Nature Reviews Molecular Cell Biology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nature Reviews Molecular Cell Biology' source. Tue, 07 Feb 2012 08:49:01 +0100 Understanding the language of Lys36 methylation at histone H3 http://www.medworm.com/index.php?rid=5626255&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fq7u4mKTKt34%2Fnrm3274 Authors: Eric J. Wagner & Phillip B. Carpenter Histone side chains are post-translationally modified at multiple sites, including at Lys36 on histone H3 (H3K36). Several enzymes from yeast and humans, including the methyltransferases SET domain-containing 2 (Set2) and nuclear receptor SET domain-containing 1 (NSD1), respectively, alter the methylation status of H3K36, and significant (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626255 Mon, 23 Jan 2012 05:00:00 +0100 5626255 A family business: stem cell progeny join the niche to regulate homeostasis http://www.medworm.com/index.php?rid=5626254&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FZkfemvxlx2g%2Fnrm3272 Authors: Ya-Chieh Hsu & Elaine Fuchs Stem cell niches, the discrete microenvironments in which the stem cells reside, play a dominant part in regulating stem cell activity and behaviours. Recent studies suggest that committed stem cell progeny become indispensable components of the niche in a wide range of stem cell systems. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626254 Mon, 23 Jan 2012 05:00:00 +0100 5626254 How a paper on RAC set the standard http://www.medworm.com/index.php?rid=5626250&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FBchVfWeKXOk%2Fnrm3277 Nature Reviews Molecular Cell Biology 13, 66 (2012). doi:10.1038/nrm3277 Author: Robert Insall An exemplary paper changed the actin field for better and for worse. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626250 Mon, 23 Jan 2012 05:00:00 +0100 5626250 Membrane trafficking: From mitochondria to lysosomes http://www.medworm.com/index.php?rid=5626245&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FJpa8HJX194E%2Fnrm3282 Nature Reviews Molecular Cell Biology 13, 63 (2012). doi:10.1038/nrm3282 Author: Alison Schuldt McBride and colleagues previously observed budding of two vesicle populations from mitochondria, one of which was targeted to peroxisomes. But the fate of the second vesicle pool was unclear. Here, they define the target destination for these vesicles as lysosomes, and thus elucidate a new (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626245 Mon, 23 Jan 2012 05:00:00 +0100 5626245 Cell signalling: A Hippo signal for anoikis http://www.medworm.com/index.php?rid=5626244&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FNsEsDKGmWNg%2Fnrm3281 Nature Reviews Molecular Cell Biology 13, 63 (2012). doi:10.1038/nrm3281 Author: Kim Baumann The Hippo tumour suppressor pathway regulates organ size, but less is known about how the pathway is activated. Zhao et al. show that, in cell cultures, detachment from the extracellular matrix induces cytoplasmic localization and phosphorylation, and thus inactivation, of the transcription co-activator YAP (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626244 Mon, 23 Jan 2012 05:00:00 +0100 5626244 Cytoskeleton: Making multiple cilia http://www.medworm.com/index.php?rid=5626243&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FBAK2M9PWTZk%2Fnrm3280 Nature Reviews Molecular Cell Biology 13, 63 (2012). doi:10.1038/nrm3280 Author: Katharine H. Wrighton How centriole assembly and outgrowth of motile cilia are driven during multiciliate cell (MCC) differentiation is unclear, although Notch signalling is known to inhibit MCC formation in epithelia. Stubbs et al. observed that a gene encoding a small coiled-coiled protein, which they termed multicilin (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626243 Mon, 23 Jan 2012 05:00:00 +0100 5626243 Monkeys show the way http://www.medworm.com/index.php?rid=5626240&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FoQ7V6nx68V8%2Fnrm3278 Nature Reviews Molecular Cell Biology 13, 62 (2012). doi:10.1038/nrm3278 Author: Rachel David The first chimeric non-human primates have been generated in a laboratory in Oregon, USA. The work, which was reported in Cell, gave rise to three rhesus monkeys: Chimero and the twins Roku and Hex.The generation of chimeric mice has been an important tool (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626240 Mon, 23 Jan 2012 05:00:00 +0100 5626240 Stem cells: Self-help in the niche http://www.medworm.com/index.php?rid=5626239&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fe8Uw7r7xffs%2Fnrm3279 Nature Reviews Molecular Cell Biology 13, 61 (2012). doi:10.1038/nrm3279 Author: Kim Baumann Cues from differentiating blood progenitors and the niche can collaborate. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626239 Mon, 23 Jan 2012 05:00:00 +0100 5626239 The unfolded protein response: controlling cell fate decisions under ER stress and beyond http://www.medworm.com/index.php?rid=5626253&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fvj5LXROTfLY%2Fnrm3270 Nature Reviews Molecular Cell Biology 13, 89 (2012). doi:10.1038/nrm3270 Author: Claudio Hetz Protein-folding stress at the endoplasmic reticulum (ER) is a salient feature of specialized secretory cells and is also involved in the pathogenesis of many human diseases. ER stress is buffered by the activation of the unfolded protein response (UPR), a homeostatic signalling network that orchestrates (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626253 Wed, 18 Jan 2012 05:00:00 +0100 5626253 Illuminating the functional and structural repertoire of human TBC/RABGAPs http://www.medworm.com/index.php?rid=5626251&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FraxRaXn1zwQ%2Fnrm3267 Authors: Marieke A. M. Frasa, Katja T. Koessmeier, M. Reza Ahmadian & Vania M. M. Braga The Tre2–Bub2–Cdc16 (TBC) domain-containing RAB-specific GTPase-activating proteins (TBC/RABGAPs) are characterized by the presence of highly conserved TBC domains and act as negative regulators of RABs. The importance of TBC/RABGAPs in the regulation of specific intracellular trafficking routes is now emerging, as is their role in (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626251 Wed, 18 Jan 2012 05:00:00 +0100 5626251 Post-translational modification: A monoubiquitylation pore anchor http://www.medworm.com/index.php?rid=5626249&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FszjmKqfbljk%2Fnrm3276 Nature Reviews Molecular Cell Biology 13, 66 (2012). doi:10.1038/nrm3276 Author: Alison Schuldt Monoubiquitylation of Nup159 recruits dynein and regulates cell division. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626249 Wed, 18 Jan 2012 05:00:00 +0100 5626249 Cell cycle: AMPK moonlights in mitosis http://www.medworm.com/index.php?rid=5626247&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F5ARaT8IPXrE%2Fnrm3275 Nature Reviews Molecular Cell Biology 13, 64 (2012). doi:10.1038/nrm3275 Author: Katharine H. Wrighton Identifies novel AMPKα2 substrates with roles in mitosis. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626247 Wed, 18 Jan 2012 05:00:00 +0100 5626247 Stem cells: Making fat http://www.medworm.com/index.php?rid=5626242&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fz7npOisbpbs%2Fnrm3273 Nature Reviews Molecular Cell Biology 13, 62 (2012). doi:10.1038/nrm3273 Author: Kim Baumann Human pluripotent stem cells are efficiently reprogrammed to white and brown adipocytes. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626242 Wed, 18 Jan 2012 05:00:00 +0100 5626242 Dynamin, a membrane-remodelling GTPase http://www.medworm.com/index.php?rid=5626252&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FheOKb9Z3qYc%2Fnrm3266 Authors: Shawn M. Ferguson & Pietro De Camilli Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events. The use of complementary approaches, including live-cell imaging, cell-free studies, X-ray crystallography and genetic studies in mice, has greatly advanced our (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626252 Wed, 11 Jan 2012 05:00:00 +0100 5626252 RNA decay: Remember your driver http://www.medworm.com/index.php?rid=5626248&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FafLconjqwY8%2Fnrm3271 Nature Reviews Molecular Cell Biology 13, 65 (2012). doi:10.1038/nrm3271 Author: Darren J. Burgess The stability of mRNA can be regulated by the promoter from which it was transcribed. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626248 Wed, 11 Jan 2012 05:00:00 +0100 5626248 Post-translational modification: Inactivating PTP1B upon ER stress http://www.medworm.com/index.php?rid=5626241&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FGyBMP9mImMI%2Fnrm3269 Nature Reviews Molecular Cell Biology 13, 62 (2012). doi:10.1038/nrm3269 Author: Katharine H. Wrighton Sulphydration inhibits the phosphatase activity of PTP1B in response to ER stress. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626241 Thu, 05 Jan 2012 05:00:00 +0100 5626241 Ubiquitylation: DUBs' key to selectivity http://www.medworm.com/index.php?rid=5626246&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FjIJ9WfwJG60%2Fnrm3268 Nature Reviews Molecular Cell Biology 13, 64 (2012). doi:10.1038/nrm3268 Author: Rachel David A UBD containing ankyrin repeats determines the linkage specificity of TRABID. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626246 Fri, 30 Dec 2011 05:00:00 +0100 5626246 Regulating the regulator: post-translational modification of RAS http://www.medworm.com/index.php?rid=5535477&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FqLdHCKLjr6U%2Fnrm3255 Authors: Ian M. Ahearn, Kevin Haigis, Dafna Bar-Sagi & Mark R. Philips RAS proteins are monomeric GTPases that act as binary molecular switches to regulate a wide range of cellular processes. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), which regulate the activation state of (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535477 Thu, 22 Dec 2011 05:00:00 +0100 5535477 Building strong bones: molecular regulation of the osteoblast lineage http://www.medworm.com/index.php?rid=5535476&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fzc7afVCew34%2Fnrm3254 Nature Reviews Molecular Cell Biology 13, 27 (2012). doi:10.1038/nrm3254 Author: Fanxin Long The past 15 years have witnessed tremendous progress in the molecular understanding of osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the major developmental signals (including WNT and Notch signalling), along with an increasing number of transcription factors (such as (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535476 Thu, 22 Dec 2011 05:00:00 +0100 5535476 Microscopy: Easing access to the nanoscale http://www.medworm.com/index.php?rid=5535472&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FPRzKjFJk7TM%2Fnrm3259 Nature Reviews Molecular Cell Biology 13, 6 (2012). doi:10.1038/nrm3259 Author: Kim Baumann A new method for high-resolution imaging using a standard wide-field microscope. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535472 Thu, 22 Dec 2011 05:00:00 +0100 5535472 Plant cell biology: From chloroplast to nucleus http://www.medworm.com/index.php?rid=5535470&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FeKqWiFrNLCQ%2Fnrm3263 Nature Reviews Molecular Cell Biology 13, 5 (2012). doi:10.1038/nrm3263 Author: Kim Baumann Signalling from chloroplasts and mitochondria to the nucleus regulates the expression of nuclear abiotic stress response genes. Estavillo et al. identify PAP (3′-phosphoadenosine 5′-phosphate) as a retrograde signalling molecule. PAP levels increased upon stress, and the phosphatase SAL1, which regulates stress signalling, was shown (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535470 Thu, 22 Dec 2011 05:00:00 +0100 5535470 Cell cycle: Conserved role for RAB5 in mitosis http://www.medworm.com/index.php?rid=5535469&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FoqATXoGkY0E%2Fnrm3262 Nature Reviews Molecular Cell Biology 13, 5 (2012). doi:10.1038/nrm3262 Author: Rachel David The small GTPase RAB5 was recently shown to have a role in mitosis in mammalian cells, and this study demonstrates that this function is conserved in Drosophila melanogaster. The authors find that RAB5 is transported to the spindle poles along astral microtubules in a (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535469 Thu, 22 Dec 2011 05:00:00 +0100 5535469 Cell migration: IAPs targeting RAC1 http://www.medworm.com/index.php?rid=5535468&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FsLhlxaFKLeA%2Fnrm3261 Nature Reviews Molecular Cell Biology 13, 5 (2012). doi:10.1038/nrm3261 Author: Alison Schuldt The RAC1 GTPase can promote elongated cell morphology during cell migration. Here, Oberoi et al. find that the inhibitor of apoptosis (IAP) proteins can directly target RAC1 for proteasomal degradation and that their loss results in increased RAC1 levels, cell elongation and enhanced directed (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535468 Thu, 22 Dec 2011 05:00:00 +0100 5535468 Cell signalling: Crystallizing WNT signalling http://www.medworm.com/index.php?rid=5535464&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FSLGXgDdLKOE%2Fnrm3260 Nature Reviews Molecular Cell Biology 13, 4 (2012). doi:10.1038/nrm3260 Author: Katharine H. Wrighton Structural insight into the DKK1-mediated inhibition of WNT signalling. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535464 Thu, 22 Dec 2011 05:00:00 +0100 5535464 Satellite cells, the engines of muscle repair http://www.medworm.com/index.php?rid=5626256&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FceA7EXAFm4k%2Fnrm3265 Authors: Yu Xin Wang & Michael A. Rudnicki Satellite cells are a heterogeneous population of stem and progenitor cells that are required for the growth, maintenance and regeneration of skeletal muscle. The transcription factors paired-box 3 (PAX3) and PAX7 have essential and overlapping roles in myogenesis. PAX3 acts to specify embryonic muscle precursors, (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5626256 Wed, 21 Dec 2011 05:00:00 +0100 5626256 Canonical and non-canonical autophagy: variations on a common theme of self-eating? http://www.medworm.com/index.php?rid=5535473&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FEC8JXocBM-Y%2Fnrm3249 Authors: Patrice Codogno, Maryam Mehrpour & Tassula Proikas-Cezanne The autophagosome is the central organelle in macroautophagy, a vacuolar lysosomal catabolic pathway that degrades cytoplasmic material to fuel starving cells and eliminates intracellular pathogens. Macroautophagy has important physiological roles during development, ageing and the immune response, and its cytoprotective function is compromised in various (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535473 Wed, 14 Dec 2011 05:00:00 +0100 5535473 Nucleoskeleton: Uncovering roles for lamin B http://www.medworm.com/index.php?rid=5535463&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FP-ttvl944bc%2Fnrm3257 Nature Reviews Molecular Cell Biology 13, 3 (2012). doi:10.1038/nrm3257 Author: Rachel David Two studies reveal roles for B-type lamins in organogenesis and cell proliferation. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535463 Wed, 14 Dec 2011 05:00:00 +0100 5535463 Cytoskeleton: A stabilizing influence for K-fibres http://www.medworm.com/index.php?rid=5535462&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F-LCTLCBvx_E%2Fnrm3256 Nature Reviews Molecular Cell Biology 13, 2 (2012). doi:10.1038/nrm3256 Author: Antony F. Bickenson MCRS1 stabilizes K-fibres and spindle assembly in a RAN·GTP-dependent manner. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535462 Wed, 14 Dec 2011 05:00:00 +0100 5535462 Gene expression: An ncRNA relocation package http://www.medworm.com/index.php?rid=5535460&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F3LkYVtjnf6U%2Fnrm3258 Nature Reviews Molecular Cell Biology 13, 1 (2012). doi:10.1038/nrm3258 Author: Alison Schuldt ncRNAs regulate gene localization between distinct nuclear subcompartments. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535460 Wed, 14 Dec 2011 05:00:00 +0100 5535460 Walking to work: roles for class V myosins as cargo transporters http://www.medworm.com/index.php?rid=5535475&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F4T03Z9MCuEI%2Fnrm3248 Authors: John A. Hammer & James R. Sellers Cells use molecular motors, such as myosins, to move, position and segregate their organelles. Class V myosins possess biochemical and structural properties that should make them ideal actin-based cargo transporters. Indeed, studies show that class V myosins function as cargo transporters in yeast, moving a (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535475 Wed, 07 Dec 2011 05:00:00 +0100 5535475 Dynamic niches in the origination and differentiation of haematopoietic stem cells http://www.medworm.com/index.php?rid=5535474&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FqQOAhf3EHWM%2Fnrm3245 Nature Reviews Molecular Cell Biology 13, 12 (2012). doi:10.1038/nrm3245 Author: Leo D. Wang & Amy J. Wagers Nature Reviews Molecular Cell Biology12, 643–655 (2011)The authors wish to correct two typographical errors in the above article. On page 654, there was an error in the highlighted reference comment. The text “References 74–76 and 103 use (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535474 Wed, 07 Dec 2011 05:00:00 +0100 5535474 Stem cells: Stem cells follow the clock http://www.medworm.com/index.php?rid=5535466&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F25ejJl5-gn4%2Fnrm3253 Nature Reviews Molecular Cell Biology 13, 4 (2012). doi:10.1038/nrm3253 Author: Kim Baumann Epidermal stem cell activity is directly regulated by core clock proteins. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535466 Wed, 07 Dec 2011 05:00:00 +0100 5535466 Organelle dynamics: Stopping mitochondria in their tracks http://www.medworm.com/index.php?rid=5535465&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FRdw4aTpO5w8%2Fnrm3251 Nature Reviews Molecular Cell Biology 13, 4 (2012). doi:10.1038/nrm3251 Author: Katharine H. Wrighton PINK1 phosphorylates MIRO; parkin then degrades MIRO to halt mitochondrial movement. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535465 Wed, 07 Dec 2011 05:00:00 +0100 5535465 Cell migration: H2O2 sensing: the missing 'Lynk' http://www.medworm.com/index.php?rid=5535461&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FRyMRVgiv-jo%2Fnrm3250 Nature Reviews Molecular Cell Biology 13, 2 (2012). doi:10.1038/nrm3250 Author: Mhairi Skinner Lyn senses H2O2 at wound sites and mediates neutrophil migration. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535461 Wed, 07 Dec 2011 05:00:00 +0100 5535461 Is chromatin helical? http://www.medworm.com/index.php?rid=5535471&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FZWIhXEBjtDA%2Fnrm3247 Nature Reviews Molecular Cell Biology 13, 6 (2012). doi:10.1038/nrm3247 Author: Thoru Pederson Discusses recent papers on the topography of the interphase chromatin fibre. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535471 Wed, 30 Nov 2011 05:00:00 +0100 5535471 Plant cell biology: Sensing oxygen http://www.medworm.com/index.php?rid=5535467&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FZdXV59UIAzc%2Fnrm3252 Nature Reviews Molecular Cell Biology 13, 5 (2012). doi:10.1038/nrm3252 Author: Kim Baumann Nature Reviews Molecular Cell Biology  12, 770 (2011)There was an error in the definition of ERF: "EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR" should have read "ETHYLENE RESPONSE FACTOR". This has been corrected Online. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535467 Wed, 30 Nov 2011 05:00:00 +0100 5535467 Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles http://www.medworm.com/index.php?rid=5535478&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fp9O56krRXb4%2Fnrm3244 Authors: Radek Dobrowolski & Edward M. De Robertis Signal transduction and endocytosis are intertwined processes. The internalization of ligand-activated receptors by endocytosis has classically been thought to attenuate signals by targeting receptors for degradation in lysosomes, but it can also maintain signals in early signalling endosomes. In both cases, localization to multivesicular endosomesen (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5535478 Wed, 23 Nov 2011 05:00:00 +0100 5535478 All tangled up: how cells direct, manage and exploit topoisomerase function http://www.medworm.com/index.php?rid=5438913&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fa0m4bSAgbaI%2Fnrm3228 Authors: Seychelle M. Vos, Elsa M. Tretter, Bryan H. Schmidt & James M. Berger Topoisomerases are complex molecular machines that modulate DNA topology to maintain chromosome superstructure and integrity. Although capable of stand-alone activity in vitro, topoisomerases are frequently linked to larger pathways and systems that resolve specific DNA superstructures and intermediates arising from cellular processes such as (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438913 Wed, 23 Nov 2011 05:00:00 +0100 5438913 Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control http://www.medworm.com/index.php?rid=5438912&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FIXG1USF1MnA%2Fnrm3231 Nature Reviews Molecular Cell Biology 12, 815 (2011). doi:10.1038/nrm3231 Author: Jeannie T. Lee The discovery of X-chromosome inactivation (XCI) celebrated its golden anniversary this year. Originally offered as an explanation for the establishment of genetic equality between males and females, 50 years on, XCI presents more than a curious gender-based phenomenon that causes silencing of sex chromosomes. How (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438912 Wed, 23 Nov 2011 05:00:00 +0100 5438912 Trithorax group proteins: switching genes on and keeping them active http://www.medworm.com/index.php?rid=5438911&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FRYWEsG_hEp8%2Fnrm3230 Authors: Bernd Schuettengruber, Anne-Marie Martinez, Nicola Iovino & Giacomo Cavalli Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein MLL in leukaemia. However, in terms of molecular (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438911 Wed, 23 Nov 2011 05:00:00 +0100 5438911 Mechanisms of disease: p53 puts a damper on WNT signalling http://www.medworm.com/index.php?rid=5438906&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FITYmHnrrhe8%2Fnrm3238 Nature Reviews Molecular Cell Biology 12, 770 (2011). doi:10.1038/nrm3238 Author: Katharine H Wrighton Kim et al. reveal why loss of the p53 tumour suppressor protein correlates with the activation of WNT signalling in cancer. During WNT signalling, WNT stabilizes β-catenin, which forms a complex with T cell factor and lymphoid enhancer factor (TCF/LEF)-family transcription factors. Here, the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438906 Wed, 23 Nov 2011 05:00:00 +0100 5438906 Cell polarity: A scaffolding spindle guide http://www.medworm.com/index.php?rid=5438905&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fs6Rcl5WmhPE%2Fnrm3237 Nature Reviews Molecular Cell Biology 12, 770 (2011). doi:10.1038/nrm3237 Author: Alison Schuldt During asymmetric cell division in Drosophila melanogaster neuroblasts, Partner of Inscuteable (PINS) at the apical cortex mediates spindle orientation through two pathways, one of which requires MUD (Mushroom body defect). Wee et al. reveal that the scaffolding protein Canoe (called afadin or AF6 (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438905 Wed, 23 Nov 2011 05:00:00 +0100 5438905 Telomeres: A template trigger for translocation http://www.medworm.com/index.php?rid=5438904&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FxS_oTAZ8jlw%2Fnrm3236 Nature Reviews Molecular Cell Biology 12, 770 (2011). doi:10.1038/nrm3236 Author: Alison Schuldt The telomerase ribonucleoprotein enzyme maintains eukaryotic chromosomes through unique means. Its telomerase reverse transcriptase (TERT) enzymatic subunit synthesizes telomeric DNA repeats from the template RNA subunit (TER) by 'repeat addition processivity'. How telomerase recycles this internal template, and how the template progresses through the TERT (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438904 Wed, 23 Nov 2011 05:00:00 +0100 5438904 Plant cell biology: Sensing oxygen http://www.medworm.com/index.php?rid=5438903&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FeN9Lf6SbeLs%2Fnrm3235 Nature Reviews Molecular Cell Biology 12, 770 (2011). doi:10.1038/nrm3235 Author: Kim Baumann The N-end rule degradation pathway is part of the oxygen-sensing mechanism in plants. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438903 Wed, 23 Nov 2011 05:00:00 +0100 5438903 Stem cells: Having the guts to grow http://www.medworm.com/index.php?rid=5438901&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F3v4APXdSkFI%2Fnrm3233 Nature Reviews Molecular Cell Biology 12, 768 (2011). doi:10.1038/nrm3233 Author: Kim Baumann Symmetric intestinal stem cell division drives adaptive midgut growth. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438901 Wed, 23 Nov 2011 05:00:00 +0100 5438901 Development: Osteoblasts and osteoclasts keep in touch http://www.medworm.com/index.php?rid=5438899&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FCiCJQFpHSkQ%2Fnrm3241 This study reveals that semaphorin 4D expressed by osteoclasts is integral to the communication between the two cell types. Using in vitro assays and genetic mouse (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438899 Wed, 23 Nov 2011 05:00:00 +0100 5438899 Cell cycle: A new role for RAB5 http://www.medworm.com/index.php?rid=5438898&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FfHkhls_bLXQ%2Fnrm3240 This study shows that the small GTPase RAB5, which is known to regulate early steps of endocytosis, also plays a part in mitosis. Depletion of RAB5 by RNA interference in human cell lines led to impaired chromosome congression and delayed nuclear envelope disassembly. Chromosome movements (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438898 Wed, 23 Nov 2011 05:00:00 +0100 5438898 Systems biology: Scaling in flies http://www.medworm.com/index.php?rid=5438897&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FR_aaS7fTo7o%2Fnrm3239 Nature Reviews Molecular Cell Biology 12, 767 (2011). doi:10.1038/nrm3239 Author: Kim Baumann How scaling, the process of expanding proportionally, occurs during development is not well understood. Using the Drosophila melanogaster wing as a model to study scaling quantitatively, Affolter and colleagues examined whether the activity gradient of the morphogen Decapentaplegic (DPP) scales during imaginal disc growth. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438897 Wed, 23 Nov 2011 05:00:00 +0100 5438897 From the editors http://www.medworm.com/index.php?rid=5438894&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FKHl8PRTaBJM%2Fnrm3242 Nature Reviews Molecular Cell Biology 12, 765 (2011). doi:10.1038/nrm3242 This issue features a Review by Jeannie T. Lee (page 815) to celebrate the golden anniversary of research on X-chromosome inactivation (XCI). Major progress has been made in the field following the first suggestion, 50 years ago, that one X chromosome in every (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438894 Wed, 23 Nov 2011 05:00:00 +0100 5438894 Tail-anchored membrane protein insertion into the endoplasmic reticulum http://www.medworm.com/index.php?rid=5438910&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FNOZAoOoIwuY%2Fnrm3226 Authors: Ramanujan S. Hegde & Robert J. Keenan Membrane proteins are inserted into the endoplasmic reticulum (ER) by two highly conserved parallel pathways. The well-studied co-translational pathway uses signal recognition particle (SRP) and its receptor for targeting and the SEC61 translocon for membrane integration. A recently discovered post-translational pathway uses an entirely different (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438910 Wed, 16 Nov 2011 05:00:00 +0100 5438910 Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions http://www.medworm.com/index.php?rid=5438909&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FLiCz2L3RUY0%2Fnrm3227 Authors: Carsten Janke & Jeannette Chloë Bulinski Half a century of biochemical and biophysical experiments has provided attractive models that may explain the diverse functions of microtubules within cells and organisms. However, the notion of functionally distinct microtubule types has not been explored with similar intensity, mostly because mechanisms for generating divergent (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438909 Wed, 16 Nov 2011 05:00:00 +0100 5438909 Development: Autophagy eliminates paternal mitochondria http://www.medworm.com/index.php?rid=5438908&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FCc2FbVezQ8k%2Fnrm3234 Nature Reviews Molecular Cell Biology 12, 771 (2011). doi:10.1038/nrm3234 Author: Katharine H. Wrighton Paternal mitochondria are degraded by fertilization-induced autophagy. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438908 Wed, 16 Nov 2011 05:00:00 +0100 5438908 Cell cycle: E2F1 ensures the endocycle http://www.medworm.com/index.php?rid=5438900&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F5_sc4WWAJQA%2Fnrm3232 Nature Reviews Molecular Cell Biology 12, 768 (2011). doi:10.1038/nrm3232 Author: Alison Schuldt E2F1 oscillations control endocycle progression in Drosophila melanogaster. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438900 Wed, 16 Nov 2011 05:00:00 +0100 5438900 Cell signalling: mTOR targets its own inhibitor http://www.medworm.com/index.php?rid=5438902&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F2D-VW2MVAIE%2Fnrm3229 Nature Reviews Molecular Cell Biology 12, 769 (2011). doi:10.1038/nrm3229 Author: Katharine H. Wrighton The ubiquitin E3 ligase SCFβTrCP targets the mTOR inhibitor DEPTOR for degradation. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438902 Wed, 09 Nov 2011 05:00:00 +0100 5438902 RNA: A new layer of regulation http://www.medworm.com/index.php?rid=5438895&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F7ad5xwJwMhw%2Fnrm3225 Nature Reviews Molecular Cell Biology 12, 766 (2011). doi:10.1038/nrm3225 Author: Rachel David Four studies reveal the existence of ceRNAs, which regulate each other's expression. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438895 Thu, 03 Nov 2011 04:00:00 +0100 5438895 Cell death: The single-membrane diet http://www.medworm.com/index.php?rid=5438896&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FzKS1RGDdXTo%2Fnrm3224 Nature Reviews Molecular Cell Biology 12, 767 (2011). doi:10.1038/nrm3224 Author: Antony F. Bickenson Autophagy proteins function in a non-canonical single-membrane vesicle degradation pathway. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438896 Thu, 27 Oct 2011 04:00:00 +0100 5438896 It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival http://www.medworm.com/index.php?rid=5344960&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F8lF5kdWifqw%2Fnrm3214 Authors: Andrew Oberst & Douglas R. Green Caspase 8 can initiate apoptosis, but it also has non-apoptotic roles; for example, it is required for embryonic development and immune cell proliferation. Recent work has indicated that the requirement for caspase 8 in development and immune cell proliferation is defined by suppression of receptor-interacting (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344960 Fri, 21 Oct 2011 04:00:00 +0100 5344960 Imaging the coordination of multiple signalling activities in living cells http://www.medworm.com/index.php?rid=5344959&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F9E8YRM-sjcg%2Fnrm3212 Authors: Christopher M. Welch, Hunter Elliott, Gaudenz Danuser & Klaus M. Hahn Cellular signal transduction occurs in complex and redundant interaction networks, which are best understood by simultaneously monitoring the activation dynamics of multiple components. Recent advances in biosensor technology have made it possible to visualize and quantify the activation of multiple network nodes in the same (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344959 Fri, 21 Oct 2011 04:00:00 +0100 5344959 The N-end rule pathway: emerging functions and molecular principles of substrate recognition http://www.medworm.com/index.php?rid=5344958&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FW_5WbCSWY28%2Fnrm3217 Authors: Shashikanth M. Sriram, Bo Yeon Kim & Yong Tae Kwon The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue and its post-translational modification. Since its discovery 25 years ago, the pathway involved in the N-end rule has been thought to target only a limited set of specific substrates of the ubiquitin–proteasome system. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344958 Fri, 21 Oct 2011 04:00:00 +0100 5344958 Circadian rhythms: Modifying the clock http://www.medworm.com/index.php?rid=5344954&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FIFVeGPn0pig%2Fnrm3222 Nature Reviews Molecular Cell Biology 12, 693 (2011). doi:10.1038/nrm3222 Author: Kim Baumann The circadian clock is controlled by a transcription–translation circuit that revolves around the transcription factors CLOCK and BMAL1. Chromatin modifications are important for maintaining circadian rhythms, but their precise role and how they are regulated remains unclear. DiTacchio et al. find that the histone (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344954 Fri, 21 Oct 2011 04:00:00 +0100 5344954 Gene expression: An importin-α stress response http://www.medworm.com/index.php?rid=5344953&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FbZaJoLITGIU%2Fnrm3221 Nature Reviews Molecular Cell Biology 12, 693 (2011). doi:10.1038/nrm3221 Author: Alison Schuldt Nuclear import is facilitated by carrier proteins of the importin family, with importin-α acting as an adaptor that mediates the association of cargo with importin β1. In response to stress, importin-α rapidly accumulates in the nucleus, and Yoneda and colleagues have found that it has (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344953 Fri, 21 Oct 2011 04:00:00 +0100 5344953 Cell polarity: PAR access control http://www.medworm.com/index.php?rid=5344952&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FAjbBHkXZmJk%2Fnrm3220 Nature Reviews Molecular Cell Biology 12, 693 (2011). doi:10.1038/nrm3220 Author: Alison Schuldt The Caenorhabditis elegans zygote rapidly establishes regional domains of partitioning defective (PAR) polarity factors along the anterior–posterior axis. Microtubules can affect this, and Seydoux and colleagues now show that this is through microtubule-mediated local protection of PAR-2. Contact of the sperm centrosome, a microtubule-organizing (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344952 Fri, 21 Oct 2011 04:00:00 +0100 5344952 Reprogramming revitalized http://www.medworm.com/index.php?rid=5344950&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FpiubqgwZB1k%2Fnrm3219 Nature Reviews Molecular Cell Biology 12, 692 (2011). doi:10.1038/nrm3219 Author: Rachel David Somatic cell nuclear transfer has been used successfully for the first time to generate human pluripotent stem cells.Although nuclear transfer has been successfully used to generate stem cells in other species, including mice and sheep, human oocytes manipulated through nuclear transfer arrested before the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344950 Fri, 21 Oct 2011 04:00:00 +0100 5344950 Ageing: A midlife crisis for sirtuins http://www.medworm.com/index.php?rid=5344943&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FOirnqp_7pFw%2Fnrm3218 Nature Reviews Molecular Cell Biology 12, 688 (2011). doi:10.1038/nrm3218 Author: Kim Baumann New findings challenge the idea that sirtuins promote longevity. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344943 Fri, 21 Oct 2011 04:00:00 +0100 5344943 From the editors http://www.medworm.com/index.php?rid=5344942&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FN4ZpHuMK0u8%2Fnrm3223 Nature Reviews Molecular Cell Biology 12, 687 (2011). doi:10.1038/nrm3223 This month, we have a group of articles that shed light on the dynamic architectural networks of the cell, the cytoskeleton and the nucleoskeleton. A key step in controlling the dynamics of microtubules, which are integral components of the cytoskeleton, is the nucleation of new (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344942 Fri, 21 Oct 2011 04:00:00 +0100 5344942 Microtubule nucleation by γ-tubulin complexes http://www.medworm.com/index.php?rid=5344956&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FiSXdeGl2Oqk%2Fnrm3209 Authors: Justin M. Kollman, Andreas Merdes, Lionel Mourey & David A. Agard Microtubule nucleation is regulated by the γ-tubulin ring complex (γTuRC) and related γ-tubulin complexes, providing spatial and temporal control over the initiation of microtubule growth. Recent structural work has shed light on the mechanism of γTuRC-based microtubule nucleation, confirming the long-standing hypothesis that the γTuRC (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344956 Wed, 12 Oct 2011 04:00:00 +0100 5344956 Organelle dynamics: Inheritance for pluripotency http://www.medworm.com/index.php?rid=5344947&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FQJkv5MGKyJ8%2Fnrm3216 Nature Reviews Molecular Cell Biology 12, 690 (2011). doi:10.1038/nrm3216 Author: Kim Baumann Midbodies promote stem cell pluripotency and cancer tumorigenicity. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344947 Wed, 12 Oct 2011 04:00:00 +0100 5344947 DNA repair: Nuclear receptors in repair http://www.medworm.com/index.php?rid=5344946&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FayguIZ7OFCI%2Fnrm3215 Nature Reviews Molecular Cell Biology 12, 690 (2011). doi:10.1038/nrm3215 Author: Alison Schuldt NR4A proteins regulate DNA double-strand break repair independently of transcription. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344946 Wed, 12 Oct 2011 04:00:00 +0100 5344946 Cell signalling: PRMT5 restricts ERK activity http://www.medworm.com/index.php?rid=5344945&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FS-yQy49ktyU%2Fnrm3213 Nature Reviews Molecular Cell Biology 12, 689 (2011). doi:10.1038/nrm3213 Author: Katharine H. Wrighton PRMT5 methylates RAF proteins to decrease their stability and reduce ERK activation. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344945 Wed, 12 Oct 2011 04:00:00 +0100 5344945 Localizing cellular housekeeping http://www.medworm.com/index.php?rid=5438907&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FQ8yL94huW4Q%2Fnrm3206 Nature Reviews Molecular Cell Biology 12, 771 (2011). doi:10.1038/nrm3206 Author: Peter L. Hordijk Describes how proteins are often synthesized and degraded at their site of action. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5438907 Wed, 05 Oct 2011 04:00:00 +0100 5438907 The nucleoskeleton as a genome-associated dynamic 'network of networks' http://www.medworm.com/index.php?rid=5344955&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F4e2iGkC1mkw%2Fnrm3207 Authors: Dan N. Simon & Katherine L. Wilson In the cytosol, actin polymers, intermediate filaments and microtubules can anchor to cell surface adhesions and interlink to form intricate networks. This cytoskeleton is anchored to the nucleus through LINC (links the nucleoskeleton and cytoskeleton) complexes that span the nuclear envelope and in turn anchor (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344955 Wed, 05 Oct 2011 04:00:00 +0100 5344955 Stem cells: The 'backup' intestinal stem cell http://www.medworm.com/index.php?rid=5344949&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F9El34LZ0ycg%2Fnrm3211 Nature Reviews Molecular Cell Biology 12, 692 (2011). doi:10.1038/nrm3211 Author: Rachel David Slower-cycling stem cells compensate for LGR5-expressing crypt base columnar cells. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344949 Wed, 05 Oct 2011 04:00:00 +0100 5344949 Mechanisms of disease: USP1 keeps ID proteins stable http://www.medworm.com/index.php?rid=5344948&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FH7e4at2ZCSg%2Fnrm3210 Nature Reviews Molecular Cell Biology 12, 691 (2011). doi:10.1038/nrm3210 Author: Katharine H. Wrighton USP1 stabilizes ID proteins to inhibit differentiation in MSCs and osteosarcoma. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344948 Wed, 05 Oct 2011 04:00:00 +0100 5344948 Forming functional fat: a growing understanding of adipocyte differentiation http://www.medworm.com/index.php?rid=5344957&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FeaSvE1ADQbs%2Fnrm3198 Authors: Ana G. Cristancho & Mitchell A. Lazar Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy and metabolic homeostasis. Adipogenesis is thought to occur in two stages: commitment of mesenchymal stem cells to a preadipocyte fate and terminal differentiation. Cell shape and extracellular matrix remodelling have recently been (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344957 Wed, 28 Sep 2011 04:00:00 +0100 5344957 Chromatin: Chromatin state reaches out http://www.medworm.com/index.php?rid=5344951&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fc5ZB1YUQXw0%2Fnrm3208 Nature Reviews Molecular Cell Biology 12, 692 (2011). doi:10.1038/nrm3208 Author: Antony F. Bickenson Shows crosstalk between histone H2B ubiquitylation and Dam1 methylation at kinetochores. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344951 Wed, 28 Sep 2011 04:00:00 +0100 5344951 Deconstructing the cell cycle http://www.medworm.com/index.php?rid=5344944&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FJXzYvml1_68%2Fnrm3205 Nature Reviews Molecular Cell Biology 12, 689 (2011). doi:10.1038/nrm3205 Author: Sophie Martin Describes how a minimal oscillatory cyclin–CDK module can drive the cell cycle. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5344944 Wed, 28 Sep 2011 04:00:00 +0100 5344944 Discovering pluripotency: 30 years of mouse embryonic stem cells http://www.medworm.com/index.php?rid=5247789&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FyKltAhZ49kE%2Fnrm3190 Nature Reviews Molecular Cell Biology 12, 680 (2011). doi:10.1038/nrm3190 Author: Martin Evans Embryonic stem (ES) cells are pluripotent cells isolated from an early embryo and grown as a cell line in tissue culture. Their discovery came from the conjunction of studies in human pathology, mouse genetics, early mouse embryo development, cell surface immunology and tissue culture. ES (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247789 Fri, 23 Sep 2011 04:00:00 +0100 5247789 A decade of molecular cell biology: achievements and challenges http://www.medworm.com/index.php?rid=5247787&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FSk72tU-BuZE%2Fnrm3187 Authors: Asifa Akhtar, Elaine Fuchs, Tim Mitchison, Reuben J. Shaw, Daniel St Johnston, Andreas Strasser, Susan Taylor, Claire Walczak & Marino Zerial Nature Reviews Molecular Cell Biology celebrated its 10-year anniversary during this past year with a series of specially commissioned articles. To complement this, here we have asked researchers from across the field for their insights into how molecular cell biology research has evolved during (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247787 Fri, 23 Sep 2011 04:00:00 +0100 5247787 Proteins on the move: insights gained from fluorescent protein technologies http://www.medworm.com/index.php?rid=5247786&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FSPGZP-K_nkA%2Fnrm3199 Nature Reviews Molecular Cell Biology 12, 656 (2011). doi:10.1038/nrm3199 Author: Atsushi Miyawaki Proteins are always on the move, and this may occur through diffusion or active transport. The realization that the regulation of signal transduction is highly dynamic in space and time has stimulated intense interest in the movement of proteins. Over the past decade, numerous new (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247786 Fri, 23 Sep 2011 04:00:00 +0100 5247786 Membrane dynamics: ER marks the spot http://www.medworm.com/index.php?rid=5247783&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FeXGFTivZA_Y%2Fnrm3200 Nature Reviews Molecular Cell Biology 12, 627 (2011). doi:10.1038/nrm3200 Author: Alison Schuldt ER contact with mitochondria positions mitochondrial constriction and fission. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247783 Fri, 23 Sep 2011 04:00:00 +0100 5247783 In brief http://www.medworm.com/index.php?rid=5247781&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FT3M5o3Bhois%2Fnrm3202 Nature Reviews Molecular Cell Biology 12, 626 (2011). doi:10.1038/nrm3202 Cell signallingMindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signalingBerndt, J. D.et al. J. Cell Biol.194, 737–750 (2011)ArticleIn addition to Frizzled receptors, WNT signalling can (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247781 Fri, 23 Sep 2011 04:00:00 +0100 5247781 Cell division: CENPA's tail rules the centromere http://www.medworm.com/index.php?rid=5247780&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fuph0H-D8Jd4%2Fnrm3196 Nature Reviews Molecular Cell Biology 12, 626 (2011). doi:10.1038/nrm3196 Author: Joanna E. Huddleston An in vitro system shows the C-terminal tail of CENPA is sufficient for centromere assembly. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247780 Fri, 23 Sep 2011 04:00:00 +0100 5247780 Structure watch http://www.medworm.com/index.php?rid=5247776&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F4mFFTxxo4_o%2Fnrm3203 Nature Reviews Molecular Cell Biology 12, 623 (2011). doi:10.1038/nrm3203 Deconstructing dynaminDynamin-related proteins (DRPs) are multidomain GTPases that can regulate membrane remodelling events. Although DRPs are known to undergo oligomerization and GTP-dependent conformational changes, it is less clear how these properties drive membrane remodelling.Ford et al. determined the crystal structure of a (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247776 Fri, 23 Sep 2011 04:00:00 +0100 5247776 From the editors http://www.medworm.com/index.php?rid=5247773&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FNCjgnJmv204%2Fnrm3201 Nature Reviews Molecular Cell Biology 12, 621 (2011). doi:10.1038/nrm3201 This year marks the thirtieth anniversary since embryonic stem (ES) cells were first isolated from mouse blastocysts. We celebrate this with a Poster that provides a timeline overview of the history of research on pluripotency, starting from early studies of teratocarcinomas, which preceded the isolation (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247773 Fri, 23 Sep 2011 04:00:00 +0100 5247773 Insights into autotaxin: how to produce and present a lipid mediator http://www.medworm.com/index.php?rid=5247788&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fsc2FeBfOYOo%2Fnrm3188 Authors: Wouter H. Moolenaar & Anastassis Perrakis Autotaxin (ATX) is a secreted phosphodiesterase that produces the lipid mediator lysophosphatidic acid (LPA). LPA acts through specific guanine-nucleotide-binding protein (G protein)-coupled receptors to stimulate migration, proliferation, survival and other functions in many cell types. ATX is important in vivo for processes as diverse (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247788 Wed, 14 Sep 2011 04:00:00 +0100 5247788 Deciphering arginine methylation: Tudor tells the tale http://www.medworm.com/index.php?rid=5247784&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FJ69onJc4pJI%2Fnrm3185 Authors: Chen Chen, Timothy J. Nott, Jing Jin & Tony Pawson Proteins can be modified by post-translational modifications such as phosphorylation, methylation, acetylation and ubiquitylation, creating binding sites for specific protein domains. Methylation has pivotal roles in the formation of complexes that are involved in cellular regulation, including in the generation of small RNAs. Arginine methylation (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247784 Wed, 14 Sep 2011 04:00:00 +0100 5247784 Cell death: Linking metabolism to apoptotic sensitivity http://www.medworm.com/index.php?rid=5247779&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FuO_cAV6Spcw%2Fnrm3195 Nature Reviews Molecular Cell Biology 12, 625 (2011). doi:10.1038/nrm3195 Author: Katharine H. Wrighton BCL-XL suppresses acetyl CoA production to protect cells against apoptosis. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247779 Wed, 14 Sep 2011 04:00:00 +0100 5247779 Cell division: Repo-Man's extra exit strategy http://www.medworm.com/index.php?rid=5247778&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FhVdU2pP8uOc%2Fnrm3197 Nature Reviews Molecular Cell Biology 12, 624 (2011). doi:10.1038/nrm3197 Author: Antony F. Bickenson Repo-Man has a role in both chromatin remodelling and nuclear envelope reformation. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247778 Wed, 14 Sep 2011 04:00:00 +0100 5247778 Cell cycle: The division belt http://www.medworm.com/index.php?rid=5247774&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FQle5zrodMFQ%2Fnrm3194 Nature Reviews Molecular Cell Biology 12, 622 (2011). doi:10.1038/nrm3194 Author: Kim Baumann Chromosomes align into an equatorial ring prior to bi-orientation. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247774 Wed, 14 Sep 2011 04:00:00 +0100 5247774 The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation http://www.medworm.com/index.php?rid=5247790&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FKkmuax61FKU%2Fnrm3191 Nature Reviews Molecular Cell Biology 12, 686 (2011). doi:10.1038/nrm3191 Author: Allan M. Weissman, Nitzan Shabek & Aaron Ciechanover Nature Reviews Molecular Cell Biology12, 605–620 (2011)On page 619 of the above article, there was a mistake in the highlighted reference comment under reference 54: "53" in the second sentence should have been "54" ("Reference 54 is (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247790 Wed, 07 Sep 2011 04:00:00 +0100 5247790 Cell death: Phagocytes whet their appetite http://www.medworm.com/index.php?rid=5247782&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F50ho0eGRoNY%2Fnrm3192 Nature Reviews Molecular Cell Biology 12, 627 (2011). doi:10.1038/nrm3192 Author: Rachel David Mitochondrial membrane potential regulates a cell's phagocytic ability. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247782 Wed, 07 Sep 2011 04:00:00 +0100 5247782 Chromatin: Stress inhibits replication through JNK1 signalling http://www.medworm.com/index.php?rid=5247775&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FqBSl8r8Fhjc%2Fnrm3193 Nature Reviews Molecular Cell Biology 12, 623 (2011). doi:10.1038/nrm3193 Author: Joanna E. Huddleston Stress-induced phosphorylation of CDT1 by JNK1 prevents HBO1 recruitment to inhibit replication. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247775 Wed, 07 Sep 2011 04:00:00 +0100 5247775 Dynamic niches in the origination and differentiation of haematopoietic stem cells http://www.medworm.com/index.php?rid=5247785&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FEb9pjOPnZjg%2Fnrm3184 Authors: Leo D. Wang & Amy J. Wagers Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate all mature blood cells. HSC function is tightly controlled to maintain haematopoietic homeostasis, and this regulation relies on specialized cells and factors that constitute the haematopoietic 'niche', or microenvironment. Recent discoveries, aided in part by (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247785 Fri, 02 Sep 2011 04:00:00 +0100 5247785 Telomeres: Fusing with RNF8 http://www.medworm.com/index.php?rid=5247777&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F-0FiAxyZxYQ%2Fnrm3186 Nature Reviews Molecular Cell Biology 12, 624 (2011). doi:10.1038/nrm3186 Author: Rachel David RNF8 promotes the fusion of uncapped telomeres through ubiquitylation. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5247777 Fri, 02 Sep 2011 04:00:00 +0100 5247777 The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation http://www.medworm.com/index.php?rid=5158269&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FWib2BtAd17w%2Fnrm3173 Authors: Allan M. Weissman, Nitzan Shabek & Aaron Ciechanover Ubiquitylation (also known as ubiquitination) regulates essentially all of the intracellular processes in eukaryotes through highly specific modification of numerous cellular proteins, which is often tightly regulated in a spatial and temporal manner. Although most often associated with proteasomal degradation, ubiquitylation frequently serves non-proteolytic functions. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158269 Mon, 22 Aug 2011 23:00:00 +0100 5158269 Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis http://www.medworm.com/index.php?rid=5158266&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fnn3JyzYbE00%2Fnrm3175 Authors: Cory L. Simpson, Dipal M. Patel & Kathleen J. Green To provide a stable environmental barrier, the epidermis requires an integrated network of cytoskeletal elements and cellular junctions. Nevertheless, the epidermis ranks among the body's most dynamic tissues, continually regenerating itself and responding to cutaneous insults. As keratinocytes journey from the basal compartment towards the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158266 Mon, 22 Aug 2011 23:00:00 +0100 5158266 Molecular control of endothelial cell behaviour during blood vessel morphogenesis http://www.medworm.com/index.php?rid=5158265&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FiNgMl2zscR8%2Fnrm3176 Authors: Shane P. Herbert & Didier Y. R. Stainier The vertebrate vasculature forms an extensive branched network of blood vessels that supplies tissues with nutrients and oxygen. During vascular development, coordinated control of endothelial cell behaviour at the levels of cell migration, proliferation, polarity, differentiation and cell–cell communication is critical for functional blood vessel (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158265 Mon, 22 Aug 2011 23:00:00 +0100 5158265 Cell signalling: JH2 is active! http://www.medworm.com/index.php?rid=5158264&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FEi9RBRm6qZ8%2Fnrm3183 Nature Reviews Molecular Cell Biology 12, 550 (2011). doi:10.1038/nrm3183 Author: Kim Baumann The kinase activity of the JAK2 JH2 domain inhibits JAK2. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158264 Mon, 22 Aug 2011 23:00:00 +0100 5158264 In brief http://www.medworm.com/index.php?rid=5158261&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F2ugvlbLKXvw%2Fnrm3181 Nature Reviews Molecular Cell Biology 12, 549 (2011). doi:10.1038/nrm3181 DevelopmentNotch and Ras promote sequential steps of excretory tube development in C. elegansAbdus-Saboor, I.Development138, 3545–3555 (2011)ArticleThe excretory organ in Caenorhabditis elegans is made up of three stacked unicellular tubes — an (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158261 Mon, 22 Aug 2011 23:00:00 +0100 5158261 Metabolism: Metabolic regulation by ERK http://www.medworm.com/index.php?rid=5158255&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FbalE1vQ_Zlo%2Fnrm3179 Nature Reviews Molecular Cell Biology 12, 546 (2011). doi:10.1038/nrm3179 Author: Joanna E. Huddleston A novel role for ERK signalling in the regulation of PDH flux. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158255 Mon, 22 Aug 2011 23:00:00 +0100 5158255 From the editors http://www.medworm.com/index.php?rid=5158253&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FIQe02sfWMM4%2Fnrm3182 Nature Reviews Molecular Cell Biology 12, 543 (2011). doi:10.1038/nrm3182 During development, in addition to acquiring a particular fate, cells in a tissue must complete the formidable task of acquiring the correct form. Through this process of morphogenesis, tissues and organs take their shape and position in the body. In this special Focus on Morphogenesis (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158253 Mon, 22 Aug 2011 23:00:00 +0100 5158253 Understanding morphogenetic growth control — lessons from flies http://www.medworm.com/index.php?rid=5158268&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FhaNekFwSOFc%2Fnrm3169 Authors: Ortrud Wartlick, Peer Mumcu, Frank Jülicher & Marcos Gonzalez-Gaitan Morphogens are secreted signalling molecules that control the patterning and growth of developing organs. How morphogens regulate patterning is fairly well understood; however, how they control growth is less clear. Four principal models have been proposed to explain how the morphogenetic protein Decapentaplegic (DPP) controls (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158268 Wed, 17 Aug 2011 23:00:00 +0100 5158268 Replication: Checkpoint tension relief http://www.medworm.com/index.php?rid=5158260&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FKI5hec4gB3w%2Fnrm3178 Nature Reviews Molecular Cell Biology 12, 548 (2011). doi:10.1038/nrm3178 Author: Alison Schuldt The replication checkpoint may release chromatin from the nuclear periphery. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158260 Wed, 17 Aug 2011 23:00:00 +0100 5158260 Cell death: A new platform for death http://www.medworm.com/index.php?rid=5158257&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FS-flZThJZy0%2Fnrm3174 Nature Reviews Molecular Cell Biology 12, 547 (2011). doi:10.1038/nrm3174 Author: Katharine H. Wrighton Identification of a signalling platform that can trigger apoptosis and necroptosis. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158257 Wed, 17 Aug 2011 23:00:00 +0100 5158257 Development: Staying big-brained http://www.medworm.com/index.php?rid=5158256&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FUEcNCDfaxUA%2Fnrm3177 Nature Reviews Molecular Cell Biology 12, 546 (2011). doi:10.1038/nrm3177 Author: Rachel David Brain sparing during starvation is mediated by ALK. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158256 Wed, 17 Aug 2011 23:00:00 +0100 5158256 Integrated morphodynamic signalling of the mammary gland http://www.medworm.com/index.php?rid=5158267&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FMrSuOp2sasE%2Fnrm3168 Authors: Nikolce Gjorevski & Celeste M. Nelson The mammary gland undergoes a spectacular series of changes as it develops, and maintains a remarkable capacity to remodel and regenerate for several decades. Mammary morphogenesis has been investigated for over 100 years, motivated by the dairy industry and cancer biologists. Over the past decade, (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158267 Tue, 09 Aug 2011 23:00:00 +0100 5158267 Cytoskeleton: N-WASP supports junctional integrity http://www.medworm.com/index.php?rid=5158259&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F28yhcWxGkcU%2Fnrm3172 Nature Reviews Molecular Cell Biology 12, 548 (2011). doi:10.1038/nrm3172 Author: Antony F. Bickenson Describes a non-canonical pathway for stabilization of actin at zonula adherens. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158259 Tue, 09 Aug 2011 23:00:00 +0100 5158259 Calcium: Mitochondria channel calcium http://www.medworm.com/index.php?rid=5158263&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F_Ph4XDNow3k%2Fnrm3170 Nature Reviews Molecular Cell Biology 12, 550 (2011). doi:10.1038/nrm3170 Author: Katharine H. Wrighton Nature Rev. Mol. Cell Biol. 12, 463 (2011)It has come to our attention that Baughman et al. reported similar findings in parallel to those discussed in this Research Highlight, identifying the core component of the elusive mitochondrial calcium uniporter (MCU), which (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158263 Tue, 02 Aug 2011 23:00:00 +0100 5158263 Development: The epithelial contortionists http://www.medworm.com/index.php?rid=5158254&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FKZ-GIT6J2dg%2Fnrm3171 Nature Reviews Molecular Cell Biology 12, 545 (2011). doi:10.1038/nrm3171 Author: Alison Schuldt Two groups provide insights into the subcellular events that initiate tissue morphogenesis. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158254 Tue, 02 Aug 2011 23:00:00 +0100 5158254 Protein stability: BAG6 'mops up' mislocalized proteins http://www.medworm.com/index.php?rid=5158262&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FHWZIWR3X8i0%2Fnrm3167 Nature Reviews Molecular Cell Biology 12, 550 (2011). doi:10.1038/nrm3167 Author: Rachel David BAG6 is a chaperone for mislocalized proteins. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5158262 Tue, 26 Jul 2011 23:00:00 +0100 5158262 ARF family G proteins and their regulators: roles in membrane transport, development and disease http://www.medworm.com/index.php?rid=5050074&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FcDmIaaXd3uE%2Fnrm3159 Nature Reviews Molecular Cell Biology 12, 533 (2011). doi:10.1038/nrm3159 Author: Julie G. Donaldson & Catherine L. Jackson Nature Reviews Molecular Cell Biology12, 362–375 (2011).The authors would like to note that Catherine L. Jackson's address was incomplete as it appeared in the original version of this article. This has been corrected in the online version. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050074 Thu, 21 Jul 2011 23:00:00 +0100 5050074 Molecular mechanism and physiological functions of clathrin-mediated endocytosis http://www.medworm.com/index.php?rid=5050070&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FhWwSS_9amsE%2Fnrm3151 Authors: Harvey T. McMahon & Emmanuel Boucrot Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is packaged into vesicles with the aid of a clathrin coat. It is fundamental to neurotransmission, signal transduction and the regulation of many plasma membrane activities and is thus essential to higher eukaryotic life. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050070 Thu, 21 Jul 2011 23:00:00 +0100 5050070 From unwinding to clamping — the DEAD box RNA helicase family http://www.medworm.com/index.php?rid=5050069&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FSW93ryixfJA%2Fnrm3154 Authors: Patrick Linder & Eckhard Jankowsky RNA helicases of the DEAD box family are present in all eukaryotic cells and in many bacteria and Archaea. These highly conserved enzymes are required for RNA metabolism from transcription to degradation and are therefore important players in gene expression. DEAD box proteins use ATP (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050069 Thu, 21 Jul 2011 23:00:00 +0100 5050069 The 'invisible hand': regulation of RHO GTPases by RHOGDIs http://www.medworm.com/index.php?rid=5050068&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FRSrvqIqqbgM%2Fnrm3153 Authors: Rafael Garcia-Mata, Etienne Boulter & Keith Burridge The 'invisible hand' is a term originally coined by Adam Smith in The Theory of Moral Sentiments to describe the forces of self-interest, competition and supply and demand that regulate the resources in society. This metaphor continues to be used by economists to describe (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050068 Thu, 21 Jul 2011 23:00:00 +0100 5050068 Multisubunit RNA polymerases IV and V: purveyors of non-coding RNA for plant gene silencing http://www.medworm.com/index.php?rid=5050067&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F4p5MzekWb38%2Fnrm3152 Authors: Jeremy R. Haag & Craig S. Pikaard In all eukaryotes, nuclear DNA-dependent RNA polymerases I, II and III synthesize the myriad RNAs that are essential for life. Remarkably, plants have evolved two additional multisubunit RNA polymerases, RNA polymerases IV and V, which orchestrate non-coding RNA-mediated gene silencing processes affecting development, transposon taming, (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050067 Thu, 21 Jul 2011 23:00:00 +0100 5050067 In brief http://www.medworm.com/index.php?rid=5050065&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Fb5x6ChYX3iw%2Fnrm3166 Nature Reviews Molecular Cell Biology 12, 467 (2011). doi:10.1038/nrm3166 MetabolismSmall nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stressMichel, C. I.et al. Cell Metab.14, 33–44 (2011)ArticleSmall nucleolar RNAs (snoRNAs) are non-coding RNAs with roles in ribosomal RNA (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050065 Thu, 21 Jul 2011 23:00:00 +0100 5050065 Ageing: Recapturing youth http://www.medworm.com/index.php?rid=5050064&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FnJzrr9Eo3mE%2Fnrm3160 Nature Reviews Molecular Cell Biology 12, 466 (2011). doi:10.1038/nrm3160 Author: Katharine H. Wrighton Replicative lifespan is reset during gametogenesis in budding yeast. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050064 Thu, 21 Jul 2011 23:00:00 +0100 5050064 Cell cycle: Keeping centrosome numbers in check http://www.medworm.com/index.php?rid=5050063&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FSduwqoO04o4%2Fnrm3158 Nature Reviews Molecular Cell Biology 12, 466 (2011). doi:10.1038/nrm3158 Author: Rachel David FBXW5 regulates centrosome duplication and is itself controlled by APC/C and PLK4. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050063 Thu, 21 Jul 2011 23:00:00 +0100 5050063 In brief http://www.medworm.com/index.php?rid=5050062&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FOn5U0NDXhmY%2Fnrm3165 Nature Reviews Molecular Cell Biology 12, 466 (2011). doi:10.1038/nrm3165 Organelle biogenesisA key enzyme in the biogenesis of lysosomes is a protease that regulates cholesterol metabolismMarschner, K.et al. Science333, 87–90 (2011)ArticleThe N-acetylglucosamine (GlcNAc)-1-phosphotransferase complex is required for the addition of (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050062 Thu, 21 Jul 2011 23:00:00 +0100 5050062 Cell migration: Many (converging) pathways, one destination http://www.medworm.com/index.php?rid=5050061&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FKxrk3F_53EM%2Fnrm3163 Nature Reviews Molecular Cell Biology 12, 465 (2011). doi:10.1038/nrm3163 Author: Katrin Legg SH3BP1 interacts with the exocyst to inactivate RAC1 at the leading edge. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050061 Thu, 21 Jul 2011 23:00:00 +0100 5050061 Membrane dynamics: MIEF1 mingles with mitochondria http://www.medworm.com/index.php?rid=5050060&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FzlswII60fE0%2Fnrm3161 Nature Reviews Molecular Cell Biology 12, 464 (2011). doi:10.1038/nrm3161 Author: Alison Schuldt MIEF1 is identified as a novel regulator of mitochondrial membrane dynamics. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050060 Thu, 21 Jul 2011 23:00:00 +0100 5050060 Chromatin: The inheritance of stress http://www.medworm.com/index.php?rid=5050056&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FBHvpQ1Ri6fw%2Fnrm3164 Nature Reviews Molecular Cell Biology 12, 462 (2011). doi:10.1038/nrm3164 Author: Joanna E. Huddleston Phosphorylation of ATF2 leads to heritable disruption of heterochromatin. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050056 Thu, 21 Jul 2011 23:00:00 +0100 5050056 From the editors http://www.medworm.com/index.php?rid=5050055&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FMelJXluLDN4%2Fnrm3162 Nature Reviews Molecular Cell Biology 12, 461 (2011). doi:10.1038/nrm3162 Cellular processes are controlled at many levels, from the action of regulators with global impact to the regulation of specific pathways or processes. On page 493, Burridge and colleagues use the metaphor of an 'invisible hand' to describe how the RHO-specific guanine nucleotide dissociation (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050055 Thu, 21 Jul 2011 23:00:00 +0100 5050055 Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity http://www.medworm.com/index.php?rid=5050075&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FrC8oYwar-h8%2Fnrm3150 Nature Reviews Molecular Cell Biology 12, 535 (2011). doi:10.1038/nrm3150 Author: Ana Maria Cuervo A little over 1 year ago, we lost a bright scientist and a dear colleague who, in his younger years, proposed the 'heretical' idea that lysosomes could selectively degrade cytosolic proteins. That scientist was J. Fred Dice, and his lifetime's discovery was the degradative pathway (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050075 Tue, 12 Jul 2011 23:00:00 +0100 5050075 Phosphatases: providing safe passage through mitotic exit http://www.medworm.com/index.php?rid=5050066&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FF8-rKpLu-n4%2Fnrm3149 Authors: Claudia Wurzenberger & Daniel W. Gerlich The mitosis-to-interphase transition involves dramatic cellular reorganization from a state that supports chromosome segregation to a state that complies with all functions of an interphase cell. This process, termed mitotic exit, depends on the removal of mitotic phosphorylations from a broad range of substrates. Mitotic (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050066 Tue, 12 Jul 2011 23:00:00 +0100 5050066 Ubiquitin: Timing is everything http://www.medworm.com/index.php?rid=5050059&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2Ft82eXWk_WBA%2Fnrm3157 Nature Reviews Molecular Cell Biology 12, 464 (2011). doi:10.1038/nrm3157 Author: Rachel David A chain initiation motif in APC/C substrates regulates the timing of degradation. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050059 Tue, 12 Jul 2011 23:00:00 +0100 5050059 Calcium: Mitochondria channel calcium http://www.medworm.com/index.php?rid=5050058&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FmRjnph9dORk%2Fnrm3156 Nature Reviews Molecular Cell Biology 12, 463 (2011). doi:10.1038/nrm3156 Author: Katharine H. Wrighton Identifies the long sought-after mitochondrial calcium uniporter. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050058 Tue, 12 Jul 2011 23:00:00 +0100 5050058 Cubism and the cell cycle: the many faces of the APC/C http://www.medworm.com/index.php?rid=5050073&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FarOTWjdLM0A%2Fnrm3155 Nature Reviews Molecular Cell Biology 12, 533 (2011). doi:10.1038/nrm3155 Author: Jonathon Pines Nature Reviews Molecular Cell Biology12, 427–438 (2011)On page 435 of this article, there was a mistake in the personal communication. The scientists the author received the information from are R. Wolthuis and W. van Zon. This has been corrected online. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050073 Tue, 05 Jul 2011 23:00:00 +0100 5050073 Mutually reinforcing patterning mechanisms: authors' reply http://www.medworm.com/index.php?rid=5050072&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FKAq-nNkPKAA%2Fnrm3079-c2 Authors: Adrienne H. K. Roeder, Paul T. Tarr, Cory Tobin, Xiaolan Zhang, Vijay Chickarmane, Alexandre Cunha & Elliot M. Meyerowitz With regard to our recent Opinion article (Computational morphodynamics of plants: integrating development over space and time. Nature Rev. Mol. Cell Biol.12, 265–273 (2011)), we thank Álvarez-Buylla and colleagues for their correspondence (Mutually reinforcing patterning mechanisms. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050072 Tue, 05 Jul 2011 23:00:00 +0100 5050072 Mutually reinforcing patterning mechanisms http://www.medworm.com/index.php?rid=5050071&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F1QsPMa4idNA%2Fnrm3079-c1 Authors: Elena R. Alvarez-Buylla, Mariana Benítez & Carlos Espinosa-Soto In a recent Opinion article published in Nature Reviews Molecular Cell Biology (Computational morphodynamics of plants: integrating development over space and time. Nature Rev. Mol. Cell Biol. 12, 265–273 (2011)), Roeder and collaborators integrate some of the recent work in (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050071 Tue, 05 Jul 2011 23:00:00 +0100 5050071 To Cut or NoCut in mitosis http://www.medworm.com/index.php?rid=5050057&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F5ywMztslQnQ%2Fnrm3148 Nature Reviews Molecular Cell Biology 12, 463 (2011). doi:10.1038/nrm3148 Author: Hironori Funabiki Describes the discovery of the NoCut checkpoint. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=5050057 Tue, 28 Jun 2011 23:00:00 +0100 5050057 Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process? http://www.medworm.com/index.php?rid=4959841&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FKojk7tAxhaw%2Fnrm3140 Authors: Jerome Jullien, Vincent Pasque, Richard P. Halley-Stott, Kei Miyamoto & J. B. Gurdon Differentiated cells can be experimentally reprogrammed back to pluripotency by nuclear transfer, cell fusion or induced pluripotent stem cell technology. Nuclear transfer and cell fusion can lead to efficient reprogramming of gene expression. The egg and oocyte reprogramming process includes the exchange of somatic proteins (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959841 Wed, 22 Jun 2011 23:00:00 +0100 4959841 Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death http://www.medworm.com/index.php?rid=4959840&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FmS3FTPVwD7Q%2Fnrm3143 Authors: Domagoj Vucic, Vishva M. Dixit & Ingrid E. Wertz The proper regulation of apoptosis is essential for the survival of multicellular organisms. Furthermore, excessive apoptosis can contribute to neurodegenerative diseases, anaemia and graft rejection, and diminished apoptosis can lead to autoimmune diseases and cancer. It has become clear that the post-translational modification of apoptotic (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959840 Wed, 22 Jun 2011 23:00:00 +0100 4959840 The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function http://www.medworm.com/index.php?rid=4959838&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FNVfH07U-N3w%2Fnrm3141 Authors: Danielle A. Murphy & Sara A. Courtneidge Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane of metazoan cells that represent sites of attachment to — and degradation of — the extracellular matrix. The key proteins in these structures include the actin regulators cortactin and neural Wiskott–Aldrich syndrome protein (N-WASP), (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959838 Wed, 22 Jun 2011 23:00:00 +0100 4959838 In brief http://www.medworm.com/index.php?rid=4959836&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FWygYNB6jTXA%2Fnrm3146 Nature Reviews Molecular Cell Biology 12, 405 (2011). doi:10.1038/nrm3146 ChromatinPatterns and mechanisms of ancestral histone protein inheritance in budding yeastRadman-Livaja, M.et al. PLoS Biol.9, e1001075 (2011)ArticleAlthough it is known that histone proteins broadly segregate between the two daughter strands of DNA during (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959836 Wed, 22 Jun 2011 23:00:00 +0100 4959836 Cell migration: An ABC of the RHO subfamily http://www.medworm.com/index.php?rid=4959832&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F0okoy4OuQtM%2Fnrm3144 Nature Reviews Molecular Cell Biology 12, 403 (2011). doi:10.1038/nrm3144 Author: Katrin Legg RHOA and RHOC have distinct roles in cell migration and invasion. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959832 Wed, 22 Jun 2011 23:00:00 +0100 4959832 From the editors http://www.medworm.com/index.php?rid=4959826&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FuxUa56URZhg%2Fnrm3147 Nature Reviews Molecular Cell Biology 12, 399 (2011). doi:10.1038/nrm3147 To ensure viability of itself and/or of the organism, each cell needs to accurately distribute its genomic content to its two daughter cells during cell division. This is facilitated by kinetochores — proteinaceous structures assembled on centromeric chromatin that bind spindle microtubules to mediate sister (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959826 Wed, 22 Jun 2011 23:00:00 +0100 4959826 Mechanotransduction: YAP and TAZ feel the force http://www.medworm.com/index.php?rid=4959834&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F0ZOCjuedmz8%2Fnrm3136 Nature Reviews Molecular Cell Biology 12, 404 (2011). doi:10.1038/nrm3136 Author: Katharine H. Wrighton YAP and TAZ mediate the cellular response to physical and mechanical cues. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959834 Tue, 14 Jun 2011 23:00:00 +0100 4959834 DNA replication: Pif1 overcomes a quadruplex hurdle http://www.medworm.com/index.php?rid=4959831&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FA2UnpftLbrk%2Fnrm3142 Nature Reviews Molecular Cell Biology 12, 402 (2011). doi:10.1038/nrm3142 Author: Alison Schuldt Pif1 resolves G4 structures to allow normal DNA replication in vivo. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959831 Tue, 14 Jun 2011 23:00:00 +0100 4959831 Autophagy: TFEB perfects multitasking http://www.medworm.com/index.php?rid=4959835&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F1_4g3uuaFnY%2Fnrm3139 Nature Reviews Molecular Cell Biology 12, 404 (2011). doi:10.1038/nrm3139 Author: Rachel David TFEB regulates autophagy as well as lysosomal biogenesis. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959835 Tue, 07 Jun 2011 23:00:00 +0100 4959835 Non-coding RNA: A new molecular pathway for TP53 http://www.medworm.com/index.php?rid=4959830&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F6xdW9NfQ2ww%2Fnrm3138 Nature Reviews Molecular Cell Biology 12, 402 (2011). doi:10.1038/nrm3138 Author: Mhairi Skinner A novel genetic interaction links p53 to RNA processing and homeostasis. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959830 Tue, 07 Jun 2011 23:00:00 +0100 4959830 Tinkering with nature http://www.medworm.com/index.php?rid=4959828&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F3k6xjl-nt3Y%2Fnrm3137 Nature Reviews Molecular Cell Biology 12, 400 (2011). doi:10.1038/nrm3137 Author: Peter Rehling Describes the identification and structural characterization of the Sec61 translocase. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959828 Tue, 07 Jun 2011 23:00:00 +0100 4959828 Cubism and the cell cycle: the many faces of the APC/C http://www.medworm.com/index.php?rid=4959839&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2F7zXcwsFzLsw%2Fnrm3132 Nature Reviews Molecular Cell Biology 12, 427 (2011). doi:10.1038/nrm3132 Author: Jonathon Pines One does not often look to analytic cubism for insights into the control of the cell cycle, but Pablo Picasso beautifully encapsulated the fundamentals when he said that “every act of creation is, first of all, an act of destruction”. The rapid destruction of specific (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959839 Wed, 01 Jun 2011 23:00:00 +0100 4959839 A blueprint for kinetochores — new insights into the molecular mechanics of cell division http://www.medworm.com/index.php?rid=4959837&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FmzEgh3HshCw%2Fnrm3133 Authors: Fabienne Lampert & Stefan Westermann Kinetochores are large proteinaceous complexes that physically link centromeric DNA to the plus ends of spindle microtubules. Stable kinetochore–microtubule attachments are a prerequisite for the accurate and efficient distribution of genetic material over multiple generations. In the past decade, concerted research has resulted in the (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959837 Wed, 01 Jun 2011 23:00:00 +0100 4959837 Stem cells: cNeoblasts keep their options open http://www.medworm.com/index.php?rid=4959829&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FSCK_Uz6pq54%2Fnrm3134 Nature Reviews Molecular Cell Biology 12, 401 (2011). doi:10.1038/nrm3134 Author: Rachel David A single cNeoblast can regenerate a whole flatworm. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959829 Wed, 01 Jun 2011 23:00:00 +0100 4959829 DNA repair: BRCA2 gets protective at forks http://www.medworm.com/index.php?rid=4959827&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FXPEMfSsRyW0%2Fnrm3135 Nature Reviews Molecular Cell Biology 12, 400 (2011). doi:10.1038/nrm3135 Author: Joanna E. Huddleston A novel role for BRCA2 in protecting stalled replication forks from degradation by MRE11. (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4959827 Wed, 01 Jun 2011 23:00:00 +0100 4959827 Turing's next steps: the mechanochemical basis of morphogenesis http://www.medworm.com/index.php?rid=4852656&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FTy-ibR97xiQ%2Fnrm3120 Authors: Jonathon Howard, Stephan W. Grill & Justin S. Bois Nearly 60 years ago, Alan Turing showed theoretically how two chemical species, termed morphogens, diffusing and reacting with each other can generate spatial patterns. Diffusion plays a crucial part in transporting chemical signals through space to establish the length scale of the pattern. When coupled (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4852656 Sun, 22 May 2011 23:00:00 +0100 4852656 Keeping mRNPs in check during assembly and nuclear export http://www.medworm.com/index.php?rid=4852654&cid=s_32091_171_f&fid=32091&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrm%2Frss%2Fcurrent%2F%7E3%2FepZoB0nmaPY%2Fnrm3119 Authors: Evelina Tutucci & Françoise Stutz The cell nucleus is an intricate organelle that coordinates multiple activities that are associated with DNA replication and gene expression. In all eukaryotes, it stores the genetic information and the machineries that control the production of mature and export-competent messenger ribonucleoproteins (mRNPs), a multistep process (Source: Nature Reviews Molecular Cell Biology) Nature Reviews Molecular Cell Biology journals http://www.medworm.com/rss/comments.php?id=4852654 Sun, 22 May 2011 23:00:00 +0100 4852654