MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nature Medicine' source. Wed, 08 Feb 2012 18:50:30 +0100 http://www.medworm.com/index.php?rid=5668443&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FsLlr10_-4Y8%2Fnm.2651 In this study we report the presence of loss-of-function mutations and deletions of the EZH2 and SUZ12 genes, which encode crucial components of the Polycomb repressive complex 2 (PRC2), in 25% of T-ALLs. To further study the role of PRC2 in T-ALL, we used NOTCH1-dependent mouse models of the disease, as well as human T-ALL samples, and combined locus-specific and global analysis of NOTCH1-driven epigenetic changes. These studies demonstrated that activation of NOTCH1 specifically induces loss of the repressive mark Lys27 trimethylation of histone 3 (H3K27me3) by antagonizing the activity of PRC2. These studies suggest a tumor suppressor role for PRC2 in human leukemia and suggest a hitherto unrecognized dynamic interplay between oncogenic NOTCH1 and PRC2 function for the regulation of gen... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668443 Mon, 06 Feb 2012 05:00:00 +0100 5668443 http://www.medworm.com/index.php?rid=5668430&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fnp_utQpFinU%2Fnm.2572 Authors: Tom J Little, Judith E Allen, Simon A Babayan, Keith R Matthews & Nick Colegrave Pathogens have remarkable abilities to flout therapeutic intervention. This characteristic is driven by evolution, either as a direct response to intervention (for example, the evolution of antibiotic resistance) or through long-term co-evolution that generates host or parasite traits that interact with therapy in undesirable or unpredicted ways. To make progress towards successful control of infectious diseases, the concepts and techniques of evolutionary biology must be deeply integrated with traditional approaches to immunology and pathogen biology. An interdisciplinary approach can inform our strategies to control pathogens or even the treatment of infected patients, positioning us to meet the... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668430 Mon, 06 Feb 2012 05:00:00 +0100 5668430 http://www.medworm.com/index.php?rid=5668429&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FeQWz1Z_CpSw%2Fnm.2677 Nature Medicine 18, 215 (2012). doi:10.1038/nm.2677 Author: Carolina Pola (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668429 Mon, 06 Feb 2012 05:00:00 +0100 5668429 http://www.medworm.com/index.php?rid=5668428&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FBaqhHL6rtF4%2Fnm.2676 Nature Medicine 18, 215 (2012). doi:10.1038/nm.2676 Author: Kevin Da Silva (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668428 Mon, 06 Feb 2012 05:00:00 +0100 5668428 http://www.medworm.com/index.php?rid=5668427&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FqA4G-tmI6wE%2Fnm.2675 Nature Medicine 18, 215 (2012). doi:10.1038/nm.2675 Author: Meera Swami (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668427 Mon, 06 Feb 2012 05:00:00 +0100 5668427 http://www.medworm.com/index.php?rid=5668426&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FtljNfLblhZA%2Fnm.2674 Nature Medicine 18, 215 (2012). doi:10.1038/nm.2674 Author: Randy Levinson (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668426 Mon, 06 Feb 2012 05:00:00 +0100 5668426 http://www.medworm.com/index.php?rid=5668425&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FYSn_qCRtH6I%2Fnm.2671 Authors: Heike Tost & Andreas Meyer-Lindenberg (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668425 Mon, 06 Feb 2012 05:00:00 +0100 5668425 http://www.medworm.com/index.php?rid=5668424&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FvTelrS27Avo%2Fnm.2670 Nature Medicine 18, 210 (2012). doi:10.1038/nm.2670 Author: Patrick F Sullivan Effective treatment for schizophrenia is still an unmet clinical need. Alleviating problems associated with cognitive impairment and finding the root of the disease remain priorities for clinicians and scientists. The incomplete understanding of the basis of this pathology has urged for research that will unravel the genetic origin of schizophrenia. But studies involving environmental exposure and social impact have also hinted at extrinsic factors as players in the pathogenesis of schizophrenia, which may be exploited to prevent the development of the disease. In 'Bench to Bedside', Patrick Sullivan proposes a model putting forward how genetic variants may confer risk by functioning together within th... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668424 Mon, 06 Feb 2012 05:00:00 +0100 5668424 http://www.medworm.com/index.php?rid=5668423&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FNelzGjjUTzY%2Fnm0212-208 Nature Medicine 18, 208 (2012). doi:10.1038/nm0212-208 (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668423 Mon, 06 Feb 2012 05:00:00 +0100 5668423 http://www.medworm.com/index.php?rid=5668422&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FW3Fm85f8RfE%2Fnm.2647 Authors: Wanda Layman & Jian Zuo Noise-induced hearing loss is caused primarily by damage to auditory hair cells; however, humans are unable to regenerate damaged hair cells, necessitating the development of new therapeutic strategies to protect auditory hair cells. A new study suggests that the use of phosphodiesterase 5 (PDE5) inhibitors may provide a protective therapeutic route for hearing loss (pages 252–259). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668422 Mon, 06 Feb 2012 05:00:00 +0100 5668422 http://www.medworm.com/index.php?rid=5668421&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F3z9Ga-INS-A%2Fnm.2655 Authors: Xi Wang & Charles W M Roberts A newly identified role for SMAD specific E3 ubiquitin protein ligase 2 (Smurf2) in the regulation of histone ubiquitination uncovers a broad tumor suppressor activity that helps to maintain genomic stability in mice. A recent study suggests a new mechanism underlying the role of ubiquitination in cancer (pages 227–234). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668421 Mon, 06 Feb 2012 05:00:00 +0100 5668421 http://www.medworm.com/index.php?rid=5668420&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FdWJCu_hqpQ4%2Fnm.2630 Nature Medicine 18, 202 (2012). doi:10.1038/nm.2630 Author: Clifford J Rosen New strategies for selectively stimulating bone formation without promoting bone resorption are required, as all currently approved agents for osteoporosis act on both of these aspects of the bone remodeling process. A recent study describes an approach that specifically delivers therapeutic siRNAs to bone-forming surfaces without affecting bone resorption (pages 307–314). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668420 Mon, 06 Feb 2012 05:00:00 +0100 5668420 http://www.medworm.com/index.php?rid=5668419&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fv6-BIoBt73o%2Fnm.2654 Nature Medicine 18, 200 (2012). doi:10.1038/nm.2654 Author: Anne Kelso Why do some influenza infections cause fatal disease and others barely a sniffle? Although viral virulence can vary, the immunological history of the host is also important. A new study in humans suggests that CD4+ T lymphocytes activated during previous infections can limit disease severity in the absence of specific antibodies (pages 274–280). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668419 Mon, 06 Feb 2012 05:00:00 +0100 5668419 http://www.medworm.com/index.php?rid=5668418&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FWHUCNiTjAp0%2Fnm.2646 Authors: Alberto Bardelli & Pasi A Jänne Some individuals with colorectal cancer benefit from therapies targeting the epidermal growth factor receptor (EGFR). However, resistance to EGFR blockade inevitably occurs. The characterization of a new mechanism of resistance to the EGFR-specific antibody cetuximab provides clues into how therapeutic strategies might be designed to overcome this specific resistance mechanism (pages 221–223). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668418 Mon, 06 Feb 2012 05:00:00 +0100 5668418 http://www.medworm.com/index.php?rid=5668417&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FfLuzlqRc-lc%2Fnm.2668 Authors: Jeannette N Stankowski, Valina L Dawson & Ted M Dawson A new study shows that mice lacking tau develop parkinsonism because of intracellular iron accumulation that results in degeneration of dopamine neurons. Tau deficiency seems to impair ferroportin iron export by retention of the amyloid precursor protein, a neuronal ferroxidase partner, inside the endoplasmic reticulum (pages 291–295). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668417 Mon, 06 Feb 2012 05:00:00 +0100 5668417 http://www.medworm.com/index.php?rid=5668416&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FOVS-ZZE33Uc%2Fnm.2662 Nature Medicine 18, 195 (2012). doi:10.1038/nm.2662 Author: Amy E. Slaton (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668416 Mon, 06 Feb 2012 05:00:00 +0100 5668416 http://www.medworm.com/index.php?rid=5668415&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FNxejBZslS_I%2Fnm0212-194 Authors: Garth M Funston & Adam M H Young The long-term decline in the number of UK doctors who conduct research is well recognized. Although some signs of recovery have been noted in the last few years, government budget cuts and the imminent rise in the tuition fee cap may make a bad situation worse. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668415 Mon, 06 Feb 2012 05:00:00 +0100 5668415 http://www.medworm.com/index.php?rid=5668414&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F3Zch30Tg_y0%2Fnm0212-190 Nature Medicine 18, 190 (2012). doi:10.1038/nm0212-190 Author: Elie Dolgin Suicide is the third leading cause of death in the US among people under the age of 45. Yet psychiatrists know remarkably little about what treatments can most effectively prevent people from killing themselves. For the most part, investigators have shied away from studying the problem head-on because designing intervention studies with suicidal subjects is fraught with difficulty. Elie Dolgin talks to the small group of mental health professionals who are hoping to put an end to that. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668414 Mon, 06 Feb 2012 05:00:00 +0100 5668414 http://www.medworm.com/index.php?rid=5668413&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FuBVBFyXMmfk%2Fnm0212-189 Nature Medicine 18, 189 (2012). doi:10.1038/nm0212-189 (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668413 Mon, 06 Feb 2012 05:00:00 +0100 5668413 http://www.medworm.com/index.php?rid=5668412&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FjeECICRmhNo%2Fnm0212-188 Nature Medicine 18, 188 (2012). doi:10.1038/nm0212-188 (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668412 Mon, 06 Feb 2012 05:00:00 +0100 5668412 http://www.medworm.com/index.php?rid=5668411&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FqGB_1BsA4pY%2Fnm0212-187 Nature Medicine 18, 187 (2012). doi:10.1038/nm0212-187 Author: Amber Dance (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668411 Mon, 06 Feb 2012 05:00:00 +0100 5668411 http://www.medworm.com/index.php?rid=5668410&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fsc1ceDo-LoY%2Fnm0212-186b Nature Medicine 18, 186 (2012). doi:10.1038/nm0212-186b Author: Rebecca Hersher (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668410 Mon, 06 Feb 2012 05:00:00 +0100 5668410 http://www.medworm.com/index.php?rid=5668409&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Frq5iPfyxpPA%2Fnm0212-186a Nature Medicine 18, 186 (2012). doi:10.1038/nm0212-186a Author: Rebecca Hersher (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668409 Mon, 06 Feb 2012 05:00:00 +0100 5668409 http://www.medworm.com/index.php?rid=5668408&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F80EWbD_EU7c%2Fnm0212-185 Nature Medicine 18, 185 (2012). doi:10.1038/nm0212-185 Author: Rebecca Hersher (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668408 Mon, 06 Feb 2012 05:00:00 +0100 5668408 http://www.medworm.com/index.php?rid=5668407&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F1CaOOUIGsyA%2Fnm0212-184b Nature Medicine 18, 184 (2012). doi:10.1038/nm0212-184b Author: Melinda Wenner Moyer (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668407 Mon, 06 Feb 2012 05:00:00 +0100 5668407 http://www.medworm.com/index.php?rid=5668406&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FmpiPEmMdrj8%2Fnm0212-184a Nature Medicine 18, 184 (2012). doi:10.1038/nm0212-184a Author: Michele Catanzaro (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668406 Mon, 06 Feb 2012 05:00:00 +0100 5668406 http://www.medworm.com/index.php?rid=5668405&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F0hht7AkZWFU%2Fnm0212-183 Nature Medicine 18, 183 (2012). doi:10.1038/nm0212-183 Author: Elie Dolgin (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668405 Mon, 06 Feb 2012 05:00:00 +0100 5668405 http://www.medworm.com/index.php?rid=5668404&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FpzKJArEPBM4%2Fnm0212-182 Nature Medicine 18, 182 (2012). doi:10.1038/nm0212-182 Author: Killugudi Jayaraman (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668404 Mon, 06 Feb 2012 05:00:00 +0100 5668404 http://www.medworm.com/index.php?rid=5668403&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FirNtb2foFvc%2Fnm0212-181 Nature Medicine 18, 181 (2012). doi:10.1038/nm0212-181 Author: Roxanne Palmer (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668403 Mon, 06 Feb 2012 05:00:00 +0100 5668403 http://www.medworm.com/index.php?rid=5668402&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F1dV0Y23uWVw%2Fnm.2672 Nature Medicine 18, 179 (2012). doi:10.1038/nm.2672 Budget cuts and administrative changes that have eliminated the Ministry of Science in Spain illustrate the need to safeguard science funding and policies in European countries immersed in the economic crisis. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668402 Mon, 06 Feb 2012 05:00:00 +0100 5668402 http://www.medworm.com/index.php?rid=5668445&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fa0tH4c8QThI%2Fnm.2617 Authors: Ge Zhang, Baosheng Guo, Heng Wu, Tao Tang, Bao-Ting Zhang, Lizhen Zheng, Yixin He, Zhijun Yang, Xiaohua Pan, Heelum Chow, Kinwah To, Yaping Li, Dahu Li, Xinluan Wang, Yixiang Wang, Kwongman Lee, Zhibo Hou, Nan Dong, Gang Li, Kwoksui Leung, Leungkim Hung, Fuchu He, Lingqiang Zhang & Ling Qin (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668445 Sun, 29 Jan 2012 05:00:00 +0100 5668445 http://www.medworm.com/index.php?rid=5668442&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FLT195hkjs8A%2Fnm.2613 Authors: Peng Lei, Scott Ayton, David I Finkelstein, Loredana Spoerri, Giuseppe D Ciccotosto, David K Wright, Bruce X W Wong, Paul A Adlard, Robert A Cherny, Linh Q Lam, Blaine R Roberts, Irene Volitakis, Gary F Egan, Catriona A McLean, Roberto Cappai, James A Duce & Ashley I Bush The microtubule-associated protein tau has risk alleles for both Alzheimer's disease and Parkinson's disease and mutations that cause brain degenerative diseases termed tauopathies. Aggregated tau forms neurofibrillary tangles in these pathologies, but little is certain about the function of tau or its mode of involvement in pathogenesis. Neuronal iron accumulation has been observed pathologically in the cortex in Alzheimer's disease, the substantia nigra (SN) in Parkinson's disease and various brain regions ... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668442 Sun, 29 Jan 2012 05:00:00 +0100 5668442 http://www.medworm.com/index.php?rid=5668439&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FkX36xk4cy5Y%2Fnm.2612 Authors: Tom M Wilkinson, Chris K F Li, Cecilia S C Chui, Arthur K Y Huang, Molly Perkins, Julia C Liebner, Rob Lambkin-Williams, Anthony Gilbert, John Oxford, Ben Nicholas, Karl J Staples, Tao Dong, Daniel C Douek, Andrew J McMichael & Xiao-Ning Xu (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668439 Sun, 29 Jan 2012 05:00:00 +0100 5668439 http://www.medworm.com/index.php?rid=5668438&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FDpTLIk32TeM%2Fnm.2584 MicroRNA-21 targets the vitamin D–dependent antimicrobial pathway in leprosy Nature Medicine 18, 267 (2012). doi:10.1038/nm.2584 Authors: Philip T Liu, Matthew Wheelwright, Rosane Teles, Evangelia Komisopoulou, Kristina Edfeldt, Benjamin Ferguson, Manali D Mehta, Aria Vazirnia, Thomas H Rea, Euzenir N Sarno, Thomas G Graeber & Robert L Modlin (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668438 Sun, 29 Jan 2012 05:00:00 +0100 5668438 http://www.medworm.com/index.php?rid=5668444&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FyVHphfaxLN4%2Fnm.2615 Authors: Kejia Cai, Mohammad Haris, Anup Singh, Feliks Kogan, Joel H Greenberg, Hari Hariharan, John A Detre & Ravinder Reddy (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668444 Sun, 22 Jan 2012 05:00:00 +0100 5668444 http://www.medworm.com/index.php?rid=5668436&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F_TIEehGJGao%2Fnm.2634 Authors: Mirko Jaumann, Juliane Dettling, Martin Gubelt, Ulrike Zimmermann, Andrea Gerling, François Paquet-Durand, Susanne Feil, Stephan Wolpert, Christoph Franz, Ksenya Varakina, Hao Xiong, Niels Brandt, Stephanie Kuhn, Hyun-Soon Geisler, Karin Rohbock, Peter Ruth, Jens Schlossmann, Joachim Hütter, Peter Sandner, Robert Feil, Jutta Engel, Marlies Knipper & Lukas Rüttiger (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668436 Sun, 22 Jan 2012 05:00:00 +0100 5668436 http://www.medworm.com/index.php?rid=5668432&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FgWr43PXQ1Mk%2Fnm.2608 Authors: Dianren Xia, Dingzhi Wang, Sun-Hee Kim, Hiroshi Katoh & Raymond N DuBois Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E2 (PGE2) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE2 in the promotion of tumor progression. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668432 Sun, 22 Jan 2012 05:00:00 +0100 5668432 http://www.medworm.com/index.php?rid=5668431&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FR7Dxv3p9SHM%2Fnm.2609 We describe an acquired EGFR ectodomain mutation (S492R) that prevents cetuximab binding and confers resistance to cetuximab. Cells with this mutation, however, retain binding to and are growth inhibited by panitumumab. Two of ten subjects studied here with disease progression after cetuximab treatment acquired this mutation. A subject with cetuximab resistance harboring the S492R mutation responded to treatment with panitumumab. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668431 Sun, 22 Jan 2012 05:00:00 +0100 5668431 http://www.medworm.com/index.php?rid=5668446&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F-xP-h4kew5s%2Fnm.2616 Authors: Elizabeth L Bird-Lieberman, André A Neves, Pierre Lao-Sirieix, Maria O'Donovan, Marco Novelli, Laurence B Lovat, William S Eng, Lara K Mahal, Kevin M Brindle & Rebecca C Fitzgerald (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668446 Sun, 15 Jan 2012 05:00:00 +0100 5668446 http://www.medworm.com/index.php?rid=5668441&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Frhk0FsljU10%2Fnm.2603 Authors: Oleksandra Prysyazhna, Olena Rudyk & Philip Eaton Blood pressure regulation is crucial for the maintenance of health, and hypertension is a risk factor for myocardial infarction, heart failure, stroke and renal disease. Nitric oxide (NO) and prostacyclin trigger well-defined vasodilator pathways; however, substantial vasorelaxation in response to agents such as acetylcholine persists when the synthesis of these molecules is prevented. This remaining vasorelaxation activity, termed endothelium-derived hyperpolarizing factor (EDHF), is more prevalent in resistance than in conduit blood vessels and is considered a major mechanism for blood pressure control. Hydrogen peroxide (H2O2) has been shown to be a major component of EDHF in several vascular beds in multiple species, includ... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668441 Sun, 15 Jan 2012 05:00:00 +0100 5668441 http://www.medworm.com/index.php?rid=5668437&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FUxw-rCoI3iU%2Fnm.2628 Authors: Fei Chen, Zhugong Liu, Wenhui Wu, Cristina Rozo, Scott Bowdridge, Ariel Millman, Nico Van Rooijen, Joseph F Urban, Thomas A Wynn & William C Gause (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668437 Sun, 15 Jan 2012 05:00:00 +0100 5668437 http://www.medworm.com/index.php?rid=5668434&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FYyuszgzIU0w%2Fnm.2614 Authors: Wenshan Wang, Na Lv, Shasha Zhang, Guanghou Shui, Hui Qian, Jingfeng Zhang, Yuanying Chen, Jing Ye, Yuansheng Xie, Yuemao Shen, Markus R Wenk & Peng Li (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668434 Sun, 15 Jan 2012 05:00:00 +0100 5668434 http://www.medworm.com/index.php?rid=5668440&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FriU4p2vTiQU%2Fnm.2581 Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor Nature Medicine 18, 281 (2012). doi:10.1038/nm.2581 Authors: Bruno Sainz, Naina Barretto, Danyelle N Martin, Nobuhiko Hiraga, Michio Imamura, Snawar Hussain, Katherine A Marsh, Xuemei Yu, Kazuaki Chayama, Waddah A Alrefai & Susan L Uprichard Hepatitis C virus (HCV) is a leading cause of liver disease worldwide. With ∼170 million individuals infected and current interferon-based treatment having toxic side effects and marginal efficacy, more effective antivirals are crucially needed. Although HCV protease inhibitors were just approved by the US Food and Drug Administration (FDA), optimal HCV therapy, analogous to HIV therapy, will probably require a c... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668440 Sun, 08 Jan 2012 05:00:00 +0100 5668440 http://www.medworm.com/index.php?rid=5668435&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F7OoD0eQKE4Q%2Fnm.2598 Authors: Johanna T Lanner, Dimitra K Georgiou, Adan Dagnino-Acosta, Alina Ainbinder, Qing Cheng, Aditya D Joshi, Zanwen Chen, Viktor Yarotskyy, Joshua M Oakes, Chang Seok Lee, Tanner O Monroe, Arturo Santillan, Keke Dong, Laurie Goodyear, Iskander I Ismailov, George G Rodney, Robert T Dirksen & Susan L Hamilton (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668435 Sun, 08 Jan 2012 05:00:00 +0100 5668435 http://www.medworm.com/index.php?rid=5668433&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FWJFTeysR_yo%2Fnm.2596 Authors: Michael Blank, Yi Tang, Motozo Yamashita, Sandra S Burkett, Steven Y Cheng & Ying E Zhang (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5668433 Sun, 08 Jan 2012 05:00:00 +0100 5668433 http://www.medworm.com/index.php?rid=5583839&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FgWnBdNmvvBI%2Fnm.2635 Authors: Hartmut Wekerle, Alexander Flügel, Lars Fugger, Georg Schett & David Serreze Animal models are indispensable for studying disease pathogenesis and discovering new treatments for human organ-specific autoimmune diseases. However, there is a need of more refined paradigms for these models. Ideally, a small-animal model should represent the clinical features of human disease in their entirety. Disease in the animals should develop spontaneously, should be followed over an extended period of time and should involve the genetic, molecular and cellular elements that contribute to human pathogenesis. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583839 Fri, 06 Jan 2012 05:00:00 +0100 5583839 http://www.medworm.com/index.php?rid=5583838&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FDtqRr0d1LnE%2Fnm.2625 Authors: Lawrence Steinman, Joan T Merrill, Iain B McInnes & Mark Peakman There are multiple immune-based therapeutics available for some of the most prevalent autoimmune diseases, but for others, there are few or no approved immune therapies. This dichotomy poses discrete challenges. First, for diseases in which multiple therapy choices exist, a rational decision tree is required to select the best therapy. Second, we must devise new strategies for the autoimmune diseases that have the highest unmet clinical need. This commentary outlines new strategies for designing more efficient and selective approaches for immune therapy of autoimmune diseases. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583838 Fri, 06 Jan 2012 05:00:00 +0100 5583838 http://www.medworm.com/index.php?rid=5583837&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FeWlSvFIOmpY%2Fnm.2622 Authors: Shimon Sakaguchi, Fiona Powrie & Richard M Ransohoff Recent progress has revealed the molecular basis of how self-reactive T cells are normally generated in the immune system and differentiate into autoimmune effector T cells and how they are controlled by central and peripheral mechanisms of self-tolerance. There is also evidence that target tissues and cells in autoimmune disease have different sensitivities to immune mediators. Here we describe how these basic findings can be clinically translated to re-establish self-tolerance in individuals with autoimmune disease. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583837 Fri, 06 Jan 2012 05:00:00 +0100 5583837 http://www.medworm.com/index.php?rid=5583836&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FPeMwQUGpUUA%2Fnm.2626 Authors: Bart O Roep, Jane Buckner, Stephen Sawcer, Rene Toes & Frauke Zipp Translational research in autoimmunity is hampered by a number of hurdles, including a lack of knowledge regarding initiating and pathologically relevant autoantigens, the low frequency of autoreactive pathogenic B and T cells, difficulty in accessing the affected tissue, differences between self-reactive and pathogen-specific lymphocytes, a lack of etiologically relevant preclinical animal models and the heterogeneity of disease presentation. Given the need for biomarkers and new therapeutics, it is imperative that these hurdles be surmounted. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583836 Fri, 06 Jan 2012 05:00:00 +0100 5583836 http://www.medworm.com/index.php?rid=5583835&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fh2lb3mZmZeo%2Fnm.2621 Authors: Vijay K Kuchroo, Pamela S Ohashi, R Balfour Sartor & Carola G Vinuesa Great strides have been made in our understanding of the pathogenesis of autoimmune diseases. Research has identified genetic associations, new functional subsets of effector and regulatory T cells and the gut microbiota as crucial environmental factors in regulating immune function. This commentary discusses recent advances in our understanding of genetic and environmental factors as well as the role of innate and adaptive immune responses in driving immune-mediated tissue injury. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583835 Fri, 06 Jan 2012 05:00:00 +0100 5583835 http://www.medworm.com/index.php?rid=5583834&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FEEFZglIofJ4%2Fnm.2632 Authors: Richard S Blumberg, Bonnie Dittel, David Hafler, Matthias von Herrath & Frank O Nestle Autoimmune diseases have a complex etiology and despite great progress having been made in our comprehension of these disorders, there has been limited success in the development of approved medications based on these insights. Development of drugs and strategies for application in translational research and medicine are hampered by an inadequate molecular definition of the human autoimmune phenotype and the organizational models that are necessary to clarify this definition. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583834 Fri, 06 Jan 2012 05:00:00 +0100 5583834 http://www.medworm.com/index.php?rid=5583833&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fhu29ND7GSxY%2Fnm.2642 Nature Medicine 18, 34 (2012). doi:10.1038/nm.2642 Author: Kevin Da Silva (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583833 Fri, 06 Jan 2012 05:00:00 +0100 5583833 http://www.medworm.com/index.php?rid=5583832&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FEVpyFu1vnXc%2Fnm.2641 Nature Medicine 18, 34 (2012). doi:10.1038/nm.2641 Author: Randy Levinson (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583832 Fri, 06 Jan 2012 05:00:00 +0100 5583832 http://www.medworm.com/index.php?rid=5583831&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FvAwXza-3CTI%2Fnm.2640 Nature Medicine 18, 34 (2012). doi:10.1038/nm.2640 Author: Meera Swami (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583831 Fri, 06 Jan 2012 05:00:00 +0100 5583831 http://www.medworm.com/index.php?rid=5583830&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FSECbl3luHMA%2Fnm.2639 Nature Medicine 18, 34 (2012). doi:10.1038/nm.2639 Author: Eva Chmielnicki (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583830 Fri, 06 Jan 2012 05:00:00 +0100 5583830 http://www.medworm.com/index.php?rid=5583829&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FhFfZjIz-BYk%2Fnm.2637 Nature Medicine 18, 32 (2012). doi:10.1038/nm.2637 Author: Patrick H Maxwell (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583829 Fri, 06 Jan 2012 05:00:00 +0100 5583829 http://www.medworm.com/index.php?rid=5583828&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fik1M5kmSYNc%2Fnm.2631 Nature Medicine 18, 30 (2012). doi:10.1038/nm.2631 Author: Michael Ohh Cancer cells thrive owing to different means of survival and proliferation. But despite growing understanding of the biology of cancer and the mechanism of tumorigenesis, complete knowledge of what causes cancer is still lacking. There are multiple hypotheses as to what drives cells to become malignant. One of them is the Warburg effect, which supports that an increase in glycolysis over oxidative respiration, even in the presence of oxygen, may be the cause of cancer. But this premise has not yet been confirmed. In 'Bench to Bedside', Michael Ohh peruses a recent study showing a common mutation in people with renal cell carcinoma and melanoma that may rekindle the debate as to whether a metabolic switch is a ... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583828 Fri, 06 Jan 2012 05:00:00 +0100 5583828 http://www.medworm.com/index.php?rid=5583827&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fiu1uKwB0yXM%2Fnm0112-28 Nature Medicine 18, 28 (2012). doi:10.1038/nm0112-28 (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583827 Fri, 06 Jan 2012 05:00:00 +0100 5583827 http://www.medworm.com/index.php?rid=5583826&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FdPCRM1r-EI0%2Fnm.2602 Authors: Sumant S Chugh & Lionel C Clement Collapsing glomerulopathy, the classic kidney lesion in HIV-associated nephropathy, is characterized by the closure of glomerular capillary loops and epithelial cell proliferation. A new study shows that upregulation of TERT, the reverse transcriptase component of telomerase, in podocytes, the key filtration cells in the kidney, plays a major part in the development of this condition by activating Wnt signaling (pages 111–119). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583826 Fri, 06 Jan 2012 05:00:00 +0100 5583826 http://www.medworm.com/index.php?rid=5583825&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FEzCa02MlEfU%2Fnm.2624 Nature Medicine 18, 24 (2012). doi:10.1038/nm.2624 Author: Albert R La Spada The search for compounds to treat neurodegenerative disorders is especially pressing given the rapidly growing elderly human population and has led to the consideration of sirtuin proteins as potential therapeutic candidates. Two studies now report that modulating the expression of the sirtuin Sirt1 has therapeutic benefit in Huntington's disease mouse models and identify putative downstream targets of Sirt1 involved in improved disease outcomes (pages 159–165 and 153–158). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583825 Fri, 06 Jan 2012 05:00:00 +0100 5583825 http://www.medworm.com/index.php?rid=5583824&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FaOXQpC3YREc%2Fnm.2623 Authors: Lisa M McGinnis & Calvin J Kuo A new study in mice shows that platelet-derived growth factor-B (PDGF-B) boosts tumor growth by exerting a double function after induction of erythropoietin (EPO) expression from stromal components—a proangiogeneic response in the endothelium and hematopoietic stimulation (pages 100–110). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583824 Fri, 06 Jan 2012 05:00:00 +0100 5583824 http://www.medworm.com/index.php?rid=5583823&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F-D-PoFX-59M%2Fnm.2636 Nature Medicine 18, 21 (2012). doi:10.1038/nm.2636 Author: Calman A MacLennan The beneficial cytoprotective effects of heme oxygenase-1 (HO-1) in malaria infection are counterpoised by higher susceptibility to nontyphoidal Salmonella (NTS) bacteremia. A new study in mice co-infected with malaria and Salmonella provides a mechanism for the long-recognized association between malaria and NTS infection in African children. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583823 Fri, 06 Jan 2012 05:00:00 +0100 5583823 http://www.medworm.com/index.php?rid=5583822&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F5DZpLUKbe7s%2Fnm.2638 Nature Medicine 18, 19 (2012). doi:10.1038/nm.2638 Author: Lisa Sanders (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583822 Fri, 06 Jan 2012 05:00:00 +0100 5583822 http://www.medworm.com/index.php?rid=5583821&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FKg2WFR1NzRA%2Fnm0112-17 Nature Medicine 18, 17 (2012). doi:10.1038/nm0112-17 Author: Shawn Lawrence Otto In the US, science has increasingly taken a backstage to politics in policy decisions. But as the country enters the presidential primary season this month, one of the most counterintuitive but effective ways for researchers to make a difference may be to join the GOP. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583821 Fri, 06 Jan 2012 05:00:00 +0100 5583821 http://www.medworm.com/index.php?rid=5583820&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F9oxKFI3xvR0%2Fnm0112-12 Nature Medicine 18, 12 (2012). doi:10.1038/nm0112-12 Author: Elie Dolgin Each year, around 100,000 people worldwide receive solid organ transplants, and from the day of their surgery to the day they die almost all of them have to take daily immunosuppressant drugs to prevent the body from attacking the new organ. But an experimental procedure in which patients receive some of the donor's bone marrow in addition to the organ hopes to eliminate the need for lifelong drug therapy. Elie Dolgin talks to the scientists who are rejecting the idea of transplantation as usual. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583820 Fri, 06 Jan 2012 05:00:00 +0100 5583820 http://www.medworm.com/index.php?rid=5583819&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F_MfZePzicJU%2Fnm0112-10 Nature Medicine 18, 10 (2012). doi:10.1038/nm0112-10 (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583819 Fri, 06 Jan 2012 05:00:00 +0100 5583819 http://www.medworm.com/index.php?rid=5583818&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FvR7ZXQv22eM%2Fnm0112-9 Nature Medicine 18, 9 (2012). doi:10.1038/nm0112-9 Author: Rebecca Hersher (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583818 Fri, 06 Jan 2012 05:00:00 +0100 5583818 http://www.medworm.com/index.php?rid=5583817&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FPUDDqVNvfmQ%2Fnm0112-8b Nature Medicine 18, 8 (2012). doi:10.1038/nm0112-8b Author: Hannah Waters (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583817 Fri, 06 Jan 2012 05:00:00 +0100 5583817 http://www.medworm.com/index.php?rid=5583816&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FRstaOp7FpCo%2Fnm0112-8a Nature Medicine 18, 8 (2012). doi:10.1038/nm0112-8a Author: Cassandra Willyard (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583816 Fri, 06 Jan 2012 05:00:00 +0100 5583816 http://www.medworm.com/index.php?rid=5583815&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FBddBkiAgDp0%2Fnm0112-7b Nature Medicine 18, 7 (2012). doi:10.1038/nm0112-7b (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583815 Fri, 06 Jan 2012 05:00:00 +0100 5583815 http://www.medworm.com/index.php?rid=5583814&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FUK9fEX0goLo%2Fnm0112-7a Nature Medicine 18, 7 (2012). doi:10.1038/nm0112-7a Author: Asher Mullard (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583814 Fri, 06 Jan 2012 05:00:00 +0100 5583814 http://www.medworm.com/index.php?rid=5583813&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FlW7y2SfGnps%2Fnm0112-6 Nature Medicine 18, 6 (2012). doi:10.1038/nm0112-6 Author: Rebecca Hersher (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583813 Fri, 06 Jan 2012 05:00:00 +0100 5583813 http://www.medworm.com/index.php?rid=5583812&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FIJSBUFQ7as0%2Fnm0112-5 Nature Medicine 18, 5 (2012). doi:10.1038/nm0112-5 Author: Sarah C P Williams (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583812 Fri, 06 Jan 2012 05:00:00 +0100 5583812 http://www.medworm.com/index.php?rid=5583811&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F2pfVGYl6G0k%2Fnm0112-4b Nature Medicine 18, 4 (2012). doi:10.1038/nm0112-4b Author: Hannah Waters (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583811 Fri, 06 Jan 2012 05:00:00 +0100 5583811 http://www.medworm.com/index.php?rid=5583810&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FMhBCoJFlygQ%2Fnm0112-4a Nature Medicine 18, 4 (2012). doi:10.1038/nm0112-4a Author: Madhumita Venkataramanan (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583810 Fri, 06 Jan 2012 05:00:00 +0100 5583810 http://www.medworm.com/index.php?rid=5583809&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FBDuu1iE7VHw%2Fnm0112-3 Nature Medicine 18, 3 (2012). doi:10.1038/nm0112-3 Author: Madhumita Venkataramanan (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583809 Fri, 06 Jan 2012 05:00:00 +0100 5583809 http://www.medworm.com/index.php?rid=5583808&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FmW3k92AVUYs%2Fnm.2643 Nature Medicine 18, 1 (2012). doi:10.1038/nm.2643 Emergency contraceptive pills have long been a hot button issue in US politics due to their mischaracterization as inducing abortion and promoting promiscuity, leading to delayed approvals and restricted access. A recent decision on the Plan B One-Step pill suggests that, once again, science has taken a back seat to politics. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583808 Fri, 06 Jan 2012 05:00:00 +0100 5583808 http://www.medworm.com/index.php?rid=5583853&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FyUIG5sE1vP0%2Fnm.2600 Authors: Ali Ertürk, Christoph P Mauch, Farida Hellal, Friedrich Förstner, Tara Keck, Klaus Becker, Nina Jährling, Heinz Steffens, Melanie Richter, Mark Hübener, Edgar Kramer, Frank Kirchhoff, Hans Ulrich Dodt & Frank Bradke (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583853 Sun, 25 Dec 2011 05:00:00 +0100 5583853 http://www.medworm.com/index.php?rid=5583849&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FCemsWoa0NbU%2Fnm.2582 Authors: Netta Sela-Passwell, Raghavendra Kikkeri, Orly Dym, Haim Rozenberg, Raanan Margalit, Rina Arad-Yellin, Miriam Eisenstein, Ori Brenner, Tsipi Shoham, Tamar Danon, Abraham Shanzer & Irit Sagi Endogenous tissue inhibitors of metalloproteinases (TIMPs) have key roles in regulating physiological and pathological cellular processes. Imitating the inhibitory molecular mechanisms of TIMPs while increasing selectivity has been a challenging but desired approach for antibody-based therapy. TIMPs use hybrid protein-protein interactions to form an energetic bond with the catalytic metal ion, as well as with enzyme surface residues. We used an innovative immunization strategy that exploits aspects of molecular mimicry to produce inhibitory antibodies that show TIMP-like binding mechanisms ... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583849 Sun, 25 Dec 2011 05:00:00 +0100 5583849 http://www.medworm.com/index.php?rid=5583852&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fx0Q4My7yXIc%2Fnm.2559 Authors: Hyunkyung Jeong, Dena E Cohen, Libin Cui, Andrea Supinski, Jeffrey N Savas, Joseph R Mazzulli, John R Yates, Laura Bordone, Leonard Guarente & Dimitri Krainc Sirt1, a NAD-dependent protein deacetylase, has emerged as a key regulator of mammalian transcription in response to cellular metabolic status and stress. Here we show that Sirt1 has a neuroprotective role in models of Huntington's disease, an inherited neurodegenerative disorder caused by a glutamine repeat expansion in huntingtin protein (HTT). Brain-specific knockout of Sirt1 results in exacerbation of brain pathology in a mouse model of Huntington's disease, whereas overexpression of Sirt1 improves survival, neuropathology and the expression of brain-derived neurotrophic factor (BDNF) in Huntington's disease mice. We ... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583852 Sun, 18 Dec 2011 05:00:00 +0100 5583852 http://www.medworm.com/index.php?rid=5583851&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fw-ZBO8CGBDo%2Fnm.2558 Authors: Mali Jiang, Jiawei Wang, Jinrong Fu, Lin Du, Hyunkyung Jeong, Tim West, Lan Xiang, Qi Peng, Zhipeng Hou, Huan Cai, Tamara Seredenina, Nicolas Arbez, Shanshan Zhu, Katherine Sommers, Jennifer Qian, Jiangyang Zhang, Susumu Mori, X William Yang, Kellie L K Tamashiro, Susan Aja, Timothy H Moran, Ruth Luthi-Carter, Bronwen Martin, Stuart Maudsley, Mark P Mattson, Robert H Cichewicz, Christopher A Ross, David M Holtzman, Dimitri Krainc & Wenzhen Duan Huntington's disease is a fatal neurodegenerative disorder caused by an expanded polyglutamine repeat in huntingtin (HTT) protein. We previously showed that calorie restriction ameliorated Huntington's disease pathogenesis and slowed disease progression in mice that model Huntington's disease (Huntington's disease mice). We now report t... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583851 Sun, 18 Dec 2011 05:00:00 +0100 5583851 http://www.medworm.com/index.php?rid=5583847&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FJqC08AL3lnM%2Fnm.2557 Authors: Wolfram Hoetzenecker, Bernd Echtenacher, Emmanuella Guenova, Konrad Hoetzenecker, Florian Woelbing, Jürgen Brück, Anna Teske, Nadejda Valtcheva, Kerstin Fuchs, Manfred Kneilling, Ji-Hyeon Park, Kyu-Han Kim, Kyu-Won Kim, Petra Hoffmann, Claus Krenn, Tsonwin Hai, Kamran Ghoreschi, Tilo Biedermann & Martin Röcken (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583847 Sun, 18 Dec 2011 05:00:00 +0100 5583847 http://www.medworm.com/index.php?rid=5583846&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FzgK0RgFNFVs%2Fnm.2601 Malaria impairs resistance to Salmonella through heme- and heme oxygenase–dependent dysfunctional granulocyte mobilization Nature Medicine 18, 120 (2012). doi:10.1038/nm.2601 Authors: Aubrey J Cunnington, J Brian de Souza, Michael Walther & Eleanor M Riley (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583846 Sun, 18 Dec 2011 05:00:00 +0100 5583846 http://www.medworm.com/index.php?rid=5583850&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FhrR4E27Tcn8%2Fnm.2574 Authors: Victor W Wong, Kristine C Rustad, Satoshi Akaishi, Michael Sorkin, Jason P Glotzbach, Michael Januszyk, Emily R Nelson, Kemal Levi, Josemaria Paterno, Ivan N Vial, Anna A Kuang, Michael T Longaker & Geoffrey C Gurtner Exuberant fibroproliferation is a common complication after injury for reasons that are not well understood. One key component of wound repair that is often overlooked is mechanical force, which regulates cell-matrix interactions through intracellular focal adhesion components, including focal adhesion kinase (FAK). Here we report that FAK is activated after cutaneous injury and that this process is potentiated by mechanical loading. Fibroblast-specific FAK knockout mice have substantially less inflammation and fibrosis than control mice in a model of hypertrophi... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583850 Sun, 11 Dec 2011 05:00:00 +0100 5583850 http://www.medworm.com/index.php?rid=5583843&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fzjk_1Coplcc%2Fnm.2546 Authors: Robert Amson, Salvatore Pece, Alexandra Lespagnol, Rajesh Vyas, Giovanni Mazzarol, Daniela Tosoni, Ivan Colaluca, Giuseppe Viale, Sylvie Rodrigues-Ferreira, Jessika Wynendaele, Olivier Chaloin, Johan Hoebeke, Jean-Christophe Marine, Pier Paolo Di Fiore & Adam Telerman (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583843 Sun, 11 Dec 2011 05:00:00 +0100 5583843 http://www.medworm.com/index.php?rid=5583841&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F-rVWhQ38l3M%2Fnm.2577 EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers Nature Medicine 18, 74 (2012). doi:10.1038/nm.2577 Authors: Michela Garofalo, Giulia Romano, Gianpiero Di Leva, Gerard Nuovo, Young-Jun Jeon, Apollinaire Ngankeu, Jin Sun, Francesca Lovat, Hansjuerg Alder, Gerolama Condorelli, Jeffrey A Engelman, Mayumi Ono, Jin Kyung Rho, Luciano Cascione, Stefano Volinia, Kenneth P Nephew & Carlo M Croce (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583841 Sun, 11 Dec 2011 05:00:00 +0100 5583841 http://www.medworm.com/index.php?rid=5583840&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F5T_v5NU9aC8%2Fnm.2548 Authors: Anette Schneider, Christian Thiel, Jan Rindermann, Charles DeRossi, Diana Popovici, Georg F Hoffmann, Hermann-Josef Gröne & Christian Körner Congenital disorder of glycosylation-Ia (CDG-Ia, also known as PMM2-CDG) is caused by mutations in the gene that encodes phosphomannomutase 2 (PMM2, EC 5.4.2.8) leading to a multisystemic disease with severe psychomotor and mental retardation. In a hypomorphic Pmm2 mouse model, we were able to overcome embryonic lethality by feeding mannose to pregnant dams. The results underline the essential role of glycosylation in embryonic development and may open new treatment options for this disease. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583840 Sun, 11 Dec 2011 05:00:00 +0100 5583840 http://www.medworm.com/index.php?rid=5477774&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FFLahVxYl_lA%2Fnm1211-1693d Nature Medicine 17, 1693 (2011). doi:10.1038/nm1211-1693d Author: Dennis J Selkoe (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477774 Tue, 06 Dec 2011 05:00:00 +0100 5477774 http://www.medworm.com/index.php?rid=5477773&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FVUBZKy-3QXQ%2Fnm1211-1693c Nature Medicine 17, 1693 (2011). doi:10.1038/nm1211-1693c Author: Xu Cao (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477773 Tue, 06 Dec 2011 05:00:00 +0100 5477773 http://www.medworm.com/index.php?rid=5477772&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FlHrgHtC315I%2Fnm1211-1693b Authors: Baofeng Yang, Huixian Lin, Jiening Xiao, Yanjie Lu, Xiaobin Luo, Baoxin Li, Ying Zhang, Chaoqian Xu, Yunlong Bai, Huizhen Wang, Guohao Chen & Zhiguo Wang (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477772 Tue, 06 Dec 2011 05:00:00 +0100 5477772 http://www.medworm.com/index.php?rid=5477770&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FE6KJhYBzQn4%2Fnm1211-1692 Authors: Scott G Hansen, Cassandra Vieville, Nathan Whizin, Lia Coyne-Johnson, Don C Siess, Derek D Drummond, Alfred W Legasse, Michael K Axthelm, Kelli Oswald, Charles M Trubey, Michael Piatak, Jeffrey D Lifson, Jay A Nelson, Michael A Jarvis & Louis J Picker (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477770 Tue, 06 Dec 2011 05:00:00 +0100 5477770 http://www.medworm.com/index.php?rid=5477752&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FkSuib2Ro-uQ%2Fnm.2504 Authors: Gustavo Tiscornia, Erica Lorenzo Vivas & Juan Carlos Izpisúa Belmonte (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477752 Tue, 06 Dec 2011 05:00:00 +0100 5477752 http://www.medworm.com/index.php?rid=5477751&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FKQr3SyKBo9g%2Fnm.2583 Authors: Stefan R Bornstein & Julio Licinio (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477751 Tue, 06 Dec 2011 05:00:00 +0100 5477751 http://www.medworm.com/index.php?rid=5477750&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fx6mYUNarc2Q%2Fnm.2607 Nature Medicine 17, 1566 (2011). doi:10.1038/nm.2607 Author: Michael Basson (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477750 Tue, 06 Dec 2011 05:00:00 +0100 5477750 http://www.medworm.com/index.php?rid=5477749&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FFIBseP110_c%2Fnm.2606 Nature Medicine 17, 1566 (2011). doi:10.1038/nm.2606 Author: Alison Farrell (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477749 Tue, 06 Dec 2011 05:00:00 +0100 5477749 http://www.medworm.com/index.php?rid=5477748&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FYrrZc0TNANo%2Fnm.2605 Nature Medicine 17, 1566 (2011). doi:10.1038/nm.2605 Author: Juan Carlos López (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477748 Tue, 06 Dec 2011 05:00:00 +0100 5477748 http://www.medworm.com/index.php?rid=5477747&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FWyEBpUiBcu0%2Fnm.2604 Nature Medicine 17, 1566 (2011). doi:10.1038/nm.2604 Author: Meera Swami (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477747 Tue, 06 Dec 2011 05:00:00 +0100 5477747 http://www.medworm.com/index.php?rid=5477746&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F4UIlJhHAVtI%2Fnm.2594 Authors: Amander T Clark, Bart T Phillips & Kyle E Orwig (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477746 Tue, 06 Dec 2011 05:00:00 +0100 5477746 http://www.medworm.com/index.php?rid=5477745&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FM2QJj7s2tfo%2Fnm.2595 Authors: Min Xu, Mary Ellen Pavone & Teresa Woodruff Chemotherapy can save the lives of many individuals with cancer. Unfortunately, it usually causes infertility after treatment, posing a concern for these people who will face a lifetime condition that considerably limits the quality of their lives. Advances in the field of oncofertility have brought hope to cancer survivors who long to plan a family; however, standard approaches only rely on cryopreservation of sperms and eggs before treatment and do not prevent infertility. In 'Bedside to Bench', Min Xu, Mary Ellen Pavone and Teresa Woodruff examine a study where individuals treated with gonadotropin-releasing hormone (GnRH) agonists before cancer therapy showed a decreased risk of infertility. How these agonists work to suppress an... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477745 Tue, 06 Dec 2011 05:00:00 +0100 5477745 http://www.medworm.com/index.php?rid=5477744&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Ff6-yY1IeYJE%2Fnm1211-1560 Nature Medicine 17, 1560 (2011). doi:10.1038/nm1211-1560 (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477744 Tue, 06 Dec 2011 05:00:00 +0100 5477744 http://www.medworm.com/index.php?rid=5477743&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FQuA-zr57VDM%2Fnm.2599 Authors: Anita Huttner & Pasko Rakic The discovery that skin cells from an adult human can be reprogrammed back to their embryonic stage and then differentiated to produce neuron-like cells in culture opens an opportunity to study disease pathogenesis and screen potential therapeutic drugs. A new study provides an example of this approach for the neuropsychiatric disorder Timothy syndrome (pages 1657–1662). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477743 Tue, 06 Dec 2011 05:00:00 +0100 5477743 http://www.medworm.com/index.php?rid=5477742&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fm5IO-1c24WE%2Fnm.2591 Authors: Mark T Gladwin & Jesús Tejero Cellular production of nitric oxide (NO) by nitric oxide synthase (NOS) in the face of limiting pools of arginine requires the intracellular citrulline-to-NO pathway, catalyzed by the enzyme argininosuccinate lyase (ASL). People with the urea cycle disorder argininosuccinic aciduria, caused by a deficiency of ASL, have systemic NO deficiency, which can be rescued by the use of an alternative, NOS-independent, nitrite-to-NO pathway. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477742 Tue, 06 Dec 2011 05:00:00 +0100 5477742 http://www.medworm.com/index.php?rid=5477741&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FOwA6mfhQ6yU%2Fnm.2586 NF-κB in DCs: it takes effort to be immature Nature Medicine 17, 1554 (2011). doi:10.1038/nm.2586 Author: Rémi J Creusot The nuclear factor-κB (NF-κB) family of regulators is well known for mediating dendritic cell (DC) maturation—that is, the acquisition of the functions required for full activation of T cells. Paradoxically, a key member of this family, NF-κB1, is now also implicated in maintaining DCs in an immature state (pages 1663–1667). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477741 Tue, 06 Dec 2011 05:00:00 +0100 5477741 http://www.medworm.com/index.php?rid=5477740&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FJb-QY5UOprg%2Fnm.2593 Nature Medicine 17, 1552 (2011). doi:10.1038/nm.2593 Author: Erik A C Wiemer miR-200 family expression results in highly proliferative ovarian cancer cells. Yet this expression is also linked to longer overall survival in women with ovarian cancer. A new study sheds light into this apparent paradox showing that two members of this family—miR-141 and miR-200a—not only boost tumor growth but also sensitize tumor cells to chemotherapy (pages 1627–1635). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477740 Tue, 06 Dec 2011 05:00:00 +0100 5477740 http://www.medworm.com/index.php?rid=5477739&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F2LrRVM__9hk%2Fnm.2587 Authors: Rino Rappuoli & Ennio De Gregorio Although protein-polysaccharide conjugate vaccines provide notable clinical benefits, it is still not fully understood how they work. A new mechanism of action for these vaccines has been identified in which T cells can recognize sugar epitopes in the context of the major histocompatibility complex (MHC) provided they are bound to a protein 'anchor', which allows binding of the sugar epitope to the MHC (pages 1602–1609). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477739 Tue, 06 Dec 2011 05:00:00 +0100 5477739 http://www.medworm.com/index.php?rid=5477738&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F2Z6VtUO2FYM%2Fnm.2592 Authors: Alejo Chorny & Andrea Cerutti IgA regulates intestinal homeostasis by maintaining appropriate communities of bacteria within the gut. A new study shows that intestinal bacteria regulate metabolism via IgA (pages 1585–1593). (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477738 Tue, 06 Dec 2011 05:00:00 +0100 5477738 http://www.medworm.com/index.php?rid=5477737&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fi0OicXK8yJw%2Fnm.2589 Reply to: Mannose-binding lectin—the forgotten molecule? Nature Medicine 17, 1548 (2011). doi:10.1038/nm.2589 Authors: Costantino Iadecola & Josef Anrather (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477737 Tue, 06 Dec 2011 05:00:00 +0100 5477737 http://www.medworm.com/index.php?rid=5477736&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FUbgpzGTqi-Q%2Fnm.2588 Mannose-binding lectin—the forgotten molecule? Nature Medicine 17, 1547 (2011). doi:10.1038/nm.2588 Authors: Michael Osthoff, George Trendelenburg, Damon P Eisen & Marten Trendelenburg (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477736 Tue, 06 Dec 2011 05:00:00 +0100 5477736 http://www.medworm.com/index.php?rid=5477735&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FXWQEMeTlzl0%2Fnm.2585 Nature Medicine 17, 1545 (2011). doi:10.1038/nm.2585 Author: Katherine A. High (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477735 Tue, 06 Dec 2011 05:00:00 +0100 5477735 http://www.medworm.com/index.php?rid=5477734&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FJ6iiTOcRomM%2Fnm1211-1544 Nature Medicine 17, 1544 (2011). doi:10.1038/nm1211-1544 (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477734 Tue, 06 Dec 2011 05:00:00 +0100 5477734 http://www.medworm.com/index.php?rid=5477733&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Few6iyT4YtA4%2Fnm1211-1543 Nature Medicine 17, 1543 (2011). doi:10.1038/nm1211-1543 (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477733 Tue, 06 Dec 2011 05:00:00 +0100 5477733 http://www.medworm.com/index.php?rid=5477732&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fa0R2KUhQCNw%2Fnm1211-1542 Nature Medicine 17, 1542 (2011). doi:10.1038/nm1211-1542 Here we present the in-gene-ious cancer drugs, sanguine blood thinners and others of 2011 as we look back on this year's major headlines related to medications. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477732 Tue, 06 Dec 2011 05:00:00 +0100 5477732 http://www.medworm.com/index.php?rid=5477731&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FZp7AfRCa8_E%2Fnm1211-1540 Nature Medicine 17, 1540 (2011). doi:10.1038/nm1211-1540 We look back on some of the key insights into biomedicine published this year. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477731 Tue, 06 Dec 2011 05:00:00 +0100 5477731 http://www.medworm.com/index.php?rid=5477730&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fny49kbLZM10%2Fnm1211-1539b Nature Medicine 17, 1539 (2011). doi:10.1038/nm1211-1539b We list key people who made headlines this year, either by standing up for what they saw as right or by stopping what they felt was wrong. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477730 Tue, 06 Dec 2011 05:00:00 +0100 5477730 http://www.medworm.com/index.php?rid=5477729&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F4TJg4tnn930%2Fnm1211-1539a Nature Medicine 17, 1539 (2011). doi:10.1038/nm1211-1539a (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477729 Tue, 06 Dec 2011 05:00:00 +0100 5477729 http://www.medworm.com/index.php?rid=5477728&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FB7ZoOvENEJA%2Fnm1211-1536 Nature Medicine 17, 1536 (2011). doi:10.1038/nm1211-1536 Author: Alla Katsnelson Scientists had long assumed that any genetic mutation that does not alter a protein sequence should have no impact on human health. But recent research has shown that such synonymous DNA changes can trigger disease in a number of ways. Alla Katsnelson talks to scientists and biotech companies who are speaking up about 'silent' mutations. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477728 Tue, 06 Dec 2011 05:00:00 +0100 5477728 http://www.medworm.com/index.php?rid=5477727&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fm4Y3Fiu2tAE%2Fnm1211-1535 Authors: Emma A Meagher & Garret A FitzGerald The path to drug approval is long, hard and often perplexing. In recent months, the US Food and Drug Administration (FDA) has promised to bolster 'regulatory science', which aims to transform its decision-making process to be more efficient, transparent and accountable. However, diverse stakeholders, including patients, drug developers and the US Congress, will have to rise to the challenge of coordinating their priorities if this endeavor is to succeed. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477727 Tue, 06 Dec 2011 05:00:00 +0100 5477727 http://www.medworm.com/index.php?rid=5477726&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FEps6g3bhOIs%2Fnm1211-1534 Nature Medicine 17, 1534 (2011). doi:10.1038/nm1211-1534 Author: Elie Dolgin (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477726 Tue, 06 Dec 2011 05:00:00 +0100 5477726 http://www.medworm.com/index.php?rid=5477725&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FfD-GSpf1pVI%2Fnm1211-1532 Nature Medicine 17, 1532 (2011). doi:10.1038/nm1211-1532 (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477725 Tue, 06 Dec 2011 05:00:00 +0100 5477725 http://www.medworm.com/index.php?rid=5477724&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FvTxUtDmu30Y%2Fnm1211-1531b Nature Medicine 17, 1531 (2011). doi:10.1038/nm1211-1531b Author: Cassandra Willyard (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477724 Tue, 06 Dec 2011 05:00:00 +0100 5477724 http://www.medworm.com/index.php?rid=5477723&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fyk0MUlCukm8%2Fnm1211-1531a Nature Medicine 17, 1531 (2011). doi:10.1038/nm1211-1531a Author: Katharine Sanderson (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477723 Tue, 06 Dec 2011 05:00:00 +0100 5477723 http://www.medworm.com/index.php?rid=5477722&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FzJOZyrGr_5Y%2Fnm1211-1530 Nature Medicine 17, 1530 (2011). doi:10.1038/nm1211-1530 Author: Madhumita Venkataramanan (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477722 Tue, 06 Dec 2011 05:00:00 +0100 5477722 http://www.medworm.com/index.php?rid=5477721&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F99-LSVK3M-I%2Fnm1211-1529b Nature Medicine 17, 1529 (2011). doi:10.1038/nm1211-1529b (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477721 Tue, 06 Dec 2011 05:00:00 +0100 5477721 http://www.medworm.com/index.php?rid=5477720&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FikO8Qem30mY%2Fnm1211-1529a Nature Medicine 17, 1529 (2011). doi:10.1038/nm1211-1529a Author: Hannah Waters (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477720 Tue, 06 Dec 2011 05:00:00 +0100 5477720 http://www.medworm.com/index.php?rid=5477719&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FhIRaWO2b7Uw%2Fnm1211-1528a Nature Medicine 17, 1528 (2011). doi:10.1038/nm1211-1528a Author: Hannah Waters (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477719 Tue, 06 Dec 2011 05:00:00 +0100 5477719 http://www.medworm.com/index.php?rid=5477718&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FSNRDeglvxVM%2Fnm1211-1528b Nature Medicine 17, 1528 (2011). doi:10.1038/nm1211-1528b Author: Hannah Waters (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477718 Tue, 06 Dec 2011 05:00:00 +0100 5477718 http://www.medworm.com/index.php?rid=5477717&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FEiPXc5q0rQQ%2Fnm1211-1527b Nature Medicine 17, 1527 (2011). doi:10.1038/nm1211-1527b Author: Hannah Waters (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477717 Tue, 06 Dec 2011 05:00:00 +0100 5477717 http://www.medworm.com/index.php?rid=5477716&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FrRmJXlDsfB8%2Fnm1211-1527a Nature Medicine 17, 1527 (2011). doi:10.1038/nm1211-1527a Author: Hannah Waters (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477716 Tue, 06 Dec 2011 05:00:00 +0100 5477716 http://www.medworm.com/index.php?rid=5477715&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fy6MkF0Zx-o0%2Fnm1211-1526 Nature Medicine 17, 1526 (2011). doi:10.1038/nm1211-1526 Author: Sarah C P Williams (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477715 Tue, 06 Dec 2011 05:00:00 +0100 5477715 http://www.medworm.com/index.php?rid=5477714&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FJFjXG1IiXcQ%2Fnm1211-1525 Nature Medicine 17, 1525 (2011). doi:10.1038/nm1211-1525 Author: Elie Dolgin (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477714 Tue, 06 Dec 2011 05:00:00 +0100 5477714 http://www.medworm.com/index.php?rid=5477713&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FTjMg8QjuQ_8%2Fnm.2611 Nature Medicine 17, 1523 (2011). doi:10.1038/nm.2611 Retracting a paper is perhaps the most unpleasant task a journal has to face, particularly if the retraction involves scientific misconduct. With the number of retractions on the rise, an improved mechanism to deal with misconduct is necessary. (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477713 Tue, 06 Dec 2011 05:00:00 +0100 5477713 http://www.medworm.com/index.php?rid=5583854&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FI9XiDCIo4VQ%2Fnm.2590 Authors: Kathryn E Luker, Laura Anne Mihalko, Bradley T Schmidt, Sarah A Lewin, Paramita Ray, Dmitry Shcherbo, Dmitriy M Chudakov & Gary D Luker (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583854 Sun, 04 Dec 2011 05:00:00 +0100 5583854 http://www.medworm.com/index.php?rid=5583845&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F1vBjRi-TXxE%2Fnm.2550 Authors: Marina Shkreli, Kavita Y Sarin, Matthew F Pech, Natalia Papeta, Woody Chang, Stephanie A Brockman, Peggie Cheung, Eunice Lee, Frank Kuhnert, Jean L Olson, Calvin J Kuo, Ali G Gharavi, Vivette D D'Agati & Steven E Artandi (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583845 Sun, 04 Dec 2011 05:00:00 +0100 5583845 http://www.medworm.com/index.php?rid=5583844&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FAZHMstWDJuQ%2Fnm.2575 Authors: Yuan Xue, Sharon Lim, Yunlong Yang, Zongwei Wang, Lasse Dahl Ejby Jensen, Eva-Maria Hedlund, Patrik Andersson, Masakiyo Sasahara, Ola Larsson, Dagmar Galter, Renhai Cao, Kayoko Hosaka & Yihai Cao (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583844 Sun, 04 Dec 2011 05:00:00 +0100 5583844 http://www.medworm.com/index.php?rid=5583842&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fw7J5rzmb0GM%2Fnm.2540 Authors: Elena Ortiz-Zapater, David Pineda, Neus Martínez-Bosch, Gonzalo Fernández-Miranda, Mar Iglesias, Francesc Alameda, Mireia Moreno, Carolina Eliscovich, Eduardo Eyras, Francisco X Real, Raúl Méndez & Pilar Navarro (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583842 Sun, 04 Dec 2011 05:00:00 +0100 5583842 http://www.medworm.com/index.php?rid=5583848&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fd5Kq8tqSQhA%2Fnm.2597 Authors: Motoko Koyama, Rachel D Kuns, Stuart D Olver, Neil C Raffelt, Yana A Wilson, Alistair L J Don, Katie E Lineburg, Melody Cheong, Renee J Robb, Kate A Markey, Antiopi Varelias, Bernard Malissen, Günter J Hämmerling, Andrew D Clouston, Christian R Engwerda, Purnima Bhat, Kelli P A MacDonald & Geoffrey R Hill (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5583848 Tue, 29 Nov 2011 05:00:00 +0100 5583848 http://www.medworm.com/index.php?rid=5477766&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FLgWGijbH94Q%2Fnm.2490 Authors: Mohammad R Ebrahimkhani, Fiona Oakley, Lindsay B Murphy, Jelena Mann, Anna Moles, Maria J Perugorria, Elizabeth Ellis, Anne F Lakey, Alastair D Burt, Angela Douglass, Matthew C Wright, Steven A White, Fabrice Jaffré, Luc Maroteaux & Derek A Mann Tissue homeostasis requires an effective, limited wound-healing response to injury. In chronic disease, failure to regenerate parenchymal tissue leads to the replacement of lost cellular mass with a fibrotic matrix. The mechanisms that dictate the balance of cell regeneration and fibrogenesis are not well understood. Here we report that fibrogenic hepatic stellate cells (HSCs) in the liver are negative regulators of hepatocyte regeneration. This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B recept... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477766 Sun, 27 Nov 2011 05:00:00 +0100 5477766 http://www.medworm.com/index.php?rid=5477764&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F6_O0YlBgdMQ%2Fnm.2576 Authors: Sergiu P Paşca, Thomas Portmann, Irina Voineagu, Masayuki Yazawa, Aleksandr Shcheglovitov, Anca M Paşca, Branden Cord, Theo D Palmer, Sachiko Chikahisa, Seiji Nishino, Jonathan A Bernstein, Joachim Hallmayer, Daniel H Geschwind & Ricardo E Dolmetsch Monogenic neurodevelopmental disorders provide key insights into the pathogenesis of disease and help us understand how specific genes control the development of the human brain. Timothy syndrome is caused by a missense mutation in the L-type calcium channel Cav1.2 that is associated with developmental delay and autism. We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca2+) si... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477764 Sun, 27 Nov 2011 05:00:00 +0100 5477764 http://www.medworm.com/index.php?rid=5477763&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FcC00qnLz7dg%2Fnm.2579 Authors: Merit Cudkowicz, Michael E Bozik, Evan W Ingersoll, Robert Miller, Hiroshi Mitsumoto, Jeremy Shefner, Dan H Moore, David Schoenfeld, James L Mather, Donald Archibald, Mary Sullivan, Craig Amburgey, Juliet Moritz & Valentin K Gribkoff Amyotrophic lateral sclerosis (ALS) is characterized by upper and lower motor neuron dysfunction and loss, rapidly progressive muscle weakness, wasting and death. Many factors, including mitochondrial dysfunction, may contribute to ALS pathogenesis. Riluzole, which has shown only modest benefits in a measure of survival time without demonstrated effects on muscle strength or function, is the only approved treatment for ALS. We tested the putative mitochondrial modulator dexpramipexole (KNS-760704; (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazol... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477763 Sun, 20 Nov 2011 05:00:00 +0100 5477763 http://www.medworm.com/index.php?rid=5477762&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FymZyyobmncg%2Fnm.2580 Authors: Dan R Robinson, Shanker Kalyana-Sundaram, Yi-Mi Wu, Sunita Shankar, Xuhong Cao, Bushra Ateeq, Irfan A Asangani, Matthew Iyer, Christopher A Maher, Catherine S Grasso, Robert J Lonigro, Michael Quist, Javed Siddiqui, Rohit Mehra, Xiaojun Jing, Thomas J Giordano, Michael S Sabel, Celina G Kleer, Nallasivam Palanisamy, Rachael Natrajan, Maryou B Lambros, Jorge S Reis-Filho, Chandan Kumar-Sinha & Arul M Chinnaiyan Breast cancer is a heterogeneous disease that has a wide range of molecular aberrations and clinical outcomes. Here we used paired-end transcriptome sequencing to explore the landscape of gene fusions in a panel of breast cancer cell lines and tissues. We observed that individual breast cancers have a variety of expressed gene fusions. We identified two classes of recurr... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477762 Sun, 20 Nov 2011 05:00:00 +0100 5477762 http://www.medworm.com/index.php?rid=5477759&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FhdiJUnPCgxY%2Fnm.2512 Authors: Bogdan Mateescu, Luciana Batista, Melissa Cardon, Tina Gruosso, Yvan de Feraudy, Odette Mariani, André Nicolas, Jean-Philippe Meyniel, Paul Cottu, Xavier Sastre-Garau & Fatima Mechta-Grigoriou (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477759 Sun, 20 Nov 2011 05:00:00 +0100 5477759 http://www.medworm.com/index.php?rid=5477756&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FBrdW2AhMxDg%2Fnm.2535 Authors: Fikri Y Avci, Xiangming Li, Moriya Tsuji & Dennis L Kasper (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477756 Sun, 20 Nov 2011 05:00:00 +0100 5477756 http://www.medworm.com/index.php?rid=5477755&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FruGxIcA2Zjk%2Fnm.2542 Mesenchymal stem cell–based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α Nature Medicine 17, 1594 (2011). doi:10.1038/nm.2542 Authors: Yi Liu, Lei Wang, Takashi Kikuiri, Kentaro Akiyama, Chider Chen, Xingtian Xu, Ruili Yang, WanJun Chen, Songlin Wang & Songtao Shi (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477755 Sun, 20 Nov 2011 05:00:00 +0100 5477755 http://www.medworm.com/index.php?rid=5477754&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FIPx3G524hYk%2Fnm.2505 Authors: Natalia Shulzhenko, Andrey Morgun, William Hsiao, Michele Battle, Michael Yao, Oksana Gavrilova, Marlene Orandle, Lloyd Mayer, Andrew J Macpherson, Kathy D McCoy, Claire Fraser-Liggett & Polly Matzinger (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477754 Sun, 20 Nov 2011 05:00:00 +0100 5477754 http://www.medworm.com/index.php?rid=5477765&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FLWJLgCKc0aY%2Fnm.2556 Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells Nature Medicine 17, 1663 (2011). doi:10.1038/nm.2556 Authors: Dilan Dissanayake, Håkan Hall, Nancy Berg-Brown, Alisha R Elford, Sara R Hamilton, Kiichi Murakami, Leslie Summers Deluca, Jennifer L Gommerman & Pamela S Ohashi Mature dendritic cells (DCs) are crucial for the induction of adaptive immune responses and perturbed DC homeostasis can result in autoimmune disease. Either uncontrolled expansion or enhanced survival of DCs can result in a variety of autoimmune diseases in mouse models. In addition, increased maturation signals, through overexpression of surface Toll-like receptors (TLRs) or stimulation by type I interferon (IFN), has been... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477765 Sun, 13 Nov 2011 05:00:00 +0100 5477765 http://www.medworm.com/index.php?rid=5477761&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2Fo0ohmEyqW5c%2Fnm.2464 Authors: Ainhoa Mielgo, Laetitia Seguin, Miller Huang, Maria Fernanda Camargo, Sudarshan Anand, Aleksandra Franovic, Sara M Weis, Sunil J Advani, Eric A Murphy & David A Cheresh RAF kinases regulate cell proliferation and survival and can be dysregulated in tumors. The role of RAF in cell proliferation has been linked to its ability to activate mitogen-activated protein kinase kinase 1 (MEK) and mitogen-activated protein kinase 1 (ERK). Here we identify a MEK-independent role for RAF in tumor growth. Specifically, in mitotic cells, CRAF becomes phosphorylated on Ser338 and localizes to the mitotic spindle of proliferating tumor cells in vitro as well as in murine tumor models and in biopsies from individuals with cancer. Treatment of tumors with allosteric inhibitors, but not ATP-compe... Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477761 Sun, 13 Nov 2011 05:00:00 +0100 5477761 http://www.medworm.com/index.php?rid=5477758&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2FBFApqdKqZPg%2Fnm.2544 Authors: Ayelet Erez, Sandesh C S Nagamani, Oleg A Shchelochkov, Muralidhar H Premkumar, Philippe M Campeau, Yuqing Chen, Harsha K Garg, Li Li, Asad Mian, Terry K Bertin, Jennifer O Black, Heng Zeng, Yaoping Tang, Anilkumar K Reddy, Marshall Summar, William E O'Brien, David G Harrison, William E Mitch, Juan C Marini, Judy L Aschner, Nathan S Bryan & Brendan Lee (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477758 Sun, 13 Nov 2011 05:00:00 +0100 5477758 http://www.medworm.com/index.php?rid=5477757&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F7oW_i_r_JTI%2Fnm.2506 Authors: B Julie He, Mei-ling A Joiner, Madhu V Singh, Elizabeth D Luczak, Paari Dominic Swaminathan, Olha M Koval, William Kutschke, Chantal Allamargot, Jinying Yang, Xiaoqun Guan, Kathy Zimmerman, Isabella M Grumbach, Robert M Weiss, Douglas R Spitz, Curt D Sigmund, W Matthijs Blankesteijn, Stephane Heymans, Peter J Mohler & Mark E Anderson (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477757 Sun, 13 Nov 2011 05:00:00 +0100 5477757 http://www.medworm.com/index.php?rid=5477753&cid=s_30445_22_f&fid=30445&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnm%2Frss%2Fcurrent%2F%7E3%2F9tVgNpWrhbs%2Fnm.2531 A hepatocyte growth factor receptor (Met)−insulin receptor hybrid governs hepatic glucose metabolism Nature Medicine 17, 1577 (2011). doi:10.1038/nm.2531 Authors: Arlee Fafalios, Jihong Ma, Xinping Tan, John Stoops, Jianhua Luo, Marie C DeFrances & Reza Zarnegar (Source: Nature Medicine) Nature Medicine journals http://www.medworm.com/rss/comments.php?id=5477753 Sun, 13 Nov 2011 05:00:00 +0100 5477753