Nature Structural and Molecular Biology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nature Structural and Molecular Biology' source. Thu, 09 Feb 2012 16:56:52 +0100 A single amino acid residue can determine the sensitivity of SERCAs to artemisinins http://www.medworm.com/index.php?rid=5656475&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FKorOZ2aQUwM%2Fnsmb0212-264 Nature Structural & Molecular Biology 19, 264 (2012). doi:10.1038/nsmb0212-264 Author: Anne-Catrin Uhlemann, Angus Cameron, Ursula Eckstein-Ludwig, Jorge Fischbarg, Pavel Iserovich, Felipe A Zuniga, Malcolm East, Anthony Lee, Leo Brady, Richard K Haynes & Sanjeev Krishna (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656475 Fri, 03 Feb 2012 21:28:24 +0100 5656475 Intrinsic regulation http://www.medworm.com/index.php?rid=5656456&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FIHafhjDYxtg%2Fnsmb.2247 Nature Structural & Molecular Biology 19, 135 (2012). doi:10.1038/nsmb.2247 Author: Michelle Montoya (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656456 Fri, 03 Feb 2012 05:00:00 +0100 5656456 Tumor-suppressive Smurf http://www.medworm.com/index.php?rid=5656455&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FeoLexKNv7ZY%2Fnsmb.2248 Nature Structural & Molecular Biology 19, 135 (2012). doi:10.1038/nsmb.2248 Author: Steve Mason (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656455 Fri, 03 Feb 2012 05:00:00 +0100 5656455 Adaptation by RNA editing http://www.medworm.com/index.php?rid=5656454&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fyp9zUu6ynq4%2Fnsmb.2246 Nature Structural & Molecular Biology 19, 135 (2012). doi:10.1038/nsmb.2246 Author: Arianne Heinrichs (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656454 Fri, 03 Feb 2012 05:00:00 +0100 5656454 Swift, strandwise translocation http://www.medworm.com/index.php?rid=5656453&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F--VCoykzFwY%2Fnsmb.2249 Nature Structural & Molecular Biology 19, 135 (2012). doi:10.1038/nsmb.2249 Author: Angela K. Eggleston (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656453 Fri, 03 Feb 2012 05:00:00 +0100 5656453 A team effort blocks the ribosome in its tracks http://www.medworm.com/index.php?rid=5656452&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FiHiaJYaUTyU%2Fnsmb.2236 Nature Structural & Molecular Biology 19, 133 (2012). doi:10.1038/nsmb.2236 Author: Amy E Pasquinelli A complex of PUF (named after founding members Pumilio and Fem-3 binding factor) and Argonaute proteins can stall translation elongation on bound mRNAs by interacting with eEF1A and inhibiting its GTPase activity. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656452 Fri, 03 Feb 2012 05:00:00 +0100 5656452 Cbl exposes its RING finger http://www.medworm.com/index.php?rid=5656451&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FY31PUnnOano%2Fnsmb.2241 Authors: Stephen C Kales, Philip E Ryan & Stanley Lipkowitz The Cbl family of RING finger ubiquitin ligases regulates signaling in many systems. Two new studies provide a structural basis for how phosphorylation of a specific tyrosine in the Cbl proteins enhances their ubiquitin ligase activity, giving insight into how ubiquitination by Cbl proteins is restricted to specific substrates. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656451 Fri, 03 Feb 2012 05:00:00 +0100 5656451 It takes two to transport, or is it one? http://www.medworm.com/index.php?rid=5656450&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FANqbXkhAq_I%2Fnsmb.2239 Authors: Hyun-Ho Lim & Christopher Miller The proteins that 'pump' neurotransmitters into neurons, clearing the synapse after a nerve impulse, are central players in coherent brain function and are targets of many psychotropic drugs. Two groups now endeavor to resolve a fundamental controversy about how these proteins work. The results shed new light on the controversy but do not end it. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656450 Fri, 03 Feb 2012 05:00:00 +0100 5656450 HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism http://www.medworm.com/index.php?rid=5656473&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fff7XM7sTHcc%2Fnsmb.2223 Authors: Kalyan Das, Sergio E Martinez, Joseph D Bauman & Eddy Arnold (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656473 Sun, 22 Jan 2012 05:00:00 +0100 5656473 Crystal structure of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus http://www.medworm.com/index.php?rid=5656471&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FrHooBQ6HP10%2Fnsmb.2213 Authors: Yushi Matsumoto, Takehiko Tosha, Andrei V Pisliakov, Tomoya Hino, Hiroshi Sugimoto, Shingo Nagano, Yuji Sugita & Yoshitsugu Shiro (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656471 Sun, 22 Jan 2012 05:00:00 +0100 5656471 The E3 ligase RNF8 regulates KU80 removal and NHEJ repair http://www.medworm.com/index.php?rid=5656466&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F7KlyqBTlf5w%2Fnsmb.2211 Authors: Lin Feng & Junjie Chen (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656466 Sun, 22 Jan 2012 05:00:00 +0100 5656466 Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl http://www.medworm.com/index.php?rid=5656464&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FYXpPF1g3wzY%2Fnsmb.2231 Authors: Hao Dou, Lori Buetow, Andreas Hock, Gary J Sibbet, Karen H Vousden & Danny T Huang (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656464 Sun, 22 Jan 2012 05:00:00 +0100 5656464 Regulation of Rev1 by the Fanconi anemia core complex http://www.medworm.com/index.php?rid=5656461&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FVQzZRVb1Un8%2Fnsmb.2222 Authors: Hyungjin Kim, Kailin Yang, Donniphat Dejsuphong & Alan D D'Andrea (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656461 Sun, 22 Jan 2012 05:00:00 +0100 5656461 Molecular basis for RNA polymerization by Qβ replicase http://www.medworm.com/index.php?rid=5656470&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FPPrlA93ROXg%2Fnsmb.2204 Authors: Daijiro Takeshita & Kozo Tomita (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656470 Sun, 15 Jan 2012 05:00:00 +0100 5656470 The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation http://www.medworm.com/index.php?rid=5656469&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FmaRwIhVsT2s%2Fnsmb.2207 Authors: Olga Anczuków, Avi Z Rosenberg, Martin Akerman, Shipra Das, Lixing Zhan, Rotem Karni, Senthil K Muthuswamy & Adrian R Krainer (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656469 Sun, 15 Jan 2012 05:00:00 +0100 5656469 Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context http://www.medworm.com/index.php?rid=5656468&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FUpyFeGeJ3Iw%2Fnsmb.2215 Authors: Hui Wang, Johannes Elferich & Eric Gouaux (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656468 Sun, 15 Jan 2012 05:00:00 +0100 5656468 Experimental conditions can obscure the second high-affinity site in LeuT http://www.medworm.com/index.php?rid=5656467&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fd0seerEToOM%2Fnsmb.2197 Authors: Matthias Quick, Lei Shi, Britta Zehnpfennig, Harel Weinstein & Jonathan A Javitch (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656467 Sun, 15 Jan 2012 05:00:00 +0100 5656467 Phosphorylation-dependent activity of the deubiquitinase DUBA http://www.medworm.com/index.php?rid=5656462&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FnjzCxnqkXyE%2Fnsmb.2206 Authors: Oscar W Huang, Xiaolei Ma, JianPing Yin, Jeremy Flinders, Till Maurer, Nobuhiko Kayagaki, Qui Phung, Ivan Bosanac, David Arnott, Vishva M Dixit, Sarah G Hymowitz, Melissa A Starovasnik & Andrea G Cochran (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656462 Sun, 15 Jan 2012 05:00:00 +0100 5656462 Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ http://www.medworm.com/index.php?rid=5656459&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FMMrSGhawqKg%2Fnsmb.2210 Authors: Hélène Malet, Flavia Canellas, Justyna Sawa, Jun Yan, Konstantinos Thalassinos, Michael Ehrmann, Tim Clausen & Helen R Saibil (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656459 Sun, 15 Jan 2012 05:00:00 +0100 5656459 The N domain of Argonaute drives duplex unwinding during RISC assembly http://www.medworm.com/index.php?rid=5656458&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FZjBlgMLYOAo%2Fnsmb.2232 Authors: Pieter Bas Kwak & Yukihide Tomari (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656458 Tue, 10 Jan 2012 05:00:00 +0100 5656458 Chromodomains read the arginine code of post-translational targeting http://www.medworm.com/index.php?rid=5656474&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fu0AaW24x3ZE%2Fnsmb.2196 We report the crystal structure of the chloroplast signal recognition particle (cpSRP) core from Arabidopsis thaliana, with the cpSRP54 tail comprising an arginine-rich motif bound to the second chromodomain of cpSRP43. A twinned aromatic cage reads out two neighboring nonmethylated arginines and adapts chromodomains to a non-nuclear function in post-translational targeting. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656474 Sun, 08 Jan 2012 05:00:00 +0100 5656474 Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2 http://www.medworm.com/index.php?rid=5656472&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FvbhLBAB_OPY%2Fnsmb.2212 Authors: Jeffrey Buis, Trina Stoneham, Elizabeth Spehalski & David O Ferguson (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656472 Sun, 08 Jan 2012 05:00:00 +0100 5656472 Dynein achieves processive motion using both stochastic and coordinated stepping http://www.medworm.com/index.php?rid=5656465&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FhVGCiLkg8oM%2Fnsmb.2205 Authors: Weihong Qiu, Nathan D Derr, Brian S Goodman, Elizabeth Villa, David Wu, William Shih & Samara L Reck-Peterson (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656465 Sun, 08 Jan 2012 05:00:00 +0100 5656465 A conserved PUF–Ago–eEF1A complex attenuates translation elongation http://www.medworm.com/index.php?rid=5656463&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FKyAuBTK4kMs%2Fnsmb.2214 Authors: Kyle Friend, Zachary T Campbell, Amy Cooke, Peggy Kroll-Conner, Marvin P Wickens & Judith Kimble (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656463 Sun, 08 Jan 2012 05:00:00 +0100 5656463 Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating http://www.medworm.com/index.php?rid=5656460&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F_jgF3V3t3BQ%2Fnsmb.2208 Authors: Vassiliy N Bavro, Rita De Zorzi, Matthias R Schmidt, João R C Muniz, Lejla Zubcevic, Mark S P Sansom, Catherine Vénien-Bryan & Stephen J Tucker (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656460 Sun, 08 Jan 2012 05:00:00 +0100 5656460 Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance http://www.medworm.com/index.php?rid=5656457&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FUSaFVSWEiLk%2Fnsmb.2209 Authors: Valentina Migliori, Julius Müller, Sameer Phalke, Diana Low, Marco Bezzi, Wei Chuen Mok, Sanjeeb Kumar Sahu, Jayantha Gunaratne, Paola Capasso, Christian Bassi, Valentina Cecatiello, Ario De Marco, Walter Blackstock, Vladimir Kuznetsov, Bruno Amati, Marina Mapelli & Ernesto Guccione (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5656457 Sun, 08 Jan 2012 05:00:00 +0100 5656457 New approaches for dissecting protease functions to improve probe development and drug discovery http://www.medworm.com/index.php?rid=5568822&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F59_ZEBqOdW8%2Fnsmb.2203 Authors: Edgar Deu, Martijn Verdoes & Matthew Bogyo (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568822 Thu, 05 Jan 2012 05:00:00 +0100 5568822 Rli1 does the splits http://www.medworm.com/index.php?rid=5568821&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FloBqsm38k6E%2Fnsmb.2229 Nature Structural & Molecular Biology 19, 8 (2012). doi:10.1038/nsmb.2229 Author: Angela K. Eggleston (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568821 Thu, 05 Jan 2012 05:00:00 +0100 5568821 Stalled out http://www.medworm.com/index.php?rid=5568820&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FSBSorWYwyNc%2Fnsmb.2228 Nature Structural & Molecular Biology 19, 8 (2012). doi:10.1038/nsmb.2228 Author: Steve Mason (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568820 Thu, 05 Jan 2012 05:00:00 +0100 5568820 Structural basis of silencing http://www.medworm.com/index.php?rid=5568819&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FPtde2UZJXMQ%2Fnsmb.2227 Nature Structural & Molecular Biology 19, 8 (2012). doi:10.1038/nsmb.2227 Author: Arianne Heinrichs (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568819 Thu, 05 Jan 2012 05:00:00 +0100 5568819 Methylating fingers http://www.medworm.com/index.php?rid=5568818&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FD1mFgGfGyT4%2Fnsmb.2226 Nature Structural & Molecular Biology 19, 8 (2012). doi:10.1038/nsmb.2226 Author: Michelle Montoya (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568818 Thu, 05 Jan 2012 05:00:00 +0100 5568818 Thresholds of replication stress signaling in cancer development and treatment http://www.medworm.com/index.php?rid=5568817&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FlT4duL-T4hU%2Fnsmb.2220 Authors: Jiri Bartek, Martin Mistrik & Jirina Bartkova Oncogene-induced replication stress and DNA damage are among the hallmarks of cancer. A recent study explores how different levels of replication stress affect animal development and tumorigenesis, and how targeting of the replication stress–signaling pathway of ATR and Chk1 kinases can be exploited for selective killing of cancer cells. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568817 Thu, 05 Jan 2012 05:00:00 +0100 5568817 Claims and counterclaims of X-chromosome compensation http://www.medworm.com/index.php?rid=5568816&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F6sIxh2DXf7M%2Fnsmb.2218 Nature Structural & Molecular Biology 19, 3 (2012). doi:10.1038/nsmb.2218 Author: James A Birchler Is there upregulation of the single active X chromosome in mammals or not? Recent studies take different points of view. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568816 Thu, 05 Jan 2012 05:00:00 +0100 5568816 Finding the missing links in EGFR http://www.medworm.com/index.php?rid=5568815&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F9szMCoiJZMY%2Fnsmb.2221 Authors: Nicholas J Bessman & Mark A Lemmon Structural studies of the epidermal growth factor receptor (EGFR) have advanced greatly in recent years, but they have used a 'divide-and-conquer' approach for independent study of the intracellular and extracellular regions. Several recent papers provide important new perspectives on 'undivided' EGFR and describe the initial steps in reconstructing signaling behavior of the intact receptor. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568815 Thu, 05 Jan 2012 05:00:00 +0100 5568815 A metal switch for controlling the activity of molecular motor proteins http://www.medworm.com/index.php?rid=5568838&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FjZcmKKL204M%2Fnsmb.2190 Authors: Jared C Cochran, Yu Cheng Zhao, Dean E Wilcox & F Jon Kull (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568838 Sun, 25 Dec 2011 05:00:00 +0100 5568838 A cis-antisense RNA acts in trans in Staphylococcus aureus to control translation of a human cytolytic peptide http://www.medworm.com/index.php?rid=5568835&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FIAHVR1G3ieM%2Fnsmb.2193 Authors: Nour Sayed, Ambre Jousselin & Brice Felden (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568835 Sun, 25 Dec 2011 05:00:00 +0100 5568835 Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi http://www.medworm.com/index.php?rid=5568833&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FIk8EIPfUKWg%2Fnsmb.2186 Authors: Caroline Thivierge, Neetha Makil, Mathieu Flamand, Jessica J Vasale, Craig C Mello, James Wohlschlegel, Darryl Conte & Thomas F Duchaine (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568833 Sun, 18 Dec 2011 05:00:00 +0100 5568833 The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide http://www.medworm.com/index.php?rid=5568831&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FEJ2aRDuIatU%2Fnsmb.2191 Authors: Priyanka Narayan, Angel Orte, Richard W Clarke, Benedetta Bolognesi, Sharon Hook, Kristina A Ganzinger, Sarah Meehan, Mark R Wilson, Christopher M Dobson & David Klenerman (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568831 Sun, 18 Dec 2011 05:00:00 +0100 5568831 Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops http://www.medworm.com/index.php?rid=5568830&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FQjDVSHcfn_Q%2Fnsmb.2175 Authors: Shikha Gupta, Martin Gellert & Wei Yang (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568830 Sun, 18 Dec 2011 05:00:00 +0100 5568830 Signal-dependent dynamics of transcription factor translocation controls gene expression http://www.medworm.com/index.php?rid=5568825&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FSYjrH8qPAQQ%2Fnsmb.2192 Authors: Nan Hao & Erin K O'Shea (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568825 Sun, 18 Dec 2011 05:00:00 +0100 5568825 Fluorescent fusion protein knockout mediated by anti-GFP nanobody http://www.medworm.com/index.php?rid=5568837&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FJ3GgoF8cLNE%2Fnsmb.2180 Authors: Emmanuel Caussinus, Oguz Kanca & Markus Affolter (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568837 Sun, 11 Dec 2011 05:00:00 +0100 5568837 Single-molecule studies reveal the function of a third polymerase in the replisome http://www.medworm.com/index.php?rid=5568836&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FcC3A7sIEjuc%2Fnsmb.2179 Authors: Roxana E Georgescu, Isabel Kurth & Mike E O'Donnell The Escherichia coli replisome contains three polymerases, one more than necessary to duplicate the two parental strands. Using single-molecule studies, we reveal two advantages conferred by the third polymerase. First, dipolymerase replisomes are inefficient at synthesizing lagging strands, leaving single-strand gaps, whereas tripolymerase replisomes fill strands almost to completion. Second, tripolymerase replisomes are much more processive than dipolymerase replisomes. These features account for the unexpected three-polymerase-structure of bacterial replisomes. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568836 Sun, 11 Dec 2011 05:00:00 +0100 5568836 Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28 http://www.medworm.com/index.php?rid=5568832&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FhUGDM1XFBkQ%2Fnsmb.2202 Authors: Fionna E Loughlin, Luca F R Gebert, Harry Towbin, Andreas Brunschweiger, Jonathan Hall & Frédéric H-T Allain (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568832 Sun, 11 Dec 2011 05:00:00 +0100 5568832 An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains http://www.medworm.com/index.php?rid=5568829&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FPsp3UJII2_A%2Fnsmb.2169 Authors: Julien D F Licchesi, Juliusz Mieszczanek, Tycho E T Mevissen, Trevor J Rutherford, Masato Akutsu, Satpal Virdee, Farid El Oualid, Jason W Chin, Huib Ovaa, Mariann Bienz & David Komander (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568829 Sun, 11 Dec 2011 05:00:00 +0100 5568829 Intrinsic tethering activity of endosomal Rab proteins http://www.medworm.com/index.php?rid=5568826&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FZQ5cT4pWW-k%2Fnsmb.2162 Authors: Sheng-Ying Lo, Christopher L Brett, Rachael L Plemel, Marissa Vignali, Stanley Fields, Tamir Gonen & Alexey J Merz (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568826 Sun, 11 Dec 2011 05:00:00 +0100 5568826 If yeast had brains http://www.medworm.com/index.php?rid=5483064&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fl8yaKn55SRE%2Fnsmb.2201 Nature Structural & Molecular Biology 18, 1322 (2011). doi:10.1038/nsmb.2201 Author: Inês Chen (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483064 Mon, 05 Dec 2011 05:00:00 +0100 5483064 Signaling for purines http://www.medworm.com/index.php?rid=5483063&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FPEfzcukrByA%2Fnsmb.2200 Nature Structural & Molecular Biology 18, 1322 (2011). doi:10.1038/nsmb.2200 Author: Steve Mason (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483063 Mon, 05 Dec 2011 05:00:00 +0100 5483063 Itch (and Cyld) stops inflammation http://www.medworm.com/index.php?rid=5483062&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F_AJaMfrJKag%2Fnsmb.2199 Nature Structural & Molecular Biology 18, 1322 (2011). doi:10.1038/nsmb.2199 Author: Michelle Montoya (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483062 Mon, 05 Dec 2011 05:00:00 +0100 5483062 Nuclear RNAi in fly http://www.medworm.com/index.php?rid=5483061&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FuFWOf92eueM%2Fnsmb.2198 Nature Structural & Molecular Biology 18, 1322 (2011). doi:10.1038/nsmb.2198 Author: Arianne Heinrichs (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483061 Mon, 05 Dec 2011 05:00:00 +0100 5483061 Prospects for an HIV vaccine: leading B cells down the right path http://www.medworm.com/index.php?rid=5483060&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FK7K-MJHI_xM%2Fnsmb.2194 Authors: Susan Moir, Angela Malaspina & Anthony S Fauci Until recently, few potent and broadly neutralizing HIV-specific antibodies had been identified, but recent findings have inspired optimism that an effective HIV vaccine can finally be developed. Here we review these studies, which used state-of-the-art high-throughput techniques to collectively describe hundreds of new potent and broad HIV-neutralizing antibodies isolated from HIV-infected individuals. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483060 Mon, 05 Dec 2011 05:00:00 +0100 5483060 Celebrating structural biology http://www.medworm.com/index.php?rid=5483059&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Ff3GRc7CKJ88%2Fnsmb1211-1304 Nature Structural & Molecular Biology 18, 1304 (2011). doi:10.1038/nsmb1211-1304 The editors of Nature Structural & Molecular Biology have assembled a special Essay Collection, coinciding with the 40th anniversary of the Protein Data Bank, to reflect on the history and future of structural biology. These personal accounts collectively tell the history of structural biology and provide perspectives on the direction of the field and challenges that it faces. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483059 Mon, 05 Dec 2011 05:00:00 +0100 5483059 Marking the occasion http://www.medworm.com/index.php?rid=5483058&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FPg9t06Kr6-0%2Fnsmb1211-1303 Nature Structural & Molecular Biology 18, 1303 (2011). doi:10.1038/nsmb1211-1303 Every issue of NSMB is special to us, but this one marks the end of 2011 with two features that deserve extra attention: a Commentary and an Essay Collection. These pieces and the research articles presented in this issue illustrate what NSMB is all about. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483058 Mon, 05 Dec 2011 05:00:00 +0100 5483058 Mispaired rNMPs in DNA are mutagenic and are targets of mismatch repair and RNases H http://www.medworm.com/index.php?rid=5568834&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FIwu3_R_Hd74%2Fnsmb.2176 Authors: Ying Shen, Kyung Duk Koh, Bernard Weiss & Francesca Storici (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568834 Sun, 04 Dec 2011 05:00:00 +0100 5568834 X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription http://www.medworm.com/index.php?rid=5568828&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FKH7RBV3yYew%2Fnsmb.2195 Authors: Eda Yildirim, Ruslan I Sadreyev, Stefan F Pinter & Jeannie T Lee (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568828 Sun, 04 Dec 2011 05:00:00 +0100 5568828 Ndc10 is a platform for inner kinetochore assembly in budding yeast http://www.medworm.com/index.php?rid=5568827&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FWM0g8-xSQMk%2Fnsmb.2178 Authors: Uhn-Soo Cho & Stephen C Harrison (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568827 Sun, 04 Dec 2011 05:00:00 +0100 5568827 A unique H2A histone variant occupies the transcriptional start site of active genes http://www.medworm.com/index.php?rid=5568824&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F2MDhxZDIINg%2Fnsmb.2161 Authors: Tatiana A Soboleva, Maxim Nekrasov, Anuj Pahwa, Rohan Williams, Gavin A Huttley & David J Tremethick (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568824 Sun, 04 Dec 2011 05:00:00 +0100 5568824 RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks http://www.medworm.com/index.php?rid=5568823&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fmo_LnLDJshY%2Fnsmb.2177 Authors: Yoshitami Hashimoto, Fabio Puddu & Vincenzo Costanzo (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5568823 Sun, 04 Dec 2011 05:00:00 +0100 5568823 The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks http://www.medworm.com/index.php?rid=5483068&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FkUhAAo8vRKA%2Fnsmb.2188 Authors: Klara Acs, Martijn S Luijsterburg, Leena Ackermann, Florian A Salomons, Thorsten Hoppe & Nico P Dantuma (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483068 Sun, 27 Nov 2011 05:00:00 +0100 5483068 Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors http://www.medworm.com/index.php?rid=5483066&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F4iR9h1b4Fj0%2Fnsmb.2189 Authors: Matilde Murga, Stefano Campaner, Andres J Lopez-Contreras, Luis I Toledo, Rebeca Soria, Maria F Montaña, Luana D'Artista, Thomas Schleker, Carmen Guerra, Elena Garcia, Mariano Barbacid, Manuel Hidalgo, Bruno Amati & Oscar Fernandez-Capetillo (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483066 Sun, 27 Nov 2011 05:00:00 +0100 5483066 A shared structural solution for neutralizing ebolaviruses http://www.medworm.com/index.php?rid=5483081&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FPeuRlF8BaVI%2Fnsmb.2150 Authors: João M Dias, Ana I Kuehne, Dafna M Abelson, Shridhar Bale, Anthony C Wong, Peter Halfmann, Majidat A Muhammad, Marnie L Fusco, Samantha E Zak, Eugene Kang, Yoshihiro Kawaoka, Kartik Chandran, John M Dye & Erica Ollmann Saphire Sudan virus (genus Ebolavirus) is lethal, yet no monoclonal antibody is known to neutralize it. We here describe antibody 16F6 that neutralizes Sudan virus and present its structure bound to the trimeric viral glycoprotein. Unexpectedly, the 16F6 epitope overlaps that of KZ52, the only other antibody against the GP1,2 core to be visualized to date. Furthermore, both antibodies against this crucial epitope bridging GP1–GP2 neutralize at a post-internalization step—probably fusion. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483081 Sun, 20 Nov 2011 05:00:00 +0100 5483081 Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins http://www.medworm.com/index.php?rid=5483079&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FIMw5_SvZSQo%2Fnsmb.2185 Authors: Konstantinos Tripsianes, Tobias Madl, Martin Machyna, Dimitrios Fessas, Clemens Englbrecht, Utz Fischer, Karla M Neugebauer & Michael Sattler (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483079 Sun, 20 Nov 2011 05:00:00 +0100 5483079 Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast http://www.medworm.com/index.php?rid=5483078&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F0Z2dhfgHM74%2Fnsmb.2187 Authors: Bettina A Moser, Ya-Ting Chang, Jorgena Kosti & Toru M Nakamura (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483078 Sun, 20 Nov 2011 05:00:00 +0100 5483078 The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection http://www.medworm.com/index.php?rid=5483077&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fti2l6DAgCmQ%2Fnsmb.2172 Authors: Rekha Rai, Ju-Mei Li, Hong Zheng, Gabriel Tsz-Mei Lok, Yu Deng, Michael S-Y Huen, Junjie Chen, Jianping Jin & Sandy Chang (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483077 Sun, 20 Nov 2011 05:00:00 +0100 5483077 Mechanistic insights into the activation of oncogenic forms of EGF receptor http://www.medworm.com/index.php?rid=5483075&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FSVuUycmoJNw%2Fnsmb.2168 Authors: Zhihong Wang, Patti A Longo, Mary Katherine Tarrant, Kwangsoo Kim, Sarah Head, Daniel J Leahy & Philip A Cole (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483075 Sun, 20 Nov 2011 05:00:00 +0100 5483075 The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis http://www.medworm.com/index.php?rid=5483072&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FwT50gIOdLaw%2Fnsmb.2174 Authors: Andrea J Berman, Benjamin M Akiyama, Michael D Stone & Thomas R Cech (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483072 Sun, 20 Nov 2011 05:00:00 +0100 5483072 Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway http://www.medworm.com/index.php?rid=5483083&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FkUL3Q5M8WSU%2Fnsmb.2173 Authors: Ivan V Rosado, Frédéric Langevin, Gerry P Crossan, Minoru Takata & Ketan J Patel Metabolism is predicted to generate formaldehyde, a toxic, simple, reactive aldehyde that can damage DNA. Here we report a synthetic lethal interaction in avian cells between ADH5, encoding the main formaldehyde-detoxifying enzyme, and the Fanconi anemia (FA) DNA-repair pathway. These results define a fundamental role for the combined action of formaldehyde catabolism and DNA cross-link repair in vertebrate cell survival. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483083 Sun, 13 Nov 2011 05:00:00 +0100 5483083 RNA targets of wild-type and mutant FET family proteins http://www.medworm.com/index.php?rid=5483082&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F2RaqVFXpJDM%2Fnsmb.2163 Authors: Jessica I Hoell, Erik Larsson, Simon Runge, Jeffrey D Nusbaum, Sujitha Duggimpudi, Thalia A Farazi, Markus Hafner, Arndt Borkhardt, Chris Sander & Thomas Tuschl FUS, EWSR1 and TAF15, constituting the FET protein family, are abundant, highly conserved RNA-binding proteins with important roles in oncogenesis and neuronal disease, yet their RNA targets and recognition elements are unknown. Using PAR-CLIP, we defined global RNA targets for all human FET proteins and two ALS-causing human FUS mutants. FET members showed similar binding profiles, whereas FUS mutants showed a drastically altered binding pattern, consistent with changes in subcellular localization. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483082 Sun, 13 Nov 2011 05:00:00 +0100 5483082 The elongation rate of RNA polymerase determines the fate of transcribed nucleosomes http://www.medworm.com/index.php?rid=5483076&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F7Spql4FO_s8%2Fnsmb.2164 Authors: Lacramioara Bintu, Marta Kopaczynska, Courtney Hodges, Lucyna Lubkowska, Mikhail Kashlev & Carlos Bustamante (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483076 Sun, 13 Nov 2011 05:00:00 +0100 5483076 NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling http://www.medworm.com/index.php?rid=5483074&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F68jr7ly6rP4%2Fnsmb.2152 Authors: Peter D Mace, Yann Wallez, Małgorzata K Dobaczewska, JeongEun J Lee, Howard Robinson, Elena B Pasquale & Stefan J Riedl (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483074 Sun, 13 Nov 2011 05:00:00 +0100 5483074 Recognition of enhancer element–specific histone methylation by TIP60 in transcriptional activation http://www.medworm.com/index.php?rid=5483070&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FL6TQ-nILSIA%2Fnsmb.2153 Authors: Kwang Won Jeong, Kyunghwan Kim, Alan Jialun Situ, Tobias S Ulmer, Woojin An & Michael R Stallcup (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483070 Sun, 13 Nov 2011 05:00:00 +0100 5483070 The Chp1–Tas3 core is a multifunctional platform critical for gene silencing by RITS http://www.medworm.com/index.php?rid=5483069&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F4Yo7GJyZCrw%2Fnsmb.2151 Authors: Thomas Schalch, Godwin Job, Sreenath Shanker, Janet F Partridge & Leemor Joshua-Tor (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483069 Sun, 13 Nov 2011 05:00:00 +0100 5483069 Total RNA sequencing reveals nascent transcription and widespread co-transcriptional splicing in the human brain http://www.medworm.com/index.php?rid=5483084&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FzT8hhJdnS4M%2Fnsmb.2143 Authors: Adam Ameur, Ammar Zaghlool, Jonatan Halvardson, Anna Wetterbom, Ulf Gyllensten, Lucia Cavelier & Lars Feuk (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483084 Sun, 06 Nov 2011 04:00:00 +0100 5483084 Molecular profiling of common fragile sites in human fibroblasts http://www.medworm.com/index.php?rid=5483080&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FA1Vq5WOVxGk%2Fnsmb.2155 Authors: Benoî Le Tallec, Bernard Dutrillaux, Anne-Marie Lachages, Gael Armel Millot, Olivier Brison & Michelle Debatisse Common fragile sites have been mapped primarily in lymphocytes, but recent analyses show that the setting of these sites relies on cell type–dependent replication programs. Using a new approach, we molecularly mapped common fragile sites in human fibroblasts and showed that commitment to fragility depends on similar replication features in fibroblasts and lymphocytes, although different loci are committed in each cell type. Notably, the common fragile sites that we identified overlapped heretofore unexplained deletion clusters observed in tumors. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483080 Sun, 06 Nov 2011 04:00:00 +0100 5483080 Structural basis for the molecular evolution of SRP-GTPase activation by protein http://www.medworm.com/index.php?rid=5483073&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F-7_gBDf-VWQ%2Fnsmb.2141 Authors: Gert Bange, Nico Kümmerer, Przemyslaw Grudnik, Robert Lindner, Georg Petzold, Dieter Kressler, Ed Hurt, Klemens Wild & Irmgard Sinning (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483073 Sun, 06 Nov 2011 04:00:00 +0100 5483073 Structure of green-type Rubisco activase from tobacco http://www.medworm.com/index.php?rid=5483071&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FroTROLXx66g%2Fnsmb.2171 Authors: Mathias Stotz, Oliver Mueller-Cajar, Susanne Ciniawsky, Petra Wendler, F Ulrich Hartl, Andreas Bracher & Manajit Hayer-Hartl (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483071 Sun, 06 Nov 2011 04:00:00 +0100 5483071 Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein http://www.medworm.com/index.php?rid=5483067&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fwm1IiLYlFp8%2Fnsmb.2142 Authors: Hye-Ra Lee, Won-Chan Choi, Stacy Lee, Jungwon Hwang, Eunha Hwang, Koushik Guchhait, Juergen Haas, Zsolt Toth, Young Ho Jeon, Tae-Kwang Oh, Myung Hee Kim & Jae U Jung (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483067 Sun, 06 Nov 2011 04:00:00 +0100 5483067 Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8 http://www.medworm.com/index.php?rid=5483065&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F7hyS-hJYNPQ%2Fnsmb.2165 Authors: Seung Beom Hong, Byeong-Won Kim, Kyung-Eun Lee, Se Woong Kim, Hyesung Jeon, Joon Kim & Hyun Kyu Song (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5483065 Sun, 06 Nov 2011 04:00:00 +0100 5483065 Mediator action http://www.medworm.com/index.php?rid=5375276&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FS9FgsaGg4JE%2Fnsmb.2184 Nature Structural & Molecular Biology 18, 1183 (2011). doi:10.1038/nsmb.2184 Author: Arianne Heinrichs (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375276 Fri, 04 Nov 2011 04:00:00 +0100 5375276 Invading the nucleus http://www.medworm.com/index.php?rid=5375275&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F73bG97_xBxw%2Fnsmb.2183 Nature Structural & Molecular Biology 18, 1183 (2011). doi:10.1038/nsmb.2183 Author: Inês Chen (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375275 Fri, 04 Nov 2011 04:00:00 +0100 5375275 Regulated unloading http://www.medworm.com/index.php?rid=5375274&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FeNie4qskO9w%2Fnsmb.2182 Nature Structural & Molecular Biology 18, 1183 (2011). doi:10.1038/nsmb.2182 Author: Michelle Montoya (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375274 Fri, 04 Nov 2011 04:00:00 +0100 5375274 Acetylating for avidity http://www.medworm.com/index.php?rid=5375273&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FYDAJ9CPYTkY%2Fnsmb.2181 Nature Structural & Molecular Biology 18, 1183 (2011). doi:10.1038/nsmb.2181 Author: Steve Mason (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375273 Fri, 04 Nov 2011 04:00:00 +0100 5375273 New insights in the mechanism of microRNA-mediated target repression http://www.medworm.com/index.php?rid=5375272&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F4p0vIYl-tBA%2Fnsmb.2170 Authors: Markus Hafner, Manuel Ascano & Thomas Tuschl The microRNA-induced silencing complex (miRISC) protein TNRC6 (also called GW182) uses dispersed tryptophan-containing repeats in unstructured regions to recruit the CCR4–NOT nuclease complex leading to mRNA deadenylation and inhibition of translation initiation according to new research. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375272 Fri, 04 Nov 2011 04:00:00 +0100 5375272 TFAM forces mtDNA to make a U-turn http://www.medworm.com/index.php?rid=5375271&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FaiyfxgQoMdA%2Fnsmb.2167 Authors: B Martin Hallberg & Nils-Göran Larsson The mammalian mitochondrial transcription factor A (TFAM) is encoded in the nucleus and imported into mitochondria, where it functions as an activator of mtDNA transcription and packages mtDNA into DNA-protein aggregates called mitochondrial nucleoids. Two studies in this issue reveal that TFAM shapes mtDNA into a sharp U-turn, providing a molecular mechanism for its dual roles in the expression and maintenance of mtDNA. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375271 Fri, 04 Nov 2011 04:00:00 +0100 5375271 The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA http://www.medworm.com/index.php?rid=5375291&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FYmgGNmaihsI%2Fnsmb.2159 Authors: Huu B Ngo, Jens T Kaiser & David C Chan (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375291 Sun, 30 Oct 2011 04:00:00 +0100 5375291 Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter http://www.medworm.com/index.php?rid=5375290&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FEjb3r-Tho7M%2Fnsmb.2160 Authors: Anna Rubio-Cosials, Jasmin F Sidow, Nereida Jiménez-Menéndez, Pablo Fernández-Millán, Julio Montoya, Howard T Jacobs, Miquel Coll, Pau Bernadó & Maria Solà (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375290 Sun, 30 Oct 2011 04:00:00 +0100 5375290 An asymmetric interface between the regulatory and core particles of the proteasome http://www.medworm.com/index.php?rid=5375287&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FAESTt5FaTMU%2Fnsmb.2147 Authors: Geng Tian, Soyeon Park, Min Jae Lee, Bettina Huck, Fiona McAllister, Christopher P Hill, Steven P Gygi & Daniel Finley (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375287 Sun, 30 Oct 2011 04:00:00 +0100 5375287 Messenger RNA interactions in the decoding center control the rate of translocation http://www.medworm.com/index.php?rid=5375293&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FtrHBS9KY1Yc%2Fnsmb.2140 Authors: Prashant K Khade & Simpson Joseph During protein synthesis, mRNA and tRNAs are iteratively translocated by the ribosome. Precisely what molecular event is rate limiting for translocation is not known. Here we show that disruption of the interactions between the A-site codon and the ribosome accelerates translocation, suggesting that the release of the mRNA from the decoding center of the ribosome is the rate-limiting step of translocation. These results provide insight into the molecular mechanism of translocation. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375293 Sun, 23 Oct 2011 04:00:00 +0100 5375293 Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin http://www.medworm.com/index.php?rid=5375286&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FFgm01_u8JEo%2Fnsmb.2148 Authors: Agnieszka Szyk, Alexandra M Deaconescu, Grzegorz Piszczek & Antonina Roll-Mecak (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375286 Sun, 23 Oct 2011 04:00:00 +0100 5375286 ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding http://www.medworm.com/index.php?rid=5375285&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FjR__imLaJ7A%2Fnsmb.2135 Authors: Shalini T Low-Nam, Keith A Lidke, Patrick J Cutler, Rob C Roovers, Paul M P van Bergen en Henegouwen, Bridget S Wilson & Diane S Lidke (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375285 Sun, 23 Oct 2011 04:00:00 +0100 5375285 Structural basis of tRNA agmatinylation essential for AUA codon decoding http://www.medworm.com/index.php?rid=5375289&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FWyxVWxWR-eU%2Fnsmb.2144 Authors: Takuo Osawa, Satoshi Kimura, Naohiro Terasaka, Hideko Inanaga, Tsutomu Suzuki & Tomoyuki Numata (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375289 Sun, 16 Oct 2011 04:00:00 +0100 5375289 Biogenesis of 2-agmatinylcytidine catalyzed by the dual protein and RNA kinase TiaS http://www.medworm.com/index.php?rid=5375288&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FhdwzyVZoi4w%2Fnsmb.2121 Authors: Naohiro Terasaka, Satoshi Kimura, Takuo Osawa, Tomoyuki Numata & Tsutomu Suzuki (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375288 Sun, 16 Oct 2011 04:00:00 +0100 5375288 Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization http://www.medworm.com/index.php?rid=5375284&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F1BFajr5TKxk%2Fnsmb.2154 Authors: Mikyung Kim, Zhen-Yu J Sun, Kasper D Rand, Xiaomeng Shi, Likai Song, Yuxing Cheng, Amr F Fahmy, Shreoshi Majumdar, Gilad Ofek, Yongping Yang, Peter D Kwong, Jia-Huai Wang, John R Engen, Gerhard Wagner & Ellis L Reinherz (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375284 Sun, 16 Oct 2011 04:00:00 +0100 5375284 Initiation factor eIF2γ promotes eIF2–GTP–Met-tRNAiMet ternary complex binding to the 40S ribosome http://www.medworm.com/index.php?rid=5375283&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F8wocDn8aLeQ%2Fnsmb.2133 Authors: Byung-Sik Shin, Joo-Ran Kim, Sarah E Walker, Jinsheng Dong, Jon R Lorsch & Thomas E Dever (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375283 Sun, 16 Oct 2011 04:00:00 +0100 5375283 Crystal structures of aprataxin ortholog Hnt3 reveal the mechanism for reversal of 5′-adenylated DNA http://www.medworm.com/index.php?rid=5375292&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FAxDmHMSxm84%2Fnsmb.2145 Authors: Yong Gong, Deyu Zhu, Jingjin Ding, Chuan-Na Dou, Xiaoming Ren, Lichuan Gu, Tao Jiang & Da-Cheng Wang Aprataxin is a DNA deadenylase that resolves DNA 5′-AMP termini and reverses abortive DNA ligation. The crystal structures of Schizosaccharomyces pombe aprataxin Hnt3 in its apo form and in complex to dsDNA and dsDNA–AMP reveal how Hnt3 recognizes and processes 5′-adenylated DNA in a structure-specific manner. The bound DNA adopts a 5′-flap conformation that facilitates 5′-AMP access to the active site, where AMP cleavage occurs by a canonical catalytic mechanism. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375292 Sun, 09 Oct 2011 04:00:00 +0100 5375292 Crystal structures of the extracellular domain of LRP6 and its complex with DKK1 http://www.medworm.com/index.php?rid=5375280&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FnwJk8M0y8Hs%2Fnsmb.2139 Authors: Zhihong Cheng, Travis Biechele, Zhiyi Wei, Seamus Morrone, Randall T Moon, Liguo Wang & Wenqing Xu (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375280 Sun, 09 Oct 2011 04:00:00 +0100 5375280 Structure and nucleosome interaction of the yeast NuA4 and Piccolo–NuA4 histone acetyltransferase complexes http://www.medworm.com/index.php?rid=5375279&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FUu4sxguMOUE%2Fnsmb.2128 Authors: Johnathan R Chittuluru, Yuriy Chaban, Julie Monnet-Saksouk, Michael J Carrozza, Vasileia Sapountzi, William Selleck, Jiehuan Huang, Rhea T Utley, Myriam Cramet, Stephane Allard, Gang Cai, Jerry L Workman, Michael G Fried, Song Tan, Jacques Côté & Francisco J Asturias (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375279 Sun, 09 Oct 2011 04:00:00 +0100 5375279 Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease http://www.medworm.com/index.php?rid=5375278&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FGRkPKP6v6aw%2Fnsmb.2146 Authors: Percy Tumbale, C Denise Appel, Rolf Kraehenbuehl, Patrick D Robertson, Jessica S Williams, Joe Krahn, Ivan Ahel & R Scott Williams (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375278 Sun, 09 Oct 2011 04:00:00 +0100 5375278 Two classes of silencing RNAs move between Caenorhabditis elegans tissues http://www.medworm.com/index.php?rid=5375277&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FyPJbEEXdbpk%2Fnsmb.2134 Authors: Antony M Jose, Giancarlo A Garcia & Craig P Hunter (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375277 Sun, 09 Oct 2011 04:00:00 +0100 5375277 miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs http://www.medworm.com/index.php?rid=5375282&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FLzjgjAx-6I4%2Fnsmb.2166 Authors: Marina Chekulaeva, Hansruedi Mathys, Jakob T Zipprich, Jan Attig, Marija Colic, Roy Parker & Witold Filipowicz (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375282 Fri, 07 Oct 2011 04:00:00 +0100 5375282 miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT http://www.medworm.com/index.php?rid=5375281&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FxjsNXfhVLgA%2Fnsmb.2149 Authors: Marc R Fabian, Maja K Cieplak, Filipp Frank, Masahiro Morita, Jonathan Green, Tharan Srikumar, Bhushan Nagar, Tadashi Yamamoto, Brian Raught, Thomas F Duchaine & Nahum Sonenberg (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5375281 Fri, 07 Oct 2011 04:00:00 +0100 5375281 Signaling through chromatin http://www.medworm.com/index.php?rid=5301820&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FTfJaFzdtN7M%2Fnsmb.2158 Nature Structural & Molecular Biology 18, 1085 (2011). doi:10.1038/nsmb.2158 Author: Arianne Heinrichs (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301820 Fri, 07 Oct 2011 04:00:00 +0100 5301820 Sense after shifting http://www.medworm.com/index.php?rid=5301819&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F0QAyYE3kTuI%2Fnsmb.2157 Nature Structural & Molecular Biology 18, 1085 (2011). doi:10.1038/nsmb.2157 Author: Joshua M Finkelstein (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301819 Fri, 07 Oct 2011 04:00:00 +0100 5301819 Nucleoid organization http://www.medworm.com/index.php?rid=5301818&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FW27Dw7ktbtI%2Fnsmb.2156 Nature Structural & Molecular Biology 18, 1085 (2011). doi:10.1038/nsmb.2156 Author: Inês Chen (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301818 Fri, 07 Oct 2011 04:00:00 +0100 5301818 The export factor Yra1 modulates mRNA 3′ end processing http://www.medworm.com/index.php?rid=5301832&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F_N_bSuQ2Lw0%2Fnsmb.2126 Authors: Sara A Johnson, Hyunmin Kim, Benjamin Erickson & David L Bentley (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301832 Sun, 25 Sep 2011 04:00:00 +0100 5301832 Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis http://www.medworm.com/index.php?rid=5301824&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F9S3tCLv54PY%2Fnsmb.2127 Authors: Ulrich Eckhard, Esther Schönauer, Dorota Nüss & Hans Brandstetter (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301824 Sun, 25 Sep 2011 04:00:00 +0100 5301824 Crystal structure of a monomeric retroviral protease solved by protein folding game players http://www.medworm.com/index.php?rid=5301834&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FRc1WiC33Qqo%2Fnsmb.2119 Authors: Firas Khatib, Frank DiMaio, Seth Cooper, Maciej Kazmierczyk, Miroslaw Gilski, Szymon Krzywda, Helena Zabranska, Iva Pichova, James Thompson, Zoran Popović, Mariusz Jaskolski & David Baker Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301834 Sun, 18 Sep 2011 04:00:00 +0100 5301834 Recognition of the pre-miRNA structure by Drosophila Dicer-1 http://www.medworm.com/index.php?rid=5301830&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FL3OgmqYkbVU%2Fnsmb.2125 Recognition of the pre-miRNA structure by Drosophila Dicer-1 Nature Structural & Molecular Biology 18, 1153 (2011). doi:10.1038/nsmb.2125 Authors: Akihisa Tsutsumi, Tomoko Kawamata, Natsuko Izumi, Hervé Seitz & Yukihide Tomari (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301830 Sun, 18 Sep 2011 04:00:00 +0100 5301830 Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site http://www.medworm.com/index.php?rid=5301823&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fl-UfVfMsE-o%2Fnsmb.2120 Authors: Moran Grossman, Benjamin Born, Matthias Heyden, Dmitry Tworowski, Gregg B Fields, Irit Sagi & Martina Havenith (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301823 Sun, 18 Sep 2011 04:00:00 +0100 5301823 Protonation of key acidic residues is critical for the K+-selectivity of the Na/K pump http://www.medworm.com/index.php?rid=5301831&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FxVdf-Qy7CvE%2Fnsmb.2113 Authors: Haibo Yu, Ian M Ratheal, Pablo Artigas & Benoît Roux (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301831 Sun, 11 Sep 2011 04:00:00 +0100 5301831 Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum http://www.medworm.com/index.php?rid=5301829&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FJu6N8wL8WRc%2Fnsmb.2111 Authors: Ethan J Greenblatt, James A Olzmann & Ron R Kopito (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301829 Sun, 11 Sep 2011 04:00:00 +0100 5301829 Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs http://www.medworm.com/index.php?rid=5301828&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FGXUGTDP53qg%2Fnsmb.2115 Authors: David M Garcia, Daehyun Baek, Chanseok Shin, George W Bell, Andrew Grimson & David P Bartel (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301828 Sun, 11 Sep 2011 04:00:00 +0100 5301828 Competition between ADAR and RNAi pathways for an extensive class of RNA targets http://www.medworm.com/index.php?rid=5301822&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FQDqtq5BlAXc%2Fnsmb.2129 Authors: Diane Wu, Ayelet T Lamm & Andrew Z Fire (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301822 Sun, 11 Sep 2011 04:00:00 +0100 5301822 Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes http://www.medworm.com/index.php?rid=5204144&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fw7eDbj2x3YU%2Fnsmb0911-1084d Nature Structural & Molecular Biology 18, 1084 (2011). doi:10.1038/nsmb0911-1084d Author: David Martin, Cristina Pantoja, Ana Fernández Miñán, Christian Valdes-Quezada, Eduardo Moltó, Fuencisla Matesanz, Ozren Bogdanović, Elisa de la Calle-Mustienes, Orlando Domínguez, Leila Taher, Mayra Furlan-Magaril, Antonio Alcina, Susana Cañón, María Fedetz, María A Blasco, Paulo S Pereira, Ivan Ovcharenko, Félix Recillas-Targa, Lluís Montoliu, Miguel Manzanares, Roderic Guigó, Manuel Serrano, Fernando Casares & José Luis Gómez-Skarmeta (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204144 Tue, 06 Sep 2011 04:00:00 +0100 5204144 ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair http://www.medworm.com/index.php?rid=5204143&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Ffmp0UbS3mFU%2Fnsmb0911-1084c Nature Structural & Molecular Biology 18, 1084 (2011). doi:10.1038/nsmb0911-1084c Author: Gareth J Williams, R Scott Williams, Jessica S Williams, Gabriel Moncalian, Andrew S Arvai, Oliver Limbo, Grant Guenther, Soumita SilDas, Michal Hammel, Paul Russell & John A Tainer (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204143 Tue, 06 Sep 2011 04:00:00 +0100 5204143 The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis http://www.medworm.com/index.php?rid=5204142&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fakz8uYeax80%2Fnsmb0911-1084b Nature Structural & Molecular Biology 18, 1084 (2011). doi:10.1038/nsmb0911-1084b Author: Dmitry V Bugreev, Roberto J Pezza, Olga M Mazina, Oleg N Voloshin, R Daniel Camerini-Otero & Alexander V Mazin (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204142 Tue, 06 Sep 2011 04:00:00 +0100 5204142 Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs http://www.medworm.com/index.php?rid=5204141&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F2fILd_7q6qc%2Fnsmb0911-1084a Nature Structural & Molecular Biology 18, 1084 (2011). doi:10.1038/nsmb0911-1084a Author: Anthony K L Leung, Amanda G Young, Arjun Bhutkar, Grace X Zheng, Andrew D Bosson, Cydney B Nielsen & Phillip A Sharp (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204141 Tue, 06 Sep 2011 04:00:00 +0100 5204141 Border protection http://www.medworm.com/index.php?rid=5204125&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FZsxvgiZMJ98%2Fnsmb.2138 Nature Structural & Molecular Biology 18, 970 (2011). doi:10.1038/nsmb.2138 Author: Inês Chen (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204125 Tue, 06 Sep 2011 04:00:00 +0100 5204125 Heating up the nuclear pore http://www.medworm.com/index.php?rid=5204124&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FODa3g87QoLM%2Fnsmb.2137 Nature Structural & Molecular Biology 18, 970 (2011). doi:10.1038/nsmb.2137 Author: Joshua M Finkelstein (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204124 Tue, 06 Sep 2011 04:00:00 +0100 5204124 Ribose production on demand http://www.medworm.com/index.php?rid=5204123&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FzNuhAbpkhmM%2Fnsmb.2136 Nature Structural & Molecular Biology 18, 970 (2011). doi:10.1038/nsmb.2136 Author: Arianne Heinrichs (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204123 Tue, 06 Sep 2011 04:00:00 +0100 5204123 A new twist in actin filament nucleation http://www.medworm.com/index.php?rid=5204122&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Ft0PQCsFi5RQ%2Fnsmb.2130 Nature Structural & Molecular Biology 18, 967 (2011). doi:10.1038/nsmb.2130 Author: Marie-France Carlier One of the most versatile regulators of actin assembly, the WASP homology 2 (WH2) domain, reveals previously unknown facets by combining with a newly discovered actin-nucleating dimeric structure in the effector protein VopL from Vibrio parahaemolyticus. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204122 Tue, 06 Sep 2011 04:00:00 +0100 5204122 Jonathan Widom 1955–2011 http://www.medworm.com/index.php?rid=5204121&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FNotmogc-vq4%2Fnsmb.2132 Jonathan Widom 1955–2011 Nature Structural & Molecular Biology 18, 965 (2011). doi:10.1038/nsmb.2132 Author: Jeffrey Hayes (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204121 Tue, 06 Sep 2011 04:00:00 +0100 5204121 Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor http://www.medworm.com/index.php?rid=5301833&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F4UE96rnjDhw%2Fnsmb.2112 We report the crystal structures of the ligand-binding domain (LBD) of a rat inositol 1,4,5-trisphosphate receptor (InsP3R) in its apo and InsP3-bound conformations. Comparison of these two conformations reveals that LBD's first β-trefoil fold (β-TF1) and armadillo repeat fold (ARF) move together as a unit relative to its second β-trefoil fold (β-TF2). Whereas apo LBD may spontaneously transition between gating conformations, InsP3 binding shifts this equilibrium toward the active state. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301833 Sun, 04 Sep 2011 04:00:00 +0100 5301833 Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin http://www.medworm.com/index.php?rid=5301827&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FW3Ta_ctDPxI%2Fnsmb.2122 Authors: Francisca E Reyes-Turcu, Ke Zhang, Martin Zofall, Eesin Chen & Shiv I S Grewal (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301827 Sun, 04 Sep 2011 04:00:00 +0100 5301827 The Rad50 coiled-coil domain is indispensable for Mre11 complex functions http://www.medworm.com/index.php?rid=5301826&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FIV-RQLjvmqk%2Fnsmb.2116 Authors: Marcel Hohl, Youngho Kwon, Sandra Muñoz Galván, Xiaoyu Xue, Cristina Tous, Andrés Aguilera, Patrick Sung & John H J Petrini (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301826 Sun, 04 Sep 2011 04:00:00 +0100 5301826 Spliceosome assembly is coupled to RNA polymerase II dynamics at the 3′ end of human genes http://www.medworm.com/index.php?rid=5301825&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fup3z3E5BIj0%2Fnsmb.2124 Authors: Sandra Bento Martins, José Rino, Teresa Carvalho, Célia Carvalho, Minoru Yoshida, Jasmim Mona Klose, Sérgio Fernandes de Almeida & Maria Carmo-Fonseca (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301825 Sun, 04 Sep 2011 04:00:00 +0100 5301825 Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53 http://www.medworm.com/index.php?rid=5301821&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F0U5SmOTgL2A%2Fnsmb.2114 Authors: Franz Hagn, Stephan Lagleder, Marco Retzlaff, Julia Rohrberg, Oliver Demmer, Klaus Richter, Johannes Buchner & Horst Kessler (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5301821 Sun, 04 Sep 2011 04:00:00 +0100 5301821 Mechanism of actin filament nucleation by the bacterial effector VopL http://www.medworm.com/index.php?rid=5204139&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fxcm9piYUgoQ%2Fnsmb.2110 Authors: Bingke Yu, Hui-Chun Cheng, Chad A Brautigam, Diana R Tomchick & Michael K Rosen (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204139 Sun, 28 Aug 2011 04:00:00 +0100 5204139 Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation http://www.medworm.com/index.php?rid=5204138&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FvyRcHczHG7M%2Fnsmb.2109 Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation Nature Structural & Molecular Biology 18, 1060 (2011). doi:10.1038/nsmb.2109 Authors: Suk Namgoong, Malgorzata Boczkowska, Michael J Glista, Jonathan D Winkelman, Grzegorz Rebowski, David R Kovar & Roberto Dominguez (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204138 Sun, 28 Aug 2011 04:00:00 +0100 5204138 Mechanism of ubiquitylation by dimeric RING ligase RNF4 http://www.medworm.com/index.php?rid=5204137&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FOrRfQSH-rvA%2Fnsmb.2108 Authors: Anna Plechanovová, Ellis G Jaffray, Stephen A McMahon, Kenneth A Johnson, Iva Navrátilová, James H Naismith & Ronald T Hay (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204137 Sun, 21 Aug 2011 04:00:00 +0100 5204137 Transfer RNA–mediated regulation of ribosome dynamics during protein synthesis http://www.medworm.com/index.php?rid=5204136&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FFxQ-adaLHTk%2Fnsmb.2098 Authors: Jingyi Fei, Arianne C Richard, Jonathan E Bronson & Ruben L Gonzalez (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204136 Sun, 21 Aug 2011 04:00:00 +0100 5204136 The structural basis of RNA-catalyzed RNA polymerization http://www.medworm.com/index.php?rid=5204135&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fb6-N8QNbFbM%2Fnsmb.2107 Authors: David M Shechner & David P Bartel (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204135 Sun, 21 Aug 2011 04:00:00 +0100 5204135 An unusual dimeric structure and assembly for TLR4 regulator RP105–MD-1 http://www.medworm.com/index.php?rid=5204134&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FeuBeApc8lU8%2Fnsmb.2106 Authors: Sung-il Yoon, Minsun Hong & Ian A Wilson (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204134 Sun, 21 Aug 2011 04:00:00 +0100 5204134 A universal pathway for kinesin stepping http://www.medworm.com/index.php?rid=5204133&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fcp7ocftPU7E%2Fnsmb.2104 Authors: Bason E Clancy, William M Behnke-Parks, Johan O L Andreasson, Steven S Rosenfeld & Steven M Block (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204133 Sun, 14 Aug 2011 04:00:00 +0100 5204133 Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation http://www.medworm.com/index.php?rid=5204132&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FCFJDwreS1Sw%2Fnsmb.2105 Authors: Xuefeng Chen, Hengyao Niu, Woo-Hyun Chung, Zhu Zhu, Alma Papusha, Eun Yong Shim, Sang Eun Lee, Patrick Sung & Grzegorz Ira (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204132 Sun, 14 Aug 2011 04:00:00 +0100 5204132 The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling http://www.medworm.com/index.php?rid=5204126&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fr_o986PDyEE%2Fnsmb.2099 Authors: Daniela Ungureanu, Jinhua Wu, Tuija Pekkala, Yashavanthi Niranjan, Clifford Young, Ole N Jensen, Chong-Feng Xu, Thomas A Neubert, Radek C Skoda, Stevan R Hubbard & Olli Silvennoinen (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204126 Sun, 14 Aug 2011 04:00:00 +0100 5204126 Biogenic mechanisms and utilization of small RNAs derived from human protein-coding genes http://www.medworm.com/index.php?rid=5204140&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FmVt2jbjRCBU%2Fnsmb.2091 Authors: Eivind Valen, Pascal Preker, Peter Refsing Andersen, Xiaobei Zhao, Yun Chen, Christine Ender, Anne Dueck, Gunter Meister, Albin Sandelin & Torben Heick Jensen (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204140 Sun, 07 Aug 2011 04:00:00 +0100 5204140 Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition http://www.medworm.com/index.php?rid=5204131&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FS4m1AmZCY1A%2Fnsmb.2097 Authors: Elena Khazina, Vincent Truffault, Regina Büttner, Steffen Schmidt, Murray Coles & Oliver Weichenrieder (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204131 Sun, 07 Aug 2011 04:00:00 +0100 5204131 An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation http://www.medworm.com/index.php?rid=5204130&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FOd-Qcna3-Ng%2Fnsmb.2095 Authors: Angeline M Lyon, Valerie M Tesmer, Vishan D Dhamsania, David M Thal, Joanne Gutierrez, Shoaib Chowdhury, Krishna C Suddala, John K Northup & John J G Tesmer (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204130 Sun, 07 Aug 2011 04:00:00 +0100 5204130 Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP http://www.medworm.com/index.php?rid=5204129&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FJ0pSJ7CZBgk%2Fnsmb.2094 Authors: Marianna Teplova, Lara Wohlbold, Nyan W Khin, Elisa Izaurralde & Dinshaw J Patel (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204129 Sun, 07 Aug 2011 04:00:00 +0100 5204129 Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor http://www.medworm.com/index.php?rid=5204128&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F7ncVQXS4I94%2Fnsmb.2092 Authors: Li-Zhi Mi, Chafen Lu, Zongli Li, Noritaka Nishida, Thomas Walz & Timothy A Springer (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204128 Sun, 07 Aug 2011 04:00:00 +0100 5204128 Research highlights http://www.medworm.com/index.php?rid=5094269&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FWuOhyG8-xyI%2Fnsmb0811-866 Nature Structural & Molecular Biology 18, 866 (2011). doi:10.1038/nsmb0811-866 Author: Inês Chen, Arianne Heinrichs, Sabbi Lall & Steve Mason (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5094269 Tue, 02 Aug 2011 23:00:00 +0100 5094269 A bottle opener for TBP http://www.medworm.com/index.php?rid=5094268&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FmZ50X_T4ez4%2Fnsmb0811-865 Nature Structural & Molecular Biology 18, 865 (2011). doi:10.1038/nsmb0811-865 Author: Sabbi Lall (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5094268 Tue, 02 Aug 2011 23:00:00 +0100 5094268 Conformational flexibility and rotation of the RING domain in activation of cullin–RING ligases http://www.medworm.com/index.php?rid=5094267&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FBiRBtJLHSMA%2Fnsmb.2117 Conformational flexibility and rotation of the RING domain in activation of cullin–RING ligases Nature Structural & Molecular Biology 18, 863 (2011). doi:10.1038/nsmb.2117 Authors: Simin Rahighi & Ivan Dikic The RING protein RBX-1 is implicated in both NEDDylation and ubiquitylation reactions. In this issue, new structural analysis reveals how conformational flexibility of the RBX-1 linker allows for a marked reorientation of the CUL1–RBX1 complex to facilitate transfer of NEDD8 or ubiquitin by closing the gap between the E2 catalytic site and the substrate. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5094267 Tue, 02 Aug 2011 23:00:00 +0100 5094267 Complexin arrests a neighbor http://www.medworm.com/index.php?rid=5094266&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fj-4NrcAlp2I%2Fnsmb.2118 Nature Structural & Molecular Biology 18, 861 (2011). doi:10.1038/nsmb.2118 Author: Keith R Weninger Mechanistic details about complexin's contradictory double life as both a facilitator and an inhibitor of SNARE-mediated synaptic vesicle fusion have been challenging to uncover. A series of studies in this issue addresses the problem by revealing a switchable complexin conformation in which fusion arrest occurs when complexin clamps neighboring SNAREs. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5094266 Tue, 02 Aug 2011 23:00:00 +0100 5094266 Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36 http://www.medworm.com/index.php?rid=5204127&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FL48m3BXPCg4%2Fnsmb.2123 Authors: Sérgio Fernandes de Almeida, Ana Rita Grosso, Frederic Koch, Romain Fenouil, Sílvia Carvalho, Jorge Andrade, Helena Levezinho, Marta Gut, Dirk Eick, Ivo Gut, Jean-Christophe Andrau, Pierre Ferrier & Maria Carmo-Fonseca (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5204127 Tue, 26 Jul 2011 04:00:00 +0100 5204127 Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state http://www.medworm.com/index.php?rid=5094281&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FbJtk8PDZzJo%2Fnsmb.2102 Authors: Feng Li, Frédéric Pincet, Eric Perez, Claudio G Giraudo, David Tareste & James E Rothman (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5094281 Sat, 23 Jul 2011 23:00:00 +0100 5094281 A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion http://www.medworm.com/index.php?rid=5094280&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fpav99x8cvNs%2Fnsmb.2103 Authors: Shyam S Krishnakumar, Daniel T Radoff, Daniel Kümmel, Claudio G Giraudo, Feng Li, Lavan Khandan, Stephanie Wood Baguley, Jeff Coleman, Karin M Reinisch, Frederic Pincet & James E Rothman (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5094280 Sat, 23 Jul 2011 23:00:00 +0100 5094280 Complexin cross-links prefusion SNAREs into a zigzag array http://www.medworm.com/index.php?rid=5094279&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Ftvyy3Q-b8VQ%2Fnsmb.2101 Authors: Daniel Kümmel, Shyam S Krishnakumar, Daniel T Radoff, Feng Li, Claudio G Giraudo, Frederic Pincet, James E Rothman & Karin M Reinisch (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5094279 Sat, 23 Jul 2011 23:00:00 +0100 5094279 Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters http://www.medworm.com/index.php?rid=5094284&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FLjLrEYdaLc0%2Fnsmb.2085 Authors: Frederic Koch, Romain Fenouil, Marta Gut, Pierre Cauchy, Thomas K Albert, Joaquin Zacarias-Cabeza, Salvatore Spicuglia, Albane Lamy de la Chapelle, Martin Heidemann, Corinna Hintermair, Dirk Eick, Ivo Gut, Pierre Ferrier & Jean-Christophe Andrau (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5094284 Sat, 16 Jul 2011 23:00:00 +0100 5094284 A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases http://www.medworm.com/index.php?rid=5094282&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FMM_G8vZhEAA%2Fnsmb.2086 Authors: Matthew F Calabrese, Daniel C Scott, David M Duda, Christy R R Grace, Igor Kurinov, Richard W Kriwacki & Brenda A Schulman How RING E3 ligases mediate E2-to-substrate ubiquitin-like protein (UBL) transfer remains unknown. Here we address how the RING E3 RBX1 positions NEDD8's E2 (UBC12) and substrate (CUL1). We find that existing structures are incompatible with CUL1 NEDD8ylation and report a new conformation of RBX1 that places UBC12 adjacent to CUL1. We propose RING domain rotation as a general mechanism for UBL transfer for the largest family of E3s. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=5094282 Sat, 16 Jul 2011 23:00:00 +0100 5094282