MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'NeLM - Anaesthesia' source. Sun, 28 Mar 2010 13:42:10 +0100 http://www.medworm.com/index.php?rid=3209498&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FEvidence%2FDisease-Focused-Reviews%2FNeuraxial-anaesthesia-for-lower-limb-revascularization%2F Source: Cochrane Library Area: Evidence > Disease Focused Reviews Background Lower-limb revascularization surgery is used to reduce pain and sometimes to improve lower-limb function. The type of anaesthesia used during lower-limb revascularization may affect the risks of both good and bad outcomes.   Objectives To determine the rates of death and major complications with spinal and epidural anaesthesia compared with other types of anaesthesia for lower-limb revascularization.   Search strategy We searched CENTRAL (The Cochrane Library 2008, Issue 2); MEDLINE (1960 to 10th June 2008); EMBASE (1982 to 10th June 2008); LILACS (1982 to 10th June 2008); CINAHL (1982 to 10th June 2008) and ISI Web of Science (1900 to 10th June 2008).   Selection criteria ... NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=3209498 Wed, 27 Jan 2010 00:00:00 +0100 3209498 http://www.medworm.com/index.php?rid=3154153&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FNews%2F2010---January%2F08%2FBOC-communication-effects-of-low-external-temperatures-on-medical-gases%2F Source: BOC Healthcare Area: News In view of the current weather conditions, BOC has issued the following reminder about the effects of low external temperatures on medical gases:   Entonox . Nitrous Oxide begins to separate out from entonox at about -6 degrees Celsius . When this occurs entonox should not be used until it has been brought back to a useable temperature as per the guidance below. . An homogenous mixture is again obtained when the temperature is raised to above 10 degrees Celsius and the cylinder is agitated    Before use and to ensure it is properly mixed:   . Cylinders should be stored horizontally for 24 hours at a temperature above 10 degrees. . If this is not practical, before use the cylinders must be mainta... NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=3154153 Fri, 08 Jan 2010 00:00:00 +0100 3154153 http://www.medworm.com/index.php?rid=3108944&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FOther-Lib-Updates%2FSPC-Changes%2FEMLA-Cream-5-Lidocaine-25-ww-Prilocaine-25-ww---Revised-SPC%2F Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC includes changes to: Section 4.8 (Undesirable Effects) -  Undesirable effects are detailed in tables in order of system organ class and frequency.  Change to frequencies in adverse events. Section 4.9 (Overdose) - Rare cases of clinically significant methaemoglobinaemia have been reported. (Source: NeLM - Anaesthesia) NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=3108944 Mon, 21 Dec 2009 00:00:00 +0100 3108944 http://www.medworm.com/index.php?rid=3102641&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FEvidence%2FDrug-Specific-Reviews%2FSugammadex-a-selective-reversal-medication-for-preventing-postoperative-residual-neuromuscular-blockade%2F Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Sugammadex is the first selective relaxant binding agent that has been studied for reversal of neuromuscular blockade induced by rocuronium and other steroidal non-depolarizing neuromuscular blocking agents (NMBAs).   Objectives To assess the efficacy and safety of sugammadex in reversing neuromuscular blockade induced by steroidal non-depolarizing NMBAs and in preventing postoperative residual neuromuscular blockade.   Search strategy We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, Issue 3), MEDLINE (1950 to August 2008), and EMBASE (1980 to August 2008). In addition, we handsearched reference lists of relevant articles and meeting abstracts. F... NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=3102641 Fri, 18 Dec 2009 00:00:00 +0100 3102641 http://www.medworm.com/index.php?rid=3013575&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FNews%2F2009---November%2F20%2FBMJ-summary-of-NPSA-safety-report-on-avoiding-midazolam-overdose%2F Source: BMJ Area: News This is the first in a series of BMJ summaries of recommendations to improve patients' safety, based on reports of safety concerns, incident analysis, and other evidence. The articles will highlight the risks of incidents that have the potential for serious harm and are not well known, and for which clear preventive actions are available. This summary is based on the safety report (rapid response report or RRR) from the NPSA in December 2008 on how to prevent overdose of midazolam. The RRR highlights evidence of harm and recommends key actions for staff. An accompanying article describes the process undertaken by the NPSA for developing rapid response reports, who to date have issued 22 RRRs. (Source: NeLM - Anaesthesia) NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=3013575 Fri, 20 Nov 2009 00:00:00 +0100 3013575 http://www.medworm.com/index.php?rid=3005173&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FOther-Lib-Updates%2FSPC-Changes%2FLidocaine-Hydrochloride-Injection-BP-1-wv-2-wv---Revised-SPC%2F Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC includes changes to: Section 4.2 (Posology and method of administration) Addition of children's age - "Single doses of Lidocaine (for anaesthesia other than spinal) should not exceed 4.5 mg/kg (or 200 mg) in adults or children 12 - 18 years of age." A further addition of: "Lidocaine by local infiltration for children under the age of 12 years should not exceed 3mg/kg, repeated not more often than every 4 hours." Section 4.3 (Contraindications) In ventricular arrhythmia: Sino-atrial disorders, all grades of atrioventricular block, severe myocardial depression, porphyria (use with caution in local anaesthesia). In local anaesthesia: complete heart block, hypovol... NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=3005173 Thu, 19 Nov 2009 00:00:00 +0100 3005173 http://www.medworm.com/index.php?rid=2836921&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FNews%2F2009---September%2F28%2FLaunch-of-new-sections-for-anaesthetics-and-critical-care-practitioners-on-MHRA-website%2F Source: MHRA Area: News The latest targeted healthcare professional group pages to be launched on the MHRA website are for anaesthetics care practitioners and for critical care practitioners. These pages aim to provide healthcare professionals with targeted information relevant to different specialities, and include guidance, safety alerts and links to educational material related to the safe use and management of medicines and medical devices. (Source: NeLM - Anaesthesia) NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=2836921 Sun, 27 Sep 2009 23:00:00 +0100 2836921 http://www.medworm.com/index.php?rid=2810547&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FOther-Lib-Updates%2FSPC-Changes%2FXylocaine-lidocaine-1-and-2-with-Adrenaline---Revised-SPC%2F Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Section 4.3 (contraindications) has been updated and now reads as follows: Hypersensitivity to local anaesthetics of the amide type, or to any of the excipients. Hypersensitivity to methyl and/or propyl parahydroxybenzoate (methyl-/propyl paraben), or to their metabolite para amino benzoic acid (PABA). Formulations of lidocaine containing parabens should be avoided in patients allergic to ester local anaesthetics or their metabolite PABA. The use of a vasoconstrictor is contra-indicated for anaesthesia of fingers, toes, tip of nose, ears and penis. Information on drugs that reduce the clearance of lidocaine has been updated in section 4.5 (interactions) and now this paragraph now reads as follo... NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=2810547 Sat, 19 Sep 2009 23:00:00 +0100 2810547 http://www.medworm.com/index.php?rid=2810546&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FOther-Lib-Updates%2FSPC-Changes%2FNeostigmine-Methylsulphate-Injection-BP-25mg-in-1ml-Hameln---Revised-SPC%2F Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Section 4.3 (contraindications) has been updated. The use of neostigmine with depolarising muscle relaxants is contraindicated.  The following statement has been added to section 4.4 (special warnings and precautions for use): Administration of anticholinesterase agents to patients with intestinal anastomoses may produce rupture of the anastomosis or leakage of intestinal contents. (Source: NeLM - Anaesthesia) NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=2810546 Sat, 19 Sep 2009 23:00:00 +0100 2810546 http://www.medworm.com/index.php?rid=2801822&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FEvidence%2FDrug-Class-Focused-Reviews%2FGreater-incidence-of-emergence-agitation-in-children-after-sevoflurane-anesthesia-as-compared-with-halothane-a-meta-analysis-of-randomized-controlled-trials%2F Source: DARE Area: Evidence > Drug Class Focused Reviews CRD Summary: This review assessed the incidence of emergence agitation in children anaesthetised with either sevoflurane or halothane. The authors concluded that sevoflurane exhibited a significantly greater incidence of emergence agitation. The authors' conclusions from this well-conducted review reflected the evidence presented and were likely to be reliable. CRD Commentary: The review addressed a clear question and consulted a wide range of sources for studies with clear inclusion criteria. The literature search was restricted to publications in English and there was no apparent search for unpublished studies, so some studies may have been missed. Both publication and language bias could have been present, as acknowledged by th... NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=2801822 Wed, 16 Sep 2009 23:00:00 +0100 2801822 http://www.medworm.com/index.php?rid=2753550&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FNews%2F2009---September%2F02%2FUpdated-national-IV-monograph-on-propofol-Propofol-Lipuro-2%2F Source: Medusa Area: News An updated IV monograph on propofol (Propofol-Lipuro 2%®) is now available from the NHS injectable medicines guide website (Medusa) at the link below (registration required for access). (Source: NeLM - Anaesthesia) NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=2753550 Tue, 01 Sep 2009 23:00:00 +0100 2753550 http://www.medworm.com/index.php?rid=2753549&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FNews%2F2009---September%2F02%2FNew-national-IV-monograph-on-propofol-Propofol-Lipuro-1%2F Source: Medusa Area: News A new IV monograph on propofol (Propofol-Lipuro 1%®) is now available from the NHS injectable medicines guide website (Medusa) at the link below (registration required for access). (Source: NeLM - Anaesthesia) NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=2753549 Tue, 01 Sep 2009 23:00:00 +0100 2753549 http://www.medworm.com/index.php?rid=2703232&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FEvidence%2FDisease-Focused-Reviews%2FLocal-versus-general-anaesthesia-for-carotid-endarterectomy%2F Source: Cochrane Library Area: Evidence > Disease Focused Reviews Background Carotid endarterectomy reduces the risk of stroke in people with recently symptomatic, severe carotid artery stenosis. However, there are significant perioperative risks which may be lessened by performing the operation under local rather than general anaesthetic. This is an update of a Cochrane Review first published in 1996, and previously updated in 2008. Objectives To assess the risks of endarterectomy under local compared with general anaesthetic. Search strategy We searched the Cochrane Stroke Group Trials Register (last searched September 2008), MEDLINE (1966 to November 2008), EMBASE (1980 to November 2008) and Index to Scientific and Technical Proceedings (ISTP) (1980 to November 2008). We also... NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=2703232 Tue, 04 Aug 2009 23:00:00 +0100 2703232 http://www.medworm.com/index.php?rid=2703233&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FOther-Lib-Updates%2FSPC-Changes%2FXylocaine-lidocaine--adrenaline-1-and-2-with-Adrenaline---Revised-SPC%2F Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes ??Section 4.3 (contraindications) now contains extra information regarding hypersensitivity to local anaesthetics of the amide type or to any of the excipients. Section 4.5 (interactions) also now includes information on drugs that reduce the clearance of lidocaine. (Source: NeLM - Anaesthesia) NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=2703233 Wed, 22 Jul 2009 23:00:00 +0100 2703233 http://www.medworm.com/index.php?rid=2703234&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FNews%2F2009---July%2F01%2FEtomidate-or-ketamine-for-emergency-intubation%2F This study intended to compare outcomes between single doses of etomidate and ketamine in critically ill patients who required sedation for intubation.   Participants ... (Source: NeLM - Anaesthesia) NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=2703234 Tue, 30 Jun 2009 23:00:00 +0100 2703234 http://www.medworm.com/index.php?rid=2703236&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FOther-Lib-Updates%2FSPC-Changes%2FHyoscine-Injection-BP-400mcgml---Revised-SPC%2F Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes ?Section 4.8 (undesirable effects) has been updated with the following side effects: dypsnoea, angiooedema, anaphalaxis and anaphalactic shock. (Source: NeLM - Anaesthesia) NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=2703236 Sat, 20 Jun 2009 23:00:00 +0100 2703236 http://www.medworm.com/index.php?rid=2703235&cid=s_38844_5_f&fid=38844&url=http%3A%2F%2Fwww.nelm.nhs.uk%2Fen%2FNeLM-Area%2FOther-Lib-Updates%2FSPC-Changes%2FKetalar-ketamine-Injection---Revised-SPC%2F Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Section 4.3 (contra-indications) has been updated and now reads: Ketalar is contra-indicated in persons in whom an elevation of blood pressure would constitute a serious hazard (see section 4.8 Undesirable effects). Ketamine hydrochloride is contraindicated in patients who have shown hypersensitivity to the drug or its components.  Ketalar should not be used in patients with eclampsia or pre-eclampsia, severe coronary or myocardial disease, cerebrovascular accident or cerebral trauma. Section 4.4 (special warnings and special precautions for use) and section 4.5 (interactions) have also been modified. (Source: NeLM - Anaesthesia) NeLM - Anaesthesia organizations http://www.medworm.com/rss/comments.php?id=2703235 Sat, 20 Jun 2009 23:00:00 +0100 2703235