MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Neurogastroenterology and Motility' source. Wed, 08 Feb 2012 16:28:28 +0100 http://www.medworm.com/index.php?rid=5667835&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01844.x Conclusions & Inferences  Disruption of the normal inhibitory function of h‐CaD enhances intestinal peristalsis in both wild‐type zebrafish larvae and mutant larvae that lack enteric nerves, thus confirming a physiologic role for regulation of smooth muscle contraction at the actin filament. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5667835 Wed, 08 Feb 2012 20:46:44 +0100 5667835 http://www.medworm.com/index.php?rid=5667834&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01864.x Conclusions & Inferences  With improved manometric instrumentation, larger participant numbers, and methodology that controlled for potential confounding factors, this study confirms and advances the results of the previous pilot study: Volitional manipulation of the oropharyngeal phase of swallowing using the effortful swallow indeed affects esophageal physiology. Thus, the effortful swallow offers a behavioral manipulation of the esophageal phase of swallowing, and future studies will determine its clinical potential for treating esophageal dysmotility in patient populations. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5667834 Wed, 08 Feb 2012 20:46:36 +0100 5667834 http://www.medworm.com/index.php?rid=5667833&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01867.x AbstractVisceral hypersensitivity is one of the hallmarks in irritable bowel syndrome (IBS) pathophysiology. Stress is well known to affect visceral sensitivity in humans and rodents, an effect which is associated in part with alterations of intestinal epithelial permeability in rodents. Although the pathophysiology of visceral hypersensitivity is still unclear, two key factors have been identified as playing a major role in its modulation, namely peripheral corticotropin‐releasing factor (CRF) and mast cells. In a recent study in Neurogastroenterology and Motility, van den Wijngaard et al. demonstrate that the mast‐cell dependent visceral hypersensitivity observed in maternally separated rats after an acute exposure to a psychological stress can be prevented but not reversed by the p... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5667833 Wed, 08 Feb 2012 20:46:24 +0100 5667833 http://www.medworm.com/index.php?rid=5667828&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2012.01886.x Conclusions & Inferences  This simple, but unexplored imaging technique can provide a means to monitor intestinal motility disorders and response to therapeutic agents. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5667828 Wed, 08 Feb 2012 20:45:37 +0100 5667828 http://www.medworm.com/index.php?rid=5667832&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2012.01888.x Conclusions & Inferences  In well‐defined NERD patients, the estimated complete symptom response rate after PPI therapy is comparable to the response rate in patients with ERD. The previously reported low response rate in studies with patients classified as NERD is likely the result of inclusion of patients with upper gastrointestinal symptoms that do not have reflux disease. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5667832 Mon, 06 Feb 2012 05:00:00 +0100 5667832 http://www.medworm.com/index.php?rid=5667831&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01869.x Conclusions & Inferences  Only half the patients with acquired brain injury avoided aspiration during cervical flexion; 48% of silent aspirators continued to aspire during the maneuver. Several videofluoroscopic parameters were related to inefficiency of the maneuver. Therefore, the indication for chin‐down posture should be evaluated by videofluoroscopic examination. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5667831 Mon, 06 Feb 2012 05:00:00 +0100 5667831 http://www.medworm.com/index.php?rid=5667830&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2012.01877.x Conclusions & Inferences  Our study suggests that manual stimulation of acupuncture needles at ST36 and PC6 affects gastric myoelectrical as well as cardiac activities in healthy volunteers. The effect of stimulation in acupuncture deserves further investigation. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5667830 Mon, 06 Feb 2012 05:00:00 +0100 5667830 http://www.medworm.com/index.php?rid=5667829&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2012.01883.x Conclusions & Inferences  Our results suggest that distension is an important stimulus for intestinal contractility and nervous regulation is implicated in the intestinal contractility response to mechanical stimulus. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5667829 Mon, 06 Feb 2012 05:00:00 +0100 5667829 http://www.medworm.com/index.php?rid=5660507&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2012.01890.x Conclusions & Inferences  Colonic motility was restored to approximately 70% normal over 1 week without further improvement at 2 weeks. Enteric nervous system compensated by upregulating mucosal 5‐HT3, but not 5‐HT4, receptors. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5660507 Sun, 05 Feb 2012 20:39:57 +0100 5660507 http://www.medworm.com/index.php?rid=5648982&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01861.x Conclusions & Inferences  The findings suggest a valuable therapeutic role of LAB especially when incorporated into alginate beads for the treatment of CFS. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5648982 Thu, 02 Feb 2012 20:48:30 +0100 5648982 http://www.medworm.com/index.php?rid=5660508&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2012.01880.x Conclusions & Inferences  Our results suggest excessive duodenal lipid‐induced release of apoA‐IV and CCK in GERD. We postulate that the resulting heightened activation of duodenal vagal afferents may underlie central sensitization, thereby increasing the perception of reflux events. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5660508 Thu, 02 Feb 2012 05:00:00 +0100 5660508 http://www.medworm.com/index.php?rid=5648983&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2012.01881.x Conclusions & Inferences  Increase in intracellular Ca2+ will activate the maxi chloride channels. Maxi chloride currents are inwardly rectifying in the cell‐attached patch clamp configuration under physiological conditions and are outwardly rectifying in the inside‐out configuration. The same channel is responsible for both currents. Ca2+ does not appear to regulate the rectification. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5648983 Wed, 01 Feb 2012 05:00:00 +0100 5648983 http://www.medworm.com/index.php?rid=5648987&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01862.x Conclusions & Inferences  Wireless motility capsule was able to detect the phase III MMCs as the high amplitude contractions with good fidelity. WMC does not detect the propagation of MMC. Using the pressure thresholds, WMC can detect high amplitude contraction representing phase III MMC with favorable sensitivity/specificity profile and 99.9% negative predictive value. This observation may have clinical significance, as the absence of high amplitude contractions recorded by WMC during fasting state suggests absence of MMCs. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5648987 Tue, 31 Jan 2012 05:00:00 +0100 5648987 http://www.medworm.com/index.php?rid=5648986&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01872.x Conclusions & Inferences  Persons with FGIDs are affected by impairment of sleep, eating habits, diet, exercise and other lifestyle factors, and feel excessive stress. This suggests that offering lifestyle guidance to FGID patients may be useful. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5648986 Tue, 31 Jan 2012 05:00:00 +0100 5648986 http://www.medworm.com/index.php?rid=5648985&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2012.01878.x Conclusions & Inferences  Short‐term stimulation of the LES in patients with GERD significantly increases resting LESP without affecting esophageal peristalsis or LES relaxation. Electrical stimulation of the LES may offer a novel therapy for patients with GERD. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5648985 Tue, 31 Jan 2012 05:00:00 +0100 5648985 http://www.medworm.com/index.php?rid=5648984&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2012.01887.x Conclusions & Inferences  The parallel analysis of colonic mucosa, along with the SMP, can help detect Lewy pathology in PD. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5648984 Tue, 31 Jan 2012 05:00:00 +0100 5648984 http://www.medworm.com/index.php?rid=5648989&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01874.x Conclusions & Inferences  Overall, DRO 2.5 or 5 mg twice per day for 2 days had no effect on gut transit in IBS‐D. There appears to be a treatment‐by‐genotype effect, whereby DRO preferentially delays colonic transit in those with the CNR1 rs806378 CT/TT genotypes. Further study of CB pharmacogenetics may help identify a subset of IBS‐D patients most likely to benefit from CB agonist therapy. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5648989 Mon, 30 Jan 2012 05:00:00 +0100 5648989 http://www.medworm.com/index.php?rid=5648988&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2012.01876.x Conclusions & Inferences  Gastric morphology is related to upper GI symptoms in both men and women. Cascade stomach should be reconsidered as a pathophysiological factor associated with upper GI symptoms. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5648988 Mon, 30 Jan 2012 05:00:00 +0100 5648988 http://www.medworm.com/index.php?rid=5639007&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2012.01879.x Conclusions & Inferences   Symptoms of early satiety, nausea, postprandial fullness, and bloating were responsive to treatment for gastroparesis. A composite of these symptoms also demonstrates validity and responsiveness to treatment for gastroparesis, and may represent an acceptable endpoint for evaluating the effectiveness of medical treatments in clinical trials for gastroparesis. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5639007 Sun, 29 Jan 2012 20:48:39 +0100 5639007 http://www.medworm.com/index.php?rid=5639008&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01875.x Conclusions & Inferences  Progesterone decreased the contractility of circular muscle strips, and reduced the fecal output in two diarrheal models, the SERT‐KO and fluoxetine‐treated mice. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5639008 Fri, 27 Jan 2012 05:00:00 +0100 5639008 http://www.medworm.com/index.php?rid=5629591&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01873.x Conclusions & Inferences  The success of acid suppression on chronic laryngitis could be predicted using reflux parameters detected by MII‐pH, among which increased laryngopharyngeal BET is the best. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5629591 Thu, 26 Jan 2012 21:07:07 +0100 5629591 http://www.medworm.com/index.php?rid=5629595&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01865.x Conclusions & Inferences  This study illustrates that a probiotic food containing B. lactis CNCM I‐2494 strain reduces visceral hypersensitivity associated with acute stress by normalizing intestinal epithelial barrier via a synergistic interplay with the different probiotic strains and/or metabolites contained in this product. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5629595 Wed, 25 Jan 2012 05:00:00 +0100 5629595 http://www.medworm.com/index.php?rid=5629594&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01871.x Conclusions & Inferences  Gastric emptying rate and antral motility parameters were significantly impaired in patients with FAP and GER negatively correlated with symptom severity. These findings highlight the possible role of gastrointestinal motility abnormalities in the pathophysiology of childhood FAP. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5629594 Wed, 25 Jan 2012 05:00:00 +0100 5629594 http://www.medworm.com/index.php?rid=5629593&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01863.x Conclusions & Inferences  Patients with symptomatic diverticular disease exhibit visceral hypersensitivity, and this may be mediated by ongoing low grade inflammation and upregulation of tachykinins. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5629593 Wed, 25 Jan 2012 05:00:00 +0100 5629593 http://www.medworm.com/index.php?rid=5629592&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01870.x Conclusions & Inferences  SS catheters are more sensitive in recording HAPCs in children with defecation disorders compared with the more traditional WP assembly. There is a difference in measurements of amplitude between the two systems. Solid‐state catheters offer potential advantages over WP catheters in children, being portable, safer to use, and may provide data over a more prolonged period. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5629592 Wed, 25 Jan 2012 05:00:00 +0100 5629592 http://www.medworm.com/index.php?rid=5609828&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01868.x Conclusions & Inferences  Human mGluR5, GABAA,B, and CB1,2 receptors are abundantly expressed along the vago‐vagal neural pathway and involved in the triggering of TLESRs. These findings are not only in line with the central side effects observed during treatment with reflux inhibitors such as GABAB receptor agonists and mGluR5 antagonists, but also suggest that peripherally acting compounds may be effective. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5609828 Fri, 20 Jan 2012 20:42:28 +0100 5609828 http://www.medworm.com/index.php?rid=5609829&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01866.x Conclusions & Inferences  Patients with IBS appear to experience symptoms that may be the result of changes in ANS functioning. HRV measures in clinical routine may allow assessing these changes, but further studies performed in a standardized fashion should improve the validity of HRV measures for clinical research first. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5609829 Thu, 19 Jan 2012 05:00:00 +0100 5609829 http://www.medworm.com/index.php?rid=5598611&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01834.x AbstractBackground  The Chicago Classification of esophageal motility was developed to facilitate the interpretation of clinical high resolution esophageal pressure topography (EPT) studies, concurrent with the widespread adoption of this technology into clinical practice. The Chicago Classification has been an evolutionary process, molded first by published evidence pertinent to the clinical interpretation of high resolution manometry (HRM) studies and secondarily by group experience when suitable evidence is lacking.Purpose  This publication summarizes the state of our knowledge as of the most recent meeting of the International High Resolution Manometry Working Group in Ascona, Switzerland in April 2011. The prior iteration of the Chicago Classification was updated through a process... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5598611 Tue, 17 Jan 2012 21:40:01 +0100 5598611 http://www.medworm.com/index.php?rid=5598610&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01835.x AbstractBackground  Symptom based diagnosis is not reliable in patients with swallowing problems, heartburn, and other dyspeptic complaints. The aim of investigation is to provide clinically relevant measurements of gastrointestinal structure and function that explain the cause of symptoms, identify pathology, and guide effective management. Current practice rarely meets these ideals.Purpose  This review considers recent advances in technology such as high‐resolution manometry (HRM) with esophageal pressure topography (EPT), HRM with impedance, high frequency ultrasound, and endoscopic functional luminal impedance planimetry (Endo‐FLIP) that provide new opportunities to identify the pathophysiologic basis of esophageal symptoms and disease. As experience with these new devices incr... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5598610 Tue, 17 Jan 2012 21:39:59 +0100 5598610 http://www.medworm.com/index.php?rid=5598609&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01831.x This article aims to review the current insights in the terminology, pathology, pathophysiology, clinical manifestations, diagnostic work‐up,and management of weak and absent peristalsis. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5598609 Tue, 17 Jan 2012 21:39:57 +0100 5598609 http://www.medworm.com/index.php?rid=5598608&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01837.x Conclusions & Inferences  Hypertensive motility disorders represent a heterogeneous condition subdivided into hypercontractile esophagus and hypertensive peristalsis. Further studies are required to determine the clinical relevance of this new classification. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5598608 Tue, 17 Jan 2012 21:39:56 +0100 5598608 http://www.medworm.com/index.php?rid=5598607&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01833.x AbstractBackground  The choice between pneumatic dilation and surgical myotomy is mainly determined by the preference and expertise of the treating physician. Ideally, however, treatment should be personalized to provide the optimal clinical outcome. The introduction of high resolution manometry has not only improved the specificity to diagnose achalasia, but also identified three different manometric subclasses.Purpose  To review, the data suggesting differences in clinical response to treatment depending on the manometric profile. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5598607 Tue, 17 Jan 2012 21:39:54 +0100 5598607 http://www.medworm.com/index.php?rid=5598606&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01832.x AbstractBackground  High‐resolution manometry and esophageal pressure topography have enhanced our ability to analyze esophageal motor disturbances by improving the detail and accuracy of measurements of peristaltic activity.This has been extremely helpful in the evaluation of disorders of rapid propagation as the technique is able to define important time points and physiologic landmarks that are crucial in defining peristaltic velocity and latency intervals.Purpose  The goal of the current review will be to assess how esophageal pressure topography has impacted our ability to define important phenotypes of rapid propagation. Additionally, this review will also be utilized to complement the description of the Chicago Classification of Esophageal Motor Disorders, which is presented i... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5598606 Tue, 17 Jan 2012 21:39:52 +0100 5598606 http://www.medworm.com/index.php?rid=5598605&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01829.x AbstractBackground  The assessment of the esophagogastric junction (EGJ) is the most challenging aspect of clinical esophageal manometry. Although conventional manometric systems can be optimized toward interrogating specific aspects of the EGJ, they are too limited in recording channels and/or fidelity for a comprehensive assessment. The technological advantages inherent in high resolution manometry (HRM) with esophageal pressure topography (EPT) analysis substantially change this equation providing a technology sufficiently robust to dynamically record the contractile activity within the EGJ with both good fidelity and good spatial resolution.Purpose  This review is an update on our understanding of the application of HRM and EPT to the analysis of EGJ function. With respect to sphin... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5598605 Tue, 17 Jan 2012 21:39:50 +0100 5598605 http://www.medworm.com/index.php?rid=5598604&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01830.x AbstractBackground  A number of commercial and research systems are available for making high‐resolution manometry recordings.Purpose  In this document, we review the standard equipment, patient preparation and routine protocol for high‐resolution manometry. The major differences between HRM systems lie in the method of signal transduction, with solid‐state catheter systems recording form intraluminal transducers and water perfusion systems recording pressures from external transducers via a perfused silicone catheter. The variations in recording systems result in different mechanical and electrical characteristics which dictate different techniques for setting up and using equipment. These issues are relevant in terms of costs and day to day management, but have little clinical s... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5598604 Tue, 17 Jan 2012 21:39:49 +0100 5598604 http://www.medworm.com/index.php?rid=5598603&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01836.x (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5598603 Tue, 17 Jan 2012 21:39:47 +0100 5598603 http://www.medworm.com/index.php?rid=5598602&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01838.x (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5598602 Tue, 17 Jan 2012 21:39:45 +0100 5598602 http://www.medworm.com/index.php?rid=5583120&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01855.x Conclusions & Inferences  We conclude from these data that interstitial intestinal edema inhibits MLC phosphorylation predominantly by decreasing inhibitory phosphorylation of the MLC targeting subunit (MYPT1) of MLC phosphatase via decreased ROCK and ZIPK activities, resulting in more MLC phosphatase activity. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5583120 Wed, 11 Jan 2012 05:00:00 +0100 5583120 http://www.medworm.com/index.php?rid=5583119&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01856.x Conclusions & Inferences  The oscillator(s) driving the EUS operate(s) at a frequency twice that of the EAS. This may explain the presence of type 2B fibers in the EUS. In the inter‐micturition periods no cross correlation was found in motor discharge to the sphincters suggesting that the two muscles do not share a common central drive to sustain the continent tonus of the two outlet tracts. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5583119 Wed, 11 Jan 2012 05:00:00 +0100 5583119 http://www.medworm.com/index.php?rid=5583118&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01857.x Conclusions & Inferences  Recto‐anal inhibitory reflex is characterized by differential anal relaxation along anterior–posterior axis, longitudinally along the length of anal canal, and it depends on the rectal distention volume. It is maximally seen at internal anal sphincter pressure zone. Multidimensional analyses indicate that external anal sphincter provides bulk of anal residual pressure. Our findings emphasize importance of sensor location and orientation; as anterior and more distal location may miss RAIR. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5583118 Wed, 11 Jan 2012 05:00:00 +0100 5583118 http://www.medworm.com/index.php?rid=5583117&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01858.x Conclusions & Inferences  Irradiation for prostate cancer leads to reduced rectal distensibility. In patients with urgency symptoms, anal sphincter function was also impaired. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5583117 Wed, 11 Jan 2012 05:00:00 +0100 5583117 http://www.medworm.com/index.php?rid=5583116&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01859.x Conclusions & Inferences  The severity of dyspepsia symptoms is associated with the presence of bowel symptoms especially in PDS. This novel categorization of FD based on concomitant constipation or diarrhea may improve classification of patients. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5583116 Wed, 11 Jan 2012 05:00:00 +0100 5583116 http://www.medworm.com/index.php?rid=5583115&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01860.x Conclusions & Inferences  Cannabinoid receptors inhibit transmitter release at enteric synapses and depress synaptic strength basally and in an activity‐dependent manner. These actions help explain accelerated intestinal transit observed in the absence of CB1 receptors. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5583115 Sun, 01 Jan 2012 05:00:00 +0100 5583115 http://www.medworm.com/index.php?rid=5560953&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01839.x Conclusions & Inferences  The development of a porcine model of percutaneous SNS revealed the ability of neuromodulation to reinforce rectal epithelial barrier. Furthermore, our results suggest that SNS could be used for treatment of gastrointestinal pathologies with reduced rectal mucosal barrier functions (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5560953 Sun, 01 Jan 2012 05:00:00 +0100 5560953 http://www.medworm.com/index.php?rid=5525778&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01814.x (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5525778 Thu, 22 Dec 2011 09:11:29 +0100 5525778 http://www.medworm.com/index.php?rid=5525777&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01817.x Conclusions & Inferences  Thermal effect is well compensated in the current operation of the system but baseline drift is not well recognized or addressed. Incorporation of a linear correction into current software would improve accuracy without impact on ease of use. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5525777 Thu, 22 Dec 2011 09:11:15 +0100 5525777 http://www.medworm.com/index.php?rid=5525776&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01843.x AbstractBackground and Purpose  Functional tissue engineering of the gastrointestinal (GI) tract is a complex process aiming to aid the regeneration of structural layers of smooth muscle, intrinsic enteric neuronal plexuses, specialized mucosa, and epithelial cells as well as interstitial cells. The final tissue‐engineered construct is intended to mimic the native GI tract anatomically and physiologically. Physiological functionality of tissue‐engineered constructs is of utmost importance while considering clinical translation. The construct comprises of cellular components as well as biomaterial scaffolding components. Together, these determine the immune response a tissue‐engineered construct would elicit from a host upon implantation. Over the last decade, significant advances h... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5525776 Thu, 22 Dec 2011 09:11:03 +0100 5525776 http://www.medworm.com/index.php?rid=5525775&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01815.x AbstractExtracellular electrical recordings underpin an important literature of basic and clinical motility science. In the November 2011 edition of Neurogastroenterology and Motility, Sanders and colleagues reported that contraction artifacts could be recorded from in vitro murine gastric tissues using extracellular electrodes, and that true extracellular bioelectrical activity could not be detected when the contractions were suppressed. The authors interpret their findings to mean that previous extracellular studies have generally assayed contraction artifacts, rather than bioelectrical activity, and suggest that movement suppression is an obligatory control for extracellular experiments. If their interpretation is correct, these claims would be significant, requiring a reinterpretation ... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5525775 Thu, 22 Dec 2011 09:11:02 +0100 5525775 http://www.medworm.com/index.php?rid=5525770&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01850.x Conclusions & Inferences  Patients with OD associated to rectal intussusception display abnormalities of the ENS and of estrogen receptors β. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5525770 Thu, 22 Dec 2011 09:10:22 +0100 5525770 http://www.medworm.com/index.php?rid=5525774&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01847.x Conclusions & Inferences  There is a need for additional reporting of such cases and further research. Our experience would suggest that a delay in the involvement of a specialist liaison psychiatrist has the potential to be life threatening in such cases. This may be more likely with greater severity, where the apparent predominance of ‘physical’ symptoms generates reluctance in both patient and physician to consider a psychiatric etiology and also appears to occur due to a lengthier investigative process than existed previously. We therefore propose that the provision of a specialist psychiatric assessment for all patients presenting with IF is indicated at the point of initial clinical contact, based upon the substantial clinical benefit it has the potential to confer upon a s... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5525774 Wed, 21 Dec 2011 05:00:00 +0100 5525774 http://www.medworm.com/index.php?rid=5525773&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01849.x Conclusions & Inferences  Dietary copper deficiency produces significant changes in the neural regulation of colonic smooth muscle contractility in a rodent model. Thus, along with CNS and PNS effects in humans, copper deficiency results in abnormal ENS regulation of intestinal function in rats. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5525773 Wed, 21 Dec 2011 05:00:00 +0100 5525773 http://www.medworm.com/index.php?rid=5525772&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01851.x Conclusions & Inferences  Our results provide the first anatomical evidence for direct OXT‐immunoreactive innervation of GI‐related neurons in the DMV. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5525772 Wed, 21 Dec 2011 05:00:00 +0100 5525772 http://www.medworm.com/index.php?rid=5525771&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01846.x Conclusions & Inferences  Accommodation of intra‐abdominal loads involves a volume‐related integrated abdomino‐thoracic response regardless of the expansion rate. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5525771 Wed, 21 Dec 2011 05:00:00 +0100 5525771 http://www.medworm.com/index.php?rid=5495355&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01825.x Conclusions & Inferences  A simple vaginal hysterectomy has relatively modest effects (i.e., somewhat reduced rectal urgency and increased stiffness during rapid distention) on rectal sensorimotor functions. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5495355 Mon, 12 Dec 2011 05:00:00 +0100 5495355 http://www.medworm.com/index.php?rid=5495354&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01827.x Conclusions & Inferences  It is concluded that (i) AME exerts a direct spasmogenic effect on gastric antrum; (ii) choline is the chemical ingredient responsible of such effect; (iii) the prokinetic effect of AME observed in vivo could provide the pharmacological basis underlying its traditional use in the treatment of dyspepsia. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5495354 Mon, 12 Dec 2011 05:00:00 +0100 5495354 http://www.medworm.com/index.php?rid=5495356&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01841.x Conclusions & Inferences  This study outlines the down‐regulation of PAR4 in the mast cells of PI‐IBS. It could be of considerable interests in understanding the mechanisms involved in the persistent colonic hypersensitivity and their potential role as therapeutic targets for PI‐IBS. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5495356 Sun, 11 Dec 2011 05:00:00 +0100 5495356 http://www.medworm.com/index.php?rid=5477214&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01826.x Conclusions & Inferences  Lung pepsin cannot predict pathologic reflux in the esophagus, but its correlation with lung inflammation suggests that pepsin may be an important biomarker for reflux‐related lung disease. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5477214 Mon, 05 Dec 2011 05:00:00 +0100 5477214 http://www.medworm.com/index.php?rid=5505858&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01848.x Conclusions & Inferences  Our findings indicate that TRPV1/PAR‐2 expressing primary afferent neurons mediate an extrinsic motor reflex pathway in the colon. These data, coupled with our previous studies, also indicate that the recently described colospinal afferent neurons are nociceptive, suggesting that these neurons may be useful targets for the pharmacological control of pain in diseases such as irritable bowel syndrome. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5505858 Thu, 01 Dec 2011 05:00:00 +0100 5505858 http://www.medworm.com/index.php?rid=5495353&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01845.x Conclusions & Inferences  Dyspepsia‐GER overlap is common in the population and is greater than expected by chance. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5495353 Thu, 01 Dec 2011 05:00:00 +0100 5495353 http://www.medworm.com/index.php?rid=5477213&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01842.x Conclusions & Inferences  Non‐tasters are more susceptible to vection‐induced motion sickness and nausea than T or ST, suggesting these two traits may have co‐evolved in a reciprocal manner: in environments where the NT trait conferred an evolutionary advantage by enabling intake of fruits and vegetables containing bitter, yet beneficial, phytonutrients, increased nausea susceptibility may have arisen to maintain protection against ingested toxins. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5477213 Thu, 01 Dec 2011 05:00:00 +0100 5477213 http://www.medworm.com/index.php?rid=5458635&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01840.x Conclusions & Inferences  Water avoidance‐stress leads to persistent mast cell dependent visceral hypersensitivity in maternally separated rats, which can be prevented, but not reversed by blockade of peripheral CRF‐receptors. We conclude that persistent poststress mast cell activation and subsequent visceral hypersensitivity are not targeted by CRF‐receptor antagonists. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5458635 Thu, 01 Dec 2011 05:00:00 +0100 5458635 http://www.medworm.com/index.php?rid=5458636&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01823.x Conclusions & Inferences  With appropriate methodology, abnormal intestinal motility can be demonstrated in a significant proportion of patients with functional bowel disorders, implying a pathologic disturbance of gut physiology. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5458636 Wed, 30 Nov 2011 05:00:00 +0100 5458636 http://www.medworm.com/index.php?rid=5458637&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01820.x Conclusions & Inferences  Mast cell activation during abdominal surgery causes epithelial barrier dysfunction and inflammation of the muscularis externa of the bowel. The impairment of the epithelial barrier likely contributes to the pathogenesis of POI. Our data further underscore that mast cells are bona fide cellular targets to ameliorate POI. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5458637 Tue, 29 Nov 2011 05:00:00 +0100 5458637 http://www.medworm.com/index.php?rid=5449985&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01828.x Conclusions & Inferences  Nausea and vomiting are significant symptoms of gastroparesis. Vomiting was greater in DG compared with IG, both in terms of severity score and number of vomiting episodes, whereas nausea severity was similar. Hours of nausea per day and episodes of vomiting per week appear to be useful parameters for assessing symptoms of gastroparesis. Nausea and vomiting have a significant impact on quality of life. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5449985 Mon, 28 Nov 2011 09:17:03 +0100 5449985 http://www.medworm.com/index.php?rid=5449986&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01824.x Conclusions & Inferences  Our data demonstrate that intestinal inflammation triggers a vagally mediated circuit leading mainly to activation of vagal motor neurons connected to the inflamed intestine. These findings for the first time provide neuro‐anatomical evidence for the existence of the endogenous ‘inflammatory reflex’ and its activation during inflammation. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5449986 Sun, 27 Nov 2011 05:00:00 +0100 5449986 http://www.medworm.com/index.php?rid=5432293&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01813.x Conclusions & Inferences  The satiety drinking test is a potentially useful non‐invasive tool in the investigation of children with FD and obesity. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5432293 Tue, 22 Nov 2011 09:08:16 +0100 5432293 http://www.medworm.com/index.php?rid=5432294&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01812.x Conclusions & Inferences  The original criteria for the definition of TLESRs allows for substantial inter‐ and intra‐observer variability, which can be reduced by incorporation of additional objective criteria. However, the highest level of intra‐observer agreement can be achieved by consensus analysis. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5432294 Mon, 21 Nov 2011 05:00:00 +0100 5432294 http://www.medworm.com/index.php?rid=5432296&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01819.x Conclusions & Inferences  Methane delayed ileal peristaltic conduction velocity by augmenting contractility. Hydrogen shortened colonic transit, and that effect was more prominent in the proximal colon than distal colon. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5432296 Sun, 20 Nov 2011 05:00:00 +0100 5432296 http://www.medworm.com/index.php?rid=5432295&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01822.x Conclusions & Inferences  Slow postprandial MCTT in response to a physiological meal does not revert to normal during GFD, an effect mirroring incomplete histopathologic recovery. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5432295 Sun, 20 Nov 2011 05:00:00 +0100 5432295 http://www.medworm.com/index.php?rid=5422925&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01808.x AbstractThere is still no agreement over optimal pharmacological treatment for irritable bowel syndrome (IBS). Patients with IBS and diarrhea (IBS‐D) demonstrate both visceral hypersensitivity and impaired colonic motility with increased frequency and amplitude of giant migrating contractions (GMCs) which cause mass movements, propulsion of stools and initiation of defecation. Both antispasmodics and 5‐HT3 receptor antagonists can improve the symptoms and the impaired colonic motility of patients with IBS‐D though through very different mechanisms. Antispasmodics act by directly relaxing the colonic smooth muscle cells or antagonizing the excitatory neuromuscular neurotransmission. In contrast, the mechanism of action of 5HT3 antagonists is much more complex and subtle as they inhibi... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5422925 Sat, 19 Nov 2011 09:30:09 +0100 5422925 http://www.medworm.com/index.php?rid=5422923&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01821.x Conclusions & Inferences  The outcomes suggest that both conventional and novel PKC isozymes contribute to the phasic and tonic contractile components of BALB/c colonic circular smooth muscle under normal conditions, with novel PKC isozymes having a greater contribution to the tonic contraction. However, no effect of inflammation was observed on the relative contribution of PKC and CPI‐17 toward the observed hypercontractility. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5422923 Sat, 19 Nov 2011 09:29:39 +0100 5422923 http://www.medworm.com/index.php?rid=5422924&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01818.x Conclusions & Inferences  This study demonstrated a marked loss of noradrenergic and sensory nerve fibers in polyp mucosa, which was associated with a strong increase of semaphorin 3F and 3A. Up‐regulation of the sympathetic repellent semaphorin 3F in the polyps possibly triggers sympathetic repulsion and polyp growth due to the loss of anti‐proliferative noradrenaline and presence of SP from local SP+ cells. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5422924 Wed, 16 Nov 2011 05:00:00 +0100 5422924 http://www.medworm.com/index.php?rid=5409343&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01810.x Conclusions & Inferences  Gastrocolonic response at the ICJ may require both intrinsic and extrinsic innervation. When ID was performed, CMMC ratio increased. As a result, intraluminal water absorption may have decreased. ID may be one of the causes of diarrhea after ICR. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5409343 Mon, 14 Nov 2011 05:00:00 +0100 5409343 http://www.medworm.com/index.php?rid=5401260&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01816.x Conclusions & Inferences  Our study demonstrates the feasibility of prolonged ambulatory HRM recordings. Similar to a complete TLESR, longitudinal muscle contraction of the distal esophagus occurs during incomplete TLESRs, which can be detected by the HRM. Using prolonged ambulatory HRM, future studies may investigate the temporal correlation between abnormal longitudinal muscle contraction and esophageal symptoms. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5401260 Thu, 10 Nov 2011 05:00:00 +0100 5401260 http://www.medworm.com/index.php?rid=5401259&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01806.x Conclusions & Inferences  ICC‐IM significantly contributes to the electrical events underlying nitrergic and cholinergic NMT, whereas contractile events persist in the absence of ICC‐IM. The purinergic inhibitory neural pathway appears to be independent of ICC‐IM. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5401259 Thu, 10 Nov 2011 05:00:00 +0100 5401259 http://www.medworm.com/index.php?rid=5388352&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01809.x Conclusions & Inferences  We established rat models to evaluate the effect of gastric acid hypersecretion on gastric emptying and the GD‐induced pain response. In these models, acid hypersecretion delayed gastric emptying and aggravated the pain response. Furthermore, we showed that famotidine ameliorated both delayed gastric emptying and gastric hypersensitivity, whereas mosapride only improved delayed gastric emptying. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5388352 Tue, 08 Nov 2011 05:00:00 +0100 5388352 http://www.medworm.com/index.php?rid=5388353&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01804.x Conclusions & Inferences  Elevated Prok2 levels, as a consequence of gastrointestinal tract inflammation, induce visceral pain via prokineticin receptors. This observation, together with the finding that PROK2 can modulate intestinal ion transport, raises the possibility that inhibitors of PROK2 signaling may have clinical utility in gastrointestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5388353 Thu, 03 Nov 2011 04:00:00 +0100 5388353 http://www.medworm.com/index.php?rid=5388354&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01802.x Conclusions & Inferences  Postprandial barostat measurement enhances visceroperception in IBS but has no added value to detect visceral hypersensitivity in individual IBS patients. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5388354 Wed, 02 Nov 2011 04:00:00 +0100 5388354 http://www.medworm.com/index.php?rid=5409342&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01811.x Conclusions & Inferences  Our study, for the first time, demonstrates that the altered vagally mediated physiology of acid secretion in depression‐prone FSL rats contributes to gastric hypersecretion and, consequently, results in exacerbated stress and NSAID‐induced gastric damage. Flinders rats may be a useful animal model for studying acid‐related and also gastrointestinal functional disorders in depression. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5409342 Tue, 01 Nov 2011 04:00:00 +0100 5409342 http://www.medworm.com/index.php?rid=5401258&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01807.x Conclusions & Inferences  These results indicate that the anti‐motility effects of G. buchananii aqueous extract are potentially mediated by compounds that affect 5‐HT3 and 5‐HT4 receptors. Identification and characterization of the bioactive compounds within G. buchananii could lead to the discovery of new non‐opiate anti‐diarrhea formulations. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5401258 Tue, 01 Nov 2011 04:00:00 +0100 5401258 http://www.medworm.com/index.php?rid=5388355&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01805.x Conclusions & Inferences  The antinociceptive effect of PAR‐4‐AP depends on its penetration to the colonic mucosa. The PAR‐4 activation is endogenously involved as a feedback loop to attenuate inflammatory colonic hyperalgesia to CRD. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5388355 Tue, 01 Nov 2011 04:00:00 +0100 5388355 http://www.medworm.com/index.php?rid=5388351&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01803.x Conclusions & Inferences  The mucosa‐associated microbiota in patients with IBS is significantly different from healthy controls with increases in bacteroides and clostridia and a reduction in bifidobacteria in patients with IBS‐D. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5388351 Tue, 01 Nov 2011 04:00:00 +0100 5388351 http://www.medworm.com/index.php?rid=5362344&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01801.x Conclusions & Inferences  The results indicate that motilin directly stimulates and modulates suncus gastric contraction through cholinergic, adrenergic, serotonergic, opioidergic, and NO neurons in the myenteric plexus. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5362344 Tue, 01 Nov 2011 04:00:00 +0100 5362344 http://www.medworm.com/index.php?rid=5362345&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01797.x Conclusions & Inferences  The mouse esophagus is endowed with a rich serotonin‐positive intrinsic innervation, including enteric co‐innervation of striated muscles. Serotonin may modulate vagal motor innervation of esophageal‐striated muscles not only at the central level via projections of the raphe nuclei to the nucleus ambiguus but also at the peripheral level via enteric co‐innervation. In addition, mast cells represent a non‐neuronal source of serotonin, being involved in neuroimmune processes. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5362345 Thu, 27 Oct 2011 04:00:00 +0100 5362345 http://www.medworm.com/index.php?rid=5324511&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01799.x Conclusions & Inferences  In conclusion, receptor stimulation increases the Ca2+ sensitivity of contractile elements through CPI‐17 phosphorylation via the PKC/ROCK pathways and MYPT1 phosphorylation via the ROCK pathway, when these mechanisms operate cooperatively and/or synchronously in intestinal smooth muscle. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5324511 Tue, 18 Oct 2011 10:16:57 +0100 5324511 http://www.medworm.com/index.php?rid=5324512&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01789.x Conclusions & Inferences  We suggest that orexin‐A and glucose effects on the PVN stimulate gastric acid secretion. This stimulatory effect is probably mediated by orexin‐1 receptors. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5324512 Mon, 17 Oct 2011 04:00:00 +0100 5324512 http://www.medworm.com/index.php?rid=5316171&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01798.x Conclusions & Inferences  Chronic ROSI treatment reverses increased SHR duodenal inhibitory response acting on CO and NO components. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5316171 Sat, 15 Oct 2011 08:46:07 +0100 5316171 http://www.medworm.com/index.php?rid=5305090&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01775.x AbstractIrritable bowel syndrome (IBS) is a common health issue that is characterized by abdominal pain, abnormal bowel movements, and altered visceral perception. The complexity and variability in symptoms pose serious challenges in treating IBS. Current therapy for IBS is primarily focused on reducing the abdominal pain, thereby improving the quality of life to a significant extent. Although the use of fiber rich diet is widely recommended in treating IBS, some studies have questioned its use. Intra‐colonic butyrate, a short‐chain fatty acid, is primarily produced by the fermentation of dietary fibers in the colon. In the existing literature there are conflicting reports about the function of butyrate. In rats it is known to induce visceral hypersensitivity without altered pathology,... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5305090 Wed, 12 Oct 2011 08:20:15 +0100 5305090 http://www.medworm.com/index.php?rid=5305088&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01800.x Conclusions & Inferences  Quantitative analysis of impedance‐pH parameters added to symptom‐reflux association allows a subdivision of refractory‐heartburn patients into refractory NERD and FH which is substantiated by pathophysiological findings and which restricts the diagnosis of FH to one third of cases. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5305088 Wed, 12 Oct 2011 08:19:51 +0100 5305088 http://www.medworm.com/index.php?rid=5305089&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01796.x Conclusions & Inferences  In this colitis model, anxiety‐like behavior is vagally mediated. The anxiolytic effect of B. longum requires vagal integrity but does not involve gut immuno‐modulation or production of BDNF by neuronal cells. As B. longum decreases excitability of enteric neurons, it may signal to the central nervous system by activating vagal pathways at the level of the enteric nervous system. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5305089 Tue, 11 Oct 2011 04:00:00 +0100 5305089 http://www.medworm.com/index.php?rid=5261497&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01791.x Conclusions & Inferences  Cyclic vomiting syndrome (vs FV) was not associated with clinical factors, but was associated with younger age, male gender and cannabinoid use. A larger proportion of CVS (vs IBS) patients had used cannabinoids. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5261497 Thu, 29 Sep 2011 08:09:10 +0100 5261497 http://www.medworm.com/index.php?rid=5261501&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01788.x Conclusions & Inferences  Hs‐CRP levels are higher in IBS patients than HC, but still in the normal laboratory range. This may reflect the low‐grade gut inflammation believed to occur in IBS and support its existence. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5261501 Mon, 26 Sep 2011 04:00:00 +0100 5261501 http://www.medworm.com/index.php?rid=5261500&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01793.x Conclusions & Inferences  Despite the small sample size and the possibility of a false positive finding, our preliminary data support the hypothesis that the T allele of the c‐kit rs6554199 polymorphism may be associated with achalasia in the Turkish population. These findings need to be replicated in other racial‐ethnically diverse populations. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5261500 Mon, 26 Sep 2011 04:00:00 +0100 5261500 http://www.medworm.com/index.php?rid=5261499&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01794.x AbstractBackground  Neurodegenerative diseases may extend outside the central nervous system (CNS) and involve the gastrointestinal (GI) tract. The gut would appear to be a pathological marker for neurodegeneration, as well as a site for studying the pathophysiology of neurodegeneration. In fact, both in the ENS and CNS, misfolded proteins are likely to initiate a process of neurodegeneration. For example, the very same protein aggregates can be detected both in the ENS and CNS. In both systems, misfolded proteins are likely to share common cell‐to‐cell diffusion mechanisms, which may occur through a parallel prion‐like diffusion process. Independently from the enteric or central origin, misfolded proteins may proceed along the following steps, they: (i) form aggregates; (ii) are e... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5261499 Mon, 26 Sep 2011 04:00:00 +0100 5261499 http://www.medworm.com/index.php?rid=5261498&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01795.x Conclusions & Inferences  The proposed region‐growing algorithm provides an automated method to calculate DCI that limits inclusion of vascular pressure artifacts and minimizes the need for user input in data analysis. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5261498 Mon, 26 Sep 2011 04:00:00 +0100 5261498 http://www.medworm.com/index.php?rid=5251351&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01792.x Conclusions & Inferences  These results further suggest a subclinical inflammatory component underlying IBS. To better understand the phenotypic differences in IBS it is important to broaden the study of these inflammatory and other biomarkers. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5251351 Sun, 25 Sep 2011 21:01:59 +0100 5251351 http://www.medworm.com/index.php?rid=5261503&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01782.x Conclusions & Inferences  Our study proves that the PRM is responsible for the closure of the cranial part of anal canal. HDAM, in addition to measuring constrictor function can also record the elevator function of levator ani/pelvic floor muscles. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5261503 Sun, 25 Sep 2011 04:00:00 +0100 5261503 http://www.medworm.com/index.php?rid=5261502&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01784.x Conclusions & Inferences  These data demonstrate significant movement artifacts in extracellular recordings of biopotentials from murine gastric muscles and suggest that movement suppression should be an obligatory control when monitoring electrical activity and characterizing propagation and coordination of electrical events with extracellular recording techniques. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5261502 Sun, 25 Sep 2011 04:00:00 +0100 5261502 http://www.medworm.com/index.php?rid=5238798&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01790.x Conclusions & Inferences  In conclusion, PPGAP is present in a minority of patients after distal gastrectomy; this finding may suggest that the gastric antrum may play a role in the genesis of the PPGAP. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5238798 Thu, 22 Sep 2011 10:03:14 +0100 5238798 http://www.medworm.com/index.php?rid=5238799&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01787.x Conclusions & Inferences  Shift in contractile vigor to the third peristaltic segment may be seen in acid sensitive subjects. HRM characteristics of smooth muscle contraction segments are of value in making this determination. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5238799 Mon, 19 Sep 2011 04:00:00 +0100 5238799 http://www.medworm.com/index.php?rid=5226920&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01778.x Conclusions & Inferences  The results provide evidence that oxidative stress is the common factor in the development of neuronal changes in diabetes; however, the mechanism by which oxidative stress occurs depends on the individual subpopulation of myenteric neurons examined. The presence of calbindin appears to protect myenteric neurons against harmful stimuli. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5226920 Mon, 19 Sep 2011 01:26:09 +0100 5226920 http://www.medworm.com/index.php?rid=5226919&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01776.x Conclusions & Inferences  Lubiprostone has no effect on visceral sensory thresholds. The reductions in clinical pain that occur while taking lubiprostone appear to be secondary to changes in stool consistency. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5226919 Mon, 19 Sep 2011 01:26:03 +0100 5226919 http://www.medworm.com/index.php?rid=5226918&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01774.x AbstractGenome wide association studies and meta‐analyses identified risk factors related to epithelial integrity of the intestinal barrier, innate immune responses and autophagy in inflammatory bowel disorder (IBD) and celiac disease. Irritable bowel syndrome (IBS), the most common functional gastrointestinal disorder (FGID), coexists and shares common, although milder, features with IBD and celiac disease. Although our knowledge on genetic variability in IBS symptom generation is very limited, smaller scale studies attempt to provide insight in the mechanisms underlying IBS. Camilleri et al. identified associations for susceptibility loci in inflammatory and epithelial barrier genes with colonic transit in lower FGID. Their report is the first descriptive study to assess potential gen... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5226918 Mon, 19 Sep 2011 01:25:52 +0100 5226918 http://www.medworm.com/index.php?rid=5226914&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01771.x Conclusions & Inferences  Ramosetron 5 μg once daily is as effective as mebeverine three times daily in male patients with IBS‐D. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5226914 Mon, 19 Sep 2011 01:25:24 +0100 5226914 http://www.medworm.com/index.php?rid=5226916&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01783.x Conclusions & Inferences   Chronic idiopathic intestinal pseudo‐obstruction and SFGIDs are frequently associated with small bowel dysmotility and marked derangements of QoL which are significantly more severe than in IBS and result particularly in being severe in patients with recurrent sub occlusive episodes or inability to maintain a normal body weight. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5226916 Wed, 14 Sep 2011 04:00:00 +0100 5226916 http://www.medworm.com/index.php?rid=5226915&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01785.x Conclusions & Inferences  Opposite autonomic patterns were found in AN and IBS: stronger vagal withdrawal in IBS and weaker vagal inhibition in AN patients. Records made at rest and without any autonomic load may be representative for assessment of ANS function. Age and BMI should be taken into consideration during assessment of HRV data. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5226915 Wed, 14 Sep 2011 04:00:00 +0100 5226915 http://www.medworm.com/index.php?rid=5226917&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01786.x Conclusions & Inferences  High waist hip ratio, triglyceride, fasting blood glucose, and metabolic syndrome were associated with increased risk factors for reflux esophagitis while high high‐density lipoprotein for men correlated with a reduced risk of reflux esophagitis. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5226917 Tue, 13 Sep 2011 04:00:00 +0100 5226917 http://www.medworm.com/index.php?rid=5196929&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01770.x Conclusions & Inferences  The results are consistent with lower potency for agonists at the dog motilin receptor, compared with humans. They also define the doses of GSK962040 which stimulate gastric motility. Correlation of in vivo and in vitro data in the same species, together with plasma concentrations, guides further studies and translation to other species. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5196929 Sun, 04 Sep 2011 23:00:00 +0100 5196929 http://www.medworm.com/index.php?rid=5196931&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01773.x Conclusions & Inferences  We provide an optical approach to improve the imaging depth in 3‐D neurohistology of the human ileum. This methodology has significant promise in facilitating our understanding of the enteric nervous system in health and disease. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5196931 Sat, 03 Sep 2011 23:00:00 +0100 5196931 http://www.medworm.com/index.php?rid=5196930&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01780.x AbstractNitric oxide (NO), produced by the neural nitric oxide synthase enzyme (nNOS) is a transmitter of inhibitory neurons supplying the muscle of the gastrointestinal tract. Transmission from these neurons is necessary for sphincter relaxation that allows the passage of gut contents, and also for relaxation of muscle during propulsive activity in the colon. There are deficiencies of transmission from NOS neurons to the lower esophageal sphincter in esophageal achalasia, to the pyloric sphincter in hypertrophic pyloric stenosis and to the internal anal sphincter in colonic achalasia. Deficits in NOS neurons are observed in two disorders in which colonic propulsion fails, Hirschsprung’s disease and Chagas’ disease. In addition, damage to NOS neurons occurs when there is stress to cell... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5196930 Sat, 03 Sep 2011 23:00:00 +0100 5196930 http://www.medworm.com/index.php?rid=5209825&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01781.x Conclusions & Inferences  Our results suggest that the GNβ3 825CC genotype is significantly associated with PDS patients without gastro‐esophageal reflux with impairments of gastric emptying and also with the feeling of hunger in patients with FD. Further studies are needed to clarify whether the GNβ3 825CC genotype is linked to disturbances of gastric emptying via altered signal transduction responses. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5209825 Thu, 01 Sep 2011 04:00:00 +0100 5209825 http://www.medworm.com/index.php?rid=5196928&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01777.x Conclusions & Inferences Trichinella spiralis infection in rats, at late stages, results in persistent postinfectious intestinal barrier dysfunctions and mucosal mastocytosis, with other signs suggestive of a low grade inflammation. The altered permeability and the TTX‐independent hyporesponsiveness to 5‐HT and IgE indicate epithelial alterations. Changes in responses to SP and capsaicin after neuronal blockade suggest an ENS remodeling during this phase. Similar long‐lasting neuro‐epithelial alterations might contribute to the pathophysiology of functional and postinfectious gastrointestinal disorders. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5196928 Wed, 31 Aug 2011 23:00:00 +0100 5196928 http://www.medworm.com/index.php?rid=5184743&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01779.x Conclusions & Inferences  Nearly 10% of patients with an intestinal bacterial infection report postinfectious symptoms up to 10 years after the infectious event. They represent a clinically important population with high psychiatric comorbidity and somatic symptom burden. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5184743 Wed, 31 Aug 2011 23:00:00 +0100 5184743 http://www.medworm.com/index.php?rid=5163015&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01768.x Conclusions & Inferences  We conclude that the TRPA1 agonists are substantially more effective activators of the placodes‐derived than the neural crest‐derived esophageal nociceptors. Our data predict that in esophageal diseases the presence of endogenous TRPA1 activators will be preferentially signaled by the vagal nodose nociceptors. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5163015 Sat, 27 Aug 2011 16:01:42 +0100 5163015 http://www.medworm.com/index.php?rid=5163017&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01769.x Conclusions & Inferences  Organ‐specific mechanisms involving the MLCP interacting proteins LZ +/− MYPT1, M‐RIP, and CPI‐17 are critical to regulating basal LC20 phosphorylation in gastrointestinal smooth muscles. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5163017 Tue, 23 Aug 2011 23:00:00 +0100 5163017 http://www.medworm.com/index.php?rid=5163016&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01772.x Conclusions & Inferences  Variation in TGR5 may contribute to altered SBT and colonic transit in lower FGID. Further studies are required to characterize the potential role of BA receptor, TGR5, in the mechanism and treatment of bowel dysfunction in lower FGID. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5163016 Tue, 23 Aug 2011 23:00:00 +0100 5163016 http://www.medworm.com/index.php?rid=5163019&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01766.x Conclusions & Inferences  Half of functional dyspepsia patients had chemical hypersensitivity, determined with an oral capsaicin load. Placebo response was negligible. The results of the capsaicin test were not associated with specific dyspepsia symptoms or Rome subgroups. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5163019 Mon, 22 Aug 2011 23:00:00 +0100 5163019 http://www.medworm.com/index.php?rid=5163018&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01767.x Conclusions & Inferences  Acid‐sensitive TRPV4 channels were mainly expressed in the esophageal epithelial cells of the basal and intermediate layers. Direct exposure of TRPV4‐expressing cells to gastric acid, as would occur in cases of GERD, could influence their cellular functions, possibly aggravating the disease state. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5163018 Mon, 22 Aug 2011 23:00:00 +0100 5163018 http://www.medworm.com/index.php?rid=5163020&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01765.x Conclusions & Inferences  Altered protein distributions together with down‐regulation of VMAT1 suggest that chlamydial infection may influence vesicular transport. It is therefore possible that such an infection in vivo could lead to disturbances in the regulation of gut functions. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5163020 Sat, 20 Aug 2011 23:00:00 +0100 5163020 http://www.medworm.com/index.php?rid=5144700&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01764.x AbstractBackground  The vagus nerve is the major neural connection between the gastrointestinal tract and the central nervous system. During fetal development, axons from the cell bodies of the nodose ganglia and the dorsal motor nucleus grow into the gut to find their enteric targets, providing the vagal sensory and motor innervations respectively. Vagal sensory and motor axons innervate selective targets, suggesting a role for guidance cues in the establishment of the normal pattern of enteric vagal innervation.Purpose  This review explores known molecular mechanisms that guide vagal innervation in the gastrointestinal tract. Guidance and growth factors, such as netrin‐1 and its receptor, deleted in colorectal cancer, extracellular matrix molecules, such as laminin‐111, and membe... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5144700 Sat, 20 Aug 2011 16:32:56 +0100 5144700 http://www.medworm.com/index.php?rid=5144701&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01751.x Conclusions & Inferences  Calcium‐linked chloride secretion is disturbed in children with FC. Whether this defect occurs at the level of histamine receptors, components of receptor‐linked signal transduction pathways or basolateral Ca2+‐sensitive K+ channels enhancing the electrical driving force for apical chloride secretion, remains to be explored. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5144701 Tue, 16 Aug 2011 23:00:00 +0100 5144701 http://www.medworm.com/index.php?rid=5132787&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01747.x Conclusions & Inferences  Posterior fossa stimulation excites the cerebellum and evokes direct motor responses within the pharynx. When conditioned with TMS, the cerebellum strongly facilitates the cortical swallowing motor pathways. This finding suggests that the cerebellum exerts a modulatory effect on human swallowing and raises the possibility that excitatory neurostimulation of the cerebellum may be therapeutically useful in promoting recovery of dysphagia after neural damage. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5132787 Tue, 16 Aug 2011 22:23:12 +0100 5132787 http://www.medworm.com/index.php?rid=5132786&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01756.x AbstractThe stomach is electrified and subject to eurhythmic and dysrhythmic electrical events – much like the heart. The normal human slow wave ranges from 2.5 to 3.75 cycles per min (cpm), tachygastrias range from 3.75 cpm to 10.0 cpm and bradygastrias from .5 to 2.5 cpm, the gastric dysrhythmias of men and women. In this issue of Neurogastroenterology & Motility, O’Grady, et al. describe the gastric dysrhythmias of pigs in electrocardiology terms. Printed circuit boards (PCB) with multi‐electrode arrays (160–192 electrodes) were attached to the stomach serosa. Gastric dysrhythmias occurred in eight of the 16 anesthetized pigs and were analysed by manually and by computer. The patterns of dysrhythmias were reminiscent of cardiac dysrhythmias: conduction blocks, ectopic... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5132786 Tue, 16 Aug 2011 22:23:03 +0100 5132786 http://www.medworm.com/index.php?rid=5132785&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01762.x (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5132785 Tue, 16 Aug 2011 22:22:55 +0100 5132785 http://www.medworm.com/index.php?rid=5132784&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01755.x (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5132784 Tue, 16 Aug 2011 22:22:43 +0100 5132784 http://www.medworm.com/index.php?rid=5110440&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01763.x Conclusions & Inferences  Results show developmental changes in infant swallow physiology that can be clearly linked to the effectiveness of nutritive swallowing. Most preterm infants demonstrated poor pharyngeal pressures at the laryngeal inlet coupled with poor coordination of pharyngeal propulsion with UES relaxation. These pressure patterns were less efficient than those demonstrated by older infants who were more adept at feeding. These observations may explain why infants under 34 weeks are physiologically unable to feed effectively and experience frequent choking and fatigue during feeding. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5110440 Sun, 31 Jul 2011 23:00:00 +0100 5110440 http://www.medworm.com/index.php?rid=5098508&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01761.x Conclusions & Inferences  Our findings are consistent with previous reports of improved maintenance of brain stem cells cultured under reduced oxygen stress conditions and may therefore be applied to future cell culture protocols in ENS stem cell research. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5098508 Sun, 31 Jul 2011 23:00:00 +0100 5098508 http://www.medworm.com/index.php?rid=5089033&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01754.x Conclusions & Inferences  Two‐channel gastric pacing is a novel treatment approach which is able to normalize and enhance gastric slow wave activity as well as accelerate gastric emptying in patients with diabetic gastroparesis with a goal safety profile. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5089033 Sun, 31 Jul 2011 23:00:00 +0100 5089033 http://www.medworm.com/index.php?rid=5089032&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01760.x Conclusions & Inferences  Histamine receptor expression in simian SMC was similar to that reported in humans. However, H receptor profile and responses to H were considerably different in mice. Thus, monkey colon may be a more suitable model to study how inflammatory mediators affect the gain of smooth muscle excitability. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5089032 Sun, 31 Jul 2011 23:00:00 +0100 5089032 http://www.medworm.com/index.php?rid=5053543&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01753.x Conclusions & Inferences  Pacemaker ICC play a prominent role in the expression of motor activity induced by cholinergic activity and our data suggest that cholinergic neurotransmission to ICC affects the pacemaker frequency. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5053543 Sat, 23 Jul 2011 17:00:49 +0100 5053543 http://www.medworm.com/index.php?rid=5040607&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01748.x Conclusions & Inferences  Our data provide the first evidence that human EGCs directly respond to pro‐inflammatory stimuli by changing their expression profile and by proliferating. The finding that stimulated EGCs are able to produce NO points to a role of this cell population in the scenario of intestinal inflammation. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5040607 Wed, 20 Jul 2011 17:49:20 +0100 5040607 http://www.medworm.com/index.php?rid=5031132&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01722.x (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5031132 Sat, 16 Jul 2011 17:05:22 +0100 5031132 http://www.medworm.com/index.php?rid=5031131&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01752.x AbstractChronic constipation (CC) is widely prevalent in the Western world, with a significant negative impact on quality of life, yet new and effective pharmacological and non‐pharmacological treatment options have only recently emerged. The article by Tack and colleagues in the current issue of NGM is timely with the recent introduction of the serotonin type 4 receptor agonist prucalopride in Europe and wider acceptance of anorectal biofeedback for patients with pelvic floor dyssynergia. This Editorial (i) highlights the importance of identifying patients with pelvic floor dysfunction who are candidates for pelvic floor retraining programs and (ii) discusses the potential limitations of the 5‐HT4 agonist, prucalopride, as an early option in the treatment algorithm for CC. (Source: Ne... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5031131 Sat, 16 Jul 2011 17:05:14 +0100 5031131 http://www.medworm.com/index.php?rid=5031129&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01749.x Conclusions & Inferences  Genetic variations that may influence local mucosal immune functions are univariately associated with altered colonic transit in lower FGID. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5031129 Sat, 16 Jul 2011 17:05:03 +0100 5031129 http://www.medworm.com/index.php?rid=5031130&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01750.x Conclusions & Inferences  The present findings indicate that the GLP‐2R is expressed by inhibitory and excitatory neurons, the GLP‐2 inhibits the muscle contractility likely decreasing cholinergic neurotransmission and increasing nitric oxide production, and this effect is possibly mediated by the ICC‐DMP recruitment. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5031130 Tue, 12 Jul 2011 23:00:00 +0100 5031130 http://www.medworm.com/index.php?rid=5021591&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01746.x Conclusions & Inferences  Dyspepsia‐related consultation varied significantly between urban and rural communities. Factors within the rural population, self‐medication practices, and a low quality of life independently influenced dyspepsia‐related consultation. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5021591 Sun, 10 Jul 2011 23:00:00 +0100 5021591 http://www.medworm.com/index.php?rid=4999805&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01745.x Conclusions & Inferences  The faster puller speed has improved agreement between vector profiles, which is most marked during active contraction. The 8‐channel catheters have the greatest agreement between profiles. There is variation in values between automated manometry and the stationary pull through technique. The improved repeatability in automated VVM for healthy controls should improve its diagnostic utility in patients with incontinence. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=4999805 Sat, 02 Jul 2011 23:00:00 +0100 4999805 http://www.medworm.com/index.php?rid=5021590&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01743.x Conclusions & Inferences  Gastric MR provides quantitative measurements of postprandial volume change with low IOV, unless the stomach is nearly empty. The novel LinExp model describes the dynamic volume changes in the early postprandial period more accurately than the PowExp model used in existing gastric emptying studies. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=5021590 Thu, 30 Jun 2011 23:00:00 +0100 5021590 http://www.medworm.com/index.php?rid=4999804&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01742.x Conclusions & Inferences  G protein‐coupled receptor 55 existed throughout the whole intestine of rats. O‐1602 or CBD selectively normalized the motility disturbances. Possible mechanisms involved systemic anti‐inflammation and the regulation of myoelectrical activity of the intestine. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=4999804 Thu, 30 Jun 2011 23:00:00 +0100 4999804 http://www.medworm.com/index.php?rid=4986806&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01741.x Conclusions & Inferences  The EAS has two functional classes of mechanoreceptors: slowly adapting low‐threshold and rapidly adapting low‐threshold mechanoreceptors. These two classes of afferents are likely to be involved in the maintenance of continence, and the process of defecation. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=4986806 Thu, 30 Jun 2011 23:00:00 +0100 4986806 http://www.medworm.com/index.php?rid=4986809&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01739.x Conclusions & Inferences  Intraoperative multi‐electrode mapping of fasted weaner healthy pigs detected dysrhythmias in 15% of recordings (from 50% of animals), including patterns not previously reported. The techniques and findings described here offer new opportunities to understand the nature of human gastric dysrhythmias. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=4986809 Wed, 29 Jun 2011 23:00:00 +0100 4986809 http://www.medworm.com/index.php?rid=4986808&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01740.x Conclusions & Inferences  Presence of erosive esophagitis in a subset of Taiwanese patients with healed DU and negative H. pylori status was associated with slower solid phase gastric emptying. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=4986808 Wed, 29 Jun 2011 23:00:00 +0100 4986808 http://www.medworm.com/index.php?rid=4986807&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01744.x Conclusions & Inferences  Higher levels of GnRH IgM antibodies were detected in patients with IBS and dysmotility, but not organic GI diseases, compared with healthy controls. These findings suggest that IBS and dysmotility to some extent may be of an autoimmune origin. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=4986807 Wed, 29 Jun 2011 23:00:00 +0100 4986807 http://www.medworm.com/index.php?rid=4978117&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01738.x AbstractThe lower esophageal sphincters (LES) together with the crural diaphragm are the major antireflux barriers protecting the esophagus from reflux of gastric content. However, reflux of gastric contents into the esophagus is a normal phenomenon in healthy individuals occurring primarily during episodes of transient lower esophageal sphincter relaxation (TLESR), defined as LES relaxation in the absence of a swallow. Transient lower esophageal sphincter relaxation is also the dominant mechanism of pathologic reflux in gastroesophageal reflux disorder (GERD) patients. Frequency of TLESR does not differ significantly between healthy individuals and those with GERD, but TLESRs are more likely to be associated with acid reflux in GERD patients. Understanding the mechanisms responsible for e... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=4978117 Wed, 29 Jun 2011 17:40:53 +0100 4978117 http://www.medworm.com/index.php?rid=4955068&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01735.x Conclusions & Inferences  Our data suggest that BR inhibits intestinal motility – preferentially in pathophysiologic conditions – with a mechanism possibly involving membrane PAR‐2 and PLC and PDE4 as intracellular signals. Bromelain could be a lead compound for the development of new drugs, able to normalize the intestinal motility in inflammation and diabetes. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=4955068 Wed, 22 Jun 2011 17:32:44 +0100 4955068 http://www.medworm.com/index.php?rid=4938439&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01737.x (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=4938439 Sat, 18 Jun 2011 17:19:08 +0100 4938439 http://www.medworm.com/index.php?rid=4938438&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01734.x Conclusions & Inferences  Standardized gastric pain can be conveniently achieved in a majority of healthy subjects using a simple oral capsaicin titration, with minimal adverse events. The between‐test reproducibility is high and nocebo responses are negligible. This technique stimulating a multimodal physiological pathway will be useful in the investigation of sensory changes in FGIDs, including functional dyspepsia. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=4938438 Sat, 18 Jun 2011 17:19:03 +0100 4938438 http://www.medworm.com/index.php?rid=4938437&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01719.x AbstractIntestinal luminal exposure to glucose initiates changes in food intake and gastrointestinal (GI) motor and secretory function. It does this by stimulating the release of GI hormones and 5‐hydroxytryptamine (5‐HT) from enteroendocrine and enterochromaffin cells (EC), respectively, which in turn activate intrinsic and extrinsic neuronal pathways. An article in this issue of the journal provides new insight into the mechanisms involved in luminal glucose sensing. Vincent et al. have used a novel in vivo technique to determine activation of gut epithelial cells and vagal afferent pathways in rats by staining for activated calcium‐calmodulin kinase II (pCaMKII) along the pathway. In the mucosa, they found that intraluminal glucose activated EC cells and brush cells. At the next ... Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=4938437 Sat, 18 Jun 2011 17:18:57 +0100 4938437 http://www.medworm.com/index.php?rid=4886146&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01736.x Conclusions & Inferences  Dynamic NIR fluorescence imaging with injection of ICG can provide a method for diagnostic motility testing for intestinal motility disorders or dysfunction and for potential evaluation of therapeutic agents. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=4886146 Tue, 31 May 2011 23:00:00 +0100 4886146 http://www.medworm.com/index.php?rid=4864945&cid=s_30383_17_f&fid=30383&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1365-2982.2011.01732.x Conclusions & Inferences  Mosapride stimulates colonic motility without any adverse effect. These findings suggest that mosapride may have the potential to treat IBS patients with constipation and/or functional constipation. Further clinical trials are warranted to confirm the efficacy of this agent. (Source: Neurogastroenterology and Motility) Neurogastroenterology and Motility journals http://www.medworm.com/rss/comments.php?id=4864945 Thu, 26 May 2011 17:01:10 +0100 4864945