Nature Reviews Neuroscience via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nature Reviews Neuroscience' source. Tue, 07 Feb 2012 07:05:46 +0100 Interneuron dysfunction in psychiatric disorders http://www.medworm.com/index.php?rid=5618156&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FpMBxbVC6S2o%2Fnrn3155 Nature Reviews Neuroscience 13, 107 (2012). doi:10.1038/nrn3155 Author: Oscar Marín Schizophrenia, autism and intellectual disabilities are best understood as spectrums of diseases that have broad sets of causes. However, it is becoming evident that these conditions also have overlapping phenotypes and genetics, which is suggestive of common deficits. In this context, the idea that the (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618156 Wed, 18 Jan 2012 05:00:00 +0100 5618156 Activity-dependent neurotransmitter respecification http://www.medworm.com/index.php?rid=5618155&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FWrVzFm0jZ5s%2Fnrn3154 Nature Reviews Neuroscience 13, 94 (2012). doi:10.1038/nrn3154 Author: Nicholas C. Spitzer For many years it has been assumed that the identity of the transmitters expressed by neurons is stable and unchanging. Recent work, however, shows that electrical activity can respecify neurotransmitter expression during development and in the mature nervous system, and an understanding is emerging of (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618155 Wed, 18 Jan 2012 05:00:00 +0100 5618155 Neuronal circuits: Mapping the local field potential http://www.medworm.com/index.php?rid=5618153&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FQK3thNeAHdc%2Fnrn3180 Nature Reviews Neuroscience 13, 75 (2012). doi:10.1038/nrn3180 Author: Sian Lewis The local field potential (LFP) is the low-frequency component of the extracellular voltage detected in the cortex, and changes in the LFP have been linked to many important processes, such as memory and motor function. Several recent reports have suggested that the LFP arises from (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618153 Wed, 18 Jan 2012 05:00:00 +0100 5618153 Ion channels: Optogenetics gets selective! http://www.medworm.com/index.php?rid=5618152&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Ftjt3axE0kVw%2Fnrn3179 Nature Reviews Neuroscience 13, 75 (2012). doi:10.1038/nrn3179 Author: Sian Lewis Optogenetic targeting of specific cell populations in rats has not been possible until now. A new study demonstrates a method for creating genetically restricted, recombinase-driven rat lines in which opsins can be expressed in specific populations of neurons. Witten et al. generated tyrosine hydroxylase–Cre (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618152 Wed, 18 Jan 2012 05:00:00 +0100 5618152 Brain evolution: MicroRNAs: big influence in brain evolution http://www.medworm.com/index.php?rid=5618151&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F0KKMKUySdCo%2Fnrn3178 Nature Reviews Neuroscience 13, 75 (2012). doi:10.1038/nrn3178 Author: Sian Lewis It has been suggested that the rapid evolution of brain gene expression might partly account for the emergence of human cognition. Using microarrays and computational analysis, Somel et al. found that the rate of divergence of developmentally expressed genes in humans was 3–5 times (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618151 Wed, 18 Jan 2012 05:00:00 +0100 5618151 Neural development: Clustering connections http://www.medworm.com/index.php?rid=5618150&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2ForKfZ8DS2z0%2Fnrn3187 Nature Reviews Neuroscience 13, 74 (2012). doi:10.1038/nrn3187 Author: Darran Yates Repetitive spontaneous activity in developing neural networks causes spatiotemporal clustering of functional synapses on dendrites. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618150 Wed, 18 Jan 2012 05:00:00 +0100 5618150 Psychiatric disorders: Why two is better than one http://www.medworm.com/index.php?rid=5618147&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FmTTJ1VDKnTE%2Fnrn3181 Nature Reviews Neuroscience 13, 73 (2012). doi:10.1038/nrn3181 Author: Leonie Welberg The antidepressant fluoxetine increases synaptic plasticity in the amygdala and thereby facilitates fear erasure through extinction. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618147 Wed, 18 Jan 2012 05:00:00 +0100 5618147 Neural development: Emergence of patterned activity in the motor system http://www.medworm.com/index.php?rid=5618145&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F5CowtwDucX4%2Fnrn3186 Nature Reviews Neuroscience 13, 72 (2012). doi:10.1038/nrn3186 Author: Katherine Whalley Spontaneous activity bursts contribute to network formation in many parts of the developing nervous system. Warp et al. used time-lapse imaging and optical manipulation of activity to investigate the emergence of spontaneous patterned activity in the developing zebrafish motor system. They found that the (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618145 Wed, 18 Jan 2012 05:00:00 +0100 5618145 Social neuroscience: Oxytocin boosts social awareness http://www.medworm.com/index.php?rid=5618144&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F5kfrMsJJo2M%2Fnrn3185 Nature Reviews Neuroscience 13, 72 (2012). doi:10.1038/nrn3185 Author: Katherine Whalley Sensitivity to the experiences of others contributes to many social behaviours including empathy and cooperation. Here, the authors show that oxytocin influences social behaviour in rhesus macaques in a context-dependent manner. When the monkeys had to choose whether to deliver a reward to another monkey (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618144 Wed, 18 Jan 2012 05:00:00 +0100 5618144 Learning and memory: Becoming a habit: a role for NMDA receptors http://www.medworm.com/index.php?rid=5618143&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FCT2zRdoesKw%2Fnrn3184 Nature Reviews Neuroscience 13, 72 (2012). doi:10.1038/nrn3184 Author: Katherine Whalley The actions of dopamine in the basal ganglia are important for the transformation of a repeated action into an automated habit; however, the precise mechanisms by which dopamine is modulated during habit learning are unclear. Here, the authors show that mice in which NMDAR1 is (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618143 Wed, 18 Jan 2012 05:00:00 +0100 5618143 Neural development: Epigenetic regulation of asymmetry http://www.medworm.com/index.php?rid=5618142&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FXDyaCDPuXuo%2Fnrn3183 Nature Reviews Neuroscience 13, 72 (2012). doi:10.1038/nrn3183 Author: Katherine Whalley The brains of many species demonstrate structural and functional bilateral asymmetry, yet the underlying molecular mechanisms are mostly unknown. In the Caenorhabditis elegans nervous system, the lineages arising from the two daughter cells of a particular blastomere known as ABarap produce a different cell (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618142 Wed, 18 Jan 2012 05:00:00 +0100 5618142 Neurodegenerative disease: Preventing 'SIRTain' death by mutant huntingtin http://www.medworm.com/index.php?rid=5618140&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FrIEduN4-u40%2Fnrn3182 Nature Reviews Neuroscience 13, 71 (2012). doi:10.1038/nrn3182 Author: Monica Hoyos Flight Two independent studies link mutant huntingtin to inactivation of the deacetylase enzyme SIRT1 and highlight a neuroprotective role for SIRT1 in mouse models of Huntington's disease. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618140 Wed, 18 Jan 2012 05:00:00 +0100 5618140 Spectral fingerprints of large-scale neuronal interactions http://www.medworm.com/index.php?rid=5618157&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FvUlmHox0PZQ%2Fnrn3137 Authors: Markus Siegel, Tobias H. Donner & Andreas K. Engel Cognition results from interactions among functionally specialized but widely distributed brain regions; however, neuroscience has so far largely focused on characterizing the function of individual brain regions and neurons therein. Here we discuss recent studies that have instead investigated the interactions between brain regions during (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618157 Wed, 11 Jan 2012 05:00:00 +0100 5618157 Neuroimmunology: Interferon-γ tunes the rhythm http://www.medworm.com/index.php?rid=5618149&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FKlb9JM4zS14%2Fnrn3177 Nature Reviews Neuroscience 13, 74 (2012). doi:10.1038/nrn3177 Author: Leonie Welberg Two immune-related molecules regulate network rhythmicity by controlling GABA transmission. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618149 Wed, 11 Jan 2012 05:00:00 +0100 5618149 Computational neuroanatomy of speech production http://www.medworm.com/index.php?rid=5618158&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fb29e2TPJHqM%2Fnrn3158 Nature Reviews Neuroscience 13, 135 (2012). doi:10.1038/nrn3158 Author: Gregory Hickok Speech production has been studied predominantly from within two traditions, psycholinguistics and motor control. These traditions have rarely interacted, and the resulting chasm between these approaches seems to reflect a level of analysis difference: whereas motor control is concerned with lower-level articulatory control, psycholinguistics focuses (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618158 Thu, 05 Jan 2012 05:00:00 +0100 5618158 Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration http://www.medworm.com/index.php?rid=5618154&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FaZBn67SWKbw%2Fnrn3156 Authors: Zu-Hang Sheng & Qian Cai Mitochondria have a number of essential roles in neuronal function. Their complex mobility patterns within neurons are characterized by frequent changes in direction. Mobile mitochondria can become stationary or pause in regions that have a high metabolic demand and can move again rapidly in response (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618154 Thu, 05 Jan 2012 05:00:00 +0100 5618154 Synaptic plasticity: Ubiquitin activates synaptic plasticity http://www.medworm.com/index.php?rid=5618146&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FM_4VyghjNGE%2Fnrn3175 Nature Reviews Neuroscience 13, 73 (2012). doi:10.1038/nrn3175 Author: Katherine Whalley NEURL1A-mediated ubiquitylation of CPEB3 alters its activity and regulates hippocampal synaptic plasticity and memory formation. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618146 Thu, 05 Jan 2012 05:00:00 +0100 5618146 Sensory transduction: How TRPs discriminate between different stimuli http://www.medworm.com/index.php?rid=5618148&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FVJ7Wnzzer44%2Fnrn3173 Nature Reviews Neuroscience 13, 74 (2012). doi:10.1038/nrn3173 Author: Sian Lewis Localized expression of different TRP channel isoforms determines behavioural outcomes to different stimuli. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618148 Wed, 21 Dec 2011 05:00:00 +0100 5618148 Neuronal circuits: The sound of fear http://www.medworm.com/index.php?rid=5618141&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FL9zmwogf5JA%2Fnrn3172 Nature Reviews Neuroscience 13, 72 (2012). doi:10.1038/nrn3172 Author: Monica Hoyos Flight A disinhibitory circuit in the mouse auditory cortex mediates fear conditioning to sounds. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5618141 Wed, 21 Dec 2011 05:00:00 +0100 5618141 Our focus on the pharmacogenetics of CRF1 antagonists is simply because they are in clinical development http://www.medworm.com/index.php?rid=5521721&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fxy4lOo7ceT0%2Fnrn3110-c2 Nature Reviews Neuroscience 13, 70 (2012). doi:10.1038/nrn3110-c2 Author: Markus Heilig We recently reviewed accumulating evidence that pharmacotherapies for alcohol addiction will have to be personalized, with the genetic make-up of the individual probably being one of the key variables for identifying responsive patients (Pharmacogenetic approaches to the treatment of alcohol addiction. Nature Rev. Neurosci.12 (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521721 Tue, 20 Dec 2011 05:00:00 +0100 5521721 Corticotropin-releasing factor: innocent until proven guilty http://www.medworm.com/index.php?rid=5521720&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fs8Dnnnqg9Jo%2Fnrn3110-c1 Authors: William J. Giardino & Andrey E. Ryabinin The recent Review article by Heilig et al. (Pharmacogenetic approaches to the treatment of alcohol addiction. Nature Rev. Neurosci.12, 670–684 (2011)) expertly discussed strategies towards the development of therapeutics for alcoholism. However, we noticed a (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521720 Tue, 20 Dec 2011 05:00:00 +0100 5521720 Imaging hippocampal subregions with in vivo MRI: advances and limitations http://www.medworm.com/index.php?rid=5521719&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F4p_XhW_ijcY%2Fnrn3085-c1 Authors: Niels M. van Strien, Marius Widerøe, Wilma D. J. van de Berg & Harry B. M. Uylings In their recent Review article (A pathophysiological framework of hippocampal dysfunction in ageing and disease. Nature Rev. Neurosci.12, 585–601 (2011)), Small et al. present a compelling framework for differentiating hippocampal disorders based on the selective (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521719 Tue, 20 Dec 2011 05:00:00 +0100 5521719 Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses http://www.medworm.com/index.php?rid=5521714&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FosxaNY7K3_M%2Fnrn3125 Authors: Emmanuel Eggermann, Iancu Bucurenciu, Sarit Pati Goswami & Peter Jonas The physical distance between presynaptic Ca2+ channels and the Ca2+ sensors that trigger exocytosis of neurotransmitter-containing vesicles is a key determinant of the signalling properties of synapses in the nervous system. Recent functional analysis indicates that in some fast central synapses, (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521714 Tue, 20 Dec 2011 05:00:00 +0100 5521714 Psychiatric disorders: Multiple pathways to DISC1-related disease? http://www.medworm.com/index.php?rid=5521712&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F0n2bvjbv4OU%2Fnrn3166 Nature Reviews Neuroscience 13, 4 (2012). doi:10.1038/nrn3166 Author: Darran Yates Two new studies suggest mechanisms whereby variants of DISC1 affect neurodevelopment in the immature and adult mammalian brain. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521712 Tue, 20 Dec 2011 05:00:00 +0100 5521712 Learning and memory: Channelling spatial information http://www.medworm.com/index.php?rid=5521711&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FTW3LvXxE7Ws%2Fnrn3164 Nature Reviews Neuroscience 13, 4 (2012). doi:10.1038/nrn3164 Author: Leonie Welberg HCN1 channels regulate the size and stability of grid and place cells (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521711 Tue, 20 Dec 2011 05:00:00 +0100 5521711 Neurodevelopmental disorders: A fragile synaptic balance http://www.medworm.com/index.php?rid=5521710&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FBwWk8BkxMl4%2Fnrn3163 Nature Reviews Neuroscience 13, 3 (2012). doi:10.1038/nrn3163 Author: Katherine Whalley Mutations that cause fragile X syndrome and tuberous sclerosis shift the balance of mGluR5 signalling and synaptic protein synthesis in opposite directions. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521710 Tue, 20 Dec 2011 05:00:00 +0100 5521710 Addiction: NR2B — a target for preventing drug relapse? http://www.medworm.com/index.php?rid=5521708&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F-fDFPorbN2A%2Fnrn3162 Nature Reviews Neuroscience 13, 2 (2012). doi:10.1038/nrn3162 Author: Monica Hoyos Flight The propensity for drug relapse has been associated with cognitive impairments in the prefrontal cortex. Here, the authors examined changes in synaptic plasticity during relapse in a rat model of heroin addiction. They found that there was an increase in the long-term potentiation-like synaptic strength (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521708 Tue, 20 Dec 2011 05:00:00 +0100 5521708 Behavioural neuroscience: Curbing sweet cravings http://www.medworm.com/index.php?rid=5521707&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FAT8qjTPfTiQ%2Fnrn3161 In this study, the authors examined the reward value of sweeteners in mice by assessing the animals' preferences for sweeteners compared to lick-induced optogenetic activation of midbrain dopaminergic neurons. They found that mice preferred optogenetic stimulation to the artificial sweetener sucralose, but not to sucrose. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521707 Tue, 20 Dec 2011 05:00:00 +0100 5521707 Neuropharmacology: Striking the right balance between Gi and Gq signalling http://www.medworm.com/index.php?rid=5521706&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FKM81vg85AdI%2Fnrn3160 Nature Reviews Neuroscience 13, 2 (2012). doi:10.1038/nrn3160 Author: Monica Hoyos Flight A new study explains why some inhibitors of the serotonin Gq protein-coupled receptor 2AR (such as clozapine), but not others (such as ritanserin), have antipsychotic actions. The authors showed that 2AR can form a heteromeric complex with metabotropic glutamate receptor 2 (mGluR2) — (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521706 Tue, 20 Dec 2011 05:00:00 +0100 5521706 Perception: Excitability modulates synaesthesia http://www.medworm.com/index.php?rid=5521705&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FpV9gJWemDd0%2Fnrn3159 Nature Reviews Neuroscience 13, 2 (2012). doi:10.1038/nrn3159 Author: Monica Hoyos Flight Synaesthetes who experience colours when perceiving or representing numbers exhibit structural and functional differences in cortical areas that are involved in number and colour processing compared to non-synaesthetes. Using transcranial magnetic stimulation or transcranial direct current stimulation, the authors showed that in humans, grapheme-colour synaesthesia (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521705 Tue, 20 Dec 2011 05:00:00 +0100 5521705 Neurodevelopmental disorders: Getting with the reprogram http://www.medworm.com/index.php?rid=5521703&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FszW7LalXIJU%2Fnrn3167 Nature Reviews Neuroscience 13, 1 (2012). doi:10.1038/nrn3167 Author: Darran Yates A cellular reprogramming approach reveals that Timothy syndrome, which may be associated with symptoms of autism, is linked to impaired cortical neuron differentiation and abnormal catecholamine signalling. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521703 Tue, 20 Dec 2011 05:00:00 +0100 5521703 Direct electrical stimulation of human cortex — the gold standard for mapping brain functions? http://www.medworm.com/index.php?rid=5521718&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F_zGE6hxyhKA%2Fnrn3140 Authors: Svenja Borchers, Marc Himmelbach, Nikos Logothetis & Hans-Otto Karnath Despite its clinical relevance, direct electrical stimulation (DES) of the human brain is surprisingly poorly understood. Although we understand several aspects of electrical stimulation at the cellular level, surface DES evokes a complex summation effect in a large volume of brain tissue, and the effect (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521718 Wed, 30 Nov 2011 05:00:00 +0100 5521718 Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration http://www.medworm.com/index.php?rid=5521716&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FoE172fvJoLE%2Fnrn3121 Authors: Edward B. Lee, Virginia M.-Y. Lee & John Q. Trojanowski RNA-binding proteins, and in particular TAR DNA-binding protein 43 (TDP43), are central to the pathogenesis of motor neuron diseases and related neurodegenerative disorders. Studies on human tissue have implicated several possible mechanisms of disease and experimental studies are now attempting to determine whether TDP43-mediated neurodegeneration (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521716 Wed, 30 Nov 2011 05:00:00 +0100 5521716 The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission http://www.medworm.com/index.php?rid=5521715&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FZiF9lCE_5lo%2Fnrn3138 Authors: Maurizio Popoli, Zhen Yan, Bruce S. McEwen & Gerard Sanacora Mounting evidence suggests that acute and chronic stress, especially the stress-induced release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal cortex and the hippocampus, thereby influencing some aspects of cognitive processing. In addition, dysfunction of glutamatergic neurotransmission is increasingly considered to be a (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521715 Wed, 30 Nov 2011 05:00:00 +0100 5521715 Neurotransmission: Dissecting co-transmission in the striatum http://www.medworm.com/index.php?rid=5521713&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FITh87yl3cWA%2Fnrn3153 Nature Reviews Neuroscience 13, 5 (2012). doi:10.1038/nrn3153 Author: Monica Hoyos Flight Some of the functions attributed to striatal cholinergic neurons, such as spontaneous locomotor activity and rewarding response to cocaine, are actually mediated by the release of glutamate. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521713 Wed, 30 Nov 2011 05:00:00 +0100 5521713 Neural development: From floorplate to function http://www.medworm.com/index.php?rid=5521704&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fa2kzzCQvCtg%2Fnrn3157 Nature Reviews Neuroscience 13, 2 (2012). doi:10.1038/nrn3157 Author: Sian Lewis A new study demonstrates a method by which dopaminergic neurons can be reliably produced from stem cells, which when transplanted into damaged dopaminergic tissue, integrate into the host tissue to produce functional recovery. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521704 Wed, 30 Nov 2011 05:00:00 +0100 5521704 Normalization as a canonical neural computation http://www.medworm.com/index.php?rid=5521717&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fk8hCaWqFMVI%2Fnrn3136 Authors: Matteo Carandini & David J. Heeger There is increasing evidence that the brain relies on a set of canonical neural computations, repeating them across brain regions and modalities to apply similar operations to different problems. A promising candidate for such a computation is normalization, in which the responses of neurons are (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521717 Wed, 23 Nov 2011 05:00:00 +0100 5521717 Neuronal networks: In the rich club http://www.medworm.com/index.php?rid=5521709&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FuKZT_7tgYJc%2Fnrn3152 Nature Reviews Neuroscience 13, 3 (2012). doi:10.1038/nrn3152 Author: Katherine Whalley A 'rich club' of interconnected brain regions is crucial for global brain network function. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5521709 Wed, 23 Nov 2011 05:00:00 +0100 5521709 A response to Pellicano et al. http://www.medworm.com/index.php?rid=5419631&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FF67TRPFD-4w%2Fnrn3113-c2 Authors: Pat Walsh, Mayada Elsabbagh, Patrick Bolton & Ilina Singh In our examination of the scientific, social and ethical implications of research into autism biomarkers we called for a widespread debate involving many diverse parties and including, importantly, scientists and members of the autism community and their carers (In search of biomarkers for autism: scientific, (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419631 Fri, 18 Nov 2011 05:00:00 +0100 5419631 Engaging, not excluding: a response to Walsh et al. http://www.medworm.com/index.php?rid=5419630&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F-ExM2QX4E64%2Fnrn3113-c1 Authors: Elizabeth Pellicano, Ari Ne'eman & Marc Stears Although we warmly welcome efforts to outline the ethical challenges raised by the search for autism biomarkers, the recent Perspective article by Walsh et al. (In search of biomarkers for autism: scientific, social and ethical challenges. Nature Rev. Neurosci.12, 603–612 (2011)) (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419630 Fri, 18 Nov 2011 05:00:00 +0100 5419630 Brains on video games http://www.medworm.com/index.php?rid=5419629&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FVBnp-6HqpMg%2Fnrn3135 Authors: Daphne Bavelier, C. Shawn Green, Doug Hyun Han, Perry F. Renshaw, Michael M. Merzenich & Douglas A. Gentile The popular press is replete with stories about the effects of video and computer games on the brain. Sensationalist headlines claiming that video games 'damage the brain' or 'boost brain power' do not do justice to the complexities and limitations of the studies involved, and (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419629 Fri, 18 Nov 2011 05:00:00 +0100 5419629 Linking neurodevelopmental and synaptic theories of mental illness through DISC1 http://www.medworm.com/index.php?rid=5419625&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FfJ3T3ZwIIig%2Fnrn3120 Authors: Nicholas J. Brandon & Akira Sawa Recent advances in our understanding of the underlying genetic architecture of psychiatric disorders has blown away the diagnostic boundaries that are defined by currently used diagnostic manuals. The disrupted in schizophrenia 1 (DISC1) gene was originally discovered at the breakpoint of an inherited (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419625 Fri, 18 Nov 2011 05:00:00 +0100 5419625 Neuroimmunology: Does multiple sclerosis originate in the gut? http://www.medworm.com/index.php?rid=5419624&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FkS28xjO81eI%2Fnrn3150 Nature Reviews Neuroscience 12, 706 (2011). doi:10.1038/nrn3150 Author: Darran Yates Autoreactive T and B cells may have important roles in multiple sclerosis, but what triggers autoreactivity is unclear. Here, the authors examined a relapsing–remitting variant of spontaneously developing murine experimental autoimmune encephalomyelitis (EAE). In this multiple sclerosis model, disease is driven by T cells that (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419624 Fri, 18 Nov 2011 05:00:00 +0100 5419624 Sleep: Visualizing dreams http://www.medworm.com/index.php?rid=5419623&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FkMZjIU0B37Y%2Fnrn3149 Nature Reviews Neuroscience 12, 706 (2011). doi:10.1038/nrn3149 Author: Darran Yates In lucid dreaming, individuals become aware that they are dreaming and are able to control their dreamed actions. Here, lucid dreamers were instructed to perform a hand clenching task while undergoing functional MRI or near-infrared spectroscopy. Hand clenching during dreaming was associated with neural activity (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419623 Fri, 18 Nov 2011 05:00:00 +0100 5419623 Metabolism: Another path to prostaglandins http://www.medworm.com/index.php?rid=5419622&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F9IGca6hCJVQ%2Fnrn3148 Nature Reviews Neuroscience 12, 706 (2011). doi:10.1038/nrn3148 Author: Darran Yates Prostaglandins have various physiological effects, including activation of inflammatory pathways. They are derived from arachidonic acid, the synthesis of which is believed to be mainly regulated by phospholipase A2. Nomura et al. show that monoacylglycerol lipase (MAGL) mediates an alternative prostaglandin biosynthetic pathway. Moreover, (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419622 Fri, 18 Nov 2011 05:00:00 +0100 5419622 Neurodegenerative disease: A pathogenic role for ARC? http://www.medworm.com/index.php?rid=5419621&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F8kgATSjT6ew%2Fnrn3147 Nature Reviews Neuroscience 12, 706 (2011). doi:10.1038/nrn3147 Author: Darran Yates Amyloid-β, which is implicated in the pathogenesis of Alzheimer's disease, is generated from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretase, aprocessthatisbelievedtooccurinendosomes. Neuronalactivitycanincreaseamyloid-β generationbuttheunderlyingmechanismisunclear. Here, theauthorsshowthatdepletionofactivity-regulatedcytoskeleton-associatedprotein (ARC) inAlzheimer'sdiseasemicepreventsactivity-inducedamyloid-β production. Moreover, ARCcausesincreasedcolocalizationofAPPandγ-secretaseinpostsynapticendosomes, potentiallyfacilitatingAPPcleavageandhenceamyloid-β production. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419621 Fri, 18 Nov 2011 05:00:00 +0100 5419621 Gene expression: The dynamics of the brain transcriptome revealed http://www.medworm.com/index.php?rid=5419615&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FuNhnhzPIBHY%2Fnrn3145 Nature Reviews Neuroscience 12, 703 (2011). doi:10.1038/nrn3145 Author: Monica Hoyos Flight The greatest differences in brain gene expression patterns are observed between brain regions and over time, rather than between sexes, ethnicities or individuals. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419615 Fri, 18 Nov 2011 05:00:00 +0100 5419615 From the editors http://www.medworm.com/index.php?rid=5419614&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fceo6K9oNIdM%2Fnrn3146 Nature Reviews Neuroscience 12, 701 (2011). doi:10.1038/nrn3146 The first two articles in this issue have a common theme — the pathophysiology of disease. In a Review on page 707, Brandon and Sawa examine the role of disrupted in schizophrenia 1 (DISC1) in the developing and mature brain, and discuss how knowledge (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419614 Fri, 18 Nov 2011 05:00:00 +0100 5419614 Dendrites: There's a NAK to branching out http://www.medworm.com/index.php?rid=5419620&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FfrynyEVnA7g%2Fnrn3143 Nature Reviews Neuroscience 12, 706 (2011). doi:10.1038/nrn3143 Author: Darran Yates Numb-associated kinase activity is crucial for higher-order dendrite aborization. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419620 Wed, 09 Nov 2011 05:00:00 +0100 5419620 Learning and memory: CA1 triggers the trace http://www.medworm.com/index.php?rid=5419619&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FLNBpeJIMc3A%2Fnrn3144 Learning and memory: CA1 triggers the trace Nature Reviews Neuroscience 12, 705 (2011). doi:10.1038/nrn3144 Author: Leonie Welberg The hippocampus is normally involved in, but is not required for, activation of neocortical memory traces. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419619 Wed, 09 Nov 2011 05:00:00 +0100 5419619 Synaptic plasticity: Tuning electrical synapses http://www.medworm.com/index.php?rid=5419618&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FRQVL1lo2q0g%2Fnrn3142 Nature Reviews Neuroscience 12, 705 (2011). doi:10.1038/nrn3142 Author: Katherine Whalley Bursting activity in electrically coupled neurons induces long term depression at gap-junctional synapses. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419618 Wed, 09 Nov 2011 05:00:00 +0100 5419618 Virtual reality in neuroscience research and therapy http://www.medworm.com/index.php?rid=5419628&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FUiW_-qsSdek%2Fnrn3122 Authors: Corey J. Bohil, Bradly Alicea & Frank A. Biocca Virtual reality (VR) environments are increasingly being used by neuroscientists to simulate natural events and social interactions. VR creates interactive, multimodal sensory stimuli that offer unique advantages over other approaches to neuroscientific research and applications. VR's compatibility with imaging technologies such as functional MRI allows (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419628 Thu, 03 Nov 2011 04:00:00 +0100 5419628 Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders http://www.medworm.com/index.php?rid=5419626&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FHjiYLrkRRLc%2Fnrn3114 Nature Reviews Neuroscience 12, 723 (2011). doi:10.1038/nrn3114 Author: Berislav V. Zlokovic The neurovascular unit (NVU) comprises brain endothelial cells, pericytes or vascular smooth muscle cells, glia and neurons. The NVU controls blood–brain barrier (BBB) permeability and cerebral blood flow, and maintains the chemical composition of the neuronal 'milieu', which is required for proper functioning of neuronal (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419626 Thu, 03 Nov 2011 04:00:00 +0100 5419626 Ignoring the bad news... http://www.medworm.com/index.php?rid=5419617&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FKuZdZwsAUbc%2Fnrn3141 Nature Reviews Neuroscience 12, 704 (2011). doi:10.1038/nrn3141 Author: Sian Lewis The phenomenon of 'unrealistic optimism' is a common human trait. A new functional MRI study, led by Raymond Dolan from University College London, UK, shows that extreme optimists have a reduced ability to adjust their predictions when they receive negative information that challenges their beliefs (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419617 Thu, 03 Nov 2011 04:00:00 +0100 5419617 Neurodegenerative disease: CRF is the culprit http://www.medworm.com/index.php?rid=5419616&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FbsCn-BkPq8s%2Fnrn3139 Nature Reviews Neuroscience 12, 704 (2011). doi:10.1038/nrn3139 Author: Leonie Welberg Chronic stress exacerbates tauopathy, memory impairment and neurodegeneration in a mouse model of Alzheimer's disease via a CRF1 receptor-dependent mechanism. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419616 Thu, 03 Nov 2011 04:00:00 +0100 5419616 Principles of sensorimotor learning http://www.medworm.com/index.php?rid=5419627&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FX5UAiJtfRFQ%2Fnrn3112 Authors: Daniel M. Wolpert, Jörn Diedrichsen & J. Randall Flanagan The exploits of Martina Navratilova and Roger Federer represent the pinnacle of motor learning. However, when considering the range and complexity of the processes that are involved in motor learning, even the mere mortals among us exhibit abilities that are impressive. We exercise these abilities (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5419627 Thu, 27 Oct 2011 04:00:00 +0100 5419627 Pharmacogenetic approaches to the treatment of alcohol addiction http://www.medworm.com/index.php?rid=5332728&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FTG7-2jEWlf8%2Fnrn3110 Authors: Markus Heilig, David Goldman, Wade Berrettini & Charles P. O'Brien Addictive disorders are partly heritable, chronic, relapsing conditions that account for a tremendous disease burden. Currently available addiction pharmacotherapies are only moderately successful, continue to be viewed with considerable scepticism outside the scientific community and have not become widely adopted as treatments. More effective medical (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332728 Thu, 20 Oct 2011 04:00:00 +0100 5332728 Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications http://www.medworm.com/index.php?rid=5332727&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FKWQZqcNqaLs%2Fnrn3119 Authors: Rita Z. Goldstein & Nora D. Volkow The loss of control over drug intake that occurs in addiction was initially believed to result from disruption of subcortical reward circuits. However, imaging studies in addictive behaviours have identified a key involvement of the prefrontal cortex (PFC) both through its regulation of limbic reward (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332727 Thu, 20 Oct 2011 04:00:00 +0100 5332727 Common cellular and molecular mechanisms in obesity and drug addiction http://www.medworm.com/index.php?rid=5332726&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FCwvy2TLfMEI%2Fnrn3105 Nature Reviews Neuroscience 12, 638 (2011). doi:10.1038/nrn3105 Author: Paul J. Kenny The hedonic properties of food can stimulate feeding behaviour even when energy requirements have been met, contributing to weight gain and obesity. Similarly, the hedonic effects of drugs of abuse can motivate their excessive intake, culminating in addiction. Common brain substrates regulate the hedonic properties (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332726 Thu, 20 Oct 2011 04:00:00 +0100 5332726 Addiction: from mechanisms to treatment http://www.medworm.com/index.php?rid=5332724&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fp9bjBeDxIKg%2Fnrn3131 Nature Reviews Neuroscience 12, 621 (2011). doi:10.1038/nrn3131 Author: Leonie Welberg It needs no explanation that addiction is an extremely serious problem, considering its impact on both health and society. Unsurprisingly, addiction is a major focus of neuroscience research, and the molecular, cellular and circuit mechanisms underlying addiction are slowly beginning to be understood. Despite these (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332724 Thu, 20 Oct 2011 04:00:00 +0100 5332724 Neurogenetics: Expanding ALS and FTD genetics http://www.medworm.com/index.php?rid=5332719&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fku1KbI_3Tu0%2Fnrn3134 Nature Reviews Neuroscience 12, 616 (2011). doi:10.1038/nrn3134 Author: Darran Yates Amyotrophic lateral sclerosis (ALS) and frontal temporal dementia (FTD) can occur in the same family with an autosomal-dominant pattern of heritance that is linked to chromosome 9p21. Now, two studies independently report that a hexanucleotide repeat expansion in the non-coding region of C9ORF72 causes (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332719 Thu, 20 Oct 2011 04:00:00 +0100 5332719 Olfactory coding: Smell gets organized! http://www.medworm.com/index.php?rid=5332718&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fd_WSlPBqO8c%2Fnrn3133 Nature Reviews Neuroscience 12, 616 (2011). doi:10.1038/nrn3133 Author: Sian Lewis The receptive surfaces for senses such as hearing (cochlea) and vision (retina) are organized along axes of sensory perception, but whether a similar type of organization is present in the olfactory epithelium is unknown. The authors measured the response of sensory receptors in the adult (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332718 Thu, 20 Oct 2011 04:00:00 +0100 5332718 Neuropharmacology: Pain, pain, go away http://www.medworm.com/index.php?rid=5332717&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F56Ku3OVvOy8%2Fnrn3132 Nature Reviews Neuroscience 12, 616 (2011). doi:10.1038/nrn3132 Author: Sian Lewis Placebo responses to painful stimuli are mediated by both opioid and non-opioid mechanisms, and the latter are poorly understood. Here, Benedetti and colleagues examined the role of the endocannabinoid system in such responses. The authors conditioned individuals, who were undergoing daily pain tolerance tests, to (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332717 Thu, 20 Oct 2011 04:00:00 +0100 5332717 Neural development: Neurogenesis ends near the beginning http://www.medworm.com/index.php?rid=5332716&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FLuPm8og4J7Q%2Fnrn3128 Nature Reviews Neuroscience 12, 616 (2011). doi:10.1038/nrn3128 Author: Sian Lewis Neurogenesis in the subventricular zone is robust in infancy, with cells migrating to olfactory regions and also to the prefrontal cortex, but this declines sharply before the age of two. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332716 Thu, 20 Oct 2011 04:00:00 +0100 5332716 Neurodevelopmental disorders: Mice that mirror autism http://www.medworm.com/index.php?rid=5332715&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FynXhLwstoH0%2Fnrn3129 Nature Reviews Neuroscience 12, 615 (2011). doi:10.1038/nrn3129 Author: Leonie Welberg Mice lacking Cntnap2 show abnormal neuronal migration, asynchronous firing patterns and have an autism-like phenotype that can be partially normalized by treatment with risperidone. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332715 Thu, 20 Oct 2011 04:00:00 +0100 5332715 From the editors http://www.medworm.com/index.php?rid=5332714&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FpsB3L0BWWx8%2Fnrn3130 Nature Reviews Neuroscience 12, 613 (2011). doi:10.1038/nrn3130 This special Focus issue of Nature Reviews Neuroscience explores our current understanding of addiction. The issue opens with a Review on page 623 by Robison and Nestler that examines how drugs of abuse can alter the transcriptional potential of genes. This phenomenon may (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332714 Thu, 20 Oct 2011 04:00:00 +0100 5332714 Transcriptional and epigenetic mechanisms of addiction http://www.medworm.com/index.php?rid=5332725&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FIa3LyOl-tOo%2Fnrn3111 Authors: Alfred J. Robison & Eric J. Nestler Investigations of long-term changes in brain structure and function that accompany chronic exposure to drugs of abuse suggest that alterations in gene regulation contribute substantially to the addictive phenotype. Here, we review multiple mechanisms by which drugs alter the transcriptional potential of genes. These mechanisms (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332725 Wed, 12 Oct 2011 04:00:00 +0100 5332725 Synaptic plasticity: Transporting memories http://www.medworm.com/index.php?rid=5332721&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fnk7axrztPjg%2Fnrn3127 Nature Reviews Neuroscience 12, 617 (2011). doi:10.1038/nrn3127 Author: Darran Yates KIBRA may modulate learning and memory through the regulation of AMPA receptor trafficking and synaptic plasticity. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332721 Wed, 12 Oct 2011 04:00:00 +0100 5332721 Learning and memory: Small molecule, big hindrance to memory http://www.medworm.com/index.php?rid=5332720&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F83KWo763cAY%2Fnrn3126 Nature Reviews Neuroscience 12, 617 (2011). doi:10.1038/nrn3126 Author: Monica Hoyos Flight microRNA-34c interferes with memory consolidation in the mouse hippocampus and could be a novel target for the treatment of cognitive impairment. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332720 Wed, 12 Oct 2011 04:00:00 +0100 5332720 On the speed of cocaine http://www.medworm.com/index.php?rid=5332731&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F_3n1QTPGRQw%2Fnrn3043-c2 Authors: Roy A. Wise & Eugene A. Kiyatkin Brandon Aragona reasserts an argument that we questioned in our Perspective on the relative latencies of conditioned and unconditioned cocaine reward signals (Differentiating the rapid actions of cocaine. Nature Rev. Neurosci.12, 479–484 (2011)) and (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332731 Wed, 05 Oct 2011 04:00:00 +0100 5332731 The regional specificity of rapid actions of cocaine http://www.medworm.com/index.php?rid=5332730&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FJX-3NweGnPc%2Fnrn3043-c1 Nature Reviews Neuroscience 12, 700 (2011). doi:10.1038/nrn3043-c1 Author: Brandon J. Aragona In their recent Perspective article, Roy Wise and Eugene Kiyatkin conclude that, “the primary, unconditioned rewarding effects of cocaine in naive animals involves the blockade of dopamine reuptake rather than stimulation of dopamine release” (Differentiating the rapid actions of cocaine. Nature Rev. Neurosci. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332730 Wed, 05 Oct 2011 04:00:00 +0100 5332730 Opiate versus psychostimulant addiction: the differences do matter http://www.medworm.com/index.php?rid=5332729&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FXrtubgO9c0c%2Fnrn3104 Authors: Aldo Badiani, David Belin, David Epstein, Donna Calu & Yavin Shaham The publication of the psychomotor stimulant theory of addiction in 1987 and the finding that addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 have led to a predominance of psychobiological theories that consider addiction to opiates and addiction to psychostimulants as (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332729 Wed, 05 Oct 2011 04:00:00 +0100 5332729 Pain: A prickly solution? http://www.medworm.com/index.php?rid=5332723&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F6S8_4HtkJi8%2Fnrn3124 Nature Reviews Neuroscience 12, 618 (2011). doi:10.1038/nrn3124 Author: Monica Hoyos Flight A new study reveals an unexpected role for Hedgehog signalling in thermal allodynia and hyperalgesia. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332723 Wed, 05 Oct 2011 04:00:00 +0100 5332723 Sensory systems: Charting vomeronasal receptor function http://www.medworm.com/index.php?rid=5332722&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fdc86Zi_gsM0%2Fnrn3123 Nature Reviews Neuroscience 12, 618 (2011). doi:10.1038/nrn3123 Author: Katherine Whalley Identification of the chemical cues that activate specific vomeronasal receptors sheds light on the organization of the vomeronasal system. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5332722 Wed, 05 Oct 2011 04:00:00 +0100 5332722 In search of biomarkers for autism: scientific, social and ethical challenges http://www.medworm.com/index.php?rid=5235345&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FVb8FX2-dNmQ%2Fnrn3113 Authors: Pat Walsh, Mayada Elsabbagh, Patrick Bolton & Ilina Singh There is widespread hope that the discovery of valid biomarkers for autism will both reveal the causes of autism and enable earlier and more targeted methods for diagnosis and intervention. However, growing enthusiasm about recent advances in this area of autism research needs to be (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235345 Tue, 20 Sep 2011 04:00:00 +0100 5235345 Diencephalic and brainstem mechanisms in migraine http://www.medworm.com/index.php?rid=5235343&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FkRp9QAwYgFg%2Fnrn3057 Authors: Simon Akerman, Philip R. Holland & Peter J. Goadsby Migraine is a common and complex brain disorder. Although it is clear that head pain is a key manifestation of the disorder for most patients, what drives the activation of neuronal pain pathways in susceptible patients is less obvious. There is growing evidence that migraine (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235343 Tue, 20 Sep 2011 04:00:00 +0100 5235343 In brief http://www.medworm.com/index.php?rid=5235341&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FqLCvugjZKek%2Fnrn3118 Nature Reviews Neuroscience 12, 551 (2011). doi:10.1038/nrn3118 NeurogeneticsMED23 mutation links intellectual disability to dysregulation of immediate early gene expressionHashimoto, S.et al. Science333, 1161–1163 (2011)MED23 protein is a component of the mediator complex and is involved in immediate early (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235341 Tue, 20 Sep 2011 04:00:00 +0100 5235341 Ageing: Ageing, it's in the blood http://www.medworm.com/index.php?rid=5235333&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F0rlN6ho8XVU%2Fnrn3116 Nature Reviews Neuroscience 12, 547 (2011). doi:10.1038/nrn3116 Author: Darran Yates Molecular changes in blood that occur with ageing may be partly responsible for the decreased neurogenesis and cognitive deficits that are observed in aged mice. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235333 Tue, 20 Sep 2011 04:00:00 +0100 5235333 From the editors http://www.medworm.com/index.php?rid=5235332&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FRocuXA_lhI4%2Fnrn3117 Nature Reviews Neuroscience 12, 545 (2011). doi:10.1038/nrn3117 Much of neuroscience research is motivated by diseases. Some major research questions pertain to vulnerability: what brain areas or systems are vulnerable to perturbations that trigger dysfunction? And which individuals are vulnerable to developing a disease? The articles in this issue touch upon these questions. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235332 Tue, 20 Sep 2011 04:00:00 +0100 5235332 Behaviour: 'Chillax' with probiotics http://www.medworm.com/index.php?rid=5235337&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F3JnXeUPi2zc%2Fnrn3115 Nature Reviews Neuroscience 12, 549 (2011). doi:10.1038/nrn3115 Author: Sian Lewis Chronic ingestion of probiotic ('good') bacteria can reduce anxiety, an effect that seems likely to be mediated via the vagus nerve. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235337 Wed, 14 Sep 2011 04:00:00 +0100 5235337 Natural moment-to-moment signal variability and stochastic facilitation http://www.medworm.com/index.php?rid=5235347&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FVICY83zjtyU%2Fnrn3061-c2 Authors: Mark D. McDonnell & Lawrence M. Ward We have recently provided an Opinion article (The benefits of noise in neural systems: bridging theory and experiment. Nat. Rev. Neurosci.12, 415–426 (2011)) that highlights the benefits of stochastic resonance to information processing.We (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235347 Wed, 07 Sep 2011 04:00:00 +0100 5235347 Moment-to-moment signal variability in the human brain can inform models of stochastic facilitation now http://www.medworm.com/index.php?rid=5235346&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FvX60jmwYjtI%2Fnrn3061-c1 Authors: Douglas D. Garrett, Anthony R. McIntosh & Cheryl L. Grady In their recent Opinion article (The benefits of noise in neural systems: bridging theory and experiment. Nature Rev. Neurosci.12, 415–425 (2011)), McDonnell and Ward make several compelling arguments highlighting the benefits of 'noise' in (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235346 Wed, 07 Sep 2011 04:00:00 +0100 5235346 A pathophysiological framework of hippocampal dysfunction in ageing and disease http://www.medworm.com/index.php?rid=5235344&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F1RqpwjDj1kc%2Fnrn3085 Authors: Scott A. Small, Scott A. Schobel, Richard B. Buxton, Menno P. Witter & Carol A. Barnes The hippocampal formation has been implicated in a growing number of disorders, from Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the hippocampal formation, a complex circuit that spans the temporal lobes, be involved in a range of such phenotypically diverse and (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235344 Wed, 07 Sep 2011 04:00:00 +0100 5235344 In brief http://www.medworm.com/index.php?rid=5235336&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FhEZCJTJ5n1E%2Fnrn3107 Nature Reviews Neuroscience 12, 549 (2011). doi:10.1038/nrn3107 GliaAstrocytes are endogenous regulators of basal transmission at central synapsesPanatier, A.et al. Cell18 Aug 2011 (doi:10.1016/j.cell.2011.07.022)Astrocytes are known to modulate the activity of neural networks, but their contribution to basal neurotransmission was unclear. Here, the (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235336 Wed, 07 Sep 2011 04:00:00 +0100 5235336 Epigenetics: From father to son http://www.medworm.com/index.php?rid=5235335&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FgNN-xoDOzLA%2Fnrn3109 Nature Reviews Neuroscience 12, 548 (2011). doi:10.1038/nrn3109 Author: Katherine Whalley The effects of prenatal stress on sex differences in brain gene expression and behaviour can be transmitted down the paternal lineage to male offspring. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235335 Wed, 07 Sep 2011 04:00:00 +0100 5235335 Linking neural activity and molecular oscillations in the SCN http://www.medworm.com/index.php?rid=5235342&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FWHvG1w61Oyg%2Fnrn3086 Nature Reviews Neuroscience 12, 553 (2011). doi:10.1038/nrn3086 Author: Christopher S. Colwell Neurons in the suprachiasmatic nucleus (SCN) function as part of a central timing circuit that drives daily changes in our behaviour and underlying physiology. A hallmark feature of SCN neuronal populations is that they are mostly electrically silent during the night, start to fire action (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235342 Fri, 02 Sep 2011 04:00:00 +0100 5235342 Neurodegenerative disease: α-synuclein gets a new look http://www.medworm.com/index.php?rid=5235338&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FuO5xFwDUSC8%2Fnrn3106 Nature Reviews Neuroscience 12, 550 (2011). doi:10.1038/nrn3106 Author: Darran Yates A new study shows that in its native state, α-synuclein predominantly exists as an α-helical tetramer rather than an unfolded monomer. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235338 Fri, 02 Sep 2011 04:00:00 +0100 5235338 Synaptic plasticity: A key player in presynaptic plasticity http://www.medworm.com/index.php?rid=5235334&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FXhm5u7_0FxM%2Fnrn3108 Nature Reviews Neuroscience 12, 548 (2011). doi:10.1038/nrn3108 Author: Sian Lewis The synaptic vesicle protein RAB3B seems to have a key role in endocannabinoid-dependent presynaptic long-term depression at hippocampal inhibitory synapses and also in spatial memory retention. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235334 Fri, 02 Sep 2011 04:00:00 +0100 5235334 Spatial coding: Does the brain know how high it is? http://www.medworm.com/index.php?rid=5235340&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FKZO5o7LJBC0%2Fnrn3103 Nature Reviews Neuroscience 12, 550 (2011). doi:10.1038/nrn3103 Author: Katherine Whalley Grid cells and place cells encode little information about vertical position in three-dimensional space. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235340 Wed, 24 Aug 2011 04:00:00 +0100 5235340 Neurotrophic factors: Ride back to the nucleus http://www.medworm.com/index.php?rid=5235339&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FuKUd8OzKqb8%2Fnrn3102 Nature Reviews Neuroscience 12, 550 (2011). doi:10.1038/nrn3102 Author: Monica Hoyos Flight The retrograde transport of signalling endosomes requires the activation of RAC1and cofilin to induce actin depolymerization. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5235339 Wed, 24 Aug 2011 04:00:00 +0100 5235339 Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine http://www.medworm.com/index.php?rid=5158121&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F1ACAjLLyNec%2Fnrn3044 Authors: Andreas Meyer-Lindenberg, Gregor Domes, Peter Kirsch & Markus Heinrichs The neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are evolutionarily highly conserved mediators in the regulation of complex social cognition and behaviour. Recent studies have investigated the effects of OXT and AVP on human social interaction, the genetic mechanisms of inter-individual variation in social neuropeptide (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158121 Thu, 18 Aug 2011 23:00:00 +0100 5158121 Development: Pruning the dendritic tree http://www.medworm.com/index.php?rid=5158118&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FD0qS3Ok0Rvw%2Fnrn3099 Nature Reviews Neuroscience 12, 493 (2011). doi:10.1038/nrn3099 Author: Sian Lewis A novel function for CaMKIIβ has been identified in the mammalian brain whereby it regulates dendritic patterning through phosphorylation of CDC20–APC/C at the centrosome. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158118 Thu, 18 Aug 2011 23:00:00 +0100 5158118 Psychiatric disorders: Down with(out) neurogenesis http://www.medworm.com/index.php?rid=5158117&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FQ6KQ7_Uj3e4%2Fnrn3097 Nature Reviews Neuroscience 12, 492 (2011). doi:10.1038/nrn3097 Author: Leonie Welberg Reducing adult neurogenesis induces depression-like behaviour under stressful conditions. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158117 Thu, 18 Aug 2011 23:00:00 +0100 5158117 Development: Microglia go pruning http://www.medworm.com/index.php?rid=5158116&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FBTOMLj19yEI%2Fnrn3095 Nature Reviews Neuroscience 12, 492 (2011). doi:10.1038/nrn3095 Author: Sian Lewis During the synaptic maturation and elimination phase of hippocampal development, microglia may engulf unwanted synapses, and thus contribute to correct circuit maturation. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158116 Thu, 18 Aug 2011 23:00:00 +0100 5158116 In brief http://www.medworm.com/index.php?rid=5158115&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F-d6cKX2tCCI%2Fnrn3100 Nature Reviews Neuroscience 12, 491 (2011). doi:10.1038/nrn3100 NeuroimmunologyInfiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia poolAjami, B.et al. Nature Neurosci.31 Jul 2011 (doi:10.1038/nn.2887)Resident microglia and macrophages derived from peripheral monocytes accumulate in the CNS in multiple sclerosis (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158115 Thu, 18 Aug 2011 23:00:00 +0100 5158115 Ageing: Rescuing age-related memory loss http://www.medworm.com/index.php?rid=5158113&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FYZzkNKKyKCI%2Fnrn3096 Nature Reviews Neuroscience 12, 490 (2011). doi:10.1038/nrn3096 Author: Monica Hoyos Flight A new study reveals the physiological basis of age-related memory decline and potential means to restore it. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158113 Thu, 18 Aug 2011 23:00:00 +0100 5158113 Psychiatric disorders: Tipping the cortical balance http://www.medworm.com/index.php?rid=5158107&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FIZgFkL3y3AU%2Fnrn3098 Nature Reviews Neuroscience 12, 487 (2011). doi:10.1038/nrn3098 Author: Darran Yates An elevation in the excitation/inhibition ratio in the medial prefrontal cortex leads to impairments in social behaviour and cognition in mice. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158107 Thu, 18 Aug 2011 23:00:00 +0100 5158107 From the editors http://www.medworm.com/index.php?rid=5158106&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FqVyupiq91tI%2Fnrn3101 Nature Reviews Neuroscience 12, 485 (2011). doi:10.1038/nrn3101 Diseases that are difficult to treat are central to three articles in this issue of Nature Reviews Neuroscience.Chronic fatigue syndrome (CFS; also known as myalgic encephalomyelitis or ME) recently attracted renewed attention when a reported link between xenotropic murine leukemia virus-related virus (XMRV) (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158106 Thu, 18 Aug 2011 23:00:00 +0100 5158106 Fly Fisticuffs http://www.medworm.com/index.php?rid=5158123&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FjXON26Ca-Ls%2Fnrn3094 Nature Reviews Neuroscience 12, 544 (2011). doi:10.1038/nrn3094 Author: Sian Lewis Nature Reviews Neuroscience12, 434–43510.1038/nrn3078 (2011)On page 434 of this highlight, the credit for the illustration was incorrectly given. The correct name for the illustrator is Molly Liu. This has been corrected in the online version. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158123 Tue, 09 Aug 2011 23:00:00 +0100 5158123 Cortical state and attention http://www.medworm.com/index.php?rid=5158120&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F5jtLQ1rJmr4%2Fnrn3084 This article will focus on two experimental approaches by which the control of cortical (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158120 Tue, 09 Aug 2011 23:00:00 +0100 5158120 In brief http://www.medworm.com/index.php?rid=5158114&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fg1DH0Q8FF50%2Fnrn3093 Nature Reviews Neuroscience 12, 491 (2011). doi:10.1038/nrn3093 Stem cellsGeneration of isogenic pluripotent stem cells differing exclusively at two early onset parkinson point mutationsSoldner, F.et al. Cell146, 318–331 (2011)It is widely hoped that induced pluripotent stem cells (iPSCs) that are (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158114 Tue, 09 Aug 2011 23:00:00 +0100 5158114 Stem cells: A niche role for DLK1 http://www.medworm.com/index.php?rid=5158110&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F44-F5W89W90%2Fnrn3092 Nature Reviews Neuroscience 12, 489 (2011). doi:10.1038/nrn3092 Author: Katherine Whalley Loss of delta-like homologue 1 (Dlk1) imprinting in the subventricular zone regulates postnatal neurogenesis. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158110 Tue, 09 Aug 2011 23:00:00 +0100 5158110 The neurobiology of gliomas: from cell biology to the development of therapeutic approaches http://www.medworm.com/index.php?rid=5158119&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FhJEun27PFGY%2Fnrn3060 Authors: Manfred Westphal & Katrin Lamszus Gliomas are the most common type of primary brain tumour and are often fast growing with a poor prognosis for the patient. Their complex cellular composition, diffuse invasiveness and capacity to escape therapies has challenged researchers for decades and hampered progress towards an effective treatment. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158119 Tue, 02 Aug 2011 23:00:00 +0100 5158119 Neuronal circuits: Putting rewards into context http://www.medworm.com/index.php?rid=5158112&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FEYdlitszt1o%2Fnrn3090 Nature Reviews Neuroscience 12, 490 (2011). doi:10.1038/nrn3090 Author: Leonie Welberg A multisynaptic pathway from the hippocampal CA3 via the lateral septum to the ventral tegmental area links spatial context to reward. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158112 Tue, 02 Aug 2011 23:00:00 +0100 5158112 Googled brains? http://www.medworm.com/index.php?rid=5158111&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FqCBFqmd4okI%2Fnrn3091 Nature Reviews Neuroscience 12, 490 (2011). doi:10.1038/nrn3091 Author: Sian Lewis The accessibility of an encyclopedia of knowledge at the click of a mouse — thanks to search engines like Google — is reducing our ability to remember information, a new study shows. The research, led by Betsy Sparrow from Columbia University, New York, USA, found (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158111 Tue, 02 Aug 2011 23:00:00 +0100 5158111 Chronic fatigue syndrome: understanding a complex illness http://www.medworm.com/index.php?rid=5158122&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FMGXvLEWtM54%2Fnrn3087 Authors: Stephen T. Holgate, Anthony L. Komaroff, Dennis Mangan & Simon Wessely Chronic fatigue syndrome (CFS) is a debilitating illness that affects many people. It has been marred by controversy, from initial scepticism in the medical community about the existence of the condition itself to continuing disagreements — mainly between some patient advocacy groups on one side, (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158122 Tue, 26 Jul 2011 23:00:00 +0100 5158122 Glia: Death receptor deals blow to remyelination http://www.medworm.com/index.php?rid=5158109&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F001Px7jMo-Y%2Fnrn3088 Nature Reviews Neuroscience 12, 489 (2011). doi:10.1038/nrn3088 Author: Katherine Whalley Death receptor 6 negatively regulates the survival and maturation of oligodendrocytes and limits remyelination. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158109 Tue, 26 Jul 2011 23:00:00 +0100 5158109 Learning and memory: Parallel processing http://www.medworm.com/index.php?rid=5158108&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FhEIeOEuihjI%2Fnrn3089 Nature Reviews Neuroscience 12, 488 (2011). doi:10.1038/nrn3089 Author: Darran Yates Schema-dependent memory formation involves parallel encoding in the hippocampus and in the neocortex. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5158108 Tue, 26 Jul 2011 23:00:00 +0100 5158108 Fighting neurodegeneration with rapamycin: mechanistic insights http://www.medworm.com/index.php?rid=5049776&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FurzT6pxjaGE%2Fnrn3068 Authors: Jordi Bové, Marta Martínez-Vicente & Miquel Vila A growing number of studies point to rapamycin as a pharmacological compound that is able to provide neuroprotection in several experimental models of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease and spinocerebellar ataxia type 3. In addition, rapamycin exerts strong anti-ageing effects in (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049776 Tue, 19 Jul 2011 23:00:00 +0100 5049776 In brief http://www.medworm.com/index.php?rid=5049771&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FXUR1gixjVL4%2Fnrn3082 Nature Reviews Neuroscience 12, 433 (2011). doi:10.1038/nrn3082 AutismDisrupted neural synchronization in toddlers with autismDinstein, I.et al. Neuron70, 218–1225 (2011)Reduced inter-hemispheric synchronization is characteristic of people with autism, but how early these deficits emerge is not known. Using functional MRI (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049771 Tue, 19 Jul 2011 23:00:00 +0100 5049771 Psychiatric disorders: The stress of city life http://www.medworm.com/index.php?rid=5049765&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FYDycwiB_UjM%2Fnrn3079 Nature Reviews Neuroscience 12, 430 (2011). doi:10.1038/nrn3079 Author: Darran Yates Social stress processing in healthy individuals is affected by city living and an urban upbringing (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049765 Tue, 19 Jul 2011 23:00:00 +0100 5049765 Autism: The importance of getting the dose right http://www.medworm.com/index.php?rid=5049764&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F_DvI5Swy6pE%2Fnrn3083 Nature Reviews Neuroscience 12, 429 (2011). doi:10.1038/nrn3083 Author: Leonie Welberg Rare copy number variations explain a relatively large proportion of sporadic cases of autism spectrum disorders. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049764 Tue, 19 Jul 2011 23:00:00 +0100 5049764 From the editors http://www.medworm.com/index.php?rid=5049763&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fw24Pd9IT4bU%2Fnrn3080 Nature Reviews Neuroscience 12, 427 (2011). doi:10.1038/nrn3080 This issue opens on page 437 with a Review by Vila and colleagues on rapamycin, an inhibitor of the kinase mammalian target of rapamycin. This agent holds promise as a treatment for disorders such as Alzheimer's disease, as it shows neuroprotection in several experimental (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049763 Tue, 19 Jul 2011 23:00:00 +0100 5049763 Gut feelings: the emerging biology of gut–brain communication http://www.medworm.com/index.php?rid=5049777&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FwLv1sh9NZSA%2Fnrn3071 Nature Reviews Neuroscience 12, 453 (2011). doi:10.1038/nrn3071 Author: Emeran A. Mayer The concept that the gut and the brain are closely connected, and that this interaction plays an important part not only in gastrointestinal function but also in certain feeling states and in intuitive decision making, is deeply rooted in our language. Recent neurobiological insights into (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049777 Tue, 12 Jul 2011 23:00:00 +0100 5049777 Psychiatric disorders: The dark side of depression http://www.medworm.com/index.php?rid=5049775&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FaM9TVZ_XmTk%2Fnrn3072 Nature Reviews Neuroscience 12, 435 (2011). doi:10.1038/nrn3072 Author: Leonie Welberg Immune factors mediate the effect of circadian disruption on depression-like behaviour (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049775 Tue, 12 Jul 2011 23:00:00 +0100 5049775 Behavioural neuroscience: Fly fisticuffs http://www.medworm.com/index.php?rid=5049774&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FMVO647-vkKU%2Fnrn3078 Nature Reviews Neuroscience 12, 434 (2011). doi:10.1038/nrn3078 Author: Sian Lewis Loneliness increases aggressiveness, even in flies (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049774 Tue, 12 Jul 2011 23:00:00 +0100 5049774 Stem cells: Experiences direct fate http://www.medworm.com/index.php?rid=5049769&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FtsmSFQIOc8c%2Fnrn3077 Nature Reviews Neuroscience 12, 432 (2011). doi:10.1038/nrn3077 Author: Darran Yates Adult hippocampal neural stem cells can give rise to persisting populations of stem cells and neurons, with cell fate being affected by an animal's experiences. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049769 Tue, 12 Jul 2011 23:00:00 +0100 5049769 Using theoretical models to analyse neural development http://www.medworm.com/index.php?rid=5049782&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F6euvZV1adDE%2Fnrn3076 Nature Reviews Neuroscience 12, 484 (2011). doi:10.1038/nrn3076 Author: Arjen van Ooyen Nature Reviews Neuroscience12, 311–326 (2011)On page 326 of this article, the acknowledgements section should have included the following information: The work was supported by the Self-Constructing Computing Systems project (216593) of the Seventh Framework Programme of the (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049782 Tue, 05 Jul 2011 23:00:00 +0100 5049782 Neural mechanisms of the cognitive model of depression http://www.medworm.com/index.php?rid=5049778&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F1K3kW3xxP2g%2Fnrn3027 Authors: Seth G. Disner, Christopher G. Beevers, Emily A. P. Haigh & Aaron T. Beck In the 40 years since Aaron Beck first proposed his cognitive model of depression, the elements of this model — biased attention, biased processing, biased thoughts and rumination, biased memory, and dysfunctional attitudes and schemas — have been consistently linked with the onset and maintenance (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049778 Tue, 05 Jul 2011 23:00:00 +0100 5049778 Circadian rhythms: Calcium sets the tempo http://www.medworm.com/index.php?rid=5049772&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FmjfVzZMDs34%2Fnrn3073 Nature Reviews Neuroscience 12, 434 (2011). doi:10.1038/nrn3073 Author: Katherine Whalley Calcium signalling mediates circadian regulation of extracellular ATP accumulation by astrocytes. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049772 Tue, 28 Jun 2011 23:00:00 +0100 5049772 Learning and memory: Flies know their way http://www.medworm.com/index.php?rid=5049770&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FtAqlYp_60k8%2Fnrn3074 Nature Reviews Neuroscience 12, 432 (2011). doi:10.1038/nrn3074 Author: Monica Hoyos Flight Flies use visual cues to guide their navigation and require neurons in the ellipsoid body to do so. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049770 Tue, 28 Jun 2011 23:00:00 +0100 5049770 Linking lipids to Alzheimer's disease: cholesterol and beyond http://www.medworm.com/index.php?rid=5049781&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FOuGu5B4ybIY%2Fnrn3075 Nature Reviews Neuroscience 12, 484 (2011). doi:10.1038/nrn3075 Author: Gilbert Di Paolo & Tae-Wan Kim Nature Reviews Neuroscience12, 284–296 (2011)On page 284 of this article, in the author addresses section, the e-mail address for Gilbert Di Paolo was incorrect. The correct e-mail address is: gil.dipaolo@columbia.edu (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049781 Wed, 22 Jun 2011 23:00:00 +0100 5049781 Sensory systems: A promising line of defence http://www.medworm.com/index.php?rid=5049768&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FRS0gGX56WVc%2Fnrn3070 Nature Reviews Neuroscience 12, 431 (2011). doi:10.1038/nrn3070 Author: Monica Hoyos Flight Odorants that cause prolonged activation of CO2-sensing neurons in mosquitoes interfere with their host-seeking behaviour, and might lead to the development of a new class of insect repellents. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049768 Tue, 21 Jun 2011 23:00:00 +0100 5049768 Pain: Blocking painful interactions http://www.medworm.com/index.php?rid=5049767&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FeNgUWMkzwlo%2Fnrn3069 Nature Reviews Neuroscience 12, 431 (2011). doi:10.1038/nrn3069 Author: Katherine Whalley Blocking interactions between CRMP2 and the calcium channel CaV2.2 suppresses imflammatory and neuropathic pain. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049767 Tue, 21 Jun 2011 23:00:00 +0100 5049767 The benefits of noise in neural systems: bridging theory and experiment http://www.medworm.com/index.php?rid=4952533&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F5EnBGf-ro-g%2Fnrn3061 Authors: Mark D. McDonnell & Lawrence M. Ward Although typically assumed to degrade performance, random fluctuations, or noise, can sometimes improve information processing in non-linear systems. One such form of 'stochastic facilitation', stochastic resonance, has been observed to enhance processing both in theoretical models of neural systems and in experimental neuroscience. However, the (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952533 Sun, 19 Jun 2011 23:00:00 +0100 4952533 From the stochasticity of molecular processes to the variability of synaptic transmission http://www.medworm.com/index.php?rid=4952530&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FxDpHimPDfjY%2Fnrn3025 Authors: Claire Ribrault, Ken Sekimoto & Antoine Triller The variability of the postsynaptic response following a single action potential arises from two sources: the neurotransmitter release is probabilistic, and the postsynaptic response to neurotransmitter release has variable timing and amplitude. At individual synapses, the number of molecules of a given type that are (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952530 Sun, 19 Jun 2011 23:00:00 +0100 4952530 In Brief http://www.medworm.com/index.php?rid=4952529&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FoBXlI1Ao85A%2Fnrn3065 Nature Reviews Neuroscience 12, 373 (2011). doi:10.1038/nrn3065 Stem cellsSpecification of transplantable astroglial subtypes from human pluripotent stem cellsKrencik, R.et al. Nature Biotechnol.20 May 2011 (doi:10.1038/nbt.1877)The mechanisms underlying regional astroglial differentiation during development are not well understood but are thought to occur through (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952529 Sun, 19 Jun 2011 23:00:00 +0100 4952529 From the editors http://www.medworm.com/index.php?rid=4952520&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F5UXn4K91gkQ%2Fnrn3067 Nature Reviews Neuroscience 12, 367 (2011). doi:10.1038/nrn3067 Stochasticity is the theme for two articles in this issue. On page 375, Triller and colleagues discuss stochastic influences on synaptic transmission. They explain that because synaptic transmission involves small quantities of different molecules, the stochastic aspects of these molecules' behaviour might contribute to (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952520 Sun, 19 Jun 2011 23:00:00 +0100 4952520 Emotion and the brain: multiple roads are better than one http://www.medworm.com/index.php?rid=4952535&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FZFPLtPyKLf4%2Fnrn2920-c2 Authors: Luiz Pessoa & Ralph Adolphs We have recently provided a critical evaluation of the idea that a subcortical pathway through the superior colliculus and pulvinar to the amygdala has a prominent and privileged role in processing affective visual stimuli (Emotion processing and the amygdala: from a 'low road' to 'many (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952535 Tue, 14 Jun 2011 23:00:00 +0100 4952535 Emotion in the brain: of low roads, high roads and roads less travelled http://www.medworm.com/index.php?rid=4952534&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FNMluk8pHUKU%2Fnrn2920-c1 Authors: Beatrice de Gelder, Jack van Honk & Marco Tamietto Traditionally, the cerebral cortex is considered the dominant player in understanding human brain functions, with subcortical structures relegated to a subservient role. In a recent Perspective article, Pessoa and Adolphs partly return to this traditional corticocentric view in the field of emotion processing (Emotion processing (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952534 Tue, 14 Jun 2011 23:00:00 +0100 4952534 Repertoire of microglial and macrophage responses after spinal cord injury http://www.medworm.com/index.php?rid=4952531&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FYe40u4iR5w4%2Fnrn3053 Authors: Samuel David & Antje Kroner Macrophages from the peripheral circulation and those derived from resident microglia are among the main effector cells of the inflammatory response that follows spinal cord trauma. There has been considerable debate in the field as to whether the inflammatory response is good or bad for (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952531 Tue, 14 Jun 2011 23:00:00 +0100 4952531 Synaptic plasticity: Finely tuning caspase function http://www.medworm.com/index.php?rid=4952524&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FGqCiVtIHUvk%2Fnrn3066 Nature Reviews Neuroscience 12, 371 (2011). doi:10.1038/nrn3066 Author: Darran Yates Variation in BAD–BAX signalling alters the level of caspase 3 activity and determines the function of this protease. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952524 Tue, 14 Jun 2011 23:00:00 +0100 4952524 In Brief http://www.medworm.com/index.php?rid=4952523&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F6hlZ79MVzbY%2Fnrn3064 Nature Reviews Neuroscience 12, 370 (2011). doi:10.1038/nrn3064 MetabolismBrain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinedionesLu, M.et al. Nature Med.17, 618–622 (2011)A role for central nervous system PPAR-γ in the regulation of energy balanceRyan (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952523 Tue, 14 Jun 2011 23:00:00 +0100 4952523 Autism: Converging pathways http://www.medworm.com/index.php?rid=4952526&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F0Yi1Ihlejy8%2Fnrn3062 Nature Reviews Neuroscience 12, 372 (2011). doi:10.1038/nrn3062 Author: Katherine Whalley Transcriptome analysis reveals a common molecular pathway in autism. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952526 Tue, 07 Jun 2011 23:00:00 +0100 4952526 Evolution: Three major steps to a mammalian brain http://www.medworm.com/index.php?rid=4952525&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FhO70pF3ZOVw%2Fnrn3063 Nature Reviews Neuroscience 12, 371 (2011). doi:10.1038/nrn3063 Author: Monica Hoyos Flight High-resolution X-ray computed tomography sheds new light on the early evolution of mammalian brains. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952525 Tue, 07 Jun 2011 23:00:00 +0100 4952525 Differentiating the rapid actions of cocaine http://www.medworm.com/index.php?rid=5049779&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FePTyaEzdz6k%2Fnrn3043 Authors: Roy A. Wise & Eugene A. Kiyatkin The subjective effects of intravenous cocaine are felt almost immediately, and this immediacy plays an important part in the drug's rewarding impact. The primary rewarding effect of cocaine involves blockade of dopamine reuptake; however, the onset of this action is too late to account for (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=5049779 Wed, 01 Jun 2011 23:00:00 +0100 5049779 Cognitive and neurobiological mechanisms of alcohol-related aggression http://www.medworm.com/index.php?rid=4952532&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FVpwG9gwho9k%2Fnrn3042 Authors: Adrienne J. Heinz, Anne Beck, Andreas Meyer-Lindenberg, Philipp Sterzer & Andreas Heinz Alcohol-related violence is a serious and common social problem. Moreover, violent behaviour is much more common in alcohol-dependent individuals. Animal experiments and human studies have provided insights into the acute effect of alcohol on aggressive behaviour and into common factors underlying acute and chronic alcohol (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952532 Wed, 01 Jun 2011 23:00:00 +0100 4952532 Neurodegenerative disease: Directing amyloid-β deposition http://www.medworm.com/index.php?rid=4952528&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FARdhVCjDlTY%2Fnrn3059 Nature Reviews Neuroscience 12, 372 (2011). doi:10.1038/nrn3059 Author: Darran Yates Neuronal activity seems to regulate the brain area-specific distribution of amyloid-β pathology in a mouse model of Alzheimer's disease. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952528 Wed, 01 Jun 2011 23:00:00 +0100 4952528 Auditory processing: Sounding out consciousness http://www.medworm.com/index.php?rid=4952521&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FvTlbimY_RN4%2Fnrn3058 Nature Reviews Neuroscience 12, 369 (2011). doi:10.1038/nrn3058 Author: Leonie Welberg Conscious perception of auditory stimuli requires top-down, feedback connectivity from frontal to temporal cortices, which is absent in the vegetative state and present in the minimally conscious state. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952521 Wed, 01 Jun 2011 23:00:00 +0100 4952521 Memory: The foundations of accurate recall http://www.medworm.com/index.php?rid=4952527&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FeP3Vv-IANJw%2Fnrn3055 Nature Reviews Neuroscience 12, 372 (2011). doi:10.1038/nrn3055 Author: Monica Hoyos Flight Learning-related structural plasticity contributes to memory encoding and recall by increasing feedforward inhibition. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952527 Tue, 24 May 2011 23:00:00 +0100 4952527 Spatial coding: Oscillations maintain grid position http://www.medworm.com/index.php?rid=4952522&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F5H-jvqU1uM4%2Fnrn3056 Nature Reviews Neuroscience 12, 370 (2011). doi:10.1038/nrn3056 Author: Katherine Whalley Two papers show that theta oscillations are required for grid cell function. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952522 Tue, 24 May 2011 23:00:00 +0100 4952522 Molecular neuroscience: Synaptotagmin 10-mediated release http://www.medworm.com/index.php?rid=4847687&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FcLrxFwbRcps%2Fnrn3051 Nature Reviews Neuroscience 12, 307 (2011). doi:10.1038/nrn3051 Author: Darran Yates Synaptotagmin 10 regulates calcium-dependent insulin-like growth factor 1 exocytosis in olfactory bulb neurons. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4847687 Sat, 21 May 2011 05:40:15 +0100 4847687 Neurotransmitter receptors: Negotiating the cytoskeletal tracks in neurons http://www.medworm.com/index.php?rid=4847686&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FVwpRmV-Ktvw%2Fnrn3050 Nature Reviews Neuroscience 12, 307 (2011). doi:10.1038/nrn3050 Author: Darran Yates Muskelin regulates the transport of GABA type A receptors (GABAARs) along actin filaments and microtubules in neurons. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4847686 Sat, 21 May 2011 05:40:15 +0100 4847686 In Brief http://www.medworm.com/index.php?rid=4847691&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FrkzRFYatCQ8%2Fnrn3052 Nature Reviews Neuroscience 12, 309 (2011). doi:10.1038/nrn3052 SleepNotch signaling modulates sleep homeostasis and learning after sleep deprivation in DrosophilaSeugnet, L.et al. Curr. Biol.21, 1–6 (2011)The authors showed that sleep deprivation impaired learning in mutant flies with loss of (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4847691 Thu, 19 May 2011 23:00:00 +0100 4847691 From the editors http://www.medworm.com/index.php?rid=4847682&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2Fvpy5cze01QE%2Fnrn3049 Nature Reviews Neuroscience 12, 303 (2011). doi:10.1038/nrn3049 It is well-established that neurons can encode and transmit information by altering their firing rate; however, the idea that the spatiotemporal pattern of firing is also important for information processing is growing in popularity. In a Review on page 327, De Zeeuw and colleagues (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4847682 Thu, 19 May 2011 23:00:00 +0100 4847682 From glutamate co-release to vesicular synergy: vesicular glutamate transporters http://www.medworm.com/index.php?rid=4952536&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F7jur3Q69AFo%2Fnrn3054 Nature Reviews Neuroscience 12, 425 (2011). doi:10.1038/nrn3054 Author: Salah El Mestikawy, Åsa Wallén-Mackenzie, Guillaume M. Fortin, Laurent Descarries & Louis-Eric Trudeau Nature Reviews Neuroscience12, 204–216 (2011)On page 209 of the above article, 'Nucleus accumbensb33-35, neostriatum33-35' should be listed under 'Terminals' not 'Cell bodies'. The online version of the article has been corrected accordingly. (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4952536 Wed, 18 May 2011 23:00:00 +0100 4952536 Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates http://www.medworm.com/index.php?rid=4847695&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2FT0B3SttVCaE%2Fnrn3039 Authors: Timothy J. Collier, Nicholas M. Kanaan & Jeffrey H. Kordower Ageing is the greatest risk factor for the development of Parkinson's disease. However, the current dogma holds that cellular mechanisms that are associated with ageing of midbrain dopamine neurons and those that are related to dopamine neuron degeneration in Parkinson's disease are unrelated. We propose, (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4847695 Tue, 17 May 2011 23:00:00 +0100 4847695 Microbes' roadmap to neurons http://www.medworm.com/index.php?rid=4847694&cid=s_32261_168_f&fid=32261&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnrn%2Frss%2Fcurrent%2F%7E3%2F0lH9921qP8Y%2Fnrn3029 Nature Reviews Neuroscience 12, 345 (2011). doi:10.1038/nrn3029 Author: Krister Kristensson The nervous system is protected by barriers that restrict the invasion of pathogens. Nevertheless, mechanisms have evolved by which microbes can pass these barriers, enter and exit neurons and target various regions of the nervous system. In the brain, immune responses to pathogens are generally (Source: Nature Reviews Neuroscience) Nature Reviews Neuroscience journals http://www.medworm.com/rss/comments.php?id=4847694 Tue, 17 May 2011 23:00:00 +0100 4847694