MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nephron Experimental Nephrology' source. Thu, 09 Feb 2012 08:16:18 +0100 http://www.medworm.com/index.php?rid=5647921&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22286178%26dopt%3DAbstract Conclusion: Our findings suggest that Hic-5 is involved in changes in the MC phenotype to produce abnormal extracellular matrix remodeling in GN. PMID: 22286178 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5647921 Fri, 27 Jan 2012 05:00:00 +0100 5647921 http://www.medworm.com/index.php?rid=5630513&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D335780 Nephron Exp Nephrol 2012;120:e59–e68 (DOI:10.1159/000335780) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5630513 Thu, 26 Jan 2012 23:00:00 +0100 5630513 http://www.medworm.com/index.php?rid=5647924&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22286140%26dopt%3DAbstract Conclusions: BZ effectively prevents the development of nephritis in the NZB/W F1 mouse model. Specific protection of podocyte ultrastructure may critically contribute to renoprotection by BZ, which may also represent a potential new treatment option in human lupus nephritis. PMID: 22286140 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5647924 Thu, 26 Jan 2012 05:00:00 +0100 5647924 http://www.medworm.com/index.php?rid=5630514&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D334955 Nephron Exp Nephrol 2012;120:e47–e58 (DOI:10.1159/000334955) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5630514 Wed, 25 Jan 2012 23:00:00 +0100 5630514 http://www.medworm.com/index.php?rid=5593135&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22222207%26dopt%3DAbstract Authors: Laurin LP, Brissette MJ, Lepage S, Cailhier JF Abstract Experimental peritonitis is a frequently used inflammatory model to evaluate leukocyte recruitment. By the intrinsic characteristics of the peritoneal cavity, the various resident cell populations have a role to play in the initiation, the modulation and the resolution of peritoneal inflammation. Through various manipulations of these cell populations, we gained important knowledge on their respective roles in peritoneal inflammation. In this brief review, we will focus on the cellular regulation of leukocyte recruitment in experimental peritonitis. PMID: 22222207 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5593135 Thu, 05 Jan 2012 05:00:00 +0100 5593135 http://www.medworm.com/index.php?rid=5557285&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205114%26dopt%3DAbstract Conclusion: SM22α expression in podocytes and interstitial cells represented the severity of proteinuria and the deterioration of renal function. SM22α expression in renal tissues might be a hallmark of kidney diseases. PMID: 22205114 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5557285 Fri, 23 Dec 2011 05:00:00 +0100 5557285 http://www.medworm.com/index.php?rid=5557284&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205150%26dopt%3DAbstract Conclusion: The present study has shown that transplantation of metanephroi suppresses the progression of vascular calcification via a mechanism that is independent of calcium-phosphorus dynamics. PMID: 22205150 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5557284 Fri, 23 Dec 2011 05:00:00 +0100 5557284 http://www.medworm.com/index.php?rid=5526966&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D329664 Nephron Exp Nephrol 2012;120:e1–e11 (DOI:10.1159/000329664) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5526966 Thu, 22 Dec 2011 13:23:17 +0100 5526966 http://www.medworm.com/index.php?rid=5526965&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D332012 Nephron Exp Nephrol 2012;120:e32–e40 (DOI:10.1159/000332012) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5526965 Thu, 22 Dec 2011 13:23:17 +0100 5526965 http://www.medworm.com/index.php?rid=5468191&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22133868%26dopt%3DAbstract Authors: Lindenmeyer M, Noessner E, Nelson PJ, Segerer S Abstract Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses. While descriptions of cells with dendritic morphology in rodent kidneys date back to the early 1970s, a network of DCs in the mouse kidney has only recently been described. DCs acquire distinct phenotypic and functional characteristics depending on the microenvironment and the disease stages. Concomitantly, their communication with cells of the adaptive immunity might have tissue-protective or tissue-deleterious consequences. This review summarizes results from recent studies on the role of DCs in experimental renal inflammation. PMID: 22133868 [PubMed - in pro... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5468191 Sat, 03 Dec 2011 23:24:02 +0100 5468191 http://www.medworm.com/index.php?rid=5468190&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22133869%26dopt%3DAbstract Authors: Noessner E, Lindenmeyer M, Nelson PJ, Segerer S Abstract Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses. Here, we review the available information on their role in human renal inflammation. In the 1980s and early 1990s, major histocompatibility complex class II antigen- (HLA-DR) positive DCs were first described in normal human kidneys and in the interstitium of kidneys from patients with glomerulonephritis. Several DC subtypes were subsequently distinguished based on their expression of CD1c/BDCA-1, CD141/BDCA-3 and CD209/DC-SIGN (in combination with HLA-DR). These cells were almost exclusively found in the tubulointerstitium, with increased numbers seen during glome... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5468190 Sat, 03 Dec 2011 23:24:02 +0100 5468190 http://www.medworm.com/index.php?rid=5468193&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22126908%26dopt%3DAbstract Conclusions: An increase in uric acid exacerbates CsA nephropathy in the rat. Concomitant treatment with allopurinol or benzbromarone reduced the severity of renal disease. The similar protection observed with both drugs suggests that the effect is associated more with lowering uric acid levels than the antioxidant effect of allopurinol. PMID: 22126908 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5468193 Fri, 25 Nov 2011 05:00:00 +0100 5468193 http://www.medworm.com/index.php?rid=5468192&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22126970%26dopt%3DAbstract Conclusion: Our data suggest that VE-cadherin controls vascular permeability and limits fibrogenesis after UUO. PMID: 22126970 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5468192 Fri, 25 Nov 2011 05:00:00 +0100 5468192 http://www.medworm.com/index.php?rid=5365434&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D332029 Nephron Exp Nephrol 2011;119:e83–e90 (DOI:10.1159/000332029) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5365434 Thu, 03 Nov 2011 23:00:00 +0100 5365434 http://www.medworm.com/index.php?rid=5365433&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D332032 Nephron Exp Nephrol 2011;119:e91–e98 (DOI:10.1159/000332032) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5365433 Thu, 03 Nov 2011 23:00:00 +0100 5365433 http://www.medworm.com/index.php?rid=5253781&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21934330%26dopt%3DAbstract Conclusions: We conclude that Sall1-expressing cells are present in the adult mouse kidney, predominantly in the proximal tubules. Sall1-expressing cells proliferate following IRI and some of the Sall1-positive cells undergo asymmetrical cell division. Therefore, Sall1 is a promising marker for identification of stem cells present in the adult mouse kidney. PMID: 21934330 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5253781 Tue, 20 Sep 2011 04:00:00 +0100 5253781 http://www.medworm.com/index.php?rid=5239962&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D328925 Nephron Exp Nephrol 2011;119:e75–e82 (DOI:10.1159/000328925) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5239962 Mon, 19 Sep 2011 23:00:00 +0100 5239962 http://www.medworm.com/index.php?rid=5146633&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21832856%26dopt%3DAbstract Authors: Wiggins J Abstract The majority of the human population shows a decline in renal clearance with age and a loss of renal physiologic reserve. Kidneys are increasingly less able to deal with stressful challenges such as a salt or acid load. It is not clear what underlies this aging-related change and whether it is inevitable or can be modified in such a way as to preserve renal function throughout the life span. This is a very brief review of aging biology and how it might impact on renal aging. PMID: 21832856 [PubMed - in process] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5146633 Tue, 23 Aug 2011 13:56:10 +0100 5146633 http://www.medworm.com/index.php?rid=5146632&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21832857%26dopt%3DAbstract Authors: Abdelhafiz AH, Ahmed S, El Nahas M Abstract Advancing age is associated with albuminuria and vascular changes. This review will explore the putative links between the two. Vascular ageing involves endothelial dysfunction as well as increased arterial diameter, wall thickness and stiffness, ultimately leading to arterial sclerosis. This process is accelerated by a defective vascular repair process. Endothelial dysfunction is likely to be involved in the initiation and development of microalbuminuria. It is often followed by the development and progression of atherosclerosis. Initially, microalbuminuria is reversible but becomes fixed with the progression of vascular structural changes including glomerulosclerosis. The prevalence of microalbuminuria increases with age and ha... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5146632 Tue, 23 Aug 2011 13:56:10 +0100 5146632 http://www.medworm.com/index.php?rid=5146631&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21849800%26dopt%3DAbstract Conclusion: Pups exposed to losartan during lactation exhibited adverse changes in renal function and structure, and tubulointerstitial inflammation at 21 days of age that were associated with apoptosis and oxidative stress. PMID: 21849800 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5146631 Wed, 17 Aug 2011 23:00:00 +0100 5146631 http://www.medworm.com/index.php?rid=5146630&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21849801%26dopt%3DAbstract Conclusion:MPs alter endocytic functions of podocytes and induce secretion of pro-inflammatory cytokines, potentially leading to glomerular inflammation in vivo and the development of proteinuria. This study identifies a potential pathophysiological role for circulating MPs in the kidney through effects on the podocyte. PMID: 21849801 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5146630 Wed, 17 Aug 2011 23:00:00 +0100 5146630 http://www.medworm.com/index.php?rid=5146629&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21849802%26dopt%3DAbstract Conclusion: Our results reveal the differential efficacy of doxercalciferol and paricalcitol in this novel animal model incorporating both calcitriol deficiency and renal insufficiency. PMID: 21849802 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5146629 Wed, 17 Aug 2011 23:00:00 +0100 5146629 http://www.medworm.com/index.php?rid=5130167&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21832855%26dopt%3DAbstract Conclusion: Poly (I:C) induces the expression of ISG20 in mesangial cells. ISG20 may be involved in anti-viral reactions in renal mesangial cells. TLR3, IRF3 and de novo synthesized IFN-β may mediate the poly (I:C)-induced expression of ISG20, and RIG-I may mediate ISG20 expression induced by poly (I:C)/cationic lipid complex. PMID: 21832855 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5130167 Tue, 09 Aug 2011 23:00:00 +0100 5130167 http://www.medworm.com/index.php?rid=5071922&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D331227 Nephron Exp Nephrol 2011;118:I–VI (DOI:10.1159/000331227) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5071922 Wed, 27 Jul 2011 23:00:00 +0100 5071922 http://www.medworm.com/index.php?rid=5036638&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21734409%26dopt%3DAbstract Conclusions: Dietary perilla seed oil supplement could suppress the progression of IgAN. PMID: 21734409 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5036638 Wed, 06 Jul 2011 23:00:00 +0100 5036638 http://www.medworm.com/index.php?rid=5001145&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D327589 Nephron Exp Nephrol 2011;119:e33–e39 (DOI:10.1159/000327589) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=5001145 Wed, 06 Jul 2011 23:00:00 +0100 5001145 http://www.medworm.com/index.php?rid=4991557&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21659782%26dopt%3DAbstract Conclusion: Uninephrectomy greatly accelerates all features of diabetic renal damage. This procedure provides a 10-week period after surgery to examine very large changes in the pathology of DN. The model may be particularly useful for testing new therapies and for analysis of the progression of albuminuria and fibrosis in DN. PMID: 21659782 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4991557 Wed, 08 Jun 2011 23:00:00 +0100 4991557 http://www.medworm.com/index.php?rid=4905851&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D327586 Nephron Exp Nephrol 2011;119:e21–e32 (DOI:10.1159/000327586) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4905851 Wed, 08 Jun 2011 14:14:56 +0100 4905851 http://www.medworm.com/index.php?rid=4892982&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21606655%26dopt%3DAbstract Authors: Kim MJ, Frankel AH, Tam FW The application of urine proteomics is a useful approach to the study of the proteins involved in healthy and diseased kidneys and may provide a noninvasive approach to assess disease activity and to monitor clinical response in patients with renal diseases. This technique may provide an additional tool in clinical trials and for the assessment of prognosis for patients. Both soluble proteins and membrane-bound (exosomal) proteins may be studied, and multiple approaches are available. Discovery proteomics is an unbiased approach to detect novel proteins in urine samples. Mass spectrometry (MS) is often needed to identify specific protein fragments. Targeted proteomics often involves specific immunoassays or modified MS, which enables a hypothesis-bas... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4892982 Sun, 22 May 2011 23:00:00 +0100 4892982 http://www.medworm.com/index.php?rid=4892981&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21606656%26dopt%3DAbstract Conclusions: OVE26 mice induce inflammatory genes consistent with advanced renal disease, associated with severe albuminuria and to a greater extent than reported in other diabetic models. They provide an excellent model of diabetic nephropathy to assess the effect of induction of inflammatory proteins. PMID: 21606656 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4892981 Sun, 22 May 2011 23:00:00 +0100 4892981 http://www.medworm.com/index.php?rid=4672517&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D326823 Nephron Exp Nephrol 2011;117:e133 (DOI:10.1159/000326823) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4672517 Sun, 03 Apr 2011 23:00:00 +0100 4672517 http://www.medworm.com/index.php?rid=4672516&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D326824 Nephron Exp Nephrol 2011;117:e134 (DOI:10.1159/000326824) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4672516 Sun, 03 Apr 2011 23:00:00 +0100 4672516 http://www.medworm.com/index.php?rid=4672515&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D327987 Nephron Exp Nephrol 2011;117:I–VI (DOI:10.1159/000327987) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4672515 Sun, 03 Apr 2011 23:00:00 +0100 4672515 http://www.medworm.com/index.php?rid=4560753&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21372592%26dopt%3DAbstract Conclusion: Extracellular targeting of YB-1 potently induces glomerular Notch-3 receptor expression, Notch signaling and YB-1 stabilization, most likely via an autoregulatory feedback mechanism. PMID: 21372592 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4560753 Wed, 02 Mar 2011 00:00:00 +0100 4560753 http://www.medworm.com/index.php?rid=4507105&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21311199%26dopt%3DAbstract Conclusion: Our findings show that M2 macrophages can protect against islet and renal injury in streptozotocin-induced diabetes, providing a potential therapeutic strategy for diabetes and diabetic nephropathy. PMID: 21311199 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4507105 Fri, 11 Feb 2011 00:00:00 +0100 4507105 http://www.medworm.com/index.php?rid=4507106&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21311198%26dopt%3DAbstract Conclusion: Early microvascular leukocyte accumulation in the corticomedullary junction and medulla of the rat kidney after IR is ameliorated by Rho kinase inhibition. This effect is partly independent upon attenuation of decreased NO and renal blood flow. PMID: 21311198 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4507106 Thu, 10 Feb 2011 00:00:00 +0100 4507106 http://www.medworm.com/index.php?rid=4386164&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21228601%26dopt%3DAbstract Conclusion: ATRA treatment is not only an effective prophylactic strategy, but also a therapeutic strategy for the treatment of progressive renal fibrosis in diseased kidneys. PMID: 21228601 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4386164 Thu, 13 Jan 2011 00:00:00 +0100 4386164 http://www.medworm.com/index.php?rid=4386166&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21228599%26dopt%3DAbstract Conclusion: These results show for the first time that renin inhibition with ALI mitigates the profibrotic and apoptotic effects of HG in cultured podocytes. These data strengthen the therapeutic rationale for renin inhibition with ALI beyond its hemodynamic effects. PMID: 21228599 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4386166 Tue, 11 Jan 2011 00:00:00 +0100 4386166 http://www.medworm.com/index.php?rid=4386165&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21228600%26dopt%3DAbstract Conclusion: Our data showed that the blockade of PECAM-1 immediately after kidney reperfusion inhibits tubular regeneration. These observations suggest that transendothelial migration of extrarenal cells could be a precocious and pivotal step in kidney reparation, but also suggest that these extrarenal cells could be essential to the process of tubular regeneration. PMID: 21228600 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4386165 Tue, 11 Jan 2011 00:00:00 +0100 4386165 http://www.medworm.com/index.php?rid=4282883&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D320382 Nephron Exp Nephrol 2011;118:e39–e48 (DOI:10.1159/000320382) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4282883 Thu, 23 Dec 2010 18:49:51 +0100 4282883 http://www.medworm.com/index.php?rid=4279003&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D320698 Nephron Exp Nephrol 2011;118:e27–e38 (DOI:10.1159/000320698) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4279003 Wed, 22 Dec 2010 18:50:45 +0100 4279003 http://www.medworm.com/index.php?rid=4201455&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D323026 Nephron Exp Nephrol 2010;116:I–II (DOI:10.1159/000323026) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4201455 Wed, 24 Nov 2010 23:00:00 +0100 4201455 http://www.medworm.com/index.php?rid=4201454&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D323028 Nephron Exp Nephrol 2010;116:e85 (DOI:10.1159/000323028) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4201454 Wed, 24 Nov 2010 23:00:00 +0100 4201454 http://www.medworm.com/index.php?rid=4201453&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D323029 Nephron Exp Nephrol 2010;116:e86 (DOI:10.1159/000323029) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4201453 Wed, 24 Nov 2010 23:00:00 +0100 4201453 http://www.medworm.com/index.php?rid=4201452&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D323030 Nephron Exp Nephrol 2010;116:II–VI (DOI:10.1159/000323030) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4201452 Wed, 24 Nov 2010 23:00:00 +0100 4201452 http://www.medworm.com/index.php?rid=4163383&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21071976%26dopt%3DAbstract Authors: McCarthy HJ, Saleem MA Nephrotic syndrome (NS) is a disorder of the glomerular filtration barrier, a highly specialised tri-layer structure with unique functional properties. Recent advances emanating from the field of molecular genetics have revealed the podocyte as probably the central player in the control of glomerular filtration. More specifically, the cell-cell junction between adjacent podocyte foot processes, the slit diaphragm, has been revealed to be made up of a sophisticated multi-protein complex which dynamically controls foot process architecture via signalling to the actin cytoskeleton. Key genes that have been identified from the study of inherited NS include those encoding nephrin, podocin, TRPC6 and α-actinin-4, and more remain to be found. It is now possibl... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4163383 Sun, 14 Nov 2010 08:00:52 +0100 4163383 http://www.medworm.com/index.php?rid=4163382&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21071977%26dopt%3DAbstract Authors: Dixon BP, Hulbert JC, Bissler JJ Although not as common as other genetic renal diseases such as autosomal dominant polycystic kidney disease, patients with tuberous sclerosis complex frequently have significant renal involvement. Recent revelations in the cell biology of these renal disease manifestations as well as effective therapies for tuberous sclerosis complex-related renal issues have heralded hope of improved renal survival and improved quality of life for the TSC patient. This review specifically addresses some of the major renal manifestations of this disease. PMID: 21071977 [PubMed - in process] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4163382 Sun, 14 Nov 2010 08:00:27 +0100 4163382 http://www.medworm.com/index.php?rid=4163381&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21071978%26dopt%3DAbstract Authors: Maher ER Renal cell carcinoma (RCC) is a heterogeneous disorder. A variety of histopathological subtypes occur, and the molecular mechanisms associated with these subtypes can differ. Only a small fraction of all RCC is accounted for by inherited cases (e.g. von Hippel-Lindau disease, Birt-Hogg-Dubé syndrome, hereditary leiomyomatosis renal cell cancer), but such cases can pose specific clinical management issues and offer opportunities for early cancer detection and prevention. Furthermore, inherited RCC syndromes have provided important paradigms to study the molecular basis of renal tumourigenesis. The identification of molecular mechanisms of carcinogenesis in inherited RCC syndromes should lead to novel approaches to personalized therapeutics. PMID: 21071978 [PubMed ... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4163381 Sun, 14 Nov 2010 08:00:11 +0100 4163381 http://www.medworm.com/index.php?rid=4163380&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21071979%26dopt%3DAbstract Authors: Hurd TW, Hildebrandt F An emerging group of human genetic diseases termed 'ciliopathies' are caused by dysfunction of two functionally and physically associated organelles, the centrosome and cilium. These organelles are central to perception of the physical environment through detection of a diverse variety of extracellular signals such as growth factors, chemicals, light and fluid flow. Many of the described ciliopathies display multi-organ involvement, with renal and retina being the most commonly affected. Nephronophthisis is a recessive disorder of the kidney that is the leading cause of end-stage renal failure in children. Through positional cloning, many of the causative mutations have been mapped to genes involved in centrosome and cilia function. In this review, we di... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4163380 Sun, 14 Nov 2010 08:00:07 +0100 4163380 http://www.medworm.com/index.php?rid=4153337&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D321297 Nephron Exp Nephrol 2011;118:I–III (DOI:10.1159/000321297) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4153337 Tue, 09 Nov 2010 23:00:00 +0100 4153337 http://www.medworm.com/index.php?rid=4153336&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D321298 Nephron Exp Nephrol 2011;118:e27 (DOI:10.1159/000321298) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4153336 Tue, 09 Nov 2010 23:00:00 +0100 4153336 http://www.medworm.com/index.php?rid=4153335&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D321299 Nephron Exp Nephrol 2011;118:e28–e29 (DOI:10.1159/000321299) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4153335 Tue, 09 Nov 2010 23:00:00 +0100 4153335 http://www.medworm.com/index.php?rid=4074842&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20948237%26dopt%3DAbstract Conclusions: These data suggest that the addition of 1,25(OH)(2)D(3) to therapy with ARB further reduced proteinuria by suppressing the compensatory increase in renin expression in type 2 diabetic nephropathy. These effects might relate to suppression of renin, ERK1/2 and TGF-β1 expression which may or may not depend on angiotensin II. PMID: 20948237 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4074842 Tue, 12 Oct 2010 23:00:00 +0100 4074842 http://www.medworm.com/index.php?rid=4056293&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20924203%26dopt%3DAbstract Conclusion: Proliferation and the increased nuclear expression of cyclin D1 and p-Rb coincide with the early phase of cyst growth in rats and humans, suggesting that there might be a therapeutic window in which cyclin-dependent kinase inhibitors are most effective in preventing kidney enlargement in ARPKD. PMID: 20924203 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4056293 Fri, 01 Oct 2010 23:00:00 +0100 4056293 http://www.medworm.com/index.php?rid=4056292&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20924204%26dopt%3DAbstract Conclusion: SM22α was expressed in glomerular epithelial cells and interstitial cells in renal injury. SM22α is differentially upregulated in various models of renal injury and merits further study. PMID: 20924204 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4056292 Fri, 01 Oct 2010 23:00:00 +0100 4056292 http://www.medworm.com/index.php?rid=4056291&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20924205%26dopt%3DAbstract Conclusions: IL-17A directly mediates proximal tubule epithelial cell proinflammatory/profibrotic activity as demonstrated by the alteration in genes associated with extracellular matrix remodeling and cell-cell interaction, and stimulation of inflammatory mediator and immune cell chemoattractant secretion. Additionally, IL-17A may have a negative impact on barrier integrity as indicated by ZO-1 downregulation. PMID: 20924205 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4056291 Fri, 01 Oct 2010 23:00:00 +0100 4056291 http://www.medworm.com/index.php?rid=4023650&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20881432%26dopt%3DAbstract Conclusion: These results suggest that sairei-to ameliorates peritoneal fibrosis, partly through suppressing oxidative stress and macrophage infiltration. PMID: 20881432 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4023650 Fri, 24 Sep 2010 23:00:00 +0100 4023650 http://www.medworm.com/index.php?rid=4002764&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20861656%26dopt%3DAbstract Conclusion: We suggest that the renal cortex plays a significant role in clearance of injected rFVIIa and that endocytosis and degradation of rFVIIa in proximal tubule cells is mediated via binding to megalin and cubilin. PMID: 20861656 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=4002764 Tue, 21 Sep 2010 23:00:00 +0100 4002764 http://www.medworm.com/index.php?rid=3990202&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D321161 Nephron Exp Nephrol 2011;117:e82–e92 (DOI:10.1159/000321161) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3990202 Tue, 21 Sep 2010 23:00:00 +0100 3990202 http://www.medworm.com/index.php?rid=3936706&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20814218%26dopt%3DAbstract Authors: Cao Q, Zheng D, Wang YP, Harris DC Based on new understanding of the diverse biological functions of macrophages and dendritic cells (DC), the focus of studies on these cells has been expanded from their pathogenic role in renal diseases to include their potential to regulate inflammation and restore renal architecture and function. By exploiting their regulatory function, macrophages or DC have been used to treat experimental renal disease following their adoptive transfer. This review summarizes current progress in the therapeutic use of macrophages and DC in renal diseases. Key issues for ongoing research are discussed. PMID: 20814218 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3936706 Tue, 31 Aug 2010 23:00:00 +0100 3936706 http://www.medworm.com/index.php?rid=3936705&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20814219%26dopt%3DAbstract Conclusion: Par-4 gene silencing resulted in PI3K/Akt signaling-dependent inhibition of renal proximal tubular cell apoptosis following oxidative stress. PMID: 20814219 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3936705 Tue, 31 Aug 2010 23:00:00 +0100 3936705 http://www.medworm.com/index.php?rid=3936704&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20814220%26dopt%3DAbstract Conclusion: Our data established that high glucose stimulated USF2 expression in HK-2 cells, at least in part, through angiotensin II-AT1-dependent activation of CREB, which can contribute to diabetic tubulointerstitial fibrosis. PMID: 20814220 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3936704 Tue, 31 Aug 2010 23:00:00 +0100 3936704 http://www.medworm.com/index.php?rid=3896613&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20720434%26dopt%3DAbstract Conclusions: Identification of these two novel glomerulus-associated proteins opens up possibilities to investigate their role in the renal filter physiology and diseases. We speculate that sult1b1 may be involved in the sulfonylation of podocyte protein podocalyxin, whereas ankrd25 may contribute to controlling actin dynamics in podocyte foot processes. PMID: 20720434 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3896613 Tue, 17 Aug 2010 23:00:00 +0100 3896613 http://www.medworm.com/index.php?rid=3868982&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20693816%26dopt%3DAbstract Conclusion: In the Wpk rat, misexpressed proteins were identified that were also implicated in other forms of cystic disease. Numerous proteins were either over- or underexpressed in late-stage disease. Differences in protein expression may serve as biomarkers of cystic disease and its progression. PMID: 20693816 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3868982 Thu, 05 Aug 2010 23:00:00 +0100 3868982 http://www.medworm.com/index.php?rid=3832285&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20689329%26dopt%3DAbstract Conclusions: Abnormalities seen in peritoneal sclerosis can be induced in a peritoneal infusion model in rats with renal failure. However, the addition of a bioincompatible dialysis solution had no contributing role, probably because the effects were overruled by those of CGE. PMID: 20689329 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3832285 Tue, 03 Aug 2010 23:00:00 +0100 3832285 http://www.medworm.com/index.php?rid=3832284&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20689330%26dopt%3DAbstract Conclusions: Glomerulosclerosis, tubulointerstitial fibrosis, and arterial media hypertrophy lesions of hypertensive nephrosclerosis are all characterized by increased CTGF tissue expression, which is associated with a concomitant increase in CTGF in blood and urine. These findings identify CTGF as a promising biomarker for progression of hypertensive nephrosclerosis, and as a likely key factor in the pathogenesis of this disease. PMID: 20689330 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3832284 Tue, 03 Aug 2010 23:00:00 +0100 3832284 http://www.medworm.com/index.php?rid=3832283&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20689331%26dopt%3DAbstract Conclusion: Treatment with the erythropoietin receptor activators epoetin-beta or CERA protected podocytes from AGE-BSA-mediated damage via an effect on p27(Kip1) and NRP1 expression. Consequently, early treatment with erythropoietin may help to prevent diabetic nephropathy. PMID: 20689331 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3832283 Tue, 03 Aug 2010 23:00:00 +0100 3832283 http://www.medworm.com/index.php?rid=3802617&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20664297%26dopt%3DAbstract Conclusions: MCs express IL-18, which was significantly increased after LPS and AngII stimulation, but do not express appreciable levels of IL-18Ralpha. MC-derived IL-18 is unlikely to be an autocrine mediator in glomerular disease given the lack of IL-18Ralpha. PMID: 20664297 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3802617 Tue, 27 Jul 2010 23:00:00 +0100 3802617 http://www.medworm.com/index.php?rid=3802616&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20664298%26dopt%3DAbstract Conclusion: These studies demonstrate that the cytoplasmic domain of TF contributes to renal albumin retention and its renal expression protects against proteinuria in leucocyte-mediated renal inflammation. Increased glomerular production of TNFalpha in the absence of cytoplasmic domain of TF may contribute to podocyte injury resulting in albuminuria and proteinuria. PMID: 20664298 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3802616 Tue, 27 Jul 2010 23:00:00 +0100 3802616 http://www.medworm.com/index.php?rid=3796800&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D319714 Nephron Exp Nephrol 2010;115:e131 (DOI:10.1159/000319714) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3796800 Tue, 27 Jul 2010 23:00:00 +0100 3796800 http://www.medworm.com/index.php?rid=3796799&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D319715 Nephron Exp Nephrol 2010;115:e132 (DOI:10.1159/000319715) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3796799 Tue, 27 Jul 2010 23:00:00 +0100 3796799 http://www.medworm.com/index.php?rid=3796798&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D319720 Nephron Exp Nephrol 2010;115:e132 (DOI:10.1159/000319720) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3796798 Tue, 27 Jul 2010 23:00:00 +0100 3796798 http://www.medworm.com/index.php?rid=3741143&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20616569%26dopt%3DAbstract Authors: Shalamanova L, Wilkinson MC, McArdle F, Jackson MJ, Rustom R Background/Aims: Angiotensin II (AngII) is pivotal in the pathogenesis of progressive kidney disease. We have recently shown that AngII induced an increase in markers of oxidative stress, adaptive responses and upregulated stress-related gene expression in immortalised human proximal tubular (HK-2) cells. However, these observed effects of AngII were not mediated solely via AngII type 1 receptor (ATR1). Both HK-2 cells and primary human renal proximal tubular cells (RPTEC) are useful tools to investigate the renin-angiotensin system (RAS), but data on the local expression of the RAS in these cells remain limited. We therefore characterised RAS expression in RPTEC and HK-2 cells. Methods: The mRNA and protein expressi... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3741143 Wed, 07 Jul 2010 23:00:00 +0100 3741143 http://www.medworm.com/index.php?rid=3963528&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D317128 Nephron Exp Nephrol 2010;116:e23–e31 (DOI:10.1159/000317128) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3963528 Mon, 28 Jun 2010 23:00:00 +0100 3963528 http://www.medworm.com/index.php?rid=3718746&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20588061%26dopt%3DAbstract Conclusion: These data suggest that agents predicted to inhibit NF-kappaB might have opposing effects in membranous glomerulonephritis. The use of steroids to treat membranous glomerulonephritis, therefore, might produce unpredictable results, depending on whether suppression of the systemic immune response or inflammatory events within the kidney is more important in a particular patient. PMID: 20588061 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3718746 Mon, 28 Jun 2010 23:00:00 +0100 3718746 http://www.medworm.com/index.php?rid=3718745&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20588062%26dopt%3DAbstract Authors: Khan AM, Li M, Balamuthusamy S, Maderdrut JL, Simon EE, Batuman V We investigated the effects of human light chain (LC) protein-overload in mice kidney to gain further insights into the molecular mechanisms involved in the pathogenesis of myeloma kidney. Intact male C57BL/6, 10- to 12-week-old mice were given daily intraperitoneal (i.p.) injections of 1 ml of human kappa-LCs (1.5 mg/ml, low dose), or (100 mg/ml, high dose) to uninephrectomized mice for 2 weeks. Intact, sham-operated or uninephrectomized control animals were given the same volume (1 ml/day) of saline, human serum albumin (10 mg/ml) or bovine serum albumin (100 mg/ml) i.p. for 2 weeks in place of LCs. The low-dose LC-treated mice had human LCs in their urine and a significant increase in monocyte chemoattractant... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3718745 Mon, 28 Jun 2010 23:00:00 +0100 3718745 http://www.medworm.com/index.php?rid=3718744&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20588063%26dopt%3DAbstract Conclusions: PAN glomeruli already showed significant pathology by day 4, despite relatively mild proteinuria. This was preceded by altered nephrin expression, supporting its pivotal role in podocyte morphology. The novel proteins dendrin and plekhh2 were both reduced, suggesting roles in PAN, whereas alpha-actinin was unchanged. PMID: 20588063 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3718744 Mon, 28 Jun 2010 23:00:00 +0100 3718744 http://www.medworm.com/index.php?rid=3607961&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20502050%26dopt%3DAbstract Authors: Zhou YS, Turner AN PMID: 20502050 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3607961 Thu, 20 May 2010 23:00:00 +0100 3607961 http://www.medworm.com/index.php?rid=3607960&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20502051%26dopt%3DAbstract Conclusion: MZR directly prevents PAN-induced podocyte injury, possibly by affecting signaling cascades involving ILK and GSK3beta. PMID: 20502051 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3607960 Thu, 20 May 2010 23:00:00 +0100 3607960 http://www.medworm.com/index.php?rid=3607959&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20502052%26dopt%3DAbstract Conclusion: The renal protective effect of decorin in diabetic rats is at least partly due to the downregulation of the TGF-beta(1)/Smad signaling pathway. Ad-decorin shows potential as a therapeutic for human DN. PMID: 20502052 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3607959 Thu, 20 May 2010 23:00:00 +0100 3607959 http://www.medworm.com/index.php?rid=3524562&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20431304%26dopt%3DAbstract Conclusion: The downregulation of adrenomedullin during GN at the gene level can be improved by ADM application. PMID: 20431304 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3524562 Thu, 29 Apr 2010 23:00:00 +0100 3524562 http://www.medworm.com/index.php?rid=3521312&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D313833 Nephron Exp Nephrol 2010;115:e80–e88 (DOI:10.1159/000313833) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3521312 Thu, 29 Apr 2010 23:00:00 +0100 3521312 http://www.medworm.com/index.php?rid=3616339&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D313490 Nephron Exp Nephrol 2010;115:e96–e100 (DOI:10.1159/000313490) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3616339 Tue, 27 Apr 2010 23:00:00 +0100 3616339 http://www.medworm.com/index.php?rid=3616338&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D313492 Nephron Exp Nephrol 2010;115:e112–e121 (DOI:10.1159/000313492) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3616338 Tue, 27 Apr 2010 23:00:00 +0100 3616338 http://www.medworm.com/index.php?rid=3520190&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20424486%26dopt%3DAbstract Authors: Segerer S, Jedlicka J, Wüthrich RP Chemokines are structurally related proteins which form a large family of chemotactic cytokines. They provide a general communication system for cells and regulate lymphocyte migration. These proteins orchestrate the formation of microenvironments in lymphoid tissue, promote lymphoid organogenesis and help foster vascular and lymphatic angiogenesis. In addition to the classical G protein-coupled chemokine receptors, many chemokines also bind to a family of nonsignaling proteins, now called interceptors (chemokine-internalizing proteins). Here we summarize recent data on the role of interceptors in chemokine biology with a focus on renal inflammation. PMID: 20424486 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephr... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3520190 Tue, 27 Apr 2010 23:00:00 +0100 3520190 http://www.medworm.com/index.php?rid=3520189&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20424487%26dopt%3DAbstract Conclusion: Our report of DEFA1-3 expression by human omental adipocytes adds to the role of adipocytes in the primary defense against bacterial infection. This may include PD, where the presence of the catheter as a foreign body and the nonphysiological dialysis solution may require constant defense measures to prevent peritonitis, a hypothesis that will require further testing. PMID: 20424487 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3520189 Tue, 27 Apr 2010 23:00:00 +0100 3520189 http://www.medworm.com/index.php?rid=3520188&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20424488%26dopt%3DAbstract Conclusions: Improvements in the redox status and lipid peroxidation induced by AST-120 may delay the progression of CKD. PMID: 20424488 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3520188 Tue, 27 Apr 2010 23:00:00 +0100 3520188 http://www.medworm.com/index.php?rid=3520187&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20424489%26dopt%3DAbstract Conclusion: Long-term oral La overload in rats with CRF was associated with a decrease in liver (and total body) weight and mild alterations of liver function, as was Al overload, possibly as a consequence of trace element accumulation. PMID: 20424489 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3520187 Tue, 27 Apr 2010 23:00:00 +0100 3520187 http://www.medworm.com/index.php?rid=3520186&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20424490%26dopt%3DAbstract Conclusions: TLR2 and TLR4 do not play a significant role in the development of tubulointerstitial fibrosis following obstruction. PMID: 20424490 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3520186 Tue, 27 Apr 2010 23:00:00 +0100 3520186 http://www.medworm.com/index.php?rid=3513320&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D313489 Nephron Exp Nephrol 2010;115:e89–e95 (DOI:10.1159/000313489) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3513320 Tue, 27 Apr 2010 23:00:00 +0100 3513320 http://www.medworm.com/index.php?rid=3513319&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D313490 Nephron Exp Nephrol 2010;115:e96–e100 (DOI:10.1159/000313490) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3513319 Tue, 27 Apr 2010 23:00:00 +0100 3513319 http://www.medworm.com/index.php?rid=3513318&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D313491 Nephron Exp Nephrol 2010;115:e101–e111 (DOI:10.1159/000313491) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3513318 Tue, 27 Apr 2010 23:00:00 +0100 3513318 http://www.medworm.com/index.php?rid=3513317&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D313492 Nephron Exp Nephrol 2010;115:e112–e121 (DOI:10.1159/000313492) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3513317 Tue, 27 Apr 2010 23:00:00 +0100 3513317 http://www.medworm.com/index.php?rid=3513316&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D313493 Nephron Exp Nephrol 2010;115:e122–e130 (DOI:10.1159/000313493) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3513316 Tue, 27 Apr 2010 23:00:00 +0100 3513316 http://www.medworm.com/index.php?rid=3616340&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D313831 Nephron Exp Nephrol 2010;115:e60–e68 (DOI:10.1159/000313831) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3616340 Fri, 23 Apr 2010 23:00:00 +0100 3616340 http://www.medworm.com/index.php?rid=3520195&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20424481%26dopt%3DAbstract Authors: Ferenbach DA, Kluth DC, Hughes J Degradation by the inducible enzyme hemeoxygenase-1 (HO-1) is the principal route of mammalian heme metabolism. The resultant generation of free iron, carbon monoxide and biliverdin results in myriad actions including promoting cell survival, circulatory integrity and immunomodulation. This review examines the evidence from both human studies and work performed in experimental models implicating the intrinsic heme-HO-1 pathway as important in determining both the susceptibility and severity of acute kidney injury. Additional work using chemical inducers of HO-1 has demonstrated the efficacy of strategies to upregulate enzyme activity in ameliorating the severity of experimental ischaemia-reperfusion injury whilst genetic ablation of HO-1 or pha... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3520195 Fri, 23 Apr 2010 23:00:00 +0100 3520195 http://www.medworm.com/index.php?rid=3520194&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20424482%26dopt%3DAbstract In conclusion, ANGPTL3 expression is upregulated in puromycin-induced podocyte damage and is associated with the reduction of perlecan and agrin expression. PMID: 20424482 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3520194 Fri, 23 Apr 2010 23:00:00 +0100 3520194 http://www.medworm.com/index.php?rid=3520193&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20424483%26dopt%3DAbstract Conclusion: Epoetin delta treatment could delay the progression of CRF through antiapoptotic and antifibrotic mechanisms. This protective action of epoetin delta on the kidney probably is not directly related to its hematopoietic effects. PMID: 20424483 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3520193 Fri, 23 Apr 2010 23:00:00 +0100 3520193 http://www.medworm.com/index.php?rid=3520192&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20424484%26dopt%3DAbstract Conclusion: TGF-beta(1) plays a crucial role in bone matrix production but not calcium deposition in VSMCs induced by a high-phosphate environment, and the blockade of TGF-beta(1) signaling may thus be a therapeutic strategy for use with vascular disease in a high-phosphate environment. PMID: 20424484 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3520192 Fri, 23 Apr 2010 23:00:00 +0100 3520192 http://www.medworm.com/index.php?rid=3520191&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20424485%26dopt%3DAbstract Conclusion: Our findings provide a conceptual basis for the development of therapeutic strategies aiming at local inhibition of the renin-angiotensin system to prevent the progression of diabetic nephropathy. PMID: 20424485 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3520191 Fri, 23 Apr 2010 23:00:00 +0100 3520191 http://www.medworm.com/index.php?rid=3502290&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D313828 Nephron Exp Nephrol 2010;115:e33–e37 (DOI:10.1159/000313828) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3502290 Fri, 23 Apr 2010 23:00:00 +0100 3502290 http://www.medworm.com/index.php?rid=3488720&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D312882 Nephron Exp Nephrol 2010;115:e15–e21 (DOI:10.1159/000312882) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3488720 Tue, 20 Apr 2010 23:00:00 +0100 3488720 http://www.medworm.com/index.php?rid=3488719&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D312883 Nephron Exp Nephrol 2010;115:e22–e32 (DOI:10.1159/000312883) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3488719 Tue, 20 Apr 2010 23:00:00 +0100 3488719 http://www.medworm.com/index.php?rid=3478544&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D313549 Nephron Exp Nephrol 2010;114:e133 (DOI:10.1159/000313549) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3478544 Wed, 14 Apr 2010 23:00:00 +0100 3478544 http://www.medworm.com/index.php?rid=3478543&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D313550 Nephron Exp Nephrol 2010;114:e134 (DOI:10.1159/000313550) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3478543 Wed, 14 Apr 2010 23:00:00 +0100 3478543 http://www.medworm.com/index.php?rid=3478542&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D313551 Nephron Exp Nephrol 2010;114:eI–eVI (DOI:10.1159/000313551) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3478542 Wed, 14 Apr 2010 23:00:00 +0100 3478542 http://www.medworm.com/index.php?rid=3472352&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20389125%26dopt%3DAbstract Authors: Brown K, Phillips RE, Wong W The first series of kidney transplantation performed in the experimental setting over a century ago and its subsequent translation into humans has initiated a whole new facet of medical practice that has benefited a large number of patients with end-stage kidney and other organ failure. It has proven to be an indispensable tool in our quest to advance our skills and knowledge and continues to play a role in the development of better treatment protocols. Here, we discuss the advantages and drawbacks of this technique and use key examples to illustrate how it has been exploited to achieve our goals. PMID: 20389125 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3472352 Tue, 13 Apr 2010 23:00:00 +0100 3472352 http://www.medworm.com/index.php?rid=3315205&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20185935%26dopt%3DAbstract Conclusion: Using unbiased global gene expression profiling, we found that podocytes respond to PAN-induced injury by down-regulating the expression of genes involved in cell adhesion and extracellular matrix. PMID: 20185935 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3315205 Sat, 20 Feb 2010 00:00:00 +0100 3315205 http://www.medworm.com/index.php?rid=3223709&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20110732%26dopt%3DAbstract Conclusions: Alb/TGF-beta(1) transgenic mice are characterised by depletion of endogenous renal tRA. Exogenous tRA dose-dependently increases mortality and kidney fibrosis, which is associated with dose-dependent regulation of renal RALDH2 and CTGF mRNA expression. PMID: 20110732 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3223709 Thu, 21 Jan 2010 00:00:00 +0100 3223709 http://www.medworm.com/index.php?rid=3102362&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D20016221%26dopt%3DAbstract Conclusion: Cdc42 is involved in the regulation of SMA promoter activation through PAK, p38, MRTF and SRF. Cdc42 may be an important regulator of MRTF cellular localization. PMID: 20016221 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3102362 Wed, 16 Dec 2009 00:00:00 +0100 3102362 http://www.medworm.com/index.php?rid=3121512&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D265550 Nephron Exp Nephrol 2010;114:e117-e125 (DOI:10.1159/000265550) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3121512 Tue, 15 Dec 2009 23:00:00 +0100 3121512 http://www.medworm.com/index.php?rid=3091059&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D265550 Nephron Exp Nephrol 2010;114:e117-e125 (DOI:10.1159/000265550) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3091059 Tue, 15 Dec 2009 23:00:00 +0100 3091059 http://www.medworm.com/index.php?rid=3054554&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19955828%26dopt%3DAbstract Authors: Phanish MK, Winn SK, Dockrell ME Connective tissue growth factor (CTGF, CCN2) is a key mediator of tissue fibrosis. CCN2 plays an important role in the development of glomerular and tubulointerstitial fibrosis in progressive kidney diseases. In this review, we discuss the biology of CCN2 with a focus on the regulation of CCN2 gene, cellular mechanisms of profibrotic CCN2 effects and the current in vivo and in vitro evidence for the role of CCN2 in the development of renal fibrosis. We also discuss the therapeutic potential of targeting CCN2 for the treatment of renal fibrosis. PMID: 19955828 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3054554 Wed, 02 Dec 2009 00:00:00 +0100 3054554 http://www.medworm.com/index.php?rid=3054553&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19955829%26dopt%3DAbstract Conclusion: Rac1 is activated in differentiating MP and nephrin potentiates Rac1 activation. Rac1 likely contributes to lamellipodia formation in differentiating MP and may contribute to process formation in podocytes recovering from injuries. PMID: 19955829 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3054553 Wed, 02 Dec 2009 00:00:00 +0100 3054553 http://www.medworm.com/index.php?rid=3054552&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19955830%26dopt%3DAbstract Conclusion: These data suggest that mesenchymal stem cells do not significantly contribute to epithelial renewal after ischemic injury, promoting the idea that the major impact of cell-based therapy for acute kidney injury may result from paracrine or endocrine effects unrelated to stem cell transdifferentiation. PMID: 19955830 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3054552 Wed, 02 Dec 2009 00:00:00 +0100 3054552 http://www.medworm.com/index.php?rid=3121513&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D262316 Nephron Exp Nephrol 2010;114:e83-e92 (DOI:10.1159/000262316) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3121513 Tue, 01 Dec 2009 23:00:00 +0100 3121513 http://www.medworm.com/index.php?rid=3035185&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D263325 Nephron Exp Nephrol 2009;113:e113 (DOI:10.1159/000263325) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3035185 Wed, 25 Nov 2009 23:00:00 +0100 3035185 http://www.medworm.com/index.php?rid=3035184&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D263326 Nephron Exp Nephrol 2009;113:e114 (DOI:10.1159/000263326) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3035184 Wed, 25 Nov 2009 23:00:00 +0100 3035184 http://www.medworm.com/index.php?rid=3035183&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D263440 Nephron Exp Nephrol 2009;113:Indash;VI (DOI:10.1159/000263440) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3035183 Wed, 25 Nov 2009 23:00:00 +0100 3035183 http://www.medworm.com/index.php?rid=2989962&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19907192%26dopt%3DAbstract Conclusion: Low-dose DPO treatment conferred protection against acute tubular damage and attenuated interstitial fibrosis in a mouse model of AA nephropathy. Early administration of low-dose DPO may prevent the progression of acute tubular necrosis and the subsequent renal fibrosis in human AA nephropathy. PMID: 19907192 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2989962 Sat, 07 Nov 2009 00:00:00 +0100 2989962 http://www.medworm.com/index.php?rid=2967786&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19887847%26dopt%3DAbstract Authors: Liao J, Soltani Z, Ebenezer P, Isidro-Carrión AA, Zhang R, Asghar A, Aguilar E, Francis J, Hu X, Ferder L, Reisin E Metabolic syndrome increases the risk of developing diabetes as well as cardiovascular and kidney diseases. This research studied the effects of tesaglitazar, a dual-acting peroxisome proliferator-activated receptor (PPAR)alpha/gamma agonist, on metabolic abnormalities and kidney injury in obese Zucker rats (OZR). Lean Zucker rats (LZR) and OZR were used as control groups. Tesaglitazar (1 mumol/kg/day) was given for 8 weeks in the treatment group (OZR-T). Metabolic parameters, 24-hour urine albumin excretion, and tail blood pressure were measured. Glomerular filtration rate by inulin clearance, abdominal fat and renal histology were determined at the end of ... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2967786 Wed, 04 Nov 2009 00:00:00 +0100 2967786 http://www.medworm.com/index.php?rid=2967789&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19887844%26dopt%3DAbstract Authors: Anders HJ, Sayyed SA, Vielhauer V Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease. Industry has launched huge programs for the development of chemokine antagonists, and clinical trials with chemokine and chemokine receptor antagonists are ongoing. However, chemokine biology remains an area of unexpected discoveries. Here we discuss a number of questions which need to be addressed to further explore the potential of chemokine antagonism in renal inflammation: Why does renal expression of chemokines and chemokine receptors not always correlate with their functional significance? Why does chemokine antagonism only partially reduce renal leukocyte counts? Will antagonist combi... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2967789 Tue, 03 Nov 2009 00:00:00 +0100 2967789 http://www.medworm.com/index.php?rid=2967788&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19887845%26dopt%3DAbstract Conclusion: These results suggest that plasma macromolecules that appear in Bowman's space in proteinuric conditions have the capacity to induce podocyte cytokines through TLRs, and thereby accelerate podocyte injury. PMID: 19887845 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2967788 Tue, 03 Nov 2009 00:00:00 +0100 2967788 http://www.medworm.com/index.php?rid=2967787&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19887846%26dopt%3DAbstract Conclusion: VCAM-1 expression via c-Src kinase-AP-1/NF-kappaB pathways might be one of the possible mechanisms linking myoglobin to tubular injury. Losartan and simvastatin might be beneficial in attenuating myoglobin-induced tubular injury. PMID: 19887846 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2967787 Tue, 03 Nov 2009 00:00:00 +0100 2967787 http://www.medworm.com/index.php?rid=3356462&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D254390 Nephron Exp Nephrol 2010;114:e39–e47 (DOI:10.1159/000254390) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=3356462 Mon, 02 Nov 2009 23:00:00 +0100 3356462 http://www.medworm.com/index.php?rid=2956787&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D254389 Nephron Exp Nephrol 2010;114:e33-e38 (DOI:10.1159/000254389) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2956787 Mon, 02 Nov 2009 23:00:00 +0100 2956787 http://www.medworm.com/index.php?rid=2956786&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D254390 Nephron Exp Nephrol 2010;114:e39-e47 (DOI:10.1159/000254390) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2956786 Mon, 02 Nov 2009 23:00:00 +0100 2956786 http://www.medworm.com/index.php?rid=2956785&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D254391 Nephron Exp Nephrol 2010;114:e48-e60 (DOI:10.1159/000254391) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2956785 Mon, 02 Nov 2009 23:00:00 +0100 2956785 http://www.medworm.com/index.php?rid=2881377&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19816046%26dopt%3DAbstract Conclusion: Activation of rho-kinase impairs endothelium-dependent vasodilation and perfusion following renal IR, independently of COX and resultant ROS. In contrast, the vasodilatory effect of rho-kinase inhibition may be partly mediated by decreasing ROS, unrelated to COX and resultant vasoconstricting prostanoids. PMID: 19816046 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2881377 Thu, 08 Oct 2009 23:00:00 +0100 2881377 http://www.medworm.com/index.php?rid=2881376&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19816047%26dopt%3DAbstract Conclusion: GTW ameliorates prolonged glomerular lesions presumably through suppression of cytokine production (TGF-beta, IL-2, and IFN-gamma). GTW could be an effective therapeutic agent for treatment of chronic renal diseases. PMID: 19816047 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2881376 Thu, 08 Oct 2009 23:00:00 +0100 2881376 http://www.medworm.com/index.php?rid=2881375&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19816048%26dopt%3DAbstract Authors: Beltcheva O, Hjorleifsdottir EE, Kontusaari S, Tryggvason K We have analyzed a conserved 237-bp segment located in a 1.9-kb upstream region of the nephrin gene, previously shown to contain kidney specific enhancer element(s). Electromobility shift assay was used to identify a 20-nucleotide region specifically recognized and bound by protein factors in nuclear extracts from immortalized podocyte and human embryonic kidney cell lines. The region was further narrowed down by competition assays to a stretch of 6 consecutive guanines, which are conserved at this location in multiple species. Introduction of mutations in this sequence abolished all protein binding activity whereas mutations in the flanking nucleotides did not. By means of gel supershift and chromatin immunoprecipita... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2881375 Thu, 08 Oct 2009 23:00:00 +0100 2881375 http://www.medworm.com/index.php?rid=2881374&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19816049%26dopt%3DAbstract Conclusion: These data suggest that BMP-7 can block CsA-induced EMT by downregulating the expression of CTGF, a downstream mediator of EMT. PMID: 19816049 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2881374 Thu, 08 Oct 2009 23:00:00 +0100 2881374 http://www.medworm.com/index.php?rid=2877921&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D245060 Nephron Exp Nephrol 2010;114:e1-e6 (DOI:10.1159/000245060) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2877921 Thu, 08 Oct 2009 23:00:00 +0100 2877921 http://www.medworm.com/index.php?rid=2877920&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D245061 Nephron Exp Nephrol 2010;114:e7-e14 (DOI:10.1159/000245061) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2877920 Thu, 08 Oct 2009 23:00:00 +0100 2877920 http://www.medworm.com/index.php?rid=2877919&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D245062 Nephron Exp Nephrol 2010;114:e15-e22 (DOI:10.1159/000245062) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2877919 Thu, 08 Oct 2009 23:00:00 +0100 2877919 http://www.medworm.com/index.php?rid=2877918&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D245063 Nephron Exp Nephrol 2010;114:e23-e31 (DOI:10.1159/000245063) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2877918 Thu, 08 Oct 2009 23:00:00 +0100 2877918 http://www.medworm.com/index.php?rid=2744901&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19713707%26dopt%3DAbstract Conclusion: We demonstrated that LA attenuates cisplatin-induced renal tubular damages by inhibition of mitochondrial bax translocation in vivo. PMID: 19713707 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2744901 Wed, 26 Aug 2009 23:00:00 +0100 2744901 http://www.medworm.com/index.php?rid=2711010&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19684413%26dopt%3DAbstract Conclusions: These results indicate that cortactin mediates interaction between podocalyxin and actin filaments in podocytes and that alteration of this interaction may play a role in the process of morphological change of podocytes. PMID: 19684413 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2711010 Thu, 13 Aug 2009 23:00:00 +0100 2711010 http://www.medworm.com/index.php?rid=2711009&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19684414%26dopt%3DAbstract Authors: Richards A, Kavanagh D Animal models are important experimental tools for investigating the molecular mechanisms, environmental and genetic susceptibilities underlying the development of thrombotic microangiopathies. Large mammal, small animal models, knockout, transgenic and conditional knockout mouse models are available to investigate haemolytic uraemic syndrome, thrombotic thrombocytopenic purpura and vascular endothelial growth factor-associated thrombotic microangiopathy. These models have shown that it is possible to model the human conditions. However, differences in human and rodent physiology mean that caution is required when interpreting the findings. These models offer realistic prospects for identifying and testing novel therapeutic strategies in a range of throm... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2711009 Wed, 12 Aug 2009 23:00:00 +0100 2711009 http://www.medworm.com/index.php?rid=2696208&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19672121%26dopt%3DAbstract Conclusions: These results demonstrate for the first time an important role for T-CaCN in human MC proliferation. This could potentially lead to a novel therapy in the treatment of proliferative renal diseases. PMID: 19672121 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2696208 Mon, 10 Aug 2009 23:00:00 +0100 2696208 http://www.medworm.com/index.php?rid=2614463&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19609084%26dopt%3DAbstract Conclusions: It appears that enalapril and/or losartan, especially in combination, inhibited accumulation of CML/MDA/4-HNE in diabetic renal tissues. These effects might be related to lipid peroxidation via tissue-specific activation of adiponectin and AMPK. PMID: 19609084 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2614463 Wed, 15 Jul 2009 23:00:00 +0100 2614463 http://www.medworm.com/index.php?rid=2591897&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19590241%26dopt%3DAbstract Conclusion: The expression of FKN/CX3CL1 in normal podocytes and the increased expression of the membrane-anchored form in nephrotic glomeruli strongly suggest that FKN/CX3CL1 may play roles in glomerular physiology such as maintaining glomerular filtration barrier. PMID: 19590241 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2591897 Thu, 09 Jul 2009 23:00:00 +0100 2591897 http://www.medworm.com/index.php?rid=2591896&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19590242%26dopt%3DAbstract Conclusion: For the first time a link between the activation of viral receptors on MC and potentially causative agents in the development of glomerulosclerosis and tubulointerstitial fibrosis is shown. The progression of inflammatory processes to glomerulosclerosis can be postulated to be directly enhanced by viral infection. PMID: 19590242 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2591896 Thu, 09 Jul 2009 23:00:00 +0100 2591896 http://www.medworm.com/index.php?rid=2669346&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D233954 Nephron Exp Nephrol 2009;112:e99 (DOI:10.1159/000233954) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2669346 Thu, 09 Jul 2009 13:46:46 +0100 2669346 http://www.medworm.com/index.php?rid=2669345&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D233955 Nephron Exp Nephrol 2009;112:e100 (DOI:10.1159/000233955) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2669345 Thu, 09 Jul 2009 13:46:46 +0100 2669345 http://www.medworm.com/index.php?rid=2669344&cid=s_36079_25_f&fid=33545&url=http%3A%2F%2Fcontent.karger.com%2Fproduktedb%2Fprodukte.asp%3Fdoi%3D233958 Nephron Exp Nephrol 2009;112:I-IV (DOI:10.1159/000233958) (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2669344 Thu, 09 Jul 2009 13:46:46 +0100 2669344 http://www.medworm.com/index.php?rid=2591902&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19590236%26dopt%3DAbstract Authors: Robson MG Toll-like receptors (TLRs) play a central role in the response of both the innate and the adaptive immune system to microbial ligands. There is also evidence that they are stimulated by endogenous ligands. In this review, I discuss evidence that they are important in renal disease. This discussion considers the role of both endogenous and microbial ligands, and also the contribution of TLRs present on leucocytes and on intrinsic renal cells. There is strong evidence of a role for TLR2 and TLR4 in renal ischaemia-reperfusion injury, with the effects probably mediated by endogenous ligands. In systemic lupus erythematosus, stimulation of TLR7 and TLR9 by host-derived nucleic acids is important. TLR7 stimulation exacerbates disease, but the role of TLR9 is complex. I al... Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2591902 Wed, 08 Jul 2009 23:00:00 +0100 2591902 http://www.medworm.com/index.php?rid=2591901&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19590237%26dopt%3DAbstract In conclusion, the bioactivity of glomerular VEGF is regulated by many factors that are themselves moderated by changes in the local glomerular environment, such as mechanical strain and hyperglycaemia. Thus, to understand VEGF signalling in glomerular disease progression, we must examine it in the context of other appropriate cellular factors. PMID: 19590237 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2591901 Wed, 08 Jul 2009 23:00:00 +0100 2591901 http://www.medworm.com/index.php?rid=2591900&cid=s_36079_47_f&fid=36079&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D19590238%26dopt%3DAbstract Conclusions: YB-1 has an apparent stimulatory effect on c-Raf, MEK1/2, ERK1/2 and cell-cycle progression in MCs, after which activated ERK1/2 goes on to upregulate YB-1 expression and augment the proliferative effect of YB-1. PMID: 19590238 [PubMed - as supplied by publisher] (Source: Nephron Experimental Nephrology) Nephron Experimental Nephrology journals http://www.medworm.com/rss/comments.php?id=2591900 Wed, 08 Jul 2009 23:00:00 +0100 2591900