obtain healthy seedlings by asymbiotic germination of seeds from Laelia autumnalis. Seeds from mature capsules were germinated asymbiotically after being cultured on full- or half-strength Murashige and Skoog's (MS) medium, without plant growth regulators and with 3.0% or 1.5% of sucrose. The percentage of germinated seeds (% GS) was recorded during 6 weeks using three different conditions of incubation: light (80% GS, p < 0.05), darkness (30% GS) and white light photoperiod (100% GS, p < 0.05). The best seed germination percentages were found on the light and white light photoperiod ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3177526 Sat, 16 Jan 2010 14:36:03 +0100 3177526 http://www.medworm.com/index.php?rid=3177525&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20077304%26dopt%3DAbstract Authors: Zhao H, Xie WD, Row KH A new eremophilenolactone sesquiterpene was isolated from the roots of Senecio ambraceus. Its structure was elucidated as 6beta-angeloyloxy-eremophila-1(10),7(11)-diene-12,8beta-lactone on the basis of spectroscopic analysis, including IR, electron ionisation mass spectrometry, high-resolution electrospray ionisation mass spectrometry, 1D and 2D NMR spectroscopy. PMID: 20077304 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3177525 Sat, 16 Jan 2010 14:36:03 +0100 3177525 http://www.medworm.com/index.php?rid=3177524&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20077305%26dopt%3DAbstract Authors: Mehta BK, Mehta D, Itoriya A Phytochemical investigation of Centratherum anthelminticum seeds resulted in the isolation of two novel glycosides. The pentacyclic triterpenoid saponins were shown to contain hederagenin and sugar residues forming two glycosyl chains. The structural analysis of its acetylated derivative was determined using a combination of homo- (1D (1)H NMR, (13)C NMR and (13)C NMR-DEPT) and heteronuclear 2D NMR techniques ((1)H-(1)H-COSY, total correlated spectroscopy (TOCSY), heteronuclear multiple quantum coherence (HMQC)), heteronuclear multiple bond correlation (HMBC) and chemical methods. The structure of the saponins were established to be 3-O-[beta-D-glucopyranosyl-(1 --> 2)-alpha-L-rhamnopyranosyl-(1 --> 2)-alpha-L-arabinopyranosyl]-28-O-[beta-D-x... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3177524 Sat, 16 Jan 2010 14:36:03 +0100 3177524 http://www.medworm.com/index.php?rid=3177521&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20077306%26dopt%3DAbstract Authors: Asghar SF, Choudhary MI Phytochemical investigations on the methanol extract of Iris germanica resulted in the isolation of a new benzene derivative, 2'-methyl-6'-hydroxy cyclohexenyl-3-methyl-1-acetophenone ether (1). Further, another known benzene derivative, isopenol (2), also afforded two known isoflavones, irisolone (3) and irisolidone (4). The structure of the new compound was determined on the basis of spectroscopic data, including 2D-NMR experiments, while the known compounds were identified on the basis of their spectral data and existing literature evidence. The comparison of the spectral data of the irisolidone (3) with that reported for the molecule led us to revise some of the reported (1)H-NMR chemical shift assignments. PMID: 20077306 [PubMed - in process] (... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3177521 Sat, 16 Jan 2010 14:36:03 +0100 3177521 http://www.medworm.com/index.php?rid=3177519&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20077307%26dopt%3DAbstract Authors: Yang SA, Jeon SK, Lee EJ, Shim CH, Lee IS The antioxidant activities and the determined major components of six popular and commercially available herb essential oils, including lavender (Lavendular angustifolia), peppermint (Mentha piperita), rosemary (Rosmarius officinalis), lemon (Citrus limon), grapefruit (Citrus paradise), and frankincense (Boswellia carteri), were compared. The essential oils were analysed by GC-MS and their antioxidant activities were determined by testing free radical-scavenging capacity and lipid peroxidation in the linoleic acid system. The major components of the essential oils of lavender, peppermint, rosemary, lemon, grapefruit, and frankincense were linalyl acetate (28.2%), menthol (33.4%), 1,8-cineole (46.1%), limonene (64.5 and 94.2%), and p-me... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3177519 Sat, 16 Jan 2010 14:36:03 +0100 3177519 http://www.medworm.com/index.php?rid=3177518&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20077308%26dopt%3DAbstract Authors: Alali FQ, Gharaibeh AA, Ghawanmeh A, Tawaha K, Qandil A, Burgess JP, Sy A, Nakanishi Y, Kroll DJ, Oberlies NH A new colchicinoid from Colchicum crocifolium Boiss. (Colchicaceae) was isolated and identified as N,N-dimethyl-N-deacetyl-(-)-cornigerine (5), along with four known compounds, but new to the species: (-)-colchicine (1), (-)-demecolcine (2), (-)-N-methyl-(-)-demecolcine (3) and 3-demethyl-N-methyl-(-)-demecolcine (4). All isolated compounds showed potent cytotoxicity against a human cancer cell panel. PMID: 20077308 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3177518 Sat, 16 Jan 2010 14:36:03 +0100 3177518 http://www.medworm.com/index.php?rid=3177517&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20077309%26dopt%3DAbstract Authors: Siddiqui BS, Perwaiz S, Begum S, Ali ST Isolation and structure elucidation of three new natural constituents are reported. These include a new substituted furfuryl ester of stearic acid, latifolinal (1), and two aromatic compounds, latifolidin (2) and cordicinol (3). Compounds 1 and 2 were obtained from the dried fruits and compound 3 from the leaves of Cordia latifolia. PMID: 20077309 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3177517 Sat, 16 Jan 2010 14:36:03 +0100 3177517 http://www.medworm.com/index.php?rid=3177516&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20077310%26dopt%3DAbstract Authors: Parveen M, Khanam Z, Ali M, Rahman SZ A new triterpenic glucoside, lup-1,5,20(29)-trien-3-O-beta-D-glucopyranoside (4), along with three known phytoconstituents: n-octacosane, friedelin and beta-amyrin, has been isolated from the leaves of Clerodendrum inerme (L.) Gaertn. (Verbenaceae). Structure elucidation was carried out on the basis of chemical and physical evidence (IR, (1)H-NMR, (13)C-NMR, DEPT and MS spectra). The alcoholic and aqueous extracts of the leaves of C. inerme showed significant antinociceptive activity in analgaesiometer tests. PMID: 20077310 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3177516 Sat, 16 Jan 2010 14:36:03 +0100 3177516 http://www.medworm.com/index.php?rid=3177499&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20077311%26dopt%3DAbstract Authors: Parra A, Lopez PE, Garcia-Granados A Some deoxygenation pathways were tested to remove the hydroxyl groups of the natural triterpenes oleanolic acid and maslinic acid to obtain a practical starting material for the semisynthesis of other interesting organic synthons. Different deoxygenation processes were carried out starting from these triterpenic acids or from several derivatives such as methyl esters and epoxy derivatives. The hydroxyl groups were transformed into some intermediate compounds including xanthyl, thiocarbonyl or tosyl derivatives. The opening of the oxirane ring between C-2 and C-3 was also achieved through different methods using deoxygenating reagents such as Me(3)SiCl/NaI, WCl(4)/n-BuLi and Cp(2)TiCl. PMID: 20077311 [PubMed - in process] (Source: Natura... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3177499 Sat, 16 Jan 2010 14:36:03 +0100 3177499 http://www.medworm.com/index.php?rid=3177494&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20077312%26dopt%3DAbstract Authors: Rohini RM, Das AK Three triterpenoids from the chloroform extract of the stem bark of Rhizophora mucronata (Rhizophoraceae) were isolated. The structures of these isolated compounds were identified by spectroscopic analysis as 3beta-O-(E)-(4-methoxy) cinnamoyl-15 alpha-hydroxyl beta-amyrin (1), adian-5-en 3-ol (2) and lupeol (3). Such compounds are being reported for the first time from this plant. PMID: 20077312 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3177494 Sat, 16 Jan 2010 14:36:03 +0100 3177494 http://www.medworm.com/index.php?rid=3105467&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013465%26dopt%3DAbstract Authors: Iqbal Choudhary M, Atif M Transformation of lynestrenol (19-nor-17alpha-pregn-4-en-20-yn-17beta-ol) (1) was carried out by incubation with Cunninghamella elegans to obtain 19-nor-17alpha-pregn-4-en-20-yn-3-one-10beta,17beta-diol (2), 19-nor-17alpha-pregn-4-en-20-yn-3-one-6beta,17beta-diol (3), and 19-nor-17alpha-pregn-4-en-20-yn-3beta,6beta,17beta-triol (4). Metabolite 4 was identified as a new compound. These metabolites were structurally characterised on the basis of spectroscopic techniques. PMID: 20013465 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105467 Sat, 19 Dec 2009 18:28:41 +0100 3105467 http://www.medworm.com/index.php?rid=3105466&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013466%26dopt%3DAbstract Authors: Aravind S, Balachandran J, Ramanujam Ganesh M, Krishna Kumari GN Reinvestigation of the acetone extract of Teucrium tomentosum yielded a new neo-clerodane diterpenoid, teuctomin (1), along with 6-O-acetyl-teucmicropodin (2), teugracilin-A (3), 6alpha-hydroxyteuscordin (4) and 6alpha-acetoxyteuscordin (5). The structure of the new compound was elucidated comprehensively using 1D and 2D NMR methods. Compounds showed effective antifeedancy against Plutella xylostella at 10 mug cm(-2) of leaf area. PMID: 20013466 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105466 Sat, 19 Dec 2009 18:28:39 +0100 3105466 http://www.medworm.com/index.php?rid=3105465&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013467%26dopt%3DAbstract Authors: Dong LP, Chen CX, Ni W, Xie BB, Li JZ, Liu HY A new dinorclerone diterpenoid glycoside, named 1-deacetyltinosposide A (1), was isolated from the stem of Tinospora sinensis together with 10 known compounds. Their structures were elucidated on the basis of extensive spectroscopic techniques (MS, IR, 1D and 2D NMR experiments). PMID: 20013467 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105465 Sat, 19 Dec 2009 18:28:36 +0100 3105465 http://www.medworm.com/index.php?rid=3105464&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013468%26dopt%3DAbstract Authors: Perveen S, Yasmin A, Khan KM The reaction of isocyanates and isothiocyanates with long-chain alcohols, e.g. n-hexanol, n-heptanol and n-octanol, exclusively gave N-aryl-O-alkyl carbamates, while N-aryl-O-alkyl carbamates were formed along with symmetrical 1,3-disubstituted ureas and thioureas when the same reactions were carried out with small-chain alcohols at room temperature without using any solvent. PMID: 20013468 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105464 Sat, 19 Dec 2009 18:28:34 +0100 3105464 http://www.medworm.com/index.php?rid=3105463&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013469%26dopt%3DAbstract Authors: Belliveau KA, Romero-Zeron LB A simple procedure for extracting and purifying sinigrin from Oriental mustard (Brassica juncea) meal using cold water was developed. Subsequently, the chemical degradation of sinigrin due to enzymatic activity was monitored using (1)H NMR spectroscopy over the course of 30 h. The experimental findings show that sinigrin has been positively identified from B. juncea using (1)H NMR spectroscopy and the prescribed preparation procedure. The results that have been presented also offer unambiguous evidence that (1)H NMR spectroscopy can be used to detect changes in sinigrin concentration over time. PMID: 20013469 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105463 Sat, 19 Dec 2009 18:28:31 +0100 3105463 http://www.medworm.com/index.php?rid=3105462&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013470%26dopt%3DAbstract Authors: Aykac A, Akgul Y New analogues of a long-chain secondary alcohol (1) and laserine (2) were isolated from the flowers of Tamarix hampeana L. The isolated compounds were identified using 1D and 2D NMR, LCMS/APCI, and chemical methods. Laserine was isolated for the first time from T. hampeana L. PMID: 20013470 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105462 Sat, 19 Dec 2009 18:28:29 +0100 3105462 http://www.medworm.com/index.php?rid=3105461&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013471%26dopt%3DAbstract Authors: Dou DQ, Tian F, Qiu YK, Xiang Z, Xu BX, Kang TG, Dong F The extract from the leaves of Smallantus sonchifolius (yacon) was found to show potent anti-diabetic activity. Two new diterpenes, named ent-kaurane-3beta,16beta,17, 19-tetrol (1) and ent-kaurane-16beta,17,18,19-tetrol (2), were isolated from the extract, together with six known compounds. The structures of the new compounds were determined on the basis of chemical and physicochemical evidence. PMID: 20013471 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105461 Sat, 19 Dec 2009 18:28:26 +0100 3105461 http://www.medworm.com/index.php?rid=3105460&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013472%26dopt%3DAbstract Authors: Orav A, Raal A, Arak E Variations in the essential oil composition of Chamomilla recutita (L.) Rauschert from different European countries were determined. A total of 39 components were identified, representing over 92% of the total oil yield. The principal biologically active compounds in chamomile oils were bisabolol oxide A (3.1-56.0%), alpha-bisabolol (0.1-44.2%), bisabolol oxide B (3.9-27.2%), cis-enyne-bicycloether (8.8-26.1%), bisabolon oxide A (0.5-24.8%), chamazulene (0.7-15.3%), spathulenol (1.7-4.8%) and (E)-beta-farnesene (2.3-6.6%). In 8 chamomile samples from 13, bisabolol oxide A (27.5-56.0%) was predominant (among them in three Estonian samples). alpha-Bisabolol (23.9-44.2%) was predominant in the samples from Moldova, Russia and the Czech Republic. The sample ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105460 Sat, 19 Dec 2009 18:28:24 +0100 3105460 http://www.medworm.com/index.php?rid=3105459&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013473%26dopt%3DAbstract Authors: Sarı A A phytochemical investigation of Scorzonera veratrifolia Fenzl (Asteraceae) yielded two new 3-benzylphthalides, scorzoveratrin (1) and scorzoveratrozit (2), together with five known compounds, chlorogenic acid (3), chlorogenic acid methyl ester (4), cryptochlorogenic acid (5), 4,5-dicaffeoylquinic acid (6) and 3,5-dicaffeoylquinic acid (7). All secondary metabolites were assigned using physicochemical and spectroscopic data. The known compounds 3-7 were isolated for the first time from this species. PMID: 20013473 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105459 Sat, 19 Dec 2009 18:28:21 +0100 3105459 http://www.medworm.com/index.php?rid=3105458&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013474%26dopt%3DAbstract Authors: Singh S, Singh TD, Singh VP, Pandey VB A new benzylisoquinoline alkaloid, argemexirine, together with two known protoberberine alkaloids, dl-tetrahydrocoptisine and dihydrocoptisine, have been isolated from the methanolic extract of the whole plant of Argemone mexicana L. The compounds were identified by spectral and chemical evidence. This is the first report of these alkaloids in this plant species. PMID: 20013474 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105458 Sat, 19 Dec 2009 18:28:19 +0100 3105458 http://www.medworm.com/index.php?rid=3105457&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013475%26dopt%3DAbstract Authors: Nagashima F, Kuba Y, Ogata A, Asakawa Y Two new sesquiterpenoids, 1 and 2, were isolated from the unidentified liverwort Gackstroemia species, and three known sesquiterpenoids, 3-5, and a known sesqui- (6) and diterpenoid (7) were isolated from Bazzania novae-zelandiae and the unidentified Dendromastigophora species, respectively. Their structures were determined by spectroscopic analysis. PMID: 20013475 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105457 Sat, 19 Dec 2009 18:28:16 +0100 3105457 http://www.medworm.com/index.php?rid=3105456&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013476%26dopt%3DAbstract Authors: Siddiqui BS, Khan S, Nadeem Kardar M A new isoflavone, 3',4'-dihydroxy-5,2'-dimethoxy-6,7-methylendioxy isoflavone, was isolated from the Madhuca latifolia fruit coatings. The structure was elucidated on the basis of spectral and chemical evidence. PMID: 20013476 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105456 Sat, 19 Dec 2009 18:28:14 +0100 3105456 http://www.medworm.com/index.php?rid=3105455&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013477%26dopt%3DAbstract Authors: Shao C, Wang C, Zheng C, She Z, Gu Y, Lin Y A new anthraquinone compound, 5-acetyl-2-methoxy-1,4,6-trihydroxy-anthraquinone (1), together with four known naphthoquinones (2-5), were isolated from the culture of the mangrove fungus (No. b77). All the isolated compounds (1-5) and the acetyl derivative (1a) were established by comprehensive analysis of the spectral data, especially 1D- and 2D-NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 showed strong inhibitory effects on the growth of hepG2 and hep2 cells, with IC(50) values of 1.0 and 2.5 microg mL(-1), respectively. PMID: 20013477 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105455 Sat, 19 Dec 2009 18:28:11 +0100 3105455 http://www.medworm.com/index.php?rid=3105454&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013478%26dopt%3DAbstract Authors: Guo Z, Zou K, Dan F, Wang J, Zhu S, Komatsu K Panajaponin, a new glycosphingolipid compound (1), together with eight known compounds, 28-glu-oleanolic acid ester (2), chikusetsusaponin IVa (3), chikusetsusaponin IV (4), ginsenoside Ro (5), ginsenoside Re (6), notoginsenoside R2 (7), ginsenoside Rg2 (8) and adenosine (9), was isolated from Panax japonicus, and the structures of all of the compounds were established on the basis of NMR and MS spectra. PMID: 20013478 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105454 Sat, 19 Dec 2009 18:28:09 +0100 3105454 http://www.medworm.com/index.php?rid=3105453&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20013479%26dopt%3DAbstract Authors: Kizil S, Turk M Sumac (Rhus coriaria L.) and terebinth (Pistacia terebinthus L.) are two important spice plants of south eastern Anatolia, Turkey. Nutrients, physical properties including moisture, ash, dry matter, protein, fatty oil and essential oil content, along with Al, Ca, Cd, Cr, Cu, Fe, K, Mg, Na, Ni, Pb, Zn and characteristics of fruit sizes and fatty acid compositions of both plants were determined from ripe fruits. The free fatty acid content was determined in the fruit oil, and the main fatty acids of sumac and terebinth were identified by gas chromatography/mass spectrometry. They included oleic, linoleic, palmitic and stearic acids in a ratio of 37.7% and 34.8%, 27.4% and 17.3%, 21.1% and 21.7% and, 4.7% and 2.5%, respectively. The fruits of both plants were rich... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3105453 Sat, 19 Dec 2009 18:28:06 +0100 3105453 http://www.medworm.com/index.php?rid=3008992&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19921583%26dopt%3DAbstract Authors: Dey S, Deepak M, Setty M, D'Souza P, Agarwal A, Sangli GK Thin layer chromatography bioautography (using DPPH spray reagent) guided fractionation of Glycyrrhiza glabra led to the isolation of two caffeic acid derivative esters, viz. eicosanyl caffeate (1) and docosyl caffeate (2). The two compounds exhibited potent elastase inhibitory activity, with IC(50) values of 0.99 microg mL(-1) and 1.4 microg mL(-1) for 1 and 2, respectively. The compounds also showed moderate antioxidant activity in DPPH and ABTS scavenging assays. The results indicate a possible role of caffeic acid derivatives, in addition to flavonoids in the anti-ulcer properties of G. glabra. PMID: 19921583 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3008992 Fri, 20 Nov 2009 03:00:30 +0100 3008992 http://www.medworm.com/index.php?rid=3008991&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19921584%26dopt%3DAbstract Authors: Manzo E, Ciavatta ML, Gavagnin M, Villani G, Quaranta C, D'Souza L, Cimino G Chemical investigation of the liposoluble extract of the gorgonian Acanthogorgia turgida, from Indian coasts, led us to isolate a new xenicane-based norditerpene, isoacalycixeniolide-A (1), along with the known structurally related compounds 2-6. The structure of the norditerpene (1) was elucidated by spectral methods (mainly by NMR techniques), whereas the absolute stereochemistry was suggested by the application of circular dicroism methodology. PMID: 19921584 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3008991 Fri, 20 Nov 2009 03:00:27 +0100 3008991 http://www.medworm.com/index.php?rid=3008990&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19921585%26dopt%3DAbstract Authors: Raj K, Sharma M, Misra N A novel terpenoid coumarin, clausmarin-C (1), has been isolated from Clausena pentaphylla. Its structure has been established by extensive 1D- and 2D-NMR analysis and chemical transformation. PMID: 19921585 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3008990 Fri, 20 Nov 2009 03:00:24 +0100 3008990 http://www.medworm.com/index.php?rid=3008989&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19921586%26dopt%3DAbstract Authors: Fontenele JB, Leal LK, Felix FH, Silveira ER, Viana GS The acute anti-inflammatory properties of a fraction rich in the chalcones lonchocarpin and derricin, from the roots of Lonchocarpus sericeus (HFLS), were studied for the first time, using a paw oedema model induced in rats by various stimuli. Results showed that HFLS (100 and 200 mg kg(-1), i.p.) was ineffective in inhibiting dextran-induced paw oedema. The HFLS (200 mg kg(-1), p.o. or i.p.) also failed to inhibit the bradykinin-induced oedema. In the yeast-elicited oedema, the HFLS (200 mg kg(-1), i.p.) caused inhibitions ranging from 42 to 59% in the first to fourth hours. Orally administered HFLS (200 mg kg(-1)) was active only in the second (27%) and fourth (32%) hours after yeast injection. It was observed that HFLS ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3008989 Fri, 20 Nov 2009 03:00:21 +0100 3008989 http://www.medworm.com/index.php?rid=3008988&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19921587%26dopt%3DAbstract Authors: Xu YJ, Zhao DX, Fu CX, Cheng LQ, Wang NF, Han LJ, Ma FS Saussurea involucrata produces several bioactive flavonoids that are derived from the phenylpropanoid pathway. To determine these flavonoids, a sensitive high performance liquid chromatography electrospray ionisation mass spectrometry method (LC-ESI-MS) was developed. Chromatographic separation was then performed. The gradient elution was optimised to give high recoveries and satisfactory chromatographic resolution. Flavonoid detection was carried out using an ion trap as mass analyser. Parameters of the mass analyser were optimised. We used the validated LC-ESI-MS method to verify the identities of bioactive compounds, namely apigenin, luteolin, hispidulin, luteolin-7-O-glucoside and rutin. Calibration curves for these f... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3008988 Fri, 20 Nov 2009 03:00:19 +0100 3008988 http://www.medworm.com/index.php?rid=3008987&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19921588%26dopt%3DAbstract In this study, we investigated the effect of triptolide on the CD4+ and CD8+ cell distribution in Peyer's patch cells and periphery lymphocytes and TGF-beta and IFN-gamma levels in periphery in collagen induced arthritis (CIA) in DA rats. CIA in the rat is a widely studied animal model of inflammatory polyarthritis, with similarities to RA, and the DA rat is one of most susceptible strains for CIA. Our data show that triptolide could lower the arthritic scores of CIA. The more CD8+ cells in the Peyer's patch, the more CD4+ cells in periphery. High level IFN-gamma and low level TGF-beta in periphery are observed in CIA rats, while the less CD4+ and CD8+ cells in the Peyer's patch, the less CD4+ cells in periphery. Low level IFN-gamma and high level TGF-beta in periphery are shown in triptol... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3008987 Fri, 20 Nov 2009 03:00:16 +0100 3008987 http://www.medworm.com/index.php?rid=3008986&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19921589%26dopt%3DAbstract This study is aimed to evaluate the in vitro cytotoxicity of Senecio stabianus Lacaita (Asteraceae) against renal adenocarcinoma ACHN, hormone-dependent prostate carcinoma LNCaP, amelanotic melanoma C32 and human breast adenocarcinoma MCF-7 cell lines. The n-hexane extract showed an interesting activity with IC(50) values of 62.7 and 71.1 mug mL(-1) against C32 and LNCaP, respectively. Two compounds identified in the n-hexane extract, linalool and beta-caryophyllene, were found to be active against C32 cells (IC(50) values of 23.2 and 20.1 mug mL(-1), respectively). Among tested constituents, the highest activity was found when alpha-humulene was applied to LNCaP cells (IC(50) of 11.2 mug mL(-1)). In order to complete the phytochemical study on S. stabianus, which has not been investigated... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3008986 Fri, 20 Nov 2009 03:00:14 +0100 3008986 http://www.medworm.com/index.php?rid=3008985&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19921590%26dopt%3DAbstract Authors: Begum S, Choudhary MI, Khan KM Fourteen N,N'-diaryl unsymmetrically substituted thioureas were synthesised and their cytotoxic (in vitro), phytotoxic (in vitro), acetylcholinesterase and butrylcholinesterase activities were determined. Thiourea 16 exhibited high, and 1 and 3 showed significant phytotoxic activity. Thioureas 1, 3, 4, 6 and 10 showed significant activity and 2, 6 and 7 indicated moderate cytotoxic activities. Compound 12 exhibited butrylcholinesterase activity higher than a standard reference. PMID: 19921590 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3008985 Fri, 20 Nov 2009 03:00:11 +0100 3008985 http://www.medworm.com/index.php?rid=3008984&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19921591%26dopt%3DAbstract Authors: Savikin K, Zdunic G, Jankovic T, Stanojkovic T, Juranic Z, Menkovic N Cytotoxicity and antioxidant properties of the methanol extracts of leaves and flowers of Cornus mas and Cotinus coggygria were studied, together with their chemical composition. Extracts of C. coggygria flowers and leaves showed better antioxidant activity in reaction with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical as well as in inhibition of lipid peroxidation (LP) than C. mas extracts. Preliminary results showed that all extracts possessed potential cytotoxic activity towards HeLa and LS174 human cancer cell lines in vitro, with stronger inhibition against growth of HeLa cell growth than against LS174 cell growth. Cytotoxic activity of C. coggygria extracts showed good correlation with their antioxidati... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3008984 Fri, 20 Nov 2009 03:00:08 +0100 3008984 http://www.medworm.com/index.php?rid=3008983&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19921592%26dopt%3DAbstract Authors: Siddiqui BS, Uddin N, Begum S From the aerial parts of Lawsonia alba two new dioxin derivatives, namely 12-[2'-(1', 4'-dioxin-5', 6'-dione)-8''E-undecenyl-dodecanoate (1) and 5-[1'-(docosa-2'E, 5'E-dienyl)]-1,4-dioxin-2,3-dione (2), were isolated and characterised on the basis of spectroscopic methods. PMID: 19921592 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=3008983 Fri, 20 Nov 2009 03:00:06 +0100 3008983 http://www.medworm.com/index.php?rid=2924006&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851921%26dopt%3DAbstract Authors: Miyazawa M, Shirakawa N, Utsunomiya H, Inada K, Yamada T The composition of the volatile components from unripe (I) and ripe (II) Japanese apricot (Prunus mume Sieb. et Zucc.) have been investigated. Seventy-six volatile components were identified, 25 for the first time as volatile constituents of Japanese apricot. The main components were benzaldehyde (I, 59.16%; II, 1.81%), isolongifololyl acetate (II, 19.21%), palmitic acid (I, trace; 10.22%), linalool (I, 9.93%; II, 7.34%), and butyl acetate (II, 8.30%). Unripe Japanese apricot have a green colour due to the main components being aldehydes. On the contrary, ripe Japanese apricot had a fruity note due to the increase of the ratio of esters during ripening. PMID: 19851921 [PubMed - in process] (Source: Natural Product Re... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2924006 Sun, 25 Oct 2009 05:22:02 +0100 2924006 http://www.medworm.com/index.php?rid=2924005&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851922%26dopt%3DAbstract Authors: Shao C, Wang C, Li C, She Z, Gu Y, Lin Y A new sesquiterpenoid compound, microsphaeropsisin A (1), together with three known dihydroisocoumarin compounds, (R)-mellein (2), 4-hydroxymellein (3) and 5-hydroxymellein (4) were isolated from the culture of the mangrove fungus (No. DZ39). The structure of the new compound was established by comprehensive spectral analysis, especially 2D NMR spectroscopy. PMID: 19851922 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2924005 Sun, 25 Oct 2009 05:22:02 +0100 2924005 http://www.medworm.com/index.php?rid=2924004&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851923%26dopt%3DAbstract Authors: Iranshahi M, Noroozi S, Behravan J, Karimi G, Schneider B A new sulphur-containing compound, persicasulphide C, was isolated from the roots of Ferula persica, and its structure was characterised by 1D- and 2D-NMR spectroscopy as well as HRMS. In addition, closer inspection of NMR spectra of the previously reported polysulphides (persicasulphides A and B) revealed that their structures are slightly different from those reported. In this article, the correct structures of persicasulphides A and B are also presented. PMID: 19851923 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2924004 Sun, 25 Oct 2009 05:22:02 +0100 2924004 http://www.medworm.com/index.php?rid=2924003&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851924%26dopt%3DAbstract Authors: Qin C, Li Y, Zhang R, Niu W, Ding Y Anthocyanin pigments in the fruit of mockstrawberry (Duchesnea indica Focke), were extracted with 0.1% HCl in ethanol, and the crude anthocyanin extract was purified by a C18 Sep-Pak cartridge open-column chromatography. High-performance liquid chromatography (HPLC) with photodiode array detection and mass spectrometry (MS) was applied for the isolation and composition analysis of anthocyanins in the fruit of mockstrawberry and their aglycones from acid hydrolysis. Three anthocyanins were found in the fruit of mockstrawberry and they were identified as cyanidin 3-O-rutinoside (61%), peonidin 3-O-rutinoside (34%), and petunidin 3-O-rutinoside (5%), respectively, by spectroscopic methods (UV-vis and MS). The two major anthocyanins were isolate... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2924003 Sun, 25 Oct 2009 05:22:02 +0100 2924003 http://www.medworm.com/index.php?rid=2924002&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851925%26dopt%3DAbstract Authors: Jain L, Pandey MB, Singh S, Singh AK, Pandey VB A new indole alkaloid, N-formylscholarine, together with picrinine, strictamine and nareline has been isolated from the fruit pods of Alstonia scholaris, and their structures were established by various spectral data. This is the first report of these alkaloids in A. scholaris fruit pods. PMID: 19851925 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2924002 Sun, 25 Oct 2009 05:22:02 +0100 2924002 http://www.medworm.com/index.php?rid=2924001&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851926%26dopt%3DAbstract Authors: Siddiqui BS, Khatoon N, Begum S, Durrani SA Two new triterpenoid isomers alpha-neriursate (1) and beta-neriursate (2) have been isolated from the fresh, uncrushed leaves of Nerium oleander and their structures elucidated as 3alpha-acetophenoxy-urs-12-en-28-oic acid and 3beta-acetophenoxy-urs-12-en-28-oic acid, respectively. The structure elucidation is based on spectroscopic methods, including 1D ((1)H NMR, (13)C NMR) and 2D ((1)H-(1)H COSY, NOESY, HMQC, HMBC and J-resolved) NMR data and chemical transformation. PMID: 19851926 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2924001 Sun, 25 Oct 2009 05:22:02 +0100 2924001 http://www.medworm.com/index.php?rid=2924000&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851927%26dopt%3DAbstract Authors: Gohari AR, Saeidnia S, Gohari MR, Moradi-Afrapoli F, Malmir M, Hadjiakhoondi A From the ethyl acetate and methanol extract of the aerial parts of Satureja atropatana Bonge, which belongs to the Lamiaceae family, four flavonoids were isolated. Their structures were determined to be 5,6,3'-trihydroxy-7,8,4'-trimethoxyflavone (1), 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone or 5-desmethoxynobiletin (2), 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone or thymonin (3) and luteolin (4) using (1)H and (13)C-NMR and MS spectra. Brine shrimp cytotoxicity effects of the crude extracts and isolated compounds were examined. Berberine hydrochloride (LC(50) = 26 microg mL(-1)) was used as a positive control. Among them, compounds 2 (199 microg mL(-1)) and 3 (157 microg mL(-1)) were effective aga... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2924000 Sun, 25 Oct 2009 05:22:02 +0100 2924000 http://www.medworm.com/index.php?rid=2923999&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851928%26dopt%3DAbstract Authors: Brochini CB, Roque NF, Lago JH The essential oil from leaves of Guarea guidonia was subjected to chromatographic separation procedures to afford nine sesquiterpenes; two of them are new eudesmane derivatives. The chemical structures of the obtained compounds were characterised by spectrometric analysis, mainly mass spectrometry and NMR. PMID: 19851928 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2923999 Sun, 25 Oct 2009 05:22:02 +0100 2923999 http://www.medworm.com/index.php?rid=2923998&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851929%26dopt%3DAbstract Authors: Hilal Y, Engelhardt UH The isolation and structural elucidation of the novel myricetin-3-O-[beta-D-glucopyranosyl-(1 --> 3)-alpha-L-rhamnopyranosyl-(1 --> 6)-beta-D-glucopyranoside] from tea (Camellia sinensis (L.) O. Kuntze) by means of HPLC-MS/MS and various NMR techniques is described. The compound was not present in all tea samples analysed. In the case of white tea, it was detected in 20 out of 40 samples analysed (35-255 mg kg(-1)), in green tea it was detected in 18 out of 35 samples in the same concentration range (37-205 mg kg(-1)), while it was found only in 1 sample (51 mg kg(-1)) of 5 black teas analysed. PMID: 19851929 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2923998 Sun, 25 Oct 2009 05:22:02 +0100 2923998 http://www.medworm.com/index.php?rid=2923997&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851930%26dopt%3DAbstract This study evaluates the presence, location and production source of tetrodotoxin (TTX) in two species of pufferfish, Diodon histrix and Arothron hispidus, common to Hawaiian waters. Organs from each fish were analysed for TTX and used to isolate bacteria for evaluation of possible TTX production. Comparative analyses of extracts of fish and bacterial culture media were performed with liquid chromatography-mass spectrometry (LC-MS) and a sodium channel specific bioassay. Bacterial cultivation experiments were performed in two different growth media and bacteria were identified through sequence homology of the 16S rRNA gene. Forty-two and forty-seven distinct strains were cultivated from D. histrix and A. hispidus, respectively. However, no commonality was found between the populations of b... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2923997 Sun, 25 Oct 2009 05:22:02 +0100 2923997 http://www.medworm.com/index.php?rid=2923996&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851931%26dopt%3DAbstract Authors: Zhang J, Wang FX, Liu ZW, Zhang ST, Zhang YY, Liang JY, Wang YP In this article, the structural properties of Cynomorium songaricum Rupr. polysaccharide (CSP) after selenylation were investigated. The crude polysaccharide was obtained from C. songaricum Rupr. by water extraction followed by ethanol precipitation and freeze vacuum drying. Then selenylation of CSP has been accomplished by employing sodium selenite to modify the polysaccharide under the catalysis of nitric acid-barium chloride. After selenylation, the sugar content and the molecular weight increased but the protein content reduced. The maximum selenic content determined by ICP-AES was 2925 microg g(-1). The selenide CSP (Se-CSP) was characterised by the methods of UV spectra, FT-IR, Raman spectra and X-ray photoe... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2923996 Sun, 25 Oct 2009 05:22:02 +0100 2923996 http://www.medworm.com/index.php?rid=2923995&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19851932%26dopt%3DAbstract Authors: Shankar T, Muthusubramanian S, Gandhidasan R From the stem of Derris ovalifolia, a new chromanone alkaloid characterised as 7-methoxy-3-[1-(3-pyridyl)methylidene]-4-chromanone (1) was isolated along with four known compounds, dehydrotoxicarol (2), dehydrodeguelin (3), toxicarol isoflavone (4) and indole-3-carbaldehyde (5). Their structures were determined on the basis of spectral data interpretation. The structure of compound 1 has also been confirmed by synthesis. PMID: 19851932 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2923995 Sun, 25 Oct 2009 05:22:02 +0100 2923995 http://www.medworm.com/index.php?rid=2917044&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19844820%26dopt%3DAbstract Authors: Hammami S, Mighri N, Ben Jannet H, Boughalleb N, Zardi-Bergaoui A, Nefzi A, Abreu P, Mighri Z Bioactivity guided fractionation of Echiochilon fruticosum Desf. (Boraginaceae) butanolic extract biautography assay against fungi led to the isolation of a new bioactive alkaloid, named saoussanabiloide (1). Its structure was established on the basis of spectroscopic measurements, IR, MS and 2D NMR using COSY, HMQC and HMBC experiments. The strongest inhibitory effect of the butanolic extract, from fractions derived from the crude extract and saoussanabiloide (1), were observed against Fusarium oxysporum f. sp. niveum. PMID: 19844820 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2917044 Fri, 23 Oct 2009 08:52:07 +0100 2917044 http://www.medworm.com/index.php?rid=2917043&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19844821%26dopt%3DAbstract Authors: Saisin S, Tip-Pyang S, Phuwapraisirisan P A new flavonoid, named 5,7,2'-trihydroxy-5'-methoxyflavone (1), was isolated from the acetone extract of the lianas of Gnetum macrostachyum together with 5,7,4'-trihydroxy-3'-methoxyflavanone (2) and seven known stilbenoids (3-7). The structure of the new compound was determined by interpretation of its spectral data and chemical transformation. The isolated compounds showed radical scavenging activity against DPPH with IC(50) values in the range of 0.21-19.90 mM. PMID: 19844821 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2917043 Fri, 23 Oct 2009 08:52:07 +0100 2917043 http://www.medworm.com/index.php?rid=2917042&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19844822%26dopt%3DAbstract Authors: Cabral C, Goncalves MJ, Cavaleiro C, Sales F, Boyom F, Salgueiro L The chemical composition of the essential oils obtained by hydrodistillation from the aerial parts of two populations of Vitex rivularis (subgenus Vitex) collected during the flowering phase of the plants was investigated by gas chromatography and gas chromatography/mass spectroscopy. Sesquiterpene hydrocarbons were the main group in both samples, the main compound being germacrene D. This composition is markedly different from that of the other African species, with the exception of Vitex ferruginea subsp. amboniensis, which belongs to the same subgenus as V. rivularis. Minimal inhibitory concentrations (MIC) and minimal lethal concentrations (MLC) were used to evaluate the anti-fungal activity against yeasts ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2917042 Fri, 23 Oct 2009 08:52:07 +0100 2917042 http://www.medworm.com/index.php?rid=2917041&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19844823%26dopt%3DAbstract Authors: Gonzalez MA, Correa-Royero J, Mesa A, Betancur-Galvis L The synthesis of the marine natural products pyridinebetaine A and B is reported. The biological evaluation of pyridinebetaine A and B and several analogues as cytotoxic, antifungal and antiviral agents is also described. Unfortunately, none of the compounds tested showed relevant antifungal or cytotoxic activity. Only pyridinebetaine B reduced the Herpes simplex virus type 1 virus replication, though only weakly. PMID: 19844823 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2917041 Fri, 23 Oct 2009 08:52:07 +0100 2917041 http://www.medworm.com/index.php?rid=2917040&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19844824%26dopt%3DAbstract Authors: Thirugnanasampandan R, Jayakumar R Isodon wightii is a common plant found in the Western Ghats of South India. The ent-kaurene diterpenoid melissoidesin, isolated from the leaves of I. wightii, showed significant cytotoxicity against lung cancer and neuroblastoma cell lines with IC(50) values of 6 and 4.2 microg mL(-1), respectively. The prevention of deoxyribose degradation activity of melissoidesin was significant and the IC(50) value was calculated to be 163.1 microg mL(-1). The anticarcinogenic activity of melissoidesin by comet assay showed significant DNA damage protecting activity in a dose-dependent manner. PMID: 19844824 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2917040 Fri, 23 Oct 2009 08:52:07 +0100 2917040 http://www.medworm.com/index.php?rid=2917039&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19844825%26dopt%3DAbstract Authors: Olszewska MA, Michel P The antioxidant potential of 70% methanolic extracts from the inflorescences, leaves and fruits of Sorbus aucuparia, S. aria and S. intermedia was evaluated using three in vitro test systems (DPPH: 2,2-diphenyl-1-picryl hydrazyl; TEAC: trolox equivalent antioxidant capacity and FRAP: ferric reducing/antioxidant power). High activities found were expressed as micromoles trolox equivalents per gram dry weight and were in the range of 86.9-956.2 for the DPPH test, 65.3-577.2 for the TEAC assay and 221.1-1915.2 for the FRAP method. Significant linear correlations (R(2) in the range of 0.75-0.98) between these values and the contents of total phenolics, total flavonoids, total proanthocyanidins and chlorogenic acid isomers showed that the listed phenolic comp... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2917039 Fri, 23 Oct 2009 08:52:07 +0100 2917039 http://www.medworm.com/index.php?rid=2917038&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19844826%26dopt%3DAbstract Authors: Razavi SM, Zahri S, Nazemiyeh H, Zarrini G, Mohammadi S, Abolghassemi-Fakhri MA A known furanocoumarin, 8-geranyloxy psoralen, was isolated from n-hexane extract of Prangos uloptera roots by the TLC method. Its structure was determined by comparison of the spectral data with the literature. Cytotoxic effects of the isolated compound were determined by MTT and Tripan blue assays. The antioxidant and antimicrobial potential of the compound were evaluated by DPPH assay and agar dilution method, respectively. The MTT assay results showed that 8-geranyloxy psoralen reduced cell viability of Hela and Mc-Coy cell lines with IC(50) values of 0.792 and 0.835 mM, respectively. Based on the Tripan blue asay, the compound has cytotoxic effects, with an IC(50) value of 1.26 mM for Mc-Coy c... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2917038 Fri, 23 Oct 2009 08:52:07 +0100 2917038 http://www.medworm.com/index.php?rid=2917037&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19844827%26dopt%3DAbstract Authors: Javaid A, Adrees H In the present study, herbicidal activity of culture filtrates of nine phytopathogenic fungi, namely, Alternaria alternata (Fr.) Keissl., Drechslera australiensis (Bugnicourt) Subramanian & Jain, Drechslera hawaiiensis (Curtis and Cooke) Shoemaker, Drechslera biseptata (Saccardo & Roumeguere) Richardson & Fraser., Drechslera rostrata (Drechsler) Ricardson & Fraser, Fusarium oxysporum (Massey) Synd. & Hans., Fusarium solani (Martius) Saccardo., Monilia stophila (Montagne) and Cladosporium sp. (Grey) de Hoff, was evaluated against parthenium weed (Parthenium hysterophorus L.). In laboratory bioassays, the effect of original (100%) as well as lower concentrations (75, 50 and 25%) of these cultural filtrates was studied on germination and ear... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2917037 Fri, 23 Oct 2009 08:52:07 +0100 2917037 http://www.medworm.com/index.php?rid=2917036&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19844828%26dopt%3DAbstract Authors: Bachiega TF, Orsatti CL, Pagliarone AC, Missima F, Sousa JP, Bastos JK, Sforcin JM Although clove possesses several biological and therapeutic properties, its immunomodulatory action has not been fully investigated. The goal of this work was to investigate the effect of administration of the water extract of clove over a short-term to BALB/c mice on Th1 (IFN-gamma and IL-2) and Th2 (IL-4 and IL-10) cytokine production. After treatment, spleen cells were aseptically removed and cells were stimulated with concanavalin A. Supernatants of cell cultures were used for cytokine determination by ELISA. The chemical composition of the extract was also carried out, revealing that eugenol(4-allyl-2-methoxyphenol) was the major component in our sample. Although the anti-inflammatory actio... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2917036 Fri, 23 Oct 2009 08:52:07 +0100 2917036 http://www.medworm.com/index.php?rid=2917035&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19844829%26dopt%3DAbstract Authors: Aguilar-Guadarrama B, Navarro V, Leon-Rivera I, Rios MY Secondary metabolites 5-acetyl-3beta-angeloyloxy-2beta-(1-hydroxyisopropyl)-2,3-dihydrobenzofurane (1), 5-acetyl-3beta-angeloyloxy-2beta-(1-hydroxyisopropyl)-6-methoxy-2,3-dihydrobenzofurane (2), espeletone (3), encecalinol (4), O-methylencecalinol (5), encecalin (6), sonorol (7), taraxerol (8), (+)-beta-eudesmol (9), and a mixture of beta-sitosterol and stigmasterol, were isolated from the aerial parts of Ageratina pichinchensis var. bustamenta. The antimicrobial activity of compounds 6, 8 and 9, together with derivatives 9a and 9b against the most important dermatophytes responsible for tinea pedis infection, Trichophyton rubrum and T. mentagrophytes, and against Candida albicans and Aspergillus niger were determined, s... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2917035 Fri, 23 Oct 2009 08:52:07 +0100 2917035 http://www.medworm.com/index.php?rid=2870555&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809906%26dopt%3DAbstract Authors: Wang HB, Tan CH, Tan JJ, Qu SJ, Chen YL, Li YM, Jiang SH, Zhu DY Two new Lycopodium alkaloids, N-oxidehuperzine E (1) and N-oxidehuperzine F (2), along with two known alkaloids, huperzines E (3) and F (4), were isolated from Huperzia serrata (Thunb.) Trev. Their structures were elucidated by spectroscopic and chemical transformations. PMID: 19809906 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870555 Thu, 08 Oct 2009 10:02:04 +0100 2870555 http://www.medworm.com/index.php?rid=2870554&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809907%26dopt%3DAbstract Authors: Falchero L, Coppa M, Fossi A, Lombardi G, Ramella D, Tava A The volatile fraction from the aerial part of Alchemilla xanthochlora Rothm. (Rosaceae) was obtained by hydrodistillation, and the chemical composition of the obtained oil was determined by GC/FID and GC/MS. Several compounds were found, belonging to the classes of aldehydes, alcohols, terpenes, esters, acids and hydrocarbons. The major constituents were cis-3-hexenol (11.20+/-0.02%), linalool (10.36+/-0.75%), oct-1-en-3-ol (8.98+/-1.43%), and nonanal (7.83+/-0.93%), followed by myrtenol (4.65+/-0.40%), hexadecanoic acid (4.59+/-0.79%), cis-3-hexenyl acetate (3.92+/-0.15%) and alpha-terpineol (3.10+/-0.26%). PMID: 19809907 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870554 Thu, 08 Oct 2009 10:02:04 +0100 2870554 http://www.medworm.com/index.php?rid=2870553&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809908%26dopt%3DAbstract Authors: Abou-Zaid MM, Lombardo DA, Nozzolillo C Methyl gallate was found in ethanolic extracts of red maple (Acer rubrum L.), silver maple (A. saccharinum L.) and sugar maple (A. saccharum Marsh) leaves, but more was present in methanolic extracts. The increased amount of methyl gallate in methanolic extracts was accompanied by a disappearance of m-digallate. It is concluded that only some of the methyl gallate detected in methanolic extracts is an artefact as a result of methanolysis of m-digallate. Its presence in ethanolic extracts is evidence that it is also a natural constituent of maple leaves. PMID: 19809908 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870553 Thu, 08 Oct 2009 10:02:04 +0100 2870553 http://www.medworm.com/index.php?rid=2870552&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809909%26dopt%3DAbstract Authors: Li J, Jiang H, Shi R A new acylated quercetin glycoside quercetin-3-O-(4'''-O-trans-caffeoyl)-alpha-L-rhamnopyranosyl-(1-->6)-beta-D-galacopyranoside (1), along with luteolin (2), quercetin (3), luteolin-7-O-beta-D-glucoside (4), apigenin-7-O-beta-D-glucoside (5), quercitrin (6), quercetin-3-O-beta-D-arabinoside (7) and 4,5-di-O-caffeoyl quinic acid (8) have been isolated from the leaves of Stevia rebaudiana Bertoni. The structures of these compounds were determined by spectroscopic methods (1H- and 13C-NMR, IR and MS) and by 2D-NMR experiments. PMID: 19809909 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870552 Thu, 08 Oct 2009 10:02:04 +0100 2870552 http://www.medworm.com/index.php?rid=2870551&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809910%26dopt%3DAbstract Authors: Rajkapoor B, Murugesh N, Rama Krishna D A flavanone has been isolated first time from the stem of Bauhinia variegata, and its structure was identified by colour reactions and spectral analysis. In a search for novel anticancer compounds from medicinal plants, the isolated flavanone was tested for cytotoxic activity against 57 human tumour lines, representing leukaemia, non-small cell lung, colon, central nervous system, melanoma, ovarian, renal, prostate and breast cancers. The results showed that the flavanone has cytotoxic activity against human tumour cell lines. PMID: 19809910 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870551 Thu, 08 Oct 2009 10:02:04 +0100 2870551 http://www.medworm.com/index.php?rid=2870550&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809911%26dopt%3DAbstract Authors: Liu C, Zhang S, Wu H Schisandra chinensis (Turcz.) Baill has been used as a traditional Chinese medicine in China and Japan. It has been used as an anti-aging drug, a stimulant, a sedative and a tonic drug. Its active components are lignans, including deoxyschisandrin, gamma-schisandrin, schizandrin, gomisin A, and so on. Both deoxyschisandrin and gamma-schisandrin were proved to have the effect of protection against CCl4-induced hepatic damage. The extraction of deoxyschisandrin and gamma-schisandrin from S. chinensis using classical methods, however, are tedious and time consuming. So, ultrahigh pressure extraction (UHPE) was used to extract deoxyschisandrin and gamma-schisandrin from S. chinensis. At the same time, heat reflux and ultrasonic extraction methods were chosen a... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870550 Thu, 08 Oct 2009 10:02:04 +0100 2870550 http://www.medworm.com/index.php?rid=2870549&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809912%26dopt%3DAbstract Authors: Zhang Q, Ji Z, Wang M, Wu W Two new insecticidal sesquiterpene esters with a beta-dihydroagarofuran sesquiterpene skeleton, ejaponine A (1) and ejaponine B (2), and two known compounds, 3 and 4, were isolated from the EtOAc extract of the root bark of Euonymus japonicus Thunb. by bioassay-guided fractionation. Their chemical structures were elucidated mainly by analysis of MS and NMR spectral data. The LD50 values of ejaponine A (1), ejaponine B (2), 3 and 4 showed against Mythimna separata were 89.2, 98.6, 181.4 and 109.2 microg g(-1), respectively. PMID: 19809912 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870549 Thu, 08 Oct 2009 10:02:04 +0100 2870549 http://www.medworm.com/index.php?rid=2870545&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809913%26dopt%3DAbstract Authors: Sunghwa F, Koketsu M A new bis-iridoid glucoside, cocculoside (1), has been isolated, together with five known compounds from Strychnos cocculoides (Loganiaceae), collected in Tanzania. The structure of cocculoside (1) has been determined as an ester dimer of loganin and secologanin dimethyl acetal between C-7 and C-11. PMID: 19809913 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870545 Thu, 08 Oct 2009 10:02:04 +0100 2870545 http://www.medworm.com/index.php?rid=2870543&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809914%26dopt%3DAbstract Authors: Ee GC, Lim CM, Lim CK, Rahmani M, Shaari K, Bong CF Detailed chemical studies on the roots of Piper sarmentosum and Piper nigrum have resulted in several alkaloids. The roots of P. sarmentosum gave a new aromatic compound, 1-nitrosoimino-2,4,5-trimethoxybenzene (1). Piper nigrum roots gave pellitorine (2), (E)-1-[3',4'-(methylenedioxy)cinnamoyl]piperidine (3), 2,4-tetradecadienoic acid isobutyl amide (4), piperine (5), sylvamide (6), cepharadione A (7), piperolactam D (8) and paprazine (9). Structural elucidation of these compounds was achieved through NMR and MS techniques. Cytotoxic activity screening of the plant extracts indicated some activity. PMID: 19809914 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870543 Thu, 08 Oct 2009 10:02:04 +0100 2870543 http://www.medworm.com/index.php?rid=2870541&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809915%26dopt%3DAbstract Authors: Xing JM, Li FF A PEG6000/(NH4)2SO4 aqueous two-phase system was chosen as the separation system. The effects of NaCl, Gu(SCN)2 and pH on the partitioning of aloe polysaccharide and bovine serum albumin (BSA) were studied. The result shows that the recovery of aloe polysaccharide was decreased with the increase in pH and the recovery of protein was not changed; NaCl and Gu(SCN)2 can change the partitioning behaviour of the BSA. The separation of BSA and aloe polysaccharides was also carried out. Then, the aloe polysaccharides were obtained by using ultrafiltration membrane. The composition of the polysaccharides was analysed by gas chromatography. The results show that mannose is mainly monosaccharide, and it only contains a few glucose. PMID: 19809915 [PubMed - in process]... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870541 Thu, 08 Oct 2009 10:02:04 +0100 2870541 http://www.medworm.com/index.php?rid=2870540&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809916%26dopt%3DAbstract Authors: Li GH, Zheng LJ, Liu FF, Dang LZ, Li L, Huang R, Zhang KQ Two new cyclopentenones, trichodermone A (1) and trichodermone B (2), together with a known compound, 3-(3-oxocyclopent-1-enyl) propanoic acid (3), were isolated from the strain Trichoderma sp. YLF-3. Their structures were elucidated on the basis of their spectroscopic data. All compounds were assayed for antibacterial activity. Compound 3 showed activity against Staphyloccocus aureus and Bacillus cereus. PMID: 19809916 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870540 Thu, 08 Oct 2009 10:02:04 +0100 2870540 http://www.medworm.com/index.php?rid=2870539&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809917%26dopt%3DAbstract Authors: Wang J, Zu X, Jiang Y Two new furostanol saponins, terrestroside A, 3-O-{beta-D-xylopyranosyl-(1-->3)-[beta-D-xylopyranosyl(1-->2)]-beta-D-glucopyranosyl(1-->4)-[alpha-L-rhamnopyranosyl(1-->2)]-beta-D-galactopyranosy}-26-O-beta-D-glucopyranosyl-L-5a-furost-20(22)-en-(25R)-3beta,26-diol (1) and terrestroside B, 3-O-{beta-D-xylopyran-osyl(1-->3)-[beta-D-xylopyranosyl(1-->2)]-beta-D-glucopyranosyl(1-->4)-[alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-galactopyranosy}-26-O-beta-D-glucopyranosyl-5a-furostan-12-one-(25R)-22-methoxy-3beta,26-diol (2), together with three known compounds, chloromaloside E (3), terrestrinin B (4) and terrestroneoside A (5) were isolated from the dry fruits of Tribulus terrestris. Furthermore, the inhibitory effects of the compounds on... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870539 Thu, 08 Oct 2009 10:02:04 +0100 2870539 http://www.medworm.com/index.php?rid=2870538&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809918%26dopt%3DAbstract Authors: Bandna , Jaitak V, Kaul VK, Singh B Acylation of beta-caryophyllene, a sesquiterpene hydrocarbon with acetic anhydride, was carried out under mild catalytic conditions using Lewis acids such as BF3.Et2O, ZnCl2, FeCl3, I2 and AlCl3 as catalysts. Among these, BF3.Et2O was found to catalyse the reaction most efficiently, yielding three acylated products in 75% yield under solvent-free conditions. The structures were confirmed by NMR and MS techniques. PMID: 19809918 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870538 Thu, 08 Oct 2009 10:02:04 +0100 2870538 http://www.medworm.com/index.php?rid=2870537&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19809919%26dopt%3DAbstract Authors: Zheng RX, Xu XD, Tian Z, Yang JS Ten compounds were isolated from the fruits of Hippophae rhamnoides. On the basis of spectroscopic and chemical methods, the structures of these compounds were elucidated as hippophae cerebroside (1), oleanolic acid (2), ursolic acid (3), 19-alpha-hydroxyursolic acid (4), dulcioic acid (5), 5-hydroxymethyl-2-furancarbox-aldehyde (6), cirsiumaldehyde (7), octacosanoic acid (8), palmitic acid (9) and 1-O-hexadecanolenin (10). Among them, 1 was a new compound, and 4-7 and 10 were obtained from the genus for the first time. PMID: 19809919 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2870537 Thu, 08 Oct 2009 10:02:04 +0100 2870537 http://www.medworm.com/index.php?rid=2847134&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19787545%26dopt%3DAbstract Authors: Narasimhulu M, Ashalatha K, Sri Laxmi P, Sarma AV, Rama Rao B, Kavi Kishor PB, David Krupadanam GL, Zehra Ali A, Tiwari AK, Panneer Selvam A, Venkateswarlu Y An unusual novel and significant anti-oxidant 1,2-dibenzoyl glycoside, natansnin (1), has been isolated from Salvinia natans. The structure of 1 was established by the study of NMR and CD spectral data. PMID: 19787545 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2847134 Thu, 17 Sep 2009 23:00:00 +0100 2847134 http://www.medworm.com/index.php?rid=2810165&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19764002%26dopt%3DAbstract Authors: Zdunic G, Gođevac D, Savikin K, Novakovic M, Milosavljevic S, Petrovic S The chemical composition and free radical scavenging properties of the MeOH extract of Hypericum richeri and its subsequent CHCl(3), n-BuOH, EtOAc and aqueous extracts were investigated. Four quercetin-3-O-glycosides, three myricetin-3-O-glycosides, 3-O- and 5-O-caffeoylquinic acid, quercetin, I3,II8-biapigenin, pseudohypericin and hypericin were identified. The constituents of the extracts were quantified using HPLC-DAD (high-performance liquid chromatography-diode array detector). Isolation of the compounds from n-BuOH and EtOAc extracts was conducted by column chromatography. Antioxidant capacity of the extracts was evaluated by superoxide radical and ABTS radical(+) scavenging assays and inhibit... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2810165 Tue, 15 Sep 2009 23:00:00 +0100 2810165 http://www.medworm.com/index.php?rid=2810164&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19764003%26dopt%3DAbstract Authors: Sashidhara KV, Singh SP, Sarkar J, Sinha S The ethanolic extract of Polyalthia longifolia var. pendula was fractionated to get a hexane-soluble residue, which led to the isolation of four clerodane diterpenes: (-)-3alpha,16alpha-dihydroxycleroda-4(18),13(14)Z-dien-15,16-olide (1), (-)-3beta,16alpha-dihydroxycleroda-4(18), 13(14)Z-dien-15,16-olide (2), (-)-16alpha-hydroxycleroda-3,13(14)Z-dien-15,16-olide (3) and (-)-16-oxocleroda-3,13(14)E-dien-15-oic acid (4). Diterpene 1 is a new compound, while 2 is reported for first time from this plant. Both 1 and 2 were tested for their growth inhibitory activity on four cancer cell lines in vitro. IC(50) values suggest that they are effective as cytotoxic agents. PMID: 19764003 [PubMed - as supplied by publisher] (Source: Natural P... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2810164 Tue, 15 Sep 2009 23:00:00 +0100 2810164 http://www.medworm.com/index.php?rid=2810163&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19764004%26dopt%3DAbstract Authors: Shafique S, Bajwa R, Shafique S Aspergillus niger FCBP-198 was genetically modified for its ability to reveal extra cellular alpha-amylase enzyme activity. From 76 efficient mutants isolated after ultraviolet (UV) irradiation, An-UV-5.6 was selected as the most efficient UV mutant, with 76.41 units mL(-1) of alpha-amylase activity compared to wild (34.45 units mL(-1)). In case of ethyl methane sulphonate (EMS), among 242 survivors, 74 were assayed quantitatively and An-Ch-4.7 was found to be the most competent, as it exhibited a three-fold increase in alpha-amylase activity (89.38 units mL(-1)) than the parental strain. Genetic relationships of the mutants of A. niger FCBP-198 were analysed with a randomly amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR). Results... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2810163 Tue, 15 Sep 2009 23:00:00 +0100 2810163 http://www.medworm.com/index.php?rid=2810162&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19764005%26dopt%3DAbstract Authors: Dhanotia R, Chauhan NS, Saraf DK, Dixit VK Alopecia is a psychologically distressing phenomenon. Androgenetic alopecia (AGA) is the most common form of alopecia, which affects millions of men and women worldwide, and is an androgen driven disorder. Here, the Citrullus colocynthis Schrad fruit is evaluated for hair growth activity in androgen-induced alopecia. Petroleum ether extract of C. colocynthis was applied topically for its hair growth-promoting activity. Alopecia was induced in albino mice by testosterone administration intramuscularly for 21 days. Its inhibition by simultaneous administration of extract was evaluated using follicular density, anagen/telogen (A/T) ratio and microscopic observation of skin sections. Finasteride (5alpha-reductase inhibitor) solution was a... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2810162 Tue, 15 Sep 2009 23:00:00 +0100 2810162 http://www.medworm.com/index.php?rid=2810161&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19764006%26dopt%3DAbstract Authors: Mohamed SM, Hassan EM, Ibrahim NA Bioassay guided fractionation of the methanol extract of Magnolia grandiflora L. (Magnoliaceae) leaves led to the isolation and characterisation of four aporphine alkaloids, magnoflorine, lanuginosine, liriodenine and anonaine. The cytotoxicities of the pure compounds magnoflorine and lanuginosine were determined in a cell viability assay with the tumour cell lines Hela (cervix tumour cell line), HEPG2 (hepatocellular carcinoma cell line) and U251 (brain tumour cell line). Magnoflorine was more cytotoxic (IC(50) 0.4 microg mL(-1)) than lanuginosine (IC(50) 2.5 microg mL(-1)) against HEPG2 in comparison with the standard doxorubacin (IC(50) 0.27 microg mL(-1)). In addition, magnoflorine and lanuginosine exhibited cytotoxicity against U251, with... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2810161 Tue, 15 Sep 2009 23:00:00 +0100 2810161 http://www.medworm.com/index.php?rid=2804793&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19753500%26dopt%3DAbstract Authors: Chauhan NS, Sharma V, Dixit VK The aim of the present study was to study the effect of seeds of Asteracantha longifolia on the sexual behaviour of male albino rats. The ethanolic extract of seeds of A. longifolia was administered to groups of rats in 100, 150 and 200 mg kg(-1) doses for a period of 28 days, and the action compared with control rats. The changes in body and organ weight, sexual behaviour, histo-architecture and fructose levels of seminal vesicles were observed. The sexual behaviour was assessed by determining parameters such as mount frequency (MF), intromission latency, mount latency (ML) and post-ejaculatory latency. The ethanolic extract exhibited pronounced anabolic effects in treated animals, as evidenced by gains in the body and reproductive organ weights... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2804793 Sun, 13 Sep 2009 23:00:00 +0100 2804793 http://www.medworm.com/index.php?rid=2804792&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19753501%26dopt%3DAbstract This study was carried out in order to investigate the potential and antioxidant effects of polyphenols from Mangifera indica stem bark against gastric damage induced by ethanol and cold-restraint stress. The polyphenols possess good capacity for scavenging nitric oxide (NO) radical and ferric-reducing antioxidant power (FRAP) assay in vitro. Rats were sacrificed after the experiment, and their stomachs were removed for biochemical and histopathological analysis. The severity of lesions was found to markedly decrease by the administration of polyphenols in both models. The increased gastric nitrite level of ethanol administered rats were significantly (p < 0.001) reduced by polyphenol treatment. Administration of polyphenols reduced thiobarbituric acid reactive substance (TBARS) level a... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2804792 Sun, 13 Sep 2009 23:00:00 +0100 2804792 http://www.medworm.com/index.php?rid=2804791&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19753502%26dopt%3DAbstract Authors: Mei WL, Han Z, Cui HB, Zhao YX, Deng YY, Dai HF A new iridoid, named nudifloside (1), together with three known compounds, was isolated from the EtOH extract of the aerial parts of Callicarpa nudiflora Hook. The structures were elucidated by a study of their physical and spectral data. Nudifloside (1) and the isolated known compound linearoside (2) displayed inhibitory effects towards chronic myelogenous leukaemia K562 cell line, with IC(50) values of 20.7 and 36.0 microg mL(-1), respectively. PMID: 19753502 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2804791 Sun, 13 Sep 2009 23:00:00 +0100 2804791 http://www.medworm.com/index.php?rid=2770467&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19731133%26dopt%3DAbstract Authors: Dai Y, Zhou GX, Kurihara H, Ye WC, Yao XS Fortuneanoside F (1), a new biphenyl glycoside, together with two known phenyl glycosides: phenylmethyl O-beta-D-glucopyranoside (2) and 2-phenylethyl O-beta-D-glucopyranoside (3), was isolated from the fruit of Pyracantha fortuneana (Maxim.) Li. Its chemical structure was elucidated to be 4-hydroxy-3,5-dimethoxy-(1,1'-biphenyl)-2-O-beta-D-glucoside on the basis of spectroscopic analysis and chemical methods. Compounds 1-3 showed mild inhibitory activity against tyrosinase. PMID: 19731133 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2770467 Mon, 07 Sep 2009 03:38:02 +0100 2770467 http://www.medworm.com/index.php?rid=2770466&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19731134%26dopt%3DAbstract This study was aimed to investigate the effect of essential oil on human neutrophil (HN) functions. The neutrophils were isolated on percoll gradients, counted, and tested for viability using the trypan blue exclusion method. The chemotactic response was based on a multiple blind well assay system. The control movement and chemotactic response of neutrophils to 0.1 microM fMLP were reduced at a dose-dependent manner. The essential oil significantly inhibited neutrophil chemotaxis from 0.05 to 0.5 mg mL(-1). The inhibitory concentrations (IC(50)) showing 50% inhibition to induced neutrophil chemotaxis, and control movement were 0.08 and 0.07 mg mL(-1), respectively. The human neutrophil elastase secretion was inhibited by essential oil at a concentration dependent manner from 0.5 to 2.5 mg ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2770466 Mon, 07 Sep 2009 03:38:02 +0100 2770466 http://www.medworm.com/index.php?rid=2770465&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19731135%26dopt%3DAbstract Authors: Nedialkov PT, Zheleva-Dimitrova D, Girreser U, Kitanov GM Elegaphenonoside, a new benzophenone O-rhamnoside, together with two known benzophenone O-glycosides, namely hypericophenonoside and neoannulatophenonoside, were isolated from the aerial parts of Hypericum elegans Stephan ex Willd. The structure of the new compound was established as 3',5',6-trihydroxy-4-methoxybenzophenone-2-O-alpha-L-rhamnopyranoside by means of chemical and physical evidence. In addition, the presence of kaempferol, quercetin, isoquercitrin, norathyriol, I-3,II-8-biapigenin, quercitrin, hyperoside and rutin were established in this plant. PMID: 19731135 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2770465 Mon, 07 Sep 2009 03:38:02 +0100 2770465 http://www.medworm.com/index.php?rid=2770464&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19731136%26dopt%3DAbstract Authors: Niu ZR, Wang RF, Shang MY, Cai SQ A new iridoid glycoside, named 6'-O-cinnamoylharpagide (1), has been isolated from the roots of Scrophularia ningpoensis (Scrophulariaceae) together with nine known compounds, harpagide (2), harpagoside (3), 8-O-feruloylharpagide (4), 8-O-(p-coumaroyl)harpagide (5), 6-O-methylcatalpol (6), aucubin (7), buergerinin B (8), teuhircoside (9) and 6-O-cinnamoyl-D-glucopyranose (10). Compound 10 was obtained as an inseparable mixture of 6-O-cinnamoyl-alpha-D-glucopyranose and 6-O-cinnamoyl-beta-D-glucopyranose at a ratio of 1 : 1, which is presumably formed by cleavage of compound 1. Their structures were elucidated on the basis of chemical and spectral analysis. PMID: 19731136 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2770464 Mon, 07 Sep 2009 03:38:02 +0100 2770464 http://www.medworm.com/index.php?rid=2770463&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19731137%26dopt%3DAbstract Authors: Cirak C, Ivanauskas L, Janulis V, Radusiene J The present study was conducted out to determine hyperforin, hypericin, pseudohypericin, chlorogenic acid, rutin, hyperoside, quercitrin, quercetin, kaempferol, apigenin-7-O-glucoside and amentoflavone contents of Hypericum adenotrichum, an endemic plant species to Turkey. The aerial parts representing a total of 30 individuals were collected at full flowering, dried at room temperature and assayed for secondary metabolite concentrations by HPLC. All of the chemicals were detected at various levels except for hyperforin. This is the first report on polar chemistry of this endemic species. PMID: 19731137 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2770463 Mon, 07 Sep 2009 03:38:02 +0100 2770463 http://www.medworm.com/index.php?rid=2770462&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19731138%26dopt%3DAbstract Authors: Dai SJ, Shen L, Ren Y Two new eudesmane-type sesquiterpenoids, lyratol A-B (1 and 2), were isolated from the whole plant of Olanum lyratum Thunb and their structures were elucidated by extensive spectroscopic analyses. In addition, two new compounds were found to show significant cytotoxicity against selected cancer cells in vitro, including P-388 and HT-29. PMID: 19731138 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2770462 Mon, 07 Sep 2009 03:38:02 +0100 2770462 http://www.medworm.com/index.php?rid=2770461&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19731139%26dopt%3DAbstract Authors: Sharma RL, Prabhakar A, Dhar KL, Sachar A Five compounds have been isolated from the leaves of Vitex negundo Linn (Verbenacea) and their structures established by spectral analysis. Compound 1 has been identified and characterised as a new iridoid with a novel structure which has never before been reported in literature from Vitex or any other source. Its structure has been established as 1,4a,5,7a-tetrahydro-1-beta-D-glucosyl-7-(3',4'-dihydroxybenzoyloxymethyl)-5-ketocyclopenta[c]pyran-4-carboxylic acid. Other compounds, 2, 3, 4 and 5, have been identified as luteolin-7-O-beta-D glucoside, nishindaside, negundoside, and agnuside, respectively. Compound 2, a flavone-O-glycoside, is being reported from this plant for the first time, and compounds 3, 4 and 5 are structurally kno... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2770461 Mon, 07 Sep 2009 03:38:02 +0100 2770461 http://www.medworm.com/index.php?rid=2770460&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19731140%26dopt%3DAbstract Authors: Ramamoorthy S, Mudgal G, Rajesh D, Nawaz Khan F, Vijayakumar V, Rajasekaran C Oldenlandia umbellata L., commonly known as 'chay root', belongs to the family Rubiaceae and is one of the unexplored dye-yielding plants. The roots from this plant are the sources of red dye. Extraction protocol and dye characterisation have not been completely studied so far in this plant. Hence, in this article we have used UV spectrophotometry, thin layer chromatography, GC-MS, high-performance liquid chromatography and NMR to identify the five major colouring compounds, including 1,2,3-trimethoxyanthraquinone, 1,3-dimethoxy-2-hydroxyanthraquinone, 1,2-dimethoxyanthraquinone, 1-methoxy-2-hydroxyanthraquinone and 1,2-dihydroxyanthraquinone. It showed application feasibility as a new pH indicator. ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2770460 Mon, 07 Sep 2009 03:38:02 +0100 2770460 http://www.medworm.com/index.php?rid=2770459&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19731141%26dopt%3DAbstract Authors: Ramadan MA, Ahmad AS, Nafady AM, Mansour AI A new compound, 3-O-alpha-L-arabinopyranosyl-4-hydroxybenzoic acid (13), in addition to 16 newly reported compounds: alpha-amyrin acetate (1), beta-amyrone (2), 3beta-acetoxy-20-taraxasten-22-one (3), alpha-amyrin (4), ceryl alcohol (5), stigmasterol (6), beta-sitosterol (7), 2alpha,3alpha-dihydroxy-lup-20(29)-en-28-oate (8), ursolic acid (9), beta-sitosterol-3-O-glucosoide (10), protocatechuic acid (11), betulinic acid (12), quercetin (14), quercetin-3-O-beta-D-glucoside (15), kampferol-3-O-beta-neohesperidoside (16) and rutin (17) were isolated from the stem bark and leaves of Ficus pandurata (Hance) cultivated in Egypt. Identification of these compounds has been established by physical, chemical and spectral data (UV, IR, MS, (1)H... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2770459 Mon, 07 Sep 2009 03:38:02 +0100 2770459 http://www.medworm.com/index.php?rid=2770458&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19731142%26dopt%3DAbstract Authors: Herath W, Rakel Mikell J, Ahmad Khan I Microbial transformation of 7,8-dimethoxyflavone (1) by Mucor ramannianus produced five metabolites: 7,8-dimethoxy-4'-hydroxyflavone (2), 3',4'-dihydroxy-7,8-dimethoxyflavone (3), 7,3'-dihydroxy-8-methoxyflavone (4), 7,4'-dihydroxy-8-methoxyflavone (5) and 8-methoxy-7,3',4'-trihydroxyflavone (6). It was, however, completely converted to a single metabolite, 7-hydroxy-8-methoxyflavone (7) by Aspergillus flavus. 5-Methoxyflavone (8), when fermented with Beauveria bassiana, gave a single product, 5-methoxyflavanone (9). Conversion of 8 with Aspergillus alliaceus yielded the metabolite 4'-hydroxy-5-methoxyflavone (10). The structures of the compounds 2-7, 9 and 10 were established by spectroscopic methods. PMID: 19731142 [PubMed - in proc... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2770458 Mon, 07 Sep 2009 03:38:02 +0100 2770458 http://www.medworm.com/index.php?rid=2770457&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19731143%26dopt%3DAbstract Authors: Raghu Chandrashekhar H, Venkatesh P, Ponnusankar S, Vijayan P Methanolic extracts of leaf, root, flower and aerial parts of Hypericum hookerianum were assessed for in vitro antioxidant activity using eight different models. Total antioxidant capacity, phenol and flavanol content of the extracts were determined to correlate between their antioxidant activity and constituents present therein. Results of in vitro antioxidant study suggest that extracts from leaf and flower have strong antioxidant potential. Leaf extract (100 & 200 mg kg(-1) b.w. p.o.) that showed maximum activity was selected for in vivo antioxidant studies using a CCl(4)-intoxicated rat model. The effects of extracts on lipid peroxidation (LPO), superoxide dismutase (SOD) and catalase (CAT) in serum and live... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2770457 Mon, 07 Sep 2009 03:38:02 +0100 2770457 http://www.medworm.com/index.php?rid=2770456&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19731144%26dopt%3DAbstract Authors: Ragasa CY, Puno MR, Sengson JM, Shen CC, Rideout JA, Raga DD The ethyl acetate extract of the air-dried leaves of Diospyros blancoi afforded isoarborinol methyl ether (1), a mixture of alpha-amyrin palmitate, alpha-amyrin palmitoleate, beta-amyrin palmitate and beta-amyrin palmitoleate (2) in a 13 : 4 : 3 : 1 ratio, and squalene. The structures of 1, 2 and squalene were elucidated by extensive 1D and 2D NMR spectroscopy. Compounds 1 and 2 exhibited antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Staphylococcus aureus and Trichophyton mentagrophytes, and were found inactive against Bacillus subtilis and Aspergillus niger. Sample 2 exhibited significant analgaesic and anti-inflammatory activities. PMID: 19731144 [PubMed - in process... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2770456 Mon, 07 Sep 2009 03:38:02 +0100 2770456 http://www.medworm.com/index.php?rid=2770455&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19731145%26dopt%3DAbstract Authors: Hu XJ, Jin HZ, Zhang WD, Zhang W, Yan SK, Liu RH, Shen YH, Xu WZ Two new coumarins, 8-[3-(2,4-benzenediol)-propionic acid methyl ester]-coumarin-7-beta-D-glucoside (1) and 7-hydroxyl-odesmethoxyrutarensin (2), were isolated from the stems and barks of Edgeworthia chrysantha. Their structures were elucidated on the basis of spectroscopic data interpretation. PMID: 19731145 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2770455 Mon, 07 Sep 2009 03:38:02 +0100 2770455 http://www.medworm.com/index.php?rid=2682311&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662571%26dopt%3DAbstract Authors: Phuwapraisirisan P, Rangsan J, Siripong P, Tip-Pyang S Chemical investigation of the onion pathogenic fungus Alternaria porri resulted in the isolation of two new phthalides named zinnimide (2) and deprenylzinnimide (8), along with a new bianthraquinone, alterporriol F (10). The structures of the new metabolites were characterised by spectroscopic analysis and chemical degradation. Of the new compounds isolated, alterporriol F was highly cytotoxic towards HeLa and KB cells, with IC(50) values of 6.5 and 7.0 microg mL(-1). PMID: 19662571 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682311 Sat, 08 Aug 2009 17:00:03 +0100 2682311 http://www.medworm.com/index.php?rid=2682310&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662572%26dopt%3DAbstract Authors: Wang JL, Li Y, Lei CL The effects of the monoterpenes of 3-carene, 1,8-cineole, beta-pinene, terpinene and terpinolene on the repellent, contact toxicity of Tribolium castaneum adults and sustaining fumigant toxicity of Sitophilus zeamaise adults were examined. Monoterpene of 1,8-cineole in 20 microL mL(-1) and beta-pinene in 20 microL mL(-1) exhibited the highest percentage repellency, whereas 3-carene in concentration of 4 microL mL(-1) exhibited the significantly lower percentage repellency. Topical application and fumigant assays were used across a range of concentrations to develop dosage-mortality regressions. Among the monoterpenes tested, the most contact toxic compound was beta-pinene (with LC(50) values ranging between 31.44 and 62.07 microg mg(-1)), whereas 3-carene... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682310 Sat, 08 Aug 2009 17:00:03 +0100 2682310 http://www.medworm.com/index.php?rid=2682309&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662573%26dopt%3DAbstract Authors: Tanaka H, Hattori H, Oh-Uchi T, Sato M, Sako M, Tateishi Y, Rizwani GH Three new isoflavanones, 5,7,3'-trihydroxy-4'-methoxy-6,5'-di(gamma, gamma-dimethylallyl)-isoflavanone (1), 5,3'-dihydroxy-4'-methoxy-5'-gamma,gamma-dimethylallyl-2'',2''-dimethylpyrano[5,6 : 6,7]isoflavanone (2) and 5,3'-dihydroxy-2'',2''-dimethylpyrano[5,6 : 6,7]-2''',2'''-dimethylpyrano[5,6 : 5,4]isoflavanone (3), along with two known isoflavonoids, cristacarpin and euchrenone b(10), were isolated from the stems of Erythrina costaricensis. Their structures were established on the basis of spectroscopic evidence. Compound 3 is a rare isoflavanone possessing two 2,2-dimethylpyran moieties. Among the new isoflavanones, compound 1 showed potent antibacterial activity against methicillin-resistant Staphylococ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682309 Sat, 08 Aug 2009 17:00:03 +0100 2682309 http://www.medworm.com/index.php?rid=2682308&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662574%26dopt%3DAbstract Authors: Ben Ameur Mehdi R, Shaaban KA, Rebai IK, Smaoui S, Bejar S, Mellouli L Extraction of 25 L fermentation broth of the newly isolated Streptomyces sp. strain TN58 and various separation and purification steps led to the isolation of five bioactive metabolites, namely brevianamide F (C1), reported from a streptomycete for the first time, N(beta)-acetyltryptamine (C2), thiazolidomycin (C3), and two rhamnopyranosides (C4 and C5). These two rhamnopyranosides were produced directly, without precursor addition. The chemical structure of these five active compounds was established on the basis of (1)H, (13)C/APT and 2D NMR spectra, ESI and EI-MS data, and by comparison with data from the literature. According to the biological studies, we show in this work that the compounds C1, C2, C4 ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682308 Sat, 08 Aug 2009 17:00:03 +0100 2682308 http://www.medworm.com/index.php?rid=2682307&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662575%26dopt%3DAbstract Authors: Traore-Coulibaly M, Ziegler HL, Olsen CE, Hassanata MK, Pierre GI, Nacoulma OG, Guiguemde TR, Christensen SB A bioactivity guided fractionation of roots of Canthium multiflorum led to the isolation of the new ursenoic acid derivative 19alpha-hydroxy-3-oxo-ursa-1,12-dien-28-oic acid (1), which showed antiplasmodial effect without inducing change of the shape of membranes of erythrocytes. PMID: 19662575 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682307 Sat, 08 Aug 2009 17:00:03 +0100 2682307 http://www.medworm.com/index.php?rid=2682306&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662576%26dopt%3DAbstract Authors: Bae JS, Park JW, Park SH, Park JB, Rho YH, Ryu YB, Lee KS, Park KH, Bae YS A chloroform extract of the edible mushroom Pleurotus eryngii showed an inhibitory effect on mammalian DNA topoisomerase I. The topoisomerase I inhibitory compound was purified and identified as ubiquinone-9. Ubiquinone-9 was shown to inhibit the activity of topoisomerase I with IC(50) of about 50 microM. Concentration of 110 microM ubiquinone-9 caused 50% growth inhibition of human leukaemia U937 cells, but not that of normal fibroblast NIH3T3 and 3Y1 cells. Ubiquinone-9-induced cell death was characterised with the cleavage of poly (ADP-ribose) polymerase and pro-caspase 3. Furthermore, ubiquinone-9 induced the fragmentation of DNA into an apoptotic DNA ladder, indicating that the inhibitor triggered ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682306 Sat, 08 Aug 2009 17:00:03 +0100 2682306 http://www.medworm.com/index.php?rid=2682305&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662577%26dopt%3DAbstract Authors: Javaid A, Amin M Antifungal activity of methanol and n-hexane leaf, stem, root and inflorescence extracts (1, 2, 3 and 4% w/v) of three Chenopodium species (family Chenopodiaceae) namely Chenopodium album L., Chenopodium murale L. and Chenopodium ambrosioides L. was investigated against Macrophomina phaseolina (Tassi) G. Goid., a soil-borne fungal plant pathogen that has a broad host range and wide geographical distribution. All the extracts of the three Chenopodium species significantly suppressed the test fungal growth. However, there was marked variation among the various extract treatments. Methanol inflorescence extract of C. album exhibited highest antifungal activity resulting in up to 96% reduction in fungal biomass production. By contrast, methanol leaf extract of the... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682305 Sat, 08 Aug 2009 17:00:03 +0100 2682305 http://www.medworm.com/index.php?rid=2682304&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662578%26dopt%3DAbstract Authors: Khan NA, Srivastava A A novel oleanen type triterpenoid glycoside has been isolated from butanolic seed extracts of Cassia angustifolia. Its structure was elucidated as 3-O-{beta-D-glucuronopyranosyl-(1 --> 4)-[beta-D-galactopyranosyl-(1 --> 2)]-beta-D-xylopyranosyl-(1 --> 3)-beta-D-glucopyranosyl}-2, 16alpha-dihydroxy-4, 20-hydroxy methyl olean-12-ene-28-oic acid on the basis of spectral evidence (i.e. FTIR, (1)H NMR, (13)C NMR and FAB-MS data). The isolated saponin was tested for its antifungal activity, where the maximum inhibition was found in Colletotrichium dematium. PMID: 19662578 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682304 Sat, 08 Aug 2009 17:00:03 +0100 2682304 http://www.medworm.com/index.php?rid=2682303&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662579%26dopt%3DAbstract Authors: Maurya R, Gupta P, Chand K, Kumar M, Dixit P, Singh N, Dube A Two new compounds 4-methyl-heptadec-6-enoic acid ethyl ester (2) and 3-hydroxy-2,9,11-trimethoxy-5,6-dihydro isoquino[3,2-a]isoquinolinylium (7) were isolated from an ethanolic extract of the stems of Tinospora sinensis, along with six known compounds (1, 3-6 and 8). The structures of new compounds were established on the basis of detailed spectroscopic studies. Compound 7 exhibited the highest in vitro antileishmanial activity against Leishmania donovani promastigotes and intracellular amastigotes, whereas compounds 2, 4, 5 and 6 demonstrated moderate activity. Other compounds were found to be inactive. PMID: 19662579 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682303 Sat, 08 Aug 2009 17:00:03 +0100 2682303 http://www.medworm.com/index.php?rid=2682302&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662580%26dopt%3DAbstract Authors: Nkwengoua ET, Ngantchou I, Nyasse B, Denier C, Blonski C, Schneider B In an attempt to establish the components responsible for the use of Enantia chlorantha against cutaneous leishmaniasis in local traditional medicine, a well-known palmatine has been isolated in substantial amounts from a methanolic bark extract of this plant species. Palmatine therein obtained exhibited a significant inhibitory activity on growth of both Trypanosoma cruzi (IC(50) 0.068 microM) and Leishmania infantum (IC(50) 0.79 microM). PMID: 19662580 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682302 Sat, 08 Aug 2009 17:00:03 +0100 2682302 http://www.medworm.com/index.php?rid=2682301&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662581%26dopt%3DAbstract Authors: Sforcin JM, Amaral JT, Fernandes A, Sousa JP, Bastos JK Cymbopogon citratus has been widely recognised for its ethnobotanical and medicinal usefulness. Its insecticidal, antimicrobial and therapeutic properties have been reported, but little is known about its effect on the immune system. This work aimed to investigate the in vivo effect of a water extract of lemongrass on pro-inflammatory cytokine (IL-1beta and IL-6) production by macrophages of BALB/c mice. The action of lemongrass essential oil on cytokine production by macrophages was also analysed in vitro. The chemical composition of the extract and the oil was also investigated. Treatment of mice with water extract of lemongrass inhibited macrophages to produce IL-1beta but induced IL-6 production by these cells. Lemong... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682301 Sat, 08 Aug 2009 17:00:03 +0100 2682301 http://www.medworm.com/index.php?rid=2682300&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662582%26dopt%3DAbstract Authors: PMID: 19662582 [PubMed - in process] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682300 Sat, 08 Aug 2009 17:00:03 +0100 2682300 http://www.medworm.com/index.php?rid=2682315&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662567%26dopt%3DAbstract Authors: Tanaka T, Ogita A, Usuki Y, Fujita KI Nucleoside analogs have been evaluated as useful tools for the investigation of the mechanism of cell differentiation. We thus examined the effects of nucleoside 5'-alkylphosphates (1-10) on the morphogenetic development of starfish embryos. These nucleotide derivatives were all permissive for their development up to the blastula stage, but the derivatives with lauryl side chain selectively inhibited one of the following stages into bipinnaria larvae. Among them, uridine 5'-laurylphosphate (2) inhibited gastrulation of the blastula, as is the case with the antibiotic tunicamycin, suggesting its inhibitory activity on sulfated and non-sulfated glycoprotein syntheses. Unexpectedly, adenosine 5'-laurylphosphate (8) was evaluated as a novel cl... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682315 Wed, 05 Aug 2009 23:00:00 +0100 2682315 http://www.medworm.com/index.php?rid=2682314&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662568%26dopt%3DAbstract Authors: Bose SK, Dewanjee S, Sahu R, Dey SP In the present investigation, the anti-inflammatory activity of isolated bergapten from hydroalcoholic extract of Heracleum nepalense root was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs). Bergapten exhibited significant inhibition of the production of pro-inflammatory cytokines, namely tumour necrotic factor-alpha (TNF-alpha) and interleukin-6 (IL-6) by PBMCs stimulated with lipopolysaccharide in a concentration-dependent manner. PMID: 19662568 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682314 Wed, 05 Aug 2009 23:00:00 +0100 2682314 http://www.medworm.com/index.php?rid=2682313&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662569%26dopt%3DAbstract Authors: Si CL, Li SM, Liu Z, Kim JK, Bae YS Study on the EtOAc soluble fraction from the bark of Populus ussuriensis Kom. resulted in the isolation of three phenolic glycosides, including populoside (1), 7-O-rho-coumaroylsalirepin (2) and 7-O-caffeoylsalirepin (3), among which 3 is a new compound. The structures of these compounds were elucidated on the basis of spectroscopic evidence. Phenolic glycosides 1-3 exhibited excellent antioxidant activity, evaluated in the ABTS(+) radical scavenging assay. PMID: 19662569 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682313 Wed, 05 Aug 2009 23:00:00 +0100 2682313 http://www.medworm.com/index.php?rid=2682312&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19662570%26dopt%3DAbstract Authors: Razavi SM, Nejad-Ebrahimi S Crambe orientalis L. (Brassicaceae), a perennial herb, is indigenous to Iran. The essential oils of flowering tops and leaves of the plant were evaluated by GC-MS. Our results showed that while 2-methyl-5-hexenitrile (19.5%) and benzyl cyanide (16.9%) were the major components of flowering tops oil, the oil of the leaves was dominated by octyl-acetate (54.3%) and butenyl-4-isothiocyanates (22.6%). The oils exhibited modest allelopatic effects on lettuce. The leaf oil showed high-cytotoxic effects against Mc-Coy cell lines, with an RC(50) value of 16 microg mL(-1). PMID: 19662570 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682312 Wed, 05 Aug 2009 23:00:00 +0100 2682312 http://www.medworm.com/index.php?rid=2682316&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19657970%26dopt%3DAbstract Authors: Dewanjee S, Mandal V, Sahu R, Dua TK, Manna A, Mandal SC In the present investigation, the anti-inflammatory activity of a polyphenolic enriched extract of Schima wallichii bark was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs) and in vivo by carrageenan-induced paw oedema assay (acute study) and cotton pallet granuloma assay (chronic study). The extract exhibited significant inhibition of the production of tumour necrotic factor-alpha and interleukin-6 by PBMCs stimulated with lipopolysaccharide (LPS) in a concentration-dependent manner. The extract at the selected doses of 150 and 300 mg kg(-1) body weight p.o. exhibited significant dose-dependent anti-inflammatory responses, with 44.32 and 38.65% inhibition of inflammation in carrageenan-induced ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2682316 Thu, 30 Jul 2009 23:00:00 +0100 2682316 http://www.medworm.com/index.php?rid=2611260&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19606380%26dopt%3DAbstract Authors: Ding L, Zhou Q, Wang L, Wang W, Zhang S, Liu B The cytotoxicity of six ent-kaurene diterpenoids isolated from the leaves of Isodon japonica (Burm.f.) Hara var. galaucocalyx (maxin) Hara was evaluated against three human tumour HepG2, GLC-82 and HL-60 cell lines through SRB assay, and their DNA damage potential (against HepG2 cell line) was assessed by comet assay. Among the six ent-kaurene diterpenoids, Rabdosin B was most cytotoxic, followed by Oridonin, Epinodosin, Rabdosinate, Lasiokaurin and Epinodosinol. All of the six ent-kaurene diterpenoids induced significant DNA damage (p < 0.05) to HepG2 cells in a time- and dose-dependent manner except Lasiokaurin and Eponodosinol at 6 micromol L(-1) for 24 h. The structure-activity relationships (SARs) were discussed and it was... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2611260 Tue, 14 Jul 2009 23:00:00 +0100 2611260 http://www.medworm.com/index.php?rid=2611259&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19606381%26dopt%3DAbstract Authors: Razavi SM, Nejad-Ebrahimi S The chemical composition of essential oil obtained by hydrodistillation from the dried fruits of Zosima absinthifolia was analysed by GC-MS. Twenty-four compounds were characterised in the oil. The major components of the oil were octyl acetate (87.48%), octyl octanoate (5.03%) and 1-octanol (2.37%). The oil showed modest to weak allelopatic effects and high antibacterial effects against Bacillus subtilis, Bacillus pumilus and further modest to strong effects on different bacteria and fungi. PMID: 19606381 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2611259 Mon, 13 Jul 2009 23:00:00 +0100 2611259 http://www.medworm.com/index.php?rid=2611258&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19606382%26dopt%3DAbstract Authors: Latha M, Pari L, Ramkumar KM, Rajaguru P, Suresh T, Dhanabal T, Sitasawad S, Bhonde R We evaluated the antihyperglycaemic effect of scoparic acid D (SAD), a diterpenoid isolated from the ethanol extract of Scoparia dulcis in streptozotocin (STZ)-induced diabetic male Wistar rats. SAD was administered orally at a dose of 10, 20 and 40 mg kg(-1) bodyweight for 15 days. At the end of the experimental period, the SAD-treated STZ diabetic rats showed decreased levels of glucose as compared with diabetic control rats. The improvement in blood glucose levels of SAD-treated rats was associated with a significant increase in plasma insulin levels. SAD at a dose of 20 mg kg(-1) bodyweight exhibited a significant effect when compared with other doses. Further, the effect of SAD was teste... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2611258 Mon, 13 Jul 2009 23:00:00 +0100 2611258 http://www.medworm.com/index.php?rid=2611257&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19606383%26dopt%3DAbstract Authors: Zhang Y, Li XM, Feng Y, Wang BG Two new phenethyl-alpha-pyrone derivatives including, isopyrophen (1) and aspergillusol (2), were characterised from the culture extract of Aspergillus niger EN-13, an endophytic fungus isolated from the inner tissue of the marine brown alga Colpomenia sinuosa. In addition, four known compounds, including a phenethyl-alpha-pyrone derivative (pyrophen, 3) and three cyclodipeptides (4-6), were also isolated and identified. The structures of these compounds were elucidated by spectroscopic methods. PMID: 19606383 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2611257 Mon, 13 Jul 2009 23:00:00 +0100 2611257 http://www.medworm.com/index.php?rid=2611256&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19606384%26dopt%3DAbstract Authors: Razavi SM, Nejad-Ebrahimi S The hydrodistillated essential oils from leaves and fruits of Ecballium elaterium were analysed by GC-MS. Octyl octanoate (30.0%), 3-(6,6- dimethyl-5-oxohept-2-enyl)-cyclohexanone (20.4%) and hexahydro farnesyl acetone (19.1%) were the main components among 21 constituents characterised in the leaf oil. Twenty-one compounds were also identified in the oil of the fruits, with E-anethol (31.6%) and 3-(6,6-dimethyl-5-oxohept-2-enyl)-cyclohexanone (8.8%) as the main constituents. Furthermore, allelopatic activity of the oils was evaluated using lettuce assay method. The leaf oil exhibited strong allelopathy effects against lettuce. PMID: 19606384 [PubMed - as supplied by publisher] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2611256 Mon, 13 Jul 2009 23:00:00 +0100 2611256 http://www.medworm.com/index.php?rid=2611255&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19606385%26dopt%3DAbstract Authors: Razavi SM, Zarrini G, Zahri S, Mohammadi S Prangos uloptera DC. (Apiaceae) is indigenous to Iran. It has been used from ancient times for treatment of leukoplakia, digestive disorders and healing scars. In this article, we focus on the various biological screening techniques currently being used to evaluate the biological effects of the plant root extracts. Our results show that dichloromethane (DCM) extract exhibited high-cytotoxic effects on hela cell line, and high antibacterial properties against Staphylococcus aureus and Bacillus subtilis. All of the plant root extracts, n-hexane, DCM and methanol extracts, exhibited modest antioxidant and high-phytotoxic properties. It is assumed that the high biological potential of P. uloptera is related to the presence of coumarins in... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2611255 Mon, 13 Jul 2009 23:00:00 +0100 2611255 http://www.medworm.com/index.php?rid=2611254&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19606386%26dopt%3DAbstract Authors: Razavi SM, Nazemiyeh H, Delazar A, Asnaashari S, Hajiboland R, Sarker SD, Omidi Y In the current investigation, the influence of the plant growth stages (prior to emergence of flower heads or vegetative, anthesis and fruiting) on the essential oil content and composition in the aerial parts of Prangos uloptera DC. was studied. Quantitative and qualitative differences were found among oil of aerial parts at three phenological stages. The principle compounds of the oil before emergence of flower heads were saferole (21.6%) and alpha-pinene (20%), while the oil at anthesis was composed of alpha-bisabolol (30.5%), saferole (19.11%) and (+)-spathulenol (12.9%). The oil at fruiting stage displayed gamma-terpinene (35.5%) and trans-anethole (23.5%) as major constituents. These findin... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2611254 Mon, 13 Jul 2009 23:00:00 +0100 2611254 http://www.medworm.com/index.php?rid=2602675&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19593704%26dopt%3DAbstract Authors: Huang GL Chitooligosaccharides (COSs) have demonstrated a diverse array of biological activities. Here we report a concise preparation method for tetra-N-acetyl-chitotetraose and penta-N-acetyl-chitopentaose. The FACE analysis showed that the partially N-acetylated COS mixture mainly contained glucosamine (GlcN) and some oligomers [(GlcN)(n), n = 2-7]. The N-acetyl-D-glucosamine (GlcNAc) and peracetylated COSs [(GlcNAc)(n), n = 2-7] were synthesised by treating the partially N-acetylated COS mixture with Ac(2)O-NaOAc. The peracetylated chitotetraose and chitopentaose were obtained by isolation of peracetylated COS mixture. NaOMe in dry MeOH was used for the deacetylation of peracetylated chitotetraose and chitopentaose, to give the tetra-N-acetyl-chitotetraose and penta-N-acet... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2602675 Thu, 09 Jul 2009 23:00:00 +0100 2602675 http://www.medworm.com/index.php?rid=2592119&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19588279%26dopt%3DAbstract Authors: Jabeen K, Javaid A Aqueous, ethanol and n-hexane extracts from leaves, fruit, root-bark and stem-bark of Syzygium cumini (L.) Skeels were tested for their antifungal activity against Ascochyta rabiei (Pass.) Lab., the cause of blight disease of the chickpea (Cicer arietinum L.). Different concentrations, namely 1, 2, ..., 5% of both aqueous and the two organic solvent extracts were used in this study. Aqueous extracts of all the four test plant parts, namely leaves, fruit, stem-bark and root-bark, showed significant antifungal activity resulting in 7-30%, 22-59%, 23-39% and 21-64% reduction in fungal growth, respectively. Similarly, n-hexane stem-bark extract, and ethanol root- and stem-bark extracts also significantly suppressed the growth of target fungal species, resulting ... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2592119 Sun, 05 Jul 2009 23:00:00 +0100 2592119 http://www.medworm.com/index.php?rid=2546808&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19384727%26dopt%3DAbstract Authors: Iqbal Choudhary M, Ali Siddiqui Z, Ahmed Nawaz S The microbial transformation of 18beta-glycyrrhetinic acid (1) by Cunninghamella elegans afforded a metabolite, 3beta,7beta-dihydroxy-11-oxo-olean-12-en-30-oic acid (2), while fermentation of 1 with Fusarium lini afforded a metabolite, 3,11-dioxo-olean-12-en-30-oic acid (3). Compound 3 exhibited a potent lipoxygenase (LOX) inhibitory activity. The structures of these metabolites were elucidated on the basis of spectroscopic techniques. PMID: 19384727 [PubMed - indexed for MEDLINE] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2546808 Sun, 28 Jun 2009 03:54:03 +0100 2546808 http://www.medworm.com/index.php?rid=2546806&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19384728%26dopt%3DAbstract This article reports the results of selected biological activities, including anticholinesterase, antioxidant, antibacterial, antifungal and antiviral properties, of the petroleum ether, chloroform and methanol extracts as well as the alkaloid fraction of Lycopodium complanatum L. ssp. chamaecyparissus (A. Br.) Doll (LCC, Lycopodiaceae) growing in Turkey. Anticholinesterase effect of the extracts was tested against both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at concentrations of 0.2 and 1 mg mL(-1) using microplate-reader assay based on Ellman method. Antioxidant activity of the LCC extracts was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging method at 0.2 mg mL(-1) using microplate-reader assay. Both DNA virus Herpes simplex (HSV) and RNA virus P... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2546806 Sun, 28 Jun 2009 03:54:03 +0100 2546806 http://www.medworm.com/index.php?rid=2546804&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19384729%26dopt%3DAbstract Authors: Zhu XF, Zhang HX, Lo R Three di-O-caffeoylquinic acid derivatives were isolated from the ethanol extracts of the heads of Cynara scolymus L. Their structures were elucidated based on spectra analyses. PMID: 19384729 [PubMed - indexed for MEDLINE] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2546804 Sun, 28 Jun 2009 03:54:03 +0100 2546804 http://www.medworm.com/index.php?rid=2546802&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19384730%26dopt%3DAbstract Authors: Dharmaratne HR, Napagoda MT, Tennakoon SB Extracts from three Calophyllum species endemic to Sri Lanka were tested for antifungal and antioxidant activities. Of them, only the root methanol extract of Calophyllum thwaitesii showed activity, and the active extract on activity guided fractionation yielded four antifungal active and three inactive xanthones. Antifungal active xanthones were identified as 1,6-dihydroxy-5-methoxyxanthone, 1-hydroxy-5,6-dimethoxyxanthone, 1-hydroxy-5-methoxyxanthone and 1-methoxy-5-hydroxyxanthone, using spectroscopic methods and comparison with literature data. Inactive compounds were identified as 1-hydroxy-7-methoxyxanthone, 1,5-dihydroxy-6-methoxyxanthone and 1,7-dihydroxy xanthone. This is the first report of above xanthones except the latter f... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2546802 Sun, 28 Jun 2009 03:54:03 +0100 2546802 http://www.medworm.com/index.php?rid=2546800&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19384731%26dopt%3DAbstract The volatile constituents analysis of Lallemantia iberica (M.B.) Fischer & Meyer from Iran. Nat Prod Res. 2009;23(6):546-8 Authors: Nori-Shargh D, Kiaei SM, Deyhimi F, Mozaffarian V, Yahyaei H The volatile constituents of the aerial parts of Lallemantia iberica growing wild in Iran have been examined by GC-FID and GC-MS. Altogether, 11 compounds were identified, constituting approximately 97.2% of the oil. The oil of L. iberica consisted mainly of germacrene-D (33.7%), delta-3-carene (19.0%), iso-caryophyllene (12.8%), sabinene (11.1%), alpha-terpinene acetate (6.5%) and limonene (4.4%). PMID: 19384731 [PubMed - indexed for MEDLINE] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2546800 Sun, 28 Jun 2009 03:54:03 +0100 2546800 http://www.medworm.com/index.php?rid=2546798&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19384732%26dopt%3DAbstract Authors: Djenontin ST, Wotto VD, Lozano P, Pioch D, Sohounhloue DK A sample of Blighia sapida seeds collected in Benin has been analysed and the results are compared to the scarcely available literature data. The chemical analysis of seed oil shows a saponification value of 145 and an iodine value of 66, consistent with the high mono-unsaturated fatty acids (FAs) content (63.8 wt%). The most interesting feature is the prominent concentration of eicosenoic acid (48.4 wt%). Arachidic acid being the main component within the saturated group, the C20 FAs fraction accounts for 68.4 wt%, thus making the peculiar composition of this oil. Among the unsaponifiable fraction (2.4 wt%), the major sterol is stigmasterol (54.6 wt%), surprisingly over passing beta-sitosterol. Tocols (338 ppm) contain... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2546798 Sun, 28 Jun 2009 03:54:03 +0100 2546798 http://www.medworm.com/index.php?rid=2546796&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19384733%26dopt%3DAbstract This study provides further insight into the potential use of mixtures of terpenoids as they occur in nature, as inducers of apoptosis in cancer cells. PMID: 19384733 [PubMed - indexed for MEDLINE] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2546796 Sun, 28 Jun 2009 03:54:03 +0100 2546796 http://www.medworm.com/index.php?rid=2546794&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19384734%26dopt%3DAbstract In conclusion, this study confirms that T. spicata essential oil could be considered as a natural antimicrobial source. PMID: 19384734 [PubMed - indexed for MEDLINE] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2546794 Sun, 28 Jun 2009 03:54:03 +0100 2546794 http://www.medworm.com/index.php?rid=2546791&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19384735%26dopt%3DAbstract Authors: Wang D, Li D, Zhu W, Peng P A new C-methylated homoisoflavanone together with four known rare methyl-homoisoflavanones and one known 9,19-cyclolart triterpenoid were isolated and characterised from the rhizomes of Polygonatum odoratum. The structure of the new compound was determined as 3-(4'-methoxy-benzyl)-5,7-dihydroxy-6-methyl-8-methoxy-chroman-4-one (1). The four known methyl-homoisoflavanones were determined as 3-(4'-methoxy-benzyl)-5,7-dihydroxy-6,8-dimethyl-chroman-4-one (2), 3-(4'-hydroxy-benzyl)-5,7-dihydroxy-6,8-dimethyl-chroman-4-one (3), 3-(4'-hydroxy-benzyl)-5,7-dihydroxy-6-methyl-8-methoxy-chroman-4-one (4) and 3-(4'-hydroxy-benzyl)-5,7-dihydroxy-6-methyl-chroman-4-one (5). The one 9,19-cyclolart triterpenoid was determined as 9,19-cyclolart-25-en-3beta,24 (R)-d... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2546791 Sun, 28 Jun 2009 03:54:03 +0100 2546791 http://www.medworm.com/index.php?rid=2546789&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19401910%26dopt%3DAbstract Authors: Syah YM, Hakim EH, Ghisalberti EL, Jayuska A, Mujahidin D, Achmad SA A new oligostilbenoid, diptoindonesin C, has been isolated from the tree bark of Shorea pinanga Scheff., along with the two known oligostilbenoids gnetin H and hopeaphenol, and a known coumarin scopoletin. The new oligostilbenoid was moderately active against brine shrimps Artemia salina. PMID: 19401910 [PubMed - indexed for MEDLINE] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2546789 Sun, 28 Jun 2009 03:54:03 +0100 2546789 http://www.medworm.com/index.php?rid=2546787&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19401911%26dopt%3DAbstract Authors: Begum AS, Verma S, Sahai M, Schneider K, Süssmuth R In addition to the isolation and complete characterisation of a new lignan, hyoscyamal, three other compounds, balanophonin, pongamoside C and pongamoside D have been isolated from the seeds of Hyoscyamus niger. The structures of the compounds were settled on the basis of spectroscopic analysis. This is the first report on the isolation of these compounds from a solanaceous plant. PMID: 19401911 [PubMed - indexed for MEDLINE] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2546787 Sun, 28 Jun 2009 03:54:03 +0100 2546787 http://www.medworm.com/index.php?rid=2546785&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19401912%26dopt%3DAbstract Authors: Amiri H Ziziphora clinopodioides belongs to the Lamiaceae family, that are widespread all over Iran. The leaves, flowers and stems of the plant are frequently used as wild vegetables or additives in food to offer aroma and flavour. The chemical composition of the essential oils obtained from the aerial parts of Z. clinopodioides Lam. in different growth stages were analysed by GC and GC-MS, and 29 components were identified. Pulegone (30.1%), thymol (21.3%), p-mentha-3-en-8-ol (12.9%) and piperitenone (9.3%) were the main components in the pre-flowering stage. In the flowering stage, pulegone (44.6%), p-mentha-3-en-8-ol (10.5%), 1,8-cineoil (10.4%), piperitenone (8.7%) and thymol (6.7%) were identified as the main constituents and in the post-flowering stage, pulegone (41.3%),... Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2546785 Sun, 28 Jun 2009 03:54:03 +0100 2546785 http://www.medworm.com/index.php?rid=2546783&cid=s_36744_60_f&fid=36744&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19401913%26dopt%3DAbstract Authors: Volk RB, Girreser U, Al-Refai M, Laatsch H A new brominated indole alkaloid, designated as bromoanaindolone, was isolated from culture media of the cyanobacterium Anabaena constricta and was identified as 6-bromo-3-hydroxy-3-methyl-indol-2-one with a slight excess of the (3R) enantiomer. The molecular structure was elucidated on the basis of IR, MS and NMR data. This extracellular metabolite of A. constricta possessed antimicrobial (anticyanobacterial and antibacterial) activity in different test systems, such as suspension and porous matrix tests. PMID: 19401913 [PubMed - indexed for MEDLINE] (Source: Natural Product Research) Natural Product Research journals http://www.medworm.com/rss/comments.php?id=2546783 Sun, 28 Jun 2009 03:54:03 +0100 2546783