MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Neurological Sciences' source. Wed, 08 Feb 2012 20:43:29 +0100 http://www.medworm.com/index.php?rid=5668692&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl707282p6642n147%2F Abstract  To observe the effects of minimally invasive procedures for the evacuation of intracerebral hematomas on perihematomal ET-1 expression and their correlation with blood–brain barrier (BBB) permeability. Forty-five rabbits (2.8–3.4 kg body weight) were randomly divided into a normal control group (NC group, 15 rabbits), a model control group (MC group, 15 rabbits) and a minimally invasive group (MI group, 15 rabbits). A model of intracerebral hemorrhage (ICH) was prepared in the MC and MI groups by infusing autologous arterial blood into the rabbits’ brains; the same procedure was also performed in the NC group but without infusing blood into the rabbits’ brains. The intracerebral hematomas were evacuated by a stereotactic procedure in the minimally inv... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5668692 Mon, 06 Feb 2012 19:34:31 +0100 5668692 http://www.medworm.com/index.php?rid=5668693&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F98157qrmnp3j76k4%2F Abstract  A patient self-rated 19-item wearing-off questionnaire (WOQ-19) was shown to be a potent screening tool for wearing-off (WO) in patients with Parkinson’s disease. As part of the early detection of wearing-off in Parkinson’s disease study, we preliminarily performed a linguistic and a psychometric validation of an Italian version of the WOQ-19. Moreover, we assessed the sensitivity and specificity of the WOQ-19 in the office-based settings. The psychometric validation study included assessment of discriminant ability, internal consistency and test–retest reliability. The intraclass correlation coefficient (ICC) and the Cronbach’s Alpha were assessed. The WOQ-19 sensitivity and specificity were calculated in respect to the physician assessment of WO, taken a... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5668693 Fri, 03 Feb 2012 17:53:04 +0100 5668693 http://www.medworm.com/index.php?rid=5668694&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq3884j5826pl4111%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10072-012-0963-7Authors Carlo Civardi, Clinica Neurologica, Azienda Ospedaliera Universitaria “Maggiore della Carità”, C.so Mazzini 18, 28100 Novara, ItalyAlessandra Collini, Department of Neurology, Università del Piemonte Orientale “A. Avogadro”, Novara, ItalyAlessandro Stecco, Department of Radiology, Università del Piemonte Orientale “A. Avogadro”, Novara, ItalyAlessandro Carriero, Department of Radiology, Università del Piemonte Orientale “A. Avogadro”, Novara, ItalyFrancesco Monaco, Department of Neurology, Università del Piemonte Orientale “A. Avogadro”, Novara, Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5668694 Fri, 03 Feb 2012 17:53:03 +0100 5668694 http://www.medworm.com/index.php?rid=5668695&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8410711814475m82%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10072-012-0969-1Authors Xiao-Ke Wang, Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun, ChinaJie Zhu, Department of Neurology, The First Hospital of Jilin University, Jilin University, Changchun, ChinaHong-Liang Zhang, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Karolinska University Hospital Huddinge, Novum, Plan 5, 141 86 Stockholm, Sweden Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5668695 Fri, 03 Feb 2012 17:53:00 +0100 5668695 http://www.medworm.com/index.php?rid=5668696&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff010351717410404%2F We present two cases of the Wernekink commissure syndrome with acute onset of bilateral cerebellar dysfunction confirmed by magnetic resonance imaging. One patient presented internuclear ophthalmoplegia, but neither showed palatal tremor. It is notable that the bilateral cerebellar dysfunction may be ascribed to midbrain lesion involving the Wernekink commissure, and it may be the sole manifestation of the midbrain lesion. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-012-0966-4Authors Huayan Liu, Department of Neurology, First Affiliated Hospital, China Medical University, No.155, North Nanjing Street, 110001 Shenyang, ChinaLei Qiao, Department of General Surgery, Shengjing Hospital, China Medical University, Shenyang, ChinaZhiyi He, Department of N... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5668696 Fri, 03 Feb 2012 17:52:59 +0100 5668696 http://www.medworm.com/index.php?rid=5660876&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fun2803rwm6022371%2F This study investigated the time course expression of Notch 1 and the effects of DAPT on Notch 1 and NF-κB after MCAO. The results showed that Notch 1 signaling was up-regulated at the early stage after MCAO, DAPT down-regulated the expression of Notch 1 and NF-κB and protected brain from damage caused by MCAO. These results may indicate that the downregulation of Notch 1–NF-κB pathway after ischemia by administration of DAPT is a potential mechanism for its protection. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s10072-012-0948-6Authors Shuya Li, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing, 100050 ChinaXiangjian Zhang, Department of Neurology, Second Hospital of H... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5660876 Thu, 02 Feb 2012 18:12:08 +0100 5660876 http://www.medworm.com/index.php?rid=5660877&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq80g63061801n207%2F In conclusion, notwithstanding its limitations, this is the first study to report measurements of carnitine levels in HD patients, revealing relatively high prevalence of hypocarnitinemia in our population. Our findings suggest that HD patients with hypocarnitinemia may benefit from low-dose levocarnitine supplementation. Further studies of carnitine metabolism and supplementation in HD patients are warranted. Content Type Journal ArticleCategory Brief CommunicationPages 1-6DOI 10.1007/s10072-012-0952-xAuthors Miroslav Cuturic, Department of Mental Health, University of South Carolina School of Medicine, Columbia, SC, USARuth K. Abramson, Department of Neuropsychiatry and Behavioral Science, Hall Institute of Psychiatry, University of South Carolina School of Medicine, Columbia, ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5660877 Tue, 31 Jan 2012 16:44:49 +0100 5660877 http://www.medworm.com/index.php?rid=5660879&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy7408g721227826j%2F We report a case of CNS primitive lymphoma in an adult patient who resulted positive for NF1 at genetic testing. At present, only one case of CNS lymphoma in an adult patient displaying clinical criteria for NF1 diagnosis has been reported. Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.1007/s10072-011-0886-8Authors Marica Eoli, Fondazione I.R.C.C.S. Istituto Neurologico C. Besta, Unit of Molecular Neuro-Oncology, Milan, ItalyDonata Bianchessi, Fondazione I.R.C.C.S. Istituto Neurologico Nazionale C. Mondino, Pavia, ItalyAnna Luisa Di Stefano, Fondazione I.R.C.C.S. Istituto Neurologico Nazionale C. Mondino, Pavia, ItalyElena Prodi, Fondazione I.R.C.C.S. Istituto Neurologico Nazionale C. Mondino, Pavia, ItalyElena Anghileri, Fondazione I.R.C.C.S. Istituto Neurologic... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5660879 Tue, 31 Jan 2012 16:44:48 +0100 5660879 http://www.medworm.com/index.php?rid=5660878&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0428146081w85v32%2F Abstract  The aim of this study was to determine the mechanism by which erythropoietin (EPO) suppressed 6-hydroxydopamine (6-OHDA)-induced apoptosis. Our results showed that 6-OHDA remarkably decreased phosphorylation of glycogen synthase kinase 3β (GSK3β) as well as enhanced the level of Bax in the mitochondria. Besides, 6-OHDA decreased the mitochondrial expression of Bcl-2 without altering the cytoplasmic expression of Bcl-2. In line with these results, 6-OHDA treatment enhanced the apoptosis and caspase 3 activity in PC12 cells. These findings indicated that mitochondrial dysfunction was involved in the neurotoxicity of 6-OHDA and GSK3β might act upstream of Bax/Bcl-2 and the caspase 3 pathways in 6-OHDA-treated PC12 cells. Furthermore, EPO reduced 6-OHDA-induced gro... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5660878 Tue, 31 Jan 2012 16:44:48 +0100 5660878 http://www.medworm.com/index.php?rid=5650053&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy653n54717135252%2F Abstract  Migraine patients are particularly prone to develop medication overuse headache (MOH). However, the risk factors for the transformation of migraine to MOH are still not clear. We investigated gene polymorphisms, personality traits, and characteristics of headache and lifestyle in 47 migraine patients (aged 36.4 ± 10.3) and 22 MOH patients (aged 39.6 ± 9.9) who progressed from migraine and made a scoring system for a predictive index (PI) of the onset of MOH in patients with migraine. By multivariate logistic stepwise regression analysis, type of migraine, regular and sufficient dietary intake, and methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) and dopamine D2 receptor (DRD2) C939T (rs6275) polymorphisms were selected as signific... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5650053 Mon, 30 Jan 2012 16:04:43 +0100 5650053 http://www.medworm.com/index.php?rid=5650052&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8473m876k39p2015%2F Content Type Journal ArticlePages 1-1DOI 10.1007/s10072-012-0957-5 Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5650052 Mon, 30 Jan 2012 16:04:43 +0100 5650052 http://www.medworm.com/index.php?rid=5650054&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp25533r543957514%2F Abstract  Brainstem auditory evoked potentials (BAEPs) have been used as a valuable neurophysiologic index of neuronal dysfunction in the level of the brainstem. BAEPs are also useful in subdividing evoked potentials into normal, slight, or pronounced in patients with vertebrobasilar insufficiency. We investigated the changes of BAEP after vertebrobasilar artery ischemia in rabbits and its significance in clinical work. A brainstem ischemic model was made by unilateral extracranial occlusion of vertebral artery to monitor BAEPs at 0, 10, 20, 30, 40, 50, and 60 min after occlusion. We found that peak latencies (PL) of I, III, and most notably V were gradually extended. In addition, we observed a significant (P < 0.05) delay of interpeak latencies (IPL) of wa... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5650054 Mon, 30 Jan 2012 16:04:42 +0100 5650054 http://www.medworm.com/index.php?rid=5650055&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu15g0x1r46h11l17%2F Abstract  Cerebellar mass lesion is an uncommon presentation of toxoplasmosis. The authors report one rare case in an 11-month-old HIV/AIDS female infant who presented with deterioration in her developmental milestones. CT scan revealed a ring-enhancing mass lesion in the right cerebellar hemisphere with secondary obstructive hydrocephalus. A ventriculoperitoneal shunt was inserted prior to posterior fossa decompression and biopsy of the lesion. The specimens obtained were divided into two. One specimen was sent for histological diagnosis immediately after surgery while the second specimen was preserved until the release of the histology report. The initial histopathology report indicated a neoplastic process. Immunohistochemical stains were attempted but interpreted with d... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5650055 Fri, 27 Jan 2012 17:55:44 +0100 5650055 http://www.medworm.com/index.php?rid=5650056&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk4v3001225j5jth5%2F Content Type Journal ArticleCategory Acknowledgements to RefereesPages 1-3DOI 10.1007/s10072-012-0958-4 Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5650056 Wed, 25 Jan 2012 18:11:47 +0100 5650056 http://www.medworm.com/index.php?rid=5650057&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft0v3g7841n2p2015%2F Abstract  Stroke is an enormous public health problem with an imperative need for more effective therapy. Free radicals have been reported to play a role in the expansion of ischemic brain lesions, and the effect of free radical scavengers is still under debate. The present study investigated the neuroprotective effect of Ocimum sanctum (OS) to reduce brain injury after middle cerebral artery occlusion (MCAO). Male Wistar rats were subjected to MCAO for 2 h and reperfused for 22 h. The administration of OS (200 mg/kg bwt., orally) once daily for 15 days before MCAO showed marked reduction in infarct size, reduced the neurological deficits, and suppressed neuronal loss in MCAO rats. A significantly depleted activity of antioxidant enzymes and content of gl... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5650057 Wed, 25 Jan 2012 18:11:46 +0100 5650057 http://www.medworm.com/index.php?rid=5639497&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmn700x062611l672%2F Abstract  Late-onset Krabbe disease may have variable misleading clinical manifestations and be a puzzling problem for physicians. We report clinical and peripheral nerve studies of three patients with adult-onset Krabbe disease. Two cases had a predominantly spastic paraparesis; in one case, the symptoms mimicked a cerebrovascular disorder. Predominantly, demyelinating neuropathy was observed in one case and axonal neuropathy in two cases. In all cases, no typical intracytoplasmic inclusions were found. These observations suggest that peripheral neuropathy in adult-onset Krabbe disease has variable clinical and pathological characteristics, different from those described in the classic form. Content Type Journal ArticleCategory Brief CommunicationPages 1-5DOI 10.1007/s... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5639497 Tue, 24 Jan 2012 12:26:00 +0100 5639497 http://www.medworm.com/index.php?rid=5639496&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fwv7402102346k153%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10072-012-0954-8Authors Rodrigo Alencar, Movement Disorders Unit, Neurology Division, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Av Pasteur 89/1107, Belo Horizonte, MG 30150-290, BrazilSarah Camargos, Movement Disorders Unit, Neurology Division, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Av Pasteur 89/1107, Belo Horizonte, MG 30150-290, BrazilThiago Cardoso, Movement Disorders Unit, Neurology Division, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Av Pasteur 89/1107, Belo Horizonte, MG 30150-290, BrazilDébora Maia, Movement Disorders Unit, Neurology Division, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Av Pasteur 89/1107, Belo H... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5639496 Tue, 24 Jan 2012 12:26:00 +0100 5639496 http://www.medworm.com/index.php?rid=5639498&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft23q075241181584%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-1DOI 10.1007/s10072-012-0951-yAuthors Viroj Wiwanitkit, Wiwanitkit House, Bangkhae, Bangkok, 10160 Thailand Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5639498 Tue, 24 Jan 2012 07:34:40 +0100 5639498 http://www.medworm.com/index.php?rid=5639499&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj53l6653v51129wl%2F Abstract  Restless legs syndrome (RLS) is common in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). A few studies so far have investigated RLS prevalence in ESRD patients undergoing continuous ambulatory peritoneal dialysis (CAPD). The aim of this study was to compare the prevalence, characteristics, consequences and predictors of RLS between HD and CAPD patients. We recruited 58 HD and 28 CAPD patients. A neurologist expert in sleep medicine performed RLS diagnosis during a face-to-face interview. The prevalence of RLS was slightly higher in HD than in CAPD patients (19 vs. 10.7%). RLS appeared after the onset of kidney complaint in HD patients; in contrast, in CAPD patients RLS preceded the occurrence of renal disease. Five HD patients reported that ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5639499 Tue, 24 Jan 2012 07:34:39 +0100 5639499 http://www.medworm.com/index.php?rid=5639501&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1314780x6r4300k1%2F Abstract  Autobiographical memory (ABM) was evaluated in 19 patients with amnestic Mild Cognitive Impairment (aMCI) by means of the standardized enquiry developed by Borrini et al. (Psychol Med 19:215–224, 1989). Longitudinal assessments were carried out by re-testing participants at 9-month intervals up to three assessments over 18 months. Although aMCI patients performed significantly worse than age-, gender- and education-matched normal controls, all of them achieved above normal scores according to Italian norms. No evidence of disproportionate sparing of remote memories (i.e., classical temporal gradient, TG) was found. These findings contrast with the previously reported significant impairment of memory for public events (Bizzozero et al. in J Clin Exp Neuropsyc... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5639501 Tue, 24 Jan 2012 07:34:36 +0100 5639501 http://www.medworm.com/index.php?rid=5639500&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh56m314646887145%2F Abstract  Accurate prediction of epileptic seizures will open novel therapeutic possibilities for patients with intractable epilepsy. We attempted to identify precursors of seizures in the functional networks of electrocorticograms by applying graph theory. Long-term electrocorticograms for periods of 39–76 h from three patients with temporal lobe epilepsy were investigated using pair-wise cross-correlations. Time-varying network properties suggested that there were several distinct brain states. Although functional networks during seizures could be characterized as having a regular topography, no consistent characteristics of functional networks were found immediately prior to seizure onsets. However, it was found that seizures under an identical state were followed... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5639500 Tue, 24 Jan 2012 07:34:36 +0100 5639500 http://www.medworm.com/index.php?rid=5639503&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg10251118u973018%2F Abstract  Deep brain stimulation (DBS) extends the treatment of some severe neurological diseases beyond pharmacological and conservative therapy. Our experience extends the field of DBS beyond the treatment of Parkinson disease and dystonia, including several other diseases such as cluster headache and disruptive behavior. Since 1993, at the Istituto Nazionale Neurologico “Carlo Besta” in Milan, 580 deep brain electrodes were implanted in 332 patients. The DBS targets include Stn, GPi, Voa, Vop, Vim, CM–pf, pHyp, cZi, Nacc, IC, PPN, and Brodmann areas 24 and 25. Three hundred patients are still available for follow-up and therapeutic considerations. DBS gave a new therapeutic chance to these patients affected by severe neurological diseases and in some cases controll... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5639503 Tue, 24 Jan 2012 07:34:35 +0100 5639503 http://www.medworm.com/index.php?rid=5639502&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq12g28w3726ut735%2F In this study, four patients (age range 56–72 years) were treated for intracranial metastases from renal cell carcinoma. The metastasis was solitary in all four patients and was located in the temporoparietal region in two patients, cerebellum in one patient, and bilateral lateral ventricles in one patient. Preoperative magnetic resonance imaging showed hemorrhage and necrosis in the tumor in all four patients, and one patient had edema in the region of the tumor. All patients were treated with craniotomy for tumor resection, and histopathologic examination showed clear cell carcinoma. Marked bleeding occurred in all patients during the operation, but preoperative direct injection of ethanol into epidural metastases (2 patients) was effective in decreasing intraoperative blood... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5639502 Tue, 24 Jan 2012 07:34:35 +0100 5639502 http://www.medworm.com/index.php?rid=5621260&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F877u3v11kx402255%2F In this study, we reviewed studies investigating the characteristics of PM disorders in these individuals and the potential for cognitive rehabilitation. The PM profiles of individuals with MCI and PD indicate that interventions aimed at enhancing the different cognitive processes underlying their PM disorders could be useful. At the current state of the art, however, no evidence-based protocols are available. Therefore, the discussion proposed here should be considered an attempt to identify some valuable perspectives for future research and interventions. Content Type Journal ArticleCategory Review ArticlePages 1-8DOI 10.1007/s10072-012-0935-yAuthors Alberto Costa, IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00179 Rome, ItalyGiovanni Augusto Carlesimo, IRCCS Fondazione Sa... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5621260 Fri, 20 Jan 2012 07:07:39 +0100 5621260 http://www.medworm.com/index.php?rid=5621261&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F74m5671207565628%2F We report the results of the first 5 years of activity. Reasons for patient referral were not only cognitive, language, gait, and psychiatric disturbances related to stroke or chronic CVD, but also neuroimaging evidence of vascular encephalopathy and screening for familial microangiopathies. The patients were evaluated with uniformed protocols. From January 2006 to November 2010, we evaluated 403 patients. Of these, 374 (93%; mean age 69.7 years ± 15.0) were considered appropriate for the VAS-COG clinic. The following diagnoses were made: vascular dementia (8.6%), Alzheimer disease (2.1%), mixed dementia (vascular plus degenerative) (4.8%), vascular mild cognitive impairment (MCI) (9.1%), amnesic-MCI (8.0%), mixed-MCI (4.8%), post-stroke depression (2.7%), post-s... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5621261 Thu, 19 Jan 2012 06:56:25 +0100 5621261 http://www.medworm.com/index.php?rid=5621263&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn3827665314j2278%2F Abstract  The enzyme 5alpha-reductase 1 (5α-R1) that converts testosterone (T) to dihydrotestosterone (DHT) is present in many mammalian tissues including the spinal cord. It is established that morphine administration decreases spinal cord T levels, but the mechanism is still undetermined. Here, we investigated the link between T and the enzyme 5α-R1 in the spinal cord after morphine administration. For spinal cord steroid extraction, all the animals were killed 30 min, 2 h (acute) and 14 days (chronic) after first drug injection by decapitation. The whole spinal cord was removed and kept frozen at −20°C until T and DHT extraction. The effects of acute and chronic morphine administration on 5α-R1 expression in the adult male rat spinal cord were evaluate... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5621263 Thu, 19 Jan 2012 06:56:24 +0100 5621263 http://www.medworm.com/index.php?rid=5621262&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxk8t442757217130%2F This study reports clinical, MRI and outcome of patients with central nervous system (CNS) fungal infections. 39 patients with CNS fungal infections treated in neurology service during the last 3 years were included and a detailed medical history and clinical examination were undertaken. Cranial MRI including paranasal sinuses were carried out and the location and nature of abnormalities were noted. Fungal infection was confirmed by CSF examination or histopathology. Death during hospital stay was noted. The median age was 37 (8–72) years and 8 were females. The clinical features included altered sensorium in 31, focal motor deficits in 13, visual loss in 12, seizures in 10, diplopia in 7, and papilledema in 9 patients. 28 patients had the following predisposing condition... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5621262 Thu, 19 Jan 2012 06:56:24 +0100 5621262 http://www.medworm.com/index.php?rid=5621264&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6jx51850p121p38q%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s10072-012-0947-7Authors Julie Chi Chow, Department of Pediatrics, Chi-Mei Foundation Medical Center, Tainan, TaiwanChin-Wei Huang, Department of Neurology, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan, 704 TaiwanChen-Wen Fang, Department of Neurology, National Taiwan University Hospital, Yun-Lin Branch, Douliou, TaiwanYi-Jen Wu, Department of Pediatrics, Chi-Mei Foundation Medical Center, Tainan, TaiwanJing-Jane Tsai, Department of Pediatrics, Chi-Mei Foundation Medical Center, Tainan, Taiwan Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5621264 Thu, 19 Jan 2012 06:56:23 +0100 5621264 http://www.medworm.com/index.php?rid=5621265&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm203722l645h30r2%2F We describe a 47-year-old woman who presented with palinopsia and subacute altered mental change after cefditoren pivoxil administration. The patient showed characteristic clinical manifestations of hypocarnitinemia, which affected her state of consciousness and she had radiologic findings that revealed metabolic encephalopathy with cytotoxic edema in the right occipital area and intracranial hemorrhages in right occipital and left frontal areas. Follow-up imaging after oral carnitine supplementation demonstrated complete resolution of the bilateral frontal subcortical T2 high-intensity lesions. Carnitine deficiency due to cefditoren pivoxil treatment may present as metabolic encephalopathy in adults. This possibility should be considered with the differential diagnosis of encephalop... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5621265 Thu, 19 Jan 2012 06:56:21 +0100 5621265 http://www.medworm.com/index.php?rid=5621266&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F46t87v6215648124%2F Abstract  Spontaneous resolution of syringomyelia in adult patients with Chiari malformation is exceptionally rare, with only 10 cases having been reported. A 21-year-old man working as a carpenter presented with a 1-year history of paresthesias in his right arm. A magnetic resonance imaging scan disclosed a cervicothoracic syrinx associated with tight tonsillar impaction of the cisterna magna without herniation. The patient left the carpentry job and underwent close monitoring with serial clinical and neuroradiological controls. The patient’s symptoms gradually disappeared and magnetic resonance imaging studies revealed progressive shrinkage of the syrinx despite persistence of crowding of posterior fossa structures at the level of the foramen magnum. This case suggests ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5621266 Thu, 19 Jan 2012 06:56:20 +0100 5621266 http://www.medworm.com/index.php?rid=5621268&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb7v315h6025179u2%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10072-012-0950-zAuthors Hideyuki Matsumoto, Department of Neurology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, JapanRitsuko Hanajima, Department of Neurology, University of Tokyo, Tokyo, JapanYasuo Terao, Department of Neurology, University of Tokyo, Tokyo, JapanHideji Hashida, Department of Neurology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, JapanYoshikazu Ugawa, Department of Neurology, School of Medicine, Fukushima Medical University, Fukushima, Japan Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5621268 Thu, 19 Jan 2012 06:56:19 +0100 5621268 http://www.medworm.com/index.php?rid=5621267&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk672880x65p41766%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10072-012-0945-9Authors Giampiero Porzio, L’Aquila per la Vita, Home Care Unit, L’Aquila, ItalyFederica Aielli, L’Aquila per la Vita, Home Care Unit, L’Aquila, ItalyLucilla Verna, L’Aquila per la Vita, Home Care Unit, L’Aquila, ItalyFrancesco Martella, L’Aquila per la Vita, Home Care Unit, L’Aquila, ItalyCatia Capannolo, L’Aquila per la Vita, Home Care Unit, L’Aquila, ItalyAlejandra Palma, L’Aquila per la Vita, Home Care Unit, L’Aquila, ItalyPaolo Aloisi, L’Aquila per la Vita, Home Care Unit, L’Aquila, ItalyCorrado Ficorella, Medical Oncology Department, University of L’Aquila, L’Aquila, Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Sourc... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5621267 Thu, 19 Jan 2012 06:56:19 +0100 5621267 http://www.medworm.com/index.php?rid=5611115&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv674360p7472u427%2F The objective of this study was to determine the relationship between sleepiness and migraine in the intercritical period and to evaluate the time course of critical drowsiness during the attacks. One hundred patients fulfilling IHCD 2nd (2004) criteria for migraine without aura were compared to 100 healthy subjects. Habitual excessive daily sleepiness, evaluated by means of Epworth Sleepiness Scale, was not more frequent in patients with episodic migraine than in controls (12% migraineurs vs. 8% controls, NS). The analysis of critical sleepiness by means of Stanford Sleepiness Scale (SSS) revealed a beginning of sleepiness increase before the attack onset, starting 12 h before, a peak of SSS values at the migraine attack onset and then a gradual decrease to reach baseline value... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5611115 Tue, 17 Jan 2012 07:10:55 +0100 5611115 http://www.medworm.com/index.php?rid=5611116&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc056828818267112%2F We describe a 62-year-old female diagnosed with Alzheimer’s disease, who had been treated with donepezil for approximately 1 year. When she developed a low-grade fever and digestive complaints, her family physician interpreted these symptoms as side effects of the drug and ordered donepezil to be discontinued. Not only was there no improvement of the somatic symptoms after discontinuation of donepezil, but there was also a worsening of the dementia symptoms, culminating in delirium. When donepezil was re-prescribed, the delirium resolved and the patient’s mental state stabilized. The authors urge great caution in discontinuing treatment with acetylcholinesterase inhibitors such as donepezil. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-012-... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5611116 Tue, 17 Jan 2012 07:10:54 +0100 5611116 http://www.medworm.com/index.php?rid=5599360&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh840783w01263774%2F We report a case of trigeminal neuralgia caused by persistent trigeminal artery (PTA) associated with asymptomatic left temporal cavernoma. Our patient presented unstable blood hypertension and the pain of typical trigeminal neuralgia over the second and third divisions of the nerve in the right side of the face. The attacks were often precipitated during physical exertion. MRI and Angio-MRI revealed the persistent carotid basilar anastomosis and occasionally left parietal cavernoma. After drug treatment of blood hypertension, spontaneous recovery of neuralgia was observed and we planned surgical treatment of left temporal cavernoma. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s10072-012-0942-zAuthors Renata Conforti, Department of Neurological Sciences... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5599360 Fri, 13 Jan 2012 16:54:22 +0100 5599360 http://www.medworm.com/index.php?rid=5599359&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh0t65702x7477811%2F Abstract  Post-polio syndrome (PPS) is a clinical syndrome of new weakness, fatigue and musculoskeletal pain occurring in a variable proportion of polio survivors decades after acute disease. To date, several risk factors for PPS development have been reported, although the etiology of this disorder remains elusive. Using a case–control design, we aimed to assess risk indicators for PPS in a group of Italian polio survivors. Subjects with prior poliomyelitis attending the rehabilitation hospital of Malcesine, Italy, were the target population. Patients with PPS, diagnosed according to the European Federation of Neurological Societies criteria, served as cases, while patients not meeting diagnostic criteria for PPS were used as controls. All subjects were assessed through ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5599359 Fri, 13 Jan 2012 16:54:22 +0100 5599359 http://www.medworm.com/index.php?rid=5599361&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6848604nu564nv72%2F Abstract  Nocistatin and nociceptin/orphanin FQ (N/OFQ) are two neuropeptides which may have opposite effects in several biological functions but their neuro-anatomical sites of interaction are not fully clear. We investigated interaction between the effect of intracerebroventricular (i.c.v.) injection of nocistatin and N/OFQ, on c-Fos expression in the mouse thalamus, using c-Fos immunohistochemistry. We found that co-injection of nocistatin with N/OFQ significantly modulates c-Fos expression in the thalamus. The present study strongly suggests that “Nocistatin–Nociceptin” interaction system in the thalamus may be the promising neuromodulatory sites in the investigation of unlocking their possible therapeutic circuit in nociception, memory and anxiety. Content Ty... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5599361 Thu, 12 Jan 2012 16:48:13 +0100 5599361 http://www.medworm.com/index.php?rid=5599362&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fmq314pl79g661x32%2F Abstract  Episodic memory is frequently impaired in multiple sclerosis (MS) patients but the exact nature of the disorder is controversial. It was initially thought to be due to a retrieval deficit but some studies have demonstrated an encoding deficit, which could be linked to a slowing of information processing speed or to a deficit in elaboration of strategies. The main objective of this study is to assess the prevalence and the nature of verbal episodic memory (VEM) impairment in MS patients. We retrieved memory performances of 426 patients [314 F–112 M; mean age: 46.1 years; median Expanded Disability Status Scale (EDSS) score: 3.1] from a neuropsychological data base. VEM was assessed using the 16 words RL-RI 16 test. 66% MS patients present at least one recall... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5599362 Thu, 12 Jan 2012 16:48:12 +0100 5599362 http://www.medworm.com/index.php?rid=5584652&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F242w725472840g04%2F In conclusion, EIF3B promotes the proliferation of U87 cells and may play an important role in human glioblastoma development. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s10072-011-0894-8Authors Hong Liang, Department of Neurosurgery, Daping Hospital of the Third Military Medical University, 400042 Chongqing, ChinaXuehua Ding, Department of Neurosurgery, Changzheng Hospital, Shanghai, ChinaChun Zhou, Department of Neurosurgery, Daping Hospital of the Third Military Medical University, 400042 Chongqing, ChinaYihua Zhang, Department of Neurosurgery, Daping Hospital of the Third Military Medical University, 400042 Chongqing, ChinaMinhui Xu, Department of Neurosurgery, Daping Hospital of the Third Military Medical University, 400042 Chongqing, ChinaChengq... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5584652 Tue, 10 Jan 2012 16:57:06 +0100 5584652 http://www.medworm.com/index.php?rid=5584651&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa52k2925211l0hg6%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s10072-011-0929-1Authors Jae Hyoung Kim, Department of Radiology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaJeong-Min Hwang, Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166, Gumiro, Bundang-gu, Seongnam, Gyeonggi-do 463-707, Korea Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5584651 Tue, 10 Jan 2012 16:57:06 +0100 5584651 http://www.medworm.com/index.php?rid=5584650&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft4002jm1936mw213%2F We report a 71-year-old man with legionellosis, who presented with abducens nerve palsy, singultus, confusion, memory impairment, ataxia, and hyporeflexia. Legionella pneumonia was diagnosed on the basis of detection of Legionella pneumophila antigen in the urine. The cerebrospinal fluid was negative for the antigen and antibody, but an oligoclonal band was detected, and the IgG index was elevated. It was speculated that an undetermined immune-mediated mechanism had contributed to the development of the neurological manifestations. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-011-0927-3Authors Shingo Konno, Division of Neurology, Department of Internal Medicine, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro-ku, Tokyo, 153-8515 JapanHa... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5584650 Tue, 10 Jan 2012 16:57:06 +0100 5584650 http://www.medworm.com/index.php?rid=5584653&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fju444v7gg8167t3w%2F Abstract  Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis has been recently identified as a fulminant encephalopathy, presenting with a variety of symptoms including behavioral change, amnesia and seizures suggesting cortical gray matter involvement. A 42-year-old woman presented with acute-onset clinical and magnetic resonance imaging (MRI) findings indicating brainstem and diencephalon involvement. Her neuropsychological examination revealed mild frontal dysfunction with no memory impairment. Detailed diagnostic workup proved negative except for serum/cerebrospinal fluid (CSF) NMDAR-antibodies and increased activity in inguinal and pelvic lymph nodes on positron-emission tomography (PET) examination. The symptoms and MRI findings completely resolved following ster... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5584653 Mon, 09 Jan 2012 19:37:01 +0100 5584653 http://www.medworm.com/index.php?rid=5584655&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9l41821hu358g656%2F This study investigated the effects of physical exercise on motor deficits and the expression of glial fibrillary acidic protein (GFAP) in a model of Parkinson’s disease (PD). Rats were divided into four groups: sham sedentary (SS) and sham trained (ST); lesioned sedentary (LS) and lesioned trained (LT). 6-OHDA was infused unilaterally into the medial forebrain bundle. Behavioral tasks were applied to evaluate motor abilities. Tyrosine hydroxylase (TH—in substantia nigra) and GFAP (in striatum) immunoreactivities (ir) were semi-quantified using optical density. The animals submitted to treadmill training completed fewer pharmacological-induced rotations when compared with sedentary animals and they also showed ameliorated motor impairments. Interestingly, although no change in TH... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5584655 Mon, 09 Jan 2012 19:37:00 +0100 5584655 http://www.medworm.com/index.php?rid=5584654&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh1g47ju018809513%2F Abstract  Our previous studies have showed that ginsenoside (GS)-Rd, a mono-compound isolated from traditional Chinese herb panax ginseng, has the neuroprotective effects following ischemic stroke. However, the underlying mechanisms are still largely unknown. Our latest study showed that GS-Rd could block calcium influx in cultured cortical neurons after excitotoxic injury, indicating that GS-Rd may act on cation channels. To explore this possibility, in this study, we used a rat middle cerebral artery occlusion (MCAO) model to examine the effects of GS-Rd on the expression of non-selective cation channels, including transient receptor potential melastatin (TRPM) and acid sensing ion channels (ASIC), and cation channels, including N-methyl-d-aspartate (NMDA) receptors, which... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5584654 Mon, 09 Jan 2012 19:37:00 +0100 5584654 http://www.medworm.com/index.php?rid=5584656&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8g37hwt860544352%2F Abstract  Intracranial metastases from uterine leiomyosarcoma are very rare and have been found mainly in the brain (17 cases); on the other hand, metastases to the skull, dura and orbit are really exceptional. The authors report the case of a 57-year-old woman who presented with a 6-week history of right proptosis, left hemiparesis, intracranial hypertension and torpor 8 months after surgery for uterine leiomyosarcoma. CT scan showed a very large right frontal tumor with both intracranial and intraorbital extension. At operation the tumor was found to arise from the dura of the right anterior cranial fossa; complete removal of the intracranial tumor mass and partial removal of the intraorbital component were performed. However, early tumor regrowth was observed 45&nbs... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5584656 Mon, 09 Jan 2012 19:36:59 +0100 5584656 http://www.medworm.com/index.php?rid=5573033&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7247252286880u88%2F Abstract  Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease in which much burden is geared towards end-of-life care. Particularly in the earlier stages of ALS, many people have found both physiological and psychological boosts from various types of physical exercise for disused muscles. Proper exercise is important for preventing atrophy of muscles from disuse—a key for remaining mobile for as long as possible—and as long as it is possible to exercise comfortably and safely, for preserving cardiovascular fitness. However, the typical neuromuscular patient features a great physical inactivity and disuse weakness, and for that reason many controversial authors have contested exercise in these patients during years, especially in ALS ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5573033 Fri, 06 Jan 2012 16:47:40 +0100 5573033 http://www.medworm.com/index.php?rid=5573034&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F67831623651073xv%2F We report on a 44-year-old male who developed clinically definite ALS by the revised El Escorial criteria with onset weeks after mild electric injury. He presented with asymmetric upper limb amyotrophy and weakness beginning around the entry point of the current. Over 1 year he developed generalized wasting, weakness and fasciculations, including the bulbar and thoracic muscles, with prominent spasticity and pyramidal tract signs. Electrodiagnostic studies confirmed widespread denervation, very unstable neurogenic motor units in the bulbar, cervical, thoracic and lumbosacral segments with normal motor velocities and normal sensory parameters. This is a well-documented case of fast-progressive ALS that seems related to electric injury. Content Type Journal ArticleCategory Ca... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5573034 Fri, 06 Jan 2012 16:47:39 +0100 5573034 http://www.medworm.com/index.php?rid=5573035&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx0k2601q540x7266%2F Abstract  Here we describe a case of Neurofibromatosis type 1 (NF1) associated with an atypical histiocytic lesion and a new pathogenic mutation. The genetic analysis revealed an heterozygous mutation in the 5′ splice site of intron 32, 6,084 + 1G → T. Histopathological findings are compatible with juvenile xanthogranuloma. The new, not already described, splicing mutation, is possibly partly responsible of the association between NF1 and the histiocitic lesion. Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s10072-011-0897-5Authors Giovanni Bianco, Dipartimento di Neuroscienze, Sezione Neurologia e Neurofisiologia Clinica, Azienda Ospedaliera-Universitaria Senese, Policlinico Le Scotte, Viale Bracci, 53100 Siena, I... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5573035 Thu, 05 Jan 2012 17:06:27 +0100 5573035 http://www.medworm.com/index.php?rid=5573036&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F67171g3gq2503232%2F We report the case of a patient suffering from migraine with and without aura who had a complete remission of both during warfarin treatment for pulmonary embolism; the attacks reappeared promptly during two treatment withdrawals. We highlight warfarin as prophylactic drug in migraine prophylaxis and discuss about new, safer and more specific anticoagulants that could be used in migraine treatment. Their use could also clarify literature’s conflicting data about anticoagulants’ efficacy in migraine prophylaxis and clear if their efficacy in migraine treatment could be related aspecifically to anticoagulation’s effect or to a particular mechanism in the coagulation cascade. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-011-0926-4Authors F. Mag... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5573036 Thu, 05 Jan 2012 17:06:26 +0100 5573036 http://www.medworm.com/index.php?rid=5573037&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv476v856705572w8%2F Abstract  The co-occurrence of microcephaly and Legg–Calvè–Perthes disease (LCPD) in members of the same family has been previously recorded only in two Hungarian brothers. To study the clinical and radiological phenotype in a (second) family with LCPD and microcephaly, clinical, X-ray and MRI follow-up study of two Albanian siblings aged 8 and 11 years, were made. Both siblings had primary microcephaly, seizures and mild-to-moderate mental retardation. At head imaging the boy was found to have skull asymmetry, partial lack of frontal lobe development and partial agenesis of corpus callosum and the girl had a complex brain malformation consisting in thickening of the fronto-temporal cortex, colpocephaly, increased curvature of the Sylvian fissure, elevated tentori... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5573037 Thu, 05 Jan 2012 17:06:25 +0100 5573037 http://www.medworm.com/index.php?rid=5573039&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl207846641714817%2F We report a case of a 51-year-old man with multiple myeloma who presented with lumbar pain and left limb paresis. Cerebrospinal fluid, brain and spinal cord resonance imaging revealed a diffuse infiltration of the cauda equina without any cranial leptomeningeal enhancement. An infiltration limited to the cauda equina is extremely rare. Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s10072-011-0920-xAuthors Thiago Cardoso Vale, Neurology Division, University Hospital, Federal University of Minas Gerais (UFMG), Avenida Professor Alfredo Balena 110/Terceiro Andar, Ala Oeste (Serviço de Neurologia), Santa Efigênia, Belo Horizonte, MG CEP 30130100, BrazilGustavo Machado Teixeira, Bone Marrow Transplantation Unit, Haematology Division, University Hospita... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5573039 Wed, 04 Jan 2012 16:49:45 +0100 5573039 http://www.medworm.com/index.php?rid=5573038&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv0349rq716542835%2F Abstract  Cerebral ischemia is the main cause of cognitive impairment. Changes in dendritic morphology and spines have been shown to occur with synaptic plasticity and cognitive function. Bilateral occlusion of the common carotid arteries (2VO) in rats was an effective model of chronic cerebral ischemia. In this experiment, SD rats were divided into model group (2VO) and sham-operated group. At 2, 4, 8 and 16 weeks, rats were tested in Morris water maze to observe learning and memory abilities, and then the brain tissue was stained by Golgi method to investigate the morphology of dendrites of pyramidal neurons under light microscope. Dendritic length and arborization and spine density of pyramidal neurons in medial prefrontal cortex (mPFC) and hippocampal CA1 were anal... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5573038 Wed, 04 Jan 2012 16:49:45 +0100 5573038 http://www.medworm.com/index.php?rid=5573041&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjul016w58w20568k%2F Abstract  We know little about effective treatment for patients suffering from partial or complete Klüver-Bucy Syndrome (KBS) and other disruptive behaviors following a stroke. Reported cases have shown that certain medication, given alone or combined, can be partially effective. In this specific case study, we will try to demonstrate the effectiveness of a combination of carbamazepine, clonidine, quetiapine and methylphenidate in the alleviating of these symptoms. The wide range of symptoms found in KBS led us to use several kinds of psychotropic medication in spite of the inherent risks associated to polypharmacy. Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s10072-011-0911-yAuthors Luigi De Benedictis, Fernand-Seguin Research Center... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5573041 Wed, 04 Jan 2012 06:59:38 +0100 5573041 http://www.medworm.com/index.php?rid=5573040&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft1w56124m30067m5%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10072-011-0882-zAuthors Vivekananda Lahan, Department of Psychiatry and Sleep Clinic, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Doiwala, Dehradun, 248140 IndiaSohaib Ahmad, Department of Medicine, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Doiwala, Dehradun, 248140 IndiaRavi Gupta, Department of Psychiatry and Sleep Clinic, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Doiwala, Dehradun, 248140 India Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5573040 Wed, 04 Jan 2012 06:59:38 +0100 5573040 http://www.medworm.com/index.php?rid=5561989&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr342174426155135%2F Abstract  Although flexion cervical MRI has been recommended for the diagnosis of Hirayama disease (HD), no study focused on the MR features at different neck flexion angles. Moreover, no uniform flexion angle has been confirmed in clinical practice. The purpose of this study is to quantitatively investigate the MRI typical signs of HD patients in different neck flexion degree and gives a suggestion to the MR scanning. Cervical MRI in neutral and different flexion positions (cervical flexion angle 20°, 25°, 30°, 35°, and 40°) were performed in 45 HD patients. Three MRI features including anterior shifting of the posterior wall of the cervical dural canal (ASD), widening of cervical epidural space, and epidural flow voids (EFV) at each flexed position were summarized. T... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5561989 Mon, 02 Jan 2012 16:53:29 +0100 5561989 http://www.medworm.com/index.php?rid=5561990&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg8757r686161m584%2F Abstract  Highly adhesive glycoprotein von Willebrand factor (VWF) multimer induces platelet aggregation and leukocyte tethering or extravasation on the injured vascular wall, contributing to microvascular plugging and inflammation in brain ischemia–reperfusion. A disintegrin and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS13) cleaves the VWF multimer strand and reduces its prothrombotic and proinflammatory functions. Although ADAMTS13 deficiency is known to amplify post-ischemic cerebral hypoperfusion, there is no report available on the effect of ADAMTS13 on inflammation after brain ischemia. We investigated if ADAMTS13 deficiency intensifies the increase of extracellular HMGB1, a hallmark of post-stroke inflammation, and exacerbates brain injury after ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5561990 Mon, 02 Jan 2012 16:53:28 +0100 5561990 http://www.medworm.com/index.php?rid=5561991&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0274l79565184055%2F We report a case of a young man presenting with a cerebellar infarction probably secondary to a paradoxical brain-to-brain embolism, in which the only detectable embolic source was a cerebral vein thrombosis. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-011-0908-6Authors P. La Spina, Department of Neuroscience, Neurological Clinic, University of Messina, Via Consolare Valeria 3, 98124 Messina, ItalyR. S. Calabrò, IRCCS Centro Neurolesi “Bonino-Pulejo”, Messina, ItalyC. Casella, Department of Neuroscience, Neurological Clinic, University of Messina, Via Consolare Valeria 3, 98124 Messina, ItalyR. Savica, Department of Neuroscience, Neurological Clinic, University of Messina, Via Consolare Valeria 3, 98124 Messina, ItalyF. Granata, Department of Ne... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5561991 Sat, 31 Dec 2011 16:48:21 +0100 5561991 http://www.medworm.com/index.php?rid=5561992&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhn32181667730v22%2F We present a patient with neuromyelitis optica who exhibited longitudinally extensive transverse myelitis and aquaporin-4 IgG positivity. Patient did not have optic neuritis clinically, but we detected it with examination of visual evoked potentials (prolonged P100 wave latans), subclinically. We argue that neuromyelitis optica may also be considered in elderly patients with isolated involvement of the longitudinally extensive transverse myelitis, and visually evoked potential evaluation is important to determine of subclinic optic neuritis and anti-AQP-4 is also important to support to determination. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s10072-011-0917-5Authors Emine Rabia Koç, Department of Neurology, Fatih University School of Medicine, Fatih ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5561992 Fri, 30 Dec 2011 16:42:45 +0100 5561992 http://www.medworm.com/index.php?rid=5561994&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F806g167u6qn68234%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10072-011-0919-3Authors Yohei Asakawa, Stroke Division, Department of Neurology, Dokkyo Medical University, Shimotsuga, Tochigi, JapanHidehiro Takekawa, Stroke Division, Department of Neurology, Dokkyo Medical University, Shimotsuga, Tochigi, JapanKeisuke Suzuki, Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, JapanShigeru Toyoda, Department of Cardiovascular Medicine, Dokkyo Medical University, Shimotsuga, Tochigi, JapanTeruo Inoue, Department of Cardiovascular Medicine, Dokkyo Medical University, Shimotsuga, Tochigi, JapanKoichi Hirata, Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga, Tochigi 321-0293, Japan ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5561994 Fri, 30 Dec 2011 16:42:44 +0100 5561994 http://www.medworm.com/index.php?rid=5561993&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1723717451251t77%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10072-011-0923-7Authors Simone Gallerini, Department of Neuroscience, University of Pisa, Pisa, ItalyAlberto Chiti, Department of Neuroscience, University of Pisa, Pisa, ItalyGino Gialdini, Department of Neuroscience, University of Pisa, Pisa, ItalyNicola Giannini, Department of Neuroscience, University of Pisa, Pisa, ItalyGiovanni Orlandi, Department of Neuroscience, University of Pisa, Pisa, Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5561993 Fri, 30 Dec 2011 16:42:44 +0100 5561993 http://www.medworm.com/index.php?rid=5561995&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp3x2612332853354%2F We report five MS patients with femoral head necrosis who had relapsing remitting MS and received different doses of methyl prednisolone. Our young cases consist of three females and two males. The duration of disease varied between 1 and 3 years. The least interval between the last pulse of prednisolone and diagnosis of avascular necrosis was 6 months. Two of them received one pulse of 5 g of methyl prednisolone. All five patients had delayed diagnosis because the signs and symptoms were attributed to MS, which indicate the necessity of further focusing attention to early evaluations. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s10072-011-0914-8Authors M. A. Sahraian, Department of Neurology, Sina MS Research Center, Sina Hospital, Tehran... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5561995 Fri, 30 Dec 2011 16:42:43 +0100 5561995 http://www.medworm.com/index.php?rid=5561996&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F72ut88235x712456%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10072-011-0890-zAuthors Bengt Edvardsson, Department of Neurology, Faculty of Medicine, Lund University Hospital, 221 85 Lund, Sweden Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5561996 Fri, 30 Dec 2011 07:07:53 +0100 5561996 http://www.medworm.com/index.php?rid=5553287&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F97370312q3828g73%2F Abstract  Ca2+-calmodulin (CaM) dependent protein kinase II (CaMKII) is an important intracellular signal transduction pathway. CaMKII is rich in the primary sensory neurons and specifically presents in the small- and medium-sized neurons. It remains unclear about the modulation on the excitability of primary sensory neurons by Ca2+–CaM–CaMKII pathway. By current clamp recording, we found that the excitability of capsaicin-sensitive small and medium trigeminal ganglion (TG) neurons was significantly reduced by a CaM specific antagonist (W-7) and a CaMKII antagonist (KN-93). The inhibition is represented as the reduction of numbers of action potential (AP), decrease of the amplitude of AP, increase of threshold, and prolongation of duration of AP. Consistently, by voltage... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5553287 Wed, 28 Dec 2011 16:49:36 +0100 5553287 http://www.medworm.com/index.php?rid=5553288&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9l58424gr4062tn3%2F In this study, we used the multiplex ligation-dependent probe amplification (MLPA) analysis for screening 93 patients (52 familial and 41 isolated cases). As a result, we identified 11 different deletions and 1 duplication in the SPAST gene and a single exon deletion in the ATL1 gene. These results indicate that micro-rearrangements in the SPAST gene are a fairly frequent cause of hereditary spastic paraplaegia and that MLPA is a useful and efficient technique to detect a considerable proportion of the mutations in the most common forms of hereditary spastic paraplaegias. Content Type Journal ArticleCategory Brief CommunicationPages 1-4DOI 10.1007/s10072-011-0899-3Authors Anna Sulek, Department of Genetics, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957 Warsaw, Pola... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5553288 Tue, 27 Dec 2011 17:01:55 +0100 5553288 http://www.medworm.com/index.php?rid=5553289&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq4464g6605478651%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10072-011-0910-zAuthors Dong Hoon Shin, Department of Neurology, Ajou University Medical Center, Ajou University School of Medicine, San 5, Wonchondong, Suwon, Youngtonggu 443-721, South KoreaSun Wook Lee, Department of Neurology, Ajou University Medical Center, Ajou University School of Medicine, San 5, Wonchondong, Suwon, Youngtonggu 443-721, South KoreaYoon Hue Hong, Department of Neurology, Ajou University Medical Center, Ajou University School of Medicine, San 5, Wonchondong, Suwon, Youngtonggu 443-721, South KoreaJi Man Hong, Department of Neurology, Ajou University Medical Center, Ajou University School of Medicine, San 5, Wonchondong, Suwon, Youngtonggu 443-721, South KoreaJin Soo Lee, Department of ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5553289 Tue, 27 Dec 2011 17:01:53 +0100 5553289 http://www.medworm.com/index.php?rid=5553292&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7u6g71151h183p48%2F Abstract  Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disease of upper and lower motor neurons. Sensory involvement is thought not to be a feature of ALS. We reviewed 17 cases of sural nerve biopsies performed in a large cohort of ALS patients referred to our centre over a 23-year period. More than two-third of biopsies revealed a variable degree of axonal loss. In one case, pathological findings suggested the concomitant presence of an inherited neuropathy, subsequently confirmed by genetic evaluation. In another case, pathological and neurographic data were similar to those of an inflammatory demyelinating neuropathy, but the clinical course corroborated the diagnosis of ALS. Our data confirm that sensory nerve involvement may be found in ALS patient... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5553292 Tue, 27 Dec 2011 17:01:51 +0100 5553292 http://www.medworm.com/index.php?rid=5553291&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff06mwp2711517m06%2F Abstract  Reelin is a glycoprotein that acts as a stop signal for neuronal migration during brain ontogenesis. It plays an important role in the remodeling of the hippocampal formation and in stabilizing cortical architecture. We studied immunohistochemically 30 cases of focal cortical dysplasia (FCD) type IIIa to verify whether Reelin could represent the pathogenetic link between HS and cortical dyslamination in the setting of FCD type IIIa. Our results suggest that a subset of FCD type IIIa (namely abnormal cortical layering associated with MTS and GCD type 2) exists in which loss of Reelin appears to be the common pathogenetic basis. On the contrary in the other cases the presence of a common pathogenetic link remains to be demonstrated. Content Type Journal ArticleC... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5553291 Tue, 27 Dec 2011 17:01:51 +0100 5553291 http://www.medworm.com/index.php?rid=5553290&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp5331810u6965201%2F Abstract  Several movement disorders may occur during nocturnal rest disrupting sleep. A part of these complaints is characterized by relatively simple, non-purposeful and usually stereotyped movements. The last version of the International Classification of Sleep Disorders includes these clinical conditions (i.e. restless legs syndrome, periodic limb movement disorder, sleep-related leg cramps, sleep-related bruxism and sleep-related rhythmic movement disorder) under the category entitled sleep-related movement disorders. Moreover, apparently physiological movements (e.g. alternating leg muscle activation and excessive hypnic fragmentary myoclonus) can show a high frequency and severity impairing sleep quality. Clinical and, in specific cases, neurophysiological assessment... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5553290 Tue, 27 Dec 2011 17:01:51 +0100 5553290 http://www.medworm.com/index.php?rid=5545617&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft158t22812121008%2F This study was undertaken to evaluate the role of ACE and αADDUCIN polymorphisms in patients with recurrent and nonrecurrent hypertensive intracerebral hemorrhage (ICH). A total of 101 nonrecurrent and 33 recurrent hypertensive ICH patients underwent an ACE (rs4646994) and αADDUCIN (rs4961) gene polymorphism study. The risk factors, clinical findings, CT scan abnormalities and functional outcome of recurrent and nonrecurrent ICH were compared. ACE (rs4646994) and αADDUCIN (rs4961) gene polymorphisms were also compared in the two groups and with 198 controls. The patients with recurrent ICH were older compared to those with nonrecurrent ICH and the other stroke risk factors were found in the two groups. Ganglionic–ganglionic pattern of recurrence was the commonest (75.6%) and all... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5545617 Fri, 23 Dec 2011 16:51:26 +0100 5545617 http://www.medworm.com/index.php?rid=5545618&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2j6vm8313w453032%2F Abstract  The aim of this study was to investigate the results of both clinical testing and standardised nerve conduction studies performed on patients with Carpal tunnel syndrome (CTS) complaints, who had been referred to the neurologist by their general practitioners. Analysis of the data of neurological examination and electrodiagnostic tests (EDX) were performed on patients that had been referred by general practitioners. A total of 232 patients with clinically defined CTS, who had been referred by general practitioners, were seen by a neurologist and subsequently underwent electrodiagnostic testing. The diagnosis of CTS made by general practitioners was clinically confirmed by the neurologist in 187 of 232 (81%) patients. In these 187 patients, EDX confirmed CTS clinica... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5545618 Fri, 23 Dec 2011 16:51:24 +0100 5545618 http://www.medworm.com/index.php?rid=5545619&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhg8k831k2614653j%2F In this study, we investigated the effectiveness of three bedside cognitive tests in consecutive patients with PD without postural instability. Of the 119 patients, 39 experienced falls during the follow-up period. Of the bedside cognitive assessment methods examined, only the Montreal Cognitive Assessment (MoCA) score was significantly lower in the group of fallers than in the group of non-fallers. This result suggests that the MoCA is effective as a bedside test for evaluating the risk of falls. Content Type Journal ArticleCategory Brief CommunicationPages 1-4DOI 10.1007/s10072-011-0906-8Authors Joong-Seok Kim, Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South KoreaWooyoung Jang, Department of Neurology, Hanyang University College of ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5545619 Fri, 23 Dec 2011 16:51:23 +0100 5545619 http://www.medworm.com/index.php?rid=5545621&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F884352082779r449%2F We present here a 25-year-old woman with genetically confirmed (p.R276L mutation in the GFAP gene) juvenile-onset AxD. Episodic vomiting appeared at age nine, causing anorexia and insufficient growth. Brain MRI at age 11 showed a small nodular lesion with contrast enhancement in the left dorsal portion of the cervicomedullary junction. Her episodic vomiting improved spontaneously at age 13, and she became neurologically asymptomatic. The enhancement of the lesion disappeared simultaneously, although the plaque remained. Longitudinal MRI observations, however, revealed insidiously progressive cervicomedullary atrophy without a signal change. This case broadens our knowledge of AxD: (1) molecular analysis of the GFAP gene is warranted in patients with MRI evidence of tumor-like lesions ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5545621 Fri, 23 Dec 2011 16:51:22 +0100 5545621 http://www.medworm.com/index.php?rid=5545620&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fqvl4337245646275%2F We report a case of cerebral hemorrhage in a patient with hypertension who was first diagnosed as hypertensive cerebral hemorrhage. However, treponema pallidum particle agglutination and rapid plasma regain tests of cerebrospinal fluid revealed the existence of neurosyphilis. Interestingly, digital subtraction angiography (DSA) showed severe stenosis in both middle cerebral arteries and right anterior cerebral artery. The case reminded us to pay attention to syphilitic vasculitis in patients with cryptogenic stroke. DSA sometimes may play a critical role in differential diagnosis of neurosyphilis. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s10072-011-0887-7Authors Xia Zhang, The Department of Neurology, The Second Affiliated Hospital of Soochow Univers... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5545620 Fri, 23 Dec 2011 16:51:22 +0100 5545620 http://www.medworm.com/index.php?rid=5545622&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3453563080636134%2F Abstract  Mitochondrial disorders are caused by impairment of the respiratory chain. Psychiatric features often represent part of their clinical spectrum. However, the real incidence of psychiatric disorders in these diseases is unknown. The aim of this study was to evaluate psychiatric involvement in a group of patients with mitochondrial disorders and without already diagnosed mental illness. Twenty-four patients with mitochondrial disorder and without already diagnosed mental diseases have been studied by means of the mini-international neuropsychiatric interview (MINI) and the newcastle mitochondrial diseases adult scale (NMDAS). In patients with mitochondrial disease, psychiatric conditions were far more common than in general Italian population (about 60 vs. 20–25%)... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5545622 Thu, 22 Dec 2011 16:38:07 +0100 5545622 http://www.medworm.com/index.php?rid=5545623&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhv1u6g5p6333444l%2F We report on a 20-year-old boy with an 8-year history of progressive difficulty in walking, running and climbing stairs. Muscle biopsy showed a lipid myopathy and the acylcarnitine profile analysis was suggestive of MADD. Nevertheless, no evidence of molecular defects in the ETFA, ETFB and ETFDH exons or intron–exon boundaries was found. Treatment with riboflavin for 1 year resulted in a clear improvement in motor functions. Our report shows that some cases of MADD are not linked to ETFA, ETFB and ETFDH exon or intron–exon boundary changes. They could be due to quite rare promoter or deep intronic mutations or, most likely, to some unknown genetic defect. We therefore suggest to extend in these cases molecular studies to cDNA analysis and indicate the need of extensive pedigr... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5545623 Wed, 21 Dec 2011 20:08:03 +0100 5545623 http://www.medworm.com/index.php?rid=5539250&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl112277m51q33q1n%2F We present a patient with nodular infarction who had positional vertigo with nystagmus as a sole manifestation. Video-oculography showed apogeotropic positional horizontal nystagmus during head turning while supine, which was consistent with apogeotropic BPPV involving the horizontal canal. MRI disclosed acute infarct in the nodulus. Nodulus infarction should be considered in a patient with positional nystagmus, especially when the presenting symptoms and signs are consistent with BPPV involving the horizontal canal. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-011-0884-xAuthors Hyun-Ah Kim, Department of Neurology, Keimyung University School of Medicine, 194 Dongsan dong, Daegu, 700-712 South KoreaHyon-Ah Yi, Department of Neurology, Keimyung Univ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5539250 Tue, 20 Dec 2011 16:45:56 +0100 5539250 http://www.medworm.com/index.php?rid=5539251&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F42238rr42t734x42%2F Abstract  A 58-year-old man developed muscle weakness and had more than 1,000 CTG repeats in the myotonin protein kinase gene. He was diagnosed as having myotonic dystrophy. At the time of diagnosis, a large tumor was detected in his abdominal cavity on CT scan examination. He died from pneumonia 6 years later. At autopsy, the abdominal tumor was diagnosed as a lipoma. Several types of tumor have been reported to be associated with myotonic dystrophy type 1; however, this is the first detailed clinical case demonstrating the possible relationship between myotonic dystrophy and lipoma. Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10072-011-0896-6Authors Yohsuke Yagi, Department of Neurology, Musashino Red Cross Hospital, Kyonancho ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5539251 Tue, 20 Dec 2011 16:45:54 +0100 5539251 http://www.medworm.com/index.php?rid=5539252&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb4wk756430222421%2F Abstract   Saitohin (STH) is an intronless gene nested within the human tau gene, which contains a single nucleotide polymorphism (A/G), suggested to be involved in the physiopathology and clinical course of several neurodegenerative and neuropsychiatric diseases. Recently, an association between this polymorphism and frontal hypoperfusion and clinical prognosis in frontotemporal dementia was reported. The present study sought to evaluate the possible role of the STH polymorphism as a concurring factor of cognitive decline in schizophrenia, a disease sharing both early psychotic manifestations, a core deficit of executive functions and hypofrontality with frontotemporal lobe dementia. 220 clinically stabilized patients with schizophrenia were assessed with the Wisconsin Car... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5539252 Tue, 20 Dec 2011 16:45:52 +0100 5539252 http://www.medworm.com/index.php?rid=5539253&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft46543070312m2u2%2F Abstract  Paragangliomas are rare neuroendocrine tumors of neural crest origin. They are mostly benign, however; malignant tumors with aggressive behavior and distant metastasis can also occur. Intracranial involvement is extremely rare and has been sporadically reported in the literature. Here we report a case who presented with progressive neurologic deficits due to multiple intracranial lesions found to be metastasis from an occult retroperitoneal malignant paraganglioma. Content Type Journal ArticleCategory Case ReportPages 1-2DOI 10.1007/s10072-011-0879-7Authors Peihao Cai, Department of Neurosurgery, Shanghai Shuguang Hospital, Affiliated Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaAli Mahta, Department of Neurosciences, Moores ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5539253 Tue, 20 Dec 2011 16:45:51 +0100 5539253 http://www.medworm.com/index.php?rid=5526951&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh662357p280h56q7%2F Abstract  Accumulating evidence indicates that the intraneuronal accumulation of beta-amyloid peptide (Aβ) is earlier than the formation of extraneuronal amyloid plaque but the mechanism of the accumulation remains unclear. p75NTR is a receptor for Aβ and interacts with Aβ in vitro and in vivo but whether p75NTR mediates Aβ internalization and intraneuronal accumulation is not known. In this study, we aim to determine if p75NTR mediates Aβ internalization, which might provide new insights into Aβ metabolism and toxicity. FRET analysis in PC12 cells showed that internalized Aβ was close to p75NTR. Aβ1–42 could be internalized in PC12 cells in a concentration-dependent manner but the antibody to the p75NTR extracellular domain did not prevent its internalization. A�... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5526951 Mon, 19 Dec 2011 16:51:54 +0100 5526951 http://www.medworm.com/index.php?rid=5526950&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr6u6j350w643m92m%2F The objective of the present study was to explore a potential association between the estrogen receptor β (ERβ) gene polymorphisms and vascular dementia (VaD) in women. The relationship of two polymorphisms (rs944050 and rs4986938) and their associated haplotypes in the ERβ gene with VaD were examined in 121 Chinese Han women (>50 years of age) including 61 with VaD and 60 healthy age-matched controls. The potential associations were evaluated using unconditional logistic regression. The variant allele G of rs944050 in the ERβ gene increased the risk of VaD (odds ratio = 2.02, 95% confidence interval = 1.08–3.77). In haplotype analyses, the ERβ haplotype containing the polymorphism rs944050 variant allele and the polymorphism rs4986938 wild-type all... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5526950 Mon, 19 Dec 2011 16:51:54 +0100 5526950 http://www.medworm.com/index.php?rid=5526952&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq354157318494637%2F We describe the case of a young woman suffering from migraine. After some years, the headache started to be accompanied by internal ophthalmoplegia. Mydriasis was unilateral and after a few months became bilateral. The ophthalmoplegic migraine is a rare type of headache and it is characterized by paresis of one or more of the third, fourth or sixth cranial nerves. Migraine attacks associated with mydriasis (internal ophthalmoplegia) are extremely rare. Triptan therapy resolved mydriasis, but not the headache. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-011-0883-yAuthors Marco Simonetto, Division of Neurology, Department of Specialty Medicine, Azienda ULSS 15 “Alta Padovana”, Cittadella Hospital, Padova, ItalyLuca Zanet, Division of Neurology, ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5526952 Mon, 19 Dec 2011 16:51:53 +0100 5526952 http://www.medworm.com/index.php?rid=5526954&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp082042201375214%2F We report a patient presenting with orgasmic headache associated with large supratentorial arachnoid cyst. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-011-0786-yAuthors Sa-Yoon Kang, Department of Neurology, College of Medicine, Jeju National University, 1 Ara 1-dong, Jeju, 690-756 Jeju-do, KoreaJay Chol Choi, Department of Neurology, College of Medicine, Jeju National University, 1 Ara 1-dong, Jeju, 690-756 Jeju-do, KoreaJi-Hoon Kang, Department of Neurology, College of Medicine, Jeju National University, 1 Ara 1-dong, Jeju, 690-756 Jeju-do, KoreaJung Seok Lee, Department of Neurology, College of Medicine, Jeju National University, 1 Ara 1-dong, Jeju, 690-756 Jeju-do, Korea Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-187... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5526954 Mon, 19 Dec 2011 16:51:52 +0100 5526954 http://www.medworm.com/index.php?rid=5526953&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy8060277218473vm%2F Abstract  Pain in Amyotrophic Lateral Sclerosis is often underestimated and untreated by clinicians and few studies have investigated its specific features and impact. Pain experience was investigated with the Italian Questionnaire of Pain, together with the McGill Quality of Life Questionnaire for quality of life (QoL), at a baseline and at a 4-month follow-up. About half of ALS patients reported pain, described as nagging, sore, annoying, boring and exhausting, with periodic but enduring episodes. Pain was related with QoL and its intensity was able to predict QoL worsening. Obtained results indicate the importance of clinical investigation of pain in ALS patients and of the intervention with anti-pain treatment whenever necessary. Content Type Journal ArticleCategory... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5526953 Mon, 19 Dec 2011 16:51:52 +0100 5526953 http://www.medworm.com/index.php?rid=5516341&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F779u01w5807550m5%2F Abstract  According to the reserve hypothesis, a high educational/occupational attainment can modulate Alzheimer’s disease (AD) clinical expression. The impact of the Apolipoprotein E (ApoE) ε4 allele on the reserve mechanism in AD has not been assessed. Aim of this European multicenter study was to evaluate the metabolic correlates of reserve and ApoE genotype in early probable AD. 51 AD subjects, 27 ε4 carriers, and 24 noncarriers, underwent FDG-PET brain imaging. We used the general linear model as implemented in SPM2 to test for the linear correlation of a reserve index, accounting for both educational and occupational level, with brain glucose metabolism, controlling for demographic variables (age and gender) and for cognitive performance. We found an inverse correl... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5516341 Thu, 15 Dec 2011 16:49:48 +0100 5516341 http://www.medworm.com/index.php?rid=5516342&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx1824744568n212n%2F Abstract  Oxidative stress leads to complex biochemical alterations, and has been implicated in the progressive loss of learning and memory. Supplementing and boosting the endogenous antioxidant defense system could impede the progression of various types of neurodegeneration. In the present study, we have investigated the neuroprotective efficacy of a low-dose combination of certain promising and powerful natural antioxidants in an experimental model of cognitive impairment. Combined pretreatment with the extract of Nardosatchys jatamansi (N), crocetin (C) and selenium (Se) as sodium selenite (N, 200 mg/kg + C, 25 μg/kg + Se, 0.05 mg/kg body weight) for 15 days led to improved behavioral outcomes in streptozotocin (STZ)-induced ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5516342 Wed, 14 Dec 2011 16:42:03 +0100 5516342 http://www.medworm.com/index.php?rid=5516344&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp62310307l548th7%2F In conclusion, GUO treatment did not prevent the cognitive impairment observed in 2VO animals, but our data suggest that GUO could be neuroprotective against hippocampal damage induced by 2VO. Content Type Journal ArticleCategory Original ArticlePages 1-13DOI 10.1007/s10072-011-0872-1Authors Marcelo Ganzella, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos, 2600, anexo, Santana, Porto Alegre, RS 90035-003, BrazilEnderson Dias Alves de Oliveira, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos, 2600, anexo, Santana, Porto Alegre, RS 90035-003, BrazilDaniel Diniz Comassetto, Departamento de Bioquímica, Instituto de Ci�... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5516344 Tue, 13 Dec 2011 17:04:39 +0100 5516344 http://www.medworm.com/index.php?rid=5516343&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F8734284m0k798v74%2F Abstract  Genome-wide association studies (GWAS) identified multiple single-nucleotide polymorphisms (SNPs) that are associated with the pathogenesis of Alzheimer’s disease (AD). As replication in independent studies remains the only way to validate proposed GWAS signals, we detect SNPs reported in the GWAS, in order to explore their association with sporadic AD (SAD) in the Chinese population. We analyzed genotype and allele distributions of 19 SNPs reported in GWAS in 191 SAD patients and 180 healthy controls. We found that higher frequencies of rs10868366 G and rs7019241 C carriers were observed in SAD patients compared with controls (rs10868366 G: P = 0.026, odds ratio (OR) = 1.4, 95% confidence intervals (CI) 1.0–1.9; rs7019241 C: P = 0... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5516343 Tue, 13 Dec 2011 17:04:39 +0100 5516343 http://www.medworm.com/index.php?rid=5516345&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff31253tn87248423%2F Abstract  A 45-year-old male presented with subacute onset of a right-sided hemiparesis, right homonymous hemianopsia, and slurred speech. The brain imaging revealed two separate intraparenchymal enhancing lesions. The cerebrospinal fluid rapid plasma reagin and venereal disease research laboratory test were positive and consistent with syphilitic gumma, and the patient responded dramatically to penicillin G. Despite, currently low incidence of syphilis; CNS gummas should be in the differential of mass lesions as they are eminently treatable. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-011-0878-8Authors Jing-cheng Li, Department of Neurology, Daping Hospital, Third Military Medical University, Chongqing, 400042 ChinaAli Mahta, Department... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5516345 Tue, 13 Dec 2011 17:04:38 +0100 5516345 http://www.medworm.com/index.php?rid=5495933&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa45148810r5716p0%2F In conclusion, TCS is an effective and useful tool to detect PD and to distinguish PD from ET in Chinese patients. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s10072-011-0876-xAuthors Wei-Feng Luo, Department of Ultrasound, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu 215004, ChinaYing-Chun Zhang, Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaYu-Jing Sheng, Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaJun-Chu Fang, Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaChun-Feng Liu, Department of Ultrasound, The Second Affiliated Hospital of Soochow Uni... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5495933 Sat, 10 Dec 2011 16:55:44 +0100 5495933 http://www.medworm.com/index.php?rid=5495934&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh627tg5x4h163281%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s10072-011-0874-zAuthors Matteo Pugnaghi, Clinica Neurologica, Dipartimento di Neuroscienze, Università di Modena e Reggio Emilia, Nuovo Ospedale C. Sant’Agostino e Estense, Baggiovara, Modena, ItalyMariangela Molinari, Clinica Neurologica, Dipartimento di Neuroscienze, Università di Modena e Reggio Emilia, Nuovo Ospedale C. Sant’Agostino e Estense, Baggiovara, Modena, ItalyPatrizia Panzetti, Clinica Neurologica, Dipartimento di Neuroscienze, Università di Modena e Reggio Emilia, Nuovo Ospedale C. Sant’Agostino e Estense, Baggiovara, Modena, ItalyPaolo F. Nichelli, Clinica Neurologica, Dipartimento di Neuroscienze, Università di Modena e Reggio Emilia, Nuovo Ospedale C. Sant’Agostino e Estense, Ba... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5495934 Sat, 10 Dec 2011 16:55:43 +0100 5495934 http://www.medworm.com/index.php?rid=5495935&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx280265wh4628323%2F We describe a patient who displayed a progressive parkinsonian phenotype fulfilling the criteria for PSP over a period of a year. The parkinsonism was the initial manifestation of HIV infection and was eliminated by highly active antiretroviral therapy. This case report indicates that one should consider HIV infection as a cause of PSP-like parkinsonism. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-011-0875-yAuthors Wooyoung Jang, Department of Neurology, College of Medicine, Hanyang University, 17 Haengdangdong, Seongdong-gu, Seoul, 133-792 KoreaJoong-Seok Kim, Department of Neurology, The Catholic University College of Medicine, Seoul, KoreaJin Young Ahn, Department of Neurology, Seoul Medical Center, Seoul, KoreaHee-Tae Kim, Department of Neurolog... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5495935 Thu, 08 Dec 2011 18:22:41 +0100 5495935 http://www.medworm.com/index.php?rid=5495936&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw178m06486647283%2F Abstract  Ipsilateral hemiparesis and spontaneous nystagmus have rarely been reported after a cerebral lesion. A 35-year-old man with agenesis of the corpus callosum developed ipsilateral hemiparesis and spontaneous horizontal nystagmus after an infarct in the right middle cerebral artery territory. Magnetic resonance imaging revealed the presence of an acute infarct in the right middle and inferior frontal gyrus, supramarginal gyrus, insular gyrus, internal capsule, head of caudate nucleus, putamen, and globus pallidus. Transcranial stimulation of the hand area of the cerebral motor cortex produced motor-evoked potentials in the abductor pollicis brevis muscle exclusively on the ipsilateral side. No motor-evoked potentials were evoked in the abductor pollicis brevis muscle... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5495936 Thu, 08 Dec 2011 18:22:40 +0100 5495936 http://www.medworm.com/index.php?rid=5488490&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx1512614l77133p5%2F Abstract  Autologous haematopoietic stem cell transplantation (AHSCT) is a promising treatment for multiple sclerosis (MS) patients who have not adequately responded to conventional therapies. We retrospectively evaluated the safety and long-term clinical outcome of AHSCT in MS patients in China. Twenty-five patients with various types of MS were treated with AHSCT. Peripheral blood stem cells were derived by leukapheresis after mobilized with granulocyte colony-stimulating factor. Then CD34+ cell selection of the graft was performed and anti-thymocyte globulin was given for T-cell depletion, with the conditioning regimen BEAM adopted and early and late toxicities recorded. Long-term responses were evaluated by the expanded disability status scale (EDSS), progression-free s... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5488490 Wed, 07 Dec 2011 10:52:19 +0100 5488490 http://www.medworm.com/index.php?rid=5488491&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk2287q1523lqh860%2F Abstract  Previous papers show different patterns of seasonal distribution of multiple sclerosis attacks. This paper compares long-time modifications. Salerno MS registry (Southern Italy), was reviewed, including 189 patients, age onset 12–51 years (mean = 29.88, SD = 8.4), disease duration mean = 6.94 years (1–29), attacks mean = 4.5 (2–25, SD = 3.41). Data were stratified by decades. Number of events/month was analyzed by odds ratios and forecast modeling (ARIMA); means by ANOVA and post hoc tests, and correlations by multiple regression. We found 869 relapses: J = 72, F = 48, M = 122, A = 75, M = 68, Jn = 59, Jl = 81, A = 74, S&n... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5488491 Mon, 05 Dec 2011 17:43:35 +0100 5488491 http://www.medworm.com/index.php?rid=5477995&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb41137j5n3007760%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s10072-011-0870-3Authors Dokyung Lee, Departments of Neurology, College of Medicine, Kyung Hee University Hospital, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-702 KoreaSung Hyuk Heo, Departments of Neurology, College of Medicine, Kyung Hee University Hospital, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-702 KoreaEui-Jong Kim, Department of Radiology, College of Medicine, Kyung Hee University, Seoul, KoreaDae-Il Chang, Departments of Neurology, College of Medicine, Kyung Hee University Hospital, Kyung Hee University, #1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-702 Korea Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Scienc... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5477995 Thu, 01 Dec 2011 19:20:49 +0100 5477995 http://www.medworm.com/index.php?rid=5477996&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F402512q543363j57%2F Abstract  New knowledge from scientific research on vegetative state (VS) and its consequences in clinical practice are reviewed. The ambiguity of the concept of consciousness and the difficult issue of its moral significance are then examined. The Authors stress the need for longitudinal prognostic studies, the promotion of an expert widespread use of standardized behavioural scales, and recommend that the ethical debate about VS rely upon the widest consensus of the scientific community. Content Type Journal ArticleCategory News and ViewsPages 1-6DOI 10.1007/s10072-011-0867-yAuthors Daniela Tarquini, Neurologa, UOC Neurologia, PTP Nuovo Regina Margherita, Rome, ItalyMaria Congedo, Neurologa, ASS n. 4 “Medio Friuli”, Ambulatorio di Neurologia, Udine, Distretto di U... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5477996 Wed, 30 Nov 2011 18:43:02 +0100 5477996 http://www.medworm.com/index.php?rid=5470266&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcj800j3472l10871%2F We present a patient with epilepsy who developed psychotic symptoms under the treatment of valproic acid (VPA) and lamotrigine (LTG) combination. The mechanism underlying the association between LTG, seizure control and development of psychosis are discussed in the light of the literature. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-011-0869-9Authors A. B. Turan, Department of Neurology, Uludag University Medical Faculty, 16059 Gorukle/Bursa, TurkeyM. Seferoglu, Department of Neurology, Uludag University Medical Faculty, 16059 Gorukle/Bursa, TurkeyO. Taskapilioglu, Department of Neurology, Uludag University Medical Faculty, 16059 Gorukle/Bursa, TurkeyI. Bora, Department of Neurology, Uludag University Medical Faculty, 16059 Gorukle/Bursa, Turkey ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5470266 Wed, 30 Nov 2011 18:43:02 +0100 5470266 http://www.medworm.com/index.php?rid=5470267&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk8605x2l23hr6030%2F Abstract  The study of neurodegenerative diseases, such as frontotemporal lobar degeneration (FTLD), in isolated populations represents a privileged point of view for identifying new causative genes and pathogenetic mechanisms. Vallecamonica is a valley located in the Brescia province (Northern Italy), which experienced isolation until the end of World War II. The aims of the present work were (1) to estimate the prevalence of FTLD in Vallecamonica, (2) to determine the monogenic FTLD forms, and (3) to identify FTLD cases with no evidence of known pathogenetic mutations and the related clinical features. Patients meeting current clinical criteria for FTLD were considered. Mutation analysis for microtubule associated protein tau (MAPT) and progranulin (PGRN) genes was perform... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5470267 Wed, 30 Nov 2011 04:55:47 +0100 5470267 http://www.medworm.com/index.php?rid=5459540&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fcq27h0352332478t%2F This study was aimed to compare the patterns of hospital use by immigrants incoming to the Acute Care Department of Neurology in Brescia, Italy, with those of the resident Italian people. The study was based on the hospital discharge data. Discharges of immigrants were compared to those of a random selection of Italian patients matched by age and sex. The length of the study period was of 2.5 years. A similar pattern of hospital use by age was observed between foreigners and Italian patients; however, average length of hospitalization was significantly longer in immigrant population. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s10072-011-0868-xAuthors Fabrizio Rinaldi, Neurological Department, University of Brescia, Brescia, ItalyPaolo Liberini... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5459540 Mon, 28 Nov 2011 16:59:13 +0100 5459540 http://www.medworm.com/index.php?rid=5459539&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5q2572213040515t%2F Content Type Journal ArticleCategory Quiz CasesPages 1-3DOI 10.1007/s10072-011-0858-zAuthors Marco Tironi, Department of Neurology, San Gerardo Hospital, University of Milano-Bicocca, Monza, ItalyLucio Tremolizzo, Department of Neurology, San Gerardo Hospital, University of Milano-Bicocca, Monza, ItalyGiovanni Stefanoni, Department of Neurology, San Gerardo Hospital, University of Milano-Bicocca, Monza, ItalyMonica Airoldi, Department of Infectious Disease, San Gerardo Hospital, University of Milano-Bicocca, Monza, ItalyEleonora Motta, Department of Infectious Disease, San Gerardo Hospital, University of Milano-Bicocca, Monza, ItalyMirko Patassini, Neuroradiology Service, San Gerardo Hospital, University of Milano-Bicocca, Monza, ItalyFrancesco Canonico, Neuroradiology Service, San Ger... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5459539 Mon, 28 Nov 2011 16:59:13 +0100 5459539 http://www.medworm.com/index.php?rid=5459542&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3330m277p6p6p541%2F In conclusion, the inexorable progressive growing nature of this tumor leads us to advocate an aggressive attitude among neurosurgeons and radiotherapists, with a precocious surgical approach when the suspicion rises. Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.1007/s10072-011-0860-5Authors A. Santoro, Department of Neurological Sciences-Neurosurgery, University of Rome “Sapienza”, Piazza San Giovanni Bosco, 86, 00175 Rome, ItalyA. D’Elia, Department of Neurological Sciences-Neurosurgery, University of Rome “Sapienza”, Piazza San Giovanni Bosco, 86, 00175 Rome, ItalyB. Fazzolari, Department of Neurological Sciences-Neurosurgery, University of Rome “Sapienza”, Piazza San Giovanni Bosco, 86, 00175 Rome, ItalyF. Santoro, Department of Neurological Sci... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5459542 Mon, 28 Nov 2011 16:59:12 +0100 5459542 http://www.medworm.com/index.php?rid=5459541&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbg05818u54878576%2F This study emphasizes that neuroimaging studies may be useful to differentiate gnathostomiasis and angiostrongyliasis particularly in patients with indistinct clinical presentations. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s10072-011-0864-1Authors Jaturat Kanpittaya, Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002 ThailandKittisak Sawanyawisuth, Research and Diagnostic Center for Emerging Infectious Disease, Khon Kaen University, Khon Kaen, ThailandPewpan M. Intapan, Research and Diagnostic Center for Emerging Infectious Disease, Khon Kaen University, Khon Kaen, ThailandPiyarat Khotsri, Department of Parasitology, Faculty of Medicine, Khon Kaen University, 123 Mitraparp Road, Khon Kaen, 40002 ThailandVerajit Ch... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5459541 Mon, 28 Nov 2011 16:59:12 +0100 5459541 http://www.medworm.com/index.php?rid=5459544&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F26111535h816536j%2F We report on a 66-year-old woman with a posterior circulation stroke that occurred after bronchial artery embolization (BAE) due to post-tuberculous bronchiectasis. Stroke is a rare complication of BAE and is usually thought to be caused by inadvertent embolization via a bronchial artery–pulmonary vein shunt. However, the possibility of thromboembolic stroke should be considered, because of the patient’s possible underlying anatomical variations or atherothrombosis. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s10072-011-0855-2Authors Jong-Ho Park, Stroke Center, Department of Neurology, Myongji Hospital, Kwandong University College of Medicine, 697-24 Hwajeong-dong, Deokyang-gu, Goyang, Gyeonggi-do 412-270, KoreaDong-Sun Kim, Department of Neurology, ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5459544 Mon, 28 Nov 2011 16:59:11 +0100 5459544 http://www.medworm.com/index.php?rid=5459543&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj08616511008hw8k%2F Abstract  The early differentiation between Alzheimer’s disease (AD) and frontal variant of frontotemporal dementia (fvFTD) is frequently difficult, albeit critical for the adequate management of patients and their caregivers. In order to assess the accuracy of CSF levels of beta-amyloid 1–42 (Aβ), tau (τ) and Thr 181-phosphorilated tau (Pτ) in the early differentiation of AD from fvFTD, we designed a prospective study in which patients have been followed up for at least 2 years. Seventy-two patients with AD and 42 patients with fvFTD showed significantly different CSF levels of Pτ (increased in AD, p = 0.0001), Aβ (reduced in AD, p = 0.03), and ratios of Pτ to Aβ (p = 0.003). ROC analyses showed that the ratio Pτ/Αβ is able to... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5459543 Mon, 28 Nov 2011 16:59:11 +0100 5459543 http://www.medworm.com/index.php?rid=5459546&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4812k237043m0571%2F Abstract  To devise a multivariate parametric model for short-term prediction of disability using the Expanded Disability Status Scale (EDSS) and multimodal sensory EP (mEP). A total of 221 multiple sclerosis (MS) patients who underwent repeated mEP and EDSS assessments at variable time intervals over a 20-year period were retrospectively analyzed. Published criteria were used to compute a cumulative score (mEPS) of abnormalities for each of 908 individual tests. Data of a statistically balanced sample of 58 patients were fed to a parametrical regression analysis using time-lagged EDSS and mEPS along with other clinical variables to estimate future EDSS scores at 1 year. Whole sample cross-sectional mEPS were moderately correlated with EDSS, whereas longitudinal mEPS w... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5459546 Sat, 26 Nov 2011 16:46:56 +0100 5459546 http://www.medworm.com/index.php?rid=5459545&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl570n83l2h403824%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s10072-011-0863-2Authors Ettore Salsano, SOSD Clinica delle Neuropatie Degenerative Centrali e Periferiche, Fondazione IRCCS, Istituto Neurologico C. Besta, Milan, ItalyOrsola Gambini, DMCO, Università degli Studi di Milano, AO San Paolo, Milan, ItalyAnna Rita Giovagnoli, SOSD Neuropsicologia Clinica, Fondazione IRCCS, Istituto Neurologico C. Besta, Milan, ItalyLaura Farina, UO Neuroradiologia, Fondazione IRCCS, Istituto Neurologico C. Besta, Milan, ItalyGraziella Uziel, SOSD Malattie Genetiche Metaboliche e Degenerative, Fondazione IRCCS, Istituto Neurologico C. Besta, via Celoria 11, 20133 Milan, ItalyDavide Pareyson, SOSD Clinica delle Neuropatie Degenerative Centrali e Periferiche, Fondazione IRCCS, Isti... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5459545 Sat, 26 Nov 2011 16:46:56 +0100 5459545 http://www.medworm.com/index.php?rid=5459547&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk513g40106110766%2F In conclusion, the presence of high TOS and OSI levels together with low levels of TAS in diabetic patients with or without neuropathy may support a role of oxidative stress in the pathogenesis of diabetes mellitus. In addition, increased serum prolidase activity in DN may be interpreted as evidence of increased collagen turnover. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s10072-011-0857-0Authors Ertugrul Uzar, Department of Neurology, Faculty of Medicine, Dicle University School of Medicine, 21280 Diyarbakir, TurkeyYusuf Tamam, Department of Neurology, Faculty of Medicine, Dicle University School of Medicine, 21280 Diyarbakir, TurkeyOsman Evliyaoglu, Department of Biochemistry, Faculty of Medicine, Dicle University School of Medicine, Diyarbakir, T... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5459547 Sat, 26 Nov 2011 16:46:55 +0100 5459547 http://www.medworm.com/index.php?rid=5459548&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft78852v77112n6nr%2F Abstract  Neuromyelitis optica (NMO) is an antibody-mediated disease with the target antigen being the water channel aquaporin-4 (AQP4). More than 90% of NMO patients have relapse. Optimal treatments to prevent recurrence have not been established. Previous reports suggest that interferon beta (IFNB) has not been effective in NMO. However, we present a case of NMO with positive anti-myelin oligodendrocyte glycoprotein (MOG)27–38 IgG and anti-AQP4 IgG treated with IFNB-1a successfully. The effect of IFNB on NMO and the role of anti-MOG antibodies in NMO deserve further study. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-011-0849-0Authors Yan Xu, Department of Neurology, Peking Union Medical College Hospital, 1 Shuaifuyuan, Dongcheng Dist... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5459548 Sat, 26 Nov 2011 16:46:53 +0100 5459548 http://www.medworm.com/index.php?rid=5450266&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhr47073706285u37%2F We describe five female RR-MS patients with incomplete response to HDC-AHSCT. Natalizumab was then administered with abolition of both MRI and clinical activity. No severe adverse events, in particular opportunistic infections such as Progressive Multifocal Leukoencephalopathy (PML), were observed. Our results suggest that the use of natalizumab in aggressive RR-MS after HDC-AHSCT could be effective and safe. The very long-term risk of adverse events due to sequential aggressive immunosuppression has to be established. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s10072-011-0848-1Authors Marco Capobianco, Department of Neurology 2, Regional Multiple Sclerosis Centre, AOU San Luigi Gonzaga, Regione Gonzole 10, 10043 Orbassano, ItalyY. Motuzova, Depart... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5450266 Thu, 24 Nov 2011 17:43:40 +0100 5450266 http://www.medworm.com/index.php?rid=5450267&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5257072v28783852%2F We report two cases of solitary brain metastases, showing different histological types, which have been excised with microsurgical technique. Neuroendocrine differentiation does not seem to be connected to clinical behavior, indeed a poor prognosis depends on poorly differentiated histological types. In our cases, brain metastases were a late event and they have been successfully excised in microsurgery, thanks to their solitary and resectable nature, and a well-controlled primary disease. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s10072-011-0861-4Authors A. Marongiu, Department of Neurosurgery, INM Neuromed IRCCS, Via Atinense 18, Pozzilli, IS, ItalyM. Salvati, Department of Neurosurgery, INM Neuromed IRCCS, Via Atinense 18, Pozzilli, IS, ItalyA. D’... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5450267 Wed, 23 Nov 2011 17:37:17 +0100 5450267 http://www.medworm.com/index.php?rid=5450268&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc590474182455030%2F We report a case of bilateral brachial neuritis with clinical and electrophysiological pure sensory involvement diagnosed using brachial plexus MRI. Although electrophysiological examination is thought to be the best diagnostic technique in the diagnosis of brachial neuritis, its findings sometimes indicate a distal lesion, while the involvement of the whole brachial plexus can be seen in MRI. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s10072-011-0856-1Authors Sibel Gazioglu, Department of Neurology, Karadeniz Technical University Medical Faculty, 61080 Trabzon, TurkeyCavit Boz, Department of Neurology, Karadeniz Technical University Medical Faculty, 61080 Trabzon, TurkeyAhmet Sarı, Department of Radiology, Karadeniz Technical University Medical Faculty... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5450268 Wed, 23 Nov 2011 17:37:15 +0100 5450268 http://www.medworm.com/index.php?rid=5423714&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk34x82207g962k63%2F Abstract  A male child suffering from generalized tonic clonic epilepsy, on treatment with valproate, developed fulminant hepatic failure, hyperammonemia and encephalopathy due to drug toxicity. The most extraordinary feature was his MRI (FLAIR image) of brain which showed unilateral hyperintensities in right putamen and caudate nucleus. The patient recovered on withdrawal of valproate with mild residual left sided athetotic movements during remission. Repeat investigation confirmed an improved MRI imaging and normalised blood ammonia levels. The case report is unique because of unilateral involvement of basal ganglia due to valproate-induced encephalopathy. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s10072-011-0852-5Authors Swarnali Joardar,... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5423714 Tue, 15 Nov 2011 16:58:40 +0100 5423714 http://www.medworm.com/index.php?rid=5410422&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F32004117t2w327l7%2F Abstract  Central pontine myelinolysis and extrapontine myelinolysis are rare demyelinating diseases of the central nervous system. These diseases are related frequently to rapid correction of hyponatremia. They have also been described in association with other underlying conditions such as alcoholism and malnutrition. In the present study, we report a case of central pontine and extrapontine myelinolysis with acute hepatic dysfunction. The patient had no apparent evidence of hyponatremia and no history of alcohol abuse. On admission, the patient was lethargic; dysphagia, dysarthria, and quadriplegia were noted. Laboratory examination showed significantly increased transaminase without hyponatremia. Magnetic resonance imaging revealed abnormal signal intensities in the pon... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5410422 Sat, 12 Nov 2011 16:53:41 +0100 5410422 http://www.medworm.com/index.php?rid=5410423&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh0p24j43188289t3%2F Abstract  A 67-year-old man complained of a transient blurring of vision in his right visual field lasting 30 min followed by headache. Two weeks later, the visual disturbance changed its pattern; it was described as the occurrence of brown round-shaped images in the right visual field spinning and turning for few seconds. This evolution from visual aura to visual seizures, with video-EEG correlation, supports the hypothesis of modification in threshold of cortical hyperexcitability from migraine to epilepsy. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s10072-011-0851-6Authors Filippo Dainese, Neurological Division, Epilepsy Centre, Campo SS Giovanni and Paolo Hospital, 30120 Venice, ItalyFederico Mainardi, Neurological Division, Headache C... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5410423 Fri, 11 Nov 2011 16:44:25 +0100 5410423 http://www.medworm.com/index.php?rid=5410424&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5571w20326181gvt%2F In conclusion, the data provide the evidence of an active involvement of zinc in neuronal damage. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s10072-011-0847-2Authors Lin Zhu, Department of Neurosurgery, School of Medicine, Jinling Hospital, Nanjing University, 305 East Zhongshan Road, 210002 Nanjing, Jiangsu Province, People’s Republic of ChinaYong Tang, Department of Neurosurgery, School of Medicine, Jinling Hospital, Nanjing University, 305 East Zhongshan Road, 210002 Nanjing, Jiangsu Province, People’s Republic of ChinaHan-dong Wang, Department of Neurosurgery, School of Medicine, Jinling Hospital, Nanjing University, 305 East Zhongshan Road, 210002 Nanjing, Jiangsu Province, People’s Republic of ChinaZhi-yuan Zhang, Department of Neurosurger... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5410424 Thu, 10 Nov 2011 16:52:08 +0100 5410424 http://www.medworm.com/index.php?rid=5410425&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F40h1m508312514j9%2F This study presents procedures and normative data for a rapid, comprehensive seven-test battery aimed at assessing colour perception, colour naming and object colour knowledge. The norms, obtained from 96 healthy Italian participants, allow normality/pathology judgements on the basis of one-sided tolerance limits, after adjusting the score of each test for the demographic variables of the proband subjects. We also report, as an example, use of the battery in a stroke patient; this patient was chosen because her lesion affected the left temporal–occipital cortex, an area sometimes associated with a deficit of colour processing. The patient resulted normal on colour perception and colour name retrieval, but defective on object colour knowledge probed using the stimulus name. For the ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5410425 Thu, 10 Nov 2011 16:52:06 +0100 5410425 http://www.medworm.com/index.php?rid=5410426&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk2768766565375n8%2F Abstract  The present study was carried out to elucidate the effectiveness of curcumin in ameliorating the expression of superoxide dismutase (SOD) in cerebral cortex and cerebellum of rat brain under 6-propyl-2-thiouracil (PTU)-induced hypothyroidism. Induction of hypothyroidism in adult rats by PTU resulted in augmentation of lipid peroxidation (LPx), an index of oxidative stress in cerebellum but not in cerebral cortex. Curcumin-supplementation to PTU-treated (hypothyroid) rats showed significant reduction in the level of LPx in both the regions of brain. The decreased translated products (SOD1 and SOD2) and the unchanged activity of SOD in cerebral cortex of PTU-treated rats were increased on supplementation of curcumin to the hypothyroid rats. Declined translated produ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5410426 Thu, 10 Nov 2011 16:52:05 +0100 5410426 http://www.medworm.com/index.php?rid=5410427&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm6m864111860nj05%2F In conclusion, we found a substantial concordance between PD staging, prevalence of nonmotor symptoms and patient-reported HRQoL and disability measures. In our opinion, the SF-36 and the WHO-DAS II can be used for profiling patients. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s10072-011-0846-3Authors Alberto Raggi, Neurology, Public Health and Disability Unit–Scientific Directorate, Neurological Institute C. Besta, IRCCS Foundation, Via Celoria 11, 20133 Milan, ItalyMatilde Leonardi, Neurology, Public Health and Disability Unit–Scientific Directorate, Neurological Institute C. Besta, IRCCS Foundation, Via Celoria 11, 20133 Milan, ItalyVenusia Covelli, Neurology, Public Health and Disability Unit–Scientific Directorate, Neurological Institute C... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5410427 Wed, 09 Nov 2011 17:46:20 +0100 5410427 http://www.medworm.com/index.php?rid=5410428&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5741281055461156%2F We report a case of cervical dystonia that was alleviated through the use of a visual-sensory trick. Our findings suggest that visual stimulation might be an effective sensory trick in cervical dystonia by compensating for a defective sensory system, or because visual pathways might be also affected by sensory interactions in cervical dystonia. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-011-0831-xAuthors Chan-Nyoung Lee, Department of Neurology, Korea University College of Medicine, Ansan, Republic of KoreaMi-Yeon Eun, Department of Neurology, Korea University College of Medicine, Ansan, Republic of KoreaDo-Young Kwon, Department of Neurology, Korea University College of Medicine, Ansan, Republic of KoreaMoon Ho Park, Department of Neurology, Korea... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5410428 Wed, 09 Nov 2011 17:46:17 +0100 5410428 http://www.medworm.com/index.php?rid=5410429&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw7411254j5w07385%2F Abstract  Although persistently raised serum creatine kinase (sCK), or hyperCKemia, is considered the biological hallmark of neuromuscular diseases, pauci- or asymptomatic- or isolated-hyperCKemia can often be found. Single-fiber electromyography (SFEMG) is an electrophysiological technique of great value in the assessment of neuromuscular, neuropathic and myopathic disorders. We hypothesize that SFEMG fiber density (FD) evaluation is able to detect subclinical electrophysiological abnormalities indicating a myopathic process in subjects with hyperCKemia. Nineteen subjects with hyperCKemia without evident clinical signs of muscle involvement and 15 healthy controls were studied. Electrophysiological investigations including nerve conduction studies (NCS), quantitative EMG (... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5410429 Wed, 09 Nov 2011 07:02:54 +0100 5410429 http://www.medworm.com/index.php?rid=5410431&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F54879u58413162kj%2F Abstract  Test sequences in a test battery for Parkinson’s disease patients, consisting of self-assessments and motor tests, were carried out repeatedly in a telemedicine setting, during week-long test periods and results were summarized in an ‘overall score’. 35 patients in stable and fluctuating conditions (15 age- and gender-matched pairs) used the test battery for 1 week, and were then assessed with UPDRS and PDQ-39. This procedure was repeated 1 week later, without treatment changes. Reliability was assessed by intraclass correlation coefficients and Cronbach’s alpha. Convergent validity was assessed by Spearman rank correlations and known-groups’ validity, by the Mann–Whitney test. According to anonymous usability questionnaires, the patients cou... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5410431 Wed, 09 Nov 2011 07:02:53 +0100 5410431 http://www.medworm.com/index.php?rid=5410430&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd7m125477m825274%2F The objective of this study was to investigate the relationship between neurologic signs and cognitive dysfunction in subcortical ischemic vascular dementia (SIVD). 121 patients with SIVD were recruited from multiple nationwide hospitals. The patients’ neurologic signs were evaluated using the Focal Neurologic Sign Score (FNSS). The FNSS scores did not correlate with the composite neuropsychology scores and Korean Mini-Mental State Examination scores. The FNSS scores correlated with the letter fluency and Rey–Osterrieth Complex Figure (ROCF) copy scores. Using a multivariate regression analysis controlled for age, sex, and educational level, the FNSS scores had a significant relationship with the letter fluency test scores (R 2 = 0.08, β = −2.28, p =&n... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5410430 Wed, 09 Nov 2011 07:02:53 +0100 5410430 http://www.medworm.com/index.php?rid=5410432&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F45686355361qp476%2F In conclusion, the administration of alpha-tocopherol enhances the reparative effects against SCI and it is more effective than ascorbic acid. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s10072-011-0829-4Authors Asirvatham Alwin Robert, Research Center, Sultan Bin Abdulaziz Humanitarian City, P.O. Box 64399, Riyadh, 11536 Saudi ArabiaMarwan Zamzami, Medical Affairs, Sultan Bin Abdulaziz Humanitarian City, Riyadh, Saudi ArabiaAsirvatham Edwin Sam, Voluntary Health Services, Chennai, IndiaMaher Al Jadid, Rehabilitation Medicine Division, Department of Neurosciences, Riyadh Military Hospital, Riyadh, Saudi ArabiaSultan Al Mubarak, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia Journal Neurological Science... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5410432 Tue, 08 Nov 2011 16:50:57 +0100 5410432 http://www.medworm.com/index.php?rid=5410433&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F077m6h742p06w22x%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s10072-011-0850-7Authors Angelo Labate, Institute of Neurology, University Magna Graecia, Catanzaro, ItalyMiriam Sturniolo, Institute of Neurological Sciences, National Research Council, Piano Lago, Mangone, Cosenza, ItalyFranco Pucci, Institute of Neurology, University Magna Graecia, Catanzaro, ItalyAldo Quattrone, Institute of Neurology, University Magna Graecia, Catanzaro, ItalyAntonio Gambardella, Institute of Neurological Sciences, National Research Council, Piano Lago, Mangone, Cosenza, Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5410433 Mon, 07 Nov 2011 17:14:18 +0100 5410433 http://www.medworm.com/index.php?rid=5389889&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb3p02w34k8m155rk%2F We present two Parkinson’s disease (PD) patients, who experienced heatstroke. Both patients manifested central nervous system dysfunction with elevated core temperature. Despite adequate lowering of the body temperature, multiorgan-dysfunction syndrome including encephalopathy, rhabdomyolysis, acute renal failure, acute respiratory failure, and disseminated intravascular coagulopathy was noted in one patient, leading to permanent neurologic damage. Because the ensuing multiorgan dysfunction could determine the functional prognosis in heatstroke patients, it is important to provide information about the prevention of heatstroke to patients, who are isolated or are severely disabled in the advanced stages of PD. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389889 Sat, 05 Nov 2011 17:10:11 +0100 5389889 http://www.medworm.com/index.php?rid=5389888&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk627884874985730%2F We report the clinical case of an adult man presented with an acute proximal hyposthenia, severe hyperckemia, clinical and laboratoristic evidence of acute tick borne virus infection. This virus has a favourite tropism for the anterior horn cells of the cervical spine segment. Polio-like syndrome, usually affecting the upper limbs, is the clinical phenotype of an infection of the cervical motoneurons. Usually myelitis is associated to severe encephalitis and a complete diagnosis may be difficult in comatose patients. Rarely, an isolated polio-like syndrome may be the sole neurological complication of tick-borne encephalitis. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s10072-011-0834-7Authors Sandro Zambito Marsala, Department of Neurology, Ospedale San... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389888 Sat, 05 Nov 2011 17:10:11 +0100 5389888 http://www.medworm.com/index.php?rid=5389890&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa4n243597801n485%2F We present the case report of 63-year-old patient with history of orthostatic hypotension, parkinsonism, progressive adynamia, and stridor. The patient was admitted to the hospital for diagnosis of orthostatic hypotension. A diagnosis of possible MSA was made. Because of patient’s complaints, an X-ray of the hip joint was taken. It revealed femoral neck fracture. Endoprosthesis insertion under general anesthesia was performed. Two days later the patient presented progressive adynamy and respiratory insufficiency. Endotracheal intubation and respiratory support were required followed by extubation and one more intubation. After second extubation, stridor and acute respiratory insufficiency occurred. Urgent tracheostomy was performed. After 13 days in ICU, the patient was disch... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389890 Sat, 05 Nov 2011 17:10:10 +0100 5389890 http://www.medworm.com/index.php?rid=5389891&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh85m332rv714h810%2F Abstract  A possible definition of clinical, educational and organizing aspects of emergency neurology in Italy is reported in this position paper of Emergency Neurology Intersociety Group, created in 2008 among the two neurological Societies in Italy: Società Italiana di Neurologia and Società di Neuroscienze Ospedaliere. The aim of this Group has been the evaluation of the role of neurologist in the emergency setting of Italian hospitals, as well as of the description of different scenarios in which a ward dedicated to a semi-intensive care of neurological emergencies could have a role in the actual organization of academic or general hospitals in our Country. The actual great relevance of neurologist activity in the inpatients treatment, in fact, is actually misleaded ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389891 Sat, 05 Nov 2011 17:10:09 +0100 5389891 http://www.medworm.com/index.php?rid=5389892&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp75j3rj147332r31%2F Abstract  A panel of Italian neurologists of the Italian Society for the study of Dementias (SINDEM) discussed the recently proposed new lexicon for Alzheimer disease (AD) and the related diagnostic criteria for the different phases of the disease (Preclinical AD, prodromal AD and Alzheimer’s dementia) (Dubois et al. in Lancet Neurol 6:734–746, 2007; in Lancet Neurol 9:1118–1127, 2010). The aim of this discussion was to reach a consensus, among the Italian neurologists involved in the study and care of persons with dementia, in particular in reference to the potential use of the proposed diagnostic criteria in clinical practice. After having critically revised the scientific evidence related to the new lexicon and to the new proposed diagnostic criteria, the panel conc... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389892 Fri, 04 Nov 2011 16:49:56 +0100 5389892 http://www.medworm.com/index.php?rid=5389893&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx4n6u130304h5677%2F Abstract  We observed, during a 25-year period, 15 patients from 6 families with autoimmune myasthenia gravis (all Chinese Han from Guangdong Province) referred to our department. Their mean onset age was 13.4 years (range 2–25 years) with 10 patients with juvenile onset. The female:male ratio was 3:2. Acetylcholine receptors antibody titers were increased in 11 patients (range 1.62–19.8 nmol/L). Thymectomy was performed in six patients, who received corticosteroids /immune inhibitor plus pyridostigmine treatments after surgery. The other patients were placed on therapy with azathioprine, cyclophosphamide, corticosteroids and acetylcholinesterase inhibitors. All patients responded well to immunosuppressants, and psychiatric symptoms were observed only in ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389893 Fri, 04 Nov 2011 16:49:54 +0100 5389893 http://www.medworm.com/index.php?rid=5389895&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6lhg276420603mtl%2F We reported a rare case of clinically severe, novel influenza A-associated encephalitis. Novel influenza A should be considered in the differential diagnosis in patients with seizures and mental status changes, especially during an influenza outbreak. Content Type Journal ArticleCategory Case ReportPages 1-3DOI 10.1007/s10072-011-0839-2Authors Faruk Incecik, Department of Pediatric Neurology, Cukurova University Medical Faculty, Toros mah. 40 sok. Omer Bayram Havuz apt., kat: 11, no: 11, Adana, TurkeyM. Ozlem Hergüner, Department of Pediatric Neurology, Cukurova University Medical Faculty, Toros mah. 40 sok. Omer Bayram Havuz apt., kat: 11, no: 11, Adana, TurkeySakir Altunbasak, Department of Pediatric Neurology, Cukurova University Medical Faculty, Toros mah. 40 sok. Omer Bayram... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389895 Fri, 04 Nov 2011 16:49:53 +0100 5389895 http://www.medworm.com/index.php?rid=5389894&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn81m7k8586123437%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10072-011-0843-6Authors Ivan Adamec, Department of Neurology, Refferal Center for Demyelinating Diseases of the Central Nervous System, University Hospital Center Zagreb, Kišpatićeva 12, HR-10000 Zagreb, CroatiaMario Habek, Department of Neurology, Refferal Center for Demyelinating Diseases of the Central Nervous System, University Hospital Center Zagreb, Kišpatićeva 12, HR-10000 Zagreb, Croatia Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389894 Fri, 04 Nov 2011 16:49:53 +0100 5389894 http://www.medworm.com/index.php?rid=5389896&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F434lj408mg662203%2F Abstract  Sleep disturbances are common in patients with Parkinson’s disease (PD). We aimed to evaluate prevalence and severity of nighttime sleep disturbances in Italian PD patients and to validate the Italian version of the Parkinson’s disease sleep scale. A total of 221 PD patients and 57 healthy controls participated in a cross-sectional study with retest. PDSS, Epworth Sleepiness Scale (ESS), Hamilton Depression Rating Scale, Unified Parkinson’s Disease Rating Scale (UPDRS), and Hoehn and Yahr staging were applied. PDSS total and individual items scores from patients were significantly lower than those in controls. Internal consistency of PDSS scale was satisfactory and intraclass correlation coefficient for test–retest reliability was 0.96 for total PDSS score... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389896 Wed, 02 Nov 2011 16:58:12 +0100 5389896 http://www.medworm.com/index.php?rid=5389898&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3376812j71q21124%2F Abstract  Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for ischemic cerebrovascular diseases, and results in worse prognosis and higher mortality. We aimed to investigate the effects of early treatment of OSAS on the prognosis of ischemic stroke. We prospectively evaluated patients with acute supratentorial ischemic stroke and OSAS on admission (acute stage), at second week (subacute stage) and at second month (chronic stage); 11 (73.3%) out of 15 patients put on the non-invasive mechanical ventilation treatment within 48 h of stroke constituted the treatment group, and 13 patients constituted the control group. Patients with OSAS treatment showed significantly better prognosis and better functioning in activities of daily living in both subacu... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389898 Wed, 02 Nov 2011 16:58:11 +0100 5389898 http://www.medworm.com/index.php?rid=5389897&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb865760403q4q365%2F Abstract  Using data from the PRIAMO study, we investigated non-motor symptoms (NMS) versus frontal lobe dysfunction in patients with idiopathic Parkinson disease (PD); 808 patients with PD and 118 with atypical parkinsonisms (AP) were consecutively enrolled at 55 Centers in Italy. Twelve categories of NMS were investigated. Cognitive impairment was defined as a Mini-Mental Status Evaluation score ≤23.8 and frontal lobe dysfunction as a Frontal Assessment Battery (FAB) score ≤13.48. Multivariable logistic regression was used to identify predictor of frontal lobe dysfunction in 524 PD patients, and a generalized linear model was used for each of the six FAB items. Not only the total FAB scores but also the single FAB items were lower in AP versus PD (p ≤ 0.00... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389897 Wed, 02 Nov 2011 16:58:11 +0100 5389897 http://www.medworm.com/index.php?rid=5389899&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa38up91lj574641n%2F Abstract  It is known that apoptosis may play a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). Moreover, caspase-9 is implicated in the apoptosis pathway. The aim of the study was to investigate caspase-9 levels in serum of patients with ALS. The study involved 30 patients with ALS and 30 patients from the control group. The serum caspase-9 levels were measured using the enzyme-linked immunosorbent method. The study showed that caspase-9 levels are significantly increased in serum of the patients with ALS comparing to the control group (p < 0.05). There was a significant correlation of serum caspase-9 levels with severity of clinical state of ALS patients and duration of the disease (p < 0.05). The results indicate that caspase-... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389899 Wed, 02 Nov 2011 16:58:10 +0100 5389899 http://www.medworm.com/index.php?rid=5389901&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw12477kt48054750%2F Abstract  Although being a physiologically important excitatory neurotransmitter, glutamate plays a pivotal role in various neurological disorders including ischemic neurological diseases. Its level is increased during cerebral ischemia with excessive neurological stimulation causing the glutamate-induced neuronal toxicity, excitotoxicity, and this is considered the triggering spark in the ischemic neuronal damage. The glutamatergic stimulation will lead to rise in the intracellular sodium and calcium, and the elevated intracellular calcium will lead to mitochondrial dysfunction, activation of proteases, accumulation of reactive oxygen species and release of nitric oxide. Interruption of the cascades of glutamate-induced cell death during ischemia may provide a way to preve... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389901 Tue, 01 Nov 2011 16:52:07 +0100 5389901 http://www.medworm.com/index.php?rid=5389900&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe066810184734u73%2F Abstract  Headache is the most frequent neurological chief complaint in the emergency room (ER). During diagnostic workup, accurate history taking still is the mainstay for identification of patients with a serious underlying disorder. However, in patients with an immigrant background, language problems and cultural influences on pain perception and pain-associated behavior can pose serious challenges for physicians. Here, we have evaluated the epidemiological characteristics of the chief complaint headache in ER patients with a probable immigrant background. We performed a retrospective study on 4,132 consecutive neurological ER patients. Identification of patients with probable immigrant background was done by a name based algorithm. Epidemiological characteristics of ER ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389900 Tue, 01 Nov 2011 16:52:07 +0100 5389900 http://www.medworm.com/index.php?rid=5389902&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm2010mn755510100%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-1DOI 10.1007/s10072-011-0736-8Authors Daniele Torchia, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1295 NW 14th Street, South Bldg, Suite K, Miami, FL 33125, USALawrence A. Schachner, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1295 NW 14th Street, South Bldg, Suite K, Miami, FL 33125, USA Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389902 Tue, 01 Nov 2011 16:52:06 +0100 5389902 http://www.medworm.com/index.php?rid=5389903&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F5809w88wx54w4186%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-3DOI 10.1007/s10072-011-0832-9Authors Elena Pretegiani, Department of Neurological, Neurosurgical and Behavioural Sciences, University of Siena, Viale Bracci, 53100 Siena, ItalyFrancesca Rosini, Department of Neurological, Neurosurgical and Behavioural Sciences, University of Siena, Viale Bracci, 53100 Siena, ItalyDonatella Donati, Department of Neurological, Neurosurgical and Behavioural Sciences, University of Siena, Viale Bracci, 53100 Siena, ItalyAlessandra Rufa, Department of Neurological, Neurosurgical and Behavioural Sciences, University of Siena, Viale Bracci, 53100 Siena, ItalyDonatella Moschettini, Department of Molecular Biology, University of Siena, Siena, ItalyAlfonso Cerase, UOC NINT,–Department of Neurosc... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5389903 Tue, 01 Nov 2011 16:52:05 +0100 5389903 http://www.medworm.com/index.php?rid=5365407&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F491j3l4312015625%2F Abstract  In healthy subjects, comfortable walking minimizes the energy cost (E c) of locomotion. In Parkinson’s disease (PD) patients walking is slower than in healthy subjects: this may increase E c. Our aims were to analyze gait and E c in PD patients during walking, particularly at self-selected speed, and the possible pathological, mechanical, and cardiorespiratory limitations. Fourteen mild-to-moderate PD and 14 control subjects were enrolled. Subjects underwent 5-min walking tests at two speeds: self-selected and as-fast-as-possible speeds. Cardiopulmonary and gait parameters (heart rate, ventilation, gas exchanges, step count) were recorded. Velocity was reduced in PD compared to control subjects at both speeds (P < 0.05), and PD patients had shorter ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5365407 Mon, 31 Oct 2011 16:47:50 +0100 5365407 http://www.medworm.com/index.php?rid=5365408&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk4m3328k443222q1%2F In this study, the influence of C m on burst firing behaviors of a two-compartment pyramidal neuron (including somatic compartment and dendritic compartment) was investigated by means of computer simulation, the value of C m in each compartment was denoted as C m,s and C m,d, respectively. Two cases were considered, in the first case, we let C m,s = C m,d, and then changed them simultaneously. While in the second case, we assumed C m,s ≠ C m,d, and then changed them, respectively. From the simulation results obtained from these two cases, it was found that the variation of C m in the somatic compartment and the dendritic compartment show much difference, simulated results obtained from the variation of C m,d have much more similarities than that of C m,s... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5365408 Sat, 29 Oct 2011 05:41:47 +0100 5365408 http://www.medworm.com/index.php?rid=5349693&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgtt4h1601265n833%2F Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s10072-011-0822-yAuthors L. Ferrari, Department of Neurology, Scientific Institute and University Hospital San Raffaele, 48, Via Olgettina, 20132 Milan, ItalyE. Coppi, Department of Neurology, Scientific Institute and University Hospital San Raffaele, 48, Via Olgettina, 20132 Milan, ItalyF. Caso, Department of Neurology, Scientific Institute and University Hospital San Raffaele, 48, Via Olgettina, 20132 Milan, ItalyR. Santangelo, Department of Neurology, Scientific Institute and University Hospital San Raffaele, 48, Via Olgettina, 20132 Milan, ItalyL. S. Politi, Department of Neuroradiology, Scientific Institute and University Hospital San Raffaele, 48, Via Olgettina, 20132 Milan, ItalyV. Martinelli, Departme... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5349693 Fri, 21 Oct 2011 16:00:32 +0100 5349693 http://www.medworm.com/index.php?rid=5338127&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F431283444154kun3%2F Abstract  Informed consent is often talked about in an abstract manner, as if consent and information necessarily have to go together, and almost as if consent is “naturally” the quintessence of a good professional relationship in modern medicine. The United States is considered as the place of origin of informed consent. In Italy the concept of informed consent can be found for the first time in the 1990s. Informed consent is based on the principles of autonomy and benefit, on awareness and information. Already at the moment of the diagnosis, in addition to motor deficits, focal cognitive deficits are often present. It is important for the doctor to consider and evaluate the actual ability to comprehend and process the clinical situation on the part of the patient. At ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5338127 Wed, 19 Oct 2011 15:44:17 +0100 5338127 http://www.medworm.com/index.php?rid=5338128&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu28578g187537137%2F Abstract  In patients with brain tumor, seizures are the onset symptom in 20–40% of the patients, while a further 20–45% of the patients will present them during the course of the disease. These data are important when considering the choice of antiepileptic drugs for this particular patient population, because brain tumor-related epilepsy (BTRE) is often drug resistant, has a strong impact on the quality of life and weighs heavily on public health expenditures. In brain tumor patients, the presence of epilepsy is considered as the most important risk factor for long-term disability. For this reason, the problem of the proper administration of medications and their potential side effects is of great importance, because good seizure control can significantly improve the ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5338128 Wed, 19 Oct 2011 15:44:16 +0100 5338128 http://www.medworm.com/index.php?rid=5338129&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft8g3065nqm4x5058%2F Abstract  The Chiari malformation (CM) is a syndrome embodied in heterogeneous groups of malformations, spanning from the more benign and known, the CM1, to more complex syndromes such as the rare association with the tethered cord, as spinal lipomas, and the CM2, associated to open spina bifida. The clinical picture may be well expressed and detected at birth or even during intrauterine life, as for CM2, but in the other cases they may run a rather subtle clinical course. The diagnosis of these syndromes is driven by clinical examination and MRI, and it usually requires a multidisciplinary approach in order to plan the therapeutic strategies, such as surgery. Among the diagnostic investigations, the imaging techniques represent the most useful, for their capabilities to de... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5338129 Wed, 19 Oct 2011 15:44:15 +0100 5338129 http://www.medworm.com/index.php?rid=5338130&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj1046106002ru165%2F In conclusion, the prognostic evaluation and the therapeutic strategies for patients depend on the synthesis of histological diagnosis, malignancy grade, gene-molecular profile, radiological images, surgical resection and clinical findings (age, tumour location, and “performance status”). Content Type Journal ArticlePages 1-3DOI 10.1007/s10072-011-0802-2Authors Bianca Pollo, Unit of Neuropathology, Fondazione IRCCS Istituto Neurologico “C. Besta”, Via Celoria 11, 20133 Milan, Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5338130 Tue, 18 Oct 2011 15:59:02 +0100 5338130 http://www.medworm.com/index.php?rid=5338131&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh31w1k0657212752%2F Abstract  The first formal description of the Shaking Palsy is ascribed to James Parkinson. However, a review of the literature shows that several civilizations had know this disease from long before, despite the fact it was often mistaken for other diseases. Equally, therapies of some effectiveness were prescribed since ancient times. Content Type Journal ArticleCategory History of NeurologyPages 1-4DOI 10.1007/s10072-011-0816-9Authors Francesco Raudino, Department of Neurology, Valduce Hospital, Via Dante 11, 22100 Como, Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5338131 Mon, 17 Oct 2011 16:03:20 +0100 5338131 http://www.medworm.com/index.php?rid=5338132&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F10223941m20740q0%2F We report a case of a 46-year-old man with memory deficit and behavioral changes followed by a rapid cognitive decline and pyramidal syndrome. Head magnetic resonance imaging showed cortical atrophy of the brain and symmetric corticospinal tract involvement. He died 4 years after the first symptoms. Autopsy was performed and the brain revealed cortical and corpus callosum atrophy, a grayish granular appearance of the white matter and ventricular enlargement. Myelin stains showed a significant demyelination of the centrum ovale and corticospinal tract. Such degeneration was accompanied by axonal loss, axonal swelling, and numerous spheroids. There was no pigment overload or inflammation. We discuss this new DLS case with bilateral, severe, and rapid cortical–spinal involvement.... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=5338132 Mon, 17 Oct 2011 16:03:18 +0100 5338132