Nature Chemical Biology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nature Chemical Biology' source. Thu, 09 Feb 2012 14:32:13 +0100 Signaling: An oxysterol ligand for Smoothened http://www.medworm.com/index.php?rid=5603797&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FnVcJCXuEsEQ%2Fnchembio.774 Authors: Hayley J Sharpe & Frederic J de Sauvage 20(S)-hydroxycholesterol, a naturally occurring oxysterol, activates the Hedgehog signaling pathway by directly binding an allosteric site on Smoothened. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603797 Wed, 18 Jan 2012 05:00:00 +0100 5603797 Glycobiology: Enzyme deficiencies deciphered http://www.medworm.com/index.php?rid=5603796&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FUTMd2o2J4rk%2Fnchembio.778 Nature Chemical Biology 8, 137 (2012). doi:10.1038/nchembio.778 Author: Lena Kjellén Mucopolysaccharidoses are inherited disorders in which inactivation of lysosomal enzymes results in accumulation of glycosaminoglycans within cells, causing tissue and organ dysfunction. A method to determine the unique end structures of the accumulated glycosaminoglycans offers a new way for diagnosis. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603796 Wed, 18 Jan 2012 05:00:00 +0100 5603796 Ion channels: Cooperativity in twin gatings http://www.medworm.com/index.php?rid=5603795&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fx1tkjI9ouoY%2Fnchembio.776 Nature Chemical Biology 8, 136 (2012). doi:10.1038/nchembio.776 Author: Lei Zhou Patch-clamp fluorometry measurements of cAMP binding and channel opening combined with global kinetic fitting revealed that ligand binding to the tetrameric hyperpolarization-activated cyclic nucleotide–gated channel is favored at the second and fourth binding events. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603795 Wed, 18 Jan 2012 05:00:00 +0100 5603795 Chemical genetics: Bumping into AMPK substrates http://www.medworm.com/index.php?rid=5603794&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FfTmnxpt4XpM%2Fnchembio.789 Nature Chemical Biology 8, 135 (2012). doi:10.1038/nchembio.789 Author: Terry L. Sheppard (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603794 Wed, 18 Jan 2012 05:00:00 +0100 5603794 Molecular switches: The pore of the matter http://www.medworm.com/index.php?rid=5603793&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F3YsoWuS-F9Y%2Fnchembio.788 Nature Chemical Biology 8, 135 (2012). doi:10.1038/nchembio.788 Author: Mirella Bucci (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603793 Wed, 18 Jan 2012 05:00:00 +0100 5603793 Translation: Ribosome 3.0 http://www.medworm.com/index.php?rid=5603792&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fa0shsD0duHM%2Fnchembio.787 Nature Chemical Biology 8, 135 (2012). doi:10.1038/nchembio.787 Author: Amy Donner (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603792 Wed, 18 Jan 2012 05:00:00 +0100 5603792 Metabolism: Closing the loop http://www.medworm.com/index.php?rid=5603791&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FSDS1Cu5ygms%2Fnchembio.786 Nature Chemical Biology 8, 135 (2012). doi:10.1038/nchembio.786 Author: Catherine Goodman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603791 Wed, 18 Jan 2012 05:00:00 +0100 5603791 Allostery: A systematic search http://www.medworm.com/index.php?rid=5603790&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fl9Ix4zh6k1o%2Fnchembio.785 Nature Chemical Biology 8, 134 (2012). doi:10.1038/nchembio.785 Author: Catherine Goodman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603790 Wed, 18 Jan 2012 05:00:00 +0100 5603790 Methods: Zebrafish click http://www.medworm.com/index.php?rid=5603789&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FA1Y70mXBhq4%2Fnchembio.784 Nature Chemical Biology 8, 134 (2012). doi:10.1038/nchembio.784 Author: Mirella Bucci (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603789 Wed, 18 Jan 2012 05:00:00 +0100 5603789 Enzyme engineering: Just a jump to the left http://www.medworm.com/index.php?rid=5603788&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FT_Z3-IYPaGE%2Fnchembio.783 Nature Chemical Biology 8, 134 (2012). doi:10.1038/nchembio.783 Author: Joshua M. Finkelstein (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603788 Wed, 18 Jan 2012 05:00:00 +0100 5603788 Protein-protein interactions: In the TANK http://www.medworm.com/index.php?rid=5603787&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FzBq_sGx2O3U%2Fnchembio.782 Nature Chemical Biology 8, 134 (2012). doi:10.1038/nchembio.782 Author: Amy Donner (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603787 Wed, 18 Jan 2012 05:00:00 +0100 5603787 Oxysterols are allosteric activators of the oncoprotein Smoothened http://www.medworm.com/index.php?rid=5603808&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FDiKXE0UAAF4%2Fnchembio.765 Authors: Sigrid Nachtergaele, Laurel K Mydock, Kathiresan Krishnan, Jayan Rammohan, Paul H Schlesinger, Douglas F Covey & Rajat Rohatgi (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603808 Sun, 08 Jan 2012 05:00:00 +0100 5603808 Timing facilitated site transfer of an enzyme on DNA http://www.medworm.com/index.php?rid=5603807&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FFeS6q7S8I7k%2Fnchembio.764 Authors: Joseph D Schonhoft & James T Stivers (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603807 Sun, 08 Jan 2012 05:00:00 +0100 5603807 Disease-specific non–reducing end carbohydrate biomarkers for mucopolysaccharidoses http://www.medworm.com/index.php?rid=5603806&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fl_yCgzd8Lfo%2Fnchembio.766 Authors: Roger Lawrence, Jillian R Brown, Kanar Al-Mafraji, William C Lamanna, James R Beitel, Geert-Jan Boons, Jeffrey D Esko & Brett E Crawford (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603806 Sun, 08 Jan 2012 05:00:00 +0100 5603806 Small-molecule proteostasis regulators for protein conformational diseases http://www.medworm.com/index.php?rid=5603805&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FxkTJG90laa8%2Fnchembio.763 Authors: Barbara Calamini, Maria Catarina Silva, Franck Madoux, Darren M Hutt, Shilpi Khanna, Monica A Chalfant, S Adrian Saldanha, Peter Hodder, Bradley D Tait, Dan Garza, William E Balch & Richard I Morimoto (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603805 Sun, 25 Dec 2011 05:00:00 +0100 5603805 Natural product–inspired cascade synthesis yields modulators of centrosome integrity http://www.medworm.com/index.php?rid=5603804&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FYxi6Cf5j_2A%2Fnchembio.758 Authors: Heiko Dückert, Verena Pries, Vivek Khedkar, Sascha Menninger, Hanna Bruss, Alexander W Bird, Zoltan Maliga, Andreas Brockmeyer, Petra Janning, Anthony Hyman, Stefan Grimme, Markus Schürmann, Hans Preut, Katja Hübel, Slava Ziegler, Kamal Kumar & Herbert Waldmann (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603804 Sun, 25 Dec 2011 05:00:00 +0100 5603804 Primary amines protect against retinal degeneration in mouse models of retinopathies http://www.medworm.com/index.php?rid=5603803&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FTxCS_ZgTvPU%2Fnchembio.759 Authors: Akiko Maeda, Marcin Golczak, Yu Chen, Kiichiro Okano, Hideo Kohno, Satomi Shiose, Kaede Ishikawa, William Harte, Grazyna Palczewska, Tadao Maeda & Krzysztof Palczewski (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603803 Sun, 25 Dec 2011 05:00:00 +0100 5603803 Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor http://www.medworm.com/index.php?rid=5603798&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fw-FLUSjcQ14%2Fnchembio.761 We describe the design of skepinone-L, which is, to our knowledge, the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, skepinone-L is a valuable probe for chemical biology research, and it may foster the development of a unique class of kinase inhibitors. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603798 Sun, 25 Dec 2011 05:00:00 +0100 5603798 How subunits cooperate in cAMP-induced activation of homotetrameric HCN2 channels http://www.medworm.com/index.php?rid=5603802&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Ftl-QTi4ClxA%2Fnchembio.747 Authors: Jana Kusch, Susanne Thon, Eckhard Schulz, Christoph Biskup, Vasilica Nache, Thomas Zimmer, Reinhard Seifert, Frank Schwede & Klaus Benndorf (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603802 Sun, 18 Dec 2011 05:00:00 +0100 5603802 A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis http://www.medworm.com/index.php?rid=5603801&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FOrV9aNi9Usw%2Fnchembio.746 Authors: Tom Bretschneider, Georg Zocher, Michelle Unger, Kirstin Scherlach, Thilo Stehle & Christian Hertweck (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603801 Sun, 18 Dec 2011 05:00:00 +0100 5603801 Knot formation in newly translated proteins is spontaneous and accelerated by chaperonins http://www.medworm.com/index.php?rid=5603800&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FWuE7ZJOLGqI%2Fnchembio.742 Authors: Anna L Mallam & Sophie E Jackson (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603800 Sun, 18 Dec 2011 05:00:00 +0100 5603800 Chemical informatics and target identification in a zebrafish phenotypic screen http://www.medworm.com/index.php?rid=5603799&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F7QKAc976_js%2Fnchembio.732 Authors: Christian Laggner, David Kokel, Vincent Setola, Alexandra Tolia, Henry Lin, John J Irwin, Michael J Keiser, Chung Yan J Cheung, Daniel L Minor, Bryan L Roth, Randall T Peterson & Brian K Shoichet Target identification is a core challenge in chemical genetics. Here we use chemical similarity to computationally predict the targets of 586 compounds that were active in a zebrafish behavioral assay. Among 20 predictions tested, 11 compounds had activities ranging from 1 nM to 10,000 nM on the predicted targets. The roles of two of these targets were tested in the original zebrafish phenotype. Prediction of targets from chemotype is rapid and may be generally applicable. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5603799 Sun, 18 Dec 2011 05:00:00 +0100 5603799 Bugs, drugs and chemical genomics http://www.medworm.com/index.php?rid=5512234&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FhlwdxRWumRM%2Fnchembio.744 Authors: Terry Roemer, Julian Davies, Guri Giaever & Corey Nislow (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512234 Thu, 15 Dec 2011 05:00:00 +0100 5512234 Bacteria and host interactions in the gut epithelial barrier http://www.medworm.com/index.php?rid=5512233&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FZmEqSk70t_I%2Fnchembio.741 Authors: Hiroshi Ashida, Michinaga Ogawa, Minsoo Kim, Hitomi Mimuro & Chihiro Sasakawa (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512233 Thu, 15 Dec 2011 05:00:00 +0100 5512233 Microbial metabolic exchange—the chemotype-to-phenotype link http://www.medworm.com/index.php?rid=5512232&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FuAZuIIVxGKk%2Fnchembio.739 Microbial metabolic exchange—the chemotype-to-phenotype link Nature Chemical Biology 8, 26 (2012). doi:10.1038/nchembio.739 Authors: Vanessa V Phelan, Wei-Ting Liu, Kit Pogliano & Pieter C Dorrestein (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512232 Thu, 15 Dec 2011 05:00:00 +0100 5512232 Nuclear replication: Hidden iron-sulfur clusters http://www.medworm.com/index.php?rid=5512231&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FEPSq65VjqBo%2Fnchembio.737 Nature Chemical Biology 8, 24 (2012). doi:10.1038/nchembio.737 Author: Scott Bailey The multisubunit DNA polymerases of eukaryotes have iron-sulfur centers that are crucial for polymerase assembly and therefore the integrity of the nuclear genome. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512231 Thu, 15 Dec 2011 05:00:00 +0100 5512231 Metabolism: Amino acid regulatory wisdom http://www.medworm.com/index.php?rid=5512230&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F7qiFdDsG7g8%2Fnchembio.743 Authors: Tamar Avin-Wittenberg & Gad Galili Amino acids not only are useful for protein synthesis but also act as regulators of gene expression. An elegant genome-wide approach now shows how binding of amino acids to transcription factors regulates an integrated network of amino acid metabolism to suit the physiological needs of bacterial cells. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512230 Thu, 15 Dec 2011 05:00:00 +0100 5512230 Lipids: LPA activates TRPV1—and it hurts http://www.medworm.com/index.php?rid=5512229&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FTjRN8WGKFGk%2Fnchembio.738 Lipids: LPA activates TRPV1—and it hurts Nature Chemical Biology 8, 22 (2012). doi:10.1038/nchembio.738 Author: Gabor Tigyi Lysophosphatidic acid, a lipid mediator, second messenger and intermediate in lipid biosynthesis, finds a new intracellular target in TRPV1. This nonselective cation channel is also targeted by the analgesic capsaicin, which acts to desensitize the channel. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512229 Thu, 15 Dec 2011 05:00:00 +0100 5512229 Microbial ecology: When things go bad http://www.medworm.com/index.php?rid=5512228&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FeThydcYxcmY%2Fnchembio.757 Nature Chemical Biology 8, 21 (2012). doi:10.1038/nchembio.757 Author: Catherine Goodman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512228 Thu, 15 Dec 2011 05:00:00 +0100 5512228 Cancer: KEAPing NRF in check http://www.medworm.com/index.php?rid=5512227&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FrPF-MF6borU%2Fnchembio.756 Nature Chemical Biology 8, 21 (2012). doi:10.1038/nchembio.756 Author: Amy Donner (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512227 Thu, 15 Dec 2011 05:00:00 +0100 5512227 Synthetic biology: Cellular xDNA readers http://www.medworm.com/index.php?rid=5512226&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fs21oD38rs3A%2Fnchembio.755 Nature Chemical Biology 8, 21 (2012). doi:10.1038/nchembio.755 Author: Terry L. Sheppard (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512226 Thu, 15 Dec 2011 05:00:00 +0100 5512226 Drug discovery: Malaria under arrest http://www.medworm.com/index.php?rid=5512225&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FuexE5XyBFYE%2Fnchembio.754 Nature Chemical Biology 8, 21 (2012). doi:10.1038/nchembio.754 Author: Mirella Bucci (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512225 Thu, 15 Dec 2011 05:00:00 +0100 5512225 Biosynthesis: Sacrificial sulfur http://www.medworm.com/index.php?rid=5512224&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fit5fyZDLXpo%2Fnchembio.753 Nature Chemical Biology 8, 20 (2012). doi:10.1038/nchembio.753 Author: Terry L. Sheppard (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512224 Thu, 15 Dec 2011 05:00:00 +0100 5512224 Neuronal function: A Doc uses calcium http://www.medworm.com/index.php?rid=5512223&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FVeCC7kV9j1k%2Fnchembio.752 Nature Chemical Biology 8, 20 (2012). doi:10.1038/nchembio.752 Author: Mirella Bucci (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512223 Thu, 15 Dec 2011 05:00:00 +0100 5512223 Metabolism: A Warburg shakeup http://www.medworm.com/index.php?rid=5512222&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FBnYY5COJdsA%2Fnchembio.751 Nature Chemical Biology 8, 20 (2012). doi:10.1038/nchembio.751 Author: Catherine Goodman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512222 Thu, 15 Dec 2011 05:00:00 +0100 5512222 Host-microbial interactions: F-box for energy http://www.medworm.com/index.php?rid=5512221&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FMvkJBL-pRn0%2Fnchembio.750 Nature Chemical Biology 8, 20 (2012). doi:10.1038/nchembio.750 Author: Amy Donner (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512221 Thu, 15 Dec 2011 05:00:00 +0100 5512221 Bacterial outer membrane evolution via sporulation? http://www.medworm.com/index.php?rid=5512220&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FIeJpXTF8vfc%2Fnchembio.748 Nature Chemical Biology 8, 14 (2012). doi:10.1038/nchembio.748 Author: Waldemar Vollmer The distinction between different cell-envelope architectures has defined much of our thinking about bacterial systematics, but the evolution of different envelope layers has been harder to understand. A recent publication focused on the non-model organism Acetonema longum provides important clues to the possible origin of the second membrane typical of Gram-negative bacteria. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512220 Thu, 15 Dec 2011 05:00:00 +0100 5512220 Sociomicrobiology in engineered landscapes http://www.medworm.com/index.php?rid=5512219&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FhHrmBIzV4lY%2Fnchembio.749 Authors: Jodi L Connell, Marvin Whiteley & Jason B Shear A growing body of evidence points to the importance of microcolonies in the dissemination of bacteria, yet there is a dearth of tools for systematically assessing the behavior of cells within such communities. New strategies for landscaping three-dimensional culture environments on microscopic scales may have a critical role in revealing how bacteria orchestrate antibiotic resistance and other social behaviors within small, dense aggregates. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512219 Thu, 15 Dec 2011 05:00:00 +0100 5512219 Microbial environments confound antibiotic efficacy http://www.medworm.com/index.php?rid=5512218&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FzaI_20wAkHQ%2Fnchembio.740 Authors: Henry H Lee & James J Collins Despite our continued efforts to assert control over pathogens, more and more bacteria are saying “no” to drugs. It is becoming increasingly apparent that microbial environments, influenced by intracellular and extracellular metabolic processes, modulate antibiotic susceptibility in bacteria. A deeper understanding of these environmental processes may prove crucial for the development of new antibacterial therapies. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512218 Thu, 15 Dec 2011 05:00:00 +0100 5512218 What counters antibiotic resistance in nature? http://www.medworm.com/index.php?rid=5512217&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FNz_Zhg1i-vg%2Fnchembio.745 Authors: Remy Chait, Kalin Vetsigian & Roy Kishony Antibiotics promote the spread of resistance in the clinic, but various mechanisms may exist in natural environments that tilt the balance toward antibiotic sensitivity. Studying such mechanisms could help us understand the evolutionary dynamics of resistance and sensitivity in the wild, which may inspire new therapeutic strategies. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512217 Thu, 15 Dec 2011 05:00:00 +0100 5512217 Talking microbes http://www.medworm.com/index.php?rid=5512216&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FjZyTyGPhu0w%2Fnchembio.762 Nature Chemical Biology 8, 1 (2012). doi:10.1038/nchembio.762 Understanding the molecules and mechanisms that microbes use to interact with each other and their environments can lead to better antimicrobial drug design as well as a richer understanding of bacterial physiology, ecology and evolution. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512216 Thu, 15 Dec 2011 05:00:00 +0100 5512216 Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity http://www.medworm.com/index.php?rid=5512235&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FdLH8dvZB5uk%2Fnchembio.736 Authors: Candice E Paulsen, Thu H Truong, Francisco J Garcia, Arne Homann, Vinayak Gupta, Stephen E Leonard & Kate S Carroll (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512235 Sun, 11 Dec 2011 05:00:00 +0100 5512235 Unusual carbon fixation gives rise to diverse polyketide extender units http://www.medworm.com/index.php?rid=5512243&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FCEgewldFJm0%2Fnchembio.734 Authors: Nick Quade, Liujie Huo, Shwan Rachid, Dirk W Heinz & Rolf Müller (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512243 Sun, 04 Dec 2011 05:00:00 +0100 5512243 Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes http://www.medworm.com/index.php?rid=5512244&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FZjz1CACQPjs%2Fnchembio.721 Authors: Daili J A Netz, Carrie M Stith, Martin Stümpfig, Gabriele Köpf, Daniel Vogel, Heide M Genau, Joseph L Stodola, Roland Lill, Peter M J Burgers & Antonio J Pierik (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512244 Sun, 27 Nov 2011 05:00:00 +0100 5512244 Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding http://www.medworm.com/index.php?rid=5512242&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fn-tSHMi4V0E%2Fnchembio.733 Authors: Huanchen Wang, J R Falck, Traci M Tanaka Hall & Stephen B Shears (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512242 Sun, 27 Nov 2011 05:00:00 +0100 5512242 FERM domain interaction with myosin negatively regulates FAK in cardiomyocyte hypertrophy http://www.medworm.com/index.php?rid=5512241&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F9pZ0sF545jg%2Fnchembio.717 Authors: Aline M Santos, Deborah Schechtman, Alisson C Cardoso, Carolina F M Z Clemente, Júlio C Silva, Mariana Fioramonte, Michelle B M Pereira, Talita M Marin, Paulo S L Oliveira, Ana Carolina M Figueira, Saulo H P Oliveira, Íris L Torriani, Fábio C Gozzo, José Xavier Neto & Kleber G Franchini (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512241 Sun, 20 Nov 2011 05:00:00 +0100 5512241 Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils http://www.medworm.com/index.php?rid=5512240&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F15CJsBo7hhc%2Fnchembio.719 Authors: Jan Bieschke, Martin Herbst, Thomas Wiglenda, Ralf P Friedrich, Annett Boeddrich, Franziska Schiele, Daniela Kleckers, Juan Miguel Lopez del Amo, Björn A Grüning, Qinwen Wang, Michael R Schmidt, Rudi Lurz, Roger Anwyl, Sigrid Schnoegl, Marcus Fändrich, Ronald F Frank, Bernd Reif, Stefan Günther, Dominic M Walsh & Erich E W.er (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512240 Sun, 20 Nov 2011 05:00:00 +0100 5512240 Mechanical modulation of catalytic power on F1-ATPase http://www.medworm.com/index.php?rid=5512239&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fcti6Fre3wLs%2Fnchembio.715 Authors: Rikiya Watanabe, Daichi Okuno, Shouichi Sakakihara, Katsuya Shimabukuro, Ryota Iino, Masasuke Yoshida & Hiroyuki Noji (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512239 Sun, 20 Nov 2011 05:00:00 +0100 5512239 Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site http://www.medworm.com/index.php?rid=5512238&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fa3rGc--frf0%2Fnchembio.712 Authors: Andrés Nieto-Posadas, Giovanni Picazo-Juárez, Itzel Llorente, Andrés Jara-Oseguera, Sara Morales-Lázaro, Diana Escalante-Alcalde, León D Islas & Tamara Rosenbaum (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512238 Sun, 20 Nov 2011 05:00:00 +0100 5512238 Choosing an effective protein bioconjugation strategy http://www.medworm.com/index.php?rid=5417362&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FIvUkN5bJFdQ%2Fnchembio.720 Authors: Nicholas Stephanopoulos & Matthew B Francis (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417362 Tue, 15 Nov 2011 05:00:00 +0100 5417362 Lessons and revelations from biomimetic syntheses http://www.medworm.com/index.php?rid=5417361&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fgu8iXsB8aVI%2Fnchembio.709 Authors: Mina Razzak & Jef K De Brabander (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417361 Tue, 15 Nov 2011 05:00:00 +0100 5417361 Membrane trafficking: Arls squeeze the fat out http://www.medworm.com/index.php?rid=5417360&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FlF1d3cSFk7E%2Fnchembio.713 Nature Chemical Biology 7, 863 (2011). doi:10.1038/nchembio.713 Author: Roger L Williams Proteins binding to lipid moieties of GTPases can extract the GTPases from membranes. An innovative study shows that Arl2 and Arl3 act as dissociating factors that allosterically squeeze the lipid moiety of a GTPase from the grip of a lipid-binding protein, thereby facilitating reincorporation of the GTPase into membranes. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417360 Tue, 15 Nov 2011 05:00:00 +0100 5417360 Protein misfolding: Tracking a toxic polyQ epitope http://www.medworm.com/index.php?rid=5417359&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F8zI2S6TcHU4%2Fnchembio.718 Nature Chemical Biology 7, 861 (2011). doi:10.1038/nchembio.718 Author: Motomasa Tanaka The monoclonal antibody 3B5H10 that recognizes diffuse mutant huntingtin predicts cell death in primary striatal neurons. Biochemical and biophysical analyses reveal that the 3B5H10 epitope is exposed in a monomeric state, identifying this specific conformation as a toxic agent in Huntington's disease. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417359 Tue, 15 Nov 2011 05:00:00 +0100 5417359 Signaling pathways: Purinosomes under GPCR control http://www.medworm.com/index.php?rid=5417358&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F3v69cDA1uGM%2Fnchembio.716 Authors: Klaus Mohr & Evi Kostenis Cell membrane–bound G protein–coupled receptors are traditionally thought to stimulate cell proliferation by addressing the nuclear replication machinery, but we now learn that they also activate cytosolic nucleotide factories, the purinosomes. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417358 Tue, 15 Nov 2011 05:00:00 +0100 5417358 Protein structure: Charting a new course in coiled coils http://www.medworm.com/index.php?rid=5417357&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FIAJGms2SawI%2Fnchembio.714 Nature Chemical Biology 7, 859 (2011). doi:10.1038/nchembio.714 Author: Alan J Kennan Designed expansion of hydrophobic contacts converts a coiled-coil tetramer to a true hexamer, a new protein fold previously deemed unlikely to exist. The complex has a central channel sized to allow passage of water molecules. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417357 Tue, 15 Nov 2011 05:00:00 +0100 5417357 Christian R. H. Raetz 1947–2011 http://www.medworm.com/index.php?rid=5417356&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FjI4iTwMh9Yg%2Fnchembio.731 Christian R. H. Raetz 1947–2011 Nature Chemical Biology 7, 858 (2011). doi:10.1038/nchembio.731 Author: Teresa A Garrett The research community lost one of its finest members when Chris Raetz succumbed to cancer in August. Through his research and training of more than 30 students and 40 postdoctoral fellows, Chris made an indelible and lasting mark on many in the lipid biochemistry community both personally and professionally. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417356 Tue, 15 Nov 2011 05:00:00 +0100 5417356 Hormones: Molting with DHR4 http://www.medworm.com/index.php?rid=5417355&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FhgW3OdmX86Q%2Fnchembio.730 Nature Chemical Biology 7, 857 (2011). doi:10.1038/nchembio.730 Author: Amy Donner (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417355 Tue, 15 Nov 2011 05:00:00 +0100 5417355 Single-cell analysis: Bacteria tuned to FM http://www.medworm.com/index.php?rid=5417354&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FqcYEKKEsZgE%2Fnchembio.729 Nature Chemical Biology 7, 857 (2011). doi:10.1038/nchembio.729 Author: Mirella Bucci (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417354 Tue, 15 Nov 2011 05:00:00 +0100 5417354 Chemical tools: AMPing up click reactions http://www.medworm.com/index.php?rid=5417353&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F_3S1OZ_CCuY%2Fnchembio.728 Nature Chemical Biology 7, 857 (2011). doi:10.1038/nchembio.728 Author: Terry L. Sheppard (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417353 Tue, 15 Nov 2011 05:00:00 +0100 5417353 Cell division: Pulling apart peptidoglycan http://www.medworm.com/index.php?rid=5417352&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FME5CiYEb-yI%2Fnchembio.727 Nature Chemical Biology 7, 857 (2011). doi:10.1038/nchembio.727 Author: Catherine Goodman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417352 Tue, 15 Nov 2011 05:00:00 +0100 5417352 Translation: Protein polyglots http://www.medworm.com/index.php?rid=5417351&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fhc48lqongsY%2Fnchembio.726 Nature Chemical Biology 7, 856 (2011). doi:10.1038/nchembio.726 Author: Terry L. Sheppard (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417351 Tue, 15 Nov 2011 05:00:00 +0100 5417351 Biosynthesis: A dehydratase in hiding http://www.medworm.com/index.php?rid=5417350&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F9C8ngmN_ufM%2Fnchembio.725 Nature Chemical Biology 7, 856 (2011). doi:10.1038/nchembio.725 Author: Catherine Goodman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417350 Tue, 15 Nov 2011 05:00:00 +0100 5417350 Lipids: Coming together http://www.medworm.com/index.php?rid=5417349&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FEkOlsO2UyA0%2Fnchembio.724 Nature Chemical Biology 7, 856 (2011). doi:10.1038/nchembio.724 Author: Mirella Bucci (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417349 Tue, 15 Nov 2011 05:00:00 +0100 5417349 Autophagy: Deubiquitinating p53 http://www.medworm.com/index.php?rid=5417348&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FgYqK1GXIaIk%2Fnchembio.723 Nature Chemical Biology 7, 856 (2011). doi:10.1038/nchembio.723 Author: Amy Donner (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417348 Tue, 15 Nov 2011 05:00:00 +0100 5417348 Celebrating synthesis http://www.medworm.com/index.php?rid=5417347&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FpM8O6imOQMI%2Fnchembio.735 Nature Chemical Biology 7, 855 (2011). doi:10.1038/nchembio.735 Chemical synthesis plays a critical and creative role in chemical biology, providing new chemical materials to investigate biological systems. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417347 Tue, 15 Nov 2011 05:00:00 +0100 5417347 A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase http://www.medworm.com/index.php?rid=5512237&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FbTphX_k3CSA%2Fnchembio.711 Authors: Jiaoyang Jiang, Michael B Lazarus, Lincoln Pasquina, Piotr Sliz & Suzanne Walker (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512237 Sun, 13 Nov 2011 05:00:00 +0100 5512237 Deciphering the transcriptional regulatory logic of amino acid metabolism http://www.medworm.com/index.php?rid=5512236&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fmdvrqdocfqc%2Fnchembio.710 Authors: Byung-Kwan Cho, Stephen Federowicz, Young-Seoub Park, Karsten Zengler & Bernhard Ø Palsson (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5512236 Sun, 13 Nov 2011 05:00:00 +0100 5512236 Structural basis of p38α regulation by hematopoietic tyrosine phosphatase http://www.medworm.com/index.php?rid=5417369&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FQOsa3weBZkA%2Fnchembio.707 Authors: Dana M Francis, Bartosz Różycki, Dorothy Koveal, Gerhard Hummer, Rebecca Page & Wolfgang Peti (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417369 Sun, 06 Nov 2011 04:00:00 +0100 5417369 Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans http://www.medworm.com/index.php?rid=5417365&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FQFOYIOSEgB8%2Fnchembio.698 Authors: Genna M Luciani, Lilia Magomedova, Rachel Puckrin, Malene L Urbanus, Iain M Wallace, Guri Giaever, Corey Nislow, Carolyn L Cummins & Peter J Roy The DAF-9 cytochrome P450 is a key regulator of dauer formation, developmental timing and longevity in the nematode Caenorhabditis elegans. Here we describe the first identified chemical inhibitor of DAF-9 and the first reported small-molecule tool that robustly induces dauer formation in typical culture conditions. This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417365 Sun, 06 Nov 2011 04:00:00 +0100 5417365 Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes http://www.medworm.com/index.php?rid=5417373&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FiqSAXK3lWbI%2Fnchembio.693 Authors: Gregory C Patton, Pål Stenmark, Deviprasad R Gollapalli, Robin Sevastik, Petri Kursula, Susanne Flodin, Herwig Schuler, Colin T Swales, Hans Eklund, Fahmi Himo, Pär Nordlund & Lizbeth Hedstrom (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417373 Sun, 30 Oct 2011 04:00:00 +0100 5417373 A de novo peptide hexamer with a mutable channel http://www.medworm.com/index.php?rid=5417371&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F9-j0Mg1zUto%2Fnchembio.692 Authors: Nathan R Zaccai, Bertie Chi, Andrew R Thomson, Aimee L Boyle, Gail J Bartlett, Marc Bruning, Noah Linden, Richard B Sessions, Paula J Booth, R Leo Brady & Derek N Woolfson (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417371 Sun, 30 Oct 2011 04:00:00 +0100 5417371 Identifying polyglutamine protein species in situ that best predict neurodegeneration http://www.medworm.com/index.php?rid=5417370&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FpJU-P8fWqG4%2Fnchembio.694 Authors: Jason Miller, Montserrat Arrasate, Elizabeth Brooks, Clare Peters Libeu, Justin Legleiter, Danny Hatters, Jessica Curtis, Kenneth Cheung, Preethi Krishnan, Siddhartha Mitra, Kartika Widjaja, Benjamin A Shaby, Gregor P Lotz, Yvonne Newhouse, Emily J Mitchell, Alex Osmand, Michelle Gray, Vanitha Thulasiramin, Frédéric Saudou, Mark Segal, X William Yang, Eliezer Masliah, Leslie M Thompson, Paul J Muchowski, Karl H Weisgraber & Steven Finkbeiner (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417370 Sun, 30 Oct 2011 04:00:00 +0100 5417370 GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis http://www.medworm.com/index.php?rid=5417368&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FfR0ePp7ol9Q%2Fnchembio.690 Authors: Florence Verrier, Songon An, Ann M Ferrie, Haiyan Sun, Minjoung Kyoung, Huayun Deng, Ye Fang & Stephen J Benkovic (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417368 Sun, 23 Oct 2011 04:00:00 +0100 5417368 Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing http://www.medworm.com/index.php?rid=5417367&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FeTZavGaOy90%2Fnchembio.689 Authors: Ben G Small, Barry W McColl, Richard Allmendinger, Jürgen Pahle, Gloria López-Castejón, Nancy J Rothwell, Joshua Knowles, Pedro Mendes, David Brough & Douglas B Kell (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417367 Sun, 23 Oct 2011 04:00:00 +0100 5417367 A TR(i)P in the air http://www.medworm.com/index.php?rid=5330392&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fljkd7Ioy-kk%2Fnchembio1111-853 Nature Chemical Biology 7, 853 (2011). doi:10.1038/nchembio1111-853 Author: Peter Zygmunt (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330392 Tue, 18 Oct 2011 04:00:00 +0100 5330392 Plant biology: Blocking galactolipid biosynthesis http://www.medworm.com/index.php?rid=5330379&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FqU3TON__0Eo%2Fnchembio.691 Nature Chemical Biology 7, 761 (2011). doi:10.1038/nchembio.691 Author: Kent D Chapman The first selective inhibitor of monogalactosyldiacylglycerol (MGDG) synthase was identified from a chemical library screen. The competitive inhibitor effectively targets MGDG concentrations across plant tissues and was used to demonstrate a new role for galactolipids in pollen-tube development. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330379 Tue, 18 Oct 2011 04:00:00 +0100 5330379 Ion channels: Manipulating the munchies in mice http://www.medworm.com/index.php?rid=5330378&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FArMvzAcHcTs%2Fnchembio.697 Nature Chemical Biology 7, 759 (2011). doi:10.1038/nchembio.697 Author: Myles H Akabas Crystal structure and drug pharmacophore structure-activity data guided a combined mutagenesis and chemical screen to develop ligand-gated ion channels activated by unique chemical agonists. Through genetic engineering, these channels can be used to manipulate neuronal excitability and dissect the neuronal circuitry responsible for complex behaviors. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330378 Tue, 18 Oct 2011 04:00:00 +0100 5330378 Carbohydrates: Cracking the glycan sequence code http://www.medworm.com/index.php?rid=5330377&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FQ6CFs1qHfcE%2Fnchembio.696 Authors: Christopher J Jones & Cynthia K Larive For years scientists have debated whether glycans, like DNA, RNA and proteins, have a true sequence. In a recent study, researchers show that the proteoglycan bikunin has a defined and predictable sequence, opening the door for a new understanding of the glycome. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330377 Tue, 18 Oct 2011 04:00:00 +0100 5330377 Protein folding: Gamers see the solution http://www.medworm.com/index.php?rid=5330376&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FL-gLCUyx0ws%2Fnchembio.706 Nature Chemical Biology 7, 757 (2011). doi:10.1038/nchembio.706 Author: Catherine Goodman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330376 Tue, 18 Oct 2011 04:00:00 +0100 5330376 Biosynthesis: Finding pheofungins http://www.medworm.com/index.php?rid=5330375&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FEvQ8HW8ir08%2Fnchembio.705 Nature Chemical Biology 7, 757 (2011). doi:10.1038/nchembio.705 Author: Terry L. Sheppard (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330375 Tue, 18 Oct 2011 04:00:00 +0100 5330375 Olfaction: A DEET-induced confusion http://www.medworm.com/index.php?rid=5330374&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F7FoFXQI1HAE%2Fnchembio.704 Nature Chemical Biology 7, 757 (2011). doi:10.1038/nchembio.704 Author: Mirella Bucci (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330374 Tue, 18 Oct 2011 04:00:00 +0100 5330374 Channels: GRASPing CFTR http://www.medworm.com/index.php?rid=5330373&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FrEvgPGf7pcc%2Fnchembio.703 Nature Chemical Biology 7, 757 (2011). doi:10.1038/nchembio.703 Author: Amy Donner (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330373 Tue, 18 Oct 2011 04:00:00 +0100 5330373 Malaria: An addiction to isoprenoids http://www.medworm.com/index.php?rid=5330372&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FeoToAbP6Bgg%2Fnchembio.702 Nature Chemical Biology 7, 756 (2011). doi:10.1038/nchembio.702 Author: Mirella Bucci (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330372 Tue, 18 Oct 2011 04:00:00 +0100 5330372 Drug discovery: Sidelining c-Myc http://www.medworm.com/index.php?rid=5330371&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fud8XblUPRto%2Fnchembio.701 Nature Chemical Biology 7, 756 (2011). doi:10.1038/nchembio.701 Author: Terry L. Sheppard (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330371 Tue, 18 Oct 2011 04:00:00 +0100 5330371 Metalloenzymes: Copper chews on cellulose http://www.medworm.com/index.php?rid=5330370&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FQ-Ch1EK1tTA%2Fnchembio.700 Nature Chemical Biology 7, 756 (2011). doi:10.1038/nchembio.700 Author: Catherine Goodman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330370 Tue, 18 Oct 2011 04:00:00 +0100 5330370 Stem cells: Oxidative renewal http://www.medworm.com/index.php?rid=5330369&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FVyDwnLQRGAM%2Fnchembio.699 Nature Chemical Biology 7, 756 (2011). doi:10.1038/nchembio.699 Author: Amy Donner (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330369 Tue, 18 Oct 2011 04:00:00 +0100 5330369 Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo http://www.medworm.com/index.php?rid=5417372&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fv_-y-0u57QQ%2Fnchembio.686 Authors: Shehab A Ismail, Yong-Xiang Chen, Alexandra Rusinova, Anchal Chandra, Martin Bierbaum, Lothar Gremer, Gemma Triola, Herbert Waldmann, Philippe I H Bastiaens & Alfred Wittinghofer (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417372 Sun, 16 Oct 2011 04:00:00 +0100 5417372 α-ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition http://www.medworm.com/index.php?rid=5417366&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fu5nQ3HmIHac%2Fnchembio.685 Authors: Christopher D Doucette, David J Schwab, Ned S Wingreen & Joshua D Rabinowitz (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417366 Sun, 16 Oct 2011 04:00:00 +0100 5417366 N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO http://www.medworm.com/index.php?rid=5417363&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FCWOL0piU8hQ%2Fnchembio.687 We report here that fat mass and obesity-associated protein (FTO) has efficient oxidative demethylation activity targeting the abundant N6-methyladenosine (m6A) residues in RNA in vitro. FTO knockdown with siRNA led to increased amounts of m6A in mRNA, whereas overexpression of FTO resulted in decreased amounts of m6A in human cells. We further show the partial colocalization of FTO with nuclear speckles, which supports the notion that m6A in nuclear RNA is a major physiological substrate of FTO. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417363 Sun, 16 Oct 2011 04:00:00 +0100 5417363 Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation http://www.medworm.com/index.php?rid=5330391&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FUyDQDDSHuOU%2Fnchembio.671 Authors: Je Won Park, Sung Ryeol Park, Keshav Kumar Nepal, Ah Reum Han, Yeon Hee Ban, Young Ji Yoo, Eun Ji Kim, Eui Min Kim, Dooil Kim, Jae Kyung Sohng & Yeo Joon Yoon (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330391 Sun, 09 Oct 2011 04:00:00 +0100 5330391 The proteoglycan bikunin has a defined sequence http://www.medworm.com/index.php?rid=5330389&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FAyOdC4H_zVk%2Fnchembio.673 Authors: Mellisa Ly, Franklin E Leach, Tatiana N Laremore, Toshihiko Toida, I Jonathan Amster & Robert J Linhardt (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330389 Sun, 09 Oct 2011 04:00:00 +0100 5330389 A mass spectrometry–guided genome mining approach for natural product peptidogenomics http://www.medworm.com/index.php?rid=5330385&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FZfuZLL9mdsA%2Fnchembio.684 Authors: Roland D Kersten, Yu-Liang Yang, Yuquan Xu, Peter Cimermancic, Sang-Jip Nam, William Fenical, Michael A Fischbach, Bradley S Moore & Pieter C Dorrestein (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330385 Sun, 09 Oct 2011 04:00:00 +0100 5330385 Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4 http://www.medworm.com/index.php?rid=5330381&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FltOsfxvTLkw%2Fnchembio.667 Structural basis for cytokinin recognition by Arabidopsis thaliana histidine kinase 4 Nature Chemical Biology 7, 766 (2011). doi:10.1038/nchembio.667 Authors: Michael Hothorn, Tsegaye Dabi & Joanne Chory Cytokinins are classic hormones that orchestrate plant growth and development and the integrity of stem cell populations. Cytokinin receptors are eukaryotic sensor histidine kinases that are activated by both naturally occurring adenine-type cytokinins and urea-based synthetic compounds. Crystal structures of the Arabidopsis thalianahistidine kinase 4 sensor domain in complex with different cytokinin ligands now rationalize the hormone-binding specificity of the receptor and may spur the design of new cytokinin ligands. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330381 Sun, 02 Oct 2011 04:00:00 +0100 5330381 Chemical inhibitors of monogalactosyldiacylglycerol synthases in Arabidopsis thaliana http://www.medworm.com/index.php?rid=5330390&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FxdV0KT1ARZY%2Fnchembio.658 Authors: Cyrille Y Botté, Michael Deligny, Aymeric Roccia, Anne-Laure Bonneau, Nadia Saïdani, Hélène Hardré, Samia Aci, Yoshiki Yamaryo-Botté, Juliette Jouhet, Emmanuelle Dubots, Karen Loizeau, Olivier Bastien, Laurent Bréhélin, Jacques Joyard, Jean-Christophe Cintrat, Denis Falconet, Maryse A Block, Bernard Rousseau, Roman Lopez & Eric Maréchal (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330390 Sun, 25 Sep 2011 04:00:00 +0100 5330390 Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90 http://www.medworm.com/index.php?rid=5330388&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FRjMvRazxh3A%2Fnchembio.670 Authors: Kamalika Moulick, James H Ahn, Hongliang Zong, Anna Rodina, Leandro Cerchietti, Erica M Gomes DaGama, Eloisi Caldas-Lopes, Kristin Beebe, Fabiana Perna, Katerina Hatzi, Ly P Vu, Xinyang Zhao, Danuta Zatorska, Tony Taldone, Peter Smith-Jones, Mary Alpaugh, Steven S Gross, Nagavarakishore Pillarsetty, Thomas Ku, Jason S Lewis, Steven M Larson, Ross Levine, Hediye Erdjument-Bromage, Monica L Guzman, Stephen D Nimer, Ari Melnick, Len Neckers & Gabriela Chiosis (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330388 Sun, 25 Sep 2011 04:00:00 +0100 5330388 On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds http://www.medworm.com/index.php?rid=5330387&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FzmCEejQ83nY%2Fnchembio.664 Authors: Tina R White, Chad M Renzelman, Arthur C Rand, Taha Rezai, Cayla M McEwen, Vladimir M Gelev, Rushia A Turner, Roger G Linington, Siegfried S F Leung, Amit S Kalgutkar, Jonathan N Bauman, Yizhong Zhang, Spiros Liras, David A Price, Alan M Mathiowetz, Matthew P Jacobson & R Scott Lokey (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330387 Sun, 25 Sep 2011 04:00:00 +0100 5330387 (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2 http://www.medworm.com/index.php?rid=5330386&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FV6F9guj7iBA%2Fnchembio.663 Authors: Kelsey C Duggan, Daniel J Hermanson, Joel Musee, Jeffery J Prusakiewicz, Jami L Scheib, Bruce D Carter, Surajit Banerjee, J A Oates & Lawrence J Marnett (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330386 Sun, 25 Sep 2011 04:00:00 +0100 5330386 A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer http://www.medworm.com/index.php?rid=5330384&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F2cxD39_P0AY%2Fnchembio.695 Authors: Markus K Muellner, Iris Z Uras, Bianca V Gapp, Claudia Kerzendorfer, Michal Smida, Hannelore Lechtermann, Nils Craig-Mueller, Jacques Colinge, Gerhard Duernberger & Sebastian M B Nijman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330384 Sun, 25 Sep 2011 04:00:00 +0100 5330384 Plant chemical biology: Florigen takes two to tango http://www.medworm.com/index.php?rid=5233245&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F5U9RJJ6bb_w%2Fnchembio.666 Authors: Joshua S Mylne & Philip A Wigge A recent flurry of activity has defined the protein FLOWERING LOCUS T (FT) as a mobile signal or 'florigen' that induces flowering. A new study has shown that a 14-3-3 protein links FT to a transcription factor at the plant apex to initiate flowering. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233245 Mon, 19 Sep 2011 04:00:00 +0100 5233245 Channels: A TR(i)P in the air http://www.medworm.com/index.php?rid=5233243&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F_wxOqF-cHjs%2Fnchembio.669 Nature Chemical Biology 7, 661 (2011). doi:10.1038/nchembio.669 Author: Peter M Zygmunt Monitoring oxygen (O2) levels is essential to optimizing aerobic metabolism and ensuring proper biological processes in most eukaryotes. The spice chemosensor TRPA1 is a previously unidentified O2 sensor in the mammalian sensory nervous system that warns against hyperoxia and hypoxia. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233243 Mon, 19 Sep 2011 04:00:00 +0100 5233243 RNA structure: Riboswitch strikes a chord http://www.medworm.com/index.php?rid=5233242&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FjoM6CIxi6dc%2Fnchembio.672 Nature Chemical Biology 7, 660 (2011). doi:10.1038/nchembio.672 Author: Charles E Dann Purine riboswitches have served as models for riboswitch structure, dynamics, evolution and engineering. New crystallographic models reveal the adaptability of a purine riboswitch evolved to bind 2′-deoxyguanosine and highlight challenges inherent to riboswitch engineering. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233242 Mon, 19 Sep 2011 04:00:00 +0100 5233242 Glycobiology: Challenging reaction equilibria http://www.medworm.com/index.php?rid=5233241&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fk1Eg4ulN9Eo%2Fnchembio.668 Nature Chemical Biology 7, 658 (2011). doi:10.1038/nchembio.668 Author: Robert A Field The glycosyltransferase-catalyzed generation of sugar nucleotides is normally an unfavorable endothermic process. Simple reactive glycosides used in conjunction with mutant transferases enable such reactions to become favorable exothermic processes, providing practical access to a diverse range of non-natural sugar nucleotides. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233241 Mon, 19 Sep 2011 04:00:00 +0100 5233241 Receptors: GPCR–G protein preassembly? http://www.medworm.com/index.php?rid=5233240&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fp1fjyYJp26E%2Fnchembio.665 Receptors: GPCR–G protein preassembly? Nature Chemical Biology 7, 657 (2011). doi:10.1038/nchembio.665 Authors: R A John Challiss & Jürgen Wess The extent to which ligand-free GPCRs exist in quasi-stable 'precoupled' complexes with G proteins in vivo is uncertain. New research, using fluorescence recovery after photobleaching (FRAP), reveals a structural requirement for and functional consequences of muscarinic acetylcholine receptor–Gq protein preassembly. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233240 Mon, 19 Sep 2011 04:00:00 +0100 5233240 Developmental biology: Diffusing with Sog http://www.medworm.com/index.php?rid=5233239&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F-GD8MhwXAWQ%2Fnchembio.681 Nature Chemical Biology 7, 655 (2011). doi:10.1038/nchembio.681 Author: Amy Donner (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233239 Mon, 19 Sep 2011 04:00:00 +0100 5233239 Microbiology: Using gas as a raft http://www.medworm.com/index.php?rid=5233238&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FTWrrW_-tqXo%2Fnchembio.680 Nature Chemical Biology 7, 655 (2011). doi:10.1038/nchembio.680 Author: Mirella Bucci (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233238 Mon, 19 Sep 2011 04:00:00 +0100 5233238 Metabolic engineering: Strike that, reverse it http://www.medworm.com/index.php?rid=5233237&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FYJRnd0OTaDA%2Fnchembio.679 Nature Chemical Biology 7, 655 (2011). doi:10.1038/nchembio.679 Author: Catherine Goodman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233237 Mon, 19 Sep 2011 04:00:00 +0100 5233237 Imaging: Green fluorescent RNA http://www.medworm.com/index.php?rid=5233236&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F7urCyfPzo3k%2Fnchembio.678 Nature Chemical Biology 7, 655 (2011). doi:10.1038/nchembio.678 Author: Terry L Sheppard (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233236 Mon, 19 Sep 2011 04:00:00 +0100 5233236 Signaling: Clathrin pitstops http://www.medworm.com/index.php?rid=5233235&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FXIb0JjL-ibo%2Fnchembio.677 Nature Chemical Biology 7, 654 (2011). doi:10.1038/nchembio.677 Author: Amy Donner (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233235 Mon, 19 Sep 2011 04:00:00 +0100 5233235 Neuroscience: How to fill a vesicle http://www.medworm.com/index.php?rid=5233234&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FtF1CUHSYF6Y%2Fnchembio.676 Nature Chemical Biology 7, 654 (2011). doi:10.1038/nchembio.676 Author: Mirella Bucci (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233234 Mon, 19 Sep 2011 04:00:00 +0100 5233234 Translation: Recoding worms http://www.medworm.com/index.php?rid=5233233&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FVsr0PYyHOTw%2Fnchembio.675 Nature Chemical Biology 7, 654 (2011). doi:10.1038/nchembio.675 Author: Terry L Sheppard (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233233 Mon, 19 Sep 2011 04:00:00 +0100 5233233 Antibiotics: One-atom activity http://www.medworm.com/index.php?rid=5233232&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FYu9D29hc2eo%2Fnchembio.674 Nature Chemical Biology 7, 654 (2011). doi:10.1038/nchembio.674 Author: Catherine Goodman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233232 Mon, 19 Sep 2011 04:00:00 +0100 5233232 SAS-6 oligomerization: the key to the centriole? http://www.medworm.com/index.php?rid=5233231&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FV0BeIONsGgE%2Fnchembio.660 Authors: Matthew A Cottee, Jordan W Raff, Susan M Lea & Hélio Roque Centrioles are among the most beautiful of biological structures. How their highly conserved nine-fold symmetry is generated is a question that has intrigued cell biologists for decades. Two recent structural studies provide the tantalizing suggestion that the self-organizing properties of the SAS-6 protein hold the answer. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233231 Mon, 19 Sep 2011 04:00:00 +0100 5233231 Our professional opinion http://www.medworm.com/index.php?rid=5233230&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FV6F9guj7iBA%2Fnchembio.663 Nature Chemical Biology 7, 649 (2011). doi:10.1038/nchembio.663 Professional editors provide the perspective, consistency and responsiveness needed to identify and communicate groundbreaking scientific advances. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233230 Mon, 19 Sep 2011 04:00:00 +0100 5233230 A natural prodrug activation mechanism in nonribosomal peptide synthesis http://www.medworm.com/index.php?rid=5417364&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FAMUks7CHq5k%2Fnchembio.688 Authors: Daniela Reimer, Klaas M Pos, Marco Thines, Peter Grün & Helge B Bode (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5417364 Sun, 18 Sep 2011 04:00:00 +0100 5417364 RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites http://www.medworm.com/index.php?rid=5330383&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FOAkRuUHnfgE%2Fnchembio.657 Authors: David B F Johnson, Jianfeng Xu, Zhouxin Shen, Jeffrey K Takimoto, Matthew D Schultz, Robert J Schmitz, Zheng Xiang, Joseph R Ecker, Steven P Briggs & Lei Wang (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330383 Sun, 18 Sep 2011 04:00:00 +0100 5330383 Ligand discovery from a dopamine D3 receptor homology model and crystal structure http://www.medworm.com/index.php?rid=5330382&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F4UFjfsi935c%2Fnchembio.662 Authors: Jens Carlsson, Ryan G Coleman, Vincent Setola, John J Irwin, Hao Fan, Avner Schlessinger, Andrej Sali, Bryan L Roth & Brian K Shoichet (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330382 Sun, 18 Sep 2011 04:00:00 +0100 5330382 Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids http://www.medworm.com/index.php?rid=5330380&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fj8kWax1mpyw%2Fnchembio.659 Authors: Jonathan Z Long, Justin S Cisar, David Milliken, Sherry Niessen, Chu Wang, Sunia A Trauger, Gary Siuzdak & Benjamin F Cravatt All organisms, including humans, possess a huge number of uncharacterized enzymes. Here we describe a general cell-based screen for enzyme substrate discovery by untargeted metabolomics and its application to identify the protein α/β-hydrolase domain–containing 3 (ABHD3) as a lipase that selectively cleaves medium-chain and oxidatively truncated phospholipids. Abhd3−/− mice possess elevated myristoyl (C14)-phospholipids, including the bioactive lipid C14-lysophosphatidylcholine, confirming the physiological relevance of our substrate assignments. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5330380 Sun, 18 Sep 2011 04:00:00 +0100 5330380 Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor http://www.medworm.com/index.php?rid=5233252&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FvIqT8kuqwsg%2Fnchembio.645 Authors: Miguel A Mata, Neal Satterly, Gijs A Versteeg, Doug Frantz, Shuguang Wei, Noelle Williams, Mirco Schmolke, Samuel Peña-Llopis, James Brugarolas, Christian V Forst, Michael A White, Adolfo García-Sastre, Michael G Roth & Beatriz M A Fontoura (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233252 Sun, 11 Sep 2011 04:00:00 +0100 5233252 High-frequency transposition for determining antibacterial mode of action http://www.medworm.com/index.php?rid=5233253&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FOn8r_NQ2HJw%2Fnchembio.643 Authors: Hao Wang, David Claveau, John P Vaillancourt, Terry Roemer & Timothy C Meredith (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233253 Sun, 04 Sep 2011 04:00:00 +0100 5233253 A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance http://www.medworm.com/index.php?rid=5233247&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FoTJUrLYagTQ%2Fnchembio.644 Authors: Meng Zhang, Shixian Lin, Xinwen Song, Jun Liu, Ye Fu, Xi Ge, Xinmiao Fu, Zengyi Chang & Peng R Chen (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233247 Sun, 04 Sep 2011 04:00:00 +0100 5233247 Inactive-state preassembly of Gq-coupled receptors and Gq heterotrimers http://www.medworm.com/index.php?rid=5233255&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FJxPKCu37s3o%2Fnchembio.642 Authors: Kou Qin, Chunmin Dong, Guangyu Wu & Nevin A Lambert (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233255 Sun, 28 Aug 2011 04:00:00 +0100 5233255 Ligand binding to distinct states diverts aggregation of an amyloid-forming protein http://www.medworm.com/index.php?rid=5233254&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FNaELSSRRl5g%2Fnchembio.635 Authors: Lucy A Woods, Geoffrey W Platt, Andrew L Hellewell, Eric W Hewitt, Steve W Homans, Alison E Ashcroft & Sheena E Radford (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233254 Sun, 28 Aug 2011 04:00:00 +0100 5233254 TRPA1 underlies a sensing mechanism for O2 http://www.medworm.com/index.php?rid=5233251&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FC_Z1BeNOXAc%2Fnchembio.640 Authors: Nobuaki Takahashi, Tomoyuki Kuwaki, Shigeki Kiyonaka, Tomohiro Numata, Daisuke Kozai, Yusuke Mizuno, Shinichiro Yamamoto, Shinji Naito, Ellen Knevels, Peter Carmeliet, Toru Oga, Shuji Kaneko, Seiji Suga, Toshiki Nokami, Jun-ichi Yoshida & Yasuo Mori (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233251 Sun, 28 Aug 2011 04:00:00 +0100 5233251 Epigenetics: Targeting leukemia on the DOT http://www.medworm.com/index.php?rid=5233244&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2F3AtwYhonvRw%2Fnchembio.661 Authors: Jon Travers, Julian Blagg & Paul Workman A combination of chemical and genetic approaches has established a proof of concept in mouse models—with strong mechanistic underpinning—indicating that targeting the aberrantly recruited histone methyltransferase activity of DOT1L has therapeutic potential in aggressive leukemias driven by MLL fusion genes. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233244 Sun, 28 Aug 2011 04:00:00 +0100 5233244 Multiple ligand-specific conformations of the β2-adrenergic receptor http://www.medworm.com/index.php?rid=5233250&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FR1f-IzwB5Dg%2Fnchembio.634 Authors: Alem W Kahsai, Kunhong Xiao, Sudarshan Rajagopal, Seungkirl Ahn, Arun K Shukla, Jinpeng Sun, Terrence G Oas & Robert J Lefkowitz (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233250 Sun, 21 Aug 2011 04:00:00 +0100 5233250 Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions http://www.medworm.com/index.php?rid=5233249&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FS7RCJzcQZTY%2Fnchembio.638 Authors: Richard W Gantt, Pauline Peltier-Pain, William J Cournoyer & Jon S Thorson (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233249 Sun, 21 Aug 2011 04:00:00 +0100 5233249 Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism http://www.medworm.com/index.php?rid=5233248&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FFjP-P1d26oU%2Fnchembio.633 Authors: Anja Lehwess-Litzmann, Piotr Neumann, Christoph Parthier, Stefan Lüdtke, Ralph Golbik, Ralf Ficner & Kai Tittmann (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233248 Sun, 21 Aug 2011 04:00:00 +0100 5233248 Behind the folding funnel diagram http://www.medworm.com/index.php?rid=5155474&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FigCZDVI5cg4%2Fnchembio0911-648d Nature Chemical Biology 7, 648 (2011). doi:10.1038/nchembio0911-648d Author: Martin Karplus (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155474 Tue, 16 Aug 2011 23:00:00 +0100 5155474 A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells http://www.medworm.com/index.php?rid=5155473&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FknHF_-YfWuo%2Fnchembio0911-648c Nature Chemical Biology 7, 648 (2011). doi:10.1038/nchembio0911-648c Author: Masoud Vedadi, Dalia Barsyte-Lovejoy, Feng Liu, Sylvie Rival-Gervier, Abdellah Allali-Hassani, Viviane Labrie, Tim J Wigle, Peter A DiMaggio, Gregory A Wasney, Alena Siarheyeva, Aiping Dong, Wolfram Tempel, Sun-Chong Wang, Xin Chen, Irene Chau, Thomas J Mangano, Xi-ping Huang, Catherine D Simpson, Samantha G Pattenden, Jacqueline L Norris, Dmitri B Kireev, Ashutosh Tripathy, Aled Edwards, Bryan L Roth, William P Janzen, Benjamin A Garcia, Arturas Petronis, James Ellis, Peter J Brown, Stephen V Frye, Cheryl H Arrowsmith & Jian Jin (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155473 Tue, 16 Aug 2011 23:00:00 +0100 5155473 A unique iron-sulfur cluster is crucial for oxygen tolerance of a [NiFe]-hydrogenase http://www.medworm.com/index.php?rid=5155472&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FS-MuCXCIw_0%2Fnchembio0911-648b Nature Chemical Biology 7, 648 (2011). doi:10.1038/nchembio0911-648b Author: Tobias Goris, Annemarie F Wait, Miguel Saggu, Johannes Fritsch, Nina Heidary, Matthias Stein, Ingo Zebger, Friedhelm Lendzian, Fraser A Armstrong, Bärbel Friedrich & Oliver Lenz (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155472 Tue, 16 Aug 2011 23:00:00 +0100 5155472 Reaction design: Nature-inspired total synthesis http://www.medworm.com/index.php?rid=5155460&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fr7mW_Iu8O74%2Fnchembio.637 Authors: Laura Furst & Corey R J Stephenson Nature's approach to biosynthesis often involves the rapid generation of advanced, enantiopure intermediates from simple starting materials. A new, highly efficient strategy adapts this approach, using organocascade catalysis to quickly construct a key intermediate that can be converted into several complex natural products. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155460 Tue, 16 Aug 2011 23:00:00 +0100 5155460 Amyloidogenesis: FlAsH illuminates Aβ aggregation http://www.medworm.com/index.php?rid=5155459&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fj_BCegIWc44%2Fnchembio.636 Amyloidogenesis: FlAsH illuminates Aβ aggregation Nature Chemical Biology 7, 581 (2011). doi:10.1038/nchembio.636 Author: Tiago F Outeiro Protein misfolding, oligomerization and aggregation are implicated in a variety of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. New research sheds light on the process of amyloid-β aggregation in vitro, identifying nucleated conformational conversion of oligomers as the mechanism for generating amyloid fibrils. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155459 Tue, 16 Aug 2011 23:00:00 +0100 5155459 Biomaterials: Redox and adhesion on the rocks http://www.medworm.com/index.php?rid=5155458&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fx7XidQ7AIJ0%2Fnchembio.639 Nature Chemical Biology 7, 579 (2011). doi:10.1038/nchembio.639 Author: Jonathan J Wilker Man-made adhesives cannot match the ability of a marine mussel to affix itself to a wet rock. New insights help to describe the protein-surface bonding central to this feat of biological materials engineering. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155458 Tue, 16 Aug 2011 23:00:00 +0100 5155458 GPCRs: Caught in a spectroscopic trap http://www.medworm.com/index.php?rid=5155457&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FB1WNagkEmE8%2Fnchembio.641 Nature Chemical Biology 7, 578 (2011). doi:10.1038/nchembio.641 Author: Jacob Piehler Homo- and heterodimerization of G protein–coupled receptors (GPCRs) have been described for numerous receptors, but their functional role has remained elusive. With a new spectroscopic assay based on protein fragment complementation, GPCR heterodimerization was demonstrated to contribute to a phenomenon called 'functional selectivity'. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155457 Tue, 16 Aug 2011 23:00:00 +0100 5155457 Lipidomics: A viral egress http://www.medworm.com/index.php?rid=5155456&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FhNY1qXijc5I%2Fnchembio.654 Nature Chemical Biology 7, 577 (2011). doi:10.1038/nchembio.654 Author: Mirella Bucci (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155456 Tue, 16 Aug 2011 23:00:00 +0100 5155456 Signaling: Hijacking a GTPase http://www.medworm.com/index.php?rid=5155455&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fa_alaNp-q10%2Fnchembio.653 Nature Chemical Biology 7, 577 (2011). doi:10.1038/nchembio.653 Author: Amy Donner (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155455 Tue, 16 Aug 2011 23:00:00 +0100 5155455 Cancer therapeutics: Fomenting radical behavior http://www.medworm.com/index.php?rid=5155454&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FPFDDoXMN948%2Fnchembio.652 Nature Chemical Biology 7, 577 (2011). doi:10.1038/nchembio.652 Author: Terry L Sheppard (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155454 Tue, 16 Aug 2011 23:00:00 +0100 5155454 Enzyme mechanisms: A cope-ing strategy http://www.medworm.com/index.php?rid=5155453&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FKQWC-5gnPqM%2Fnchembio.651 Nature Chemical Biology 7, 577 (2011). doi:10.1038/nchembio.651 Author: Catherine Goodman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155453 Tue, 16 Aug 2011 23:00:00 +0100 5155453 Protein-protein interactions: GRBing dynamic networks http://www.medworm.com/index.php?rid=5155452&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FM1Tlh6WpO7c%2Fnchembio.650 Nature Chemical Biology 7, 576 (2011). doi:10.1038/nchembio.650 Author: Amy Donner (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155452 Tue, 16 Aug 2011 23:00:00 +0100 5155452 DNA demethylation: TDG links in http://www.medworm.com/index.php?rid=5155451&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FvIwKRF_yX8g%2Fnchembio.648 Nature Chemical Biology 7, 576 (2011). doi:10.1038/nchembio.648 Author: Terry L Sheppard (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155451 Tue, 16 Aug 2011 23:00:00 +0100 5155451 Metabolic engineering: A plastic pathway http://www.medworm.com/index.php?rid=5155450&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FZVYatne0bh8%2Fnchembio.647 Nature Chemical Biology 7, 576 (2011). doi:10.1038/nchembio.647 Author: Catherine Goodman (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155450 Tue, 16 Aug 2011 23:00:00 +0100 5155450 Electrophysiology: Blinking bacteria http://www.medworm.com/index.php?rid=5155449&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FwfUN5QZcSos%2Fnchembio.646 Nature Chemical Biology 7, 576 (2011). doi:10.1038/nchembio.646 Author: Mirella Bucci (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155449 Tue, 16 Aug 2011 23:00:00 +0100 5155449 Made to measure http://www.medworm.com/index.php?rid=5155448&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FGH0BYOc-XS4%2Fnchembio.656 Nature Chemical Biology 7, 575 (2011). doi:10.1038/nchembio.656 Defining the scope and venue of a scientific paper requires a balance between the authors' goals for the study and reasonable feedback gleaned through peer review. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155448 Tue, 16 Aug 2011 23:00:00 +0100 5155448 Structural principles of nucleoside selectivity in a 2′-deoxyguanosine riboswitch http://www.medworm.com/index.php?rid=5233256&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FUnAtNmwDxdY%2Fnchembio.631 Authors: Olga Pikovskaya, Anna Polonskaia, Dinshaw J Patel & Alexander Serganov (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233256 Sun, 14 Aug 2011 04:00:00 +0100 5233256 The tRNA synthetase paralog PoxA modifies elongation factor-P with (R)-β-lysine http://www.medworm.com/index.php?rid=5233246&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2Fn72YlVaxQac%2Fnchembio.632 Authors: Hervé Roy, S Betty Zou, Tammy J Bullwinkle, Benjamin S Wolfe, Marla S Gilreath, Craig J Forsyth, William W Navarre & Michael Ibba The lysyl-tRNA synthetase paralog PoxA modifies elongation factor P (EF-P) with α-lysine at low efficiency. Cell-free extracts containing non–α-lysine substrates of PoxA modified EF-P with a change in mass consistent with addition of β-lysine, a substrate also predicted by genomic analyses. EF-P was efficiently functionally modified with (R)-β-lysine but not (S)-β-lysine or genetically encoded α-amino acids, indicating that PoxA has evolved an activity orthogonal to that of the canonical aminoacyl-tRNA synthetases. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5233246 Sun, 14 Aug 2011 04:00:00 +0100 5233246 Natural products reveal cancer cell dependence on oxysterol-binding proteins http://www.medworm.com/index.php?rid=5155470&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FLz0Pw_Up36E%2Fnchembio.625 Authors: Anthony W G Burgett, Thomas B Poulsen, Kittikhun Wangkanont, D Ryan Anderson, Chikako Kikuchi, Kousei Shimada, Shuichi Okubo, Kevin C Fortner, Yoshihiro Mimaki, Minpei Kuroda, Jason P Murphy, David J Schwalb, Eugene C Petrella, Ivan Cornella-Taracido, Markus Schirle, John A Tallarico & Matthew D Shair (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155470 Sat, 06 Aug 2011 23:00:00 +0100 5155470 Mechanistic evidence for a front-side, SNi-type reaction in a retaining glycosyltransferase http://www.medworm.com/index.php?rid=5155469&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FqZvP9IT54Wg%2Fnchembio.628 Authors: Seung Seo Lee, Sung You Hong, James C Errey, Atsushi Izumi, Gideon J Davies & Benjamin G Davis (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155469 Sat, 06 Aug 2011 23:00:00 +0100 5155469 Amyloid-β forms fibrils by nucleated conformational conversion of oligomers http://www.medworm.com/index.php?rid=5155465&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FZZ3zfaQ8gO4%2Fnchembio.624 Authors: Jiyong Lee, Elizabeth K Culyba, Evan T Powers & Jeffery W Kelly (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155465 Sat, 30 Jul 2011 23:00:00 +0100 5155465 Mussel protein adhesion depends on interprotein thiol-mediated redox modulation http://www.medworm.com/index.php?rid=5155462&cid=s_32088_62_f&fid=32088&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnchembio%2Frss%2Fcurrent%2F%7E3%2FPienUI5L05k%2Fnchembio.630 Authors: Jing Yu, Wei Wei, Eric Danner, Rebekah K Ashley, Jacob N Israelachvili & J Herbert Waite Mussel adhesion is mediated by foot proteins (mfps) rich in a catecholic amino acid, 3,4-dihydroxyphenylalanine (dopa), capable of forming strong bidentate interactions with a variety of surfaces. A tendency toward facile auto-oxidation, however, often renders dopa unreliable for adhesion. We demonstrate that mussels limit dopa oxidation during adhesive plaque formation by imposing an acidic, reducing regime based on the thiol-rich mfp-6, which restores dopa by coupling the oxidation of thiols to dopaquinone reduction. (Source: Nature Chemical Biology) Nature Chemical Biology journals http://www.medworm.com/rss/comments.php?id=5155462 Sat, 30 Jul 2011 23:00:00 +0100 5155462