MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nature Reviews Molecular Cell Biology' source. Sat, 20 Mar 2010 16:35:38 +0100 http://www.medworm.com/index.php?rid=3298168&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FLlPdkCi9RVE%2Fnrm2865 Nature Reviews Molecular Cell Biology 11, 157 (2010). doi:10.1038/nrm2865 The integrity of the genome is crucial for tumour suppression and the propagation of genomic information. DNA damage can result from cellular metabolism, routine errors in DNA replication and recombination, and exogenous genotoxic agents. To combat these attacks, cells have evolved a response system that (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298168 Tue, 23 Feb 2010 17:13:21 +0100 3298168 http://www.medworm.com/index.php?rid=3298167&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FPBUlT0ubvc4%2Fnrm2864 Nature Reviews Molecular Cell Biology 11, 161 (2010). doi:10.1038/nrm2864 Author: Maria Hodges The SUMO E1 active site is remodelled for thioester bond formation. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298167 Tue, 23 Feb 2010 17:13:21 +0100 3298167 http://www.medworm.com/index.php?rid=3298166&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FaUpyZGPH3ns%2Fnrm2863 Nature Reviews Molecular Cell Biology 11, 161 (2010). doi:10.1038/nrm2863 Genome instability (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298166 Tue, 23 Feb 2010 17:13:21 +0100 3298166 http://www.medworm.com/index.php?rid=3298165&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FTXkmgPDyTd4%2Fnrm2862 Nature Reviews Molecular Cell Biology 11, 163 (2010). doi:10.1038/nrm2862 Author: Kim Baumann Nucleoporins activate developmental and cell cycle genes in D. melanogaster. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298165 Tue, 23 Feb 2010 17:13:21 +0100 3298165 http://www.medworm.com/index.php?rid=3298164&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FIqaxHRwPCb8%2Fnrm2860 Cell signalling: TMEPAI keeps TGFβ under control Nature Reviews Molecular Cell Biology 11, 162 (2010). doi:10.1038/nrm2860 Author: Katharine H. Wrighton The TGFβ-induced protein TMEPAI negatively regulates TGFβ signalling. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298164 Tue, 23 Feb 2010 17:13:21 +0100 3298164 http://www.medworm.com/index.php?rid=3298163&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F4QbirVH3ces%2Fnrm2858 Genomic instability — an evolving hallmark of cancer Nature Reviews Molecular Cell Biology 11, 220 (2010). doi:10.1038/nrm2858 Authors: Simona Negrini, Vassilis G. Gorgoulis & Thanos D. Halazonetis Genomic instability is a characteristic of most cancers. In hereditary cancers, genomic instability results from mutations in DNA repair genes and drives cancer development, as predicted by the mutator hypothesis. In sporadic (non-hereditary) cancers the molecular basis of genomic instability remains unclear, but recent high-throughput (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298163 Tue, 23 Feb 2010 17:13:21 +0100 3298163 http://www.medworm.com/index.php?rid=3298162&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FHy_bPZYi6l4%2Fnrm2854 Authors: Arturo López Castel, John D. Cleary & Christopher E. Pearson Expansions of repetitive DNA sequences cause numerous human neurological and neuromuscular diseases. Ongoing repeat expansions in patients can exacerbate disease progression and severity. As pathogenesis is connected to repeat length, a potential therapeutic avenue is to modulate disease by manipulating repeat expansion size — targeting (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298162 Tue, 23 Feb 2010 17:13:21 +0100 3298162 http://www.medworm.com/index.php?rid=3298161&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FOX1i6en3DMU%2Fnrm2852 Authors: Dana Branzei & Marco Foiani Aberrant DNA replication is a major source of the mutations and chromosome rearrangements that are associated with pathological disorders. When replication is compromised, DNA becomes more prone to breakage. Secondary structures, highly transcribed DNA sequences and damaged DNA stall replication forks, which then require checkpoint (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298161 Tue, 23 Feb 2010 17:13:21 +0100 3298161 http://www.medworm.com/index.php?rid=3298160&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FNKpEFtayAHc%2Fnrm2851 Authors: Mary Ellen Moynahan & Maria Jasin Mitotic homologous recombination promotes genome stability through the precise repair of DNA double-strand breaks and other lesions that are encountered during normal cellular metabolism and from exogenous insults. As a result, homologous recombination repair is essential during proliferative stages in development and during somatic cell (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298160 Tue, 23 Feb 2010 17:13:21 +0100 3298160 http://www.medworm.com/index.php?rid=3298159&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FW0fFKhEamNY%2Fnrm2859 Nature Reviews Molecular Cell Biology 11, 162 (2010). doi:10.1038/nrm2859 Author: Francesca Cesari Histone marks regulate alternative splicing. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298159 Thu, 18 Feb 2010 00:00:00 +0100 3298159 http://www.medworm.com/index.php?rid=3298158&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FzN5QT3nAF3g%2Fnrm2857 Nature Reviews Molecular Cell Biology 11, 160 (2010). doi:10.1038/nrm2857 Author: Rachel David Ribosomal DNA repeats are essential for maintaining genome integrity. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298158 Thu, 18 Feb 2010 00:00:00 +0100 3298158 http://www.medworm.com/index.php?rid=3298157&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FxPJBnk6_zF4%2Fnrm2849 Authors: Mariko Sasaki, Julian Lange & Scott Keeney Meiotic recombination, which promotes proper homologous chromosome segregation at the first meiotic division, normally occurs between allelic sequences on homologues. However, recombination can also take place between non-allelic DNA segments that share high sequence identity. Such non-allelic homologous recombination (NAHR) can markedly alter genome architecture (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298157 Thu, 18 Feb 2010 00:00:00 +0100 3298157 http://www.medworm.com/index.php?rid=3298156&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FLtJdMYQ5aNQ%2Fnrm2856 Nature Reviews Molecular Cell Biology 11, 164 (2010). doi:10.1038/nrm2856 Author: Kim Baumann Integrin–Gα13 interaction mediates signalling to SRC and RHOA. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298156 Wed, 10 Feb 2010 00:00:00 +0100 3298156 http://www.medworm.com/index.php?rid=3298155&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FZ9z8Hb_ud5A%2Fnrm2855 Nature Reviews Molecular Cell Biology 11, 164 (2010). doi:10.1038/nrm2855 Author: Ralph Scully Discovery that radiation induces phosphorylation of histone H2AX. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298155 Wed, 10 Feb 2010 00:00:00 +0100 3298155 http://www.medworm.com/index.php?rid=3298154&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fampr0AX2Hkg%2Fnrm2853 Nature Reviews Molecular Cell Biology 11, 159 (2010). doi:10.1038/nrm2853 Author: Katharine H. Wrighton New insight into how Bub1 and BUBR1 prevent chromosomal instability. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298154 Wed, 10 Feb 2010 00:00:00 +0100 3298154 http://www.medworm.com/index.php?rid=3298153&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FOCMd0dmlDdY%2Fnrm2850 Nature Reviews Molecular Cell Biology 11, 160 (2010). doi:10.1038/nrm2850 Author: Debbie Walker The COG complex directly participates in double-membrane vesicle formation. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298153 Wed, 03 Feb 2010 00:00:00 +0100 3298153 http://www.medworm.com/index.php?rid=3298152&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fith5-j-0ea0%2Fnrm2848 Authors: Roderick J. O'Sullivan & Jan Karlseder The natural ends of linear chromosomes require unique genetic and structural adaptations to facilitate the protection of genetic material. This is achieved by the sequestration of the telomeric sequence into a protective nucleoprotein cap that masks the ends from constitutive exposure to the DNA damage (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3298152 Wed, 03 Feb 2010 00:00:00 +0100 3298152 http://www.medworm.com/index.php?rid=3197485&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fv3ezacM-bgE%2Fnrm2845 Nature Reviews Molecular Cell Biology 11, 89 (2010). doi:10.1038/nrm2845 Transcription (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197485 Fri, 22 Jan 2010 16:48:22 +0100 3197485 http://www.medworm.com/index.php?rid=3197484&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FPAgHOPaUCsI%2Fnrm2846 Nature Reviews Molecular Cell Biology 11, 83 (2010). doi:10.1038/nrm2846 Life is complex, even for a eukaryotic cell. For example, whenever a cell divides and gives rise to two daughter cells, it must faithfully duplicate its genome, ensure that the two resulting genome copies are correctly distributed to the daughter cells and then complete the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197484 Fri, 22 Jan 2010 16:48:22 +0100 3197484 http://www.medworm.com/index.php?rid=3197483&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FYrX-AqK9jQc%2Fnrm2847 Authors: Carine Rosse, Mark Linch, Stéphanie Kermorgant, Angus J. M. Cameron, Katrina Boeckeler & Peter J. Parker Networks of signal transducers determine the conversion of environmental cues into cellular actions. Among the main players in these networks are protein kinases, which can acutely and reversibly modify protein functions to influence cellular events. One group of kinases, the protein kinase C (PKC) family, (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197483 Fri, 22 Jan 2010 16:48:22 +0100 3197483 http://www.medworm.com/index.php?rid=3197482&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FaBhPa8LfliI%2Fnrm2844 Nature Reviews Molecular Cell Biology 11, 86 (2010). doi:10.1038/nrm2844 Author: Nicola McCarthy Mutant p53 promotes cell invasion through integrin recycling. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197482 Fri, 22 Jan 2010 16:48:22 +0100 3197482 http://www.medworm.com/index.php?rid=3197481&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FyookIPjCT0Y%2Fnrm2843 Nature Reviews Molecular Cell Biology 11, 87 (2010). doi:10.1038/nrm2843 Author: Kim Baumann AID and elongator complexes are crucial for mammalian DNA demethylation. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197481 Fri, 22 Jan 2010 16:48:22 +0100 3197481 http://www.medworm.com/index.php?rid=3197480&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FtRR9OwEvrPw%2Fnrm2842 Nature Reviews Molecular Cell Biology 11, 90 (2010). doi:10.1038/nrm2842 Author: Rachel David The Fanconi anaemia protein FANCM links two genome instability disorders. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197480 Fri, 22 Jan 2010 16:48:22 +0100 3197480 http://www.medworm.com/index.php?rid=3197479&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FzgFfXcYjXpc%2Fnrm2841 Nature Reviews Molecular Cell Biology 11, 88 (2010). doi:10.1038/nrm2841 Author: Katharine H. Wrighton miR-8 positively regulates Drosophila melanogaster body size. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197479 Fri, 22 Jan 2010 16:48:22 +0100 3197479 http://www.medworm.com/index.php?rid=3197478&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FQUuSqnqg-d0%2Fnrm2838 Authors: Richard J. Jackson, Christopher U. T. Hellen & Tatyana V. Pestova Protein synthesis is principally regulated at the initiation stage (rather than during elongation or termination), allowing rapid, reversible and spatial control of gene expression. Progress over recent years in determining the structures and activities of initiation factors, and in mapping their interactions in ribosomal initiation (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197478 Fri, 22 Jan 2010 16:48:22 +0100 3197478 http://www.medworm.com/index.php?rid=3197477&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fn852KsPu_YE%2Fnrm2834 Authors: Thomas D. Pollard & Jian-Qiu Wu For decades after the discovery that a contractile ring made of actin filaments and myosin II produces the force to constrict the cleavage furrow of animal cells, the complexity of cytokinesis has slowed progress in understanding the mechanism. Mechanistic insights, however, have been obtained by (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197477 Fri, 22 Jan 2010 16:48:22 +0100 3197477 http://www.medworm.com/index.php?rid=3197476&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fz7PTH9d-DQk%2Fnrm2833 Authors: James A. Spudich & Sivaraj Sivaramakrishnan The swinging crossbridge hypothesis states that energy from ATP hydrolysis is transduced to mechanical movement of the myosin head while bound to actin. The light chain-binding region of myosin is thought to act as a lever arm that amplifies movements near the catalytic site. This (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197476 Fri, 22 Jan 2010 16:48:22 +0100 3197476 http://www.medworm.com/index.php?rid=3197475&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FuJS97VJhNhk%2Fnrm2832 Authors: Claire E. Walczak, Shang Cai & Alexey Khodjakov For over a century, scientists have strived to understand the mechanisms that govern the accurate segregation of chromosomes during mitosis. The most intriguing feature of this process, which is particularly prominent in higher eukaryotes, is the complex behaviour exhibited by the chromosomes. This behaviour is (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197475 Wed, 13 Jan 2010 00:00:00 +0100 3197475 http://www.medworm.com/index.php?rid=3197474&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FwT2WHwTYQT4%2Fnrm2840 Nature Reviews Molecular Cell Biology 11, 86 (2010). doi:10.1038/nrm2840 Author: Emma Leah ORPs bind two membranes simultaneously and regulate sterol transfer between them. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197474 Wed, 13 Jan 2010 00:00:00 +0100 3197474 http://www.medworm.com/index.php?rid=3197473&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FqcNtNRWg1yA%2Fnrm2839 Nature Reviews Molecular Cell Biology 11, 88 (2010). doi:10.1038/nrm2839 Author: Debbie Walker The deacetylase HDAC6 regulates the endocytic trafficking of EGFR. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197473 Wed, 13 Jan 2010 00:00:00 +0100 3197473 http://www.medworm.com/index.php?rid=3197472&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F60bdFab-TaU%2Fnrm2837 Nature Reviews Molecular Cell Biology 11, 88 (2010). doi:10.1038/nrm2837 Author: Francesca Cesari Cell-specific signalling networks during the interaction between cells. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197472 Wed, 13 Jan 2010 00:00:00 +0100 3197472 http://www.medworm.com/index.php?rid=3197471&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FCu_vepaWLP4%2Fnrm2836 Nature Reviews Molecular Cell Biology 11, 90 (2010). doi:10.1038/nrm2836 Author: Olivier Voinnet Understanding the mechanism of siRNA-mediated gene silencing. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197471 Wed, 13 Jan 2010 00:00:00 +0100 3197471 http://www.medworm.com/index.php?rid=3197470&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F99JR1jcoIzA%2Fnrm2835 Nature Reviews Molecular Cell Biology 11, 85 (2010). doi:10.1038/nrm2835 Author: Katharine H. Wrighton PIAS1 and PIAS4 promote BRCA1 sumoylation and DNA repair. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197470 Mon, 04 Jan 2010 00:00:00 +0100 3197470 http://www.medworm.com/index.php?rid=3197469&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FPfr9OshsbxU%2Fnrm2831 Authors: Michael S.Y. Huen, Shirley M.H. Sy & Junjie Chen The breast and ovarian cancer type 1 susceptibility protein (BRCA1) has pivotal roles in the maintenance of genome stability. Studies support that BRCA1 exerts its tumour suppression function primarily through its involvement in cell cycle checkpoint control and DNA damage repair. In addition, recent proteomic (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3197469 Wed, 23 Dec 2009 00:00:00 +0100 3197469 http://www.medworm.com/index.php?rid=3111115&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FrP_lBJw4vjM%2Fnrm2830 Nature Reviews Molecular Cell Biology 11, 7 (2010). doi:10.1038/nrm2830 Protein folding (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111115 Tue, 22 Dec 2009 16:22:21 +0100 3111115 http://www.medworm.com/index.php?rid=3111114&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FoKLB9Z1w3uc%2Fnrm2829 Nature Reviews Molecular Cell Biology 11, 1 (2010). doi:10.1038/nrm2829 The morphology of eukaryotic cells is regulated by a dynamic filamentous network of proteins in the cytoplasm known as the cytoskeleton, which acts as a scaffold to maintain cell structure. Numerous proteins are involved in the regulation of the cytoskeleton. On page 62, Bruce (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111114 Tue, 22 Dec 2009 16:22:21 +0100 3111114 http://www.medworm.com/index.php?rid=3111113&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FmzFntXP5tnc%2Fnrm2828 Nature Reviews Molecular Cell Biology 11, 4 (2010). doi:10.1038/nrm2828 Author: Katharine H. Wrighton Lagging strand polymerase synthesizes DNA faster than leading strand polymerase. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111113 Tue, 22 Dec 2009 16:22:21 +0100 3111113 http://www.medworm.com/index.php?rid=3111112&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F5umJirj_LSA%2Fnrm2827 Nature Reviews Molecular Cell Biology 11, 4 (2010). doi:10.1038/nrm2827 Author: Kim Baumann Cell sorting at tissue boundaries depends on actomyosin-based mechanical tension. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111112 Tue, 22 Dec 2009 16:22:21 +0100 3111112 http://www.medworm.com/index.php?rid=3111111&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fo0TVCgNghsw%2Fnrm2826 Nature Reviews Molecular Cell Biology 11, 2 (2010). doi:10.1038/nrm2826 Author: Kim Baumann ABA receptors function as PP2C inhibitors in an ABA-dependent manner. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111111 Tue, 22 Dec 2009 16:22:21 +0100 3111111 http://www.medworm.com/index.php?rid=3111110&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FmmTZahkiroA%2Fnrm2825 Nature Reviews Molecular Cell Biology 11, 3 (2010). doi:10.1038/nrm2825 Author: Peter Friedl Non-adhesive cell migration occurs in 3D tissues. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111110 Tue, 22 Dec 2009 16:22:21 +0100 3111110 http://www.medworm.com/index.php?rid=3111109&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FqXPH5Xf_t9s%2Fnrm2822 Authors: Laura R. Pearce, David Komander & Dario R. Alessi The AGC kinase subfamily of protein kinases contains 60 members, including PKA, PKG and PKC. The family comprises some intensely examined protein kinases (such as Akt, S6K, RSK, MSK, PDK1 and GRK) as well as many less well-studied enzymes (such as SGK, NDR, LATS, CRIK, (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111109 Tue, 22 Dec 2009 16:22:21 +0100 3111109 http://www.medworm.com/index.php?rid=3111108&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FOdpmBDdaHqk%2Fnrm2821 Authors: Harvey W. Smith & Chris J. Marshall Urokinase-type plasminogen activator receptor (uPAR) expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. uPAR regulates proteolysis by binding the extracellular protease urokinase-type plasminogen activator (uPA; also known as urokinase) and also activates many (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111108 Tue, 22 Dec 2009 16:22:21 +0100 3111108 http://www.medworm.com/index.php?rid=3111107&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Frp3wktXeQ50%2Fnrm2818 Authors: Seyun Kim & Pierre A. Coulombe The cytoskeleton is an intricate and dynamic fibrous network that has an essential role in the generation and regulation of cell architecture and cellular mechanical properties. The cytoskeleton also evolved as a scaffold that supports diverse biochemical pathways. Recent evidence favours the hypothesis that the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111107 Tue, 22 Dec 2009 16:22:21 +0100 3111107 http://www.medworm.com/index.php?rid=3111106&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FWK2VAIQbPsQ%2Fnrm2815 Authors: Brian E. Richardson & Ruth Lehmann The regulated migration of cells is essential for development and tissue homeostasis, and aberrant cell migration can lead to an impaired immune response and the progression of cancer. Primordial germ cells (PGCs), precursors to sperm and eggs, have to migrate across the embryo to reach (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111106 Tue, 22 Dec 2009 16:22:21 +0100 3111106 http://www.medworm.com/index.php?rid=3111103&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F_-WlPyEh4Ew%2Fnrm2824 Nature Reviews Molecular Cell Biology 11, 6 (2010). doi:10.1038/nrm2824 Author: Francesca Cesari Ubiquitin chains are built by sequential transfer of single molecules. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111103 Wed, 09 Dec 2009 00:00:00 +0100 3111103 http://www.medworm.com/index.php?rid=3111102&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F9Tn288lpbfw%2Fnrm2823 Nature Reviews Molecular Cell Biology 11, 3 (2010). doi:10.1038/nrm2823 Author: Debbie Walker Intermediate filament assembly is regulated by sumoylation of IFB-1A (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111102 Wed, 09 Dec 2009 00:00:00 +0100 3111102 http://www.medworm.com/index.php?rid=3111101&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FZtGiP59cxB8%2Fnrm2820 Authors: Joseph R. Casey, Sergio Grinstein & John Orlowski Protons dictate the charge and structure of macromolecules and are used as energy currency by eukaryotic cells. The unique function of individual organelles therefore depends on the establishment and stringent maintenance of a distinct pH. This, in turn, requires a means to sense the prevailing (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111101 Wed, 09 Dec 2009 00:00:00 +0100 3111101 http://www.medworm.com/index.php?rid=3111100&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FG1B7RExvGso%2Fnrm2816 Authors: Melissa A. Chesarone, Amy Grace DuPage & Bruce L. Goode Formins are highly conserved proteins that have essential roles in remodelling the actin and microtubule cytoskeletons to influence eukaryotic cell shape and behaviour. Recent work has identified numerous cellular factors that locally recruit, activate or inactivate formins to bridle and unleash their potent effects on (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111100 Wed, 09 Dec 2009 00:00:00 +0100 3111100 http://www.medworm.com/index.php?rid=3111105&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FUb2megxy2k4%2Fnrm2819 Nature Reviews Molecular Cell Biology 11, 6 (2010). doi:10.1038/nrm2819 Author: Rachel David WASH multiprotein complex has an integral role in endosomal sorting. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111105 Wed, 02 Dec 2009 00:00:00 +0100 3111105 http://www.medworm.com/index.php?rid=3111104&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FszVO7HeSfrI%2Fnrm2817 Nature Reviews Molecular Cell Biology 11, 5 (2010). doi:10.1038/nrm2817 Author: Meera Swami Both strands of the miRNA duplex are sorted into AGO and can silence mRNA. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3111104 Wed, 02 Dec 2009 00:00:00 +0100 3111104 http://www.medworm.com/index.php?rid=3018860&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FFDT7dJrqEBw%2Fnrm2814 Nature Reviews Molecular Cell Biology 10, 811 (2009). doi:10.1038/nrm2814 This year p53 celebrates 30 years of research. We mark this occasion with a Poster highlighting some of the key discoveries that have led to our current understanding of p53 as a tumour suppressor that regulates many important biological activities, and is itself regulated by (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018860 Mon, 23 Nov 2009 16:24:09 +0100 3018860 http://www.medworm.com/index.php?rid=3018859&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FnezwMHI_m-I%2Fnrm2813 Nature Reviews Molecular Cell Biology 10, 816 (2009). doi:10.1038/nrm2813 On the DNA–RNA pivotThe RNA-induced silencing complex (RISC) mediates RNA cleavage by forming a complex with DNA and nascent RNA. The catalytic residues for RNA cleavage lie in the PIWI domain of the RISC component Argonaute (Ago). Now, Wang et al. define the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018859 Mon, 23 Nov 2009 16:24:09 +0100 3018859 http://www.medworm.com/index.php?rid=3018858&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FsN_A6tmyeHE%2Fnrm2812 Nature Reviews Molecular Cell Biology 10, 817 (2009). doi:10.1038/nrm2812 Reprogramming (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018858 Mon, 23 Nov 2009 16:24:09 +0100 3018858 http://www.medworm.com/index.php?rid=3018857&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FXDWZC-7mQvg%2Fnrm2811 Nature Reviews Molecular Cell Biology 10, 812 (2009). doi:10.1038/nrm2811 Author: Francesca Cesari Primary cilia are present on most eukaryotic cells, where they function as sensory organelles to relay information from the external environment into the cell. Cilia are assembled by means of intraflagellar transport (IFT) — a process carried out by multimeric IFT particles and molecular motors. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018857 Mon, 23 Nov 2009 16:24:09 +0100 3018857 http://www.medworm.com/index.php?rid=3018856&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FOSPw5KjYqqg%2Fnrm2810 Nature Reviews Molecular Cell Biology 10, 814 (2009). doi:10.1038/nrm2810 Author: Kim Baumann Sister chromatid cohesion ensures proper chromosome segregation and is mediated by the cohesin complex forming a ring around sister chromatids. How DNA replication forks go through cohesin-associated obstructions to achieve genome replication remains unclear. Prasad Jallepalli and colleagues now report that fork advancement depends on (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018856 Mon, 23 Nov 2009 16:24:09 +0100 3018856 http://www.medworm.com/index.php?rid=3018855&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FN0ZJOQV_YiI%2Fnrm2809 Nature Reviews Molecular Cell Biology 10, 814 (2009). doi:10.1038/nrm2809 Stem cells (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018855 Mon, 23 Nov 2009 16:24:09 +0100 3018855 http://www.medworm.com/index.php?rid=3018854&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F_PjXAtycV_0%2Fnrm2807 Authors: Nobutaka Hirokawa, Ryo Nitta & Yasushi Okada Most kinesins move processively along microtubules by using energy derived from ATP hydrolysis. Almost all of the intermediate structures of this ATPase reaction cycle have been solved for the monomeric kinesin 3 family motor KIF1A. Based on this structural information, we propose a common mechanism (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018854 Mon, 23 Nov 2009 16:24:09 +0100 3018854 http://www.medworm.com/index.php?rid=3018853&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FcCxA0Ij_QDg%2Fnrm2805 Authors: Philip A. Romero & Frances H. Arnold Directed evolution circumvents our profound ignorance of how a protein's sequence encodes its function by using iterative rounds of random mutation and artificial selection to discover new and useful proteins. Proteins can be tunedto adapt to new functions or environments by simple adaptive walks involving (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018853 Mon, 23 Nov 2009 16:24:09 +0100 3018853 http://www.medworm.com/index.php?rid=3018852&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FL4XQqcuFNII%2Fnrm2804 Authors: Julia R. Kardon & Ronald D. Vale Eukaryotic cells use cytoskeletal motor proteins to transport many different intracellular cargos. Numerous kinesins and myosins have evolved to cope with the various transport needs that have arisen during eukaryotic evolution. Surprisingly, a single cytoplasmic dynein (a minus end-directed microtubule motor) carries out similarly diverse (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018852 Mon, 23 Nov 2009 16:24:09 +0100 3018852 http://www.medworm.com/index.php?rid=3018851&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FEGJh-zpDxpI%2Fnrm2803 Authors: Stefanie L. Ritter & Randy A. Hall G protein-coupled receptors (GPCRs) mediate physiological responses to various ligands, such as hormones, neurotransmitters and sensory stimuli. The signalling and trafficking properties of GPCRs are often highly malleable depending on the cellular context. Such fine-tuning of GPCR function can be attributed in many cases to (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018851 Mon, 23 Nov 2009 16:24:09 +0100 3018851 http://www.medworm.com/index.php?rid=3018848&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FU_kSSLnBS0o%2Fnrm2799 Authors: Patrick T. Caswell, Suryakiran Vadrevu & Jim C. Norman Since it has become clear that adhesion receptors are trafficked through the endosomal pathway and that this can influence their function, much effort has been invested in obtaining detailed descriptions of the molecular machinery responsible for internalizing and recycling integrins. New findings indicate that integrin (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018848 Mon, 23 Nov 2009 16:24:09 +0100 3018848 http://www.medworm.com/index.php?rid=3018847&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FfV1bBsLgfRY%2Fnrm2797 Authors: Markus Affolter, Rolf Zeller & Emmanuel Caussinus Branched structures are evident at all levels of organization in living organisms. Many organs, such as the vascular system, lung, kidney and mammary gland, are heavily branched. In each of these cases, equally fascinating questions have been put forward, including those that address the cellular (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018847 Mon, 23 Nov 2009 16:24:09 +0100 3018847 http://www.medworm.com/index.php?rid=3018850&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FZWNGF_piXNQ%2Fnrm2808 Nature Reviews Molecular Cell Biology 10, 814 (2009). doi:10.1038/nrm2808 Author: Katharine H. Wrighton Fluorescence microscopy is limited by the fact that many light-absorbing chromophores do not emit a detectable level of fluorescence and are not easily tagged with fluorophores in a physiological context. Min and colleagues now show how non-fluorescent molecules can be imaged using a technique known (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018850 Wed, 11 Nov 2009 00:00:00 +0100 3018850 http://www.medworm.com/index.php?rid=3018849&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F5zisg5u0lPo%2Fnrm2806 Nature Reviews Molecular Cell Biology 10, 816 (2009). doi:10.1038/nrm2806 Author: Rachel David Mammalian circadian rhythms, which govern activities such as sleeping and eating, are regulated by a light-controlled master clock in the brain. Mammals also have clocks in their peripheral organs, which are regulated by nutrient availability through an unknown molecular mechanism. Now, Lamia et al. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018849 Wed, 11 Nov 2009 00:00:00 +0100 3018849 http://www.medworm.com/index.php?rid=3018846&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FrheOEftR0t0%2Fnrm2802 Nature Reviews Molecular Cell Biology 10, 815 (2009). doi:10.1038/nrm2802 Author: Kim Baumann On pathogen infection, plants initiate a rapid cell death programme — known as hypersensitive cell death — at the site of infection to prevent pathogens from spreading to healthy tissues. How cell death is executed and whether plants share cell death mechanisms with animals remains (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018846 Wed, 04 Nov 2009 00:00:00 +0100 3018846 http://www.medworm.com/index.php?rid=3018845&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FzP-RHF10C1A%2Fnrm2801 Nature Reviews Molecular Cell Biology 10, 813 (2009). doi:10.1038/nrm2801 Author: Emily J. Chenette The enzyme telomerase maintains chromosome integrity by synthesizing telomeres at chromosome ends. What prevents telomerase from adding telomeres to double-stranded DNA breaks (DSBs)? In Nature Cell Biology, Svetlana Makovets and Elizabeth Blackburn now report that DNA damage signalling induces phosphorylation of the telomerase inhibitor (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018845 Wed, 04 Nov 2009 00:00:00 +0100 3018845 http://www.medworm.com/index.php?rid=3018844&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FNBOtPusq1g4%2Fnrm2800 Nature Reviews Molecular Cell Biology 10, 813 (2009). doi:10.1038/nrm2800 Author: Mark Estelle For most of the past century, scientists interested in plant growth and development generally fell into two different camps. Those interested in growth worked on plant hormones such as the small indolic molecule auxin, which regulates plant cell division and expansion. Meanwhile, plant developmental biologists (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018844 Wed, 04 Nov 2009 00:00:00 +0100 3018844 http://www.medworm.com/index.php?rid=3018843&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fb6RCZpN8Zhk%2Fnrm2798 Nature Reviews Molecular Cell Biology 10, 816 (2009). doi:10.1038/nrm2798 Author: Iley Ozerlat Regulation of cell motility is important for the metastatic dissemination of tumour cells from their primary location to lymph or blood vessels. Transforming growth factor-β (TGFβ) signalling — which is mediated by Smad transcription factors — enhances cell motility and tumour progression. Erik Sahai and (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018843 Tue, 27 Oct 2009 00:00:00 +0100 3018843 http://www.medworm.com/index.php?rid=3018842&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F0kUS6yhFzA0%2Fnrm2796 Nature Reviews Molecular Cell Biology 10, 884 (2009). doi:10.1038/nrm2796 Author: Giulio Superti-Furga An explosion of scientific and technological advances has broadened the field of biomedicine. Traditional boundaries between the public and private research sectors are now blurred by multidisciplinary projects and the necessity for new and more efficient models of the translational process. This allows the adventurous (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=3018842 Tue, 27 Oct 2009 00:00:00 +0100 3018842 http://www.medworm.com/index.php?rid=2920056&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FrRd-Nhjmvz0%2Fnrm2789 Nature Reviews Molecular Cell Biology 10, 735 (2009). doi:10.1038/nrm2789 Author: Anne-Claude Gingras Whereas some important discoveries shine sudden and unexpected light on a research area, other seminal advances result from the contributions of several groups, and the realization of their impact comes years after the initial breakthrough. The discovery of the mRNA cap offers one example of (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920056 Fri, 23 Oct 2009 15:44:30 +0100 2920056 http://www.medworm.com/index.php?rid=2920055&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FDbGxvFj5gy0%2Fnrm2795 Nature Reviews Molecular Cell Biology 10, 733 (2009). doi:10.1038/nrm2795 The past month was particularly exciting for molecular and cell biologists. First, Elizabeth H. Blackburn, Carol W. Greider and Jack W. Szostak were awarded the Nobel Prize in Physiology or Medicine for the discovery of “how chromosomes are protected by telomeres and the enzyme telomerase”. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920055 Fri, 23 Oct 2009 15:44:30 +0100 2920055 http://www.medworm.com/index.php?rid=2920054&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F0C-S6asyVLE%2Fnrm2794 Nature Reviews Molecular Cell Biology 10, 738 (2009). doi:10.1038/nrm2794 Author: Kim Baumann Induced pluripotent stem (iPS) cells — somatic and adult stem cells that are reprogrammed to a pluripotent state by the transient expression of various transcription factors — offer great promise for future regenerative therapies. Two studies, published in Cell Stem Cell, now report the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920054 Fri, 23 Oct 2009 15:44:30 +0100 2920054 http://www.medworm.com/index.php?rid=2920053&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FC6n9zb52WaI%2Fnrm2793 Nature Reviews Molecular Cell Biology 10, 737 (2009). doi:10.1038/nrm2793 Transcription (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920053 Fri, 23 Oct 2009 15:44:30 +0100 2920053 http://www.medworm.com/index.php?rid=2920052&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FU0j9ytqrUhs%2Fnrm2792 Nature Reviews Molecular Cell Biology 10, 734 (2009). doi:10.1038/nrm2792 Author: Katharine H. Wrighton Mature microRNAs (miRNAs) result from the cleavage of precursor miRNAs by the miRNA-generating complex, which in humans consists of Dicer and the HIV TAR RNA-binding protein (TRBP). Some mature miRNAs promote cell growth, whereas others suppress it. Qinghua Liu and colleagues now show that the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920052 Fri, 23 Oct 2009 15:44:30 +0100 2920052 http://www.medworm.com/index.php?rid=2920051&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FugZ-8-Imv3o%2Fnrm2787 Evolution of biomolecular networks — lessons from metabolic and protein interactions Nature Reviews Molecular Cell Biology 10, 791 (2009). doi:10.1038/nrm2787 Authors: Takuji Yamada & Peer Bork Despite only becoming popular at the beginning of this decade, biomolecular networks are now frameworks that facilitate many discoveries in molecular biology. The nodes of these networks are usually proteins (specifically enzymes in metabolic networks), whereas the links (or edges) are their interactions with other (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920051 Fri, 23 Oct 2009 15:44:30 +0100 2920051 http://www.medworm.com/index.php?rid=2920050&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FmmNoVfz_gWc%2Fnrm2786 Authors: Miguel Vicente-Manzanares, Xuefei Ma, Robert S. Adelstein & Alan Rick Horwitz Non-muscle myosin II (NM II) is an actin-binding protein that has actin cross-linking and contractile properties and is regulated by the phosphorylation of its light and heavy chains. The three mammalian NM II isoforms have both overlapping and unique properties. Owing to its position downstream (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920050 Fri, 23 Oct 2009 15:44:30 +0100 2920050 http://www.medworm.com/index.php?rid=2920049&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fqq1YZivT-2A%2Fnrm2784 Biased segregation of DNA and centrosomes — moving together or drifting apart? Nature Reviews Molecular Cell Biology 10, 804 (2009). doi:10.1038/nrm2784 Authors: Shahragim Tajbakhsh & Cayetano Gonzalez Old and newly synthesized centrosomes have different microtubule nucleating abilities and they contribute to cell polarity when they migrate to opposite poles during cell division. The asymmetric localization of epigenetic marks and kinetochore proteins could lead to the differential recognition of sister chromatids and the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920049 Fri, 23 Oct 2009 15:44:30 +0100 2920049 http://www.medworm.com/index.php?rid=2920048&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F1tFHXQhMn7E%2Fnrm2782 Authors: Kristen J. Verhey & Jennetta W. Hammond Kinesins are a family of molecular motors that use the energy of ATP hydrolysis to move along the surface of, or destabilize, microtubule filaments. Much progress has been made in understanding the mechanics and functions of the kinesin motors that play important parts in cell (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920048 Fri, 23 Oct 2009 15:44:30 +0100 2920048 http://www.medworm.com/index.php?rid=2920047&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FgbiXFr3MhFs%2Fnrm2780 Authors: Yihong Ye & Michael Rape The modification of proteins with ubiquitin chains can change their localization, activity and/or stability. Although ubiquitylation requires the concerted action of ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s), it is the E2s that have recently emerged as key mediators of chain assembly. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920047 Fri, 23 Oct 2009 15:44:30 +0100 2920047 http://www.medworm.com/index.php?rid=2920046&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FlXDJQDCSXkE%2Fnrm2791 Nature Reviews Molecular Cell Biology 10, 738 (2009). doi:10.1038/nrm2791 Author: Mary Muers The list of biological processes that are controlled by chromatin structure or small RNAs has expanded rapidly in recent years, and a few examples are emerging in which these two modes of regulation are connected. Research presented in three companion papers now links an RNA (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920046 Tue, 13 Oct 2009 23:00:00 +0100 2920046 http://www.medworm.com/index.php?rid=2920045&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F9whYG2KTYa0%2Fnrm2790 Nature Reviews Molecular Cell Biology 10, 735 (2009). doi:10.1038/nrm2790 Author: Francesca Cesari Autophagy-related protein 5 (ATG5) and ATG7 are thought to be essential for mammalian autophagy (also known as macroautophagy) — the lysosomal breakdown of organelles, proteins and other components of the cytoplasm to sustain metabolism during starvation and metabolic stress. Now, a study in Nature (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920045 Tue, 13 Oct 2009 23:00:00 +0100 2920045 http://www.medworm.com/index.php?rid=2920044&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F6J0oAYjgY-M%2Fnrm2788 Nature Reviews Molecular Cell Biology 10, 739 (2009). doi:10.1038/nrm2788 Author: Katharine H. Wrighton In the mitochondrial apoptosis pathway, cellular stress induces mitochondrial outer membrane permeabilization (MOMP). This results in the release of proteins from the mitochondrial intermembrane space that activate caspase cysteine proteases. So-called initiator caspases cleave and activate downstream caspases, which subsequently cleave other cellular substrates to (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920044 Tue, 13 Oct 2009 23:00:00 +0100 2920044 http://www.medworm.com/index.php?rid=2920043&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F_jrzULUt4V0%2Fnrm2785 Nature Reviews Molecular Cell Biology 10, 736 (2009). doi:10.1038/nrm2785 Author: Kim Baumann This year's Albert Lasker Basic Medical Research Award goes to John Gurdon and Shinya Yamanaka for their discoveries on nuclear reprogramming. This process instructs fully differentiated adult cells to revert to early embryonic stem (ES) cells, which, when transplanted into an egg, can restart (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920043 Wed, 07 Oct 2009 23:00:00 +0100 2920043 http://www.medworm.com/index.php?rid=2920042&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F4IWeD4tuORs%2Fnrm2783 Nature Reviews Molecular Cell Biology 10, 736 (2009). doi:10.1038/nrm2783 Author: Kim Baumann Janus kinase 2 (JAK2) is a non-receptor tyrosine kinase known to initiate cytoplasmic signalling cascades that regulate various processes, including cell cycle progression, apoptosis, mitotic recombination, genetic instability and heterochromatin modifications. In Nature, Tony Kouzarides and colleagues now report an unprecedented role for JAK2 (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920042 Wed, 07 Oct 2009 23:00:00 +0100 2920042 http://www.medworm.com/index.php?rid=2920041&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fl0AbJ-jHQYY%2Fnrm2781 Nature Reviews Molecular Cell Biology 10, 736 (2009). doi:10.1038/nrm2781 Author: Rachel David MicroRNAs (miRNAs) function in post-transcriptional gene silencing by directly inhibiting mRNA translation or by inducing mRNA deadenylation, which promotes mRNA decay. Fabian et al., in a paper published in Molecular Cell, provide new insights into the mechanism by which miRNAs promote mRNA deadenylation (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920041 Wed, 30 Sep 2009 23:00:00 +0100 2920041 http://www.medworm.com/index.php?rid=2828036&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F_T8-YL_x50o%2Fnrm2779 Nature Reviews Molecular Cell Biology 10, 656 (2009). doi:10.1038/nrm2779 Cell death (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828036 Thu, 24 Sep 2009 18:13:27 +0100 2828036 http://www.medworm.com/index.php?rid=2828035&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FYFti5CLclAs%2Fnrm2778 Nature Reviews Molecular Cell Biology 10, 657 (2009). doi:10.1038/nrm2778 Author: Rachel David Four rhesus macaques have been created in a laboratory at the Oregon National Primate Research Center, USA, using a technique that could prevent the genetic transmission of diseases carried in mitochondrial DNA (mtDNA), as reported in Nature. By taking the nuclear DNA from one (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828035 Thu, 24 Sep 2009 18:13:27 +0100 2828035 http://www.medworm.com/index.php?rid=2828034&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FOiYYkKPrU_c%2Fnrm2776 Nature Reviews Molecular Cell Biology 10, 652 (2009). doi:10.1038/nrm2776 Author: Katharine H. Wrighton The biogenesis of mature microRNAs (miRNAs) involves the cleavage of primary miRNAs by Drosha and the cleavage of the resulting precursor (pre)-miRNAs by Dicer. Previous work from Narry Kim's laboratory has shown that the pluripotency factor LIN28 can induce the terminal uridylation of pre-let-7 miRNA (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828034 Thu, 24 Sep 2009 18:13:27 +0100 2828034 http://www.medworm.com/index.php?rid=2828033&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Flx2dS4r5BvI%2Fnrm2775 Nature Reviews Molecular Cell Biology 10, 651 (2009). doi:10.1038/nrm2775 Eukaryotic cells use motor proteins that move along cytoskeletal polymers to transport various intracellular cargos, including membranous organelles, protein complexes and mRNAs. Transport along microtubule filaments is mediated by kinesins and dyneins, whereas transport along actin filaments is mediated by myosins. Molecular motors convert the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828033 Thu, 24 Sep 2009 18:13:27 +0100 2828033 http://www.medworm.com/index.php?rid=2828032&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Flvif1QdVJHY%2Fnrm2774 Authors: Nobutaka Hirokawa, Yasuko Noda, Yosuke Tanaka & Shinsuke Niwa Intracellular transport is fundamental for cellular function, survival and morphogenesis. Kinesin superfamily proteins (also known as KIFs) are important molecular motors that directionally transport various cargos, including membranous organelles, protein complexes and mRNAs. The mechanisms by which different kinesins recognize and bind to specific cargos, (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828032 Thu, 24 Sep 2009 18:13:27 +0100 2828032 http://www.medworm.com/index.php?rid=2828031&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FpM33SGKIPrM%2Fnrm2767 Ubiquitin-binding domains — from structures to functions Nature Reviews Molecular Cell Biology 10, 659 (2009). doi:10.1038/nrm2767 Authors: Ivan Dikic, Soichi Wakatsuki & Kylie J. Walters Ubiquitin-binding domains (UBDs) are modular elements that bind non-covalently to the protein modifier ubiquitin. Recent atomic-level resolution structures of ubiquitin–UBD complexes have revealed some of the mechanisms that underlie the versatile functions of ubiquitin in vivo. The preferences of UBDs for ubiquitin chains of (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828031 Thu, 24 Sep 2009 18:13:27 +0100 2828031 http://www.medworm.com/index.php?rid=2920040&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FRauYDEYTR9I%2Fnrm2777 Authors: Mo Chen & James L. Manley Alternative splicing of mRNA precursors provides an important means of genetic control and is a crucial step in the expression of most genes. Alternative splicing markedly affects human development, and its misregulation underlies many human diseases. Although the mechanisms of alternative splicing have been studied (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2920040 Tue, 22 Sep 2009 23:00:00 +0100 2920040 http://www.medworm.com/index.php?rid=2819910&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FLLOP8cO01i0%2Fnrm2751 Nature Reviews Molecular Cell Biology 10, 583 (2009). doi:10.1038/nrm2751 Author: Linton M. Traub Clathrin-mediated endocytosis oversees the constitutive packaging of selected membrane cargoes into transport vesicles that fuse with early endosomes. The process is responsive to activation of signalling receptors and ion channels, promptly clearing post-translationally tagged forms of cargo off the plasma membrane. To accommodate the diverse (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819910 Tue, 22 Sep 2009 18:18:27 +0100 2819910 http://www.medworm.com/index.php?rid=2819909&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FFDiGs761aO0%2Fnrm2760 Nature Reviews Molecular Cell Biology 10, 580 (2009). doi:10.1038/nrm2760 RNA decay (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819909 Tue, 22 Sep 2009 18:18:27 +0100 2819909 http://www.medworm.com/index.php?rid=2819908&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FdY21iXejA9g%2Fnrm2759 Nature Reviews Molecular Cell Biology 10, 577 (2009). doi:10.1038/nrm2759 Author: Francesca Cesari One of the main challenges in mass spectrometry (MS)-based methods is to achieve fast and precise quantitative analysis of any protein (or set of proteins) of interest in a proteome. According to two new studies by Ruedi Aebersold and colleagues this is now possible.Malmström (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819908 Tue, 22 Sep 2009 18:18:27 +0100 2819908 http://www.medworm.com/index.php?rid=2819907&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FGRuZasF9v4s%2Fnrm2758 Nature Reviews Molecular Cell Biology 10, 575 (2009). doi:10.1038/nrm2758 Endocytic membrane trafficking involves the cellular internalization and sorting of extracellular molecules, plasma membrane proteins and lipids. It is well established that endocytosis regulates receptor-mediated signalling, as Alexander Sorkin and Mark von Zastrow discuss on page 609. Conversely, signalling events can regulate the endocytic (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819907 Tue, 22 Sep 2009 18:18:27 +0100 2819907 http://www.medworm.com/index.php?rid=2819906&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FGnToDt4KwbY%2Fnrm2757 Nature Reviews Molecular Cell Biology 10, 581 (2009). doi:10.1038/nrm2757 Author: Arianne Heinrichs Sorting of ubiquitylated cargo proteins, such as transmembrane receptors, into multivesicular bodies (endosomes filled with intraluminal vesicles (ILVs)) is catalysed by the ESCRT (endosomal sorting complex required for transport) machinery. ESCRT-0, ESCRT-I and ESCRT-II bind cargo proteins, ESCRT-III remodels the membrane, and the Vps4–Vta1 complex (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819906 Tue, 22 Sep 2009 18:18:27 +0100 2819906 http://www.medworm.com/index.php?rid=2819905&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fzk0sgTj7qkw%2Fnrm2756 Nature Reviews Molecular Cell Biology 10, 579 (2009). doi:10.1038/nrm2756 Endocytosis (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819905 Tue, 22 Sep 2009 18:18:27 +0100 2819905 http://www.medworm.com/index.php?rid=2819904&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FNGzNS9OyJ6Q%2Fnrm2755 Authors: Barth D. Grant & Julie G. Donaldson Endocytic recycling is coordinated with endocytic uptake to control the composition of the plasma membrane. Although much of our understanding of endocytic recycling has come from studies on the transferrin receptor, a protein internalized through clathrin-dependent endocytosis, increased interest in clathrin-independent endocytosis has led to (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819904 Tue, 22 Sep 2009 18:18:27 +0100 2819904 http://www.medworm.com/index.php?rid=2819903&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FgcqRbyHiC3Y%2Fnrm2748 Authors: Alexander Sorkin & Mark von Zastrow Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct processes. Although our present understanding is incomplete and there are still great controversies, it is now recognized that these processes are intimately and bidirectionally linked in animal cells. Indeed, many recent examples illustrate (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819903 Tue, 22 Sep 2009 18:18:27 +0100 2819903 http://www.medworm.com/index.php?rid=2828029&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FQN1rwJNv0AY%2Fnrm2762 Authors: Catherine L. Worth, Sungsam Gong & Tom L. Blundell High-throughput genomic sequencing has focused attention on understanding differences between species and between individuals. When this genetic variation affects protein sequences, the rate of amino acid substitution reflects both Darwinian selection for functionally advantageous mutations and selectively neutral evolution operating within the constraints of structure (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828029 Tue, 15 Sep 2009 23:00:00 +0100 2828029 http://www.medworm.com/index.php?rid=2828030&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FwywBeCW1ZqA%2Fnrm2769 Nature Reviews Molecular Cell Biology 10, 653 (2009). doi:10.1038/nrm2769 Author: Alan Rick Horwitz The extracellular matrix (ECM), the complexity of which once rendered it an ugly stepchild of cell biology, is undergoing another renaissance. Originally recognized as the glue that holds tissues together, it became apparent in the 1960s that the ECM also dictates cellular behaviour; for example, (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828030 Tue, 08 Sep 2009 23:00:00 +0100 2828030 http://www.medworm.com/index.php?rid=2828028&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FsQ2pWrZFxwI%2Fnrm2764 Authors: Moran Benhar, Michael T. Forrester & Jonathan S. Stamler S-Nitrosylation, the redox-based modification of Cys thiol side chains by nitric oxide, is a common mechanism in signal transduction. Dysregulated S-nitrosylation contributes to a range of human pathologies. New roles for protein denitrosylation in regulating S-nitrosylation are being revealed. Recently, several denitrosylases (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828028 Tue, 08 Sep 2009 23:00:00 +0100 2828028 http://www.medworm.com/index.php?rid=2828027&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FqkpT624ho54%2Fnrm2773 Nature Reviews Molecular Cell Biology 10, 655 (2009). doi:10.1038/nrm2773 Author: Arianne Heinrichs The underlying causes of cell-to-cell variation in cell populations are poorly understood. Using systems biology approaches, Lucas Pelkmans and colleagues demonstrate that the characteristics of a cell population partly determine the attributes of individual cells, including their susceptibility to viral infection, endocytic features and membrane (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828027 Tue, 08 Sep 2009 23:00:00 +0100 2828027 http://www.medworm.com/index.php?rid=2828026&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FwJnz8EO8zqk%2Fnrm2772 Nature Reviews Molecular Cell Biology 10, 654 (2009). doi:10.1038/nrm2772 Author: Rachel David How the replication of mitochondrial DNA (mtDNA) is synchronized with nuclear DNA replication and how the copy number is maintained are largely unclear. However, a new study of trypanosome kinetoplast DNA (kDNA) — mtDNA that consists of minicircles and maxicircles — reveals how maxicircle replication (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828026 Tue, 08 Sep 2009 23:00:00 +0100 2828026 http://www.medworm.com/index.php?rid=2828025&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FMJD5cmci3zs%2Fnrm2766 Authors: Ben D. MacArthur, Avi Ma'ayan & Ihor R. Lemischka Stem cell differentiation and the maintenance of self-renewal are intrinsically complex processes requiring the coordinated dynamic expression of hundreds of genes and proteins in precise response to external signalling cues. Numerous recent reports have used both experimental and computational techniques to dissect this complexity. These (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828025 Tue, 08 Sep 2009 23:00:00 +0100 2828025 http://www.medworm.com/index.php?rid=2828024&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FGpBaYJVPJg0%2Fnrm2763 Authors: Jeffrey A. Simon & Robert E. Kingston Polycomb proteins form chromatin-modifying complexes that implement transcriptional silencing in higher eukaryotes. Hundreds of genes are silenced by Polycomb proteins, including dozens of genes that encode crucial developmental regulators in organisms ranging from plants to humans. Two main families of complexes, called Polycomb repressive complex (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828024 Tue, 08 Sep 2009 23:00:00 +0100 2828024 http://www.medworm.com/index.php?rid=2828023&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FgbVBzHNb-Pw%2Fnrm2771 Nature Reviews Molecular Cell Biology 10, 656 (2009). doi:10.1038/nrm2771 Author: Arianne Heinrichs Components of microRNA (miRNA)-mediated post-transcriptional silencing are known to congregate in cytoplasmic foci. New research published in Nature Cell Biology suggests that P bodies and GW bodies, cytoplasmic foci that were previously thought to be identical, can be differentiated by the fact that components (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828023 Wed, 02 Sep 2009 23:00:00 +0100 2828023 http://www.medworm.com/index.php?rid=2828022&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F1CsznTYx4_Y%2Fnrm2770 Nature Reviews Molecular Cell Biology 10, 656 (2009). doi:10.1038/nrm2770 Author: Francesca Cesari Eukaryotic genomes encode numerous antisense transcripts that are involved in different aspects of gene regulation, but their accumulation can be deleterious and is therefore suppressed by exosome-mediated mRNA degradation. Now, a study published in Nature suggests that the histone variant H2AZ cooperates with heterochromatin (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828022 Wed, 02 Sep 2009 23:00:00 +0100 2828022 http://www.medworm.com/index.php?rid=2828021&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FtBRmi3aily4%2Fnrm2768 Nature Reviews Molecular Cell Biology 10, 654 (2009). doi:10.1038/nrm2768 Author: Kim Baumann The GTPases RHOA, RAC1 and CDC42 control the actin cytoskeleton dynamics that provide the force for cell motility. All three GTPases are activated at the cell front and regulate each other; however, their fine spatiotemporal coordination and mutual regulation are not well characterized. Two studies (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828021 Wed, 02 Sep 2009 23:00:00 +0100 2828021 http://www.medworm.com/index.php?rid=2828020&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FWLheg74AQOY%2Fnrm2765 Nature Reviews Molecular Cell Biology 10, 653 (2009). doi:10.1038/nrm2765 Author: Emily J. Chenette The E3 ubiquitin ligase TNF receptor-associated factor 6 (TRAF6) is known to activate nuclear factor-κB (NF-κB) downstream of the interleukin-1 and Toll-like receptors. Together with the ubiquitin-conjugating E2-type enzymes UBC13 and UEV1A (also known as UBE2V1), TRAF6 catalyses Lys63-linked ubiquitylation, which stimulates (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2828020 Wed, 02 Sep 2009 23:00:00 +0100 2828020 http://www.medworm.com/index.php?rid=2719589&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2751 Nature Reviews Molecular Cell Biology 10, 583 (2009). doi:10.1038/nrm2751 Author: Linton M. Traub Clathrin-mediated endocytosis oversees the constitutive packaging of selected membrane cargoes into transport vesicles that fuse with early endosomes. The process is responsive to activation of signalling receptors and ion channels, promptly clearing post-translationally tagged forms of cargo off the plasma membrane. To accommodate the diverse (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719589 Fri, 21 Aug 2009 11:53:15 +0100 2719589 http://www.medworm.com/index.php?rid=2719588&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2760 Nature Reviews Molecular Cell Biology 10, 580 (2009). doi:10.1038/nrm2760 RNA decay (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719588 Fri, 21 Aug 2009 11:53:15 +0100 2719588 http://www.medworm.com/index.php?rid=2719587&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2759 Nature Reviews Molecular Cell Biology 10, 577 (2009). doi:10.1038/nrm2759 Author: Francesca Cesari One of the main challenges in mass spectrometry (MS)-based methods is to achieve fast and precise quantitative analysis of any protein (or set of proteins) of interest in a proteome. According to two new studies by Ruedi Aebersold and colleagues this is now possible.Malmström (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719587 Fri, 21 Aug 2009 11:53:15 +0100 2719587 http://www.medworm.com/index.php?rid=2719586&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2758 Nature Reviews Molecular Cell Biology 10, 575 (2009). doi:10.1038/nrm2758 Endocytic membrane trafficking involves the cellular internalization and sorting of extracellular molecules, plasma membrane proteins and lipids. It is well established that endocytosis regulates receptor-mediated signalling, as Alexander Sorkin and Mark von Zastrow discuss on page 609. Conversely, signalling events can regulate the endocytic (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719586 Fri, 21 Aug 2009 11:53:15 +0100 2719586 http://www.medworm.com/index.php?rid=2719585&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2757 Nature Reviews Molecular Cell Biology 10, 581 (2009). doi:10.1038/nrm2757 Author: Arianne Heinrichs Sorting of ubiquitylated cargo proteins, such as transmembrane receptors, into multivesicular bodies (endosomes filled with intraluminal vesicles (ILVs)) is catalysed by the ESCRT (endosomal sorting complex required for transport) machinery. ESCRT-0, ESCRT-I and ESCRT-II bind cargo proteins, ESCRT-III remodels the membrane, and the Vps4–Vta1 complex (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719585 Fri, 21 Aug 2009 11:53:15 +0100 2719585 http://www.medworm.com/index.php?rid=2719584&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2756 Nature Reviews Molecular Cell Biology 10, 579 (2009). doi:10.1038/nrm2756 Endocytosis (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719584 Fri, 21 Aug 2009 11:53:15 +0100 2719584 http://www.medworm.com/index.php?rid=2719583&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2755 Authors: Barth D. Grant & Julie G. Donaldson Endocytic recycling is coordinated with endocytic uptake to control the composition of the plasma membrane. Although much of our understanding of endocytic recycling has come from studies on the transferrin receptor, a protein internalized through clathrin-dependent endocytosis, increased interest in clathrin-independent endocytosis has led to (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719583 Fri, 21 Aug 2009 11:53:15 +0100 2719583 http://www.medworm.com/index.php?rid=2719582&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2748 Authors: Alexander Sorkin & Mark von Zastrow Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct processes. Although our present understanding is incomplete and there are still great controversies, it is now recognized that these processes are intimately and bidirectionally linked in animal cells. Indeed, many recent examples illustrate (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719582 Fri, 21 Aug 2009 11:53:15 +0100 2719582 http://www.medworm.com/index.php?rid=2819902&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F9d_sslamskE%2Fnrm2754 Nature Reviews Molecular Cell Biology 10, 578 (2009). doi:10.1038/nrm2754 Author: Francesca Cesari Precise control of small RNA levels is crucial to maintain normal cellular function. Two studies in Cell now identify arsenate resistance protein 2 (ARS2) as a new component of the nuclear RNA cap-binding complex (CBC) that stimulates microRNA (miRNA) processing and is crucial for (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819902 Tue, 11 Aug 2009 23:00:00 +0100 2819902 http://www.medworm.com/index.php?rid=2819901&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FKAhCvKTnjn4%2Fnrm2753 Nature Reviews Molecular Cell Biology 10, 578 (2009). doi:10.1038/nrm2753 Author: Katharine H. Wrighton Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by the expression of defined transcription factors. However, although iPS cells share many of the features of embryonic stem cells and can be differentiated into multiple cell types, the low efficiency of iPS cell (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819901 Tue, 11 Aug 2009 23:00:00 +0100 2819901 http://www.medworm.com/index.php?rid=2819900&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fx6UMtD4d7G4%2Fnrm2752 Nature Reviews Molecular Cell Biology 10, 580 (2009). doi:10.1038/nrm2752 Author: Rachel David Microtubule plus end-tracking proteins (+TIPs) are a diverse group of proteins involved in numerous cell activities, including the regulation of cell shape. Recently, it was discovered that end-binding protein 1 (EB1; also known as MAPRE1) regulates the interaction of +TIPs with microtubule ends, but the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819900 Tue, 11 Aug 2009 23:00:00 +0100 2819900 http://www.medworm.com/index.php?rid=2819899&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FAnICRuYf8B4%2Fnrm2746 Authors: Allen P. Liu & Daniel A. Fletcher We are much better at taking cells apart than putting them together. Reconstitution of biological processes from component molecules has been a powerful but difficult approach to studying functional organization in biology. Recently, the convergence of biochemical and cell biological advances with new experimental and (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819899 Tue, 11 Aug 2009 23:00:00 +0100 2819899 http://www.medworm.com/index.php?rid=2819898&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F3wID7Mt4_7U%2Fnrm2745 Authors: Paul Saftig & Judith Klumperman Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade extracellular material that has been internalized by endocytosis and intracellular components that have been sequestered by autophagy. In addition, specialized cells contain lysosome-related organelles that store and secrete proteins for cell-type-specific functions. The functioning (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819898 Tue, 11 Aug 2009 23:00:00 +0100 2819898 http://www.medworm.com/index.php?rid=2719581&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2754 Nature Reviews Molecular Cell Biology 10, 578 (2009). doi:10.1038/nrm2754 Author: Francesca Cesari Precise control of small RNA levels is crucial to maintain normal cellular function. Two studies in Cell now identify arsenate resistance protein 2 (ARS2) as a new component of the nuclear RNA cap-binding complex (CBC) that stimulates microRNA (miRNA) processing and is crucial for (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719581 Tue, 11 Aug 2009 23:00:00 +0100 2719581 http://www.medworm.com/index.php?rid=2719580&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2753 Nature Reviews Molecular Cell Biology 10, 578 (2009). doi:10.1038/nrm2753 Author: Katharine H. Wrighton Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by the expression of defined transcription factors. However, although iPS cells share many of the features of embryonic stem cells and can be differentiated into multiple cell types, the low efficiency of iPS cell (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719580 Tue, 11 Aug 2009 23:00:00 +0100 2719580 http://www.medworm.com/index.php?rid=2719579&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2752 Nature Reviews Molecular Cell Biology 10, 580 (2009). doi:10.1038/nrm2752 Author: Rachel David Microtubule plus end-tracking proteins (+TIPs) are a diverse group of proteins involved in numerous cell activities, including the regulation of cell shape. Recently, it was discovered that end-binding protein 1 (EB1; also known as MAPRE1) regulates the interaction of +TIPs with microtubule ends, but the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719579 Tue, 11 Aug 2009 23:00:00 +0100 2719579 http://www.medworm.com/index.php?rid=2719578&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2746 Authors: Allen P. Liu & Daniel A. Fletcher We are much better at taking cells apart than putting them together. Reconstitution of biological processes from component molecules has been a powerful but difficult approach to studying functional organization in biology. Recently, the convergence of biochemical and cell biological advances with new experimental and (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719578 Tue, 11 Aug 2009 23:00:00 +0100 2719578 http://www.medworm.com/index.php?rid=2719577&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2745 Authors: Paul Saftig & Judith Klumperman Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade extracellular material that has been internalized by endocytosis and intracellular components that have been sequestered by autophagy. In addition, specialized cells contain lysosome-related organelles that store and secrete proteins for cell-type-specific functions. The functioning (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719577 Tue, 11 Aug 2009 23:00:00 +0100 2719577 http://www.medworm.com/index.php?rid=2819897&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FUNm19L_HDTU%2Fnrm2750 Nature Reviews Molecular Cell Biology 10, 582 (2009). doi:10.1038/nrm2750 Author: Arianne Heinrichs Centromeric nucleosomes are characterized by the presence of one or more centromeric histone H3 (CenH3; known as CID in Drosophila melanogaster and Cse4 in Saccharomyces cerevisiae) variants that replace canonical histone H3. However, little is known about the structural features of centromeres that (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819897 Tue, 04 Aug 2009 23:00:00 +0100 2819897 http://www.medworm.com/index.php?rid=2819896&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fyf7BvgjMbOo%2Fnrm2749 Nature Reviews Molecular Cell Biology 10, 580 (2009). doi:10.1038/nrm2749 Author: Katharine H. Wrighton The downregulation of certain microRNAs (miRNAs) in cancer can promote tumorigenesis. Miyazono and colleagues now firmly link miRNAs to the tumour suppressor network by showing that the tumour suppressor protein p53 is an important regulator of miRNA processing.The processing of primary (pri)-miRNA transcripts into (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819896 Tue, 04 Aug 2009 23:00:00 +0100 2819896 http://www.medworm.com/index.php?rid=2819895&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fa665sdPqN0Q%2Fnrm2747 Nature Reviews Molecular Cell Biology 10, 582 (2009). doi:10.1038/nrm2747 Author: Harald Stenmark Developments in light microscopy, in particular in confocal fluorescence microscopy, have contributed tremendously to our understanding of intracellular membrane trafficking (notably endocytosis) during the past two decades. However, many key discoveries in cell biology would not have been possible without the ultra-high resolution of the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819895 Tue, 04 Aug 2009 23:00:00 +0100 2819895 http://www.medworm.com/index.php?rid=2719576&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2750 Nature Reviews Molecular Cell Biology 10, 582 (2009). doi:10.1038/nrm2750 Author: Arianne Heinrichs Centromeric nucleosomes are characterized by the presence of one or more centromeric histone H3 (CenH3; known as CID in Drosophila melanogaster and Cse4 in Saccharomyces cerevisiae) variants that replace canonical histone H3. However, little is known about the structural features of centromeres that (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719576 Tue, 04 Aug 2009 23:00:00 +0100 2719576 http://www.medworm.com/index.php?rid=2719575&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2749 Nature Reviews Molecular Cell Biology 10, 580 (2009). doi:10.1038/nrm2749 Author: Katharine H. Wrighton The downregulation of certain microRNAs (miRNAs) in cancer can promote tumorigenesis. Miyazono and colleagues now firmly link miRNAs to the tumour suppressor network by showing that the tumour suppressor protein p53 is an important regulator of miRNA processing.The processing of primary (pri)-miRNA transcripts into (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719575 Tue, 04 Aug 2009 23:00:00 +0100 2719575 http://www.medworm.com/index.php?rid=2719574&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2747 Nature Reviews Molecular Cell Biology 10, 582 (2009). doi:10.1038/nrm2747 Author: Harald Stenmark Developments in light microscopy, in particular in confocal fluorescence microscopy, have contributed tremendously to our understanding of intracellular membrane trafficking (notably endocytosis) during the past two decades. However, many key discoveries in cell biology would not have been possible without the ultra-high resolution of the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719574 Tue, 04 Aug 2009 23:00:00 +0100 2719574 http://www.medworm.com/index.php?rid=2819894&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FU98oY9SI5vE%2Fnrm2738 Authors: Mohammad Ali Faghihi & Claes Wahlestedt Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2819894 Tue, 28 Jul 2009 23:00:00 +0100 2819894 http://www.medworm.com/index.php?rid=2719573&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2738 Authors: Mohammad Ali Faghihi & Claes Wahlestedt Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2719573 Tue, 28 Jul 2009 23:00:00 +0100 2719573 http://www.medworm.com/index.php?rid=2629944&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2744 Nature Reviews Molecular Cell Biology 10, 507 (2009). doi:10.1038/nrm2744 Stem cellsA parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2629944 Thu, 23 Jul 2009 12:25:14 +0100 2629944 http://www.medworm.com/index.php?rid=2629943&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2743 Nature Reviews Molecular Cell Biology 10, 501 (2009). doi:10.1038/nrm2743 Mammals undergo phases of cellular reprogramming and differentiation during their development from zygote to adult. Underlying these changes are epigenetic and transcription mechanisms, as discussed in a Review by Myriam Hemberger, Wendy Dean and Wolf Reik (page 526; see the Article Series on Chromatin (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2629943 Thu, 23 Jul 2009 12:25:14 +0100 2629943 http://www.medworm.com/index.php?rid=2629942&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2742 Nature Reviews Molecular Cell Biology 10, 506 (2009). doi:10.1038/nrm2742 Author: Katharine H. Wrighton Gene expression atlas˙ http://www.ebi.ac.uk/gxaAs biologists we all face the same questions when choosing our experimental system. Are we using a representative cell line? Which cells and organs express our gene of interest? Does the expression level of our gene vary under different biological (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2629942 Thu, 23 Jul 2009 12:25:14 +0100 2629942 http://www.medworm.com/index.php?rid=2629941&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2741 Nature Reviews Molecular Cell Biology 10, 503 (2009). doi:10.1038/nrm2741 Author: Ineke Braakman Sometimes a discovery changes everything. Like the car changed the world. Like photography changed our collective memory. In a similar way, the discovery of the sulfhydryl oxidase Ero1 (endoplasmic oxidoreductin 1) by the laboratories of Chris Kaiser and Jonathan Weissman, through a yeast genetic screen (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2629941 Thu, 23 Jul 2009 12:25:14 +0100 2629941 http://www.medworm.com/index.php?rid=2629940&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2740 Nature Reviews Molecular Cell Biology 10, 505 (2009). doi:10.1038/nrm2740 Author: Francesca Cesari Whereas much progress has been made in understanding the function of the enzymes that conjugate ubiquitin to target proteins, little is known about those that remove this post-translational modification — the deubiquitylating enzymes (DUBs). Now, Wade Harper and colleagues report a global proteomic analysis that (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2629940 Thu, 23 Jul 2009 12:25:14 +0100 2629940 http://www.medworm.com/index.php?rid=2629939&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2731 Authors: David Komander, Michael J. Clague & Sylvie Urbé Ubiquitylation is a reversible protein modification that is implicated in many cellular functions. Recently, much progress has been made in the characterization of a superfamily of isopeptidases that remove ubiquitin: the deubiquitinases (DUBs; also known as deubiquitylating or deubiquitinating enzymes). Far from being uniform in (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2629939 Thu, 23 Jul 2009 12:25:14 +0100 2629939 http://www.medworm.com/index.php?rid=2629938&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2730 Nature Reviews Molecular Cell Biology 10, 509 (2009). doi:10.1038/nrm2730 Author: Howard D. Lipshitz Morphogens are molecules that specify cell fate in a concentration-dependent manner. A classic example is the Bicoid (BCD) protein, for which the prevailing model is that translation of bcd mRNA occurs from a point source at the anterior pole of the Drosophila melanogaster (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2629938 Thu, 23 Jul 2009 12:25:14 +0100 2629938 http://www.medworm.com/index.php?rid=2629937&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2729 Authors: Ryan J. Petrie, Andrew D. Doyle & Kenneth M. Yamada Directional migration is an important component of cell motility. Although the basic mechanisms of random cell movement are well characterized, no single model explains the complex regulation of directional migration. Multiple factors operate at each step of cell migration to stabilize lamellipodia and maintain directional (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2629937 Tue, 14 Jul 2009 23:00:00 +0100 2629937 http://www.medworm.com/index.php?rid=2629936&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2728 Nature Reviews Molecular Cell Biology 10, 513 (2009). doi:10.1038/nrm2728 Author: Harald Stenmark Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct destinations are the Rab GTPases, a large family of small GTPases that control membrane identity and vesicle budding, uncoating, motility (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2629936 Tue, 14 Jul 2009 23:00:00 +0100 2629936 http://www.medworm.com/index.php?rid=2629935&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2727 Authors: Myriam Hemberger, Wendy Dean & Wolf Reik Cells of the early mammalian embryo, including pluripotent embryonic stem (ES) cells and primordial germ cells (PGCs), are epigenetically dynamic and heterogeneous. During early development, this heterogeneity of epigenetic states is associated with stochastic expression of lineage-determining transcription factors that establish an intimate crosstalk with (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2629935 Tue, 14 Jul 2009 23:00:00 +0100 2629935 http://www.medworm.com/index.php?rid=2629934&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2739 Nature Reviews Molecular Cell Biology 10, 504 (2009). doi:10.1038/nrm2739 Author: Katharine H. Wrighton What do Wnt–β-catenin signalling and telomerase have in common? Both can activate quiescent epidermal stem cells in vivo. However, how telomerase does this, and whether its role in this process is linked to Wnt–β-catenin signalling, was unknown. Steven Artandi and colleagues now reveal (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2629934 Tue, 14 Jul 2009 23:00:00 +0100 2629934 http://www.medworm.com/index.php?rid=2629933&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2737 Nature Reviews Molecular Cell Biology 10, 506 (2009). doi:10.1038/nrm2737 HITS-CLIP hits targetMany efforts to determine microRNA (miRNA) targets rely on computational approaches, which are hampered by high false-positive rates. This problem has been overcome by a recent study, which combined HITS-CLIP (high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation) with bioinformatics to produce (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2629933 Tue, 07 Jul 2009 23:00:00 +0100 2629933 http://www.medworm.com/index.php?rid=2629932&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrm2736 This study not only ascribes new functions to OCT4 that might be important for reprogramming somatic cells to pluripotent cells, but (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=2629932 Tue, 07 Jul 2009 23:00:00 +0100 2629932