Nature Reviews Immunology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nature Reviews Immunology' source. Wed, 08 Feb 2012 06:43:02 +0100 Transcriptional programming of the dendritic cell network http://www.medworm.com/index.php?rid=5627789&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FQF1TM4Bi1zE%2Fnri3149 Authors: Gabrielle T. Belz & Stephen L. Nutt Specialized subsets of dendritic cells (DCs) provide a crucial link between the innate and adaptive immune responses. The genetic programme that coordinates these distinct DC subsets is controlled by both cytokines and transcription factors. The initial steps in DC specification occur in the bone marrow (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627789 Wed, 25 Jan 2012 05:00:00 +0100 5627789 How do plants achieve immunity? Defence without specialized immune cells http://www.medworm.com/index.php?rid=5627788&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FjmUh9yPNlyw%2Fnri3141 Authors: Steven H. Spoel & Xinnian Dong Vertebrates have evolved a sophisticated adaptive immune system that relies on an almost infinite diversity of antigen receptors that are clonally expressed by specialized immune cells that roam the circulatory system. These immune cells provide vertebrates with extraordinary antigen-specific immune capacity and memory, while minimizing (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627788 Wed, 25 Jan 2012 05:00:00 +0100 5627788 Immunometabolism: IL-15 provides breathing space for memory http://www.medworm.com/index.php?rid=5627785&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F56i1b4qOjcg%2Fnri3162 Nature Reviews Immunology 12, 76 (2012). doi:10.1038/nri3162 Author: Yvonne Bordon IL-15 increases mitochondrial biogenesis and spare respiratory capacity in memory T cells. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627785 Wed, 25 Jan 2012 05:00:00 +0100 5627785 T cells: The TFH-like transition of TH1 cells http://www.medworm.com/index.php?rid=5627782&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FrPuGqVynHCk%2Fnri3161 Nature Reviews Immunology 12, 74 (2012). doi:10.1038/nri3161 Author: Olive Leavy Developing TH1 cells pass through a transitional TH1–TFH cell stage. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627782 Wed, 25 Jan 2012 05:00:00 +0100 5627782 Macrophages: Linking lysosome function to macrophage homeostasis http://www.medworm.com/index.php?rid=5627780&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Foi8ckef8Qxg%2Fnri3165 Nature Reviews Immunology 12, 74 (2012). doi:10.1038/nri3165 Author: Maria Papatriantafyllou A recent study in Science reveals that equilibrative nucleoside transporter 3 (ENT3) is essential for both lysosomal function and macrophage homeostasis. Similarly to patients with lysosomal storage disease owing to ENT3 mutations, ENT3-deficient mice were found to develop splenomegaly as a result of (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627780 Wed, 25 Jan 2012 05:00:00 +0100 5627780 B cells: Protective role of innate-like B cells in sepsis http://www.medworm.com/index.php?rid=5627779&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FrYZKU4xGRU8%2Fnri3164 This study describes a protective immune role for a previously uncharacterized population of innate-like B cells. When mice were systemically treated with lipopolysaccharide (LPS) or infected with Escherichia coli, cells that produced granulocyte–macrophage colony-stimulating factor (GM-CSF) accumulated in the spleen. Surprisingly, most of these (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627779 Wed, 25 Jan 2012 05:00:00 +0100 5627779 Innate immunity: Phagocytes come back even stronger http://www.medworm.com/index.php?rid=5627778&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FHTPsjE8CQyI%2Fnri3163 Nature Reviews Immunology 12, 74 (2012). doi:10.1038/nri3163 Author: Olive Leavy Lauvau and colleagues have shown that inflammatory monocytes and neutrophils become better pathogen killers during memory responses. The authors found that the enhanced clearance of the intracellular pathogen Listeria monocytogenes following re-infection was associated with increased reactive oxygen species (ROS)-mediated bacterial killing. Indeed, higher (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627778 Wed, 25 Jan 2012 05:00:00 +0100 5627778 Expanding roles for CD4+ T cells in immunity to viruses http://www.medworm.com/index.php?rid=5627792&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F16VksCYrPR0%2Fnri3152 Authors: Susan L. Swain, K. Kai McKinstry & Tara M. Strutt Viral pathogens often induce strong effector CD4+ T cell responses that are best known for their ability to help B cell and CD8+ T cell responses. However, recent studies have uncovered additional roles for CD4+ T cells, some of (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627792 Fri, 20 Jan 2012 05:00:00 +0100 5627792 Viral immunity: Lose TRAF1, lose control http://www.medworm.com/index.php?rid=5627784&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FSfxil1hDdMU%2Fnri3160 Nature Reviews Immunology 12, 76 (2012). doi:10.1038/nri3160 Author: Lucy Bird Loss of TRAF1 expression associates with T cell dysfunction in chronic infection. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627784 Fri, 20 Jan 2012 05:00:00 +0100 5627784 Antibody responses: Neutrophils zone in to help B cells http://www.medworm.com/index.php?rid=5627777&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FEdbDeaFYvS4%2Fnri3159 Nature Reviews Immunology 12, 73 (2012). doi:10.1038/nri3159 Author: Yvonne Bordon Marginal zone neutrophils provide help for T cell-independent antibody responses. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627777 Fri, 20 Jan 2012 05:00:00 +0100 5627777 Early immune events in the induction of allergic contact dermatitis http://www.medworm.com/index.php?rid=5627790&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FcQ-tp4cNLXk%2Fnri3150 Authors: Daniel H. Kaplan, Botond Z. Igyártó & Anthony A. Gaspari The skin is a barrier site that is exposed to a wide variety of potential pathogens. As in other organs, pathogens that invade the skin are recognized by pattern-recognition receptors (PRRs). Recently, it has been recognized that PRRs are also engaged by chemical contact allergens (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627790 Fri, 13 Jan 2012 05:00:00 +0100 5627790 Mucosal immunology: Multifunctional gut IgA+ plasma cells http://www.medworm.com/index.php?rid=5627783&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FVXBKoFlb55E%2Fnri3157 Nature Reviews Immunology 12, 75 (2012). doi:10.1038/nri3157 Author: Olive Leavy IgA+ plasma cells in the gut acquire novel effector mechanisms to maintain homeostasis. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627783 Fri, 13 Jan 2012 05:00:00 +0100 5627783 Immunomodulatory functions of type I interferons http://www.medworm.com/index.php?rid=5627791&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F6_mUsNeWEss%2Fnri3133 Authors: José M. González-Navajas, Jongdae Lee, Michael David & Eyal Raz Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector cytokines of the host immune response against viral infections. However, the production of type I IFNs is also induced in response to bacterial ligands of innate immune receptors and/or bacterial infections, (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627791 Fri, 06 Jan 2012 05:00:00 +0100 5627791 Autoimmunity: Interfering with brain inflammation http://www.medworm.com/index.php?rid=5627786&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FaGlYDgbeWdU%2Fnri3154 Nature Reviews Immunology 12, 77 (2012). doi:10.1038/nri3154 Author: Kirsty Minton A potential new strategy to improve the therapeutic efficacy of targeting the type I IFN pathway in multiple sclerosis. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627786 Fri, 30 Dec 2011 05:00:00 +0100 5627786 Trafficking: Effector T cells cross the line http://www.medworm.com/index.php?rid=5627781&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fj3h5wB7i5BY%2Fnri3153 Nature Reviews Immunology 12, 74 (2012). doi:10.1038/nri3153 Author: Maria Papatriantafyllou Intraendothelial chemokine-containing vesicles promote transendothelial T cell migration. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627781 Fri, 30 Dec 2011 05:00:00 +0100 5627781 Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways http://www.medworm.com/index.php?rid=5627787&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F5t0dyvOh5c0%2Fnri3131 Authors: Edward S. Mocarski, Jason W. Upton & William J. Kaiser Pathogens specifically target both the caspase 8-dependent apoptotic cell death pathway and the necrotic cell death pathway that is dependent on receptor-interacting protein 1 (RIP1; also known as RIPK1) and RIP3 (also known as RIPK3). The fundamental co-regulation of these two cell death pathways emerged (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5627787 Fri, 23 Dec 2011 05:00:00 +0100 5627787 The bone marrow at the crossroads of blood and immunity http://www.medworm.com/index.php?rid=5537254&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FBM31QHVbyzU%2Fnri3132 Authors: Francois E. Mercier, Christine Ragu & David T. Scadden Progenitor cells that are the basis for all blood cell production share the bone marrow with more mature elements of the adaptive immune system. Specialized niches within the bone marrow guide and, at times, constrain the development of haematopoietic stem and progenitor cells (HSPCs) and (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537254 Fri, 23 Dec 2011 05:00:00 +0100 5537254 B cells: Maturity matters for IgE class switch http://www.medworm.com/index.php?rid=5537250&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F6WzC6giTFb4%2Fnri3147 Nature Reviews Immunology 12, 7 (2012). doi:10.1038/nri3147 Author: Olive Leavy Class-switch recombination (CSR) in mature B cells activated under T helper 2 (TH2)-type conditions generates IgG1 and IgE isotypes. Now, Wesemann et al. report that CSR during early B cell developmental stages favours the IgE over the IgG1 isotype. Activated immature B (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537250 Fri, 23 Dec 2011 05:00:00 +0100 5537250 T cells: Heating up T cell activation http://www.medworm.com/index.php?rid=5537249&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FtHPn2XylXhs%2Fnri3146 This study found that incubation of naive CD8+ T cells at 39.5°C prior to antigen-specific activation resulted in enhanced differentiation of these cells into (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537249 Fri, 23 Dec 2011 05:00:00 +0100 5537249 Macrophages: Responding to a chill by alternative activation http://www.medworm.com/index.php?rid=5537248&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FjtVIGIl3rrM%2Fnri3145 Nature Reviews Immunology 12, 7 (2012). doi:10.1038/nri3145 Author: Olive Leavy Non-shivering thermogenesis, which is required to maintain core body temperature, involves the induction of lipolysis and the expression of thermogenic genes in adipose tissues. Ajay Chawla and colleagues now show a role for interleukin-4 (IL-4) and alternatively activated macrophages in this process. The expression of (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537248 Fri, 23 Dec 2011 05:00:00 +0100 5537248 Mucosal immunology: A safety catch to prevent intestinal inflammation http://www.medworm.com/index.php?rid=5537246&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FREP4jb_QY8o%2Fnri3144 Nature Reviews Immunology 12, 6 (2012). doi:10.1038/nri3144 Author: Kirsty Minton Intestinal dendritic cells make the requirements for TH17 cell induction in the gut more stringent than in systemic tissues. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537246 Fri, 23 Dec 2011 05:00:00 +0100 5537246 Immunotherapy: Low-dose IL-2 therapy expands human regulatory T cell populations http://www.medworm.com/index.php?rid=5537245&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FXzL4cyWudO8%2Fnri3140 Nature Reviews Immunology 12, 6 (2012). doi:10.1038/nri3140 Interleukin-2 (IL-2) promotes both effector T and regulatory T (TReg) cell responses, but it is believed that TReg cells may be more sensitive to IL-2. Two recent studies found that low-dose IL-2 therapy preferentially expands TReg cell populations in (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537245 Fri, 23 Dec 2011 05:00:00 +0100 5537245 Technique: New strategies for boosting immunity to pathogens and cancer http://www.medworm.com/index.php?rid=5537244&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fw4X7qfEWL4c%2Fnri3139 Nature Reviews Immunology 12, 6 (2012). doi:10.1038/nri3139 There is a continued need to develop better vaccines or alternative immune-stimulating therapies. Three recent studies focus on new strategies for boosting host immunity. In the setting of cancer, although potential target antigens are known, there is a requirement for a delivery strategy that enables (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537244 Fri, 23 Dec 2011 05:00:00 +0100 5537244 Natural killer T cells: More help for B cells http://www.medworm.com/index.php?rid=5537243&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FHT_Zm3jNpMw%2Fnri3148 Nature Reviews Immunology 12, 5 (2012). doi:10.1038/nri3148 Author: Olive Leavy Invariant NKT cells can provide cognate help for B cell responses. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537243 Fri, 23 Dec 2011 05:00:00 +0100 5537243 Neuroimmunology: A CNS guard as prickly as a hedgehog http://www.medworm.com/index.php?rid=5537242&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FF66lVs5hGY8%2Fnri3143 Nature Reviews Immunology 12, 4 (2012). doi:10.1038/nri3143 Author: Maria Papatriantafyllou Hedgehog signalling protects against neuroinflammation. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537242 Fri, 23 Dec 2011 05:00:00 +0100 5537242 Mucosal immunology: Hungry for the fight http://www.medworm.com/index.php?rid=5537238&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fd1iYXQA2QNE%2Fnri3136 Nature Reviews Immunology 12, 2 (2012). doi:10.1038/nri3136 Author: Yvonne Bordon Intestinal epithelial cells switch from metabolic to immune functions in the absence of B cells. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537238 Fri, 23 Dec 2011 05:00:00 +0100 5537238 Immune regulation: Immune response to tissue stress http://www.medworm.com/index.php?rid=5537237&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FN0U-bXQMAA8%2Fnri3142 Nature Reviews Immunology 12, 1 (2012). doi:10.1038/nri3142 Author: Maria Papatriantafyllou Polymorphic NKG2D ligands regulate γδ Τ cell responses to tissue stress. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537237 Fri, 23 Dec 2011 05:00:00 +0100 5537237 Vaccines targeting drugs of abuse: is the glass half-empty or half-full? http://www.medworm.com/index.php?rid=5537256&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FfPCEaI8-VgQ%2Fnri3130 Authors: Kim D. Janda & Jennifer B. Treweek The advent of vaccines targeting drugs of abuse heralded a fundamentally different approach to treating substance-related disorders. In contrast to traditional pharmacotherapies for drug abuse, vaccines act by sequestering circulating drugs and terminating the drug-induced 'high' without inducing unwanted neuromodulatory effects. Drug-targeting vaccines have entered (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537256 Fri, 16 Dec 2011 05:00:00 +0100 5537256 Inflammation: Trauma kicks up a storm http://www.medworm.com/index.php?rid=5537240&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FA9VrG9NDTfI%2Fnri3138 Nature Reviews Immunology 12, 3 (2012). doi:10.1038/nri3138 Author: Olive Leavy Serious trauma in humans is associated with a genomic storm in leukocytes. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537240 Fri, 16 Dec 2011 05:00:00 +0100 5537240 Viral immunity: Shelter from interferons http://www.medworm.com/index.php?rid=5537239&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FQQUwtqT0XTM%2Fnri3137 Nature Reviews Immunology 12, 2 (2012). doi:10.1038/nri3137 Author: Lucy Bird CD169+ macrophages allow viral replication for the promotion of adaptive immunity. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537239 Fri, 16 Dec 2011 05:00:00 +0100 5537239 The role of ubiquitylation in immune defence and pathogen evasion http://www.medworm.com/index.php?rid=5537253&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FHNW_QIO0rBE%2Fnri3111 Authors: Xiaomo Jiang & Zhijian J. Chen Ubiquitylation is a widely used post-translational protein modification that regulates many biological processes, including immune responses. The role of ubiquitin in immune regulation was originally uncovered through studies of antigen presentation and the nuclear factor-κB family of transcription factors, which orchestrate host defence against microorganisms. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537253 Fri, 09 Dec 2011 05:00:00 +0100 5537253 Molecular programming of B cell memory http://www.medworm.com/index.php?rid=5537252&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FaKPViwlEFms%2Fnri3128 Authors: Michael McHeyzer-Williams, Shinji Okitsu, Nathaniel Wang & Louise McHeyzer-Williams The development of high-affinity B cell memory is regulated through three separable phases, each involving antigen recognition by specific B cells and cognate T helper cells. Initially, antigen-primed B cells require cognate T cell help to gain entry into the germinal centre pathway to memory. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537252 Fri, 09 Dec 2011 05:00:00 +0100 5537252 The impact of perinatal immune development on mucosal homeostasis and chronic inflammation http://www.medworm.com/index.php?rid=5537251&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FtBJMANsSa4Y%2Fnri3112 Authors: Harald Renz, Per Brandtzaeg & Mathias Hornef The mucosal surfaces of the gut and airways have important barrier functions and regulate the induction of immunological tolerance. The rapidly increasing incidence of chronic inflammatory disorders of these surfaces, such as inflammatory bowel disease and asthma, indicates that the immune functions of these mucosae (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537251 Fri, 09 Dec 2011 05:00:00 +0100 5537251 Innate immunity: TLR9 mutations reveal a new level of self tolerance http://www.medworm.com/index.php?rid=5537247&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fu3-xYLzhgAI%2Fnri3134 Nature Reviews Immunology 12, 7 (2012). doi:10.1038/nri3134 Author: Maria Papatriantafyllou Processing-independent activation of a TLR9 mutant overcomes self tolerance. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537247 Fri, 09 Dec 2011 05:00:00 +0100 5537247 Regulatory T cells: Practise makes perfect http://www.medworm.com/index.php?rid=5537241&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FxPGYQtx7dAM%2Fnri3135 Nature Reviews Immunology 12, 4 (2012). doi:10.1038/nri3135 Author: Yvonne Bordon Regulatory T cells develop into memory populations that limit autoimmune attacks. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537241 Fri, 09 Dec 2011 05:00:00 +0100 5537241 Experimental mouse tumour models: what can be learnt about human cancer immunology? http://www.medworm.com/index.php?rid=5537255&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FD6A7FiudSdk%2Fnri3129 Nature Reviews Immunology 12, 61 (2012). doi:10.1038/nri3129 Author: Glenn Dranoff The recent demonstration that cancer immunotherapy extends patient survival has reinvigorated interest in elucidating the role of immunity in tumour pathogenesis. Experimental mouse tumour models have provided key mechanistic insights into host antitumour immune responses, and these have guided the development of novel treatment strategies. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5537255 Fri, 02 Dec 2011 05:00:00 +0100 5537255 The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses http://www.medworm.com/index.php?rid=5449410&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FAgkxUu57iH4%2Fnri3108 Authors: Lucy S. K. Walker & David M. Sansom The T cell protein cytotoxic T lymphocyte antigen 4 (CTLA4) was identified as a crucial negative regulator of the immune system over 15 years ago, but its mechanisms of action are still under debate. It has long been suggested that CTLA4 transmits an inhibitory signal (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449410 Fri, 25 Nov 2011 05:00:00 +0100 5449410 Immune responses: Platelets drive shuttle buggy http://www.medworm.com/index.php?rid=5449404&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FhkSxKKoftjc%2Fnri3121 Nature Reviews Immunology 11, 804 (2011). doi:10.1038/nri3121 Author: Yvonne Bordon Platelets associate with Gram-positive bacteria to promote targeting to DCs. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449404 Fri, 25 Nov 2011 05:00:00 +0100 5449404 T cell memory: The ID of memory CD8+ T cells http://www.medworm.com/index.php?rid=5449402&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FTR1Q_-4xJFM%2Fnri3127 Nature Reviews Immunology 11, 803 (2011). doi:10.1038/nri3127 Author: Maria Papatriantafyllou Two recent studies published in Nature Immunology describe the differential expression of the transcriptional regulator ID3 in short-lived effector and long-lived memory CD8+ T cell subsets and its role in memory CD8+ T cell generation. Yang et al. identified (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449402 Fri, 25 Nov 2011 05:00:00 +0100 5449402 T cell memory: Identifying memory CD4+ T cell precursors http://www.medworm.com/index.php?rid=5449401&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FndjyhywlytE%2Fnri3126 Nature Reviews Immunology 11, 803 (2011). doi:10.1038/nri3126 Author: Yvonne Bordon Two groups have tracked CD4+ T cells in infected mice to determine how memory CD4+ T cell populations arise in vivo. Pepper et al. identified two CD4+ T cell populations that were present in the early stages (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449401 Fri, 25 Nov 2011 05:00:00 +0100 5449401 Innate immunity: STAT6 activation in response to viral nucleic acids http://www.medworm.com/index.php?rid=5449398&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FgSE_28Betn0%2Fnri3125 This study describes the activation of STAT6 by viral nucleic acids. STAT6 was found to interact with STING (an adaptor protein involved in sensing nucleic (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449398 Fri, 25 Nov 2011 05:00:00 +0100 5449398 Vaccines: An effective PRR-targeting adjuvant in humans http://www.medworm.com/index.php?rid=5449397&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F-K7xcRxpIJU%2Fnri3124 Nature Reviews Immunology 11, 801 (2011). doi:10.1038/nri3124 Author: Olive Leavy Studies in mice have supported the notion that agonists of pattern recognition receptors (PRRs) are promising vaccine adjuvant candidates. One such candidate is a type of synthetic double-stranded RNA (dsRNA) — polyinosinic–polycytidylic acid stabilized with poly-L-lysine (polyICLC) — which is an agonist of (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449397 Fri, 25 Nov 2011 05:00:00 +0100 5449397 Tumour immunology: How does IL-12 enhance antitumour responses? http://www.medworm.com/index.php?rid=5449396&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FOl8STl2LE-Q%2Fnri3122 Nature Reviews Immunology 11, 801 (2011). doi:10.1038/nri3122 Author: Maria Papatriantafyllou Transfer of tumour-specific CD8+ T cells that produce interleukin-12 (IL-12) was recently used to effectively treat mice with established tumours, but the underlying mechanism was unknown. Now, Kerkar et al. report that expression of the IL-12 receptor and interferon-γ by host haematopoietic (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449396 Fri, 25 Nov 2011 05:00:00 +0100 5449396 Innate immunity: A new path uncovers a wrongful conviction http://www.medworm.com/index.php?rid=5449395&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FNkb47ycYBv0%2Fnri3120 Nature Reviews Immunology 11, 801 (2011). doi:10.1038/nri3120 Author: Yvonne Bordon A non-canonical inflammasome engages caspase 11, and this caspase (not caspase 1) promotes lethal septic shock. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449395 Fri, 25 Nov 2011 05:00:00 +0100 5449395 From the editors http://www.medworm.com/index.php?rid=5449393&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FbF3GDaEGlMc%2Fnri3123 Nature Reviews Immunology 11, 799 (2011). doi:10.1038/nri3123 'Twas the night before Christmas, and deep in the house There were trillions of creatures astir in the mouse. The immune system handled the microbes with care; PGRPs would soon see them there. (p837)The T cells were nestled all (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449393 Fri, 25 Nov 2011 05:00:00 +0100 5449393 The golden anniversary of the thymus http://www.medworm.com/index.php?rid=5449414&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FRlNBIl9be-w%2Fnri3117 Nature Reviews Immunology 11, 880 (2011). doi:10.1038/nri3117 Author: Jacques F. A. P. Miller Nature Reviews Immunology11, 489–495 (2011)In the original version of this article, in the section under the title “Lymphocyte subsets” on page 491, a key reference was unintentionally omitted. At the end of the sentence “T cells (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449414 Fri, 18 Nov 2011 05:00:00 +0100 5449414 Organ-specific features of natural killer cells http://www.medworm.com/index.php?rid=5449413&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FCtiBWreM15g%2Fnri3116 Nature Reviews Immunology 11, 880 (2011). doi:10.1038/nri3116 Author: Fu-Dong Shi, Hans-Gustaf Ljunggren, Antonio La Cava & Luc Van Kaer Nature Reviews Immunology11, 658–671 (2011)In the original version of this article, in the section under the subheading “CNS-specific NK cells in disease” on page 668, the humanized antibody daclizumab was incorrectly described as being specific for (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449413 Fri, 18 Nov 2011 05:00:00 +0100 5449413 Strategies to discover regulatory circuits of the mammalian immune system http://www.medworm.com/index.php?rid=5449412&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fo76lGAYJqhY%2Fnri3109 Authors: Ido Amit, Aviv Regev & Nir Hacohen Recent advances in technologies for genome- and proteome-scale measurements and perturbations promise to accelerate discovery in every aspect of biology and medicine. Although such rapid technological progress provides a tremendous opportunity, it also demands that we learn how to use these tools effectively. One application (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449412 Fri, 18 Nov 2011 05:00:00 +0100 5449412 TLR-dependent T cell activation in autoimmunity http://www.medworm.com/index.php?rid=5449407&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FTKw6IMTvfKc%2Fnri3095 Nature Reviews Immunology 11, 807 (2011). doi:10.1038/nri3095 Author: Kingston H. G. Mills Autoimmune disease can develop as a result of a breakdown in immunological tolerance, leading to the activation of self-reactive T cells. There is an established link between infection and human autoimmune diseases. Furthermore, experimental autoimmune diseases can be induced by autoantigens that are administered together (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449407 Fri, 18 Nov 2011 05:00:00 +0100 5449407 Cytokines: IL-17C joins the family firm http://www.medworm.com/index.php?rid=5449405&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FQlGTL_QQP6M%2Fnri3118 Nature Reviews Immunology 11, 805 (2011). doi:10.1038/nri3118 Author: Yvonne Bordon IL-17C promotes innate epithelial cell responses and TH17 cell functions. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449405 Fri, 18 Nov 2011 05:00:00 +0100 5449405 Dendritic cells: Choosing the right presentation http://www.medworm.com/index.php?rid=5449403&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FU7NDKCBvnbI%2Fnri3119 Nature Reviews Immunology 11, 804 (2011). doi:10.1038/nri3119 Author: Kirsty Minton Virus-infected lymph node macrophages are 'ignored' by naive T cells to ensure optimal T cell priming on infected DCs. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449403 Fri, 18 Nov 2011 05:00:00 +0100 5449403 Peptidoglycan recognition proteins: modulators of the microbiome and inflammation http://www.medworm.com/index.php?rid=5449409&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fp5Pm_JajtqM%2Fnri3089 Authors: Julien Royet, Dipika Gupta & Roman Dziarski All animals, including humans, live in symbiotic association with microorganisms. The immune system accommodates host colonization by the microbiota, maintains microbiota–host homeostasis and defends against pathogens. This Review analyses how one family of antibacterial pattern recognition molecules — the peptidoglycan recognition proteins — has evolved (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449409 Fri, 11 Nov 2011 05:00:00 +0100 5449409 Towards a systems understanding of MHC class I and MHC class II antigen presentation http://www.medworm.com/index.php?rid=5449408&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F-LAxsAalNMM%2Fnri3084 Authors: Jacques Neefjes, Marlieke L. M. Jongsma, Petra Paul & Oddmund Bakke The molecular details of antigen processing and presentation by MHC class I and class II molecules have been studied extensively for almost three decades. Although the basic principles of these processes were laid out approximately 10 years ago, the recent years have revealed many details (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449408 Fri, 11 Nov 2011 05:00:00 +0100 5449408 Mucosal immunology: The 'AHR diet' for mucosal homeostasis http://www.medworm.com/index.php?rid=5449406&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FkhKHcKIKI78%2Fnri3115 Nature Reviews Immunology 11, 806 (2011). doi:10.1038/nri3115 Author: Olive Leavy AHR ligands derived from cruciferous vegetables promote intestinal immune function. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449406 Fri, 11 Nov 2011 05:00:00 +0100 5449406 Autoimmunity: Linking commensals with autoimmunity http://www.medworm.com/index.php?rid=5449400&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F9vERcXbxB_c%2Fnri3114 Nature Reviews Immunology 11, 802 (2011). doi:10.1038/nri3114 Author: Maria Papatriantafyllou Both the intestinal microbiota and self-antigen recognition drive autoimmune responses. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449400 Fri, 11 Nov 2011 05:00:00 +0100 5449400 Vaccines for the twenty-first century society http://www.medworm.com/index.php?rid=5449411&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FP2Jv5pyCpRQ%2Fnri3085 Authors: Rino Rappuoli, Christian W. Mandl, Steven Black & Ennio De Gregorio Vaccines have been one of the major revolutions in the history of mankind and, during the twentieth century, they eliminated most of the childhood diseases that used to cause millions of deaths. In the twenty-first century, vaccines will also play a major part in safeguarding (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449411 Fri, 04 Nov 2011 04:00:00 +0100 5449411 Infectious disease: A ray of sunshine for TB treatment http://www.medworm.com/index.php?rid=5449399&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FnE-Xd9NKOTc%2Fnri3110 Nature Reviews Immunology 11, 802 (2011). doi:10.1038/nri3110 Author: Olive Leavy Vitamin D is necessary for the IFNγ-induced antimicrobial response to M. tuberculosis. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449399 Fri, 04 Nov 2011 04:00:00 +0100 5449399 Inflammation: Under the skin http://www.medworm.com/index.php?rid=5449394&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FBm9vOT7NVs0%2Fnri3113 Nature Reviews Immunology 11, 800 (2011). doi:10.1038/nri3113 Author: Maria Papatriantafyllou Three recent studies reveal different levels of control of skin inflammation. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5449394 Fri, 04 Nov 2011 04:00:00 +0100 5449394 Studying the mononuclear phagocyte system in the molecular age http://www.medworm.com/index.php?rid=5346552&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FflGTbZM8tJk%2Fnri3087 Authors: Andrew Chow, Brian D. Brown & Miriam Merad The mononuclear phagocyte system (MPS) comprises monocytes, macrophages and dendritic cells. Tissue phagocytes share several cell surface markers, phagocytic capability and myeloid classification; however, the factors that regulate the differentiation, homeostasis and function of macrophages and dendritic cells remain largely unknown. The purpose of this (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346552 Tue, 25 Oct 2011 04:00:00 +0100 5346552 Microglial cell origin and phenotypes in health and disease http://www.medworm.com/index.php?rid=5346551&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fee0yQwx1q8A%2Fnri3086 Authors: Kaoru Saijo & Christopher K. Glass Microglia — resident myeloid-lineage cells in the brain and the spinal cord parenchyma — function in the maintenance of normal tissue homeostasis. Microglia also act as sentinels of infection and injury, and participate in both innate and adaptive immune responses in the central nervous system. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346551 Tue, 25 Oct 2011 04:00:00 +0100 5346551 Transcriptional regulation of macrophage polarization: enabling diversity with identity http://www.medworm.com/index.php?rid=5346549&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FE4kU7SyShUM%2Fnri3088 Authors: Toby Lawrence & Gioacchino Natoli In terms of both phenotype and function, macrophages have remarkable heterogeneity, which reflects the specialization of tissue-resident macrophages in microenvironments as different as liver, brain and bone. Also, marked changes in the activity and gene expression programmes of macrophages can occur when they come into (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346549 Tue, 25 Oct 2011 04:00:00 +0100 5346549 Mucosal immunology: Colonic creatures are TReg teachers http://www.medworm.com/index.php?rid=5346546&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FoTBlnnlgqaM%2Fnri3099 Nature Reviews Immunology 11, 721 (2011). doi:10.1038/nri3099 Author: Yvonne Bordon Most regulatory T cells in the colon are specific for commensal bacteria. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346546 Tue, 25 Oct 2011 04:00:00 +0100 5346546 Tumour immunology: IFNs boost cancer killers http://www.medworm.com/index.php?rid=5346542&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FhuGStfsrNQI%2Fnri3094 Nature Reviews Immunology 11, 718 (2011). doi:10.1038/nri3094 Author: Olive Leavy Type I IFN targets CD8α+ DCs for the initiation of antitumour immunity. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346542 Tue, 25 Oct 2011 04:00:00 +0100 5346542 Innate immunity: The function of innate lymphoid cells in the lung http://www.medworm.com/index.php?rid=5346540&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FwbULI8B_0dQ%2Fnri3107 Nature Reviews Immunology 11, 717 (2011). doi:10.1038/nri3107 Innate lymphoid cells (ILCs) are a diverse group of immune cells that lack expression of lymphocyte and myeloid cell surface markers and regulate immune responses through cytokine production. Monticelli et al. identified ILCs in the lungs of healthy mice and humans. These cells were (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346540 Tue, 25 Oct 2011 04:00:00 +0100 5346540 Cytokines: IL-1 family member dampens intestinal inflammation http://www.medworm.com/index.php?rid=5346539&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FnErwTmjUJEA%2Fnri3106 Nature Reviews Immunology 11, 717 (2011). doi:10.1038/nri3106 Interleukin-37 (IL-37) is an IL-1 family member found in humans, but a mouse homologue has yet to be identified. Unlike other IL-1 family members, IL-37 has emerged as an anti-inflammatory cytokine. To explore the functions of IL-37 in the intestine, the authors induced dextran sulphate (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346539 Tue, 25 Oct 2011 04:00:00 +0100 5346539 T cells: Natural TH17 cell development in the thymus http://www.medworm.com/index.php?rid=5346538&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FYgYd_3k55sY%2Fnri3101 This study describes the requirements for the development of natural TH17 cells. Unlike conventional CD4+ (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346538 Tue, 25 Oct 2011 04:00:00 +0100 5346538 B cell signalling: Right place, right time http://www.medworm.com/index.php?rid=5346537&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FWz5_jiSKLCc%2Fnri3100 Nature Reviews Immunology 11, 716 (2011). doi:10.1038/nri3100 Author: Olive Leavy BCR endocytosis compartmentalizes kinase phosphorylation and downstream signalling. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346537 Tue, 25 Oct 2011 04:00:00 +0100 5346537 T cell memory: The stem of T cell memory http://www.medworm.com/index.php?rid=5346536&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FJp2mK66OEqE%2Fnri3098 Nature Reviews Immunology 11, 716 (2011). doi:10.1038/nri3098 Author: Maria Papatriantafyllou Identification of human T memory stem cells with increased therapeutic potential. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346536 Tue, 25 Oct 2011 04:00:00 +0100 5346536 Technique: Recapitulating human TB in vitro http://www.medworm.com/index.php?rid=5346535&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F9GPoKD6Tka4%2Fnri3105 Nature Reviews Immunology 11, 716 (2011). doi:10.1038/nri3105 Studies of human tuberculosis have been hampered by the lack of an in vitro model that recapitulates all the features of a natural infection with Mycobacterium tuberculosis. This paper describes a unique combination of in vitro culture conditions that enables the generation (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346535 Tue, 25 Oct 2011 04:00:00 +0100 5346535 Monocytes: How a high-fat diet results in monocytosis http://www.medworm.com/index.php?rid=5346534&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FeG00fwt7Xac%2Fnri3104 Nature Reviews Immunology 11, 716 (2011). doi:10.1038/nri3104 Many studies have described an association between monocytosis and cardiovascular disease. This paper reports a mechanistic link between hypercholesterolaemia and monocytosis that helps to explain their combined effects on atherosclerosis. In the apolipoprotein E-deficient (Apoe−/−) mouse model of atherosclerosis, feeding a high-cholesterol (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346534 Tue, 25 Oct 2011 04:00:00 +0100 5346534 Macrophages: Arteriogenic macrophages protect against ischaemia http://www.medworm.com/index.php?rid=5346533&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FgpRDELvseVM%2Fnri3097 This study showed that a lower level of expression of the oxygen-sensing molecule PHD2 (also known as EGLN1) by macrophages (in Phd2+/− mice) can protect against ischaemic damage to heart and skeletal muscle by increasing the number of collateral arterial vessels at baseline (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346533 Tue, 25 Oct 2011 04:00:00 +0100 5346533 Immunotherapy: Stopping monocytes in their tracks http://www.medworm.com/index.php?rid=5346532&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F6gxtKa3JOOY%2Fnri3096 Nature Reviews Immunology 11, 715 (2011). doi:10.1038/nri3096 Author: Olive Leavy Therapeutic targeting of inflammatory monocyte migration attenuates disease severity. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346532 Tue, 25 Oct 2011 04:00:00 +0100 5346532 Nobel Prize to immunology http://www.medworm.com/index.php?rid=5346531&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FYxlO0ZYWzEU%2Fnri3103 Nature Reviews Immunology 11, 714 (2011). doi:10.1038/nri3103 This year's Nobel Prize to Ralph Steinman, Jules Hoffmann and Bruce Beutler marked the significance of the advances made over the past 4 decades in the field of innate immunology. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346531 Tue, 25 Oct 2011 04:00:00 +0100 5346531 In this issue http://www.medworm.com/index.php?rid=5346530&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FtLR-1e5bPUs%2Fnri3102 Nature Reviews Immunology 11, 713 (2011). doi:10.1038/nri3102 If you were to describe macrophages to a non-immunologist, you could be forgiven for using the analogy of the arcade game Pac-Man, in which Pac-Man is guided through a maze, gobbling up pac-dots. But macrophages are more than just the 'big-eaters' of the immune system, (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346530 Tue, 25 Oct 2011 04:00:00 +0100 5346530 Protective and pathogenic functions of macrophage subsets http://www.medworm.com/index.php?rid=5346547&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FmbJMXunx0Ss%2Fnri3073 Authors: Peter J. Murray & Thomas A. Wynn Macrophages are strategically located throughout the body tissues, where they ingest and process foreign materials, dead cells and debris and recruit additional macrophages in response to inflammatory signals. They are highly heterogeneous cells that can rapidly change their function in response to local microenvironmental signals. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346547 Fri, 14 Oct 2011 04:00:00 +0100 5346547 Neuroimmunology: Nervous ChAT http://www.medworm.com/index.php?rid=5346545&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FCxv2zZ_ySzY%2Fnri3091 Nature Reviews Immunology 11, 720 (2011). doi:10.1038/nri3091 Author: Isabel Woodman Acetylcholine-producing T cells convey neural signals to dampen inflammation. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346545 Fri, 14 Oct 2011 04:00:00 +0100 5346545 T cells: Lymphoid stroma says NO to activated T cells http://www.medworm.com/index.php?rid=5346544&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F24HyheQpUfo%2Fnri3090 Nature Reviews Immunology 11, 720 (2011). doi:10.1038/nri3090 Author: Maria Papatriantafyllou Activated T cells induce the production of immunosuppressive nitric oxide by stromal cells. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346544 Fri, 14 Oct 2011 04:00:00 +0100 5346544 Immune tolerance: Suicide is painless http://www.medworm.com/index.php?rid=5346543&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FiuuR2rPNnSU%2Fnri3092 Nature Reviews Immunology 11, 719 (2011). doi:10.1038/nri3092 Author: Yvonne Bordon Self-reactive T cells invade and are degraded in hepatocytes, preventing autoimmune disease. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346543 Fri, 14 Oct 2011 04:00:00 +0100 5346543 T cell memory: Exhausted T cells miss out on methylation http://www.medworm.com/index.php?rid=5346541&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FVRbWuuMApbo%2Fnri3093 Nature Reviews Immunology 11, 718 (2011). doi:10.1038/nri3093 Author: Kirsty Minton The inhibitory signal to T cells through PD1 is sustained during chronic viral infection by epigenetic mechanisms. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346541 Fri, 14 Oct 2011 04:00:00 +0100 5346541 Monocyte recruitment during infection and inflammation http://www.medworm.com/index.php?rid=5346550&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FrB6_CM08CyY%2Fnri3070 Authors: Chao Shi & Eric G. Pamer Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave the bloodstream and migrate into tissues where, following conditioning by local growth factors, pro-inflammatory cytokines and microbial products, they differentiate into (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346550 Mon, 10 Oct 2011 04:00:00 +0100 5346550 Macrophage-mediated inflammation in metabolic disease http://www.medworm.com/index.php?rid=5346548&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FvAjl08TMEgM%2Fnri3071 Authors: Ajay Chawla, Khoa D. Nguyen & Y. P. Sharon Goh Metabolism and immunity are two fundamental systems of metazoans. The presence of immune cells, such as macrophages, in metabolic tissues suggests dynamic, ongoing crosstalk between these two regulatory systems. Here, we discuss how changes in the recruitment and activation of macrophages contribute to metabolic homeostasis. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5346548 Mon, 10 Oct 2011 04:00:00 +0100 5346548 The parallel lives of angiogenesis and immunosuppression: cancer and other tales http://www.medworm.com/index.php?rid=5249972&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FIoxU9eF6y-k%2Fnri3064 Authors: Gregory T. Motz & George Coukos Emerging evidence indicates that angiogenesis and immunosuppression frequently occur simultaneously in response to diverse stimuli. Here, we describe a fundamental biological programme that involves the activation of both angiogenesis and immunosuppressive responses, often through the same cell types or soluble factors. We suggest that the (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249972 Fri, 23 Sep 2011 04:00:00 +0100 5249972 Highlights of 10 years of immunology in Nature Reviews Immunology http://www.medworm.com/index.php?rid=5249971&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FsKa5CE14Alw%2Fnri3063 Authors: Ruslan Medzhitov, Ethan M. Shevach, Giorgio Trinchieri, Andrew L. Mellor, David H. Munn, Siamon Gordon, Peter Libby, Göran K. Hansson, Ken Shortman, Chen Dong, Dmitry Gabrilovich, Leona Gabryšová, Ashleigh Howes & Anne O'Garra As Nature Reviews Immunology reaches its 10th anniversary, the authors of one of the top-cited articles from each year take a trip down memory lane. We've asked them to look back on the state of research at the time their Review was (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249971 Fri, 23 Sep 2011 04:00:00 +0100 5249971 Organ-specific features of natural killer cells http://www.medworm.com/index.php?rid=5249968&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FXmsX8L6MFng%2Fnri3065 Authors: Fu-Dong Shi, Hans-Gustaf Ljunggren, Antonio La Cava & Luc Van Kaer Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals at target organs of disease. However, the role of NK cells in mounting inflammatory responses is often complex and sometimes paradoxical. Here, we examine the divergent phenotypic and (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249968 Fri, 23 Sep 2011 04:00:00 +0100 5249968 Allergy: Peaceful death ends pain http://www.medworm.com/index.php?rid=5249964&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F5vD4PKUKiQI%2Fnri3076 Nature Reviews Immunology 11, 643 (2011). doi:10.1038/nri3076 Author: Yvonne Bordon Tolerogenic DCs kill effector CD8+ T cells and inhibit allergic reactions in the skin. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249964 Fri, 23 Sep 2011 04:00:00 +0100 5249964 Natural killer T cells: Worth holding on to http://www.medworm.com/index.php?rid=5249963&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F-uXfLZWlrZM%2Fnri3075 Nature Reviews Immunology 11, 642 (2011). doi:10.1038/nri3075 Author: Yvonne Bordon Invariant NKT cells recognize glycoproteins from Streptococcus species and promote immunity to these bacteria. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249963 Fri, 23 Sep 2011 04:00:00 +0100 5249963 In Brief http://www.medworm.com/index.php?rid=5249961&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FdBFULHUYAbM%2Fnri3083 This study shows that pulmonary endothelial cells can negatively regulate both immune cell infiltration (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249961 Fri, 23 Sep 2011 04:00:00 +0100 5249961 Tumour immunology: Neutrophils fight back in the final round http://www.medworm.com/index.php?rid=5249960&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FwFmZZfJ6xrU%2Fnri3081 Nature Reviews Immunology 11, 640 (2011). doi:10.1038/nri3081 Author: Kirsty Minton Neutrophil activation in the pre-metastatic niche can inhibit tumour cell seeding. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249960 Fri, 23 Sep 2011 04:00:00 +0100 5249960 Virus-hunter gatherers http://www.medworm.com/index.php?rid=5249958&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FsGKNOhyHLMU%2Fnri3080 Nature Reviews Immunology 11, 640 (2011). doi:10.1038/nri3080 Author: Yvonne Bordon They may have met during an ice age but relations between early humans and their evolutionary cousins were anything but frosty. It seems that humans acquired MHC class I genes by mating with Neanderthals and another ancient people, the Denisovans.Researchers led by Peter Parham (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249958 Fri, 23 Sep 2011 04:00:00 +0100 5249958 In Brief http://www.medworm.com/index.php?rid=5249957&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FlYW0PKiVPpU%2Fnri3082 Nature Reviews Immunology 11, 639 (2011). doi:10.1038/nri3082 InfectionInflammatory dendritic cells migrate in and out of transplanted chronic mycobacterial granulomas in miceSchreiber, H. A.et al. J. Clin. Invest.12 Sep 2011 (doi:10.1172/JCI45113)During infection with Mycobacterium tuberculosis, host granulomas prevent bacterial dissemination, but little (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249957 Fri, 23 Sep 2011 04:00:00 +0100 5249957 Phagocytosis: Phagocytes whet their appetite http://www.medworm.com/index.php?rid=5249956&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fds1VfuQQhXM%2Fnri3078 Nature Reviews Immunology 11, 639 (2011). doi:10.1038/nri3078 Author: Rachel David Mitochondrial membrane potential regulates a cell's phagocytic ability. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249956 Fri, 23 Sep 2011 04:00:00 +0100 5249956 Immunotherapy: Leukadherins get a grip on inflammation http://www.medworm.com/index.php?rid=5249955&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FRVXf_DIGS-I%2Fnri3079 Nature Reviews Immunology 11, 638 (2011). doi:10.1038/nri3079 Author: Yvonne Bordon New drugs promoting integrin activation stop inflammatory cells from moving on. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249955 Fri, 23 Sep 2011 04:00:00 +0100 5249955 Turning 10 http://www.medworm.com/index.php?rid=5249953&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FAL9IVhXVgEY%2Fnri3072 Nature Reviews Immunology 11, 635 (2011). doi:10.1038/nri3072 Nature Reviews Immunology celebrates it 10th birthday this month, which provides an opportunity for us to take stock of the advances in the field of immunology over the past decade and to consider what the future might hold. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249953 Fri, 23 Sep 2011 04:00:00 +0100 5249953 In this issue http://www.medworm.com/index.php?rid=5249952&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FhoFBiEok3Ig%2Fnri3077 Nature Reviews Immunology 11, 633 (2011). doi:10.1038/nri3077 It's our birthday! Yes, Nature Reviews Immunology is 10 years old this month and, to thank our readers and authors for their incredible support over the years, we have lined up a very special issue for you. In our featured Viewpoint article on page (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249952 Fri, 23 Sep 2011 04:00:00 +0100 5249952 B cells: WASP stings autoreactive B cells http://www.medworm.com/index.php?rid=5249962&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FDQT2CsZRnQA%2Fnri3074 Nature Reviews Immunology 11, 642 (2011). doi:10.1038/nri3074 Author: Maria Papatriantafyllou Hyperresponsive WASP-deficient B cells depend on T cells to mediate autoimmunity. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249962 Fri, 16 Sep 2011 04:00:00 +0100 5249962 Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response http://www.medworm.com/index.php?rid=5249970&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FRLLoyepbOOQ%2Fnri3062 Authors: Katherine Y. King & Margaret A. Goodell Cells of the innate and adaptive immune systems are the progeny of a variety of haematopoietic precursors, the most primitive of which is the haematopoietic stem cell. Haematopoietic stem cells have been thought of generally as dormant cells that are only called upon to divide (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249970 Fri, 09 Sep 2011 04:00:00 +0100 5249970 New insights into the T cell synapse from single molecule techniques http://www.medworm.com/index.php?rid=5249969&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FfYGGlc8RVsg%2Fnri3066 Authors: Michael L. Dustin & David Depoil T cell activation depends on extracellular ligation of the T cell receptor (TCR) by peptide–MHC complexes in a synapse between the T cell and an antigen-presenting cell. The process then requires the assembly of signalling complexes between the TCR and the adaptor protein linker for (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249969 Fri, 09 Sep 2011 04:00:00 +0100 5249969 Inflammasome: NAIPs: pathogen-sensing proteins http://www.medworm.com/index.php?rid=5249966&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FDgNxEhW-8Do%2Fnri3069 Nature Reviews Immunology 11, 644 (2011). doi:10.1038/nri3069 Author: Olive Leavy NAIP family members mediate NLRC4 inflammasome activation in response to distinct bacterial ligands. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249966 Fri, 09 Sep 2011 04:00:00 +0100 5249966 Trafficking: Tracking immune cells on the lymph node map http://www.medworm.com/index.php?rid=5249965&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FPpJSYaKUbjw%2Fnri3068 Nature Reviews Immunology 11, 644 (2011). doi:10.1038/nri3068 Author: Maria Papatriantafyllou Combining intralymphatic microinjection with imaging technologies helps to trace DC and T cell routes in the lymph nodes. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249965 Fri, 09 Sep 2011 04:00:00 +0100 5249965 Cytokines: Structuring the type I IFN response http://www.medworm.com/index.php?rid=5249959&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FxiN7zmUFnKM%2Fnri3067 Nature Reviews Immunology 11, 640 (2011). doi:10.1038/nri3067 Author: Olive Leavy Binding affinity determines the biological activities of type I interferons. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249959 Mon, 05 Sep 2011 04:00:00 +0100 5249959 NK cell development, homeostasis and function: parallels with CD8+ T cells http://www.medworm.com/index.php?rid=5249967&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FYpdY3sG8RlQ%2Fnri3044 Authors: Joseph C. Sun & Lewis L. Lanier Natural killer (NK) cells survey host tissues for signs of infection, transformation or stress and, true to their name, kill target cells that have become useless or are detrimental to the host. For decades, NK cells have been classified as a component of the innate (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249967 Fri, 26 Aug 2011 04:00:00 +0100 5249967 The gut microbiota: challenging immunology http://www.medworm.com/index.php?rid=5249954&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FVdDY5ngXstM%2Fnri3061 Authors: Navkiran Gill & B. Brett Finlay For several decades the intestinal microbiota was mainly studied by those investigating infections and diseases associated with gut health, usually from a microbiology point of view. In the past few years, however, it has become apparent that the intestinal microbiota has widespread implications in the (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5249954 Fri, 26 Aug 2011 04:00:00 +0100 5249954 Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease? http://www.medworm.com/index.php?rid=5160588&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F5W-QqAfR4dg%2Fnri3043 Authors: Caroline Jefferies, Claire Wynne & Rowan Higgs The concept that viral sensing systems, via their ability to drive pro-inflammatory cytokine and interferon production, contribute to the development of autoimmune and autoinflammatory disease is supported by a wide range of clinical and experimental observations. Recently, the tripartite motif-containing proteins (TRIMs) have emerged as (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160588 Wed, 24 Aug 2011 23:00:00 +0100 5160588 Homeostatic chemokine receptors and organ-specific metastasis http://www.medworm.com/index.php?rid=5160586&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FNy-t4gdU1ng%2Fnri3049 Authors: Albert Zlotnik, Amanda M. Burkhardt & Bernhard Homey It has been 10 years since the role of a chemokine receptor, CXCR4, in breast cancer metastasis was first documented. Since then, the field of chemokines and cancer has grown significantly, so it is timely to review the progress, analyse the studies to date and (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160586 Wed, 24 Aug 2011 23:00:00 +0100 5160586 Flu 'super-antibody' http://www.medworm.com/index.php?rid=5160583&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F62ZE7vtAfu0%2Fnri3054 Nature Reviews Immunology 11, 574 (2011). doi:10.1038/nri3054 Author: Olive Leavy A universal influenza vaccine has been something of a holy grail for vaccinologists, but the recent isolation of a neutralizing antibody that recognizes a conserved portion of the haemagglutinin glycoprotein of all 16 subtypes and neutralizes both group 1 and group 2 influenza A viruses (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160583 Wed, 24 Aug 2011 23:00:00 +0100 5160583 Immune regulation: (micro)Control of IFNγ http://www.medworm.com/index.php?rid=5160581&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FdtoL4yyEJ38%2Fnri3052 Nature Reviews Immunology 11, 573 (2011). doi:10.1038/nri3052 Author: Olive Leavy The microRNA miR-29 suppresses IFNγ production. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160581 Wed, 24 Aug 2011 23:00:00 +0100 5160581 Regulatory T cells: Pursuing a germinal centre career http://www.medworm.com/index.php?rid=5160580&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FFAmgbQ31658%2Fnri3053 Nature Reviews Immunology 11, 572 (2011). doi:10.1038/nri3053 Author: Maria Papatriantafyllou TReg cells expressing CXCR5 and BCL-6 regulate germinal centre responses. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160580 Wed, 24 Aug 2011 23:00:00 +0100 5160580 In Brief http://www.medworm.com/index.php?rid=5160578&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FurqHafNF11E%2Fnri3059 This study characterizes a dendritic cell (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160578 Wed, 24 Aug 2011 23:00:00 +0100 5160578 MHC molecules: Cod's wallop? It's first class! http://www.medworm.com/index.php?rid=5160577&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fa6WmnlgJIC4%2Fnri3060 Nature Reviews Immunology 11, 570 (2011). doi:10.1038/nri3060 Author: Yvonne Bordon Atlantic cod have no MHC class II molecules but encode additional MHC class I molecules and a unique TLR repertoire. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160577 Wed, 24 Aug 2011 23:00:00 +0100 5160577 Immune regulation: Worming away from TB immunity http://www.medworm.com/index.php?rid=5160575&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FZhbXG2PNsaE%2Fnri3056 Nature Reviews Immunology 11, 570 (2011). doi:10.1038/nri3056 Author: Olive Leavy Helminth infection prevents anti-tuberculosis immunity via the induction of pulmonary alternatively activated macrophages. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160575 Wed, 24 Aug 2011 23:00:00 +0100 5160575 In Brief http://www.medworm.com/index.php?rid=5160574&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FD64dVgH-u9g%2Fnri3058 Nature Reviews Immunology 11, 569 (2011). doi:10.1038/nri3058 ImmunogeneticsGenetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosisThe International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2. Nature476, 214–219 (2011)The results from the most extensive genome-wide (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160574 Wed, 24 Aug 2011 23:00:00 +0100 5160574 Innate immunity: AT-rich DNA trapped in the cytoplasm http://www.medworm.com/index.php?rid=5160573&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fj-_ZxJSHoIU%2Fnri3057 Nature Reviews Immunology 11, 569 (2011). doi:10.1038/nri3057 Author: Maria Papatriantafyllou AT-rich DNA induces the expression of type I IFNs through an unknown cytoplasmic DNA sensor. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160573 Wed, 24 Aug 2011 23:00:00 +0100 5160573 From the editors http://www.medworm.com/index.php?rid=5160571&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FWCFc95G8ffM%2Fnri3055 Nature Reviews Immunology 11, 567 (2011). doi:10.1038/nri3055 Susceptibility to disease is controlled by a combination of genetic and environmental factors that affect the function of the immune system. One such genetic association is illustrated by dendritic cell (DC) deficiency, which increases susceptibility to intracellular infections. Matthew Collin and colleagues, on page 575 (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160571 Wed, 24 Aug 2011 23:00:00 +0100 5160571 Modulation of the immune system by UV radiation: more than just the effects of vitamin D? http://www.medworm.com/index.php?rid=5160585&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FHPHnEKbzm2s%2Fnri3045 Authors: Prue H. Hart, Shelley Gorman & John J. Finlay-Jones Humans obtain most of their vitamin D through the exposure of skin to sunlight. The immunoregulatory properties of vitamin D have been demonstrated in studies showing that vitamin D deficiency is associated with poor immune function and increased disease susceptibility. The benefits of moderate ultraviolet (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160585 Thu, 18 Aug 2011 23:00:00 +0100 5160585 Human dendritic cell deficiency: the missing ID? http://www.medworm.com/index.php?rid=5160584&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FvTvc5BtbWIk%2Fnri3046 Authors: Matthew Collin, Venetia Bigley, Muzlifah Haniffa & Sophie Hambleton Animal models and human in vitro systems indicate that dendritic cells (DCs) have a crucial role in priming naive T cells, but just how important are they in the intact human? Recent descriptions of human DC deficiency have begun to shed light on this (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160584 Thu, 18 Aug 2011 23:00:00 +0100 5160584 Inflammation: A gutsy repair job http://www.medworm.com/index.php?rid=5160582&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FIhCMhXaUC-Q%2Fnri3051 Nature Reviews Immunology 11, 574 (2011). doi:10.1038/nri3051 Author: Kirsty Minton T cell-independent function of TSLP in the resolution of colitis. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160582 Thu, 11 Aug 2011 23:00:00 +0100 5160582 Innate immunity: MAVS build-ups for defence http://www.medworm.com/index.php?rid=5160576&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FKCgOf8Ms8ko%2Fnri3050 Nature Reviews Immunology 11, 570 (2011). doi:10.1038/nri3050 Author: Maria Papatriantafyllou Prion-like MAVS aggregates trigger the antiviral immune response. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160576 Thu, 11 Aug 2011 23:00:00 +0100 5160576 Reciprocal regulation of the neural and innate immune systems http://www.medworm.com/index.php?rid=5160589&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fwc8XoffcajA%2Fnri3042 Authors: Michael R. Irwin & Steven W. Cole Innate immune responses are regulated by microorganisms and cell death, as well as by a third class of stress signal from the nervous and endocrine systems. The innate immune system also feeds back, through the production of cytokines, to regulate the function of the central (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160589 Thu, 04 Aug 2011 23:00:00 +0100 5160589 The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease http://www.medworm.com/index.php?rid=5160587&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FG4zvhlNA0Bo%2Fnri3041 Authors: Michael Gleeson, Nicolette C. Bishop, David J. Stensel, Martin R. Lindley, Sarabjit S. Mastana & Myra A. Nimmo Regular exercise reduces the risk of chronic metabolic and cardiorespiratory diseases, in part because exercise exerts anti-inflammatory effects. However, these effects are also likely to be responsible for the suppressed immunity that makes elite athletes more susceptible to infections. The anti-inflammatory effects of regular exercise (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160587 Thu, 04 Aug 2011 23:00:00 +0100 5160587 T cells: mTOR lullabies for naive T cells http://www.medworm.com/index.php?rid=5160579&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FSgFzTBRufsc%2Fnri3047 Nature Reviews Immunology 11, 572 (2011). doi:10.1038/nri3047 Author: Maria Papatriantafyllou TSC1 maintains naive T cell quiescence through inhibition of mTORC1 activity. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160579 Thu, 04 Aug 2011 23:00:00 +0100 5160579 T cell responses: Anger management for TH17 cells http://www.medworm.com/index.php?rid=5160572&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FIMe4bjODO_c%2Fnri3048 Nature Reviews Immunology 11, 568 (2011). doi:10.1038/nri3048 Author: Yvonne Bordon Peripheral TH17 cells can acquire regulatory functions in the small intestine. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5160572 Thu, 04 Aug 2011 23:00:00 +0100 5160572 TH17 cells in tumour immunity and immunotherapy http://www.medworm.com/index.php?rid=5063041&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FKYP9PRS1vuM%2Fnri3029 Nature Reviews Immunology 11, 565 (2011). doi:10.1038/nri3029 Author: Weiping Zou & Nicholas P. Restifo Nature Reviews Immunology10, 248–256 (2010)In the original version of this article, in the section under the subheading “IL-17 and TH17 cells” on page 252, the sentence that began “Furthermore, although IL-17 deficiency leads to increased (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063041 Sun, 24 Jul 2011 23:00:00 +0100 5063041 Are heat shock proteins DAMPs? http://www.medworm.com/index.php?rid=5063040&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F2exBEdkmWHU%2Fnri2873-c2 Authors: Grace Y. Chen & Gabriel Nuñez We discuss below the correspondence relating to our Review article (Sterile inflammation: sensing and reacting to damage. Nature Rev. Immunol.10, 826–837 (2010)) by Willem van Eden and colleagues (Heat shock proteins are no DAMPs, rather 'DAMPERs'. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063040 Sun, 24 Jul 2011 23:00:00 +0100 5063040 Heat shock proteins are no DAMPs, rather 'DAMPERs' http://www.medworm.com/index.php?rid=5063039&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fbdj6bfrmV4E%2Fnri2873-c1 Authors: Femke Broere, Ruurd van der Zee & Willem van Eden Originally, the immune system was seen as a system that primarily combats infection. But, as discussed in the recent Review article by Grace Chen and Gabriel Nuñez (Sterile inflammation: sensing and reacting to damage. Nature Rev. Immunol.10, 826–837 (2010 (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063039 Sun, 24 Jul 2011 23:00:00 +0100 5063039 Neutrophils in the activation and regulation of innate and adaptive immunity http://www.medworm.com/index.php?rid=5063034&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FAMinzSJ6Jok%2Fnri3024 Authors: Alberto Mantovani, Marco A. Cassatella, Claudio Costantini & Sébastien Jaillon Neutrophils have long been viewed as the final effector cells of an acute inflammatory response, with a primary role in the clearance of extracellular pathogens. However, more recent evidence has extended the functions of these cells. The newly discovered repertoire of effector molecules in the (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063034 Sun, 24 Jul 2011 23:00:00 +0100 5063034 In Brief http://www.medworm.com/index.php?rid=5063032&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F2sJ0e7FARNs%2Fnri3039 This study describes a mechanism for the negative regulation of innate immune responses to pathogens in (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063032 Sun, 24 Jul 2011 23:00:00 +0100 5063032 T cells: A metabolic sHIFt to turn 17 http://www.medworm.com/index.php?rid=5063030&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FEMFAygC3_7Q%2Fnri3037 Nature Reviews Immunology 11, 503 (2011). doi:10.1038/nri3037 Author: Isabel Woodman A HIF1α-dependent metabolic switch influences the balance between TH17 and induced TReg cell differentiation. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063030 Sun, 24 Jul 2011 23:00:00 +0100 5063030 Innate immunity: SHP regulates TLR signalling http://www.medworm.com/index.php?rid=5063028&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FUEg3QE-pZdU%2Fnri3031 Nature Reviews Immunology 11, 502 (2011). doi:10.1038/nri3031 Author: Olive Leavy SHP is a negative regulator of TLR signalling pathways. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063028 Sun, 24 Jul 2011 23:00:00 +0100 5063028 B cells: The B boyz of sepsis http://www.medworm.com/index.php?rid=5063027&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FbKutd8lga64%2Fnri3036 Nature Reviews Immunology 11, 501 (2011). doi:10.1038/nri3036 Author: Olive Leavy B cells help protect against sepsis-induced lethality. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063027 Sun, 24 Jul 2011 23:00:00 +0100 5063027 In the news http://www.medworm.com/index.php?rid=5063024&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FgmrBh77rjWs%2Fnri3040 Nature Reviews Immunology 11, 500 (2011). doi:10.1038/nri3040 Author: Olive Leavy The pain of sunburnIf you have ever suffered from sunburn, you know that it hurts. Now, researchers at King's College London, UK, have discovered that CXC-chemokine ligand 5 (CXCL5) mediates sensitivity to ultraviolet B (UVB)-induced pain and that blocking this chemokine has an analgesic (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063024 Sun, 24 Jul 2011 23:00:00 +0100 5063024 In Brief http://www.medworm.com/index.php?rid=5063023&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FnVi8oM8OpmU%2Fnri3033 Nature Reviews Immunology 11, 499 (2011). doi:10.1038/nri3033 Cell death and immunityPerforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cellsThiery, J.et al. Nature Immunol.19 Jun 2011 (doi:10.1038/ni.2050)Cytotoxic lymphocytes use the pore-forming protein perforin (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063023 Sun, 24 Jul 2011 23:00:00 +0100 5063023 From the editors http://www.medworm.com/index.php?rid=5063020&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FuDV_YKSlwbM%2Fnri3038 Nature Reviews Immunology 11, 497 (2011). doi:10.1038/nri3038 Welcome to the August issue of Nature Reviews Immunology. Immunologists use a number of techniques to gather information on their topics of interest. One of the best methods that exists for 'spying' on immune cells is the use of peptide–MHC multimers to track rare, (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063020 Sun, 24 Jul 2011 23:00:00 +0100 5063020 Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? http://www.medworm.com/index.php?rid=5063038&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FWbqkij37WpQ%2Fnri3027 Authors: Boris Reizis, Marco Colonna, Giorgio Trinchieri, Franck Barrat & Michel Gilliet Plasmacytoid dendritic cells (pDCs) were first described as interferon-producing cells and, for many years, their overlapping characteristics with both lymphocytes and classical dendritic cells (cDCs) created confusion over their exact ontogeny. In this Viewpoint article, Nature Reviews Immunology asks five leaders in the field (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063038 Thu, 21 Jul 2011 23:00:00 +0100 5063038 Post-thymic maturation: young T cells assert their individuality http://www.medworm.com/index.php?rid=5063036&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FI5uYyGpZbv0%2Fnri3028 Authors: Pamela J. Fink & Deborah W. Hendricks T cell maturation was once thought to occur entirely within the thymus. Now, evidence is mounting that the youngest peripheral T cells in both mice and humans comprise a distinct population from their more mature, yet still naive, counterparts. These cells, termed recent thymic emigrants (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063036 Thu, 21 Jul 2011 23:00:00 +0100 5063036 Immune regulation: Lysosomes at the heart of inflammation http://www.medworm.com/index.php?rid=5063029&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fe-4tMPGm8VQ%2Fnri3035 Nature Reviews Immunology 11, 502 (2011). doi:10.1038/nri3035 Author: Yvonne Bordon Lysosomes promote inflammation by degrading cytosolic glucocorticoid receptors. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063029 Thu, 21 Jul 2011 23:00:00 +0100 5063029 Asthma: The secret face of H. pylori http://www.medworm.com/index.php?rid=5063026&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FkvrAcQm0MBI%2Fnri3034 Nature Reviews Immunology 11, 500 (2011). doi:10.1038/nri3034 Author: Maria Papatriantafyllou Early infection with H. pylori prevents asthma in a TReg cell-dependent manner. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063026 Thu, 21 Jul 2011 23:00:00 +0100 5063026 Tolerance: Both natural and induced TReg talents needed http://www.medworm.com/index.php?rid=5063025&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FTc9IpMG_RB4%2Fnri3030 Nature Reviews Immunology 11, 500 (2011). doi:10.1038/nri3030 Author: Maria Papatriantafyllou Induced CD4+ TReg cells are essential for tolerance even in the presence of natural TReg cells. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063025 Thu, 21 Jul 2011 23:00:00 +0100 5063025 Innate immunity: Neutrophil U-turn fans the flames http://www.medworm.com/index.php?rid=5063021&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F4C7lbQqs9_I%2Fnri3032 Nature Reviews Immunology 11, 498 (2011). doi:10.1038/nri3032 Author: Yvonne Bordon Backtracking neutrophils can promote dissemination of inflammatory responses. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063021 Thu, 21 Jul 2011 23:00:00 +0100 5063021 Interrogating the repertoire: broadening the scope of peptide–MHC multimer analysis http://www.medworm.com/index.php?rid=5063037&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F7NL4O5c4XWc%2Fnri3020 Authors: Mark M. Davis, John D. Altman & Evan W. Newell Labelling antigen-specific T cells with peptide–MHC multimers has provided an invaluable way to monitor T cell-mediated immune responses. A number of recent developments in this technology have made these multimers much easier to make and use in large numbers. Furthermore, enrichment techniques have provided a (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063037 Thu, 14 Jul 2011 23:00:00 +0100 5063037 Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms http://www.medworm.com/index.php?rid=5063035&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2Fm0gzIcTRJXs%2Fnri3014 Nature Reviews Immunology 11, 532 (2011). doi:10.1038/nri3014 Author: Alan L. Rothman Dengue is a mosquito-borne viral disease of expanding geographical range and incidence. The existence of four viral serotypes and the association of prior dengue virus infection with an increased risk for more severe disease have presented significant obstacles to vaccine development. An increased understanding of (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063035 Thu, 14 Jul 2011 23:00:00 +0100 5063035 Antiviral immunity: Rapid response team http://www.medworm.com/index.php?rid=5063031&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F_gmiwgrn7OI%2Fnri3025 Nature Reviews Immunology 11, 504 (2011). doi:10.1038/nri3025 Author: Kirsty Minton A helicase–TRIF complex functions as a 'first responder' to viral dsRNA that triggers initial interferon production. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063031 Thu, 07 Jul 2011 23:00:00 +0100 5063031 Immunotherapy: Pieces of the IVIG anti-inflammatory response http://www.medworm.com/index.php?rid=5063022&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FSiV89sYWDJM%2Fnri3026 Nature Reviews Immunology 11, 499 (2011). doi:10.1038/nri3026 Author: Maria Papatriantafyllou IVIG-mediated immunosuppression occurs through IL-33-induced expansion of IL-4-secreting basophil populations. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063022 Thu, 07 Jul 2011 23:00:00 +0100 5063022 Immunity against Staphylococcus aureus cutaneous infections http://www.medworm.com/index.php?rid=5063033&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FzoVQf5Zf0wM%2Fnri3010 Authors: Lloyd S. Miller & John S. Cho Complications arising from cutaneous and soft tissue infections with Staphylococcus aureus are a major clinical problem owing to the high incidence of these infections and the widespread emergence of antibiotic-resistant bacterial strains. If prophylactic vaccines or immunotherapy for certain patient populations are to be (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=5063033 Thu, 30 Jun 2011 23:00:00 +0100 5063033 Signal integration and crosstalk during thymocyte migration and emigration http://www.medworm.com/index.php?rid=4969554&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FBYSSAzhLXOA%2Fnri2989 Authors: Paul E. Love & Avinash Bhandoola The thymus produces self-tolerant functionally competent T cells. This process involves the import of multipotent haematopoietic progenitors that are then signalled to adopt the T cell fate. Expression of T cell-specific genes, including those encoding the T cell receptor (TCR), is followed by positive and (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=4969554 Thu, 23 Jun 2011 23:00:00 +0100 4969554 In the news http://www.medworm.com/index.php?rid=4969551&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FlwBdd2AYZ0E%2Fnri3021 Nature Reviews Immunology 11, 444 (2011). doi:10.1038/nri3021 Author: Kirsty Minton Vaccine valueAt the first pledging conference held by the Global Alliance for Vaccines and Immunisation (GAVI) in London on 13 June 2011, donors pledged a total of $4.3 billion of new funds to help immunize 243 million more children in 72 countries (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=4969551 Thu, 23 Jun 2011 23:00:00 +0100 4969551 Macrophages: Support from the locals http://www.medworm.com/index.php?rid=4969548&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FZH_ioiR26zk%2Fnri3016 Nature Reviews Immunology 11, 442 (2011). doi:10.1038/nri3016 Author: Maria Papatriantafyllou Proliferation of tissue-resident macrophages, rather than recruitment of blood macrophages, marks helminth infection. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=4969548 Thu, 23 Jun 2011 23:00:00 +0100 4969548 In Brief http://www.medworm.com/index.php?rid=4969546&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FzvSTdqZ-yjo%2Fnri3022 Nature Reviews Immunology 11, 441 (2011). doi:10.1038/nri3022 Tumour immunologyB regulatory cells and the tumor-promoting actions of TNF-α during squamous carcinogenesisSchioppa, T.et al. Proc. Natl Acad. Sci. USA13 Jun 2011 (doi:10.1073/pnas.1100994108)Tumour necrosis factor (TNF) is involved in the promotion and progression of various (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=4969546 Thu, 23 Jun 2011 23:00:00 +0100 4969546 Tumour immunology: MDSCs come at a cost http://www.medworm.com/index.php?rid=4969545&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F9q2W3VA0wik%2Fnri3017 Nature Reviews Immunology 11, 440 (2011). doi:10.1038/nri3017 Author: Maria Papatriantafyllou Increased numbers and suppressive activity of MDSCs during pregnancy results in reduced NK cell cytotoxicity and increased tumour dissemination. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=4969545 Thu, 23 Jun 2011 23:00:00 +0100 4969545 Antiviral immunity: SAMHD1 — stopping HIV in its tracks http://www.medworm.com/index.php?rid=4969543&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2F9k8qXKiDGfs%2Fnri3018 Nature Reviews Immunology 11, 440 (2011). doi:10.1038/nri3018 Author: Olive Leavy SAMHD1 is a HIV-1 restriction factor expressed by myeloid cells. (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=4969543 Thu, 23 Jun 2011 23:00:00 +0100 4969543 In Brief http://www.medworm.com/index.php?rid=4969542&cid=s_33190_3_f&fid=33190&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnri%2Frss%2Fcurrent%2F%7E3%2FCVtsrI75Aio%2Fnri3023 Nature Reviews Immunology 11, 439 (2011). doi:10.1038/nri3023 Mucosal immunologyThe Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiotaRound, J. L.et al. Science332, 974–977 (2011)Why does colonization by non-pathogenic bacteria not elicit pro-inflammatory T cell responses? (Source: Nature Reviews Immunology) Nature Reviews Immunology journals http://www.medworm.com/rss/comments.php?id=4969542 Thu, 23 Jun 2011 23:00:00 +0100 4969542