Nature Structural and Molecular Biology via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nature Structural and Molecular Biology' source. Sun, 21 Feb 2010 16:03:57 +0100 Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy http://www.medworm.com/index.php?rid=3114533&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FZxaYqjczS7Q%2Fnsmb1209-1331b Nature Structural & Molecular Biology 16, 1331 (2009). doi:10.1038/nsmb1209-1331b Author: Raul Perez-Jimenez, Jingyuan Li, Pallav Kosuri, Inmaculada Sanchez-Romero, Arun P Wiita, David Rodriguez-Larrea, Ana Chueca, Arne Holmgren, Antonio Miranda-Vizuete, Katja Becker, Seung-Hyun Cho, Jon Beckwith, Eric Gelhaye, Jean P Jacquot, Eric A Gaucher, Jose M Sanchez-Ruiz, Bruce J Berne & Julio M Fernandez (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114533 Wed, 23 Dec 2009 15:53:48 +0100 3114533 Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14 http://www.medworm.com/index.php?rid=3114532&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FdXjMqoDoHGE%2Fnsmb1209-1331a Nature Structural & Molecular Biology 16, 1331 (2009). doi:10.1038/nsmb1209-1331a Author: Rafael S Depetris, Jinhua Wu & Stevan R Hubbard (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114532 Wed, 23 Dec 2009 15:53:48 +0100 3114532 Research highlights http://www.medworm.com/index.php?rid=3114513&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F4D7j1c4_CL4%2Fnsmb1209-1211 Nature Structural & Molecular Biology 16, 1211 (2009). doi:10.1038/nsmb1209-1211 (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114513 Wed, 23 Dec 2009 15:53:48 +0100 3114513 Ubiquitin linkages make a difference http://www.medworm.com/index.php?rid=3114512&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FjrNo5MJZilI%2Fnsmb1209-1209 Authors: Ivan Dikic & Volker Dötsch Ubiquitin chains have critical roles in activating the NF-κB pathway and mediating immune responses. Recent structural work on distinct ubiquitin chains in complexes with selective ubiquitin-binding domains provides an explanation for directionality and specificity in the NF-κB pathway. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114512 Wed, 23 Dec 2009 15:53:48 +0100 3114512 Flu BM2 structure and function http://www.medworm.com/index.php?rid=3114511&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F4fEJ4JTuRyo%2Fnsmb1209-1207 Nature Structural & Molecular Biology 16, 1207 (2009). doi:10.1038/nsmb1209-1207 Author: Timothy A Cross Flu viruses package essential functions into a small integral membrane protein known as M2. Such small membrane proteins represent major challenges for structural biology. A new study presented in this issue details the structure and functions of the influenza B M2 protein through the use of functional domain–specific solution NMR spectroscopy. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114511 Wed, 23 Dec 2009 15:53:48 +0100 3114511 Chromosome end protection becomes even more complex http://www.medworm.com/index.php?rid=3114510&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fk51ctpogvZg%2Fnsmb1209-1205 Nature Structural & Molecular Biology 16, 1205 (2009). doi:10.1038/nsmb1209-1205 Author: Jan Karlseder Chromosome end protection is accomplished by telomeres. How cells cope with spontaneously unprotected telomeres while avoiding cell cycle arrest or cell death is a fascinating question. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114510 Wed, 23 Dec 2009 15:53:48 +0100 3114510 Warren L. DeLano 21 June 1972–3 November 2009 http://www.medworm.com/index.php?rid=3114509&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FO_CsoySrffw%2Fnsmb1209-1202 Warren L. DeLano 21 June 1972–3 November 2009 Nature Structural & Molecular Biology 16, 1202 (2009). doi:10.1038/nsmb1209-1202 Authors: Axel T Brunger & James A Wells (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114509 Wed, 23 Dec 2009 15:53:48 +0100 3114509 Come together, right now http://www.medworm.com/index.php?rid=3114508&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FuLh_OLOY9k4%2Fnsmb1209-1201 Nature Structural & Molecular Biology 16, 1201 (2009). doi:10.1038/nsmb1209-1201 Some bacteria have the remarkable ability to switch from a free-swimming, planktonic phase to coexistence in a complex biofilm. In this issue of NSMB, the structures of the ligand-bound c-di-GMP riboswitch give insight into some of the molecular processes linked to lifestyle changes but also suggest a potential avenue for applications that begs exploration. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114508 Wed, 23 Dec 2009 15:53:48 +0100 3114508 Mechanism of potassium-channel selectivity revealed by Na+ and Li+ binding sites within the KcsA pore http://www.medworm.com/index.php?rid=3114529&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FXD21som4HNI%2Fnsmb.1703 Authors: Ameer N Thompson, Ilsoo Kim, Timothy D Panosian, Tina M Iverson, Toby W Allen & Crina M Nimigean (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114529 Sun, 29 Nov 2009 00:00:00 +0100 3114529 Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins http://www.medworm.com/index.php?rid=3114521&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F53i2soFSJuA%2Fnsmb.1712 Authors: Bingbing Wang, Shuqiang Li, Hank H Qi, Dipanjan Chowdhury, Yang Shi & Carl D Novina (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114521 Sun, 29 Nov 2009 00:00:00 +0100 3114521 Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain http://www.medworm.com/index.php?rid=3114531&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FjAnaRpQHCmQ%2Fnsmb.1731 Authors: Yogesh Kulathu, Masato Akutsu, Anja Bremm, Kay Hofmann & David Komander The protein kinase TAK1 is activated by binding to Lys63 (K63)-linked ubiquitin chains through its subunit TAB2. Here we analyze crystal structures of the TAB2 NZF domain bound to Lys63-linked di- and triubiquitin, revealing that TAB2 binds adjacent ubiquitin moieties via two distinct binding sites. The conformational constraints imposed by TAB2 on a Lys63 dimer cannot be adopted by linear chains, explaining why TAK1 cannot be activated by linear ubiquitination events. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114531 Sun, 22 Nov 2009 00:00:00 +0100 3114531 Mechanism of chromatin remodeling and recovery during passage of RNA polymerase II http://www.medworm.com/index.php?rid=3114523&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FmmuVSa-QXjM%2Fnsmb.1689 Authors: Olga I Kulaeva, Daria A Gaykalova, Nikolai A Pestov, Viktor V Golovastov, Dmitry G Vassylyev, Irina Artsimovitch & Vasily M Studitsky (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114523 Sun, 22 Nov 2009 00:00:00 +0100 3114523 Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions http://www.medworm.com/index.php?rid=3114519&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FfkBFARED7Ps%2Fnsmb.1725 Authors: Anthony J Cesare, Zeenia Kaul, Scott B Cohen, Christine E Napier, Hilda A Pickett, Axel A Neumann & Roger R Reddel (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114519 Sun, 22 Nov 2009 00:00:00 +0100 3114519 Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components http://www.medworm.com/index.php?rid=3114518&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FksOUMUEICzE%2Fnsmb.1729 Authors: Zbigniew Warkocki, Peter Odenwälder, Jana Schmitzová, Florian Platzmann, Holger Stark, Henning Urlaub, Ralf Ficner, Patrizia Fabrizio & Reinhard Lührmann (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114518 Sun, 22 Nov 2009 00:00:00 +0100 3114518 IDN1 and IDN2 are required for de novo DNA methylation in Arabidopsis thaliana http://www.medworm.com/index.php?rid=3114530&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FNHc-rSOoLF0%2Fnsmb.1690 Authors: Israel Ausin, Todd C Mockler, Joanne Chory & Steven E Jacobsen DNA methylation is an epigenetic mark affecting genes and transposons. Screening for mutants that fail to establish DNA methylation yielded two we termed “involved in de novo” (idn) 1 and 2. IDN1 encodes DMS3, an SMC-related protein, and IDN2 encodes a previously unknown double-stranded RNA–binding protein with homology to SGS3. IDN1 and IDN2 control de novo methylation and small interfering RNA (siRNA)-mediated maintenance methylation and are components of the RNA-directed DNA methylation pathway. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114530 Sun, 15 Nov 2009 00:00:00 +0100 3114530 A stepwise 2′-hydroxyl activation mechanism for the bacterial transcription termination factor Rho helicase http://www.medworm.com/index.php?rid=3114528&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FLfrSk6N_w6I%2Fnsmb.1711 A stepwise 2′-hydroxyl activation mechanism for the bacterial transcription termination factor Rho helicase Nature Structural & Molecular Biology 16, 1309 (2009). doi:10.1038/nsmb.1711 Authors: Annie Schwartz, Makhlouf Rabhi, Frédérique Jacquinot, Emmanuel Margeat, A Rachid Rahmouni & Marc Boudvillain (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114528 Sun, 15 Nov 2009 00:00:00 +0100 3114528 The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A http://www.medworm.com/index.php?rid=3114527&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FhBZvbtLPEP0%2Fnsmb.1708 Authors: Ai Takemoto, Kazuhiro Maeshima, Tsuyoshi Ikehara, Kazumitsu Yamaguchi, Akiko Murayama, Shihoko Imamura, Naoko Imamoto, Shigeyuki Yokoyama, Tatsuya Hirano, Yoshinori Watanabe, Fumio Hanaoka, Junn Yanagisawa & Keiji Kimura (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114527 Sun, 15 Nov 2009 00:00:00 +0100 3114527 An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe http://www.medworm.com/index.php?rid=3114525&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F0rd8gbhbPkw%2Fnsmb.1688 Authors: Hyun-Soo Kim, Vincent Vanoosthuyse, Jeffrey Fillingham, Assen Roguev, Stephen Watt, Thomas Kislinger, Alex Treyer, Laura Rocco Carpenter, Christopher S Bennett, Andrew Emili, Jack F Greenblatt, Kevin G Hardwick, Nevan J Krogan, Jürg Bähler & Michael-Christopher Keogh (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114525 Sun, 15 Nov 2009 00:00:00 +0100 3114525 The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation http://www.medworm.com/index.php?rid=3114524&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FHPxLSvxkQgs%2Fnsmb.1700 Authors: Stephen Tam, Christoph Spiess, William Auyeung, Lukasz Joachimiak, Bryan Chen, Michelle A Poirier & Judith Frydman (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114524 Sun, 15 Nov 2009 00:00:00 +0100 3114524 Physical determinants of strong voltage sensitivity of K+ channel block http://www.medworm.com/index.php?rid=3114520&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FU37y9clbK9M%2Fnsmb.1717 Authors: Yanping Xu, Hyeon-Gyu Shin, Szilvia Szép & Zhe Lu (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114520 Sun, 15 Nov 2009 00:00:00 +0100 3114520 Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters http://www.medworm.com/index.php?rid=3114526&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F4EB8YaKkXZw%2Fnsmb.1704 Authors: Alessandra Picollo, Mattia Malvezzi, Jon C D Houtman & Alessio Accardi (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114526 Sun, 08 Nov 2009 00:00:00 +0100 3114526 Solution structure and functional analysis of the influenza B proton channel http://www.medworm.com/index.php?rid=3114522&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FMk903hBBG0k%2Fnsmb.1707 Authors: Junfeng Wang, Rafal M Pielak, Mark A McClintock & James J Chou (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114522 Sun, 08 Nov 2009 00:00:00 +0100 3114522 Nonspecifically bound proteins spin while diffusing along DNA http://www.medworm.com/index.php?rid=3114516&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FP6s4_o4Fdxc%2Fnsmb.1716 Authors: Paul C Blainey, Guobin Luo, S C Kou, Walter F Mangel, Gregory L Verdine, Biman Bagchi & X Sunney Xie (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114516 Sun, 08 Nov 2009 00:00:00 +0100 3114516 Structural basis of ligand binding by a c-di-GMP riboswitch http://www.medworm.com/index.php?rid=3114515&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F7Iq7iSWJ8T0%2Fnsmb.1702 Authors: Kathryn D Smith, Sarah V Lipchock, Tyler D Ames, Jimin Wang, Ronald R Breaker & Scott A Strobel (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114515 Sun, 08 Nov 2009 00:00:00 +0100 3114515 Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch http://www.medworm.com/index.php?rid=3114514&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FyEaaSM5xmoQ%2Fnsmb.1701 Authors: Nadia Kulshina, Nathan J Baird & Adrian R Ferré-D'Amaré (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114514 Sun, 08 Nov 2009 00:00:00 +0100 3114514 Structural insights into the mechanism of abscisic acid signaling by PYL proteins http://www.medworm.com/index.php?rid=3114517&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FjJDzZ8cb0gw%2Fnsmb.1730 Authors: Ping Yin, He Fan, Qi Hao, Xiaoqiu Yuan, Di Wu, Yuxuan Pang, Chuangye Yan, Wenqi Li, Jiawei Wang & Nieng Yan (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=3114517 Thu, 05 Nov 2009 00:00:00 +0100 3114517 Research highlights http://www.medworm.com/index.php?rid=2819035&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F6QXVhifFS48%2Fnsmb0909-909 Nature Structural & Molecular Biology 16, 909 (2009). doi:10.1038/nsmb0909-909 (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819035 Tue, 22 Sep 2009 17:57:23 +0100 2819035 Dangerous play—splitting the message may leave you empty handed http://www.medworm.com/index.php?rid=2819034&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FsTIrZtaBrjM%2Fnsmb0909-907 Dangerous play—splitting the message may leave you empty handed Nature Structural & Molecular Biology 16, 907 (2009). doi:10.1038/nsmb0909-907 Authors: Yvonne Klaue & Klemens J Hertel An important aspect of eukaryotic gene expression is the efficient integration of transcription, pre-mRNA processing and nuclear export. A new study demonstrates that pre-mRNA transcript continuity is an essential component for maintaining productive coupling of transcription and RNA processing events. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819034 Tue, 22 Sep 2009 17:57:23 +0100 2819034 New functions for an ancient domain http://www.medworm.com/index.php?rid=2819033&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FyvhfnJ7M5s0%2Fnsmb0909-904 Nature Structural & Molecular Biology 16, 904 (2009). doi:10.1038/nsmb0909-904 Author: W Lee Kraus Macrodomains function as binding modules for metabolites of NAD+, including poly(ADP-ribose). Three new studies explore how binding of poly(ADP-ribose) by the macrodomains of histone variant macroH2A1.1 and the ATP-dependent chromatin-remodeling protein ALC1 (also called CHD1L) leads to the modulation of chromatin structure, regulating nuclear functions such as DNA-damage detection and repair. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819033 Tue, 22 Sep 2009 17:57:23 +0100 2819033 When chromatin meets splicing http://www.medworm.com/index.php?rid=2819032&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fqbbng1LPZIk%2Fnsmb0909-902 Authors: Alberto R Kornblihtt, Ignacio E Schor, Mariano Allo & Benjamin J Blencowe Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819032 Tue, 22 Sep 2009 17:57:23 +0100 2819032 The p53 transcriptional synapse: activation on demand http://www.medworm.com/index.php?rid=2819031&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FepMEg0NBCG4%2Fnsmb0909-900 Authors: Genrich V Tolstonog & Wolfgang Deppert The adequate and on-time response of cellular transcription to internal needs and external stimuli is a delicate task. Is the transcriptional regulator p53 on call to permit rapid activation of its target genes? A new study reports interplay of p53 with a previously unidentified regulator, calcineurin-binding protein 1 (Cabin1), and provides evidence for such a mechanism. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819031 Tue, 22 Sep 2009 17:57:23 +0100 2819031 The unsung reviewer http://www.medworm.com/index.php?rid=2819030&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fh63x5bFaJZw%2Fnsmb0909-899 Nature Structural & Molecular Biology 16, 899 (2009). doi:10.1038/nsmb0909-899 Manuscript peer reviewing is at the heart of the scientific system, but it seems that these duties are often not properly (if at all) recognized by universities, funding agencies or even the rest of the scientific community. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819030 Tue, 22 Sep 2009 17:57:23 +0100 2819030 Research highlights http://www.medworm.com/index.php?rid=2761312&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0909-909 Nature Structural & Molecular Biology 16, 909 (2009). doi:10.1038/nsmb0909-909 (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761312 Thu, 03 Sep 2009 17:48:26 +0100 2761312 Dangerous play—splitting the message may leave you empty handed http://www.medworm.com/index.php?rid=2761311&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0909-907 Dangerous play—splitting the message may leave you empty handed Nature Structural & Molecular Biology 16, 907 (2009). doi:10.1038/nsmb0909-907 Authors: Yvonne Klaue & Klemens J Hertel An important aspect of eukaryotic gene expression is the efficient integration of transcription, pre-mRNA processing and nuclear export. A new study demonstrates that pre-mRNA transcript continuity is an essential component for maintaining productive coupling of transcription and RNA processing events. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761311 Thu, 03 Sep 2009 17:48:26 +0100 2761311 New functions for an ancient domain http://www.medworm.com/index.php?rid=2761310&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0909-904 Nature Structural & Molecular Biology 16, 904 (2009). doi:10.1038/nsmb0909-904 Author: W Lee Kraus Macrodomains function as binding modules for metabolites of NAD+, including poly(ADP-ribose). Three new studies explore how binding of poly(ADP-ribose) by the macrodomains of histone variant macroH2A1.1 and the ATP-dependent chromatin-remodeling protein ALC1 (also called CHD1L) leads to the modulation of chromatin structure, regulating nuclear functions such as DNA-damage detection and repair. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761310 Thu, 03 Sep 2009 17:48:26 +0100 2761310 When chromatin meets splicing http://www.medworm.com/index.php?rid=2761309&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0909-902 Authors: Alberto R Kornblihtt, Ignacio E Schor, Mariano Allo & Benjamin J Blencowe Using bioinformatics analysis of previously published global genome deep-sequencing data, two papers now show that DNA sequences associated with nucleosomes are preferentially located in exons. The correlation between nucleosome distribution and the exon-intron organization of genes may have a key role in exon recognition at the pre-mRNA level during co-transcriptional splicing, consistent with previous findings indicating chromatin-mediated regulation of alternative splicing. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761309 Thu, 03 Sep 2009 17:48:26 +0100 2761309 The p53 transcriptional synapse: activation on demand http://www.medworm.com/index.php?rid=2761308&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0909-900 Authors: Genrich V Tolstonog & Wolfgang Deppert The adequate and on-time response of cellular transcription to internal needs and external stimuli is a delicate task. Is the transcriptional regulator p53 on call to permit rapid activation of its target genes? A new study reports interplay of p53 with a previously unidentified regulator, calcineurin-binding protein 1 (Cabin1), and provides evidence for such a mechanism. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761308 Thu, 03 Sep 2009 17:48:26 +0100 2761308 The unsung reviewer http://www.medworm.com/index.php?rid=2761307&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0909-899 Nature Structural & Molecular Biology 16, 899 (2009). doi:10.1038/nsmb0909-899 Manuscript peer reviewing is at the heart of the scientific system, but it seems that these duties are often not properly (if at all) recognized by universities, funding agencies or even the rest of the scientific community. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761307 Thu, 03 Sep 2009 17:48:26 +0100 2761307 Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ http://www.medworm.com/index.php?rid=2819046&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FceWb2YIZBYs%2Fnsmb.1663 Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ Nature Structural & Molecular Biology 16, 979 (2009). doi:10.1038/nsmb.1663 Authors: Michael K Swan, Robert E Johnson, Louise Prakash, Satya Prakash & Aneel K Aggarwal (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819046 Sat, 29 Aug 2009 23:00:00 +0100 2819046 Template strand scrunching during DNA gap repair synthesis by human polymerase λ http://www.medworm.com/index.php?rid=2819044&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FcvSiitfrUKs%2Fnsmb.1654 Template strand scrunching during DNA gap repair synthesis by human polymerase λ Nature Structural & Molecular Biology 16, 967 (2009). doi:10.1038/nsmb.1654 Authors: Miguel Garcia-Diaz, Katarzyna Bebenek, Andres A Larrea, Jody M Havener, Lalith Perera, Joseph M Krahn, Lars C Pedersen, Dale A Ramsden & Thomas A Kunkel (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819044 Sat, 22 Aug 2009 23:00:00 +0100 2819044 Dynamics and function of compact nucleosome arrays http://www.medworm.com/index.php?rid=2819040&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FLinyYF9r3r8%2Fnsmb.1650 Authors: Michael G Poirier, Eugene Oh, Hannah S Tims & Jonathan Widom (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819040 Sat, 22 Aug 2009 23:00:00 +0100 2819040 Fast ribozyme cleavage releases transcripts from RNA polymerase II and aborts co-transcriptional pre-mRNA processing http://www.medworm.com/index.php?rid=2819037&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FzqH0fXMe-ws%2Fnsmb.1652 Authors: Nova Fong, Marie Öhman & David L Bentley (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819037 Sat, 22 Aug 2009 23:00:00 +0100 2819037 Template strand scrunching during DNA gap repair synthesis by human polymerase λ http://www.medworm.com/index.php?rid=2761321&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1654 Template strand scrunching during DNA gap repair synthesis by human polymerase λ Nature Structural & Molecular Biology 16, 967 (2009). doi:10.1038/nsmb.1654 Authors: Miguel Garcia-Diaz, Katarzyna Bebenek, Andres A Larrea, Jody M Havener, Lalith Perera, Joseph M Krahn, Lars C Pedersen, Dale A Ramsden & Thomas A Kunkel (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761321 Sat, 22 Aug 2009 23:00:00 +0100 2761321 Dynamics and function of compact nucleosome arrays http://www.medworm.com/index.php?rid=2761317&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1650 Authors: Michael G Poirier, Eugene Oh, Hannah S Tims & Jonathan Widom (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761317 Sat, 22 Aug 2009 23:00:00 +0100 2761317 Fast ribozyme cleavage releases transcripts from RNA polymerase II and aborts co-transcriptional pre-mRNA processing http://www.medworm.com/index.php?rid=2761314&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1652 Authors: Nova Fong, Marie Öhman & David L Bentley (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761314 Sat, 22 Aug 2009 23:00:00 +0100 2761314 Nucleosome positioning as a determinant of exon recognition http://www.medworm.com/index.php?rid=2819049&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FV2OGh8hcia0%2Fnsmb.1658 Authors: Hagen Tilgner, Christoforos Nikolaou, Sonja Althammer, Michael Sammeth, Miguel Beato, Juan Valcárcel & Roderic Guigó (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819049 Sat, 15 Aug 2009 23:00:00 +0100 2819049 Chromatin organization marks exon-intron structure http://www.medworm.com/index.php?rid=2819048&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fl84P-FAoHxk%2Fnsmb.1659 Authors: Schraga Schwartz, Eran Meshorer & Gil Ast (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819048 Sat, 15 Aug 2009 23:00:00 +0100 2819048 Molecular mechanisms for protein-encoded inheritance http://www.medworm.com/index.php?rid=2819045&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2Fri9qTQ267gM%2Fnsmb.1643 Authors: Jed J W Wiltzius, Meytal Landau, Rebecca Nelson, Michael R Sawaya, Marcin I Apostol, Lukasz Goldschmidt, Angela B Soriaga, Duilio Cascio, Kanagalaghatta Rajashankar & David Eisenberg (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819045 Sat, 15 Aug 2009 23:00:00 +0100 2819045 Structural determinants of miRNAs for RISC loading and slicer-independent unwinding http://www.medworm.com/index.php?rid=2819042&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FrnyR9kCh7nE%2Fnsmb.1630 Authors: Tomoko Kawamata, Hervé Seitz & Yukihide Tomari (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819042 Sat, 15 Aug 2009 23:00:00 +0100 2819042 A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9 http://www.medworm.com/index.php?rid=2819041&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FJaAOeUQoUTk%2Fnsmb.1648 Authors: Firaz Mohideen, Allan D Capili, Parizad M Bilimoria, Tomoko Yamada, Azad Bonni & Christopher D Lima (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819041 Sat, 15 Aug 2009 23:00:00 +0100 2819041 Nucleosome positioning as a determinant of exon recognition http://www.medworm.com/index.php?rid=2761326&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1658 Authors: Hagen Tilgner, Christoforos Nikolaou, Sonja Althammer, Michael Sammeth, Miguel Beato, Juan Valcárcel & Roderic Guigó (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761326 Sat, 15 Aug 2009 23:00:00 +0100 2761326 Chromatin organization marks exon-intron structure http://www.medworm.com/index.php?rid=2761325&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1659 Authors: Schraga Schwartz, Eran Meshorer & Gil Ast (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761325 Sat, 15 Aug 2009 23:00:00 +0100 2761325 Molecular mechanisms for protein-encoded inheritance http://www.medworm.com/index.php?rid=2761322&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1643 Authors: Jed J W Wiltzius, Meytal Landau, Rebecca Nelson, Michael R Sawaya, Marcin I Apostol, Lukasz Goldschmidt, Angela B Soriaga, Duilio Cascio, Kanagalaghatta Rajashankar & David Eisenberg (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761322 Sat, 15 Aug 2009 23:00:00 +0100 2761322 Structural determinants of miRNAs for RISC loading and slicer-independent unwinding http://www.medworm.com/index.php?rid=2761319&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1630 Authors: Tomoko Kawamata, Hervé Seitz & Yukihide Tomari (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761319 Sat, 15 Aug 2009 23:00:00 +0100 2761319 A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9 http://www.medworm.com/index.php?rid=2761318&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1648 Authors: Firaz Mohideen, Allan D Capili, Parizad M Bilimoria, Tomoko Yamada, Azad Bonni & Christopher D Lima (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761318 Sat, 15 Aug 2009 23:00:00 +0100 2761318 A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation http://www.medworm.com/index.php?rid=2819038&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2F0SsKULZ9TOg%2Fnsmb.1664 Authors: Gyula Timinszky, Susanne Till, Paul O Hassa, Michael Hothorn, Georg Kustatscher, Bianca Nijmeijer, Julien Colombelli, Matthias Altmeyer, Ernst H K Stelzer, Klaus Scheffzek, Michael O Hottiger & Andreas G Ladurner (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819038 Wed, 12 Aug 2009 23:00:00 +0100 2819038 A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation http://www.medworm.com/index.php?rid=2761315&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1664 Authors: Gyula Timinszky, Susanne Till, Paul O Hassa, Michael Hothorn, Georg Kustatscher, Bianca Nijmeijer, Julien Colombelli, Matthias Altmeyer, Ernst H K Stelzer, Klaus Scheffzek, Michael O Hottiger & Andreas G Ladurner (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761315 Wed, 12 Aug 2009 23:00:00 +0100 2761315 Insights into anaphase promoting complex TPR subdomain assembly from a CDC26–APC6 structure http://www.medworm.com/index.php?rid=2819047&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FGK9FUMJCcgs%2Fnsmb.1645 Insights into anaphase promoting complex TPR subdomain assembly from a CDC26–APC6 structure Nature Structural & Molecular Biology 16, 987 (2009). doi:10.1038/nsmb.1645 Authors: Jing Wang, Billy T Dye, Kanagalaghatta R Rajashankar, Igor Kurinov & Brenda A Schulman The multisubunit anaphase promoting complex (APC) is an essential cell-cycle regulator. Although CDC26 is known to have a role in APC assembly, its molecular function has remained unclear. Biophysical, structural and genetic studies presented here reveal that CDC26 stabilizes the structure of APC6, a core TPR protein required for APC integrity. Notably, CDC26–APC6 association involves an intermolecular TPR mimic composed of one helix from each protein. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819047 Sat, 08 Aug 2009 23:00:00 +0100 2819047 Existence of a microRNA pathway in anucleate platelets http://www.medworm.com/index.php?rid=2819043&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FEqmASq63e5I%2Fnsmb.1651 Authors: Patricia Landry, Isabelle Plante, Dominique L Ouellet, Marjorie P Perron, Guy Rousseau & Patrick Provost (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819043 Sat, 08 Aug 2009 23:00:00 +0100 2819043 The molecular basis for the regulation of the cap-binding complex by the importins http://www.medworm.com/index.php?rid=2819039&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FlVQiNA7XQEQ%2Fnsmb.1649 Authors: Sandra M G Dias, Kristin F Wilson, Katherine S Rojas, Andre L B Ambrosio & Richard A Cerione (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819039 Sat, 08 Aug 2009 23:00:00 +0100 2819039 Cabin1 restrains p53 activity on chromatin http://www.medworm.com/index.php?rid=2819036&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Ffeeds.nature.com%2F%7Er%2Fnsmb%2Frss%2Fcurrent%2F%7E3%2FyrEnAM97SXE%2Fnsmb.1657 Authors: Hyonchol Jang, Soo-Youn Choi, Eun-Jung Cho & Hong-Duk Youn (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2819036 Sat, 08 Aug 2009 23:00:00 +0100 2819036 Insights into anaphase promoting complex TPR subdomain assembly from a CDC26–APC6 structure http://www.medworm.com/index.php?rid=2761324&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1645 Insights into anaphase promoting complex TPR subdomain assembly from a CDC26–APC6 structure Nature Structural & Molecular Biology 16, 987 (2009). doi:10.1038/nsmb.1645 Authors: Jing Wang, Billy T Dye, Kanagalaghatta R Rajashankar, Igor Kurinov & Brenda A Schulman The multisubunit anaphase promoting complex (APC) is an essential cell-cycle regulator. Although CDC26 is known to have a role in APC assembly, its molecular function has remained unclear. Biophysical, structural and genetic studies presented here reveal that CDC26 stabilizes the structure of APC6, a core TPR protein required for APC integrity. Notably, CDC26–APC6 association involves an intermolecular TPR mimic composed of one helix from each protein. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761324 Sat, 08 Aug 2009 23:00:00 +0100 2761324 Existence of a microRNA pathway in anucleate platelets http://www.medworm.com/index.php?rid=2761320&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1651 Authors: Patricia Landry, Isabelle Plante, Dominique L Ouellet, Marjorie P Perron, Guy Rousseau & Patrick Provost (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761320 Sat, 08 Aug 2009 23:00:00 +0100 2761320 The molecular basis for the regulation of the cap-binding complex by the importins http://www.medworm.com/index.php?rid=2761316&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1649 Authors: Sandra M G Dias, Kristin F Wilson, Katherine S Rojas, Andre L B Ambrosio & Richard A Cerione (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761316 Sat, 08 Aug 2009 23:00:00 +0100 2761316 Cabin1 restrains p53 activity on chromatin http://www.medworm.com/index.php?rid=2761313&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1657 Authors: Hyonchol Jang, Soo-Youn Choi, Eun-Jung Cho & Hong-Duk Youn (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2761313 Sat, 08 Aug 2009 23:00:00 +0100 2761313 Erratum: The nucleotide binding dynamics of human MSH2–MSH3 are lesion dependent http://www.medworm.com/index.php?rid=2670461&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0809-897a Erratum: The nucleotide binding dynamics of human MSH2–MSH3 are lesion dependent Nature Structural & Molecular Biology 16, 897 (2009). doi:10.1038/nsmb0809-897a Author: Barbara A L Owen, Walter H Lang & Cynthia T McMurray (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670461 Wed, 05 Aug 2009 12:15:12 +0100 2670461 Corrigendum: Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout http://www.medworm.com/index.php?rid=2670460&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0809-897b Nature Structural & Molecular Biology 16, 897 (2009). doi:10.1038/nsmb0809-897b Author: Julie L Hodgkinson, Ashley Horsley, David Stabat, Martha Simon, Steven Johnson, Paula C A da Fonseca, Edward P Morris, Joseph S Wall, Susan M Lea & Ariel J Blocker (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670460 Wed, 05 Aug 2009 12:15:12 +0100 2670460 Research highlights http://www.medworm.com/index.php?rid=2670446&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0809-807 Nature Structural & Molecular Biology 16, 807 (2009). doi:10.1038/nsmb0809-807 (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670446 Wed, 05 Aug 2009 12:15:12 +0100 2670446 Kill the messenger: bacterial antisense RNA promotes mRNA decay http://www.medworm.com/index.php?rid=2670445&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0809-804 Nature Structural & Molecular Biology 16, 804 (2009). doi:10.1038/nsmb0809-804 Author: E Gerhart H Wagner Bacterial antisense RNAs target translation initiation regions (TIRs) to compete with ribosome binding, thus repressing translation and—secondarily—causing degradation of the naked mRNA. A new study reports on an antisense RNA that directly accelerates mRNA decay by targeting a sequence deep within the coding region, far downstream of the TIR. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670445 Wed, 05 Aug 2009 12:15:12 +0100 2670445 Grb-ing hold of insulin signaling http://www.medworm.com/index.php?rid=2670444&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0809-803 Authors: Derek F J Ceccarelli & Frank Sicheri It is just as important to shut off a signaling pathway as it is to turn it on. A new study on the tandem Ras-associating (RA) and pleckstrin-homology (PH) domains of Grb10 and Grb14 provides important insight into a multicomponent assembly for downregulating insulin receptor signaling. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670444 Wed, 05 Aug 2009 12:15:12 +0100 2670444 Hit and run: X marks the spot! http://www.medworm.com/index.php?rid=2670443&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0809-801 Authors: Vikki M Weake & Jerry L Workman Male fruitflies upregulate transcription of nearly all genes on their single X chromosome to equalize expression with the two X chromosomes in females. A new study shows that the distribution of the histone acetylation mark associated with this upregulation is much broader than that of the MSL complex responsible for depositing this mark. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670443 Wed, 05 Aug 2009 12:15:12 +0100 2670443 Mre11: roles in DNA repair beyond homologous recombination http://www.medworm.com/index.php?rid=2670442&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0809-798 Authors: Shan Zha, Cristian Boboila & Frederick W Alt The Mre11 protein has well-documented functions in the repair of DNA double-strand breaks via homologous recombination. Now, several new studies reveal that Mre11 also has a role in mammalian DNA double-strand break repair by nonhomologous end joining. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670442 Wed, 05 Aug 2009 12:15:12 +0100 2670442 A different perspective on science http://www.medworm.com/index.php?rid=2670441&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0809-797 Nature Structural & Molecular Biology 16, 797 (2009). doi:10.1038/nsmb0809-797 A recent survey revealed striking differences between the public and scientists' views of US scientific achievement and its societal benefits. This reinforces the fact that more must be done to effectively communicate with, educate and engage the public. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670441 Wed, 05 Aug 2009 12:15:12 +0100 2670441 Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14 http://www.medworm.com/index.php?rid=2670451&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1642 Authors: Rafael S Depetris, Jinhua Wu & Stevan R Hubbard (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670451 Sat, 01 Aug 2009 23:00:00 +0100 2670451 Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation http://www.medworm.com/index.php?rid=2670450&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1644 Authors: Marnie E Gelbart, Erica Larschan, Shouyong Peng, Peter J Park & Mitzi I Kuroda (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670450 Sat, 01 Aug 2009 23:00:00 +0100 2670450 Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells http://www.medworm.com/index.php?rid=2670449&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1641 Authors: Emilie Rass, Anastazja Grabarz, Isabelle Plo, Jean Gautier, Pascale Bertrand & Bernard S Lopez (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670449 Sat, 25 Jul 2009 23:00:00 +0100 2670449 Role of mammalian Mre11 in classical and alternative nonhomologous end joining http://www.medworm.com/index.php?rid=2670448&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1640 Authors: Anyong Xie, Amy Kwok & Ralph Scully (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670448 Sat, 25 Jul 2009 23:00:00 +0100 2670448 Multiple functions of MRN in end-joining pathways during isotype class switching http://www.medworm.com/index.php?rid=2670447&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1639 Authors: Maria Dinkelmann, Elizabeth Spehalski, Trina Stoneham, Jeffrey Buis, Yipin Wu, JoAnn M Sekiguchi & David O Ferguson (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670447 Sat, 25 Jul 2009 23:00:00 +0100 2670447 Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domains http://www.medworm.com/index.php?rid=2670458&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1637 Authors: Joshua J Sims, Aydin Haririnia, Bryan C Dickinson, David Fushman & Robert E Cohen (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670458 Sun, 19 Jul 2009 23:00:00 +0100 2670458 Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics http://www.medworm.com/index.php?rid=2670454&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1647 Authors: Zhiwei Huang, Sarah E Sutton, Adam J Wallenfang, Robert C Orchard, Xiaojing Wu, Yingcai Feng, Jijie Chai & Neal M Alto (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670454 Sun, 19 Jul 2009 23:00:00 +0100 2670454 Intrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo http://www.medworm.com/index.php?rid=2670453&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1636 Authors: Yong Zhang, Zarmik Moqtaderi, Barbara P Rattner, Ghia Euskirchen, Michael Snyder, James T Kadonaga, X Shirley Liu & Kevin Struhl (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670453 Sun, 19 Jul 2009 23:00:00 +0100 2670453 Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation http://www.medworm.com/index.php?rid=2670452&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1631 Authors: Verena Pfeiffer, Kai Papenfort, Sacha Lucchini, Jay C D Hinton & Jörg Vogel (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670452 Sun, 19 Jul 2009 23:00:00 +0100 2670452 Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy http://www.medworm.com/index.php?rid=2670459&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1627 Authors: Raul Perez-Jimenez, Jingyuan Li, Pallav Kosuri, Inmaculada Sanchez-Romero, Arun P Wiita, David Rodriguez-Larrea, Ana Chueca, Arne Holmgren, Antonio Miranda-Vizuete, Katja Becker, Seung-Hyun Cho, Jon Beckwith, Eric Gelhaye, Jean P Jacquot, Eric Gaucher, Jose M Sanchez-Ruiz, Bruce J Berne & Julio M Fernandez (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670459 Sun, 12 Jul 2009 23:00:00 +0100 2670459 Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1 http://www.medworm.com/index.php?rid=2670457&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1628 Authors: Sang-Moon Yun, Tinoush Moulaei, Dan Lim, Jeong K Bang, Jung-Eun Park, Shilpa R Shenoy, Fa Liu, Young H Kang, Chenzhong Liao, Nak-Kyun Soung, Sunhee Lee, Do-Young Yoon, Yoongho Lim, Dong-Hee Lee, Akira Otaka, Ettore Appella, James B McMahon, Marc C Nicklaus, Terrence R Burke Jr, Michael B Yaffe, Alexander Wlodawer & Kyung S Lee (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670457 Sun, 12 Jul 2009 23:00:00 +0100 2670457 Incision-dependent and error-free repair of (CAG)n/(CTG)n hairpins in human cell extracts http://www.medworm.com/index.php?rid=2670456&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1638 Authors: Caixia Hou, Nelson L S Chan, Liya Gu & Guo-Min Li (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670456 Sun, 12 Jul 2009 23:00:00 +0100 2670456 Translation factors direct intrinsic ribosome dynamics during translation termination and ribosome recycling http://www.medworm.com/index.php?rid=2670455&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1622 Authors: Samuel H Sternberg, Jingyi Fei, Noam Prywes, Kelly A McGrath & Ruben L Gonzalez (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2670455 Sun, 12 Jul 2009 23:00:00 +0100 2670455 Retraction: Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 Å resolution http://www.medworm.com/index.php?rid=2572745&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0709-795 Retraction: Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 Å resolution Nature Structural & Molecular Biology 16, 795 (2009). doi:10.1038/nsmb0709-795 Authors: Michael A Hanson & Raymond C Stevens (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572745 Mon, 06 Jul 2009 11:58:36 +0100 2572745 Research highlights http://www.medworm.com/index.php?rid=2572728&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0709-683 Nature Structural & Molecular Biology 16, 683 (2009). doi:10.1038/nsmb0709-683 (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572728 Mon, 06 Jul 2009 11:58:36 +0100 2572728 Energetics of protein hydrogen bonds http://www.medworm.com/index.php?rid=2572727&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0709-681 Nature Structural & Molecular Biology 16, 681 (2009). doi:10.1038/nsmb0709-681 Author: C Nick Pace In this issue, an article gives insight into the microenvironment's influence on the contribution of hydrogen bonds to protein stability. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572727 Mon, 06 Jul 2009 11:58:36 +0100 2572727 WDR5, a complexed protein http://www.medworm.com/index.php?rid=2572726&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0709-678 Authors: Raymond C Trievel & Ali Shilatifard The WD40 protein WDR5 is a core subunit of the human MLL and SET1 (hCOMPASS) histone H3 Lys4 (H3K4) methyltransferase complexes. Although initial studies suggested that WDR5 interacts with methylated H3K4 to catalyze Lys4 trimethylation, recent work has revealed that it binds an arginine-bearing motif in MLL1, promoting complex assembly and activity. These findings suggest that WDR5 functions as a peptidyl arginine–recognition factor that facilitates the assembly of hCOMPASS and other chromatin-modifying complexes. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572726 Mon, 06 Jul 2009 11:58:36 +0100 2572726 Welcoming the best and the brightest from everywhere http://www.medworm.com/index.php?rid=2572725&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0709-677 Nature Structural & Molecular Biology 16, 677 (2009). doi:10.1038/nsmb0709-677 The US State Department promises to accelerate the visa process for foreign graduate students and postdoctoral researchers. That will be a welcome change. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572725 Mon, 06 Jul 2009 11:58:36 +0100 2572725 H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming http://www.medworm.com/index.php?rid=2572742&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1629 Authors: Sylvain Daujat, Thomas Weiss, Fabio Mohn, Ulrike C Lange, Céline Ziegler-Birling, Ulrike Zeissler, Michael Lappe, Dirk Schübeler, Maria-Elena Torres-Padilla & Robert Schneider (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572742 Sat, 27 Jun 2009 23:00:00 +0100 2572742 Structural determinants of gating in the TRPV1 channel http://www.medworm.com/index.php?rid=2572732&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1633 Authors: Héctor Salazar, Andrés Jara-Oseguera, Enrique Hernández-García, Itzel Llorente, Imilla I Arias-Olguín, Manuel Soriano-García, León D Islas & Tamara Rosenbaum (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572732 Sat, 27 Jun 2009 23:00:00 +0100 2572732 Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP http://www.medworm.com/index.php?rid=2572731&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1607 Authors: Benjamin Bishop, A Radu Aricescu, Karl Harlos, Chris A O'Callaghan, E Yvonne Jones & Christian Siebold (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572731 Sat, 27 Jun 2009 23:00:00 +0100 2572731 The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling http://www.medworm.com/index.php?rid=2572730&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1632 Authors: Ivan Bosanac, Henry R Maun, Suzie J Scales, Xiaohui Wen, Andreas Lingel, J Fernando Bazan, Frederic J de Sauvage, Sarah G Hymowitz & Robert A Lazarus (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572730 Sat, 27 Jun 2009 23:00:00 +0100 2572730 Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F http://www.medworm.com/index.php?rid=2572744&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1626 Authors: Rakhi Agarwal, James J Schmidt, Robert G Stafford & Subramanyam Swaminathan (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572744 Sat, 20 Jun 2009 23:00:00 +0100 2572744 AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity http://www.medworm.com/index.php?rid=2572741&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1623 Authors: Meng Wang, Zizhen Yang, Cristina Rada & Michael S Neuberger (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572741 Sat, 20 Jun 2009 23:00:00 +0100 2572741 Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen http://www.medworm.com/index.php?rid=2572735&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1619 Authors: C Alejandro Velikovsky, Lu Deng, Satoshi Tasumi, Lakshminarayan M Iyer, Melissa C Kerzic, L Aravind, Zeev Pancer & Roy A Mariuzza (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572735 Sat, 20 Jun 2009 23:00:00 +0100 2572735 Control of alternative splicing through siRNA-mediated transcriptional gene silencing http://www.medworm.com/index.php?rid=2572734&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1620 Authors: Mariano Alló, Valeria Buggiano, Juan P Fededa, Ezequiel Petrillo, Ignacio Schor, Manuel de la Mata, Eneritz Agirre, Mireya Plass, Eduardo Eyras, Sherif Abou Elela, Roscoe Klinck, Benoit Chabot & Alberto R Kornblihtt (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572734 Sat, 20 Jun 2009 23:00:00 +0100 2572734 Structural basis for ESCRT-III protein autoinhibition http://www.medworm.com/index.php?rid=2572739&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1621 Authors: Monika Bajorek, Heidi L Schubert, John McCullough, Charles Langelier, Debra M Eckert, William-May B Stubblefield, Nathan T Uter, David G Myszka, Christopher P Hill & Wesley I Sundquist (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572739 Sat, 13 Jun 2009 23:00:00 +0100 2572739 Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2 http://www.medworm.com/index.php?rid=2572736&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1625 Authors: Lingdi Zhang, Tao Xu, Corina Maeder, Laura-Oana Bud, James Shanks, Jay Nix, Christine Guthrie, Jeffrey A Pleiss & Rui Zhao (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572736 Sat, 13 Jun 2009 23:00:00 +0100 2572736 The Hsp82 molecular chaperone promotes a switch between unextendable and extendable telomere states http://www.medworm.com/index.php?rid=2572733&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1616 Authors: Diane C DeZwaan, Oyetunji A Toogun, Frank J Echtenkamp & Brian C Freeman (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572733 Sat, 13 Jun 2009 23:00:00 +0100 2572733 Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins http://www.medworm.com/index.php?rid=2572729&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1610 Authors: Jianmin Gao, Daryl A Bosco, Evan T Powers & Jeffery W Kelly (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572729 Sat, 13 Jun 2009 23:00:00 +0100 2572729 Three-dimensional structure and flexibility of a membrane-coating module of the nuclear pore complex http://www.medworm.com/index.php?rid=2572743&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1618 Authors: Martin Kampmann & Günter Blobel (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572743 Sat, 06 Jun 2009 23:00:00 +0100 2572743 ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing http://www.medworm.com/index.php?rid=2572740&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1611 Authors: Yannick Jacob, Suhua Feng, Chantal A LeBlanc, Yana V Bernatavichute, Hume Stroud, Shawn Cokus, Lianna M Johnson, Matteo Pellegrini, Steven E Jacobsen & Scott D Michaels (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572740 Sat, 06 Jun 2009 23:00:00 +0100 2572740 A UPF3-mediated regulatory switch that maintains RNA surveillance http://www.medworm.com/index.php?rid=2572738&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1612 Authors: Wai-Kin Chan, Angela D Bhalla, Hervé Le Hir, Lam Son Nguyen, Lulu Huang, Jozef Gécz & Miles F Wilkinson (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572738 Sat, 06 Jun 2009 23:00:00 +0100 2572738 Research highlights http://www.medworm.com/index.php?rid=2456129&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0609-615 Nature Structural & Molecular Biology 16, 615 (2009). doi:10.1038/nsmb0609-615 (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456129 Sat, 06 Jun 2009 00:49:38 +0100 2456129 Activating apoptosis http://www.medworm.com/index.php?rid=2456128&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0609-614 Nature Structural & Molecular Biology 16, 614 (2009). doi:10.1038/nsmb0609-614 Author: Sabbi Lall (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456128 Sat, 06 Jun 2009 00:49:38 +0100 2456128 A new way to initiate mRNA degradation http://www.medworm.com/index.php?rid=2456127&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0609-613 Nature Structural & Molecular Biology 16, 613 (2009). doi:10.1038/nsmb0609-613 Author: William Marzluff Removal of the poly(A) tail is the initial step in targeting an mRNA for degradation in budding yeast as well as in metazoans. But in fission yeast a new study reveals an additional pathway that adds uridines to the poly(A) tail of mRNA to initiate the degradation pathway. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456127 Sat, 06 Jun 2009 00:49:38 +0100 2456127 Folding to function http://www.medworm.com/index.php?rid=2456121&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0609-573 Nature Structural & Molecular Biology 16, 573 (2009). doi:10.1038/nsmb0609-573 The practice of origami dates from the 1600s, but this cannot compare to how long proteins have been evolving form and function. How proteins achieve their correct shape is the subject of this special Focus. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456121 Sat, 06 Jun 2009 00:49:38 +0100 2456121 Cellular mechanisms of membrane protein folding http://www.medworm.com/index.php?rid=2456126&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1600 Nature Structural & Molecular Biology 16, 606 (2009). doi:10.1038/nsmb.1600 Author: William R Skach (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456126 Wed, 03 Jun 2009 04:00:00 +0100 2456126 Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+] http://www.medworm.com/index.php?rid=2456125&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1617 Authors: Peter M. Tessier & Susan Lindquist (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456125 Wed, 03 Jun 2009 04:00:00 +0100 2456125 The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins http://www.medworm.com/index.php?rid=2456124&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1614 Authors: Günter Kramer, Daniel Boehringer, Nenad Ban & Bernd Bukau (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456124 Wed, 03 Jun 2009 04:00:00 +0100 2456124 An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms http://www.medworm.com/index.php?rid=2456123&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1592 Authors: Alice I Bartlett & Sheena E Radford (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456123 Wed, 03 Jun 2009 04:00:00 +0100 2456123 Converging concepts of protein folding in vitro and in vivo http://www.medworm.com/index.php?rid=2456122&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1591 Authors: F Ulrich Hartl & Manajit Hayer-Hartl (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456122 Wed, 03 Jun 2009 04:00:00 +0100 2456122 Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA http://www.medworm.com/index.php?rid=2572737&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1624 Authors: Bo Liang, Jing Zhou, Elliot Kahen, Rebecca M Terns, Michael P Terns & Hong Li (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2572737 Wed, 27 May 2009 23:00:00 +0100 2572737 E2 interaction and dimerization in the crystal structure of TRAF6 http://www.medworm.com/index.php?rid=2456136&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1605 Authors: Qian Yin, Su-Chang Lin, Betty Lamothe, Miao Lu, Yu-Chih Lo, Gregory Hura, Lixin Zheng, Rebecca L Rich, Alejandro D Campos, David G Myszka, Michael J Lenardo, Bryant G Darnay & Hao Wu (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456136 Sun, 24 May 2009 04:00:00 +0100 2456136 Loss of the Mili-interacting Tudor domain–containing protein-1 activates transposons and alters the Mili-associated small RNA profile http://www.medworm.com/index.php?rid=2456133&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1615 Loss of the Mili-interacting Tudor domain–containing protein-1 activates transposons and alters the Mili-associated small RNA profile Nature Structural & Molecular Biology 16, 639 (2009). doi:10.1038/nsmb.1615 Authors: Michael Reuter, Shinichiro Chuma, Takashi Tanaka, Thomas Franz, Alexander Stark & Ramesh S Pillai (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456133 Sun, 24 May 2009 04:00:00 +0100 2456133 The N-terminal domain of GluR6-subtype glutamate receptor ion channels http://www.medworm.com/index.php?rid=2456132&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1613 Authors: Janesh Kumar, Peter Schuck, Rongsheng Jin & Mark L Mayer (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456132 Sun, 24 May 2009 04:00:00 +0100 2456132 PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity http://www.medworm.com/index.php?rid=2456131&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1606 Authors: Angus J M Cameron, Cristina Escribano, Adrian T Saurin, Brenda Kostelecky & Peter J Parker (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456131 Sun, 24 May 2009 04:00:00 +0100 2456131 Cancer-associated regulation of alternative splicing http://www.medworm.com/index.php?rid=2456138&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1608 Authors: Julian P Venables, Roscoe Klinck, ChuShin Koh, Julien Gervais-Bird, Anne Bramard, Lyna Inkel, Mathieu Durand, Sonia Couture, Ulrike Froehlich, Elvy Lapointe, Jean-François Lucier, Philippe Thibault, Claudine Rancourt, Karine Tremblay, Panagiotis Prinos, Benoit Chabot & Sherif Abou Elela (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456138 Sun, 17 May 2009 04:00:00 +0100 2456138 Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases http://www.medworm.com/index.php?rid=2456137&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1604 We present the structures of cleavage complexes formed by the Streptococcus pneumoniae ParC breakage-reunion and ParE TOPRIM domains of topoisomerase IV stabilized by moxifloxacin and clinafloxacin, two antipneumococcal fluoroquinolones. These structures reveal two drug molecules intercalated at the highly bent DNA gate and help explain antibacterial quinolone action and resistance. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456137 Sun, 17 May 2009 04:00:00 +0100 2456137 Bacterial ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymes http://www.medworm.com/index.php?rid=2456134&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1597 Authors: Frank Striebel, Frank Imkamp, Markus Sutter, Martina Steiner, Azad Mamedov & Eilika Weber-Ban (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456134 Sun, 17 May 2009 04:00:00 +0100 2456134 Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures http://www.medworm.com/index.php?rid=2456135&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1602 Antidepressant specificity of serotonin transporter suggested by three LeuT–SSRI structures Nature Structural & Molecular Biology 16, 652 (2009). doi:10.1038/nsmb.1602 Authors: Zheng Zhou, Juan Zhen, Nathan K Karpowich, Christopher J Law, Maarten E A Reith & Da-Neng Wang (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456135 Sun, 10 May 2009 04:00:00 +0100 2456135 Decapping is preceded by 3′ uridylation in a novel pathway of bulk mRNA turnover http://www.medworm.com/index.php?rid=2456130&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1601 Decapping is preceded by 3′ uridylation in a novel pathway of bulk mRNA turnover Nature Structural & Molecular Biology 16, 616 (2009). doi:10.1038/nsmb.1601 Authors: Olivia S Rissland & Chris J Norbury (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2456130 Sun, 10 May 2009 04:00:00 +0100 2456130 Research highlights http://www.medworm.com/index.php?rid=2396879&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0509-461 Nature Structural & Molecular Biology 16, 461 (2009). doi:10.1038/nsmb0509-461 (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396879 Fri, 08 May 2009 02:30:05 +0100 2396879 Locavore science http://www.medworm.com/index.php?rid=2396878&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0509-453 Nature Structural & Molecular Biology 16, 453 (2009). doi:10.1038/nsmb0509-453 As we set off into the full swing of traveling for the globally oriented meeting season, it's worth also remembering the delights of local science consumption. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396878 Fri, 08 May 2009 02:30:05 +0100 2396878 Going round in circles: the structural biology of type III secretion systems http://www.medworm.com/index.php?rid=2396877&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0509-459 Nature Structural & Molecular Biology 16, 459 (2009). doi:10.1038/nsmb0509-459 Author: Gabriel Waksman Type III secretions systems (T3SSs) are major bacterial virulence factors responsible for secretion and injection of protein effectors into host cells. New structures illuminate their ring structure and identify novel ring-mediating structural scaffolds. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396877 Fri, 08 May 2009 02:30:05 +0100 2396877 Reply to “Mechanisms of APOBEC3G-catalyzed processive deamination of deoxycytidine on single-stranded DNA” http://www.medworm.com/index.php?rid=2396875&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0509-455 Reply to “Mechanisms of APOBEC3G-catalyzed processive deamination of deoxycytidine on single-stranded DNA” Nature Structural & Molecular Biology 16, 455 (2009). doi:10.1038/nsmb0509-455 Authors: Roni Nowarski, Elena Britan-Rosich & Moshe Kotler (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396875 Fri, 08 May 2009 02:30:05 +0100 2396875 Corrigendum: Integration of an electric-metal sensory experience in the Slo1 BK channel http://www.medworm.com/index.php?rid=2396874&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0509-572b Authors: Frank T Horrigan & Toshinori Hoshi (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396874 Fri, 08 May 2009 02:30:05 +0100 2396874 Corrigendum: Telomere protection by mammalian Pot1 requires interaction with Tpp1 http://www.medworm.com/index.php?rid=2396873&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0509-572a Authors: Dirk Hockemeyer, Wilhelm Palm, Tobias Else, Jan-Peter Daniels, Kaori K Takai, Jeffrey Z-S Ye, Catherine E Keegan, Titia de Lange & Gary D Hammer (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396873 Fri, 08 May 2009 02:30:05 +0100 2396873 Nuclear transport comes full circle http://www.medworm.com/index.php?rid=2396872&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0509-457 Authors: Erik W Debler, Günter Blobel & André Hoelz Previous structural snapshots of snurportin have provided insights into its cargo recognition and nuclear import. The structure of snurportin bound to its export factor CRM1 now reveals the molecular basis of its recycling back into the cytoplasm, illuminating general principles of nuclear export sequence recognition. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396872 Fri, 08 May 2009 02:30:05 +0100 2396872 Mechanisms of APOBEC3G-catalyzed processive deamination of deoxycytidine on single-stranded DNA http://www.medworm.com/index.php?rid=2396871&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0509-454 Authors: Linda Chelico, Phuong Pham & Myron F Goodman (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396871 Fri, 08 May 2009 02:30:05 +0100 2396871 Metabolism control by the circadian clock and vice versa http://www.medworm.com/index.php?rid=2396861&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1595 Authors: Kristin Eckel-Mahan & Paolo Sassone-Corsi Circadian rhythms govern a wide variety of physiological and metabolic functions in most organisms. At the heart of these regulatory pathways in mammals is the clock machinery, a remarkably coordinated transcription-translation system that relies on dynamic changes in chromatin states. Recent findings indicate that regulation also goes the other way, as specific elements of the clock can sense changes in cellular metabolism. Understanding in full detail the intimate links between cellular metabolism and the circadian clock machinery will provide not only crucial insights into system physiology but also new avenues toward pharmacological intervention of metabolic disorders. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396861 Wed, 06 May 2009 04:00:00 +0100 2396861 Active nuclear import and cytoplasmic retention of activation-induced deaminase http://www.medworm.com/index.php?rid=2396868&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1598 Authors: Anne-Marie Patenaude, Alexandre Orthwein, Yi Hu, Vanina A Campo, Bodil Kavli, Alejandro Buschiazzo & Javier M Di Noia (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396868 Sun, 03 May 2009 04:00:00 +0100 2396868 Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis http://www.medworm.com/index.php?rid=2396870&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1593 Authors: Fang Fang Yin, Scott Bailey, C Axel Innis, Mihai Ciubotaru, Satwik Kamtekar, Thomas A Steitz & David G Schatz (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396870 Sun, 26 Apr 2009 04:00:00 +0100 2396870 A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system http://www.medworm.com/index.php?rid=2396869&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1603 Authors: Thomas Spreter, Calvin K Yip, Sarah Sanowar, Ingemar André, Tyler G Kimbrough, Marija Vuckovic, Richard A Pfuetzner, Wanyin Deng, Angel C Yu, B Brett Finlay, David Baker, Samuel I Miller & Natalie C J Strynadka (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396869 Sun, 26 Apr 2009 04:00:00 +0100 2396869 Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout http://www.medworm.com/index.php?rid=2396863&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1599 Authors: Julie L Hodgkinson, Ashley Horsley, David Stabat, Martha Simon, Steven Johnson, Paula C A da Fonseca, Edward P Morris, Joseph S Wall, Susan M Lea & Ariel J Blocker (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396863 Sun, 26 Apr 2009 04:00:00 +0100 2396863 Developmental programming of CpG island methylation profiles in the human genome http://www.medworm.com/index.php?rid=2396876&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1594 Authors: Ravid Straussman, Deborah Nejman, Douglas Roberts, Israel Steinfeld, Barak Blum, Nissim Benvenisty, Itamar Simon, Zohar Yakhini & Howard Cedar (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396876 Sun, 19 Apr 2009 04:00:00 +0100 2396876 The nucleotide binding dynamics of human MSH2–MSH3 are lesion dependent http://www.medworm.com/index.php?rid=2396867&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1596 The nucleotide binding dynamics of human MSH2–MSH3 are lesion dependent Nature Structural & Molecular Biology 16, 550 (2009). doi:10.1038/nsmb.1596 Authors: Barbara A L Owen, Walter H Lang & Cynthia T McMurray (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396867 Sun, 19 Apr 2009 04:00:00 +0100 2396867 Gemin5-snRNA interaction reveals an RNA binding function for WD repeat domains http://www.medworm.com/index.php?rid=2396866&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1584 Authors: Chi-kong Lau, Jennifer L Bachorik & Gideon Dreyfuss (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396866 Sun, 19 Apr 2009 04:00:00 +0100 2396866 miR-24–mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells http://www.medworm.com/index.php?rid=2396865&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1589 miR-24–mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells Nature Structural & Molecular Biology 16, 492 (2009). doi:10.1038/nsmb.1589 Authors: Ashish Lal, Yunfeng Pan, Francisco Navarro, Derek M Dykxhoorn, Lisa Moreau, Eti Meire, Zvi Bentwich, Judy Lieberman & Dipanjan Chowdhury (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396865 Sun, 19 Apr 2009 04:00:00 +0100 2396865 Single-molecule force spectroscopy reveals a highly compliant helical folding for the 30-nm chromatin fiber http://www.medworm.com/index.php?rid=2396864&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1590 Authors: Maarten Kruithof, Fan-Tso Chien, Andrew Routh, Colin Logie, Daniela Rhodes & John van Noort (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396864 Sun, 19 Apr 2009 04:00:00 +0100 2396864 A plant 5S ribosomal RNA mimic regulates alternative splicing of transcription factor IIIA pre-mRNAs http://www.medworm.com/index.php?rid=2396862&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb.1588 Authors: Ming C Hammond, Andreas Wachter & Ronald R Breaker (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2396862 Sun, 19 Apr 2009 04:00:00 +0100 2396862 Research highlights http://www.medworm.com/index.php?rid=2340381&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0409-352 Nature Structural & Molecular Biology 16, 352 (2009). doi:10.1038/nsmb0409-352 (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2340381 Sat, 18 Apr 2009 18:51:42 +0100 2340381 Pressing information http://www.medworm.com/index.php?rid=2340380&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0409-345 Nature Structural & Molecular Biology 16, 345 (2009). doi:10.1038/nsmb0409-345 One aim in science communication is to make the general public more aware of the breakthroughs and insights basic science research provides. Our press office gives us one route to help achieve that goal. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2340380 Sat, 18 Apr 2009 18:51:42 +0100 2340380 A tipping point for mistranslation and disease http://www.medworm.com/index.php?rid=2340379&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0409-348 Authors: Paul Schimmel & Min Guo Two papers present strong evidence that the codon-anticodon interaction is poised on a tipping point so that, given a nudge, the tRNA can insert the wrong amino acid into the growing polypeptide chain, leading to translational fidelity loss. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2340379 Sat, 18 Apr 2009 18:51:42 +0100 2340379 At the (3′) end, you'll turn to meiosis http://www.medworm.com/index.php?rid=2340378&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0409-350 At the (3′) end, you'll turn to meiosis Nature Structural & Molecular Biology 16, 350 (2009). doi:10.1038/nsmb0409-350 Authors: Alberto Moldón & José Ayté Many cellular fates are determined by different genetic programs, but the regulation of cellular differentiation is still not well understood. Besides the possible control exerted by the activity and combination of transcription factors, there are multiple RNA processing mechanisms, ensuring differential gene expression. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2340378 Sat, 18 Apr 2009 18:51:42 +0100 2340378 miR-9 and TLX: chasing tails in neural stem cells http://www.medworm.com/index.php?rid=2340377&cid=s_32093_67_f&fid=32093&url=http%3A%2F%2Fdx.doi.org%2F10.1038%2Fnsmb0409-346 Authors: Ahmet M Denli, Xinwei Cao & Fred H Gage Development and maintenance of an organism require the precise spatiotemporal orchestration of stem cell proliferation and differentiation. In neurogenesis, a microRNA and an orphan nuclear receptor comprise a negative feedback loop that regulates neural stem cell fate. (Source: Nature Structural and Molecular Biology) Nature Structural and Molecular Biology journals http://www.medworm.com/rss/comments.php?id=2340377 Sat, 18 Apr 2009 18:51:42 +0100 2340377