MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nature Reviews Neuroscience' source. Fri, 12 Mar 2010 16:49:35 +0100 http://www.medworm.com/index.php?rid=3287496&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FFYGvI8qUv_k%2Fnrn2806 Nature Reviews Neuroscience 11, 218 (2010). doi:10.1038/nrn2806 Author: G. Rogge, D. Jones, G. W. Hubert, Y. Lin & M. J. Kuhar Nature Reviews Neuroscience9, 747–758 (2008)In figure 4a of the article, the doses of the bilateral CART (cocaine- and amphetamine-regulated transcript) peptide infusions were incorrectly given in milligrams. In both the figure and the legend, the doses should (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287496 Fri, 19 Feb 2010 16:44:04 +0100 3287496 http://www.medworm.com/index.php?rid=3287495&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FZ5LkK4YyGXY%2Fnrn2762-c2 Authors: Susanne Diekelmann & Jan Born We recently proposed a comprehensive framework for sleep-dependent memory consolidation suggesting that, during slow-wave sleep (SWS), memory representations are transferred from a temporary to a long-term store and thereby undergo reorganization in a process of system consolidation (The memory function of sleep. Nature Rev. Neurosci. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287495 Fri, 19 Feb 2010 16:44:04 +0100 3287495 http://www.medworm.com/index.php?rid=3287494&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fqb1gmNJjBgg%2Fnrn2762-c1 Authors: Matthew P. Walker & Robert Stickgold Diekelmann and Born offer an elegant and convincing overview of evidence supporting the role of sleep in the consolidation of newly acquired memories (The memory function of sleep. Nature Rev. Neurosci.11, 114–126 (2010)). An (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287494 Fri, 19 Feb 2010 16:44:04 +0100 3287494 http://www.medworm.com/index.php?rid=3287489&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FboJzgUs3pXc%2Fnrn2788 Authors: Yuko Fukata & Masaki Fukata Protein palmitoylation, a classical and common lipid modification, regulates diverse aspects of neuronal protein trafficking and function. The reversible nature of palmitoylation provides a potential general mechanism for protein shuttling between intracellular compartments. The recent discovery of palmitoylating enzymes — a large DHHC (Asp-His-His-Cys) protein (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287489 Fri, 19 Feb 2010 16:44:04 +0100 3287489 http://www.medworm.com/index.php?rid=3287487&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FwusyWE9s9J0%2Fnrn2821 Nature Reviews Neuroscience 11, 153 (2010). doi:10.1038/nrn2821 Development (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287487 Fri, 19 Feb 2010 16:44:04 +0100 3287487 http://www.medworm.com/index.php?rid=3287486&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FmEOpgZIqzyA%2Fnrn2818 Neuron–glia interactions: With a little help from glia Nature Reviews Neuroscience 11, 152 (2010). doi:10.1038/nrn2818 Author: Claudia Wiedemann D-serine release from astrocytes induces LTP in hippocampal slices. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287486 Fri, 19 Feb 2010 16:44:04 +0100 3287486 http://www.medworm.com/index.php?rid=3287484&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FmJRZrouU3YI%2Fnrn2815 Nature Reviews Neuroscience 11, 152 (2010). doi:10.1038/nrn2815 Author: Katherine Whalley High-throughput screens have been developed to assess the effects of drugs on behaviour in zebrafish. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287484 Fri, 19 Feb 2010 16:44:04 +0100 3287484 http://www.medworm.com/index.php?rid=3287483&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FFOCLR_aSmEg%2Fnrn2816 Nature Reviews Neuroscience 11, 151 (2010). doi:10.1038/nrn2816 Author: Cristian Bodo A population of neurons in the somatosensory cortex responds specifically to the direction of a moving tactile stimulus. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287483 Fri, 19 Feb 2010 16:44:04 +0100 3287483 http://www.medworm.com/index.php?rid=3287481&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FkaHkogcg5L0%2Fnrn2820 Nature Reviews Neuroscience 11, 150 (2010). doi:10.1038/nrn2820 Neuronal plasticity (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287481 Fri, 19 Feb 2010 16:44:04 +0100 3287481 http://www.medworm.com/index.php?rid=3287480&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FGZJn3izoMmM%2Fnrn2814 Nature Reviews Neuroscience 11, 150 (2010). doi:10.1038/nrn2814 Author: Monica Hoyos Flight DAPK1 is a specific cell death signal that is recruited to NMDA receptors and mediates brain damage in stroke. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287480 Fri, 19 Feb 2010 16:44:04 +0100 3287480 http://www.medworm.com/index.php?rid=3287479&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F-fmR6G_tluU%2Fnrn2817 Nature Reviews Neuroscience 11, 149 (2010). doi:10.1038/nrn2817 Author: Katherine Whalley Correlated firing in cortical circuits may be weaker than was previously thought. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287479 Fri, 19 Feb 2010 16:44:04 +0100 3287479 http://www.medworm.com/index.php?rid=3287478&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FSIGhq5W_iew%2Fnrn2819 Nature Reviews Neuroscience 11, 147 (2010). doi:10.1038/nrn2819 This issue of Nature Reviews Neuroscience contains several articles about aspects of the transmission of information and disease in the nervous system.In his Review on page 188, Benjamin Kaupp compares and contrasts the chemosensory receptors and signalling mechanisms involved in olfaction in (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287478 Fri, 19 Feb 2010 16:44:04 +0100 3287478 http://www.medworm.com/index.php?rid=3287492&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FonBEVG_1TOg%2Fnrn2793 Authors: Ian J. Deary, Lars Penke & Wendy Johnson Neuroscience is contributing to an understanding of the biological bases of human intelligence differences. This work is principally being conducted along two empirical fronts: genetics — quantitative and molecular — and brain imaging. Quantitative genetic studies have established that there are additive genetic contributions to (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287492 Wed, 10 Feb 2010 00:00:00 +0100 3287492 http://www.medworm.com/index.php?rid=3287491&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FrHTB2rFoly8%2Fnrn2789 Nature Reviews Neuroscience 11, 188 (2010). doi:10.1038/nrn2789 Author: U. Benjamin Kaupp Vertebrates and insects have evolved complex repertoires of chemosensory receptors to detect and distinguish odours. With a few exceptions, vertebrate chemosensory receptors belong to the family of G protein-coupled receptors that initiate a cascade of cellular signalling events and thereby electrically excite the neuron. Insect (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287491 Wed, 10 Feb 2010 00:00:00 +0100 3287491 http://www.medworm.com/index.php?rid=3287485&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FWC2pWSfbVj8%2Fnrn2813 Nature Reviews Neuroscience 11, 152 (2010). doi:10.1038/nrn2813 Author: Cristian Bodo Coadministration of α2-adrenoceptor antagonists accelerates the effects of antidepressants. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287485 Wed, 10 Feb 2010 00:00:00 +0100 3287485 http://www.medworm.com/index.php?rid=3287482&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F1Ufiduv9EEU%2Fnrn2812 Nature Reviews Neuroscience 11, 151 (2010). doi:10.1038/nrn2812 Author: Leonie Welberg Neuronal expression of PrPC is required for the maintenance of the myelin sheaths around peripheral nerves. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287482 Wed, 10 Feb 2010 00:00:00 +0100 3287482 http://www.medworm.com/index.php?rid=3287490&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FdvUgZXsSAZM%2Fnrn2761 Authors: Luciano Conti & Elena Cattaneo Neural stem cells (NSCs) can be experimentally derived or induced from different sources, and the NSC systems generated so far are promising tools for basic research and biomedical applications. However, no direct and thorough comparison of their biological and molecular properties or of their physiological (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287490 Thu, 28 Jan 2010 00:00:00 +0100 3287490 http://www.medworm.com/index.php?rid=3188991&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FydkUIX6ip3U%2Fnrn2757 Authors: Christian Giaume, Annette Koulakoff, Lisa Roux, David Holcman & Nathalie Rouach Dynamic aspects of interactions between astrocytes, neurons and the vasculature have recently been in the neuroscience spotlight. It has emerged that not only neurons but also astrocytes are organized into networks. Whereas neuronal networks exchange information through electrical and chemical synapses, astrocytes are interconnected through (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188991 Wed, 20 Jan 2010 17:07:12 +0100 3188991 http://www.medworm.com/index.php?rid=3188990&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F7BnKQd9td0s%2Fnrn2802 Nature Reviews Neuroscience 11, 71 (2010). doi:10.1038/nrn2802 The importance of coordinating activity across neural networks for brain function. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188990 Wed, 20 Jan 2010 17:07:12 +0100 3188990 http://www.medworm.com/index.php?rid=3188989&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F3H9XshtG7Nc%2Fnrn2801 Nature Reviews Neuroscience 11, 75 (2010). doi:10.1038/nrn2801 Visual system (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188989 Wed, 20 Jan 2010 17:07:12 +0100 3188989 http://www.medworm.com/index.php?rid=3188988&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FvZy1GDXYmGM%2Fnrn2800 Nature Reviews Neuroscience 11, 76 (2010). doi:10.1038/nrn2800 Sensory systems (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188988 Wed, 20 Jan 2010 17:07:12 +0100 3188988 http://www.medworm.com/index.php?rid=3188987&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FZmwKoinJeyo%2Fnrn2799 Nature Reviews Neuroscience 11, 74 (2010). doi:10.1038/nrn2799 Author: Claudia Wiedemann GABAergic interneurons were identified as hub cells that trigger network synchronization in the hippocampus. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188987 Wed, 20 Jan 2010 17:07:12 +0100 3188987 http://www.medworm.com/index.php?rid=3188986&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F_0dWquTgsBU%2Fnrn2798 Nature Reviews Neuroscience 11, 72 (2010). doi:10.1038/nrn2798 Author: Katherine Whalley LRRTM2 drives presynaptic and postsynaptic synapse assembly and is a ligand for neurexin 1 (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188986 Wed, 20 Jan 2010 17:07:12 +0100 3188986 http://www.medworm.com/index.php?rid=3188985&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FxMyULN286lI%2Fnrn2796 Nature Reviews Neuroscience 11, 74 (2010). doi:10.1038/nrn2796 Author: Leonie Welberg Inflammation-induced nuclear export of HDAC1 disrupts axonal transport of mitochondria, initiating axonal damage in models of demyelinating diseases. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188985 Wed, 20 Jan 2010 17:07:12 +0100 3188985 http://www.medworm.com/index.php?rid=3188984&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FXDDAUpKefhc%2Fnrn2774 Authors: Peter J. Uhlhaas & Wolf Singer Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188984 Wed, 20 Jan 2010 17:07:12 +0100 3188984 http://www.medworm.com/index.php?rid=3188983&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FzdpK4uIVgG4%2Fnrn2792 Nature Reviews Neuroscience 11, 73 (2010). doi:10.1038/nrn2792 Author: Monica Hoyos Flight The switch from attraction to repulsion downstream of cAMP depends on a switch from EPAC- to PKA-mediated signalling. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188983 Wed, 13 Jan 2010 00:00:00 +0100 3188983 http://www.medworm.com/index.php?rid=3188982&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FnH0nm0IivRs%2Fnrn2794 Nature Reviews Neuroscience 11, 74 (2010). doi:10.1038/nrn2794 Author: Leonie Welberg MicroRNA 206 promotes muscle reinnervation in a mouse model of amyotrophic lateral sclerosis (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188982 Wed, 13 Jan 2010 00:00:00 +0100 3188982 http://www.medworm.com/index.php?rid=3188981&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FVqdLq0DcTl0%2Fnrn2787 Nature Reviews Neuroscience 11, 127 (2010). doi:10.1038/nrn2787 Author: Karl Friston A free-energy principle has been proposed recently that accounts for action, perception and learning. This Review looks at some key brain theories in the biological (for example, neural Darwinism) and physical (for example, information theory and optimal control theory) sciences from the free-energy perspective. Crucially, (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188981 Wed, 13 Jan 2010 00:00:00 +0100 3188981 http://www.medworm.com/index.php?rid=3188980&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fre9vWPDf1hA%2Fnrn2776 Centenary of Brodmann's map — conception and fate Nature Reviews Neuroscience 11, 139 (2010). doi:10.1038/nrn2776 Authors: Karl Zilles & Katrin Amunts Rarely in the history of neuroscience has a single illustration been as influential as the cytoarchitectonic map of the human brain published by Korbinian Brodmann in his monograph from 1909. The map presents the segregation of the cerebral cortex into 43 areas, as visible in (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188980 Mon, 04 Jan 2010 00:00:00 +0100 3188980 http://www.medworm.com/index.php?rid=3188979&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fq-lEGBARlG0%2Fnrn2791 Nature Reviews Neuroscience 11, 76 (2010). doi:10.1038/nrn2791 Author: Leonie Welberg Fear memories can be blocked in humans by updating them during a window of reconsolidation with new, non-fear-related information. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188979 Mon, 04 Jan 2010 00:00:00 +0100 3188979 http://www.medworm.com/index.php?rid=3188978&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fpy-MXimZgG0%2Fnrn2790 Nature Reviews Neuroscience 11, 73 (2010). doi:10.1038/nrn2790 Author: Katherine Whalley Future activity in individual neurons can be predicted from past activity of small ensembles. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188978 Mon, 04 Jan 2010 00:00:00 +0100 3188978 http://www.medworm.com/index.php?rid=3188977&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FgTyeAkRQpgQ%2Fnrn2762 Authors: Susanne Diekelmann & Jan Born Sleep has been identified as a state that optimizes the consolidation of newly acquired information in memory, depending on the specific conditions of learning and the timing of sleep. Consolidation during sleep promotes both quantitative and qualitative changes of memory representations. Through specific patterns of (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188977 Mon, 04 Jan 2010 00:00:00 +0100 3188977 http://www.medworm.com/index.php?rid=3287493&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FAwnwEHrYdHQ%2Fnrn2740 Nature Reviews Neuroscience 11, 212 (2010). doi:10.1038/nrn2740 Author: Shai Shaham Neuronal synapses are important microstructures that underlie complex cognitive capacities. Recent studies, primarily in Caenorhabditis elegans and Drosophila melanogaster, have revealed surprising parallels between these synapses and the 'chemosensory synapses' that reside at the tips of chemosensory cells that respond to environmental stimuli. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287493 Wed, 23 Dec 2009 00:00:00 +0100 3287493 http://www.medworm.com/index.php?rid=3287488&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FEhAps3e1HaE%2Fnrn2786 Authors: Bess Frost & Marc I. Diamond Many non-infectious neurodegenerative diseases are associated with the accumulation of fibrillar proteins. These diseases all exhibit features that are reminiscent of those of prionopathies, including phenotypic diversity and the propagation of pathology. Furthermore, emerging studies of amyloid-β, α-synuclein and tau — proteins implicated in common (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3287488 Wed, 23 Dec 2009 00:00:00 +0100 3287488 http://www.medworm.com/index.php?rid=3100525&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FCBspXa11huw%2Fnrn2785 Nature Reviews Neuroscience 11, 1 (2010). doi:10.1038/nrn2785 Adaptive changes in neural circuits and in the communication of science. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100525 Fri, 18 Dec 2009 16:21:14 +0100 3100525 http://www.medworm.com/index.php?rid=3100524&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FAjZa9cMattk%2Fnrn2784 Nature Reviews Neuroscience 11, 3 (2010). doi:10.1038/nrn2784 Author: Claudia Wiedemann Cannabidiol attenuates cue-induced drug-seeking behaviour in heroin-addicted rats. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100524 Fri, 18 Dec 2009 16:21:14 +0100 3100524 http://www.medworm.com/index.php?rid=3100523&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FbBdUz5k6mss%2Fnrn2783 Nature Reviews Neuroscience 11, 6 (2010). doi:10.1038/nrn2783 Synapse formation (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100523 Fri, 18 Dec 2009 16:21:14 +0100 3100523 http://www.medworm.com/index.php?rid=3100522&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F14Bzm4dpjRc%2Fnrn2782 Nature Reviews Neuroscience 11, 6 (2010). doi:10.1038/nrn2782 Author: Katherine Whalley Enhanced tonic inhibition causes seizures in several animal models of epilepsy. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100522 Fri, 18 Dec 2009 16:21:14 +0100 3100522 http://www.medworm.com/index.php?rid=3100521&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Flerct-jxCrM%2Fnrn2781 Nature Reviews Neuroscience 11, 7 (2010). doi:10.1038/nrn2781 Chemosensation (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100521 Fri, 18 Dec 2009 16:21:14 +0100 3100521 http://www.medworm.com/index.php?rid=3100520&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FZ4hr-w_epas%2Fnrn2780 Nature Reviews Neuroscience 11, 4 (2010). doi:10.1038/nrn2780 Author: Iley Ozerlat Cadherin-2 drives the directional migration of granule cells during cerebellar development. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100520 Fri, 18 Dec 2009 16:21:14 +0100 3100520 http://www.medworm.com/index.php?rid=3100519&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FTkhBJXvYNAA%2Fnrn2754 Authors: Elena Jazin & Larry Cahill A plethora of discoveries relating to sex influences on brain function is rapidly moving this field into the spotlight for most areas of neuroscience. The domain of molecular or genetic neuroscience is no exception. The goal of this article is to highlight key developments concerning (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100519 Fri, 18 Dec 2009 16:21:14 +0100 3100519 http://www.medworm.com/index.php?rid=3188976&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FEOqU5l3KDY4%2Fnrn2755 Authors: Nibaldo C. Inestrosa & Ernest Arenas The roles of the Wnt signalling pathway in several developmental processes, including synaptic differentiation, are well characterized. The expression of Wnt ligands and Wnt signalling components in the mature mammalian CNS suggests that this pathway might also play a part in synaptic maintenance and function. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3188976 Wed, 16 Dec 2009 00:00:00 +0100 3188976 http://www.medworm.com/index.php?rid=3100514&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fl22PqYYgYBQ%2Fnrn2756 Authors: Paul Dean, John Porrill, Carl-Fredrik Ekerot & Henrik Jörntell Initial investigations of the cerebellar microcircuit inspired the Marr–Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding of cerebellar microcircuit characteristics and in the computational analysis of Marr–Albus models. We conclude that many Marr–Albus models are in effect adaptive filters, (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100514 Wed, 09 Dec 2009 00:00:00 +0100 3100514 http://www.medworm.com/index.php?rid=3100513&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FZmwKoinJeyo%2Fnrn2799 Nature Reviews Neuroscience 11, 5 (2010). doi:10.1038/nrn2799 Author: Leonie Welberg Vesicle recycling has an important role in maintaining circadian clock gene expression in the SCN. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100513 Wed, 09 Dec 2009 00:00:00 +0100 3100513 http://www.medworm.com/index.php?rid=3100512&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FBuupCoXgBSs%2Fnrn2778 Nature Reviews Neuroscience 11, 6 (2010). doi:10.1038/nrn2778 Author: Leonie Welberg In the tadpole visual system LTP and LTD can spread to the upstream synapse. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100512 Wed, 09 Dec 2009 00:00:00 +0100 3100512 http://www.medworm.com/index.php?rid=3100511&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FXLbZWJHVB-U%2Fnrn2777 Nature Reviews Neuroscience 11, 4 (2010). doi:10.1038/nrn2777 Author: Claudia Wiedemann Amyloid–β and tau synergistically impair mitochondrial function in AD mice. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100511 Wed, 09 Dec 2009 00:00:00 +0100 3100511 http://www.medworm.com/index.php?rid=3100518&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F__ZnGa9dOB8%2Fnrn2775 Nature Reviews Neuroscience 11, 5 (2010). doi:10.1038/nrn2775 Author: Katherine Whalley FOXP2 variants differentially regulate brain gene expression, providing clues to language evolution. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100518 Wed, 02 Dec 2009 00:00:00 +0100 3100518 http://www.medworm.com/index.php?rid=3100517&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fhty8-2HU4uA%2Fnrn2737 Authors: Yuka Sasaki, Jose E. Nanez & Takeo Watanabe Visual perceptual learning (VPL) is defined as a long-term improvement in performance on a visual task. In recent years, the idea that conscious effort is necessary for VPL to occur has been challenged by research suggesting the involvement of more implicit processing mechanisms, such as (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100517 Wed, 02 Dec 2009 00:00:00 +0100 3100517 http://www.medworm.com/index.php?rid=3100516&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F0vC5VruOUOg%2Fnrn2773 Authors: Judy Illes, Mary Anne Moser, Jennifer B. McCormick, Eric Racine, Sandra Blakeslee, Arthur Caplan, Erika Check Hayden, Jay Ingram, Tiffany Lohwater, Peter McKnight, Christie Nicholson, Anthony Phillips, Kevin D. Sauvé, Elaine Snell & Samuel Weiss There is increasing pressure for neuroscientists to communicate their research and the societal implications of their findings to the public. Communicating science is challenging, and the transformation of communication by digital and interactive media increases the complexity of the challenge. To facilitate dialogue with the (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100516 Wed, 02 Dec 2009 00:00:00 +0100 3100516 http://www.medworm.com/index.php?rid=3100515&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FRYpmtRadKlw%2Fnrn2759 Authors: Aaron G. Blankenship & Marla B. Feller Patterned, spontaneous activity occurs in many developing neural circuits, including the retina, the cochlea, the spinal cord, the cerebellum and the hippocampus, where it provides signals that are important for the development of neurons and their connections. Despite there being differences in adult architecture and (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100515 Wed, 02 Dec 2009 00:00:00 +0100 3100515 http://www.medworm.com/index.php?rid=3100510&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FHL0YmTWPgnU%2Fnrn2758 Authors: Lotfi B. Merabet & Alvaro Pascual-Leone There is growing evidence that sensory deprivation is associated with crossmodal neuroplastic changes in the brain. After visual or auditory deprivation, brain areas that are normally associated with the lost sense are recruited by spared sensory modalities. These changes underlie adaptive and compensatory behaviours in (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3100510 Wed, 25 Nov 2009 00:00:00 +0100 3100510 http://www.medworm.com/index.php?rid=3012176&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F6minUfx7Epc%2Fnrn2772 Nature Reviews Neuroscience 10, 831 (2009). doi:10.1038/nrn2772 The fortieth annual Society for Neuroscience meeting this year welcomed over 30,000 delegates and was again a resounding success, with talks and posters pointing to important developments and approaches in neuroscience, several of which will feature in forthcoming issues of Nature Reviews Neuroscience.MicroRNAs (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012176 Fri, 20 Nov 2009 16:26:26 +0100 3012176 http://www.medworm.com/index.php?rid=3012175&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F6EocD6edpA4%2Fnrn2771 Nature Reviews Neuroscience 10, 835 (2009). doi:10.1038/nrn2771 Place cells (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012175 Fri, 20 Nov 2009 16:26:26 +0100 3012175 http://www.medworm.com/index.php?rid=3012174&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F3POQQbGHDXQ%2Fnrn2770 Nature Reviews Neuroscience 10, 834 (2009). doi:10.1038/nrn2770 Pain (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012174 Fri, 20 Nov 2009 16:26:26 +0100 3012174 http://www.medworm.com/index.php?rid=3012173&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FuMpxREjm5Ac%2Fnrn2769 Nature Reviews Neuroscience 10, 833 (2009). doi:10.1038/nrn2769 Author: Claudia Wiedemann The molecular mechanisms that regulate synapse formation are not well understood. Eroglu et al. show that thrombospondin (TSP) binding to the neuronal α2δ-1 receptor initiates the formation of new synapses in vitro and in vivo and that the anti-epileptic and analgesic drug (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012173 Fri, 20 Nov 2009 16:26:26 +0100 3012173 http://www.medworm.com/index.php?rid=3012172&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F0wubFdhEq8k%2Fnrn2768 Nature Reviews Neuroscience 10, 836 (2009). doi:10.1038/nrn2768 Author: Leonie Welberg Early-life stress (ELS) has long-lasting effects on the brain, and the epigenetic mechanisms underlying them are beginning to be unravelled. Murgatroyd et al. now show that methyl-CpG-binding protein 2 (MeCP2)-mediated regulation of arginine vasopressin (Avp) gene expression in parvocellular hypothalamus (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012172 Fri, 20 Nov 2009 16:26:26 +0100 3012172 http://www.medworm.com/index.php?rid=3012171&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FBG9ppPSdgq8%2Fnrn2767 Neurogenesis: A mother–daughter relationship Nature Reviews Neuroscience 10, 833 (2009). doi:10.1038/nrn2767 Author: Katherine Whalley Radial glia in the ventricular zone (VZ) of the developing cortex divide asymmetrically, producing a self-renewing radial glial cell that remains in the VZ and a cell that differentiates into a neuron or an intermediate progenitor. How these differing fates are determined was unknown; however, (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012171 Fri, 20 Nov 2009 16:26:26 +0100 3012171 http://www.medworm.com/index.php?rid=3012170&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fk3riHkuvtw0%2Fnrn2766 Nature Reviews Neuroscience 10, 834 (2009). doi:10.1038/nrn2766 Author: Monica Hoyos Flight In sensory processing, a neuron's firing rate and the timing of the spikes relative to the stimulus onset together encode information. In reality, however, stimuli are often ongoing, raising the question of what else could provide a reference point for spike timing. Previous studies suggested (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012170 Fri, 20 Nov 2009 16:26:26 +0100 3012170 http://www.medworm.com/index.php?rid=3012169&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F7OSMx5DBYM0%2Fnrn2738 Nature Reviews Neuroscience 10, 850 (2009). doi:10.1038/nrn2738 Author: Liliana Minichiello Understanding the mechanisms that underlie learning is one of the most fascinating and central aims of neurobiological research. Hippocampal long-term potentiation (LTP) is widely regarded as a prime candidate for the cellular mechanism of learning. The receptor tyrosine kinase TrkB (also known as NTRK2), known (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012169 Fri, 20 Nov 2009 16:26:26 +0100 3012169 http://www.medworm.com/index.php?rid=3012166&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fgbj82rr8_Ng%2Fnrn2765 Nature Reviews Neuroscience 10, 834 (2009). doi:10.1038/nrn2765 Author: Lucy Bird A study involving real-time imaging of effector T cells provides new insight into how autoreactive T cells interact with cerebral structures and access the central nervous system (CNS) to cause autoimmune disease.Flügel and colleagues induced experimental autoimmune encephalomyelitis in rats with intravenous injection of (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012166 Wed, 11 Nov 2009 00:00:00 +0100 3012166 http://www.medworm.com/index.php?rid=3012165&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F6gv8_cnwxUs%2Fnrn2764 Nature Reviews Neuroscience 10, 832 (2009). doi:10.1038/nrn2764 Author: Leonie Welberg Flies rely on their sense of smell to navigate their environment. Mushroom body neurons have a key role in olfactory memory, but little is known about the circuits that provide these cells with relevant information. Two studies now identify distinct dopaminergic projections to specific mushroom (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012165 Wed, 11 Nov 2009 00:00:00 +0100 3012165 http://www.medworm.com/index.php?rid=3012164&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FXXaWqc-KsiU%2Fnrn2760 Nature Reviews Neuroscience 10, 836 (2009). doi:10.1038/nrn2760 Author: Katherine Whalley Cleavage of the amyloid precursor protein (APP) at the cell surface produces extracellular amyloid-β peptides (Aβ) and the APP intracellular domain, AICD. The predominant hypotheses in the Alzheimer's disease (AD) field have traditionally focused on a causative role for Aβ; however, a new (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012164 Wed, 11 Nov 2009 00:00:00 +0100 3012164 http://www.medworm.com/index.php?rid=3012163&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FY4OgsFcKFwI%2Fnrn2741 Authors: Brian A. Wandell & Stelios M. Smirnakis It is important to understand the balance between cortical plasticity and stability in various systems and across spatial scales in the adult brain. Here we review studies of adult plasticity in primary visual cortex (V1), which has a key role in distributing visual information. There (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012163 Wed, 11 Nov 2009 00:00:00 +0100 3012163 http://www.medworm.com/index.php?rid=3012162&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FCvsCI8Erf5E%2Fnrn2726 Authors: Stephen M. Eacker, Ted M. Dawson & Valina L. Dawson Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012162 Wed, 11 Nov 2009 00:00:00 +0100 3012162 http://www.medworm.com/index.php?rid=3012161&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FYDbabVkoaTA%2Fnrn2753 Authors: Geoffrey Schoenbaum, Matthew R. Roesch, Thomas A. Stalnaker & Yuji K. Takahashi The orbitofrontal cortex (OFC) is crucial for changing established behaviour in the face of unexpected outcomes. This function has been attributed to the role of the OFC in response inhibition or to the idea that the OFC is a rapidly flexible associative-learning area. However, recent (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012161 Wed, 11 Nov 2009 00:00:00 +0100 3012161 http://www.medworm.com/index.php?rid=3012168&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FExLfEvMhZ_Y%2Fnrn2735 Authors: Timothy H. Murphy & Dale Corbett Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which results in damage to neuronal networks and the impairment of sensation, movement or cognition. Evidence from animal models suggests that a time-limited window of neuroplasticity opens following a stroke, (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012168 Wed, 04 Nov 2009 00:00:00 +0100 3012168 http://www.medworm.com/index.php?rid=3012167&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FgDcLmszWQNE%2Fnrn2763 Nature Reviews Neuroscience 10, 842 (2009). doi:10.1038/nrn2763 Author: Gerhard Schratt MicroRNAs (miRNAs) are emerging as key modulators of post-transcriptional gene regulation in a plethora of tissues, including the nervous system. Recent evidence points to a widespread role for neural miRNAs at various stages of synaptic development, including dendritogenesis, synapse formation and synapse maturation. Furthermore, studies (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=3012167 Wed, 04 Nov 2009 00:00:00 +0100 3012167 http://www.medworm.com/index.php?rid=2908435&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FZlnWp64KLyY%2Fnrn2752 Nature Reviews Neuroscience 10, 767 (2009). doi:10.1038/nrn2752 Oscillations (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908435 Tue, 20 Oct 2009 15:39:51 +0100 2908435 http://www.medworm.com/index.php?rid=2908434&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F-KtmJWbvopA%2Fnrn2751 Nature Reviews Neuroscience 10, 764 (2009). doi:10.1038/nrn2751 Neurodegenerative disease (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908434 Tue, 20 Oct 2009 15:39:51 +0100 2908434 http://www.medworm.com/index.php?rid=2908433&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F7b_fqexevw0%2Fnrn2750 Nature Reviews Neuroscience 10, 761 (2009). doi:10.1038/nrn2750 As this month's issue goes to press we eagerly anticipate this year's Society for Neuroscience meeting in Chicago, which as always promises to bring together scientists from all fields of neuroscience. The meeting often leads to an interest in topics that might not be directly (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908433 Tue, 20 Oct 2009 15:39:51 +0100 2908433 http://www.medworm.com/index.php?rid=2908432&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F2xpdJnySVBM%2Fnrn2749 Nature Reviews Neuroscience 10, 765 (2009). doi:10.1038/nrn2749 Author: Charlotte Harrison A recent paper in the Journal of Neuroscience has shown that inhibitors of histone deacetylases (HDACs) — enzymes that affect the acetylation status of histones and regulate the remodelling of chromatin — have antidepressant actions.Although currently used antidepressants rapidly modulate monoaminergic systems in (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908432 Tue, 20 Oct 2009 15:39:51 +0100 2908432 http://www.medworm.com/index.php?rid=2908431&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FhyG9B6e5kBA%2Fnrn2748 Nature Reviews Neuroscience 10, 829 (2009). doi:10.1038/nrn2748 Author: Tomás J. Ryan & Seth G. N. Grant Nature Reviews Neuroscience10, 701–712 (2009)On page 708 of the above article, the word 'deuterostomes' was incorrectly used instead of 'protostomes'. The sentence should have read: “Protostomes have single NR2 and Dlg genes whereas chordates have four (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908431 Tue, 20 Oct 2009 15:39:51 +0100 2908431 http://www.medworm.com/index.php?rid=2908430&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FDRYQ8vbUnJ8%2Fnrn2747 Nature Reviews Neuroscience 10, 766 (2009). doi:10.1038/nrn2747 Author: Claudia Wiedemann Once dendrites have established coverage of their receptive fields during development, growth of the dendritic arbour in synchrony with body growth (dendritic scaling) is essential to maintain the coverage. How this proportional growth of dendrites is coordinated is largely unknown. A study by Jan and (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908430 Tue, 20 Oct 2009 15:39:51 +0100 2908430 http://www.medworm.com/index.php?rid=2908429&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FvtaYyPnO5rA%2Fnrn2746 Nature Reviews Neuroscience 10, 763 (2009). doi:10.1038/nrn2746 Author: Katherine Whalley Mutations in disrupted in schizophrenia 1 (DISC1) are a risk factor for multiple psychiatric and mental disorders, and DISC1 regulates diverse aspects of neuronal physiology. However, the molecular mechanisms by which DISC1 mediates its effects are largely unknown. Enomoto et al. and (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908429 Tue, 20 Oct 2009 15:39:51 +0100 2908429 http://www.medworm.com/index.php?rid=2908428&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F_yyAVdsRl00%2Fnrn2745 Nature Reviews Neuroscience 10, 766 (2009). doi:10.1038/nrn2745 Author: Katherine Whalley That astrocytes are more than merely supportive elements of the nervous system is no longer news: in recent years they have been linked to multiple processes, including the regulation of synapse formation and neuronal activity. Filosa et al. now show that neuron–astrocyte interactions that (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908428 Tue, 20 Oct 2009 15:39:51 +0100 2908428 http://www.medworm.com/index.php?rid=2908427&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F4kCF7WQBz_w%2Fnrn2736 Authors: Giovanni Frazzetto & Suzanne Anker Neuroscience addresses questions that, if resolved, will reveal aspects of our individuality. Therefore neuroscientific knowledge is not solely constrained within laboratories, but readily captures the attention of the public at large. Ideas, concepts and images in neuroscience widely circulate in culture and are portrayed in (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908427 Tue, 20 Oct 2009 15:39:51 +0100 2908427 http://www.medworm.com/index.php?rid=2908426&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FX664ozGDgPY%2Fnrn2667-c1 Authors: Parashkev Nachev, Christopher Kennard & Masud Husain In their illuminating recent article (Is the rostro-caudal axis of the frontal lobe hierarchical? Nature Rev. Neurosci.10, 659–669 (2009)), Badre and D'Esposito generalize to the frontal lobes as a whole a point we recently made about (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908426 Tue, 13 Oct 2009 23:00:00 +0100 2908426 http://www.medworm.com/index.php?rid=2908425&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F27zm_-fzJbQ%2Fnrn2734 Authors: Stefano L. Sensi, Pierre Paoletti, Ashley I. Bush & Israel Sekler The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology. The recent development of powerful tools, including zinc-sensitive fluorescent probes, selective chelators and genetically modified animal models, has brought a deeper understanding of the roles of this cation as a crucial (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908425 Tue, 13 Oct 2009 23:00:00 +0100 2908425 http://www.medworm.com/index.php?rid=2908424&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F3YSnx9uYaVI%2Fnrn2744 Nature Reviews Neuroscience 10, 765 (2009). doi:10.1038/nrn2744 Author: Claudia Wiedemann Rett syndrome is a neurodevelopmental disorder that manifests in early childhood and is caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2). Previous studies have shown that synaptic input to layer 5 pyramidal neurons is abnormal in Mecp2-null mice, (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908424 Tue, 13 Oct 2009 23:00:00 +0100 2908424 http://www.medworm.com/index.php?rid=2908423&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FY-3tJZT3nfY%2Fnrn2743 Nature Reviews Neuroscience 10, 766 (2009). doi:10.1038/nrn2743 Author: Leonie Welberg The resting brain is not idle but shows continuous, spontaneous fluctuations in activity, which correlate between functionally related brain regions. Previous studies indicated that spontaneous, resting-state functional connectivity remains stable during development, sleep and anaesthesia, but Corbetta and colleagues now show that it can change (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908423 Tue, 13 Oct 2009 23:00:00 +0100 2908423 http://www.medworm.com/index.php?rid=2908422&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FGJmChAKc5cM%2Fnrn2722 Authors: Allan R. Jones, Caroline C. Overly & Susan M. Sunkin The Allen Brain Atlas, a Web-based, genome-wide atlas of gene expression in the adult mouse brain, was an experiment on a massive scale. The development of the atlas faced a combination of great technical challenges and a non-traditional open research model, and it encountered many (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908422 Tue, 13 Oct 2009 23:00:00 +0100 2908422 http://www.medworm.com/index.php?rid=2908421&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fyin6yKN2LK8%2Fnrn2742 Nature Reviews Neuroscience 10, 764 (2009). doi:10.1038/nrn2742 Author: Leonie Welberg Aggregation of extracellular amyloid-β (Aβ) is thought to play a major part in the pathogenesis of Alzheimer's disease. Amyloid plaques form when levels of the monomeric, soluble Aβ peptide build up in the interstitial fluid (ISF) in the brain. Holtzman and colleagues now show that (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908421 Tue, 13 Oct 2009 23:00:00 +0100 2908421 http://www.medworm.com/index.php?rid=2908420&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FeiEnN7PYOfQ%2Fnrn2733 Authors: Seralynne D. Vann, John P. Aggleton & Eleanor A. Maguire The past decade has seen a transformation in research on the retrosplenial cortex (RSC). This cortical area has emerged as a key member of a core network of brain regions that underpins a range of cognitive functions, including episodic memory, navigation, imagination and planning for (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908420 Wed, 07 Oct 2009 23:00:00 +0100 2908420 http://www.medworm.com/index.php?rid=2908419&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F36k5viZicbs%2Fnrn2716 Nature Reviews Neuroscience 10, 803 (2009). doi:10.1038/nrn2716 Author: J. Allan Hobson Dreaming has fascinated and mystified humankind for ages: the bizarre and evanescent qualities of dreams have invited boundless speculation about their origin, meaning and purpose. For most of the twentieth century, scientific dream theories were mainly psychological. Since the discovery of rapid eye movement (REM) (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908419 Wed, 30 Sep 2009 23:00:00 +0100 2908419 http://www.medworm.com/index.php?rid=2828015&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FBrkkxF2TLLE%2Fnrn2732 Nature Reviews Neuroscience 10, 693 (2009). doi:10.1038/nrn2732 Our special focus issue this month celebrates the contribution of Darwin's ideas to our understanding of the evolution of the nervous system, featuring articles that discuss the molecular, cellular and structural changes that have contributed to CNS evolution and the functional consequences of these changes. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828015 Thu, 24 Sep 2009 18:11:59 +0100 2828015 http://www.medworm.com/index.php?rid=2828014&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FdKcZVbewQRQ%2Fnrn2731 Nature Reviews Neuroscience 10, 697 (2009). doi:10.1038/nrn2731 Synaptic plasticity (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828014 Thu, 24 Sep 2009 18:11:59 +0100 2828014 http://www.medworm.com/index.php?rid=2828013&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FgthgL_OCRvk%2Fnrn2730 Nature Reviews Neuroscience 10, 694 (2009). doi:10.1038/nrn2730 Author: Katherine Whalley Some prion diseases have been associated with familial mutations in the gene encoding the prion protein (PrP). However, how these mutations contribute to the disease process was not well understood. Lindquist and colleagues now show for the first time that mutations in PrP can produce (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828013 Thu, 24 Sep 2009 18:11:59 +0100 2828013 http://www.medworm.com/index.php?rid=2828012&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F2rCJvp4wOcM%2Fnrn2729 Nature Reviews Neuroscience 10, 698 (2009). doi:10.1038/nrn2729 Author: Claudia Wiedemann The regulation of fear memory extinction differs between juvenile and adult mice; however, the molecular basis of this difference is not known. Herry and colleagues now show that the formation of perineuronal nets (PNNs) in the amygdala prevents the permanent extinction of fear memories in (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828012 Thu, 24 Sep 2009 18:11:59 +0100 2828012 http://www.medworm.com/index.php?rid=2828011&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FTHqKRJeeUZI%2Fnrn2728 Nature Reviews Neuroscience 10, 696 (2009). doi:10.1038/nrn2728 Author: Claudia Wiedemann Circadian rhythms such as the locomotor activity rhythm are regulated by changes in gene transcription; however, little is known about the role of post-transcriptional mechanisms. Kadener et al. identify candidate microRNAs (miRNAs) that influence circadian rhythmicity and show that in Drosophila melanogaster the (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828011 Thu, 24 Sep 2009 18:11:59 +0100 2828011 http://www.medworm.com/index.php?rid=2828010&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FWRm6gYIiK-E%2Fnrn2727 Nature Reviews Neuroscience 10, 696 (2009). doi:10.1038/nrn2727 Social neuroscience (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828010 Thu, 24 Sep 2009 18:11:59 +0100 2828010 http://www.medworm.com/index.php?rid=2828009&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F7Sd0qADEg4o%2Fnrn2719 This article describes how novelties that make us (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828009 Thu, 24 Sep 2009 18:11:59 +0100 2828009 http://www.medworm.com/index.php?rid=2828008&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FX5Zq7pISIQU%2Fnrn2718 Nature Reviews Neuroscience 10, 698 (2009). doi:10.1038/nrn2718 Author: Katherine Whalley During neuromuscular junction (NMJ) development, target muscle cells become innervated by the axonal arbor of one motor neuron. As the muscle grows, the arbor size increases and new synapses are added. Fuentes-Medel et al. have now examined this process in the Drosophila melanogaster (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828008 Thu, 24 Sep 2009 18:11:59 +0100 2828008 http://www.medworm.com/index.php?rid=2828007&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FMf5OYMWdq1Q%2Fnrn2707 Authors: Elly M. Tanaka & Patrizia Ferretti For many years the mammalian CNS has been seen as an organ that is unable to regenerate. However, it was also long known that lower vertebrate species are capable of impressive regeneration of CNS structures. How did this situation arise through evolution? Increasing cellular and (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828007 Thu, 24 Sep 2009 18:11:59 +0100 2828007 http://www.medworm.com/index.php?rid=2908418&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fqx_CYEp-IqI%2Fnrn2720 Nature Reviews Neuroscience 10, 769 (2009). doi:10.1038/nrn2720 Author: Christian Klämbt Neurons and glial cells show mutual interdependence in many developmental and functional aspects of their biology. To establish their intricate relationships with neurons, glial cells must migrate over what are often long distances. In the CNS glial cells generally migrate as single cells, whereas PNS (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2908418 Tue, 22 Sep 2009 23:00:00 +0100 2908418 http://www.medworm.com/index.php?rid=2819813&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FU53c0hkP3i4%2Fnrn2715 Nature Reviews Neuroscience 10, 625 (2009). doi:10.1038/nrn2715 Neuroimmunology (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819813 Tue, 22 Sep 2009 18:16:56 +0100 2819813 http://www.medworm.com/index.php?rid=2819812&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FA-zG_l9mpE4%2Fnrn2714 Nature Reviews Neuroscience 10, 622 (2009). doi:10.1038/nrn2714 Ion channelsv (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819812 Tue, 22 Sep 2009 18:16:56 +0100 2819812 http://www.medworm.com/index.php?rid=2819811&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FZm5GfNsZQcg%2Fnrn2712 Nature Reviews Neuroscience 10, 619 (2009). doi:10.1038/nrn2712 Repairing damage to the nervous system that occurs as a result of trauma or disease remains one of the key goals of neuroscience research. Several of the strategies under investigation are highlighted in this month's issue. Approaches that are being considered to protect and repair (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819811 Tue, 22 Sep 2009 18:16:56 +0100 2819811 http://www.medworm.com/index.php?rid=2819810&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FsefKghtYcvc%2Fnrn2711 Nature Reviews Neuroscience 10, 624 (2009). doi:10.1038/nrn2711 Author: Katherine Whalley How do the topographic maps that are characteristic of sensory brain regions form during development? Sakano and colleagues show that interactions between neuropilin 1 (NRP1) and its ligand semaphorin 3A (SEMA3A) regulate the organization of olfactory sensory neuron (OSN) axons long before they reach their (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819810 Tue, 22 Sep 2009 18:16:56 +0100 2819810 http://www.medworm.com/index.php?rid=2819809&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fq7MwN68r8pU%2Fnrn2710 Nature Reviews Neuroscience 10, 621 (2009). doi:10.1038/nrn2710 Author: Claudia Wiedemann The success of current approaches to promote recovery of motor function after spinal cord injury (SCI) is often very limited. Three studies using rodents now describe several potential new treatment strategies for SCI.The role of infiltrating macrophages and resident microglia in the recovery from (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819809 Tue, 22 Sep 2009 18:16:56 +0100 2819809 http://www.medworm.com/index.php?rid=2819808&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FW528SEb2v0w%2Fnrn2709 Nature Reviews Neuroscience 10, 623 (2009). doi:10.1038/nrn2709 Author: Monica Hoyos Flight Despite evidence of an involvement of inflammatory and immunological mechanisms in the pathogenesis of Alzheimer's disease, the therapeutic benefits of anti-inflammatory agents are still unclear. A study published in the Journal of Immunology shows for the first time that inhibition of the receptor for (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819808 Tue, 22 Sep 2009 18:16:56 +0100 2819808 http://www.medworm.com/index.php?rid=2819807&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FuCeQSbIF1Wo%2Fnrn2708 Nature Reviews Neuroscience 10, 624 (2009). doi:10.1038/nrn2708 Author: Leonie Welberg Dopamine has a well-established role in learning and decision making related to rewarding stimuli that are important for survival, such as food, water and sex. Two papers now extend dopamine's functional repertoire to include roles in processing abstract rewards and in perceptual decision making.Bromberg-Martin (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819807 Tue, 22 Sep 2009 18:16:56 +0100 2819807 http://www.medworm.com/index.php?rid=2819806&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FuV6evrTgGXw%2Fnrn2701 Authors: Alex Bayés & Seth G. N. Grant Advances in technology have equipped the field of neuroproteomics with refined tools for the study of the expression, interaction and function of proteins in the nervous system. In combination with bioinformatics, neuroproteomics can address the organization of dynamic, functional protein networks and macromolecular structures that (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819806 Tue, 22 Sep 2009 18:16:56 +0100 2819806 http://www.medworm.com/index.php?rid=2819805&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FQPPo7Gt1UwA%2Fnrn2699 Authors: Anthony Holtmaat & Karel Svoboda Synaptic plasticity in adult neural circuits may involve the strengthening or weakening of existing synapses as well as structural plasticity, including synapse formation and elimination. Indeed, long-term in vivo imaging studies are beginning to reveal the structural dynamics of neocortical neurons in the normal (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819805 Tue, 22 Sep 2009 18:16:56 +0100 2819805 http://www.medworm.com/index.php?rid=2819804&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F5O-hG82qtHU%2Fnrn2698 Authors: Richard Apps & Richard Hawkes The fundamental architecture of the cerebellum is concealed within a terminological forest — transverse zones and stripes, longitudinal zones and microzones, patches, etc. To make things worse, the same term is used in different contexts to describe quite different patterns of spatial localization. Here we (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819804 Tue, 22 Sep 2009 18:16:56 +0100 2819804 http://www.medworm.com/index.php?rid=2819803&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FJHqSllpthYA%2Fnrn2681 Authors: Ceren Korkut & Vivian Budnik Although WNTs have been long thought of as regulators of cell fate, recent studies highlight their involvement in crucial aspects of synaptic development in the nervous system. Particularly compelling are recent studies of the neuromuscular junction in nematodes, insects, fish and mammals. These studies place (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819803 Tue, 22 Sep 2009 18:16:56 +0100 2819803 http://www.medworm.com/index.php?rid=2807418&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2732 Nature Reviews Neuroscience 10, 693 (2009). doi:10.1038/nrn2732 Our special focus issue this month celebrates the contribution of Darwin's ideas to our understanding of the evolution of the nervous system, featuring articles that discuss the molecular, cellular and structural changes that have contributed to CNS evolution and the functional consequences of these changes. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807418 Fri, 18 Sep 2009 18:03:00 +0100 2807418 http://www.medworm.com/index.php?rid=2807417&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2731 Nature Reviews Neuroscience 10, 697 (2009). doi:10.1038/nrn2731 Synaptic plasticity (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807417 Fri, 18 Sep 2009 18:03:00 +0100 2807417 http://www.medworm.com/index.php?rid=2807416&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2730 Nature Reviews Neuroscience 10, 694 (2009). doi:10.1038/nrn2730 Author: Katherine Whalley Some prion diseases have been associated with familial mutations in the gene encoding the prion protein (PrP). However, how these mutations contribute to the disease process was not well understood. Lindquist and colleagues now show for the first time that mutations in PrP can produce (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807416 Fri, 18 Sep 2009 18:03:00 +0100 2807416 http://www.medworm.com/index.php?rid=2807415&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2729 Nature Reviews Neuroscience 10, 698 (2009). doi:10.1038/nrn2729 Author: Claudia Wiedemann The regulation of fear memory extinction differs between juvenile and adult mice; however, the molecular basis of this difference is not known. Herry and colleagues now show that the formation of perineuronal nets (PNNs) in the amygdala prevents the permanent extinction of fear memories in (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807415 Fri, 18 Sep 2009 18:03:00 +0100 2807415 http://www.medworm.com/index.php?rid=2807414&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2728 Nature Reviews Neuroscience 10, 696 (2009). doi:10.1038/nrn2728 Author: Claudia Wiedemann Circadian rhythms such as the locomotor activity rhythm are regulated by changes in gene transcription; however, little is known about the role of post-transcriptional mechanisms. Kadener et al. identify candidate microRNAs (miRNAs) that influence circadian rhythmicity and show that in Drosophila melanogaster the (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807414 Fri, 18 Sep 2009 18:03:00 +0100 2807414 http://www.medworm.com/index.php?rid=2807413&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2727 Nature Reviews Neuroscience 10, 696 (2009). doi:10.1038/nrn2727 Social neuroscience (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807413 Fri, 18 Sep 2009 18:03:00 +0100 2807413 http://www.medworm.com/index.php?rid=2807412&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2719 This article describes how novelties that make us (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807412 Fri, 18 Sep 2009 18:03:00 +0100 2807412 http://www.medworm.com/index.php?rid=2807411&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2718 Nature Reviews Neuroscience 10, 698 (2009). doi:10.1038/nrn2718 Author: Katherine Whalley During neuromuscular junction (NMJ) development, target muscle cells become innervated by the axonal arbor of one motor neuron. As the muscle grows, the arbor size increases and new synapses are added. Fuentes-Medel et al. have now examined this process in the Drosophila melanogaster (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807411 Fri, 18 Sep 2009 18:03:00 +0100 2807411 http://www.medworm.com/index.php?rid=2807410&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2707 Authors: Elly M. Tanaka & Patrizia Ferretti For many years the mammalian CNS has been seen as an organ that is unable to regenerate. However, it was also long known that lower vertebrate species are capable of impressive regeneration of CNS structures. How did this situation arise through evolution? Increasing cellular and (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807410 Fri, 18 Sep 2009 18:03:00 +0100 2807410 http://www.medworm.com/index.php?rid=2828005&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F5ePbJpKTfvs%2Fnrn2713 MicroRNAs tell an evo–devo story Nature Reviews Neuroscience 10, 754 (2009). doi:10.1038/nrn2713 Author: Kenneth S. Kosik Evolutionary developmental biology, often called evo–devo, seeks to understand the ancestral relationship among organisms by comparing their developmental strategies and ultimately reconstructing the pathways that led to the extraordinary variety of biological forms. The insights from this synthesis of developmental biology and evolutionary principles are (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828005 Tue, 08 Sep 2009 23:00:00 +0100 2828005 http://www.medworm.com/index.php?rid=2828004&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fn2wSx5mxEA0%2Fnrn2703 Nature Reviews Neuroscience 10, 736 (2009). doi:10.1038/nrn2703 Author: Linda Z. Holland The vertebrate brain is highly complex with millions to billions of neurons. During development, the neural plate border region gives rise to the neural crest, cranial placodes and, in anamniotes, to Rohon-Beard sensory neurons, whereas the boundary region of the midbrain and hindbrain develops organizer (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828004 Tue, 08 Sep 2009 23:00:00 +0100 2828004 http://www.medworm.com/index.php?rid=2828003&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FmS7Vch8dOWg%2Fnrn2725 Nature Reviews Neuroscience 10, 696 (2009). doi:10.1038/nrn2725 Author: Leonie Welberg An animal's behaviour is influenced by many factors in its external and internal environment, most of which interact with its genome, making accurate prediction of how it will behave in a given situation difficult. Luksys et al. now show that several of these factors (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828003 Tue, 08 Sep 2009 23:00:00 +0100 2828003 http://www.medworm.com/index.php?rid=2828002&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fm1SDMA2cWN0%2Fnrn2724 Neuron–glia interactions: Glia make waves Nature Reviews Neuroscience 10, 695 (2009). doi:10.1038/nrn2724 Author: Leonie Welberg The 'slow waves' in slow-wave sleep represent cortical activity that is synchronized at a low frequency. Several mechanisms probably control these slow oscillations, and Fellin et al. now show that 'gliotransmitters' released by astrocytes play an important part in this process.The authors used (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828002 Tue, 08 Sep 2009 23:00:00 +0100 2828002 http://www.medworm.com/index.php?rid=2828001&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FcJ0PBkHLYv0%2Fnrn2723 Nature Reviews Neuroscience 10, 695 (2009). doi:10.1038/nrn2723 Author: Katherine Whalley Many aspects of primate social interactions rely on the ability to distinguish between the faces of different individuals. Two recent studies now provide insights into the neural mechanisms of face perception in non-human primates.Previous work had identified a group of neurons in the macaque (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828001 Tue, 08 Sep 2009 23:00:00 +0100 2828001 http://www.medworm.com/index.php?rid=2828000&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F0iVvL8FcMso%2Fnrn2717 Authors: Tomás J. Ryan & Seth G. N. Grant Understanding the evolutionary origins of behaviour is a central aim in the study of biology and may lead to insights into human disorders. Synaptic transmission is observed in a wide range of invertebrate and vertebrate organisms and underlies their behaviour. Proteomic studies of the molecular (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828000 Tue, 08 Sep 2009 23:00:00 +0100 2828000 http://www.medworm.com/index.php?rid=2807408&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2713 MicroRNAs tell an evo–devo story Nature Reviews Neuroscience 10, 754 (2009). doi:10.1038/nrn2713 Author: Kenneth S. Kosik Evolutionary developmental biology, often called evo–devo, seeks to understand the ancestral relationship among organisms by comparing their developmental strategies and ultimately reconstructing the pathways that led to the extraordinary variety of biological forms. The insights from this synthesis of developmental biology and evolutionary principles are (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807408 Tue, 08 Sep 2009 23:00:00 +0100 2807408 http://www.medworm.com/index.php?rid=2807407&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2703 Nature Reviews Neuroscience 10, 736 (2009). doi:10.1038/nrn2703 Author: Linda Z. Holland The vertebrate brain is highly complex with millions to billions of neurons. During development, the neural plate border region gives rise to the neural crest, cranial placodes and, in anamniotes, to Rohon-Beard sensory neurons, whereas the boundary region of the midbrain and hindbrain develops organizer (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807407 Tue, 08 Sep 2009 23:00:00 +0100 2807407 http://www.medworm.com/index.php?rid=2807406&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2725 Nature Reviews Neuroscience 10, 696 (2009). doi:10.1038/nrn2725 Author: Leonie Welberg An animal's behaviour is influenced by many factors in its external and internal environment, most of which interact with its genome, making accurate prediction of how it will behave in a given situation difficult. Luksys et al. now show that several of these factors (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807406 Tue, 08 Sep 2009 23:00:00 +0100 2807406 http://www.medworm.com/index.php?rid=2807405&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2724 Neuron–glia interactions: Glia make waves Nature Reviews Neuroscience 10, 695 (2009). doi:10.1038/nrn2724 Author: Leonie Welberg The 'slow waves' in slow-wave sleep represent cortical activity that is synchronized at a low frequency. Several mechanisms probably control these slow oscillations, and Fellin et al. now show that 'gliotransmitters' released by astrocytes play an important part in this process.The authors used (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807405 Tue, 08 Sep 2009 23:00:00 +0100 2807405 http://www.medworm.com/index.php?rid=2807404&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2723 Nature Reviews Neuroscience 10, 695 (2009). doi:10.1038/nrn2723 Author: Katherine Whalley Many aspects of primate social interactions rely on the ability to distinguish between the faces of different individuals. Two recent studies now provide insights into the neural mechanisms of face perception in non-human primates.Previous work had identified a group of neurons in the macaque (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807404 Tue, 08 Sep 2009 23:00:00 +0100 2807404 http://www.medworm.com/index.php?rid=2807403&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2717 Authors: Tomás J. Ryan & Seth G. N. Grant Understanding the evolutionary origins of behaviour is a central aim in the study of biology and may lead to insights into human disorders. Synaptic transmission is observed in a wide range of invertebrate and vertebrate organisms and underlies their behaviour. Proteomic studies of the molecular (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807403 Tue, 08 Sep 2009 23:00:00 +0100 2807403 http://www.medworm.com/index.php?rid=2827999&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FUuAwhz6KMS4%2Fnrn2721 Nature Reviews Neuroscience 10, 759 (2009). doi:10.1038/nrn2721 Author: Anthony Holtmaat & Karel Svoboda Nature Reviews Neuroscience10, 647–658 (2009)On page 654 of the above article, the scale bar in parts a and f of figure 4 should represent 5 μm rather than 5 mm. This has been corrected in the (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2827999 Thu, 20 Aug 2009 23:00:00 +0100 2827999 http://www.medworm.com/index.php?rid=2807402&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2721 Nature Reviews Neuroscience 10, 759 (2009). doi:10.1038/nrn2721 Author: Anthony Holtmaat & Karel Svoboda Nature Reviews Neuroscience10, 647–658 (2009)On page 654 of the above article, the scale bar in parts a and f of figure 4 should represent 5 μm rather than 5 mm. This has been corrected in the (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807402 Thu, 20 Aug 2009 23:00:00 +0100 2807402 http://www.medworm.com/index.php?rid=2715789&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2715 Nature Reviews Neuroscience 10, 625 (2009). doi:10.1038/nrn2715 Neuroimmunology (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715789 Thu, 20 Aug 2009 11:54:49 +0100 2715789 http://www.medworm.com/index.php?rid=2715788&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2714 Nature Reviews Neuroscience 10, 622 (2009). doi:10.1038/nrn2714 Ion channelsv (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715788 Thu, 20 Aug 2009 11:54:49 +0100 2715788 http://www.medworm.com/index.php?rid=2715787&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2712 Nature Reviews Neuroscience 10, 619 (2009). doi:10.1038/nrn2712 Repairing damage to the nervous system that occurs as a result of trauma or disease remains one of the key goals of neuroscience research. Several of the strategies under investigation are highlighted in this month's issue. Approaches that are being considered to protect and repair (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715787 Thu, 20 Aug 2009 11:54:49 +0100 2715787 http://www.medworm.com/index.php?rid=2715786&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2711 Nature Reviews Neuroscience 10, 624 (2009). doi:10.1038/nrn2711 Author: Katherine Whalley How do the topographic maps that are characteristic of sensory brain regions form during development? Sakano and colleagues show that interactions between neuropilin 1 (NRP1) and its ligand semaphorin 3A (SEMA3A) regulate the organization of olfactory sensory neuron (OSN) axons long before they reach their (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715786 Thu, 20 Aug 2009 11:54:49 +0100 2715786 http://www.medworm.com/index.php?rid=2715785&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2710 Nature Reviews Neuroscience 10, 621 (2009). doi:10.1038/nrn2710 Author: Claudia Wiedemann The success of current approaches to promote recovery of motor function after spinal cord injury (SCI) is often very limited. Three studies using rodents now describe several potential new treatment strategies for SCI.The role of infiltrating macrophages and resident microglia in the recovery from (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715785 Thu, 20 Aug 2009 11:54:49 +0100 2715785 http://www.medworm.com/index.php?rid=2715784&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2709 Nature Reviews Neuroscience 10, 623 (2009). doi:10.1038/nrn2709 Author: Monica Hoyos Flight Despite evidence of an involvement of inflammatory and immunological mechanisms in the pathogenesis of Alzheimer's disease, the therapeutic benefits of anti-inflammatory agents are still unclear. A study published in the Journal of Immunology shows for the first time that inhibition of the receptor for (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715784 Thu, 20 Aug 2009 11:54:49 +0100 2715784 http://www.medworm.com/index.php?rid=2715783&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2708 Nature Reviews Neuroscience 10, 624 (2009). doi:10.1038/nrn2708 Author: Leonie Welberg Dopamine has a well-established role in learning and decision making related to rewarding stimuli that are important for survival, such as food, water and sex. Two papers now extend dopamine's functional repertoire to include roles in processing abstract rewards and in perceptual decision making.Bromberg-Martin (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715783 Thu, 20 Aug 2009 11:54:49 +0100 2715783 http://www.medworm.com/index.php?rid=2715782&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2701 Authors: Alex Bayés & Seth G. N. Grant Advances in technology have equipped the field of neuroproteomics with refined tools for the study of the expression, interaction and function of proteins in the nervous system. In combination with bioinformatics, neuroproteomics can address the organization of dynamic, functional protein networks and macromolecular structures that (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715782 Thu, 20 Aug 2009 11:54:49 +0100 2715782 http://www.medworm.com/index.php?rid=2715781&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2699 Authors: Anthony Holtmaat & Karel Svoboda Synaptic plasticity in adult neural circuits may involve the strengthening or weakening of existing synapses as well as structural plasticity, including synapse formation and elimination. Indeed, long-term in vivo imaging studies are beginning to reveal the structural dynamics of neocortical neurons in the normal (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715781 Thu, 20 Aug 2009 11:54:49 +0100 2715781 http://www.medworm.com/index.php?rid=2715780&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2698 Authors: Richard Apps & Richard Hawkes The fundamental architecture of the cerebellum is concealed within a terminological forest — transverse zones and stripes, longitudinal zones and microzones, patches, etc. To make things worse, the same term is used in different contexts to describe quite different patterns of spatial localization. Here we (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715780 Thu, 20 Aug 2009 11:54:49 +0100 2715780 http://www.medworm.com/index.php?rid=2715779&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2681 Authors: Ceren Korkut & Vivian Budnik Although WNTs have been long thought of as regulators of cell fate, recent studies highlight their involvement in crucial aspects of synaptic development in the nervous system. Particularly compelling are recent studies of the neuromuscular junction in nematodes, insects, fish and mammals. These studies place (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715779 Thu, 20 Aug 2009 11:54:49 +0100 2715779 http://www.medworm.com/index.php?rid=2819802&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FBg4XKbid-j0%2Fnrn2706 Nature Reviews Neuroscience 10, 622 (2009). doi:10.1038/nrn2706 Author: Claudia Wiedemann Activation of GABAARs (γ-aminobutyric acid type A receptors) leads to the elevation of intracellular Ca2+ concentration ([Ca2+]i in immature neurons, through a well-established signalling pathway that is important for neuronal migration. NG2 cells — a group of (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819802 Tue, 11 Aug 2009 23:00:00 +0100 2819802 http://www.medworm.com/index.php?rid=2819801&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FfVIkDjcytMw%2Fnrn2705 Nature Reviews Neuroscience 10, 624 (2009). doi:10.1038/nrn2705 Author: Katherine Whalley On the back of promising animal studies, several trials of neural transplantation for the treatment of neurodegenerative diseases have been initiated over the past decade. Last year the first long-term evaluations of fetal dopaminergic neuron transplantation in patients with Parkinson's disease produced mixed results: (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819801 Tue, 11 Aug 2009 23:00:00 +0100 2819801 http://www.medworm.com/index.php?rid=2819800&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FUOgAt2Is8QU%2Fnrn2667 Authors: David Badre & Mark D'Esposito The frontal lobes in the brain are a component of the cerebral system that supports goal-directed behaviour. However, their functional organization remains controversial. Recent studies have reported rostro-caudal distinctions in frontal cortex activity based on the abstractness of action representations. In addition, some have proposed (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819800 Tue, 11 Aug 2009 23:00:00 +0100 2819800 http://www.medworm.com/index.php?rid=2715778&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2706 Nature Reviews Neuroscience 10, 622 (2009). doi:10.1038/nrn2706 Author: Claudia Wiedemann Activation of GABAARs (γ-aminobutyric acid type A receptors) leads to the elevation of intracellular Ca2+ concentration ([Ca2+]i in immature neurons, through a well-established signalling pathway that is important for neuronal migration. NG2 cells — a group of (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715778 Tue, 11 Aug 2009 23:00:00 +0100 2715778 http://www.medworm.com/index.php?rid=2715777&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2705 Nature Reviews Neuroscience 10, 624 (2009). doi:10.1038/nrn2705 Author: Katherine Whalley On the back of promising animal studies, several trials of neural transplantation for the treatment of neurodegenerative diseases have been initiated over the past decade. Last year the first long-term evaluations of fetal dopaminergic neuron transplantation in patients with Parkinson's disease produced mixed results: (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715777 Tue, 11 Aug 2009 23:00:00 +0100 2715777 http://www.medworm.com/index.php?rid=2715776&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2667 Authors: David Badre & Mark D'Esposito The frontal lobes in the brain are a component of the cerebral system that supports goal-directed behaviour. However, their functional organization remains controversial. Recent studies have reported rostro-caudal distinctions in frontal cortex activity based on the abstractness of action representations. In addition, some have proposed (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715776 Tue, 11 Aug 2009 23:00:00 +0100 2715776 http://www.medworm.com/index.php?rid=2828006&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FtvSWC7Y9Bzw%2Fnrn2697 Nature Reviews Neuroscience 10, 747 (2009). doi:10.1038/nrn2697 Author: Jerome M. Siegel Sleep is often viewed as a vulnerable state that is incompatible with behaviours that nourish and propagate species. This has led to the hypothesis that sleep has survived because it fulfills some universal, but as yet unknown, vital function. I propose that sleep is best (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2828006 Tue, 04 Aug 2009 23:00:00 +0100 2828006 http://www.medworm.com/index.php?rid=2819799&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F6L2cMDW7CRA%2Fnrn2704 Nature Reviews Neuroscience 10, 622 (2009). doi:10.1038/nrn2704 Author: Leonie Welberg Adult neurogenesis takes place in only a few brain areas, including the dentate gyrus, but its functional relevance is still unclear. Here, Gage and colleagues studied the role of adult-born dentate gyrus neurons in pattern separation, a process that creates distinct neural representations for similar (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819799 Tue, 04 Aug 2009 23:00:00 +0100 2819799 http://www.medworm.com/index.php?rid=2819798&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FBIPPrWsT8zw%2Fnrn2685 Authors: Gorka Orive, Eduardo Anitua, José Luis Pedraz & Dwaine F. Emerich Biomaterials are likely to have an increasingly important role in the treatment of nervous system disorders. Recently developed biomaterials can enable and augment the targeted delivery of drugs or therapeutic proteins to the brain, allow cell or tissue transplants to be effectively delivered to the (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2819798 Tue, 04 Aug 2009 23:00:00 +0100 2819798 http://www.medworm.com/index.php?rid=2807409&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2697 Nature Reviews Neuroscience 10, 747 (2009). doi:10.1038/nrn2697 Author: Jerome M. Siegel Sleep is often viewed as a vulnerable state that is incompatible with behaviours that nourish and propagate species. This has led to the hypothesis that sleep has survived because it fulfills some universal, but as yet unknown, vital function. I propose that sleep is best (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2807409 Tue, 04 Aug 2009 23:00:00 +0100 2807409 http://www.medworm.com/index.php?rid=2715775&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnrn2704 Nature Reviews Neuroscience 10, 622 (2009). doi:10.1038/nrn2704 Author: Leonie Welberg Adult neurogenesis takes place in only a few brain areas, including the dentate gyrus, but its functional relevance is still unclear. Here, Gage and colleagues studied the role of adult-born dentate gyrus neurons in pattern separation, a process that creates distinct neural representations for similar (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=2715775 Tue, 04 Aug 2009 23:00:00 +0100 2715775