MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nature Chemical Biology' source. Sun, 21 Mar 2010 17:01:06 +0100 http://www.medworm.com/index.php?rid=3382135&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FAZ0guZHLuP8%2Fnchembio0410-306e Nature Chemical Biology 6, 306 (2010). doi:10.1038/nchembio0410-306e Author: Tilman Schneider-Poetsch, Takeo Usui, Daisuke Kaida & Minoru Yoshida (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382135 Fri, 19 Mar 2010 17:19:34 +0100 3382135 http://www.medworm.com/index.php?rid=3382134&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FYSoEquj19nE%2Fnchembio0410-306d Nature Chemical Biology 6, 306 (2010). doi:10.1038/nchembio0410-306d (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382134 Fri, 19 Mar 2010 17:19:34 +0100 3382134 http://www.medworm.com/index.php?rid=3382133&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FERLhWG77a5M%2Fnchembio0410-306c Nature Chemical Biology 6, 306 (2010). doi:10.1038/nchembio0410-306c Author: Damian W Young (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382133 Fri, 19 Mar 2010 17:19:34 +0100 3382133 http://www.medworm.com/index.php?rid=3382132&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FlxTuYMB2yew%2Fnchembio0410-306b Nature Chemical Biology 6, 306 (2010). doi:10.1038/nchembio0410-306b Author: Paul Workman & Rob L M van Montfort (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382132 Fri, 19 Mar 2010 17:19:34 +0100 3382132 http://www.medworm.com/index.php?rid=3382131&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F_AYZOYBa03Q%2Fnchembio0410-306a The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors Nature Chemical Biology 6, 306 (2010). doi:10.1038/nchembio0410-306a Author: Alex Berndt, Simon Miller, Olusegun Williams, Daniel D Le, Benjamin T Houseman, Joseph I Pacold, Fabrice Gorrec, Wai-Ching Hon, Pingda Ren, Yi Liu, Christian Rommel, Pascale Gaillard, Thomas Rückle, Matthias K Schwarz, Kevan M Shokat, Jeffrey P Shaw & Roger L Williams (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382131 Fri, 19 Mar 2010 17:19:34 +0100 3382131 http://www.medworm.com/index.php?rid=3382119&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FDCKrfips1ds%2Fnchembio.339 Authors: Lindsey J Macpherson & Ardem Patapoutian Evolutionary conservation of TRPA1 underlies sensation of reactive noxious chemicals from flies to humans. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382119 Fri, 19 Mar 2010 17:19:34 +0100 3382119 http://www.medworm.com/index.php?rid=3382118&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FT7zNOgnp8GM%2Fnchembio.334 Authors: Eric J Dimise & Steven D Bruner The final steps in the biosynthetic pathway to the morphine alkaloids have been revealed with the characterization of two key enzymes. In addition to the widely exploited parent compound, these new O-demethylases control metabolic flux to pharmaceutically useful opioid precursors. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382118 Fri, 19 Mar 2010 17:19:34 +0100 3382118 http://www.medworm.com/index.php?rid=3382117&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FR-a8r7lR3ZQ%2Fnchembio.336 Nature Chemical Biology 6, 249 (2010). doi:10.1038/nchembio.336 Author: Henrik Daub Many kinase inhibitors for cancer therapy are rather nonselective, and their cellular mechanisms of action are incompletely understood. A nested chemical proteomics and chemical genetics strategy reveals which cellular targets of the clinical kinase inhibitor dasatinib functionally relate to its anti-oncogenic activity. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382117 Fri, 19 Mar 2010 17:19:34 +0100 3382117 http://www.medworm.com/index.php?rid=3382116&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FqjjnpigGyF0%2Fnchembio.335 Nature Chemical Biology 6, 248 (2010). doi:10.1038/nchembio.335 Author: Tamara L Hendrickson In most archaea, the enzyme TiaS post-transcriptionally modifies a cytidine in the anticodon of tRNAIle, converting it to agmatidine (agm2C or C+). This unique nucleoside allows translation at the AUA isoleucine codon and prevents misreading of the AUG methionine codon. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382116 Fri, 19 Mar 2010 17:19:34 +0100 3382116 http://www.medworm.com/index.php?rid=3382115&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FA63XXOlinpY%2Fnchembio.344 Nature Chemical Biology 6, 246 (2010). doi:10.1038/nchembio.344 (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382115 Fri, 19 Mar 2010 17:19:34 +0100 3382115 http://www.medworm.com/index.php?rid=3382114&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FdkeCK-j0-6E%2Fnchembio.346 Nature Chemical Biology 6, 245 (2010). doi:10.1038/nchembio.346 Scientific referees accept a critical role in the peer review process. What do we expect of Nature Chemical Biology reviewers? (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382114 Fri, 19 Mar 2010 17:19:34 +0100 3382114 http://www.medworm.com/index.php?rid=3382130&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F9sTX5kjo85A%2Fnchembio.322 Authors: Yusuke Oguchi, Sergey V Mikhailenko, Takashi Ohki, Adrian O Olivares, Enrique M De La Cruz & Shin'ichi Ishiwata (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382130 Sun, 14 Mar 2010 00:00:00 +0100 3382130 http://www.medworm.com/index.php?rid=3382126&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FnlaaAeV9J_k%2Fnchembio.317 Authors: Jillian M Hagel & Peter J Facchini Two previously undetected enzymes involved in morphine biosynthesis and unique among plants to opium poppy have been identified as non-heme dioxygenases, in contrast to the functionally analogous cytochrome P450s found in mammals. We used functional genomics to isolate thebaine 6-O-demethylase (T6ODM) and codeine O-demethylase (CODM), the only known 2-oxoglutarate/Fe(II)-dependent dioxygenases that catalyze O-demethylation. Virus-induced gene silencing of T6ODM and CODM in opium poppy efficiently blocked metabolism at thebaine and codeine, respectively. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382126 Sun, 14 Mar 2010 00:00:00 +0100 3382126 http://www.medworm.com/index.php?rid=3382121&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FcYgrgJM89Wc%2Fnchembio.333 We report a strategy for the transformation of these hits into much more potent inhibitors without compound optimization. Appending a derivative of Ru(II)(tris-bipyridyl)2+, an efficient photosensitizer of singlet oxygen production, to synthetic protein-binding compounds results in highly potent and specific target protein inactivation upon irradiation with visible light. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382121 Sun, 14 Mar 2010 00:00:00 +0100 3382121 http://www.medworm.com/index.php?rid=3382125&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FJA8wNXzYR4k%2Fnchembio.316 We report a chemical approach for monoubiquitylation and SUMOylation of PCNA through disulfide exchange and intein chemistry. We used the chemically ubiquitylated and SUMOylated PCNAs in studying translesion DNA synthesis and revealed a surprising degree of flexibility of the ubiquitin modification. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382125 Sun, 07 Mar 2010 00:00:00 +0100 3382125 http://www.medworm.com/index.php?rid=3382124&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FOUeBzlEQw_8%2Fnchembio.315 Authors: Champak Chatterjee, Robert K McGinty, Beat Fierz & Tom W Muir We have developed a readily accessible disulfide-directed methodology for the site-specific modification of histones by ubiquitin and ubiquitin-like proteins. The disulfide-linked analog of mono-ubiquitylated H2B stimulated the H3K79 methyltransferase activity of hDot1L to a similar extent as the native isopeptide linkage. This permitted structure-activity studies of ubiquitylated mononucleosomes that revealed plasticity in the mechanism of hDot1L stimulation and identified surfaces of ubiquitin important for activation. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382124 Sun, 07 Mar 2010 00:00:00 +0100 3382124 http://www.medworm.com/index.php?rid=3382129&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FG5GPh2_9DFM%2Fnchembio.332 Authors: Jiannong Li, Uwe Rix, Bin Fang, Yun Bai, Arthur Edwards, Jacques Colinge, Keiryn L Bennett, Jingchun Gao, Lanxi Song, Steven Eschrich, Giulio Superti-Furga, John Koomen & Eric B Haura (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382129 Sun, 28 Feb 2010 00:00:00 +0100 3382129 http://www.medworm.com/index.php?rid=3382128&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FB_u1tPgHIJM%2Fnchembio.319 Authors: Adam L Garske, Samuel S Oliver, Elise K Wagner, Catherine A Musselman, Gary LeRoy, Benjamin A Garcia, Tatiana G Kutateladze & John M Denu (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382128 Sun, 28 Feb 2010 00:00:00 +0100 3382128 http://www.medworm.com/index.php?rid=3382123&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FJLnrCIkTsOk%2Fnchembio.314 We describe a new method for producing homogeneous eukaryotic N-glycoproteins. The method involves the engineering and functional transfer of the Campylobacter jejuni glycosylation machinery in Escherichia coli to express glycosylated proteins with the key GlcNAc-Asn linkage. The bacterial glycans were then trimmed and remodeled in vitro by enzymatic transglycosylation to fulfill a eukaryotic N-glycosylation. It provides a potentially general platform for producing eukaryotic N-glycoproteins. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382123 Sun, 28 Feb 2010 00:00:00 +0100 3382123 http://www.medworm.com/index.php?rid=3382122&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F69atjsVd4l4%2Fnchembio.331 Authors: Johannes Kroiss, Martin Kaltenpoth, Bernd Schneider, Maria-Gabriele Schwinger, Christian Hertweck, Ravi Kumar Maddula, Erhard Strohm & Aleš Svatoš Beewolf digger wasps cultivate specific symbiotic bacteria (Streptomyces spp.) that are incorporated into the larval cocoon for protection against pathogens. We identified the molecular basis of this protective symbiosis in the natural context and demonstrate that the bacteria produce a 'cocktail' of nine antibiotic substances. The complementary action of all symbiont-produced antibiotics confers a potent antimicrobial defense for the wasp larvae that parallels the 'combination prophylaxis' known from human medicine. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382122 Sun, 28 Feb 2010 00:00:00 +0100 3382122 http://www.medworm.com/index.php?rid=3382120&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fbj8tuwu7wOs%2Fnchembio.321 Authors: Masanori Matsuzaki, Tatsuya Hayama, Haruo Kasai & Graham C R Ellis-Davies We have synthesized a photosensitive (or caged) 4-carboxymethoxy-5,7-dinitroindolinyl (CDNI) derivative of γ-aminobutyric acid (GABA). Two-photon excitation of CDNI-GABA produced rapid activation of GABAergic currents in neurons in brain slices with an axial resolution of approximately 2 μm and enabled high-resolution functional mapping of GABA-A receptors. Two-photon uncaging of GABA, the main inhibitory neurotransmitter, should allow detailed studies of receptor function and synaptic integration with subcellular precision. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382120 Sun, 21 Feb 2010 00:00:00 +0100 3382120 http://www.medworm.com/index.php?rid=3269378&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FIL_B8jWamZc%2Fnchembio0310-244c Nature Chemical Biology 6, 244 (2010). doi:10.1038/nchembio0310-244c Author: Michael B Feldman, Daniel S Terry, Roger B Altman & Scott C Blanchard (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269378 Sat, 13 Feb 2010 16:01:23 +0100 3269378 http://www.medworm.com/index.php?rid=3269377&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Flu8YmZPv9yg%2Fnchembio0310-244b The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors Nature Chemical Biology 6, 244 (2010). doi:10.1038/nchembio0310-244b Author: Alex Berndt, Simon Miller, Olusegun Williams, Daniel D Le, Benjamin T Houseman, Joseph I Pacold, Fabrice Gorrec, Wai-Ching Hon, Yi Liu, Christian Rommel, Pascale Gaillard, Thomas Rückle, Matthias K Schwarz, Kevan M Shokat, Jeffrey P Shaw & Roger L Williams (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269377 Sat, 13 Feb 2010 16:01:23 +0100 3269377 http://www.medworm.com/index.php?rid=3269376&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FNn4q6OX1f6M%2Fnchembio0310-244a Nature Chemical Biology 6, 244 (2010). doi:10.1038/nchembio0310-244a Author: Adam C Palmer, Elaine Angelino & Roy Kishony (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269376 Sat, 13 Feb 2010 16:01:23 +0100 3269376 http://www.medworm.com/index.php?rid=3269365&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F6mE-KpJubSg%2Fnchembio.324 Authors: Timothy E McGraw & Vivek Mittal A reverse genetic engineering approach identifies metabolic enzymes and their cellular pathways as potential regulators of myoblast differentiation. Targeting these metabolic nodes has provocative implications for drug discovery and therapeutic efficacy. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269365 Sat, 13 Feb 2010 16:01:23 +0100 3269365 http://www.medworm.com/index.php?rid=3269364&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F5W9wqYgrcu8%2Fnchembio.325 Nature Chemical Biology 6, 174 (2010). doi:10.1038/nchembio.325 Author: Damian W Young Organic synthesis plays a leading role in the discovery of small molecules for the exploration of biological systems. Therefore, the development of efficient strategies for the preparation of these molecules is a necessary aspect of the small-molecule approach to chemical biology. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269364 Sat, 13 Feb 2010 16:01:23 +0100 3269364 http://www.medworm.com/index.php?rid=3269363&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FsUnDNOYljmY%2Fnchembio.320 Authors: Jeremy L Jenkins & Laszlo Urban A high-throughput phenotypic screen in zebrafish embryos provides distinctive signatures by which neuroactive chemicals can be classified. These “behavioral barcodes” provide a systems approach to elucidating the mechanistic neuropharmacology of drugs and novel compounds. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269363 Sat, 13 Feb 2010 16:01:23 +0100 3269363 http://www.medworm.com/index.php?rid=3269362&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FGIUqUBemp0U%2Fnchembio.328 Nature Chemical Biology 6, 170 (2010). doi:10.1038/nchembio.328 (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269362 Sat, 13 Feb 2010 16:01:23 +0100 3269362 http://www.medworm.com/index.php?rid=3269361&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F_k59SKaAhG4%2Fnchembio.297 Authors: Oleg Fedorov, Susanne Müller & Stefan Knapp The complexity of cancer signaling and the resulting difficulties in target selection have strongly biased kinase drug discovery towards clinically validated targets. Recently, novel kinase targets that are uncharacterized have emerged from genome sequencing and RNAi studies. Chemical probes are urgently needed to functionally annotate these kinases and to stimulate new drug discovery efforts. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269361 Sat, 13 Feb 2010 16:01:23 +0100 3269361 http://www.medworm.com/index.php?rid=3269360&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F6PQn8P1C9ic%2Fnchembio.303 This article discusses the strengths and weaknesses of the most popular screening approaches and the utility of compounds derived from them. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269360 Sat, 13 Feb 2010 16:01:23 +0100 3269360 http://www.medworm.com/index.php?rid=3269359&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fh0wZ31DsV_E%2Fnchembio.296 Nature Chemical Biology 6, 159 (2010). doi:10.1038/nchembio.296 Author: Stephen V Frye Chemical biologists frequently aim to create small-molecule probes that interact with a specific protein in vitro in order to explore the role of the protein in a broader biological context (cells or organisms), but a common understanding of what makes a high-quality probe is lacking. Here I propose a set of principles to guide probe qualification. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269359 Sat, 13 Feb 2010 16:01:23 +0100 3269359 http://www.medworm.com/index.php?rid=3269358&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FeMoHz8nJdj0%2Fnchembio.330 Nature Chemical Biology 6, 157 (2010). doi:10.1038/nchembio.330 Increased transparency and consistency in reporting well-validated chemical probes will further enhance the impact of this exciting and rapidly advancing area of chemical biology. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269358 Sat, 13 Feb 2010 16:01:23 +0100 3269358 http://www.medworm.com/index.php?rid=3269367&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FhpLHoyIDeSs%2Fnchembio.326 Authors: Tilman Schneider-Poetsch, Takeo Usui, Daisuke Kaida & Minoru Yoshida (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269367 Fri, 12 Feb 2010 00:00:00 +0100 3269367 http://www.medworm.com/index.php?rid=3269366&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FwbnHLcFQDpo%2Fnchembio.318 Authors: Julie A Zorn & James A Wells (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269366 Fri, 12 Feb 2010 00:00:00 +0100 3269366 http://www.medworm.com/index.php?rid=3382127&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FLMsSjSCPWW0%2Fnchembio.323 Authors: Yoshiho Ikeuchi, Satoshi Kimura, Tomoyuki Numata, Daigo Nakamura, Takashi Yokogawa, Toshihiko Ogata, Takeshi Wada, Takeo Suzuki & Tsutomu Suzuki (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3382127 Sun, 07 Feb 2010 00:00:00 +0100 3382127 http://www.medworm.com/index.php?rid=3269375&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FVlZUYBbEieg%2Fnchembio.313 Authors: James E Bradner, Nathan West, Melissa L Grachan, Edward F Greenberg, Stephen J Haggarty, Tandy Warnow & Ralph Mazitschek (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269375 Sun, 07 Feb 2010 00:00:00 +0100 3269375 http://www.medworm.com/index.php?rid=3269372&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FDTMLCr8K0t4%2Fnchembio.312 Authors: Michael Roitzsch, Olga Fedorova & Anna Marie Pyle (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269372 Sun, 31 Jan 2010 00:00:00 +0100 3269372 http://www.medworm.com/index.php?rid=3269371&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FfqjXhRSD4fo%2Fnchembio.304 Authors: Tilman Schneider-Poetsch, Jianhua Ju, Daniel E Eyler, Yongjun Dang, Shridhar Bhat, William C Merrick, Rachel Green, Ben Shen & Jun O Liu (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269371 Sun, 31 Jan 2010 00:00:00 +0100 3269371 http://www.medworm.com/index.php?rid=3269370&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fvgp_hwd2H3E%2Fnchembio.311 Authors: Stephen B Milne, Keri A Tallman, Remigiusz Serwa, Carol A Rouzer, Michelle D Armstrong, Lawrence J Marnett, Charles M Lukehart, Ned A Porter & H Alex Brown Alkyne-modified phospholipids can be unambiguously identified and differentiated from native species in complex mixtures by formation of dicobalthexacarbonyl complexes. This reaction is specific for alkynes and is unaffected by other glycerophospholipid-related moieties. Enrichment of cells with alkyne-derivatized fatty acids or glycerophospholipids followed by solid-phase sequestration and release is a promising new method for unequivocally monitoring individual glycerophospholipids following incorporation into cells. This technique also facilitates lipidomic analysis of substrates and products. (Source: Nature Chemical Bi... Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269370 Sun, 24 Jan 2010 00:00:00 +0100 3269370 http://www.medworm.com/index.php?rid=3269368&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FHHcFb9S64bk%2Fnchembio.302 Authors: Markus Leibeling, Dennis C Koester, Martin Pawliczek, Svenia C Schild & Daniel B Werz Herein we describe the synthesis of highly substituted chromans and isochromans using carbohydrates as starting materials. Our approach makes use of a Pd-catalyzed domino reaction consisting of oxidative addition, followed by two carbopalladation steps and completed by a cyclization to annelate the benzene moiety. The versatility of this route has been demonstrated by a small library of highly substituted chromans and isochromans. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269368 Sun, 24 Jan 2010 00:00:00 +0100 3269368 http://www.medworm.com/index.php?rid=3184877&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FrqIjYqe62tc%2Fnchembio.300 Nature Chemical Biology 6, 87 (2010). doi:10.1038/nchembio.300 Author: Daniel H Appella A process in which peptide nucleic acids may be used for in vitro evolution has been developed. This method can offer enormous opportunities to evolve stable, non-natural molecules for therapeutic applications. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184877 Tue, 19 Jan 2010 16:15:59 +0100 3184877 http://www.medworm.com/index.php?rid=3184876&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F8bE6qoh0-eE%2Fnchembio.299 Nature Chemical Biology 6, 85 (2010). doi:10.1038/nchembio.299 Author: Gerard D Wright Antibiotics can break down through the action of enzymes or through non-enzymatic processes. In the case of tetracycline, this drug 'debris' can have unexpected biological activities, including selection against resistance. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184876 Tue, 19 Jan 2010 16:15:59 +0100 3184876 http://www.medworm.com/index.php?rid=3184875&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FiUZByYntRMo%2Fnchembio.295 Nature Chemical Biology 6, 84 (2010). doi:10.1038/nchembio.295 Author: Ronald E Ellis Reprogramming cell fates might cure or ameliorate many diseases. New results show that chemical reprogramming can be used in living animals to restore missing cell types. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184875 Tue, 19 Jan 2010 16:15:59 +0100 3184875 http://www.medworm.com/index.php?rid=3184874&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FcXexE4tDTxw%2Fnchembio.305 Authors: Paul Workman & Rob L M van Montfort Phosphoinositide 3-OH kinases (PI(3)Ks) are important lipid signaling enzymes and exciting drug targets for a number of human diseases. The first, much anticipated crystal structure of the delta isoform of PI(3)K provides surprising new insights into the selectivity of inhibitors for this versus other PI(3)K isoforms and facilitates the design of improved drugs. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184874 Tue, 19 Jan 2010 16:15:59 +0100 3184874 http://www.medworm.com/index.php?rid=3184873&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FEX2Aa8j--Gg%2Fnchembio.308 Nature Chemical Biology 6, 80 (2010). doi:10.1038/nchembio.308 (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184873 Tue, 19 Jan 2010 16:15:59 +0100 3184873 http://www.medworm.com/index.php?rid=3184872&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FHteRbA-5v74%2Fnchembio.310 Nature Chemical Biology 6, 79 (2010). doi:10.1038/nchembio.310 Scientists need to devote more attention to the citation lists of scientific papers—the connectivity and usefulness of the scientific literature depend upon it. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184872 Tue, 19 Jan 2010 16:15:59 +0100 3184872 http://www.medworm.com/index.php?rid=3269374&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FXt5CuAAMAEs%2Fnchembio.307 Authors: David Kokel, Jennifer Bryan, Christian Laggner, Rick White, Chung Yan J Cheung, Rita Mateus, David Healey, Sonia Kim, Andreas A Werdich, Stephen J Haggarty, Calum A MacRae, Brian Shoichet & Randall T Peterson (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269374 Sun, 17 Jan 2010 00:00:00 +0100 3269374 http://www.medworm.com/index.php?rid=3269373&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FQ4sBSxohCig%2Fnchembio.306 Authors: Yumiko Ohhashi, Kazuki Ito, Brandon H Toyama, Jonathan S Weissman & Motomasa Tanaka (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269373 Sun, 17 Jan 2010 00:00:00 +0100 3269373 http://www.medworm.com/index.php?rid=3269369&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F-gy0qcnx5hE%2Fnchembio.301 Authors: Abigail L Bracha, Arvind Ramanathan, Sui Huang, Donald E Ingber & Stuart L Schreiber The role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we discovered that the knockdown of three metabolic enzymes—phosphoglycerate kinase (Pgk1), hexose-6-phosphate dehydrogenase (H6pd) and ATP citrate lyase (Acl)—induces differentiation of mouse C2C12 myoblasts even in the presence of mitogens. These enzymes and the pathways they regulate provide new targets for the control of myogenic differentiation in myoblasts and rhabdomyosarcoma cells. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3269369 Sun, 17 Jan 2010 00:00:00 +0100 3269369 http://www.medworm.com/index.php?rid=3184878&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FjXTK2lvaZns%2Fnchembio.298 Authors: James J Fleming & Pamela M England (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184878 Fri, 15 Jan 2010 00:00:00 +0100 3184878 http://www.medworm.com/index.php?rid=3184886&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fl9TLonxA0cw%2Fnchembio.283 Authors: Silvia Campioni, Benedetta Mannini, Mariagioia Zampagni, Anna Pensalfini, Claudia Parrini, Elisa Evangelisti, Annalisa Relini, Massimo Stefani, Christopher M Dobson, Cristina Cecchi & Fabrizio Chiti (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184886 Sun, 10 Jan 2010 00:00:00 +0100 3184886 http://www.medworm.com/index.php?rid=3184883&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FXRbt1NO4N1c%2Fnchembio.293 The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors Nature Chemical Biology 6, 117 (2010). doi:10.1038/nchembio.293 Authors: Alex Berndt, Simon Miller, Olusegun Williams, Daniel D Le, Benjamin T Houseman, Joseph I Pacold, Fabrice Gorrec, Wai-Ching Hon, Yi Liu, Christian Rommel, Pascale Gaillard, Thomas Rückle, Matthias K Schwarz, Kevan M Shokat, Jeffrey P Shaw & Roger L Williams (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184883 Sun, 10 Jan 2010 00:00:00 +0100 3184883 http://www.medworm.com/index.php?rid=3184881&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Frd1kQUsL5Y8%2Fnchembio.289 Authors: Adam C Palmer, Elaine Angelino & Roy Kishony Antibiotics are often unstable and can decay into various compounds with potential biological activities. We found that as tetracycline degrades, the competitive advantage conferred to bacteria by resistance not only diminishes but actually reverses to become a prolonged disadvantage due to the activities of more stable degradation products. Tetracycline decay can lead to net selection against resistance, which may help explain the puzzling coexistence of sensitive and resistant strains in natural environments. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184881 Sun, 10 Jan 2010 00:00:00 +0100 3184881 http://www.medworm.com/index.php?rid=3184887&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fcsx6K30kdjk%2Fnchembio.280 Authors: Yevgeny Brudno, Michael E Birnbaum, Ralph E Kleiner & David R Liu (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184887 Sun, 27 Dec 2009 00:00:00 +0100 3184887 http://www.medworm.com/index.php?rid=3184884&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FmUqWtT96X0M%2Fnchembio.278 Authors: Yanping Zhu, Michael D L Suits, Andrew J Thompson, Sambhaji Chavan, Zoran Dinev, Claire Dumon, Nicola Smith, Kelley W Moremen, Yong Xiang, Aloysius Siriwardena, Spencer J Williams, Harry J Gilbert & Gideon J Davies (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184884 Sun, 27 Dec 2009 00:00:00 +0100 3184884 http://www.medworm.com/index.php?rid=3184882&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F7ilMz1LnqZU%2Fnchembio.284 Authors: Yongfang Zhao, Matthias Quick, Lei Shi, Ernest L Mehler, Harel Weinstein & Jonathan A Javitch (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184882 Sun, 27 Dec 2009 00:00:00 +0100 3184882 http://www.medworm.com/index.php?rid=3184885&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FlMXJmftyMus%2Fnchembio.281 Authors: Sungwook Choi, Stephen Connelly, Natàlia Reixach, Ian A Wilson & Jeffery W Kelly (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184885 Sun, 20 Dec 2009 00:00:00 +0100 3184885 http://www.medworm.com/index.php?rid=3184880&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F154SQsWCMbM%2Fnchembio.282 Authors: Clinton T Morgan, Myon-Hee Lee & Judith Kimble Small molecules can control cell fate in vivo and may allow directed induction of desired cell types, providing an attractive alternative to transplant-based approaches in regenerative medicine. We have chemically induced functional oocytes in Caenorhabditis elegans adults that otherwise produced only sperm. These findings suggest that chemical approaches to therapeutic cell reprogramming may be feasible and provide a powerful platform for analyzing molecular mechanisms of in vivo cell reprogramming. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184880 Sun, 20 Dec 2009 00:00:00 +0100 3184880 http://www.medworm.com/index.php?rid=3184879&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FmXHpbuO9Cb0%2Fnchembio.285 We report the heterologous expression of rk genes in Saccharopolyspora erythraea and reconstitution of the RK-682 pathway using recombinant enzymes, and we show that RkD is the enzyme required for RK-682 formation from acyl carrier protein–bound substrates. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3184879 Sun, 20 Dec 2009 00:00:00 +0100 3184879 http://www.medworm.com/index.php?rid=3096038&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FrsUWiP61Z2Q%2Fnchembio.279 Authors: Susan W Liebman & Stephen C Meredith Aggregation of huntingtin protein with an expanded polyglutamine region is enhanced by its 17-residue N-terminal domain, which binds to itself and to the polyglutamine region. This enhancement is inhibited when the N-terminal domain binds to the chaperonin TRiC. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096038 Thu, 17 Dec 2009 15:56:17 +0100 3096038 http://www.medworm.com/index.php?rid=3096037&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FR5mwlCRTWus%2Fnchembio.287 Nature Chemical Biology 6, 5 (2010). doi:10.1038/nchembio.287 Author: Adrian R Ferré-D'Amaré Control of gene expression at the mRNA level is used extensively by cells. Now a biomimetic strategy yields a synthetic genetic switch in which an RNA-binding protein bound at the translation start site blocks progression of the ribosome. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096037 Thu, 17 Dec 2009 15:56:17 +0100 3096037 http://www.medworm.com/index.php?rid=3096036&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F-NtYb46Hfkg%2Fnchembio.288 Authors: Simon Kasif & Martin Steffen Complete and accurate annotation of gene function is an essential starting point for genome interpretation and a host of systems and synthetic biology endeavors. Detecting errors in existing annotation now has an important new tool. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096036 Thu, 17 Dec 2009 15:56:17 +0100 3096036 http://www.medworm.com/index.php?rid=3096035&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F83DofYC6Rn0%2Fnchembio.291 Nature Chemical Biology 6, 2 (2010). doi:10.1038/nchembio.291 (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096035 Thu, 17 Dec 2009 15:56:17 +0100 3096035 http://www.medworm.com/index.php?rid=3096034&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F7kRvazPuHww%2Fnchembio.292 Nature Chemical Biology 6, 1 (2010). doi:10.1038/nchembio.292 Nature Chemical Biology has a new look, with more online features to facilitate the communication of chemical biology discoveries. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096034 Thu, 17 Dec 2009 15:56:17 +0100 3096034 http://www.medworm.com/index.php?rid=3096039&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FxxJgvfdrc-E%2Fnchembio.286 Authors: Trent J Oman & Wilfred A van der Donk (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096039 Wed, 16 Dec 2009 00:00:00 +0100 3096039 http://www.medworm.com/index.php?rid=3096048&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FBKhMNYodOqc%2Fnchembio.273 Authors: Hirohide Saito, Tetsuhiro Kobayashi, Tomoaki Hara, Yoshihiko Fujita, Karin Hayashi, Rie Furushima & Tan Inoue (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096048 Sun, 13 Dec 2009 00:00:00 +0100 3096048 http://www.medworm.com/index.php?rid=3096047&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F_Cy5BiUulLc%2Fnchembio.276 Authors: Pierre-Pol Liebgott, Fanny Leroux, Bénédicte Burlat, Sébastien Dementin, Carole Baffert, Thomas Lautier, Vincent Fourmond, Pierre Ceccaldi, Christine Cavazza, Isabelle Meynial-Salles, Philippe Soucaille, Juan Carlos Fontecilla-Camps, Bruno Guigliarelli, Patrick Bertrand, Marc Rousset & Christophe Léger (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096047 Sun, 06 Dec 2009 00:00:00 +0100 3096047 http://www.medworm.com/index.php?rid=3096042&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FY5kcO5hMTjk%2Fnchembio.275 Authors: Darren M Hutt, David Herman, Ana P C Rodrigues, Sabrina Noel, Joseph M Pilewski, Jeanne Matteson, Ben Hoch, Wendy Kellner, Jeffery W Kelly, Andre Schmidt, Philip J Thomas, Yoshihiro Matsumura, William R Skach, Martina Gentzsch, John R Riordan, Eric J Sorscher, Tsukasa Okiyoneda, John R Yates, Gergely L Lukacs, Raymond A Frizzell, Gerard Manning, Joel M Gottesfeld & William E Balch (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096042 Sun, 06 Dec 2009 00:00:00 +0100 3096042 http://www.medworm.com/index.php?rid=3096046&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FP5uerm5D6Fg%2Fnchembio.274 Authors: Michael B Feldman, Daniel S Terry, Roger B Altman & Scott C Blanchard (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096046 Sun, 29 Nov 2009 00:00:00 +0100 3096046 http://www.medworm.com/index.php?rid=3096041&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F947nvMuBLp0%2Fnchembio.277 Authors: Jing Mi, Yingmiao Liu, Zahid N Rabbani, Zhongguang Yang, Johannes H Urban, Bruce A Sullenger & Bryan M Clary In an effort to target the in vivo context of tumor-specific moieties, we screened a large library of nuclease-resistant RNA oligonucleotides in tumor-bearing mice to identify candidate molecules with the ability to localize to hepatic colon cancer metastases. One of the selected molecules is an RNA aptamer that binds to p68, an RNA helicase that has been shown to be upregulated in colorectal cancer. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096041 Sun, 29 Nov 2009 00:00:00 +0100 3096041 http://www.medworm.com/index.php?rid=3096045&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FpxC381J4LZA%2Fnchembio.268 Authors: Holger Gerlach, Vanessa Laumann, Sascha Martens, Christian F W Becker, Roger S Goody & Matthias Geyer (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096045 Sun, 22 Nov 2009 00:00:00 +0100 3096045 http://www.medworm.com/index.php?rid=3096044&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FdYk3JnMqgNM%2Fnchembio.264 Authors: Eric C Carnes, DeAnna M Lopez, Niles P Donegan, Ambrose Cheung, Hattie Gresham, Graham S Timmins & C Jeffrey Brinker (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096044 Sun, 22 Nov 2009 00:00:00 +0100 3096044 http://www.medworm.com/index.php?rid=3096043&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FvXiGerBsELk%2Fnchembio.266 Authors: Tzu-Lin Hsiao, Olga Revelles, Lifeng Chen, Uwe Sauer & Dennis Vitkup (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096043 Sun, 22 Nov 2009 00:00:00 +0100 3096043 http://www.medworm.com/index.php?rid=3096040&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FslC6RFWBI_Y%2Fnchembio.265 Authors: Andrea K Werner, Tina Romeis & Claus-Peter Witte The availability of whole genome sequences boosts the identification of biochemical pathways conserved across species using tools of comparative genomics. A cross-organism protein association analysis allowed us to identify two enzymes, ureidoglycine aminohydrolase and ureidoglycolate amidohydrolase, that catalyze the final reactions of purine degradation in the model plant Arabidopsis thaliana. A similar pathway was found in Escherichia coli, while an alternative metabolic route via ureidoglycine transaminase can be predicted for other organisms. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=3096040 Sun, 22 Nov 2009 00:00:00 +0100 3096040 http://www.medworm.com/index.php?rid=2992334&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fx1yLPm_mOoM%2Fnchembio1209-954d Nature Chemical Biology 5, 954 (2009). doi:10.1038/nchembio1209-954d Author: David D Boehr, Ruth Nussinov & Peter E Wright (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992334 Sat, 14 Nov 2009 16:01:51 +0100 2992334 http://www.medworm.com/index.php?rid=2992333&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F-wFS2lkAXno%2Fnchembio1209-954c Nature Chemical Biology 5, 954 (2009). doi:10.1038/nchembio1209-954c Author: Erin K Schrader, Kristine G Harstad & Andreas Matouschek (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992333 Sat, 14 Nov 2009 16:01:51 +0100 2992333 http://www.medworm.com/index.php?rid=2992332&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FL463S6VU6ko%2Fnchembio1209-954b Nature Chemical Biology 5, 954 (2009). doi:10.1038/nchembio1209-954b Author: Stuart Cahalan & Hugh Rosen (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992332 Sat, 14 Nov 2009 16:01:51 +0100 2992332 http://www.medworm.com/index.php?rid=2992331&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F_zUXNrQr5r0%2Fnchembio1209-954a Nature Chemical Biology 5, 954 (2009). doi:10.1038/nchembio1209-954a Author: Florian Mullershausen, Frédéric Zecri, Cihan Cetin, Andreas Billich, Danilo Guerini & Klaus Seuwen (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992331 Sat, 14 Nov 2009 16:01:51 +0100 2992331 http://www.medworm.com/index.php?rid=2992318&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FgHNE80TzL5s%2Fnchembio.270 Nature Chemical Biology 5, 876 (2009). doi:10.1038/nchembio.270 (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992318 Sat, 14 Nov 2009 16:01:51 +0100 2992318 http://www.medworm.com/index.php?rid=2992317&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2ForNSW6a9Sv0%2Fnchembio.261 Authors: Naoko Takahashi-Makise, Diane McVey Ward & Jerry Kaplan Two iron regulatory proteins (IRP1 and IRP2) regulate translation and/or stability of mRNAs encoding proteins required for iron storage, acquisition and utilization. Rather than IRP2 directly sensing iron concentrations, iron has been shown to regulate the level of the SKP1-CUL1-FBXL5 E3 ubiquitin ligase protein complex, which is responsible for IRP2 degradation. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992317 Sat, 14 Nov 2009 16:01:51 +0100 2992317 http://www.medworm.com/index.php?rid=2992316&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F6ZU-3SY5uDY%2Fnchembio.262 Authors: Rebecca Toroney & Philip C Bevilacqua The RNA-activated protein kinase PKR inhibits translation initiation by sensing long viral double-stranded RNA. A new report indicates that PKR is also activated by a cellular mRNA, but only when ribosomes are not initiating translation. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992316 Sat, 14 Nov 2009 16:01:51 +0100 2992316 http://www.medworm.com/index.php?rid=2992315&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F-4EOQ8FYKAI%2Fnchembio.267 Nature Chemical Biology 5, 871 (2009). doi:10.1038/nchembio.267 Author: Andrei L Osterman A unique heterotrimeric assembly of individually inactive paralogs, two of which are also involved in regulating phosphatase activity, creates one of the key enzymes of coenzyme A biosynthesis in yeast, pointing to the possibility of a previously undescribed cross-talk between metabolic and signaling pathways. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992315 Sat, 14 Nov 2009 16:01:51 +0100 2992315 http://www.medworm.com/index.php?rid=2992314&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FpuHUi09YfGw%2Fnchembio.263 Nature Chemical Biology 5, 870 (2009). doi:10.1038/nchembio.263 Author: Vanessa Sperandio Vibrio cholerae produces cholera autoinducer-1 (CAI-1), a signaling molecule previously believed to be synthesized by the CqsA enzyme. Here it is shown that CqsA does not directly synthesize CAI-1; instead, it synthesizes amino-CAI-1, which is then converted into CAI-1 in a CqsA-independent manner. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992314 Sat, 14 Nov 2009 16:01:51 +0100 2992314 http://www.medworm.com/index.php?rid=2992313&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FB81u51l7OGw%2Fnchembio.260 Authors: Jon O Lundberg, Mark T Gladwin, Amrita Ahluwalia, Nigel Benjamin, Nathan S Bryan, Anthony Butler, Pedro Cabrales, Angela Fago, Martin Feelisch, Peter C Ford, Bruce A Freeman, Michael Frenneaux, Joel Friedman, Malte Kelm, Christopher G Kevil, Daniel B Kim-Shapiro, Andrey V Kozlov, Jack R Lancaster, David J Lefer, Kenneth McColl, Kenneth McCurry, Rakesh P Patel, Joel Petersson, Tienush Rassaf, Valentin P Reutov, George B Richter-Addo, Alan Schechter, Sruti Shiva, Koichiro Tsuchiya, Ernst E van Faassen, Andrew J Webb, Brian S Zuckerbraun, Jay L Zweier & Eddie Weitzberg Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator... Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992313 Sat, 14 Nov 2009 16:01:51 +0100 2992313 http://www.medworm.com/index.php?rid=2992312&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FT5_dcz4AiFk%2Fnchembio.272 Nature Chemical Biology 5, 863 (2009). doi:10.1038/nchembio.272 The third Nature Chemical Biology symposium brought together nearly 200 scientists to explore the frontiers of chemical biology and drug discovery. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992312 Sat, 14 Nov 2009 16:01:51 +0100 2992312 http://www.medworm.com/index.php?rid=2992311&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FCk_B2JSBwak%2Fnchembio.269 Nature Chemical Biology 5, v (2009). doi:10.1038/nchembio.269 (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992311 Sat, 14 Nov 2009 16:01:51 +0100 2992311 http://www.medworm.com/index.php?rid=2992321&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FPuNzfQsZTSE%2Fnchembio.252 Authors: Yu-Liang Yang, Yuquan Xu, Paul Straight & Pieter C Dorrestein Metabolic exchange between an organism and the environment, including interactions with neighboring organisms, is important for processes of organismal development. Here we develop and use thin-layer agar natural product MALDI-TOF imaging mass spectrometry of intact bacterial colonies grown on top of the MALDI target plate to study an interaction between two species of bacteria and provide direct evidence that Bacillus subtilis silences the defensive arsenal of Streptomyces coelicolor. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992321 Sun, 08 Nov 2009 00:00:00 +0100 2992321 http://www.medworm.com/index.php?rid=2992320&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FkioLTc4pizs%2Fnchembio.257 Authors: Marina Faiella, Concetta Andreozzi, Rafael Torres Martin de Rosales, Vincenzo Pavone, Ornella Maglio, Flavia Nastri, William F DeGrado & Angela Lombardi Here we report the de novo design and NMR structure of a four-helical bundle di-iron protein with phenol oxidase activity. The introduction of the cofactor-binding and phenol-binding sites required the incorporation of residues that were detrimental to the free energy of folding of the protein. Sufficient stability was, however, obtained by optimizing the sequence of a loop distant from the active site. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992320 Sun, 08 Nov 2009 00:00:00 +0100 2992320 http://www.medworm.com/index.php?rid=2992329&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FxGo8cyUYKPQ%2Fnchembio.246 Authors: Blake E Roberts, Martin L Duennwald, Huan Wang, Chan Chung, Nicholas P Lopreiato, Elizabeth A Sweeny, M Noelle Knight & James Shorter (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992329 Sun, 01 Nov 2009 00:00:00 +0100 2992329 http://www.medworm.com/index.php?rid=2992328&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fnat4sw1z6Tk%2Fnchembio.244 Authors: Hao Song, Stephen Payne, Meagan Gray & Lingchong You (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992328 Sun, 01 Nov 2009 00:00:00 +0100 2992328 http://www.medworm.com/index.php?rid=2992327&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F7OWzDvliHgc%2Fnchembio.243 Authors: Amparo Ruiz, Asier González, Ivan Muñoz, Raquel Serrano, J Albert Abrie, Erick Strauss & Joaquín Ariño (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992327 Sun, 01 Nov 2009 00:00:00 +0100 2992327 http://www.medworm.com/index.php?rid=2992330&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fqh-mlHzJK78%2Fnchembio.255 Authors: Philip R Effraim, Jiangning Wang, Michael T Englander, Josh Avins, Thomas S Leyh, Ruben L Gonzalez & Virginia W Cornish (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992330 Sun, 25 Oct 2009 00:00:00 +0100 2992330 http://www.medworm.com/index.php?rid=2992326&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FzAi4u8L9YxU%2Fnchembio.242 Authors: Lynette Cegelski, Jerome S Pinkner, Neal D Hammer, Corinne K Cusumano, Chia S Hung, Erik Chorell, Veronica Åberg, Jennifer N Walker, Patrick C Seed, Fredrik Almqvist, Matthew R Chapman & Scott J Hultgren (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992326 Sun, 25 Oct 2009 00:00:00 +0100 2992326 http://www.medworm.com/index.php?rid=2992322&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FAuPH6cHSk8A%2Fnchembio.259 We report a methodology for the ribosomal synthesis of backbone-cyclized peptides involving genetic code reprogramming to introduce one or more nonproteinogenic amino acids. Expression of linear peptides bearing a cysteine-proline dipeptide sequence followed by glycolic acid results in self-rearrangement to a C-terminal diketopiperadine-thioester, which non-enzymatically generates a cyclized peptide. We demonstrate the ribosomal synthesis of several naturally occurring backbone-cyclized peptides and a library based on a bicyclic scaffold, and we identify bioactive sequences by screening and deconvolution. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992322 Sun, 25 Oct 2009 00:00:00 +0100 2992322 http://www.medworm.com/index.php?rid=2908055&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F4-hcCHMNgro%2Fnchembio.253 Nature Chemical Biology 5, 786 (2009). doi:10.1038/nchembio.253 (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908055 Tue, 20 Oct 2009 15:13:43 +0100 2908055 http://www.medworm.com/index.php?rid=2908054&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FA9BtcY6AoQ4%2Fnchembio.248 Nature Chemical Biology 5, 784 (2009). doi:10.1038/nchembio.248 Author: Keith Shearwin Synthetic biologists aim to rationally design and construct useful biological circuits. However, perturbation of host cell physiology, through the very process of turning on an artificial circuit, can give rise to unexpected emergent behaviors, such as bistability. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908054 Tue, 20 Oct 2009 15:13:43 +0100 2908054 http://www.medworm.com/index.php?rid=2908053&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F9Jm3xztI0T0%2Fnchembio.247 Nature Chemical Biology 5, 783 (2009). doi:10.1038/nchembio.247 Author: Jay T Groves Membrane curvature sensing by amphipathic helices is an emergent property of the ensemble of molecules and membrane sites. New data suggest that individual molecules do not experience stronger binding to curved membranes. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908053 Tue, 20 Oct 2009 15:13:43 +0100 2908053 http://www.medworm.com/index.php?rid=2908052&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fb-hyvdGoGHQ%2Fnchembio.245 Authors: Darren W Begley & Gabriele Varani Few antimicrobial drugs function by directly targeting RNA. A small molecule that binds the hepatitis C viral genome by 'locking' in a particular RNA conformation to inhibit viral protein production suggests a new paradigm for drug design. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908052 Tue, 20 Oct 2009 15:13:43 +0100 2908052 http://www.medworm.com/index.php?rid=2908051&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fk9vzBQRV2iM%2Fnchembio.233 We describe here a model wherein a group of 'nanny' proteins function to protect newly synthesized IDPs from degradation by default, thereby insuring their maturation into important regulatory molecules. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908051 Tue, 20 Oct 2009 15:13:43 +0100 2908051 http://www.medworm.com/index.php?rid=2908050&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FplNrdZCwr1c%2Fnchembio.241 Authors: Lila M Gierasch & Anne Gershenson In their native environments, proteins perform their biological roles in highly concentrated viscous solutions and in complex networks with numerous partners. Yet for many years, the normal practice has been to purify a protein of interest in order to characterize its structural and functional properties. In this Commentary, we discuss how protein scientists are now tackling the theoretical and methodological challenges of studying proteins in their physiological context. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908050 Tue, 20 Oct 2009 15:13:43 +0100 2908050 http://www.medworm.com/index.php?rid=2908049&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fv51NXpaIxvk%2Fnchembio.258 Nature Chemical Biology 5, 773 (2009). doi:10.1038/nchembio.258 Understanding how proteins function in isolation and in their native context requires a merging of molecular-level techniques that explore the interplay of protein structure and dynamics. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908049 Tue, 20 Oct 2009 15:13:43 +0100 2908049 http://www.medworm.com/index.php?rid=2908048&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FSk3EVPU48zk%2Fnchembio.254 Nature Chemical Biology 5, v (2009). doi:10.1038/nchembio.254 (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908048 Tue, 20 Oct 2009 15:13:43 +0100 2908048 http://www.medworm.com/index.php?rid=2908059&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FTjRD09gXzP8%2Fnchembio.250 Authors: Erin K Schrader, Kristine G Harstad & Andreas Matouschek (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908059 Sun, 18 Oct 2009 23:00:00 +0100 2908059 http://www.medworm.com/index.php?rid=2908058&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F6f28Mjlui2g%2Fnchembio.238 Authors: Andrew J Baldwin & Lewis E Kay (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908058 Sun, 18 Oct 2009 23:00:00 +0100 2908058 http://www.medworm.com/index.php?rid=2908057&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FcUgCn3sECHQ%2Fnchembio.251 Authors: Daniel J Mandell & Tanja Kortemme (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908057 Sun, 18 Oct 2009 23:00:00 +0100 2908057 http://www.medworm.com/index.php?rid=2992325&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F--iAZ75Yb3c%2Fnchembio.236 Authors: Maria Manosas, Michelle M Spiering, Zhihao Zhuang, Stephen J Benkovic & Vincent Croquette (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992325 Sun, 18 Oct 2009 00:00:00 +0100 2992325 http://www.medworm.com/index.php?rid=2992323&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F4HeuyCxOgTw%2Fnchembio.237 Authors: Robert C Kelly, Megan E Bolitho, Douglas A Higgins, Wenyun Lu, Wai-Leung Ng, Philip D Jeffrey, Joshua D Rabinowitz, Martin F Semmelhack, Frederick M Hughson & Bonnie L Bassler (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992323 Sun, 18 Oct 2009 00:00:00 +0100 2992323 http://www.medworm.com/index.php?rid=2992319&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FzwaeJcCR_sA%2Fnchembio.235 Authors: Y Grace Chen, Walter E Kowtoniuk, Isha Agarwal, Yinghua Shen & David R Liu We developed a general method to detect cellular small molecule–RNA conjugates that does not rely on the reactivity of the small molecule. This technique revealed NAD-linked RNA in Escherichia coli and Streptomyces venezuelae. Subsequent characterization showed that NAD is a 5′ modification of RNA, cannot be installed in vitro through aberrant transcriptional initiation, is only found among smaller cellular RNAs and is present at a surprisingly high abundance of ∼3,000 copies per cell. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992319 Sun, 11 Oct 2009 00:00:00 +0100 2992319 http://www.medworm.com/index.php?rid=2908056&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FfDXGmdep7hA%2Fnchembio.232 Authors: David D Boehr, Ruth Nussinov & Peter E Wright (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908056 Fri, 09 Oct 2009 23:00:00 +0100 2908056 http://www.medworm.com/index.php?rid=2992324&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FT7qon5Ao5JA%2Fnchembio.234 Dynamic refolding of IFN-γ mRNA enables it to function as PKR activator and translation template Nature Chemical Biology 5, 896 (2009). doi:10.1038/nchembio.234 Authors: Smadar Cohen-Chalamish, Anat Hasson, Dahlia Weinberg, Lise Sarah Namer, Yona Banai, Farhat Osman & Raymond Kaempfer (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2992324 Sun, 04 Oct 2009 00:00:00 +0100 2992324 http://www.medworm.com/index.php?rid=2908063&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fvi1x0H5JMAk%2Fnchembio.218 Authors: Cheemeng Tan, Philippe Marguet & Lingchong You (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908063 Sat, 03 Oct 2009 23:00:00 +0100 2908063 http://www.medworm.com/index.php?rid=2908064&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fyxe-BCNQMPA%2Fnchembio.221 Authors: Ranjana Pathania, Soumaya Zlitni, Courtney Barker, Rahul Das, David A Gerritsma, Julie Lebert, Emilia Awuah, Giuseppe Melacini, Fred A Capretta & Eric D Brown (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908064 Sat, 26 Sep 2009 23:00:00 +0100 2908064 http://www.medworm.com/index.php?rid=2827567&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FlhaSbHndeNk%2Fnchembio1009-772 Nature Chemical Biology 5, 772 (2009). doi:10.1038/nchembio1009-772 Author: Matthew A Clark, Raksha A Acharya, Christopher C Arico-Muendel, Svetlana L Belyanskaya, Dennis R Benjamin, Neil R Carlson, Paolo A Centrella, Cynthia H Chiu, Steffen P Creaser, John W Cuozzo, Christopher P Davie, Yun Ding, G Joseph Franklin, Kurt D Franzen, Malcolm L Gefter, Steven P Hale, Nils J V Hansen, David I Israel, Jinwei Jiang, Malcolm J Kavarana, Michael S Kelley, Christopher S Kollmann, Fan Li, Kenneth Lind, Sibongile Mataruse, Patricia F Medeiros, Jeffrey A Messer, Paul Myers, Heather O'Keefe, Matthew C Oliff, Cecil E Rise, Alexander L Satz, Steven R Skinner, Jennifer L Svendsen, Lujia Tang, Kurt van Vloten, Richard W Wagner, Gang Yao, Baoguang Zhao & Barry A Morgan (Source: Nature Chemical Biolog... Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2827567 Thu, 24 Sep 2009 17:50:21 +0100 2827567 http://www.medworm.com/index.php?rid=2827556&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FT9s_zriUYVo%2Fnchembio.230 Nature Chemical Biology 5, 712 (2009). doi:10.1038/nchembio.230 (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2827556 Thu, 24 Sep 2009 17:50:21 +0100 2827556 http://www.medworm.com/index.php?rid=2827555&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F7EMJhmhJZVo%2Fnchembio.224 Authors: Mostafa I Fekry & Kent S Gates Hydrolysis of the phosphodiester linkages in DNA is a notoriously difficult reaction. Deoxyribozymes that use Zn2+ and Mn2+ ions to accelerate this reaction by a factor of one hundred million (or more) have been identified and characterized. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2827555 Thu, 24 Sep 2009 17:50:21 +0100 2827555 http://www.medworm.com/index.php?rid=2827554&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FmCDeYEavwpA%2Fnchembio.226 Authors: Anna Rubartelli & Roberto Sitia Chemo-metabolic processes such as redox remodeling and amino acid availability act as immunity rheostats, revealing a new mechanism regulating intercellular cross-talk between dendritic cells, regulatory T lymphocytes and effector T lymphocytes. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2827554 Thu, 24 Sep 2009 17:50:21 +0100 2827554 http://www.medworm.com/index.php?rid=2827553&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FMwE5jcW1pkI%2Fnchembio.225 Nature Chemical Biology 5, 707 (2009). doi:10.1038/nchembio.225 Author: Michael Rosenblatt Parathyroid hormone (PTH) and PTH-related protein activate the same receptor but can produce divergent effects. Reports now describe two active conformations for the PTH receptor, one of which moves intracellularly—complexed with hormone and G protein—to produce a continued cAMP signal. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2827553 Thu, 24 Sep 2009 17:50:21 +0100 2827553 http://www.medworm.com/index.php?rid=2827552&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FlvMnNAzV5Ig%2Fnchembio.229 Authors: Shay Tal & Johan Paulsson (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2827552 Thu, 24 Sep 2009 17:50:21 +0100 2827552 http://www.medworm.com/index.php?rid=2827551&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FhPmg9pm9eg0%2Fnchembio.222 Authors: Emma McCullagh, Justin Farlow, Christopher Fuller, Juliet Girard, Joanna Lipinski-Kruszka, Dan Lu, Thomas Noriega, Geoffrey Rollins, Russell Spitzer, Michael Todhunter & Hana El-Samad (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2827551 Thu, 24 Sep 2009 17:50:21 +0100 2827551 http://www.medworm.com/index.php?rid=2827550&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FTdptmXpgzMI%2Fnchembio.f.13 Nature Chemical Biology 5, 697 (2009). doi:10.1038/nchembio.f.13 New policies refine the responsibilities of authors and require author contribution statements in Nature Chemical Biology research papers. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2827550 Thu, 24 Sep 2009 17:50:21 +0100 2827550 http://www.medworm.com/index.php?rid=2827549&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F22ALLRW8x4o%2Fnchembio.231 Nature Chemical Biology 5, v (2009). doi:10.1038/nchembio.231 (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2827549 Thu, 24 Sep 2009 17:50:21 +0100 2827549 http://www.medworm.com/index.php?rid=2818962&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FKLSJEWDBbDE%2Fnchembio0909-696c Nature Chemical Biology 5, 696 (2009). doi:10.1038/nchembio0909-696c Author: Zachary D Nagel & Judith P Klinman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2818962 Tue, 22 Sep 2009 17:54:34 +0100 2818962 http://www.medworm.com/index.php?rid=2818961&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FiAtGP9zuvuk%2Fnchembio0909-696b Nature Chemical Biology 5, 696 (2009). doi:10.1038/nchembio0909-696b Author: Stefan Wetzel, Karsten Klein, Steffen Renner, Daniel Rauh, Tudor I Oprea, Petra Mutzel & Herbert Waldmann (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2818961 Tue, 22 Sep 2009 17:54:34 +0100 2818961 http://www.medworm.com/index.php?rid=2818960&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FAgYS4WvfPtk%2Fnchembio0909-696a Nature Chemical Biology 5, 696 (2009). doi:10.1038/nchembio0909-696a Author: Jin Woo Bok, Yi-Ming Chiang, Edyta Szewczyk, Yazmid Reyes-Dominguez, Ashley D Davidson, James F Sanchez, Hsien-Chun Lo, Kenji Watanabe, Joseph Strauss, Berl R Oakley, Clay C C Wang & Nancy P Keller (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2818960 Tue, 22 Sep 2009 17:54:34 +0100 2818960 http://www.medworm.com/index.php?rid=2818948&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FuxZ7CZH1HiE%2Fnchembio0909-614 Nature Chemical Biology 5, 614 (2009). doi:10.1038/nchembio0909-614 (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2818948 Tue, 22 Sep 2009 17:54:34 +0100 2818948 http://www.medworm.com/index.php?rid=2818947&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FJKOpqmnCagw%2Fnchembio0909-612 Authors: Ding Xu & Jeffrey D Esko One of the primary functions of the Golgi apparatus is the assembly of glycans on macromolecules destined for secretion or the plasma membrane. A recent study describes the first step toward an artificial Golgi, based on a microfluidic chip and magnetic nanoparticles. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2818947 Tue, 22 Sep 2009 17:54:34 +0100 2818947 http://www.medworm.com/index.php?rid=2818946&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FNY0zRwz2jDc%2Fnchembio0909-611 Nature Chemical Biology 5, 611 (2009). doi:10.1038/nchembio0909-611 Author: Eugene G Mueller A cocrystal structure of the enzyme that synthesizes selenocysteine reveals the elegantly simple recognition mechanism for the tRNA molecule for this '21st amino acid'. The structure resolves some mechanistic questions and allows for comparison of the tRNA-dependent synthesis of cysteine and selenocysteine. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2818946 Tue, 22 Sep 2009 17:54:34 +0100 2818946 http://www.medworm.com/index.php?rid=2818945&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FEUM_rfuHGB4%2Fnchembio0909-609 Nature Chemical Biology 5, 609 (2009). doi:10.1038/nchembio0909-609 Author: Charles P Scott Screening a library of expressed cyclic peptides identified clones that reverse the cytotoxicity of α-synuclein in yeast and Caenorhabditis elegans. The results suggest a new approach for intervention in Parkinson's disease, and perhaps a druggable target. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2818945 Tue, 22 Sep 2009 17:54:34 +0100 2818945 http://www.medworm.com/index.php?rid=2818944&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FIp4skTpkKKg%2Fnchembio0909-608 Authors: Peter Zylbergold & Terence E Hébert The functional architecture of dimeric or oligomeric GPCR signaling remains incompletely understood. Using a clever combination of receptor–G protein fusions and various receptor mutations, new research provides a glimpse into how oligomers might be arranged with respect to the G proteins they interact with. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2818944 Tue, 22 Sep 2009 17:54:34 +0100 2818944 http://www.medworm.com/index.php?rid=2818943&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FJJCWEaTCFSs%2Fnchembio0909-607 Nature Chemical Biology 5, 607 (2009). doi:10.1038/nchembio0909-607 Author: Jean Chmielewski A small-molecule inhibitor of the obligate dimeric protease of human Kaposi's sarcoma–associated herpesvirus was identified. The agent functions by a 'monomer trap' mechanism in which the compound binds to a partially unfolded monomer and disrupts the formation of the enzymatically active protease dimer. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2818943 Tue, 22 Sep 2009 17:54:34 +0100 2818943 http://www.medworm.com/index.php?rid=2818942&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FLVUvJqQjPjE%2Fnchembio0909-602 Authors: H Alex Brown & Robert C Murphy (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2818942 Tue, 22 Sep 2009 17:54:34 +0100 2818942 http://www.medworm.com/index.php?rid=2818941&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FWTldZiMiE1I%2Fnchembio0909-601 #science communication Nature Chemical Biology 5, 601 (2009). doi:10.1038/nchembio0909-601 How do we foster open scientific dialog in the digital age while respecting the integrity of the scientific process? (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2818941 Tue, 22 Sep 2009 17:54:34 +0100 2818941 http://www.medworm.com/index.php?rid=2818940&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FKeqqX8q8XBw%2Fnchembio0909-v Nature Chemical Biology 5, v (2009). doi:10.1038/nchembio0909-v (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2818940 Tue, 22 Sep 2009 17:54:34 +0100 2818940 http://www.medworm.com/index.php?rid=2908065&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FqHpy1F8mNr8%2Fnchembio.220 Authors: Vincent Dupres, David Alsteens, Sabrina Wilk, Benjamin Hansen, Jürgen J Heinisch & Yves F Dufrêne (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908065 Sat, 19 Sep 2009 23:00:00 +0100 2908065 http://www.medworm.com/index.php?rid=2908060&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fqj3e-JBbBfw%2Fnchembio.217 Authors: Jerod Parsons, M Paola Castaldi, Sanjay Dutta, Sergey M Dibrov, David L Wyles & Thomas Hermann The internal ribosome entry site (IRES), a highly conserved structured element of the hepatitis C virus (HCV) genomic RNA, is an attractive target for antiviral drugs. Here we show that benzimidazole inhibitors of the HCV replicon act by conformational induction of a widened interhelical angle in the IRES subdomain IIa, which facilitates the undocking of subdomain IIb from the ribosome and ultimately leads to inhibition of IRES-driven translation in HCV-infected cells. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908060 Sat, 19 Sep 2009 23:00:00 +0100 2908060 http://www.medworm.com/index.php?rid=2807085&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnchembio1009-772 Nature Chemical Biology 5, 772 (2009). doi:10.1038/nchembio1009-772 Author: Matthew A Clark, Raksha A Acharya, Christopher C Arico-Muendel, Svetlana L Belyanskaya, Dennis R Benjamin, Neil R Carlson, Paolo A Centrella, Cynthia H Chiu, Steffen P Creaser, John W Cuozzo, Christopher P Davie, Yun Ding, G Joseph Franklin, Kurt D Franzen, Malcolm L Gefter, Steven P Hale, Nils J V Hansen, David I Israel, Jinwei Jiang, Malcolm J Kavarana, Michael S Kelley, Christopher S Kollmann, Fan Li, Kenneth Lind, Sibongile Mataruse, Patricia F Medeiros, Jeffrey A Messer, Paul Myers, Heather O'Keefe, Matthew C Oliff, Cecil E Rise, Alexander L Satz, Steven R Skinner, Jennifer L Svendsen, Lujia Tang, Kurt van Vloten, Richard W Wagner, Gang Yao, Baoguang Zhao & Barry A Morgan (Source: Nature Chemical Biolog... Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2807085 Fri, 18 Sep 2009 17:42:07 +0100 2807085 http://www.medworm.com/index.php?rid=2807074&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnchembio.230 Nature Chemical Biology 5, 712 (2009). doi:10.1038/nchembio.230 (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2807074 Fri, 18 Sep 2009 17:42:07 +0100 2807074 http://www.medworm.com/index.php?rid=2807073&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnchembio.224 Authors: Mostafa I Fekry & Kent S Gates Hydrolysis of the phosphodiester linkages in DNA is a notoriously difficult reaction. Deoxyribozymes that use Zn2+ and Mn2+ ions to accelerate this reaction by a factor of one hundred million (or more) have been identified and characterized. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2807073 Fri, 18 Sep 2009 17:42:07 +0100 2807073 http://www.medworm.com/index.php?rid=2807072&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnchembio.226 Authors: Anna Rubartelli & Roberto Sitia Chemo-metabolic processes such as redox remodeling and amino acid availability act as immunity rheostats, revealing a new mechanism regulating intercellular cross-talk between dendritic cells, regulatory T lymphocytes and effector T lymphocytes. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2807072 Fri, 18 Sep 2009 17:42:07 +0100 2807072 http://www.medworm.com/index.php?rid=2807071&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnchembio.225 Nature Chemical Biology 5, 707 (2009). doi:10.1038/nchembio.225 Author: Michael Rosenblatt Parathyroid hormone (PTH) and PTH-related protein activate the same receptor but can produce divergent effects. Reports now describe two active conformations for the PTH receptor, one of which moves intracellularly—complexed with hormone and G protein—to produce a continued cAMP signal. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2807071 Fri, 18 Sep 2009 17:42:06 +0100 2807071 http://www.medworm.com/index.php?rid=2807070&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnchembio.229 Authors: Shay Tal & Johan Paulsson (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2807070 Fri, 18 Sep 2009 17:42:06 +0100 2807070 http://www.medworm.com/index.php?rid=2807069&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnchembio.222 Authors: Emma McCullagh, Justin Farlow, Christopher Fuller, Juliet Girard, Joanna Lipinski-Kruszka, Dan Lu, Thomas Noriega, Geoffrey Rollins, Russell Spitzer, Michael Todhunter & Hana El-Samad (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2807069 Fri, 18 Sep 2009 17:42:06 +0100 2807069 http://www.medworm.com/index.php?rid=2807068&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnchembio.f.13 Nature Chemical Biology 5, 697 (2009). doi:10.1038/nchembio.f.13 New policies refine the responsibilities of authors and require author contribution statements in Nature Chemical Biology research papers. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2807068 Fri, 18 Sep 2009 17:42:06 +0100 2807068 http://www.medworm.com/index.php?rid=2807067&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnchembio.231 Nature Chemical Biology 5, v (2009). doi:10.1038/nchembio.231 (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2807067 Fri, 18 Sep 2009 17:42:06 +0100 2807067 http://www.medworm.com/index.php?rid=2908062&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F3rtFmgc4n0w%2Fnchembio.213 Authors: Nikos S Hatzakis, Vikram K Bhatia, Jannik Larsen, Kenneth L Madsen, Pierre-Yves Bolinger, Andreas H Kunding, John Castillo, Ulrik Gether, Per Hedegård & Dimitrios Stamou (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2908062 Sat, 12 Sep 2009 23:00:00 +0100 2908062 http://www.medworm.com/index.php?rid=2827566&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FJfiC35bN_pM%2Fnchembio.215 Authors: Jing Yuan, Ronald L Johnson, Ruili Huang, Jennifer Wichterman, Hongying Jiang, Karen Hayton, David A Fidock, Thomas E Wellems, James Inglese, Christopher P Austin & Xin-zhuan Su (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2827566 Sat, 05 Sep 2009 23:00:00 +0100 2827566 http://www.medworm.com/index.php?rid=2827563&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FupNOLC5qMZA%2Fnchembio.207 A synthetic CD4–heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry Nature Chemical Biology 5, 743 (2009). doi:10.1038/nchembio.207 Authors: Françoise Baleux, Latino Loureiro-Morais, Yael Hersant, Pascal Clayette, Fernando Arenzana-Seisdedos, David Bonnaffé & Hugues Lortat-Jacob (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2827563 Sat, 05 Sep 2009 23:00:00 +0100 2827563 http://www.medworm.com/index.php?rid=2827560&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FU9kNxd1TieI%2Fnchembio.214 Authors: Yixin Zhang, Frank Erdmann & Gunter Fischer Reversible and non-invasive photoswitching of the immunosuppressive effect of a drug would be a very valuable tool for precisely regulating the immune system. Using a combination of protein borrowing and two-photon photoisomerization, we designed and synthesized derivatives of cyclosporin A. Here we demonstrate photoswitching of the local conformation within small molecules, which we used to modulate inhibitory potencies for cyclophilin, influence ternary and quaternary complex formations and regulate T-cell transcriptional activation in situ. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2827560 Sat, 05 Sep 2009 23:00:00 +0100 2827560 http://www.medworm.com/index.php?rid=2807084&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnchembio.215 Authors: Jing Yuan, Ronald L Johnson, Ruili Huang, Jennifer Wichterman, Hongying Jiang, Karen Hayton, David A Fidock, Thomas E Wellems, James Inglese, Christopher P Austin & Xin-zhuan Su (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2807084 Sat, 05 Sep 2009 23:00:00 +0100 2807084 http://www.medworm.com/index.php?rid=2807081&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnchembio.207 A synthetic CD4–heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry Nature Chemical Biology 5, 743 (2009). doi:10.1038/nchembio.207 Authors: Françoise Baleux, Latino Loureiro-Morais, Yael Hersant, Pascal Clayette, Fernando Arenzana-Seisdedos, David Bonnaffé & Hugues Lortat-Jacob (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=2807081 Sat, 05 Sep 2009 23:00:00 +0100 2807081