Nature Cell Biology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nature Cell Biology' source. Tue, 07 Feb 2012 08:49:00 +0100 COPII and the regulation of protein sorting in mammals http://www.medworm.com/index.php?rid=5657988&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F0iBLT2cn_S4%2Fncb2434 Nature Cell Biology 14, 221 (2012). doi:10.1038/ncb2434 Author: Giulia Zanetti, Kanika Bajaj Pahuja, Sean Studer, Soomin Shim & Randy Schekman (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657988 Thu, 02 Feb 2012 05:00:00 +0100 5657988 Increasing organismal healthspan by enhancing mitochondrial protein quality control http://www.medworm.com/index.php?rid=5657987&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FIByyRfyJQqE%2Fncb2433 Nature Cell Biology 14, 220 (2012). doi:10.1038/ncb2433 Author: Karin Luce & Heinz D. Osiewacz (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657987 Thu, 02 Feb 2012 05:00:00 +0100 5657987 A mitochondria–lysosome transport pathway http://www.medworm.com/index.php?rid=5657976&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FFCPtPDrdSbA%2Fncb2439 A mitochondria–lysosome transport pathway Nature Cell Biology 14, 130 (2012). doi:10.1038/ncb2439 Author: Emily J. Chenette (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657976 Thu, 02 Feb 2012 05:00:00 +0100 5657976 Actin gets the oxidation treatment from Mical http://www.medworm.com/index.php?rid=5657975&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FMtIpRFBH6mg%2Fncb2438 Nature Cell Biology 14, 130 (2012). doi:10.1038/ncb2438 Author: Alexia-Ileana Zaromytidou (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657975 Thu, 02 Feb 2012 05:00:00 +0100 5657975 Aggregation is key for chimeric monkeys http://www.medworm.com/index.php?rid=5657974&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FK1e3LA9wm9I%2Fncb2437 Nature Cell Biology 14, 130 (2012). doi:10.1038/ncb2437 Author: Nathalie Le Bot (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657974 Thu, 02 Feb 2012 05:00:00 +0100 5657974 Controlling enteric nerve cell migration http://www.medworm.com/index.php?rid=5657973&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FeVkYYzcm-U8%2Fncb2436 Nature Cell Biology 14, 130 (2012). doi:10.1038/ncb2436 Author: Christina Karlsson Rosenthal (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657973 Thu, 02 Feb 2012 05:00:00 +0100 5657973 Ras hitchhikes on PDE6δ http://www.medworm.com/index.php?rid=5657972&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FBrOjjJF6IRg%2Fncb2429 Ras hitchhikes on PDE6δ Nature Cell Biology 14, 128 (2012). doi:10.1038/ncb2429 Author: Mark R. Philips Ras GTPases are tethered to cellular membranes by a farnesyl lipid that modifies a carboxy-terminal cysteine. One of the ways Ras traffics between membranes is via fluid-phase diffusion, suggesting that a cytosolic chaperone might be needed to shield the farnesyl lipid during transport. PDE6δ is now revealed to be a farnesyl-binding chaperone that facilitates the trafficking and signalling of Ras. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657972 Thu, 02 Feb 2012 05:00:00 +0100 5657972 Efficient generation of adipocytes in a dish http://www.medworm.com/index.php?rid=5657971&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fcy_CcfDvGxU%2Fncb2430 Authors: Andrew G. Elefanty & Edouard G. Stanley A protocol for efficient differentiation of human pluripotent stem cells into white and brown adipocytes now enables their detailed examination at a cellular and molecular level, facilitating the study of adipocyte dysfunction in a range of metabolic diseases including diabetes, heart disease and obesity. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657971 Thu, 02 Feb 2012 05:00:00 +0100 5657971 Stromal miR-320 keeps an oncogenic secretome in check http://www.medworm.com/index.php?rid=5657970&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FwqCCe_kWzjs%2Fncb2431 Authors: Yeesim Khew-Goodall & Gregory J. Goodall Cancer-associated fibroblasts contribute to malignancy by expressing secreted pro-tumorigenic molecules. The microRNA miR-320 is now shown to be a crucial component of a PTEN-controlled tumour-suppressive axis in stromal fibroblasts. Loss of PTEN and miR-320 induces an oncogenic secretome that reprogrammes the tumour microenvironment to promote invasion and angiogenesis. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657970 Thu, 02 Feb 2012 05:00:00 +0100 5657970 Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system http://www.medworm.com/index.php?rid=5657969&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FOckN5rTThmg%2Fncb2407 Authors: Hemmo Meyer, Monika Bug & Sebastian Bremer (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657969 Thu, 02 Feb 2012 05:00:00 +0100 5657969 Finding MyoD with a little help from my friends http://www.medworm.com/index.php?rid=5657968&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FvxGm7CSG2Ck%2Fncb2421 Nature Cell Biology 14, 116 (2012). doi:10.1038/ncb2421 Author: Andrew Lassar (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657968 Thu, 02 Feb 2012 05:00:00 +0100 5657968 On target: A public repository for large-scale RNAi experiments http://www.medworm.com/index.php?rid=5657967&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FIv-O_KVoMSQ%2Fncb2435 Authors: Caroline E. Shamu, Stefan Wiemann & Michael Boutros Many RNA interference (RNAi) screens are now performed to functionally annotate the mammalian genome. Implementing a public repository based on common data standards is essential to realize the full value of largescale RNAi data sets. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657967 Thu, 02 Feb 2012 05:00:00 +0100 5657967 The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity http://www.medworm.com/index.php?rid=5657985&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FCiy8yeZPY3c%2Fncb2424 Authors: Daniel E. Foxler, Katherine S. Bridge, Victoria James, Thomas M. Webb, Maureen Mee, Sybil C. K. Wong, Yunfeng Feng, Dumitru Constantin-Teodosiu, Thorgunnur Eyfjord Petursdottir, Johannes Bjornsson, Sigurdur Ingvarsson, Peter J. Ratcliffe, Gregory D. Longmore & Tyson V. Sharp There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O2 tension. In high O2 tension (normoxia) the PHDs hydroxylate two conserved proline residues on HIF-1α, which leads to binding of the von Hippel–Lindau (VHL) tumour suppressor, the recognition component of a ubiquitin–ligase complex, initiating HIF-1α ubiquitylation and degradation. However, it is not kn... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657985 Sun, 29 Jan 2012 05:00:00 +0100 5657985 APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1 http://www.medworm.com/index.php?rid=5657981&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F51k-7IVP5VQ%2Fncb2425 Authors: Nevena V. Dimova, Nathaniel A. Hathaway, Byung-Hoon Lee, Donald S. Kirkpatrick, Marie Lea Berkowitz, Steven P. Gygi, Daniel Finley & Randall W. King (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657981 Sun, 29 Jan 2012 05:00:00 +0100 5657981 Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells http://www.medworm.com/index.php?rid=5657982&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FyxHu-kv0F3Y%2Fncb2422 Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells Nature Cell Biology 14, 177 (2012). doi:10.1038/ncb2422 Authors: Lei Liu, Du Feng, Guo Chen, Ming Chen, Qiaoxia Zheng, Pingping Song, Qi Ma, Chongzhuo Zhu, Rui Wang, Wanjun Qi, Lei Huang, Peng Xue, Baowei Li, Xiaohui Wang, Haijing Jin, Jun Wang, Fuquan Yang, Pingsheng Liu, Yushan Zhu, Senfang Sui & Quan Chen Accumulating evidence has shown that dysfunctional mitochondria can be selectively removed by mitophagy. Dysregulation of mitophagy is implicated in the development of neurodegenerative disease and metabolic disorders. How individual mitochondria are recognized for removal and how this process is regulated remain poorly understood. Here we report that FUNDC1, an integral ... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657982 Sun, 22 Jan 2012 05:00:00 +0100 5657982 Endocytosis by Numb breaks Notch symmetry at cytokinesis http://www.medworm.com/index.php?rid=5657977&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FLA6AJNKPT98%2Fncb2419 Endocytosis by Numb breaks Notch symmetry at cytokinesis Nature Cell Biology 14, 131 (2012). doi:10.1038/ncb2419 Authors: Lydie Couturier, Nicolas Vodovar & François Schweisguth (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657977 Sun, 22 Jan 2012 05:00:00 +0100 5657977 Programming human pluripotent stem cells into white and brown adipocytes http://www.medworm.com/index.php?rid=5657986&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FQ9g75fgJyVU%2Fncb2411 Authors: Tim Ahfeldt, Robert T. Schinzel, Youn-Kyoung Lee, David Hendrickson, Adam Kaplan, David H. Lum, Raymond Camahort, Fang Xia, Jennifer Shay, Eugene P. Rhee, Clary B. Clish, Rahul C. Deo, Tony Shen, Frank H. Lau, Alicia Cowley, Greg Mowrer, Heba Al-Siddiqi, Matthias Nahrendorf, Kiran Musunuru, Robert E. Gerszten, John L. Rinn & Chad A. Cowan (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657986 Sun, 15 Jan 2012 05:00:00 +0100 5657986 Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B http://www.medworm.com/index.php?rid=5657984&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FkC6wu2n7Ky4%2Fncb2408 Authors: Connie W. Woo, Lydia Kutzler, Scot R. Kimball & Ira Tabas Activation of Toll-like receptors (TLRs) induces the endoplasmic reticulum (ER) unfolded protein response (UPR) to accommodate essential protein translation. However, despite increased levels of phosphorylated eIF2α (p-eIF2α), a TLR–TRIF-dependent pathway assures that the cells avoid CHOP induction, apoptosis and translational suppression of critical proteins. As p-eIF2α decreases the functional interaction of eIF2 with eIF2B, a guanine nucleotide exchange factor (GEF), we explored the hypothesis that TLR–TRIF signalling activates eIF2B GEF activity to counteract the effects of p-eIF2α. We now show that TLR–TRIF signalling activates eIF2B GEF through PP2A-mediated serine dephosphory... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657984 Sun, 08 Jan 2012 05:00:00 +0100 5657984 Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation http://www.medworm.com/index.php?rid=5657978&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fe19DPoU5N3E%2Fncb2406 Authors: J. L. Stubbs, E. K. Vladar, J. D. Axelrod & C. Kintner (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657978 Sun, 08 Jan 2012 05:00:00 +0100 5657978 CRAF breaks up with MEK to regulate mitosis in cancer http://www.medworm.com/index.php?rid=5535452&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fi9UtSwpr4U4%2Fncb2418 Nature Cell Biology 14, 50 (2012). doi:10.1038/ncb2418 Author: Alexia-Ileana Zaromytidou (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535452 Thu, 22 Dec 2011 05:00:00 +0100 5535452 Autophagy proteins regulate bone resorption http://www.medworm.com/index.php?rid=5535451&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F_2BtEcm7HpI%2Fncb2417 Nature Cell Biology 14, 50 (2012). doi:10.1038/ncb2417 Author: Emily J. Chenette (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535451 Thu, 22 Dec 2011 05:00:00 +0100 5535451 A pituitary gland in a dish http://www.medworm.com/index.php?rid=5535450&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FPQiGKL_KFHI%2Fncb2416 Nature Cell Biology 14, 50 (2012). doi:10.1038/ncb2416 Author: Nathalie Le Bot (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535450 Thu, 22 Dec 2011 05:00:00 +0100 5535450 pH-dependent invadopodia control http://www.medworm.com/index.php?rid=5535449&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FgRqmIrjTLAM%2Fncb2414 Nature Cell Biology 14, 50 (2012). doi:10.1038/ncb2414 Author: Christina Karlsson Rosenthal (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535449 Thu, 22 Dec 2011 05:00:00 +0100 5535449 c-Cbl targets active Src for autophagy http://www.medworm.com/index.php?rid=5535448&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fntef906pKSw%2Fncb2413 Nature Cell Biology 14, 48 (2012). doi:10.1038/ncb2413 Author: Francesco Cecconi Autophagy can promote both cancer cell survival and death, and the mechanisms by which it mediates these disparate processes are under intense investigation. Autophagosomes are now shown to entrap and promote degradation of the active tyrosine kinase Src, enabling tumour cell survival. The E3 ubiquitin ligase c-Cbl acts as an autophagosome cargo receptor for Src. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535448 Thu, 22 Dec 2011 05:00:00 +0100 5535448 Navigating the ERAD interaction network http://www.medworm.com/index.php?rid=5535447&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FU7PDbGzVHnk%2Fncb2412 Nature Cell Biology 14, 46 (2012). doi:10.1038/ncb2412 Author: Thibault Mayor The endoplasmic reticulum (ER)-associated protein degradation (ERAD) pathway, which orchestrates the degradation of ER proteins by the proteasome, involves a plethora of proteins with diverse functions. Using a combination of proteomic and genetic approaches, a recent study provides fresh insights into the organization of the mammalian ERAD interaction network and the functions of its components. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535447 Thu, 22 Dec 2011 05:00:00 +0100 5535447 Shaping development with ESCRTs http://www.medworm.com/index.php?rid=5535446&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FVBgenHoN_Pk%2Fncb2381 Authors: Tor Erik Rusten, Thomas Vaccari & Harald Stenmark (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535446 Thu, 22 Dec 2011 05:00:00 +0100 5535446 Sorting nexins provide diversity for retromer-dependent trafficking events http://www.medworm.com/index.php?rid=5535445&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FGAxDN2D7v0k%2Fncb2374 Authors: Peter J. Cullen & Hendrik C. Korswagen (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535445 Thu, 22 Dec 2011 05:00:00 +0100 5535445 COPII and the regulation of protein sorting in mammals http://www.medworm.com/index.php?rid=5535444&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FzKTHYLIdXgk%2Fncb2390 Authors: Giulia Zanetti, Kanika Bajaj Pahuja, Sean Studer, Soomin Shim & Randy Schekman (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535444 Thu, 22 Dec 2011 05:00:00 +0100 5535444 Bridging membrane and cytoskeleton dynamics in the secretory and endocytic pathways http://www.medworm.com/index.php?rid=5535443&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FqBVSPrG8RK8%2Fncb2409 Authors: Mihaela Anitei & Bernard Hoflack (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535443 Thu, 22 Dec 2011 05:00:00 +0100 5535443 Lessons from yeast for clathrin-mediated endocytosis http://www.medworm.com/index.php?rid=5535442&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FI-4ek8AlJyk%2Fncb2403 Authors: Douglas R. Boettner, Richard J. Chi & Sandra K. Lemmon (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535442 Thu, 22 Dec 2011 05:00:00 +0100 5535442 Limited stay for foreign scientists in the UK? http://www.medworm.com/index.php?rid=5535441&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FTz2U_xj1tts%2Fncb2415b Nature Cell Biology 14, 1 (2012). doi:10.1038/ncb2415b New immigration proposals restricting the period of stay for highly skilled migrants in the UK could undermine the future of British science. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535441 Thu, 22 Dec 2011 05:00:00 +0100 5535441 Focus on Membrane dynamics http://www.medworm.com/index.php?rid=5535440&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FzJN1-HcDckA%2Fncb2415a Nature Cell Biology 14, 1 (2012). doi:10.1038/ncb2415a Cellular membranes in eukaryotes are dynamic structures; this is a key property for their roles in numerous cellular processes. In this issue, we present a series of review articles that highlight recent developments in membrane trafficking, and provide an overview of the importance of trafficking events in development and disease. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535440 Thu, 22 Dec 2011 05:00:00 +0100 5535440 Wnt7a–Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle http://www.medworm.com/index.php?rid=5657983&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FzXG0KDP23sw%2Fncb2404 Wnt7a–Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle Nature Cell Biology 14, 186 (2012). doi:10.1038/ncb2404 Authors: Julia von Maltzahn, C. Florian Bentzinger & Michael A. Rudnicki Wnt7a signals through its receptor Fzd7 to activate the planar-cell-polarity pathway and drive the symmetric expansion of satellite stem cells resulting in enhanced repair of skeletal muscle. In differentiated myofibres, we observed that Wnt7a binding to Fzd7 directly activates the Akt/mTOR growth pathway, thereby inducing myofibre hypertrophy. Notably, the Fzd7 receptor complex was associated with Gαs and PI(3)K and these components were required for Wnt7a to activate the Akt/mTOR growth pathway in myotubes. Wnt7a–Fzd7 activation of this... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657983 Sun, 18 Dec 2011 05:00:00 +0100 5657983 Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320 http://www.medworm.com/index.php?rid=5657980&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FBFTiIacjaDg%2Fncb2396 Authors: A. Bronisz, J. Godlewski, J. A. Wallace, A.S. Merchant, M.O. Nowicki, H. Mathsyaraja, R. Srinivasan, A. J. Trimboli, C. K. Martin, F. Li, L. Yu, S. A. Fernandez, T. Pécot, T. J. Rosol, S. Cory, M. Hallett, M. Park, M. G. Piper, C. B. Marsh, L. D. Yee, R. E. Jimenez, G. Nuovo, S. E. Lawler, E. A. Chiocca, G. Leone & M. C. Ostrowski (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657980 Sun, 18 Dec 2011 05:00:00 +0100 5657980 The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins http://www.medworm.com/index.php?rid=5657979&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FCFTw5uiBOM8%2Fncb2394 The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins Nature Cell Biology 14, 148 (2012). doi:10.1038/ncb2394 Authors: Anchal Chandra, Hernán E. Grecco, Venkat Pisupati, David Perera, Liam Cassidy, Ferdinandos Skoulidis, Shehab A. Ismail, Christian Hedberg, Michael Hanzal-Bayer, Ashok R. Venkitaraman, Alfred Wittinghofer & Philippe I. H. Bastiaens (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5657979 Sun, 18 Dec 2011 05:00:00 +0100 5657979 The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress http://www.medworm.com/index.php?rid=5535457&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FrgpJB8pHSdM%2Fncb2395 Authors: Kathryn Austgen, Emily T. Johnson, Tae-Ju Park, Tom Curran & Scott A. Oakes Excessive demands on the protein-folding capacity of the endoplasmic reticulum (ER) cause irremediable ER stress and contribute to cell loss in a number of cell degenerative diseases, including type 2 diabetes and neurodegeneration. The signals communicating catastrophic ER damage to the mitochondrial apoptotic machinery remain poorly understood. We used a biochemical approach to purify a cytosolic activity induced by ER stress that causes release of cytochrome  c from isolated mitochondria. We discovered that the principal component of the purified pro-apoptotic activity is the proto-oncoprotein CRK (CT10-regulated kinase), an adaptor protein with no known catalytic activity. Crk−/− c... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535457 Sun, 18 Dec 2011 05:00:00 +0100 5535457 A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain http://www.medworm.com/index.php?rid=5535454&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F3-HmIB8-FRo%2Fncb2410 Authors: Ben Chih, Peter Liu, Yvonne Chinn, Cecile Chalouni, Laszlo G. Komuves, Philip E. Hass, Wendy Sandoval & Andrew S. Peterson (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535454 Sun, 18 Dec 2011 05:00:00 +0100 5535454 Polarized cell growth in Arabidopsis requires endosomal recycling mediated by GBF1-related ARF exchange factors http://www.medworm.com/index.php?rid=5535456&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FQ9SLzyNI9Uw%2Fncb2389 Authors: Sandra Richter, Lena M. Müller, York-Dieter Stierhof, Ulrike Mayer, Nozomi Takada, Benedikt Kost, Anne Vieten, Niko Geldner, Csaba Koncz & Gerd Jürgens Polarized tip growth is a fundamental cellular process in many eukaryotic organisms, mediating growth of neuronal axons and dendrites or fungal hyphae. In plants, pollen and root hairs are cellular model systems for analysing tip growth. Cell growth depends on membrane traffic. The regulation of this membrane traffic is largely unknown for tip-growing cells, in contrast to cells exhibiting intercalary growth. Here we show that in Arabidopsis, GBF1-related exchange factors for the ARF GTPases (ARF GEFs) GNOM and GNL2 play essential roles in polar tip growth of root hairs and pollen, respectively. When expressed from th... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535456 Sun, 04 Dec 2011 05:00:00 +0100 5535456 Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction http://www.medworm.com/index.php?rid=5535455&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FHDNyRIAMZSo%2Fncb2388 Authors: Tobias Sperka, Zhangfa Song, Yohei Morita, Kodandaramireddy Nalapareddy, Luis Miguel Guachalla, André Lechel, Yvonne Begus-Nahrmann, Martin D. Burkhalter, Monika Mach, Falk Schlaudraff, Birgit Liss, Zhenyu Ju, Michael R. Speicher & K. Lenhard Rudolph The tumour suppressor p53 activates Puma-dependent apoptosis and p21-dependent cell-cycle arrest in response to DNA damage. Deletion of p21 improved stem-cell function and organ maintenance in progeroid mice with dysfunctional telomeres, but the function of Puma has not been investigated in this context. Here we show that deletion of Puma improves stem- and progenitor-cell function, organ maintenance and lifespan of telomere-dysfunctional mice. Puma deletion impairs the clearance of stem and progenitor cells that have accumul... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535455 Sun, 04 Dec 2011 05:00:00 +0100 5535455 Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling http://www.medworm.com/index.php?rid=5535453&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FHWCYDfvjujk%2Fncb2386 Authors: Emma Sandilands, Bryan Serrels, David G. McEwan, Jennifer P. Morton, Juan Pablo Macagno, Kenneth McLeod, Craig Stevens, Valerie G. Brunton, Wallace Y. Langdon, Marcos Vidal, Owen J. Sansom, Ivan Dikic, Simon Wilkinson & Margaret C. Frame (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535453 Sun, 04 Dec 2011 05:00:00 +0100 5535453 Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity http://www.medworm.com/index.php?rid=5466794&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FKuzy4eaVslg%2Fncb2405 Nature Cell Biology 13, 1467 (2011). doi:10.1038/ncb2405 Author: Tse-Chun Kuo, Chun-Ting Chen, Desiree Baron, Tamer T. Onder, Sabine Loewer, Sandra Almeida, Cara M. Weismann, Ping Xu, Jean-Marie Houghton, Fen-Biao Gao, George Q. Daley & Stephen Doxsey (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466794 Thu, 01 Dec 2011 05:00:00 +0100 5466794 p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs http://www.medworm.com/index.php?rid=5466793&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FZdtii9eXxmM%2Fncb2402 p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs Nature Cell Biology 13, 1467 (2011). doi:10.1038/ncb2402 Author: Chun-Ju Chang, Chi-Hong Chao, Weiya Xia, Jer-Yen Yang, Yan Xiong, Chia-Wei Li, Wen-Hsuan Yu, Sumaiyah K. Rehman, Jennifer L. Hsu, Heng-Huan Lee, Mo Liu, Chun-Te Chen, Dihua Yu & Mien-Chie Hung (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466793 Thu, 01 Dec 2011 05:00:00 +0100 5466793 Autophagy clears dad's mitochondria http://www.medworm.com/index.php?rid=5466782&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FqffdinIsni0%2Fncb2400 Nature Cell Biology 13, 1394 (2011). doi:10.1038/ncb2400 Author: Christina Karlsson Rosenthal (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466782 Thu, 01 Dec 2011 05:00:00 +0100 5466782 Hair follicles run by clockwork http://www.medworm.com/index.php?rid=5466781&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FJDCkU9-xs68%2Fncb2399 Nature Cell Biology 13, 1394 (2011). doi:10.1038/ncb2399 Author: Nathalie Le Bot (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466781 Thu, 01 Dec 2011 05:00:00 +0100 5466781 Mapping the mitochondria http://www.medworm.com/index.php?rid=5466780&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FlesQ7UFtB1s%2Fncb2398 Nature Cell Biology 13, 1394 (2011). doi:10.1038/ncb2398 Author: Emily J. Chenette (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466780 Thu, 01 Dec 2011 05:00:00 +0100 5466780 Yap makes the heart grow http://www.medworm.com/index.php?rid=5466779&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FOtCt9HtA80g%2Fncb2397 Nature Cell Biology 13, 1394 (2011). doi:10.1038/ncb2397 Author: Emily J. Chenette (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466779 Thu, 01 Dec 2011 05:00:00 +0100 5466779 Pulling together and pulling apart: collective cargo movement in eukaryotic cells http://www.medworm.com/index.php?rid=5466778&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FWc2FteUpT3Q%2Fncb2393 Nature Cell Biology 13, 1391 (2011). doi:10.1038/ncb2393 Author: Dyche Mullins To establish and maintain their internal organization, living cells must move molecules to their correct locations. Long-range intracellular movements are often driven by motor molecules moving along microtubules, similarly to trucks driving along a highway. Recent work demonstrates that some randomly dispersed cargos can generate actin filaments that form a connected network whose contraction drives collective cargo movement. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466778 Thu, 01 Dec 2011 05:00:00 +0100 5466778 Phosphatidylserine promotes polar Cdc42 localization http://www.medworm.com/index.php?rid=5466776&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FGPC-WDJXmFA%2Fncb2382 Authors: Tina Freisinger & Roland Wedlich-Söldner The establishment and maintenance of cell polarity requires targeted recruitment of polarity regulators to the plasma membrane. Phosphatidylserine is now shown to have a key role in polarization of yeast cells and the localization of the central polarity regulator Cdc42. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466776 Thu, 01 Dec 2011 05:00:00 +0100 5466776 Heeding a mentor's advice: A lesson in persistence http://www.medworm.com/index.php?rid=5466775&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FeaWuASPPqi4%2Fncb2392 Nature Cell Biology 13, 1386 (2011). doi:10.1038/ncb2392 Author: Mina J. Bissell (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466775 Thu, 01 Dec 2011 05:00:00 +0100 5466775 Cell biology in India: The future needs an international perspective http://www.medworm.com/index.php?rid=5466774&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FEBr0j5Coahs%2Fncb2391 Nature Cell Biology 13, 1385 (2011). doi:10.1038/ncb2391 Author: Satyajit Mayor There is a lack of trained scientists to fill the increasing number of jobs and funding opportunities in the Indian scientific research sector. This is a great opportunity for the international scientific community to help build and nurture a vibrant cell biology research community in India. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466774 Thu, 01 Dec 2011 05:00:00 +0100 5466774 Single-molecule transcript counting of stem-cell markers in the mouse intestine http://www.medworm.com/index.php?rid=5535459&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FDjueHpl72T0%2Fncb2384 Authors: Shalev Itzkovitz, Anna Lyubimova, Irene C. Blat, Mindy Maynard, Johan van Es, Jacqueline Lees, Tyler Jacks, Hans Clevers & Alexander van Oudenaarden (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535459 Sun, 27 Nov 2011 05:00:00 +0100 5535459 Defining human ERAD networks through an integrative mapping strategy http://www.medworm.com/index.php?rid=5535458&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FhLClZecFB6Y%2Fncb2383 Authors: John C. Christianson, James A. Olzmann, Thomas A. Shaler, Mathew E. Sowa, Eric J. Bennett, Caleb M. Richter, Ryan E. Tyler, Ethan J. Greenblatt, J. Wade Harper & Ron R. Kopito (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535458 Sun, 27 Nov 2011 05:00:00 +0100 5535458 The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis http://www.medworm.com/index.php?rid=5466783&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fc4jAFsyvAmE%2Fncb2385 Authors: Elisabete M. Nascimento, Claire L. Cox, Stewart MacArthur, Shobbir Hussain, Matthew Trotter, Sandra Blanco, Menon Suraj, Jennifer Nichols, Bernd Kübler, Salvador Aznar Benitah, Brian Hendrich, Duncan T. Odom & Michaela Frye (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466783 Sun, 20 Nov 2011 05:00:00 +0100 5466783 Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing http://www.medworm.com/index.php?rid=5466791&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FUTtcRFagqzE%2Fncb2370 Authors: Masha Prager-Khoutorsky, Alexandra Lichtenstein, Ramaswamy Krishnan, Kavitha Rajendran, Avi Mayo, Zvi Kam, Benjamin Geiger & Alexander D. Bershadsky (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466791 Sun, 13 Nov 2011 05:00:00 +0100 5466791 K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assembly http://www.medworm.com/index.php?rid=5466784&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FCxI1lDu3nYc%2Fncb2372 Authors: Sylvain Meunier & Isabelle Vernos (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466784 Sun, 13 Nov 2011 05:00:00 +0100 5466784 A new cap for kinetochore fibre minus ends http://www.medworm.com/index.php?rid=5466777&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F2C0Db-0KgmE%2Fncb2387 Authors: Sabine Petry & Ronald D. Vale In mitotic spindles, each sister chromatid is directly attached to a spindle pole through microtubule bundles known as kinetochore fibres. Microspherule protein 1 (MCRS1) is now shown to support spindle assembly by localizing to the minus ends of kinetochore fibres and protecting them from depolymerization. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466777 Sun, 13 Nov 2011 05:00:00 +0100 5466777 ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation http://www.medworm.com/index.php?rid=5466785&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FWrZKyUNdDug%2Fncb2373 Authors: Shuji Wakatsuki, Fuminori Saitoh & Toshiyuki Araki (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466785 Sun, 06 Nov 2011 04:00:00 +0100 5466785 Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase http://www.medworm.com/index.php?rid=5378321&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fxd4ndZ2XC8I%2Fncb2369 Nature Cell Biology 13, 1383 (2011). doi:10.1038/ncb2369 Author: Kambiz N. Alavian, Hongmei Li, Leon Collis, Laura Bonanni, Lu Zeng, Silvio Sacchetti, Emma Lazrove, Panah Nabili, Benjamin Flaherty, Morven Graham, Yingbei Chen, Shanta M. Messerli, Maria A. Mariggio, Christoph Rahner, Ewan McNay, Gordon C. Shore, Peter J. S. Smith, J. Marie Hardwick & Elizabeth A. Jonas (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378321 Wed, 02 Nov 2011 04:00:00 +0100 5378321 Regulating metastasis: The two faces of miR-200 http://www.medworm.com/index.php?rid=5378310&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FFbcdhYWoIcY%2Fncb2379 Nature Cell Biology 13, 1294 (2011). doi:10.1038/ncb2379 Author: Alexia-IIeana Zaromytidou (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378310 Wed, 02 Nov 2011 04:00:00 +0100 5378310 Mammary gland stem cells http://www.medworm.com/index.php?rid=5378309&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fplazn-0w_jQ%2Fncb2378 Nature Cell Biology 13, 1294 (2011). doi:10.1038/ncb2378 Author: Nathalie Le Bot (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378309 Wed, 02 Nov 2011 04:00:00 +0100 5378309 Cytoskeleton links to ciliary organization http://www.medworm.com/index.php?rid=5378308&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F6z-yo6ckgxs%2Fncb2377 Nature Cell Biology 13, 1294 (2011). doi:10.1038/ncb2377 Author: Emily J. Chenette (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378308 Wed, 02 Nov 2011 04:00:00 +0100 5378308 Ubiquitinomics http://www.medworm.com/index.php?rid=5378307&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FZX5EnNAyRUE%2Fncb2376 Nature Cell Biology 13, 1294 (2011). doi:10.1038/ncb2376 Author: Christina Karlsson Rosenthal (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378307 Wed, 02 Nov 2011 04:00:00 +0100 5378307 SHARPINing integrin inhibition http://www.medworm.com/index.php?rid=5378306&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F7dGQ6N7C_oc%2Fncb2368 Nature Cell Biology 13, 1292 (2011). doi:10.1038/ncb2368 Author: Mark D. Bass The activity state of integrins is crucial for cell adhesion, migration and differentiation, and is regulated predominantly by protein interactions of the integrin β cytoplasmic domain. SHARPIN is now shown to negatively regulate integrin activation by binding the α-integrin subunit and interfering with the association of the β cytodomain with activating proteins. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378306 Wed, 02 Nov 2011 04:00:00 +0100 5378306 Nuclear actin and myosins: Life without filaments http://www.medworm.com/index.php?rid=5378304&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F8IVJSSZmmc8%2Fncb2364 Authors: Primal de Lanerolle & Leonid Serebryannyy (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378304 Wed, 02 Nov 2011 04:00:00 +0100 5378304 NCB tweets http://www.medworm.com/index.php?rid=5378303&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F3a1mwMhFiIs%2Fncb2375b Nature Cell Biology 13, 1281 (2011). doi:10.1038/ncb2375b Nature Cell Biology editors highlight research and news relevant to cell and developmental biologists. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378303 Wed, 02 Nov 2011 04:00:00 +0100 5378303 Scientific communication: Writing up http://www.medworm.com/index.php?rid=5378302&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FwT-kCrTodA8%2Fncb2375a Nature Cell Biology 13, 1281 (2011). doi:10.1038/ncb2375a In the competitive world of scientific publishing, it is essential to communicate research findings in a clear and accessible manner. Scientists should develop the ability to write well-structured and compelling cover letters, manuscripts and rebuttal letters. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378302 Wed, 02 Nov 2011 04:00:00 +0100 5378302 Caspase 8 inhibits programmed necrosis by processing CYLD http://www.medworm.com/index.php?rid=5466788&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FOfhEEET2vow%2Fncb2362 Authors: Marie Anne O’Donnell, Eva Perez-Jimenez, Andrew Oberst, Aylwin Ng, Ramin Massoumi, Ramnik Xavier, Douglas R. Green & Adrian T. Ting Caspase 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and processing the executioner caspase 3 (ref. ). However, the dominant function of caspase 8 is to transmit a pro-survival signal that suppresses programmed necrosis (or necroptosis) mediated by RIPK1 and RIPK3 (refs , , , , ) during embryogenesis and haematopoiesis. Suppression of necrotic cell death by caspase 8 requires its catalytic activity but not the autocleavage essential for apoptosis; however, the key substrate processed by caspase 8 to block necrosis has been elusive. A key substrate must meet three criteria: it must be essential ... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466788 Sun, 30 Oct 2011 04:00:00 +0100 5466788 Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription http://www.medworm.com/index.php?rid=5466790&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FuJuwhBxOLIs%2Fncb2365 Authors: Andres Clemente-Blanco, Nicholas Sen, Maria Mayan-Santos, Maria P. Sacristán, Bryony Graham, Adam Jarmuz, Adam Giess, Elizabeth Webb, Laurence Game, Dirk Eick, Avelino Bueno, Matthias Merkenschlager & Luis Aragón Kinases and phosphatases regulate messenger RNA synthesis through post-translational modification of the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II (ref. ). In yeast, the phosphatase Cdc14 is required for mitotic exit and for segregation of repetitive regions. Cdc14 is also a subunit of the silencing complex RENT (refs , ), but no roles in transcriptional repression have been described. Here we report that inactivation of Cdc14 causes silencing defects at the intergenic spacer sequences of ribosomal genes during inter... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466790 Sun, 23 Oct 2011 04:00:00 +0100 5466790 E-box-independent regulation of transcription and differentiation by MYC http://www.medworm.com/index.php?rid=5466789&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FAi8YWUuuZc8%2Fncb2355 Authors: Iris Uribesalgo, Marcus Buschbeck, Arantxa Gutiérrez, Sophia Teichmann, Santiago Demajo, Bernd Kuebler, Josep F. Nomdedéu, Juan Martín-Caballero, Guglielmo Roma, Salvador Aznar Benitah & Luciano Di Croce MYC proto-oncogene is a key player in cell homeostasis that is commonly deregulated in human carcinogenesis. MYC can either activate or repress target genes by forming a complex with MAX (ref. ). MYC also exerts MAX-independent functions that are not yet fully characterized. Cells possess an intrinsic pathway that can abrogate MYC–MAX dimerization and E-box interaction, by inducing phosphorylation of MYC in a PAK2-dependent manner at three residues located in its helix–loop–helix domain. Here we show that these carboxy-terminal phosphoryla... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466789 Sun, 23 Oct 2011 04:00:00 +0100 5466789 The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks http://www.medworm.com/index.php?rid=5378320&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FK8SAMwSgZyk%2Fncb2367 Authors: Mayura Meerang, Danilo Ritz, Shreya Paliwal, Zuzana Garajova, Matthias Bosshard, Niels Mailand, Pavel Janscak, Ulrich Hübscher, Hemmo Meyer & Kristijan Ramadan Unrepaired DNA double-strand breaks (DSBs) cause genetic instability that leads to malignant transformation or cell death. Cells respond to DSBs with the ordered recruitment of signalling and repair proteins to the site of lesion. Protein modification with ubiquitin is crucial for the signalling cascade, but how ubiquitylation coordinates the dynamic assembly of these complexes is poorly understood. Here, we show that the human ubiquitin-selective protein segregase p97 (also known as VCP; valosin-containing protein) cooperates with the ubiquitin ligase RNF8 to orchestrate assembly of signalling complexes and effici... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378320 Sun, 23 Oct 2011 04:00:00 +0100 5378320 miR-34 miRNAs provide a barrier for somatic cell reprogramming http://www.medworm.com/index.php?rid=5378317&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FEQPSzaApc8A%2Fncb2366 Authors: Yong Jin Choi, Chao-Po Lin, Jaclyn J. Ho, Xingyue He, Nobuhiro Okada, Pengcheng Bu, Yingchao Zhong, Sang Yong Kim, Margaux J. Bennett, Caifu Chen, Arzu Ozturk, Geoffrey G. Hicks, Greg J. Hannon & Lin He Somatic reprogramming induced by defined transcription factors is a low-efficiency process that is enhanced by p53 deficiency. So far, p21 is the only p53 target shown to contribute to p53 repression of iPSC (induced pluripotent stem cell) generation, indicating that additional p53 targets may regulate this process. Here, we demonstrate that miR-34 microRNAs (miRNAs), particularly miR-34a, exhibit p53-dependent induction during reprogramming. Mir34a deficiency in mice significantly increased reprogramming efficiency and kinetics, with miR-34a and p21 cooperatively regulating so... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378317 Sun, 23 Oct 2011 04:00:00 +0100 5378317 Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes http://www.medworm.com/index.php?rid=5378315&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F-f-BzHqss58%2Fncb2363 Authors: Oliver Florey, Sung Eun Kim, Cynthia P. Sandoval, Cole M. Haynes & Michael Overholtzer (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378315 Sun, 16 Oct 2011 04:00:00 +0100 5378315 An actin-dependent mechanism for long-range vesicle transport http://www.medworm.com/index.php?rid=5466787&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FfoIajL-12Dc%2Fncb2353 This study reveals an unexpected actin-dependent but microtubule-independent mechanism for long-range transport of vesicles. Vesicles organize their own actin tracks by recruiting the actin nucleation factors Spire1, Spire2 and Formin-2, which assemble an extensive actin network from the vesicles’ surfaces. The network connects the vesicles with one another and with the plasma membrane. Vesicles move directionally along these connections in a myosin-Vb-dependent manner to converge and to reach the cell surface. The overall outward-directed movement of the vesicle-actin network is driven by recruitment of vesicles to the plasma membrane in the periphery of the oocyte. Being organized in a dynamic vesicle-actin network allows vesicles to move in a local random manner and a global direc... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466787 Sun, 09 Oct 2011 04:00:00 +0100 5466787 Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes http://www.medworm.com/index.php?rid=5378318&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FLR-St3SICoY%2Fncb2354 Authors: Fumio Motegi, Seth Zonies, Yingsong Hao, Adrian A. Cuenca, Erik Griffin & Geraldine Seydoux A hallmark of polarized cells is the segregation of the PAR polarity regulators into asymmetric domains at the cell cortex. Antagonistic interactions involving two conserved kinases, atypical protein kinase C (aPKC) and PAR-1, have been implicated in polarity maintenance, but the mechanisms that initiate the formation of asymmetric PAR domains are not understood. Here, we describe one pathway used by the sperm-donated centrosome to polarize the PAR proteins in Caenorhabditis elegans zygotes. Before polarization, cortical aPKC excludes PAR-1 kinase and its binding partner PAR-2 by phosphorylation. During symmetry breaking, microtubules nucleated by the centrosome locally protect PAR-2 fr... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378318 Sun, 09 Oct 2011 04:00:00 +0100 5378318 Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins http://www.medworm.com/index.php?rid=5378316&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FKrbv_Th8F10%2Fncb2343 Authors: Nancy N. Fang, Alex H. M. Ng, Vivien Measday & Thibault Mayor (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378316 Sun, 09 Oct 2011 04:00:00 +0100 5378316 Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation http://www.medworm.com/index.php?rid=5378311&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fgc5h1Of4p7U%2Fncb2341 Authors: Rui Zhao, Tetsuya Nakamura, Yu Fu, Zsolt Lazar & David L. Spector (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378311 Sun, 09 Oct 2011 04:00:00 +0100 5378311 Misfolded proteins driven to destruction by Hul5 http://www.medworm.com/index.php?rid=5378305&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FKqkM6E5etFo%2Fncb2371 Nature Cell Biology 13, 1290 (2011). doi:10.1038/ncb2371 Author: Daniel Finley Misfolded proteins are potentially toxic and are therefore subjected to highly selective degradation by the ubiquitin–proteasome system. The identification of the Hul5 ubiquitin ligase as a major mediator of such 'quality-control' ubiquitylation following heat shock raises new questions about the design of these pathways. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378305 Sun, 09 Oct 2011 04:00:00 +0100 5378305 Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway http://www.medworm.com/index.php?rid=5282903&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FaoAbcLSFzgk%2Fncb2358 Nature Cell Biology 13, 1280 (2011). doi:10.1038/ncb2358 Author: Brice Marcet, Benoît Chevalier, Guillaume Luxardi, Christelle Coraux, Laure-Emmanuelle Zaragosi, Marie Cibois, Karine Robbe-Sermesant, Thomas Jolly, Bruno Cardinaud, Chimène Moreilhon, Lisa Giovannini-Chami, Béatrice Nawrocki-Raby, Philippe Birembaut, Rainer Waldmann, Laurent Kodjabachian & Pascal Barbry (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282903 Mon, 03 Oct 2011 04:00:00 +0100 5282903 Tumour microenvironment: Cytokines signal for invasion http://www.medworm.com/index.php?rid=5282892&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FmGTXAAv0nj0%2Fncb2360 Nature Cell Biology 13, 1188 (2011). doi:10.1038/ncb2360 Author: Alexia-IIeana Zaromytidou (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282892 Mon, 03 Oct 2011 04:00:00 +0100 5282892 Coordinating cell cycle with neurogenesis http://www.medworm.com/index.php?rid=5282891&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FSKz8PpuAwIk%2Fncb2356 Nature Cell Biology 13, 1188 (2011). doi:10.1038/ncb2356 Author: Gary Dorken (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282891 Mon, 03 Oct 2011 04:00:00 +0100 5282891 Sticking to the TCA cycle http://www.medworm.com/index.php?rid=5282890&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FUioXovskNDs%2Fncb2361 Nature Cell Biology 13, 1188 (2011). doi:10.1038/ncb2361 Author: Emily J. Chenette (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282890 Mon, 03 Oct 2011 04:00:00 +0100 5282890 Mitochondrial fission: ER marks the spot http://www.medworm.com/index.php?rid=5282889&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FuDjKClHHIc0%2Fncb2359 Nature Cell Biology 13, 1188 (2011). doi:10.1038/ncb2359 Author: Emily J. Chenette (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282889 Mon, 03 Oct 2011 04:00:00 +0100 5282889 Spindle positioning: going against the actin flow http://www.medworm.com/index.php?rid=5282887&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FLMBTy3ZMVuY%2Fncb2352 Nature Cell Biology 13, 1183 (2011). doi:10.1038/ncb2352 Author: Marie-Hélène Verlhac Successful completion of meiosis in vertebrate oocytes requires the localization and maintenance of the meiotic spindle at the cell cortex. Arp2/3-nucleated actin filaments are now shown to flow away from the cortex overlying the spindle, resulting in cytoplasmic streaming, which maintains the spindle in its asymmetric position. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282887 Mon, 03 Oct 2011 04:00:00 +0100 5282887 A brief history of error http://www.medworm.com/index.php?rid=5282886&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Ff6GnIPZ2uSE%2Fncb2348 Nature Cell Biology 13, 1178 (2011). doi:10.1038/ncb2348 Author: Andrew W. Murray (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282886 Mon, 03 Oct 2011 04:00:00 +0100 5282886 Cohesin: a catenase with separate entry and exit gates? http://www.medworm.com/index.php?rid=5282885&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FGcR0smpUVuE%2Fncb2349 Nature Cell Biology 13, 1170 (2011). doi:10.1038/ncb2349 Author: Kim Nasmyth (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282885 Mon, 03 Oct 2011 04:00:00 +0100 5282885 More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance http://www.medworm.com/index.php?rid=5282884&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FhWJj8CDdywQ%2Fncb2344 Authors: Jiri Lukas, Claudia Lukas & Jiri Bartek (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282884 Mon, 03 Oct 2011 04:00:00 +0100 5282884 The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries http://www.medworm.com/index.php?rid=5282883&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FlaGT4Ypku_Q%2Fncb2345 Authors: Erich A. Nigg & Tim Stearns (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282883 Mon, 03 Oct 2011 04:00:00 +0100 5282883 UK Parliament comments on peer review http://www.medworm.com/index.php?rid=5282882&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FABBbE_Lg-_w%2Fncb2357b Nature Cell Biology 13, 1153 (2011). doi:10.1038/ncb2357b Recognizing the importance of sound scientific advice to the government, the UK Parliament has examined the peer review system. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282882 Mon, 03 Oct 2011 04:00:00 +0100 5282882 Focus on Cell cycle and DNA damage http://www.medworm.com/index.php?rid=5282881&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FCybdtMWz6pI%2Fncb2357a Nature Cell Biology 13, 1153 (2011). doi:10.1038/ncb2357a How cells accurately duplicate and segregate their genetic information remains a topic of intense research. A series of specially commissioned articles in this issue presents recent insights into different aspects of the cell division cycle and genomic surveillance. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282881 Mon, 03 Oct 2011 04:00:00 +0100 5282881 Phosphatidylserine is polarized and required for proper Cdc42 localization and for development of cell polarity http://www.medworm.com/index.php?rid=5466786&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FQ5bS0szae4M%2Fncb2351 Authors: Gregory D. Fairn, Martin Hermansson, Pentti Somerharju & Sergio Grinstein Polarity is key to the function of eukaryotic cells. On the establishment of a polarity axis, cells can vectorially target secretion, generating an asymmetric distribution of plasma membrane proteins. From Saccharomyces cerevisiae to mammals, the small GTPase Cdc42 is a pivotal regulator of polarity. We used a fluorescent probe to visualize the distribution of phosphatidylserine in live S. cerevisiae. Remarkably, phosphatidylserine was polarized in the plasma membrane, accumulating in bud necks, the bud cortex and the tips of mating projections. Polarization required vectorial delivery of phosphatidylserine-containing secretory vesicles, and phosphatidylserine was largely excluded from endocytic vesicles... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5466786 Sun, 02 Oct 2011 04:00:00 +0100 5466786 USP15 is a deubiquitylating enzyme for receptor-activated SMADs http://www.medworm.com/index.php?rid=5378319&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fu8l517RglHg%2Fncb2346 Authors: Masafumi Inui, Andrea Manfrin, Anant Mamidi, Graziano Martello, Leonardo Morsut, Sandra Soligo, Elena Enzo, Stefano Moro, Simona Polo, Sirio Dupont, Michelangelo Cordenonsi & Stefano Piccolo The TGFβ pathway is critical for embryonic development and adult tissue homeostasis. On ligand stimulation, TGFβ and BMP receptors phosphorylate receptor-activated SMADs (R-SMADs), which then associate with SMAD4 to form a transcriptional complex that regulates gene expression through specific DNA recognition. Several ubiquitin ligases serve as inhibitors of R-SMADs, yet no deubiquitylating enzyme (DUB) for these molecules has so far been identified. This has left unexplored the possibility that ubiquitylation of R-SMADs is reversible and engaged in regulating SMAD function, in a... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378319 Sun, 25 Sep 2011 04:00:00 +0100 5378319 MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1–Cdc25 pathway http://www.medworm.com/index.php?rid=5378314&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F_xL3D4HCQts%2Fncb2342 MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1–Cdc25 pathway Nature Cell Biology 13, 1325 (2011). doi:10.1038/ncb2342 Authors: Ralph Gruber, Zhongwei Zhou, Mikhail Sukchev, Tjard Joerss, Pierre-Olivier Frappart & Zhao-Qi Wang (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378314 Sun, 25 Sep 2011 04:00:00 +0100 5378314 SHARPIN is an endogenous inhibitor of β1-integrin activation http://www.medworm.com/index.php?rid=5378313&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fnd3Z0siZfwk%2Fncb2340 SHARPIN is an endogenous inhibitor of β1-integrin activation Nature Cell Biology 13, 1315 (2011). doi:10.1038/ncb2340 Authors: Juha K. Rantala, Jeroen Pouwels, Teijo Pellinen, Stefan Veltel, Petra Laasola, Elina Mattila, Christopher S. Potter, Ted Duffy, John P. Sundberg, Olli Kallioniemi, Janet A. Askari, Martin J. Humphries, Maddy Parsons, Marko Salmi & Johanna Ivaska (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378313 Sun, 25 Sep 2011 04:00:00 +0100 5378313 BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol http://www.medworm.com/index.php?rid=5378312&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FevsbAe4_LRg%2Fncb2339 Authors: Roger Geiger, Daniel Andritschke, Sarah Friebe, Fabian Herzog, Stefania Luisoni, Thomas Heger & Ari Helenius (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5378312 Sun, 25 Sep 2011 04:00:00 +0100 5378312 APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment http://www.medworm.com/index.php?rid=5282897&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FHPw45b6B3VM%2Fncb2347 Authors: Jörg Mansfeld, Philippe Collin, Mark O. Collins, Jyoti S. Choudhary & Jonathon Pines (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282897 Sun, 18 Sep 2011 04:00:00 +0100 5282897 Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase http://www.medworm.com/index.php?rid=5282896&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F9zNhgnj_J3Q%2Fncb2330 Authors: Kambiz N. Alavian, Hongmei Li, Leon Collis, Laura Bonanni, Lu Zeng, Silvio Sacchetti, Emma Lazrove, Panah Nabili, Benjamin Flaherty, Morven Graham, Yingbei Chen, Shanta M. Messerli, Maria A. Mariggio, Christoph Rahner, Ewan McNay, Gordon C. Shore, Peter J. S. Smith, J. Marie Hardwick & Elizabeth A. Jonas (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282896 Sun, 18 Sep 2011 04:00:00 +0100 5282896 Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis http://www.medworm.com/index.php?rid=5282893&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fti0KvjhyWx0%2Fncb2328 Authors: Hongjie Zhang, Nessy Abraham, Liakot A. Khan, David H. Hall, John T. Fleming & Verena Göbel (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282893 Sun, 18 Sep 2011 04:00:00 +0100 5282893 Making sense of glycosphingolipids in epithelial polarity http://www.medworm.com/index.php?rid=5282888&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F2Zjv7ONxB5k%2Fncb2350 Authors: Vincent Hyenne & Michel Labouesse A potential role for glycosphingolipids and lipid rafts in apical sorting was initially met with enthusiasm, but genetic analysis has since provided little support for it. A report now establishes that glycosphingolipids mediate apical sorting, and specifically help maintain apicobasal polarity in Caenorhabditis elegans. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282888 Sun, 18 Sep 2011 04:00:00 +0100 5282888 Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity http://www.medworm.com/index.php?rid=5282895&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F6-cvhNX2ib0%2Fncb2332 Authors: Tse-Chun Kuo, Chun-Ting Chen, Desiree Baron, Tamer T. Onder, Sabine Loewer, Sandra Almeida, Cara M. Weismann, Ping Xu, Jean-Marie Houghton, Fen-Biao Gao, George Q. Daley & Stephen Doxsey (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282895 Sun, 11 Sep 2011 04:00:00 +0100 5282895 VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling http://www.medworm.com/index.php?rid=5282894&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F-vM-7tq3PbQ%2Fncb2331 Authors: Tuomas Tammela, Georgia Zarkada, Harri Nurmi, Lars Jakobsson, Krista Heinolainen, Denis Tvorogov, Wei Zheng, Claudio A. Franco, Aino Murtomäki, Evelyn Aranda, Naoyuki Miura, Seppo Ylä-Herttuala, Marcus Fruttiger, Taija Mäkinen, Anne Eichmann, Jeffrey W. Pollard, Holger Gerhardt & Kari Alitalo (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282894 Sun, 11 Sep 2011 04:00:00 +0100 5282894 Adaptive braking by Ase1 prevents overlapping microtubules from sliding completely apart http://www.medworm.com/index.php?rid=5282900&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FYafXe59omJ8%2Fncb2323 Authors: Marcus Braun, Zdenek Lansky, Gero Fink, Felix Ruhnow, Stefan Diez & Marcel E. Janson Short regions of overlap between ends of antiparallel microtubules are central elements within bipolar microtubule arrays. Although their formation requires motors, recent in vitro studies demonstrated that stable overlaps cannot be generated by molecular motors alone. Motors either slide microtubules along each other until complete separation or, in the presence of opposing motors, generate oscillatory movements. Here, we show that Ase1, a member of the conserved MAP65/PRC1 family of microtubule-bundling proteins, enables the formation of stable antiparallel overlaps through adaptive braking of Kinesin-14-driven microtubule–microtubule sliding. As overlapping microtubules start to slide... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282900 Sun, 04 Sep 2011 04:00:00 +0100 5282900 Akt-ing to control lipid metabolism http://www.medworm.com/index.php?rid=5181216&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fboi35s8Bn2o%2Fncb2337 Nature Cell Biology 13, 1028 (2011). doi:10.1038/ncb2337 Author: Alexia-IIeana Zaromytidou (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181216 Thu, 01 Sep 2011 23:00:00 +0100 5181216 TALEs from the genetic engineering of stem cells http://www.medworm.com/index.php?rid=5181215&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FqfF3YBzbyNg%2Fncb2335 Nature Cell Biology 13, 1028 (2011). doi:10.1038/ncb2335 Author: Nathalie Le Bot (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181215 Thu, 01 Sep 2011 23:00:00 +0100 5181215 This way up: Septins guide microtubules http://www.medworm.com/index.php?rid=5181214&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FScx9OpS58-4%2Fncb2336 Nature Cell Biology 13, 1028 (2011). doi:10.1038/ncb2336 Author: Gary Dorken (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181214 Thu, 01 Sep 2011 23:00:00 +0100 5181214 SNARE proteins regulate autophagosome biogenesis http://www.medworm.com/index.php?rid=5181213&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fh4_DQS4O6xg%2Fncb2338 Nature Cell Biology 13, 1028 (2011). doi:10.1038/ncb2338 Author: Emily J. Chenette (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181213 Thu, 01 Sep 2011 23:00:00 +0100 5181213 Coupling mitochondrial and cell division http://www.medworm.com/index.php?rid=5181212&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FN7auxtMYUiY%2Fncb2334 Authors: Koji Yamano & Richard J. Youle The mitochondrial network fragments during mitosis to allow proper segregation of the organelles between daughter cells. Two mitotic kinases, the cyclin B–CDK1 complex and Aurora A, are now shown to cooperate with the small G protein RALA and its effector RALBP1 to promote DRP1 phosphorylation and mitochondrial fission. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181212 Thu, 01 Sep 2011 23:00:00 +0100 5181212 Wnt: What's Needed To maintain pluripotency? http://www.medworm.com/index.php?rid=5181211&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F_Yeark9ZPIQ%2Fncb2333 Nature Cell Biology 13, 1024 (2011). doi:10.1038/ncb2333 Author: Hitoshi Niwa A precise role for the canonical Wnt pathway in maintaining pluripotency in mouse embryonic stem cells (mESCs) has been debated. Four recent reports add pieces to the puzzle and together these results may help establish a robust model. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181211 Thu, 01 Sep 2011 23:00:00 +0100 5181211 The AMPK signalling pathway coordinates cell growth, autophagy and metabolism http://www.medworm.com/index.php?rid=5181210&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FUXCCaW6-hMA%2Fncb2329 Authors: Maria M. Mihaylova & Reuben J. Shaw (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181210 Thu, 01 Sep 2011 23:00:00 +0100 5181210 Reply: Visualizing branched actin filaments in lamellipodia by electron tomography http://www.medworm.com/index.php?rid=5181209&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FXLQ5ndEzR7k%2Fncb2322 Authors: J. Victor Small, Christoph Winkler, Marlene Vinzenz & Christian Schmeiser (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181209 Thu, 01 Sep 2011 23:00:00 +0100 5181209 Visualizing branched actin filaments in lamellipodia by electron tomography http://www.medworm.com/index.php?rid=5181208&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F9NSBDTs_8Dw%2Fncb2321 Authors: Changsong Yang & Tatyana Svitkina (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181208 Thu, 01 Sep 2011 23:00:00 +0100 5181208 What's wrong with correlative experiments? http://www.medworm.com/index.php?rid=5181207&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FeHPfpL7ZbOU%2Fncb2325 Authors: Marco Vilela & Gaudenz Danuser Here, we make a case for multivariate measurements in cell biology with minimal perturbation. We discuss how correlative data can identify cause-effect relationships in cellular pathways with potentially greater accuracy than conventional perturbation studies. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181207 Thu, 01 Sep 2011 23:00:00 +0100 5181207 NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration http://www.medworm.com/index.php?rid=5282902&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Ff-h0nK2WSBI%2Fncb2324 NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration Nature Cell Biology 13, 1272 (2011). doi:10.1038/ncb2324 Authors: Claudio Mauro, Shi Chi Leow, Elena Anso, Sonia Rocha, Anil K. Thotakura, Laura Tornatore, Marta Moretti, Enrico De Smaele, Amer A. Beg, Vinay Tergaonkar, Navdeep S. Chandel & Guido Franzoso Cell proliferation is a metabolically demanding process. It requires active reprogramming of cellular bioenergetic pathways towards glucose metabolism to support anabolic growth. NF-κB/Rel transcription factors coordinate many of the signals that drive proliferation during immunity, inflammation and oncogenesis, but whether NF-κB regulates the metabolic reprogramming required for cell division during these proce... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282902 Sun, 28 Aug 2011 04:00:00 +0100 5282902 Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase http://www.medworm.com/index.php?rid=5282901&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FOw78-ek6Kuc%2Fncb2327 Authors: Emily A. Foley, Maria Maldonado & Tarun M. Kapoor Error-free chromosome segregation depends on the precise regulation of phosphorylation to stabilize kinetochore–microtubule attachments (K-fibres) on sister chromatids that have attached to opposite spindle poles (bi-oriented). In many instances, phosphorylation correlates with K-fibre destabilization. Consistent with this, multiple kinases, including Aurora B and Plk1, are enriched at kinetochores of mal-oriented chromosomes when compared with bi-oriented chromosomes, which have stable attachments. Paradoxically, however, these kinases also target to prometaphase chromosomes that have not yet established spindle attachments and it is therefore unclear how kinetochore–microtubule interactions can be stabilized when ... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282901 Sun, 28 Aug 2011 04:00:00 +0100 5282901 Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes http://www.medworm.com/index.php?rid=5282899&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FQqqW4Ea7Pso%2Fncb2320 Authors: Kexi Yi, Jay R. Unruh, Manqi Deng, Brian D. Slaughter, Boris Rubinstein & Rong Li Mature mammalian oocytes are poised for completing meiosis II (MII) on fertilization by positioning the spindle close to an actomyosin-rich cortical cap. Here, we show that the Arp2/3 complex localizes to the cortical cap in a Ran-GTPase-dependent manner and nucleates actin filaments in the cortical cap and a cytoplasmic actin network. Inhibition of Arp2/3 activity leads to rapid dissociation of the spindle from the cortex. Live-cell imaging and spatiotemporal image correlation spectroscopy analysis reveal that actin filaments flow continuously away from the Arp2/3-rich cortex, driving a cytoplasmic streaming expected to exert a net pushing force on the spi... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282899 Sun, 28 Aug 2011 04:00:00 +0100 5282899 DNA-damage response and repair activities at uncapped telomeres depend on RNF8 http://www.medworm.com/index.php?rid=5181231&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FdjcimkTPW7M%2Fncb2326 Authors: Marieke H. Peuscher & Jacqueline J. L. Jacobs Loss of telomere protection causes natural chromosome ends to become recognized by DNA-damage response and repair proteins. These events result in ligation of chromosome ends with dysfunctional telomeres, thereby causing chromosomal aberrations on cell division. The control of these potentially dangerous events at deprotected chromosome ends with their unique telomeric chromatin configuration is poorly understood. In particular, it is unknown to what extent bulky modification of telomeric chromatin is involved. Here we show that uncapped telomeres accumulate ubiquitylated histone H2A in a manner dependent on the E3 ligase RNF8. The ability of RNF8 to ubiquitylate telomeric chromatin is associated with its capacity to facilitate acc... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181231 Sat, 20 Aug 2011 23:00:00 +0100 5181231 aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division http://www.medworm.com/index.php?rid=5181230&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F-r4qs2JpMRA%2Fncb2315 Authors: Matilde Galli, Javier Muñoz, Vincent Portegijs, Mike Boxem, Stephan W. Grill, Albert J. R. Heck & Sander van den Heuvel The position of the mitotic spindle controls the plane of cell cleavage and determines whether polarized cells divide symmetrically or asymmetrically. In animals, an evolutionarily conserved pathway of LIN-5 (homologues: Mud and NuMA), GPR-1/2 (homologues: Pins, LGN, AGS-3) and Gα mediates spindle positioning, and acts downstream of the conserved PAR-3–PAR-6–aPKC polarity complex. However, molecular interactions between polarity proteins and LIN-5–GPR–Gα remain to be identified. Here we describe a quantitative mass spectrometry approach for in vivo identification of protein kinase substrates. Applying this strategy to Ca... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181230 Sat, 20 Aug 2011 23:00:00 +0100 5181230 miRNA-mediated feedback inhibition of JAK/STAT morphogen signalling establishes a cell fate threshold http://www.medworm.com/index.php?rid=5181220&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FpYuloxxUB3c%2Fncb2316 Authors: Wan Hee Yoon, Hans Meinhardt & Denise J. Montell Patterns of cell fates generated by morphogens are critically important for normal development; however, the mechanisms by which graded morphogen signals are converted into all-or-none cell fate responses are incompletely understood. In the Drosophila ovary, high and sustained levels of the secreted morphogen Unpaired (Upd) specify the migratory border-cell population by activating the signal transducer and activator of transcription (STAT). A lower or transient level of STAT activity specifies a non-migratory population of follicle cells. Here we identify miR-279 as a component of a feedback pathway that further dampens the response in cells with low levels of JAK/STAT activity. miR-279 directly repressed STAT, and loss of miR-... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181220 Sat, 20 Aug 2011 23:00:00 +0100 5181220 In vitro generation of human cells with cancer stem cell properties http://www.medworm.com/index.php?rid=5181219&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F1hjsBSyrD70%2Fncb2308 Authors: Paola Scaffidi & Tom Misteli (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181219 Sat, 20 Aug 2011 23:00:00 +0100 5181219 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements http://www.medworm.com/index.php?rid=5181217&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F1q8U9oIkDKg%2Fncb2306 Authors: Constance Richter, Katarzyna Oktaba, Jonas Steinmann, Jürg Müller & Juergen A. Knoblich (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181217 Sat, 20 Aug 2011 23:00:00 +0100 5181217 Notch post-translationally regulates β-catenin protein in stem and progenitor cells http://www.medworm.com/index.php?rid=5282898&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FuS9CLE6ADUo%2Fncb2313 This study reveals a previously unrecognized function of Notch in negatively titrating active β-catenin protein levels in stem and progenitor cells. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5282898 Sun, 14 Aug 2011 04:00:00 +0100 5282898 E2F transcription factor-1 regulates oxidative metabolism http://www.medworm.com/index.php?rid=5181232&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F9QCELzpwRv8%2Fncb2309 Authors: Emilie Blanchet, Jean-Sébastien Annicotte, Sylviane Lagarrigue, Victor Aguilar, Cyrielle Clapé, Carine Chavey, Vanessa Fritz, François Casas, Florence Apparailly, Johan Auwerx & Lluis Fajas Cells respond to stress by coordinating proliferative and metabolic pathways. Starvation restricts cell proliferative (glycolytic) and activates energy productive (oxidative) pathways. Conversely, cell growth and proliferation require increased glycolytic and decreased oxidative metabolism levels. E2F transcription factors regulate both proliferative and metabolic genes. E2Fs have been implicated in the G1/S cell-cycle transition, DNA repair, apoptosis, development and differentiation. In pancreatic β-cells, E2F1 gene regulation facilitated glucose-stimulated insulin sec... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181232 Sat, 13 Aug 2011 23:00:00 +0100 5181232 Actin dynamics counteract membrane tension during clathrin-mediated endocytosis http://www.medworm.com/index.php?rid=5181229&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FD6SeGYQ4QL4%2Fncb2307 Authors: Steeve Boulant, Comert Kural, Jean-Christophe Zeeh, Florent Ubelmann & Tomas Kirchhausen Clathrin-mediated endocytosis is independent of actin dynamics in many circumstances but requires actin polymerization in others. We show that membrane tension determines the actin dependence of clathrin-coat assembly. As found previously, clathrin assembly supports formation of mature coated pits in the absence of actin polymerization on both dorsal and ventral surfaces of non-polarized mammalian cells, and also on basolateral surfaces of polarized cells. Actin engagement is necessary, however, to complete membrane deformation into a coated pit on apical surfaces of polarized cells and, more generally, on the surface of any cell in which the plasma membrane is under tension from osmotic s... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181229 Sat, 13 Aug 2011 23:00:00 +0100 5181229 Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells http://www.medworm.com/index.php?rid=5181221&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FTrjs6wHtPIQ%2Fncb2314 Authors: Derk ten Berge, Dorota Kurek, Tim Blauwkamp, Wouter Koole, Alex Maas, Elif Eroglu, Ronald K. Siu & Roel Nusse Pluripotent stem cells exist in naive and primed states, epitomized by mouse embryonic stem cells (ESCs) and the developmentally more advanced epiblast stem cells (EpiSCs; ref. ). In the naive state of ESCs, the genome has an unusual open conformation and possesses a minimum of repressive epigenetic marks. In contrast, EpiSCs have activated the epigenetic machinery that supports differentiation towards the embryonic cell types. The transition from naive to primed pluripotency therefore represents a pivotal event in cellular differentiation. But the signals that control this fundamental differentiation step remain unclear. We show here that paracrine and autocrine ... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181221 Sat, 13 Aug 2011 23:00:00 +0100 5181221 Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations http://www.medworm.com/index.php?rid=5181228&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fsftc9yV8pbU%2Fncb2301 Authors: Danilo Ritz, Maja Vuk, Philipp Kirchner, Monika Bug, Sabina Schütz, Arnold Hayer, Sebastian Bremer, Caleb Lusk, Robert H. Baloh, Houkeun Lee, Timo Glatter, Matthias Gstaiger, Ruedi Aebersold, Conrad C. Weihl & Hemmo Meyer The AAA-ATPase VCP (also known as p97) cooperates with distinct cofactors to process ubiquitylated proteins in different cellular pathways. VCP missense mutations cause a systemic degenerative disease in humans, but the molecular pathogenesis is unclear. We used an unbiased mass spectrometry approach and identified a VCP complex with the UBXD1 cofactor, which binds to the plasma membrane protein caveolin-1 (CAV1) and whose formation is specifically disrupted by disease-associated mutations. We show that VCP–UBXD1 targets mono-ubiquitylated CAV1 in ... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181228 Sat, 06 Aug 2011 23:00:00 +0100 5181228 RALA and RALBP1 regulate mitochondrial fission at mitosis http://www.medworm.com/index.php?rid=5181227&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fd4ncGbjCUwQ%2Fncb2310 RALA and RALBP1 regulate mitochondrial fission at mitosis Nature Cell Biology 13, 1108 (2011). doi:10.1038/ncb2310 Authors: David F. Kashatus, Kian-Huat Lim, Donita C. Brady, Nicole L. K. Pershing, Adrienne D. Cox & Christopher M. Counter Mitochondria exist as dynamic interconnected networks that are maintained through a balance of fusion and fission. Equal distribution of mitochondria to daughter cells during mitosis requires fission. Mitotic mitochondrial fission depends on both the relocalization of the large GTPase DRP1 to the outer mitochondrial membrane and phosphorylation of Ser 616 on DRP1 by the mitotic kinase cyclin B–CDK1 (ref. ). We now report that these processes are mediated by the small Ras-like GTPase RALA and its effector RALBP1 (also know... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181227 Sat, 06 Aug 2011 23:00:00 +0100 5181227 The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation http://www.medworm.com/index.php?rid=5181224&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FA8ZFuM9Nyqg%2Fncb2304 Authors: Ita Costello, Inga-Marie Pimeisl, Sarah Dräger, Elizabeth K. Bikoff, Elizabeth J. Robertson & Sebastian J. Arnold Instructive programmes guiding cell-fate decisions in the developing mouse embryo are controlled by a few so-termed master regulators. Genetic studies demonstrate that the T-box transcription factor Eomesodermin (Eomes) is essential for epithelial-to-mesenchymal transition, mesoderm migration and specification of definitive endoderm during gastrulation. Here we report that Eomes expression within the primitive streak marks the earliest cardiac mesoderm and promotes formation of cardiovascular progenitors by directly activating the bHLH (basic-helix-loop-helix) transcription factor gene Mesp1 upstream of the core cardiac transcriptional machinery. In marked con... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181224 Sat, 06 Aug 2011 23:00:00 +0100 5181224 MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis http://www.medworm.com/index.php?rid=5181218&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FdnYKIDAKB4E%2Fncb2297 Authors: Catarina P. Samora, Binyam Mogessie, Leslie Conway, Jennifer L. Ross, Anne Straube & Andrew D. McAinsh (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181218 Sat, 06 Aug 2011 23:00:00 +0100 5181218 RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation http://www.medworm.com/index.php?rid=5085839&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F4wobxK8HjWw%2Fncb2319 Nature Cell Biology 13, 1010 (2011). doi:10.1038/ncb2319 Author: Fernando Calvo, Victoria Sanz-Moreno, Lorena Agudo-Ibáñez, Fredrik Wallberg, Erik Sahai, Christopher J. Marshall & Piero Crespo (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085839 Sun, 31 Jul 2011 23:00:00 +0100 5085839 Research highlights http://www.medworm.com/index.php?rid=5085824&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FPrCQmMNV79U%2Fncb2317 Nature Cell Biology 13, 891 (2011). doi:10.1038/ncb2317 (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085824 Sun, 31 Jul 2011 23:00:00 +0100 5085824 FBXW5 controls centrosome number http://www.medworm.com/index.php?rid=5085823&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FYRhmQEnPmpc%2Fncb2312 Authors: Julia Pagan & Michele Pagano Regulatory mechanisms to prevent centriole overduplication during the cell cycle are not completely understood. In this issue, FBXW5 is shown to control the degradation of the centriole assembly factor HsSAS-6. Moreover, the study proposes that FBXW5 is a substrate of both PLK4 and APC/C, two established regulators of centriole duplication. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085823 Sun, 31 Jul 2011 23:00:00 +0100 5085823 esBAF safeguards Stat3 binding to maintain pluripotency http://www.medworm.com/index.php?rid=5085822&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FIVKz1Z9gg3k%2Fncb2311 Authors: Noa Novershtern & Jacob H. Hanna How the unique chromatin configuration of embryonic stem cells (ESCs) integrates inputs from exogenous stimuli to maintain pluripotency remains largely unknown. The ESC-specific ATP-dependent chromatin-remodelling (esBAF) complex maintains the accessibility of the target sites of Stat3, a leukaemia inhibitory factor (LIF) signalling effector, by preventing repressive localized polycomb-mediated trimethylation of Lys 27 of histone 3 (H3K27me3). (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085822 Sun, 31 Jul 2011 23:00:00 +0100 5085822 The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal http://www.medworm.com/index.php?rid=5085820&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FyVsGC5dwljI%2Fncb2303 Authors: Bin Zhao, Karen Tumaneng & Kun-Liang Guan (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085820 Sun, 31 Jul 2011 23:00:00 +0100 5085820 Hunting the elusive oncogene: a stroke of good luck http://www.medworm.com/index.php?rid=5085819&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FwAQl1Jlf5-w%2Fncb2302 Nature Cell Biology 13, 876 (2011). doi:10.1038/ncb2302 Author: Robert A. Weinberg (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085819 Sun, 31 Jul 2011 23:00:00 +0100 5085819 Change the Equation: Improving science and mathematics education in the US http://www.medworm.com/index.php?rid=5085818&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FhYv73X5wGEs%2Fncb2318 Nature Cell Biology 13, 875 (2011). doi:10.1038/ncb2318 Change the Equation, a non-profit group of more than 100 corporate organizations, is committed to improving the state of mathematics and science education in the US. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085818 Sun, 31 Jul 2011 23:00:00 +0100 5085818 Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling http://www.medworm.com/index.php?rid=5181226&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F96SUtP7Vlqs%2Fncb2298 Authors: Guiomar Solanas, Carme Cortina, Marta Sevillano & Eduard Batlle The formation and maintenance of complex organs requires segregation of distinct cell populations into defined territories (that is, cell sorting) and the establishment of boundaries between them. Here we have investigated the mechanism by which Eph/ephrin signalling controls the compartmentalization of cells in epithelial tissues. We show that EphB/ephrin-B signalling in epithelial cells regulates the formation of E-cadherin-based adhesions. EphB receptors interact with E-cadherin and with the metalloproteinase ADAM10 at sites of adhesion and their activation induces shedding of E-cadherin by ADAM10 at interfaces with ephrin-B1-expressing cells. This process results in asymmetric localization of E-cadherin and, a... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181226 Sat, 30 Jul 2011 23:00:00 +0100 5181226 FOXO1 is an essential regulator of pluripotency in human embryonic stem cells http://www.medworm.com/index.php?rid=5181225&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FnmSQNtcgY2E%2Fncb2293 Authors: Xin Zhang, Safak Yalcin, Dung-Fang Lee, Tsung-Yin J. Yeh, Seung-Min Lee, Jie Su, Sathish Kumar Mungamuri, Pauline Rimmelé, Marion Kennedy, Rani Sellers, Markus Landthaler, Thomas Tuschl, Nai-Wen Chi, Ihor Lemischka, Gordon Keller & Saghi Ghaffari Pluripotency of embryonic stem cells (ESCs) is defined by their ability to differentiate into three germ layers and derivative cell types and is established by an interactive network of proteins including OCT4 (also known as POU5F1; ref. ), NANOG (refs , ), SOX2 (ref. ) and their binding partners. The forkhead box O (FoxO) transcription factors are evolutionarily conserved regulators of longevity and stress response whose function is inhibited by AKT protein kinase. FoxO proteins are required for the maintenance of... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181225 Sat, 30 Jul 2011 23:00:00 +0100 5181225 Phagocytic activity of neuronal progenitors regulates adult neurogenesis http://www.medworm.com/index.php?rid=5181223&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F7ESQnI0Oyyg%2Fncb2299 Authors: Zhenjie Lu, Michael R. Elliott, Yubo Chen, James T. Walsh, Alexander L. Klibanov, Kodi S. Ravichandran & Jonathan Kipnis Whereas thousands of new neurons are generated daily during adult life, only a fraction of them survive and become part of neural circuits; the rest die, and their corpses are presumably cleared by resident phagocytes. How the dying neurons are removed and how such clearance influences neurogenesis are not well understood. Here, we identify an unexpected phagocytic role for the doublecortin (DCX)-positive neuronal progenitor cells during adult neurogenesis. Our in vivo andex vivo studies demonstrate that DCX+ cells comprise a significant phagocytic population within the neurogenic zones. Intracellular engulfment protein ELMO1, which promotes Rac activation d... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5181223 Sat, 30 Jul 2011 23:00:00 +0100 5181223 Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons http://www.medworm.com/index.php?rid=5085836&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Fgiepdo5A_xo%2Fncb2292 We examined the role of lamellipodin (Lpd), a homologue of a key regulator of neuronal migration and polarization in Caenorhabditis elegans, in corticogenesis. Lpd depletion caused bipolar pyramidal neurons to adopt a tangential, rather than radial-glial, migration mode without affecting cell fate. Mechanistically, Lpd depletion reduced the activity of SRF, a transcription factor regulated by changes in the ratio of polymerized to unpolymerized actin. Therefore, Lpd depletion exposes a role for SRF in directing pyramidal neurons to select a radial migration pathway along glia rather than a tangential migration mode. (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085836 Sat, 23 Jul 2011 23:00:00 +0100 5085836 Cytoskeletal polarity mediates localized induction of the heart progenitor lineage http://www.medworm.com/index.php?rid=5085831&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FiHNxKpXKM6w%2Fncb2291 Authors: James Cooley, Stacia Whitaker, Sarah Sweeney, Scott Fraser & Brad Davidson Cells must make appropriate fate decisions within a complex and dynamic environment. In vitro studies indicate that the cytoskeleton acts as an integrative platform for this environmental input. External signals regulate cytoskeletal dynamics and the cytoskeleton reciprocally modulates signal transduction. However, in vivo studies linking cytoskeleton/signalling interactions to embryonic cell fate specification remain limited. Here we show that the cytoskeleton modulates heart progenitor cell fate. Our studies focus on differential induction of heart fate in the basal chordate Ciona intestinalis. We have found that differential induction does not simply reflect differential exposure to the inductive sig... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085831 Sat, 23 Jul 2011 23:00:00 +0100 5085831 N-WASP regulates the epithelial junctional actin cytoskeleton through a non-canonical post-nucleation pathway http://www.medworm.com/index.php?rid=5085829&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F3OwsO4d5WpA%2Fncb2290 Authors: Eva M. Kovacs, Suzie Verma, Radiya G. Ali, Aparna Ratheesh, Nicholas A. Hamilton, Anna Akhmanova & Alpha S. Yap (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085829 Sat, 23 Jul 2011 23:00:00 +0100 5085829 esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function http://www.medworm.com/index.php?rid=5085826&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FIx1eBsSjFA0%2Fncb2285 Authors: Lena Ho, Erik L. Miller, Jehnna L. Ronan, Wen Qi Ho, Raja Jothi & Gerald R. Crabtree (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085826 Sat, 23 Jul 2011 23:00:00 +0100 5085826 A role for CSLD3 during cell-wall synthesis in apical plasma membranes of tip-growing root-hair cells http://www.medworm.com/index.php?rid=5085834&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F2OyLEZ7aIBw%2Fncb2294 Authors: Sungjin Park, Amy L. Szumlanski, Fangwei Gu, Feng Guo & Erik Nielsen In plants, cell shape is defined by the cell wall, and changes in cell shape and size are dictated by modification of existing cell walls and deposition of newly synthesized cell-wall material. In root hairs, expansion occurs by a process called tip growth, which is shared by root hairs, pollen tubes and fungal hyphae. We show that cellulose-like polysaccharides are present in root-hair tips, and de novo synthesis of these polysaccharides is required for tip growth. We also find that eYFP–CSLD3 proteins, but not CESA cellulose synthases, localize to a polarized plasma-membrane domain in root hairs. Using biochemical methods and genetic complementation of a csld3 mutant with a chimaeric CSLD3 protein con... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085834 Sat, 16 Jul 2011 23:00:00 +0100 5085834 Cleavage of cohesin rings coordinates the separation of centrioles and chromatids http://www.medworm.com/index.php?rid=5085833&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FW_QX__CiSPQ%2Fncb2280 Authors: Laura Schöckel, Martin Möckel, Bernd Mayer, Dominik Boos & Olaf Stemmann Cohesin pairs sister chromatids by forming a tripartite Scc1–Smc1–Smc3 ring around them. In mitosis, cohesin is removed from chromosome arms by the phosphorylation- dependent prophase pathway. Centromeric cohesin is protected by shugoshin 1 and protein phosphatase 2A (Sgo1–PP2A) and opened only in anaphase by separase-dependent cleavage of Scc1 (refs , , ). Following chromosome segregation, centrioles loosen their tight orthogonal arrangement, which licenses later centrosome duplication in S phase. Although a role of separase in centriole disengagement has been reported, the molecular details of this process remain enigmatic. Here, we identify cohe... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085833 Sat, 09 Jul 2011 23:00:00 +0100 5085833 Mir193b–365 is essential for brown fat differentiation http://www.medworm.com/index.php?rid=5085832&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2F9mypZ7Z7Yfk%2Fncb2286 Mir193b–365 is essential for brown fat differentiation Nature Cell Biology 13, 958 (2011). doi:10.1038/ncb2286 Authors: Lei Sun, Huangming Xie, Marcelo A. Mori, Ryan Alexander, Bingbing Yuan, Shilpa M. Hattangadi, Qingqing Liu, C. Ronald Kahn & Harvey F. Lodish Mammals have two principal types of fat. White adipose tissue primarily serves to store extra energy as triglycerides, whereas brown adipose tissue is specialized to burn lipids for heat generation and energy expenditure as a defence against cold and obesity. Recent studies have demonstrated that brown adipocytes arise in vivo from a Myf5-positive, myoblastic progenitor by the action of Prdm16 (PR domain containing 16). Here, we identified a brown-fat-enriched miRNA cluster, MiR-193b–365, as a key regulator ... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085832 Sat, 09 Jul 2011 23:00:00 +0100 5085832 Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability http://www.medworm.com/index.php?rid=5085828&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2Ftf-f_72jn6k%2Fncb2287 Authors: Yan-Fei Gao, Teng Li, Yan Chang, Yu-Bo Wang, Wei-Na Zhang, Wei-Hua Li, Kun He, Rui Mu, Cheng Zhen, Jiang-Hong Man, Xin Pan, Tao Li, Liang Chen, Ming Yu, Bing Liang, Yuan Chen, Qing Xia, Tao Zhou, Wei-Li Gong, Ai-Ling Li, Hui-Yan Li & Xue-Min Zhang (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085828 Sat, 09 Jul 2011 23:00:00 +0100 5085828 Mitotic internalization of planar cell polarity proteins preserves tissue polarity http://www.medworm.com/index.php?rid=5085825&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FjPIaFqh-5gY%2Fncb2284 Authors: Danelle Devenport, Daniel Oristian, Evan Heller & Elaine Fuchs (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085825 Sat, 09 Jul 2011 23:00:00 +0100 5085825 The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication http://www.medworm.com/index.php?rid=5085838&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FTBc7j-z0pCI%2Fncb2282 The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication Nature Cell Biology 13, 1004 (2011). doi:10.1038/ncb2282 Authors: Anja Puklowski, Yahya Homsi, Debora Keller, Martin May, Sangeeta Chauhan, Uta Kossatz, Viktor Grünwald, Stefan Kubicka, Andreas Pich, Michael P. Manns, Ingrid Hoffmann, Pierre Gönczy & Nisar P. Malek Deregulated centrosome duplication can result in genetic instability and contribute to tumorigenesis. Here, we show that centrosome duplication is regulated by the activity of an E3-ubiquitin ligase that employs the F-box protein FBXW5 (ref. ) as its targeting subunit. Depletion of endogenous FBXW5 or overexpression of an F-box-deleted mutant version results in centrosome overduplication ... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085838 Sat, 02 Jul 2011 23:00:00 +0100 5085838 COPI acts in both vesicular and tubular transport http://www.medworm.com/index.php?rid=5085837&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FU15Hb3MgeI0%2Fncb2273 Authors: Jia-Shu Yang, Carmen Valente, Roman S. Polishchuk, Gabriele Turacchio, Emilie Layre, D. Branch Moody, Christina C. Leslie, Michael H. Gelb, William J. Brown, Daniela Corda, Alberto Luini & Victor W. Hsu Intracellular transport occurs through two general types of carrier, either vesicles or tubules. Coat proteins act as the core machinery that initiates vesicle formation, but the counterpart that initiates tubule formation has been unclear. Here, we find that the coat protein I (COPI) complex initially drives the formation of Golgi buds. Subsequently, a set of opposing lipid enzymatic activities determines whether these buds become vesicles or tubules. Lysophosphatidic acid acyltransferase-γ (LPAATγ) promotes COPI vesicle fission for retrograde vesicular transport. In... Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085837 Sat, 02 Jul 2011 23:00:00 +0100 5085837 A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion http://www.medworm.com/index.php?rid=5085827&cid=s_32087_171_f&fid=32087&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fncb%2Frss%2Fcurrent%2F%7E3%2FSYTXqN42YaU%2Fncb2281 Authors: Martin Harterink, Fillip Port, Magdalena J. Lorenowicz, Ian J. McGough, Marie Silhankova, Marco C. Betist, Jan R. T. van Weering, Roy G. H. P. van Heesbeen, Teije C. Middelkoop, Konrad Basler, Peter J. Cullen & Hendrik C. Korswagen (Source: Nature Cell Biology) Nature Cell Biology journals http://www.medworm.com/rss/comments.php?id=5085827 Sat, 02 Jul 2011 23:00:00 +0100 5085827