MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Neurological Sciences' source. Wed, 17 Mar 2010 14:52:20 +0100 http://www.medworm.com/index.php?rid=3368064&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F3401137gt0717182%2F Abstract  A 54-year-old, right-handed male suffered sudden onset of vertigo and vomiting. He was diagnosed with brainstem hemorrhage, and treatment was administered. After the vertigo improved, he showed disturbance of attention and anterograde amnesia. Magnetic resonance imaging revealed a hematoma across the pons on both sides, but no lesions were obvious in the cerebellum or the cerebrum. Single photon emission tomography showed decreased perfusion not only in the brainstem but also in the bilateral frontal and temporal lobes. Amnesia and executive dysfunction decreased in the 8 months following the stroke onset, with improvement in regional cerebral blood flow to the frontal and temporal lobes. These findings suggest that a hemorrhage in the pons caused diaschisis ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3368064 Sun, 14 Mar 2010 11:29:24 +0100 3368064 http://www.medworm.com/index.php?rid=3368065&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa3572867l357323j%2F Abstract  Peripheral nerve involvement in dermatomyositis (DM) has been known as neuromyositis. However, the pathogenic mechanism is not clear, and the association between DM and peripheral neuropathy is still controversial. Our patient exhibited symptomatic polyneuropathy that was documented electrophysiologically in addition to typical features of DM. The sural nerve biopsy showed evidence of a continuing neuropathic process of axonal type. There was no finding of inflammatory cells infiltrating the vessels. Neither methylprednisolone nor intravenous immunoglobulin (IVIg) improved neurological symptoms including muscle weakness and sensory disturbance. Clinical, electrophysiological, and neuropathological features in our case demonstrate the association of DM and polyneur... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3368065 Sun, 14 Mar 2010 11:29:22 +0100 3368065 http://www.medworm.com/index.php?rid=3368066&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9736713168jp13u2%2F We present a 2-year experience of thrombolytic therapy (2006–2008) in the stroke unit of the University Hospital in Zagreb, Croatian largest hospital, serving nearly one-fifth of the citizens of Croatia. Obtained data (vitals at admission and before administration of rt-PA; NIHSS and MRS scores at admission, 2 h and 7th day after rt-PA treatment, “time to door” and “door to needle” intervals, duration of hospital treatment as well as outcomes and complications of our 66 thrombolysed patients) are presented and discussed. We also present our results regarding benefits of this therapy as well as possible reasons for complications noticed. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-010-0237-1Authors Vesna Matijević, University Hospital ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3368066 Sun, 14 Mar 2010 11:29:21 +0100 3368066 http://www.medworm.com/index.php?rid=3361029&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb2m31l31750610t2%2F Abstract  Radiolabeled metaiodobenzylguanidine (MIBG) is an analog of guanethidine and is taken up by the postganglionic presynaptic nerve endings. MIBG uptake in the heart correlates with adrenergic function, which can be reduced in Lewy body diseases. We described the recent developments in innervation imaging using 123I-MIBG scintigraphy in Lewy body diseases including Parkinson’s disease and dementia with Lewy bodies. Particularly, we underlined the role of MIBG scintigraphy in differential diagnosis of movement disorders. As described by recent studies, MIBG scintigraphy is a valuable diagnostic tool for differentiation between Lewy body diseases and parkinsonian syndromes or other movement disorders with parkinsonism. Furthermore, this method may provide a powerful d... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3361029 Thu, 11 Mar 2010 02:49:50 +0100 3361029 http://www.medworm.com/index.php?rid=3361030&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa6123734256r416l%2F Abstract  Parkinson’s disease (PD) is a neurodegenerative disorder, caused by reduced levels of catecholamines and oxidative stress. Symptoms seen in the disease include tremor, rigidity, bradykinesia and postural disability. Oxidative stress plays a key role in neurodegeneration and motor abnormalities seen in PD. Altered levels of the protein caused by these changes lead to defective ubiquitin–proteasome pathway. Neurodegeneration seen in PD and Canavan disease has a common mechanism. Recent studies suggest that herbal medicines can improve molecular changes and motor functions seen in PD. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s10072-010-0245-1Authors Sankar Surendran, LSUHSC School of Medicine New Orleans LA 70112 USASrinivasagam Rajasan... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3361030 Thu, 11 Mar 2010 02:49:49 +0100 3361030 http://www.medworm.com/index.php?rid=3356448&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw363118724058n88%2F Abstract  Semantically unique items are concrete entities characterized by a unique cluster of semantic information. In this field, neuropsychology has always given more attention to faces than to other kind of stimuli. An important category that has been largely neglected so far is famous buildings. A total of 200 healthy Italian adults with age, sex and education homogenously distributed across subgroups were administered a famous buildings naming and recognition test, which assessed both visual and verbal modalities. The test was divided in seven sections; norms were calculated taking into account demographic variables such as age, sex and education. Multiple regression analyses showed that education influenced significantly the performance on all subtests; age had a sig... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3356448 Wed, 10 Mar 2010 15:26:52 +0100 3356448 http://www.medworm.com/index.php?rid=3356452&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb17056x066081q7g%2F Abstract  Mutations in the presenilin 1 (PSEN1) gene are more commonly identified as genetic causes of early-onset familial Alzheimer’s disease than mutations in the amyloid precursor protein (APP) and the presenilin 2 (PSEN2) genes. More than 100 different mutations in the PSEN1 gene have been detected, and the clinical phenotypes have been described in the literature. This paper reports the case of a 38-year-old female showing early memory impairment and having a base pair mutation from guanine (G) to cytosine (C) at codon 139 of PSEN1, which leads to the substitution of a methionine with an isoleucine. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-010-0233-5Authors Hee-Jin Kim, Hanyang University Department of Neurology, College of Medicine 17 ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3356452 Wed, 10 Mar 2010 15:26:49 +0100 3356452 http://www.medworm.com/index.php?rid=3356451&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu7648052602pl2p1%2F Abstract  Patients affected by carpal tunnel syndrome (CTS) often report finding themselves “dropping objects”. This symptom is perceived as a severe and frustrating problem. We investigated the occurrence of “dropping objects” in a sample of 532 patients affected by CTS, studied with a multidimensional protocol (clinical, neurophysiological, and patient-oriented). To ensure that the definition of “dropping objects” was index of abnormality, we evaluated a control group interviewing 200 subjects. In order to evaluate if “dropping objects” was an index of more severe CTS impairment, we compared the severity measures between the patients with and without this condition. Severity of CTS multidimensionally assessed was significantly greater in patients with a hi... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3356451 Wed, 10 Mar 2010 15:26:49 +0100 3356451 http://www.medworm.com/index.php?rid=3356450&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4887311245229407%2F In this study, the effect of BBA was examined on neurites outgrowth and branching as well as on polymerization dynamics of tubulin. The morphometric parameters (axonal length and neuritis branching) were examined microscopically after treating the hippocampal cells with BBA. Also the assembly process of tubulin was assessed using UV/V is spectrophotometer through following of absorbance at 350 nm. The results revealed that BBA could significantly enhance neurite outgrowth, branching, and tubulin polymerization dynamics. The obtained results suggest that enhancing effect of BBA on microtubule polymerization kinetics might be the origin of increasing axonal outgrowth and branching. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-010-0220-xAuthors Ove... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3356450 Wed, 10 Mar 2010 15:26:49 +0100 3356450 http://www.medworm.com/index.php?rid=3356449&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc621v2wtq83q0m38%2F Abstract  To determine whether blockade of ionotropic glutamate receptors such as NMDA or AMPA receptors would attenuate blood–brain barrier (BBB) disruption in focal cerebral ischemia, 15 min before middle cerebral artery (MCA) occlusion, CGS-19755 or NBQX was injected intraperitoneally in rats. At 1 h after MCA occlusion, BBB permeability was determined by measuring the transfer coefficient (K i ) of 14C-α-aminoisobutyric acid and the volume of dextran distribution. With MCA occlusion, K i was increased in the ischemic cortex (IC) (316%). CGS-19755 attenuated the increase in K i in the IC (−46%), but NBQX did not significantly decrease it. The difference in the volume of dextran distribution between the IC and the contralateral cortex became insig... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3356449 Wed, 10 Mar 2010 15:26:49 +0100 3356449 http://www.medworm.com/index.php?rid=3356453&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F336lk07173075820%2F We report the original recipes applied to treat apoplexy in the eighteenth century, as written in the personal notes of doctor of that century. Content Type Journal ArticleCategory Brief CommunicationDOI 10.1007/s10072-010-0223-7Authors Biagio Arnone, Clinic Center, Private Hospital for Rehabilitation Naples ItalyClaudio Crisci, Clinic Center, Private Hospital for Rehabilitation Naples Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3356453 Wed, 10 Mar 2010 15:26:48 +0100 3356453 http://www.medworm.com/index.php?rid=3356454&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa43u6t53363315xk%2F We report the case of an idiopathic low CSF pressure presenting as a cough headache. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-010-0240-6Authors Angelo Nuti, Hospital of Viareggio Neurology Unit Lido di Camaiore LU ItalyFilippo Baldacci, University of Pisa Neurosciences Department Pisa ItalyClaudio Lucetti, Hospital of Viareggio Neurology Unit Lido di Camaiore LU ItalyCristina Dolciotti, Hospital of Viareggio Neurology Unit Lido di Camaiore LU ItalyGabriele Cipriani, Hospital of Viareggio Neurology Unit Lido di Camaiore LU ItalyUbaldo Bonuccelli, University of Pisa Neurosciences Department Pisa Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3356454 Wed, 10 Mar 2010 15:26:46 +0100 3356454 http://www.medworm.com/index.php?rid=3356456&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fhk1n48q402j85231%2F Abstract  Enhanced production of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in diabetes leads to degradation of extracellular matrix in blood vessels and leads to complications of diabetes. In the present study, we have targeted MMP-2 and MMP-9 overactivation in diabetic neuropathy using a known MMP-2 and MMP-9 inhibitor, minocycline, with a non-selective COX inhibitor, aspirin. Streptozotocin-induced diabetic neuropathy was carried out in male Wistar rats and monitored by measuring the sensory nerve conduction velocity (SNCV), motor nerve conduction velocity (MNCV), tail flick latency and hot plate latency. Three weeks of treatment with a combination of minocycline and aspirin showed significant improvement in SNCV, MNCV, hot plate latency an... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3356456 Wed, 10 Mar 2010 15:26:45 +0100 3356456 http://www.medworm.com/index.php?rid=3356455&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr0u810548132h354%2F Abstract  Alzheimer’s disease (AD) is a degenerative dementia characterized by typical, destructive alterations of neurons (neurofibrillary tangles and amyloid plaques), and glial proliferation. Cytokine-driven inflammatory environment can contribute to the pathogenesis and/or progression of the disease. The aim of the study was to evaluate and compare genotypic and allelic polymorphisms of 13 cytokine genes in 19 Caucasoid AD patients with medium–high level of dementia (assessed by an MMSE < 24) and 20 normal controls affected by non inflammatory neuropsychiatric disease. Polymorphisms in the genes of IL-lA, IL-lB, IL-2, IL-4, IL-6, IL-10, IL-12, IFN-G, TGF-β, TNF-α, and of the cytokine receptors IL-lR, IL-IRA, IL-4RA were investigated. APO-E and ACE gene... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3356455 Wed, 10 Mar 2010 15:26:45 +0100 3356455 http://www.medworm.com/index.php?rid=3336938&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6787561p06v63243%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10072-010-0235-3Authors Sevda Erer-Ozbek, Uludag University School of Medicine Department of Neurology 16059 Bursa TurkeyIbrahim Bora, Uludag University School of Medicine Department of Neurology 16059 Bursa TurkeySukran Yurtogullar, Uludag University School of Medicine Department of Neurology 16059 Bursa Turkey Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3336938 Wed, 03 Mar 2010 08:51:38 +0100 3336938 http://www.medworm.com/index.php?rid=3336941&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Flm6714r5w8437783%2F Abstract  A 49-year-old female presented with recurrent intolerable right retro-orbital pain, ptosis and diplopia for 4 months. Neurological evaluation revealed right oculomotor nerve and abducent nerve injuries. Neuroimaging found enlarged right cavernous sinus, right intracavernous carotid dissection aneurysm and a stenosis proximal to it. Tolosa–Hunt syndrome (THS) was suggested and treated with steroid. The clinical symptoms were alleviated after the treatment. After 3 months of follow-up cerebral angiography showed the lesions of the right intracavernous carotid stenosis and the dissection almost disappeared. Therefore, we proposed that the dissection and the stenosis are directly induced by the inflammation of THS. Content Type Journal ArticleCategory ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3336941 Wed, 03 Mar 2010 08:51:36 +0100 3336941 http://www.medworm.com/index.php?rid=3336940&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvx4367834074010n%2F We report a case of VKH disease with panuveitis and meningeal involvement of the anterior temporal lobe detected by brain MRI. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-010-0236-2Authors Hyun Jeong Han, Kwandong University Department of Neurology, College of Medicine, Myongji Hospital 697-24 Hawjeong-dong, Deukyang-gu, Goyang-shi Gyeonggi-do KoreaHye Yun Kim, Kwandong University Department of Neurology, College of Medicine, Myongji Hospital 697-24 Hawjeong-dong, Deukyang-gu, Goyang-shi Gyeonggi-do KoreaJong-Ho Park, Kwandong University Department of Neurology, College of Medicine, Myongji Hospital 697-24 Hawjeong-dong, Deukyang-gu, Goyang-shi Gyeonggi-do KoreaEun Ja Lee, Kwandong University Department of Radiology, College of Medicine, Myongji Hospital Gyeo... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3336940 Wed, 03 Mar 2010 08:51:36 +0100 3336940 http://www.medworm.com/index.php?rid=3336939&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F516887k7g7352457%2F This report provides the first documentation in the literature of a hemangiopericytoma colliding with a meningioma, and recurring after treatment with gross total resection. Surgical samples were fully evaluated with hematoxylin and eosin and reticulin staining, as well as immunohistochemical analysis. Results were classically representative of a hemangiopericytoma (World Health Organization grade II) and of a meningioma (World Health Organization grade I). This report of a unique collision tumor not only augments the repertoire of collision tumor combinations described in literature but also provides follow-up on the clinical outcome of the patient, thereby raising clinically relevant issues ranging from presentation to treatment paradigms. Content Type Journal ArticleCategory ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3336939 Wed, 03 Mar 2010 08:51:36 +0100 3336939 http://www.medworm.com/index.php?rid=3336942&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4717gx22mr2w5j06%2F Abstract  Alzheimer’s disease (AD) is the leading cause of dementia. Several studies indicate a possible relationship between different genes and Alzheimer’s disease. To further investigate, we have analyzed the association between the bleomycin hydrolase (BLMH) and apolipoprotein E (ApoE) polymorphisms in 93 AD patients and age- and sex-matched 113 controls from the Tunisian population. The frequency of ApoE epsilon 4 allele was found to differ significantly in AD patients compared to the control [29.5% vs. 8.8 (χ 2 = 26, df = 1, p < 0.001)] leading to an increased risk of AD in subjects with this allele (OR = 3.29, 95% CI = 1.7–6.5; p = 0.001]. This risk was found to decrease from OR = 8.4, CI&... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3336942 Wed, 03 Mar 2010 08:51:35 +0100 3336942 http://www.medworm.com/index.php?rid=3336943&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F34884150612874l1%2F This study was aimed to investigate the effects of resection of the nerves bundle from the SPG of rat on the brain lesions following middle cerebral artery occlusion (MCAO), and evaluated the roles of the nitric oxygen synthase (NOS) immunoreactive perivascular nerves of cerebral arteries in MCAO. We found that 7 days after bilateral resections of the nerves bundle from the SPG, the NOS activity perivascular nerves in the middle cerebral arteries disappeared, and the infarction volume and the TUNEL positive cells increased significantly after 24 h MCAO, which implicated that the NOS contained nerves from the SPG maybe have an important role in the MCAO. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-010-0238-0Authors Su Diansan, Shanghai Jiaot... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3336943 Wed, 03 Mar 2010 08:51:33 +0100 3336943 http://www.medworm.com/index.php?rid=3313235&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F675258263w1p5786%2F Abstract  The association of chronic migraine (CM) with an idiopathic intracranial hypertension without papilledema (IIHWOP), although much more prevalent than expected in clinical series of CM sufferers, is not included among the risk factors for migraine progression. We discuss the available evidence supporting the existence of a pathogenetic link between CM and idiopathic intracranial hypertensive disorders and suggest a causative role for IIHWOP in migraine progression. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s10072-010-0229-1Authors Roberto De Simone, University of Naples “Federico II” Headache Centre, Department of Neurological Sciences via Pansini, 5 80131 Naples ItalyAngelo Ranieri, University of Naples “Federico II” Headache Centr... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3313235 Thu, 25 Feb 2010 06:54:37 +0100 3313235 http://www.medworm.com/index.php?rid=3313234&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe26661276h543449%2F The objective is to evaluate the prognosis of subjective cognitive complaints (SCC) patients during 4-year follow-up. A prospective study on 92 SCC patients investigating their cognitive, affective and behavioural aspects. SCC patients were classified as having no objective cognitive impairment (NOCI), mild cognitive impairment (MCI), or subtypes of MCI. Results: 43 patients were found to have NOCI and 49 MCI. During the follow-up, 45.5% of NOCI patients remained unchanged, 13.9% were diagnosed as MCI and only one progressed to dementia. Of the MCI patients, 32.3% remained stable, 18.4% became demented and 4% reverted to NOCI. Visual attention, behavioural memory, long-term verbal memory, apathy and caregiver distress, provided independent predictors of progression to dementia. ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3313234 Thu, 25 Feb 2010 06:54:37 +0100 3313234 http://www.medworm.com/index.php?rid=3313233&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fnh4t24386nx17272%2F Abstract  Auditory cueing enhances gait in parkinsonian patients. Our aim was to evaluate its effects on spatiotemporal (stride length, stride time, cadence, gait speed, single and double support duration) kinematic (range of amplitude of the hip, knee and ankle joint angles registered in the sagittal plane) and kinetic (maximal values of the hip and ankle joint power) gait parameters using three-dimensional motion analysis. Eight parkinsonian patients performed 12 walking tests: 3 repetitions of 4 conditions (normal walking, 90, 100, and 110% of the mean cadence at preferred pace cued walking). Subjects were asked to uniform their cadence to the cueing rhythm. In the presence of auditory cues stride length, cadence, gait speed and ratio single/double support duration incre... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3313233 Thu, 25 Feb 2010 06:54:37 +0100 3313233 http://www.medworm.com/index.php?rid=3313236&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm4j618471u6g3532%2F We describe the case of a 59-year-old homosexual man with a 1-month history of decreased vision acuity in his left eye who was diagnosed with neurosyphilis and received treatment with intravenous penicillin G (16 million units in divided daily doses), with great improvement of visual acuity and CSF examination findings. The interest of this case is not only represented by the unusually early ocular involvement, but also by the rapid evolution of the disease into the secondary stage in a man who had had one at-risk homosexual relationship only 3 months before the onset symptoms. We also support the view that the presence of ocular involvement in syphilitic patients is suggestive of involvement of the CNS and should be considered synonymous with neurosyphilis. Content Type Jo... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3313236 Thu, 25 Feb 2010 06:54:35 +0100 3313236 http://www.medworm.com/index.php?rid=3313238&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl5857w3741277067%2F We present a case of a 25-year-old male with severe headaches associated with exertion and sexual intercourse with vasoconstriction on magnetic resonance and CT angiograms done during his typical headaches. The headache syndrome and angiographic findings resolved after starting low-dose verapamil. Perhaps, some cases of primary exertional and primary headaches associated with sexual activity are associated with reversible cerebral vasoconstriction responsive to calcium channel blockers. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-010-0226-4Authors Brett J. Theeler, William Beaumont Army Medical Center, Medical Corps, United States Army Department of Medicine/Neurology Service 5005 N. Piedras, Fort Bliss El Paso TX 79920 USAMichael V. Krasnokutsky, Madigan A... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3313238 Thu, 25 Feb 2010 06:54:33 +0100 3313238 http://www.medworm.com/index.php?rid=3313237&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv1w720q8756wjq00%2F Content Type Journal ArticleCategory Book ReviewDOI 10.1007/s10072-010-0230-8Authors Anna Rita Giovagnoli, Fondazione Istituto Neurologico Carlo Besta Milan Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3313237 Thu, 25 Feb 2010 06:54:33 +0100 3313237 http://www.medworm.com/index.php?rid=3274222&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn5523684081507r0%2F Abstract  Meta-iodbenzylguanidine scintigraphy (MIBG scintigraphy) shows reduced uptake in idiopathic Parkinson’s disease (IPD), idiopathic REM sleep behavior disorder (IRBD) and Lewy body dementia (LBD), but not in other parkinsonian or dementia syndromes. We retrospectively reevaluated 50 patients. Concordance rate between last clinical diagnosis and scintigraphy diagnosis was only given in two-thirds of the patients. Confounding factors were: decreasing heart/mediastinum ratio (HMR) with progressive age, higher HMR in women and possibly interference with antihypertensive medication. Standardization of the methods and precise clinical guidelines are warranted for better clinical use. Content Type Journal ArticleCategory Brief CommunicationDOI 10.1007/s10072-010-0218-4... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3274222 Sat, 13 Feb 2010 06:48:08 +0100 3274222 http://www.medworm.com/index.php?rid=3270507&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg0036l44626276wu%2F Abstract  Central pontine myelinolysis is an acquired, non-inflammatory demyelinating lesion usually localized in the brainstem pons basis; it usually affects patients with a history of chronic alcoholism, malnutrition or dysionemia. The exact pathogenesis of myelinolysis is still unclear. A 69-year-old Caucasian male presented intensive headache and underwent cranial MRI that showed the typical feature of central pontine myelinolysis. Neurological valuation was negative. Other examinations included extensive blood tests, electroencephalogram and multimodal evoked potentials which all gave normal results. Alcohol abuse and malabsorption syndrome were excluded. The medical history revealed a continuative use of anti-depressive drugs and exposure to glue for years. Our patien... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3270507 Thu, 11 Feb 2010 11:48:55 +0100 3270507 http://www.medworm.com/index.php?rid=3264698&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9wk2458050626516%2F Abstract  The carpal tunnel syndrome is a compressive neuropathy with high incidence rates, and its correct diagnosis, treatment and follow-up may lead to significant benefits in healthcare, social and economic terms. In this review, based on systematic review databases and guidelines, we summarise the appropriate indications for the diagnosis, treatment and follow-up, accompanied, whenever possible, by the levels of evidence and strength of recommendations. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s10072-009-0213-9Authors Calogero Alfonso, Azienda Ospedaliera di Bologna Policlinico S. Orsola-Malpighi U.O. Ortopedia e Traumatologia Via Albertoni, 15 40141 Bologna ItalyStefano Jann, A.O. Ospedale Maggiore Niguarda U.O. Neurologia Piazza Ospedale Maggi... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3264698 Tue, 09 Feb 2010 17:45:13 +0100 3264698 http://www.medworm.com/index.php?rid=3247990&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9886260884660w68%2F We report on two patients displaying flexion AM jerks in the absence of structural lesion of the central nervous system or electrophysiological evidence of organic origin. A conversion disorder was diagnosed. The jerks disappeared after psychoeducation with the patients remaining symptom free in 6-year long follow-up. The diagnoses of psychogenic axial (propriospinal-like) myoclonus were established. The literature on psychogenic axial (propriospinal-like myoclonus) is limited to a case report. Our cases demonstrate a good response to psychotropic medication and psychoeducation and fulfill the psychogenic movement disorder criteria. The phenomenology of psychogenic abnormal movements is diverse and PSM-like clinical picture may be a novel presentation. Content Type Journal Article... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3247990 Thu, 04 Feb 2010 18:11:45 +0100 3247990 http://www.medworm.com/index.php?rid=3247991&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg7j3068639576108%2F Abstract  Two patients with uncontrollable aggressive behaviour underwent the placement of stimulating leads in the posterior hypothalamus (pHyp). One patient had also multifocal refractory epilepsy. Microrecordings were obtained in both patients during surgery under general anaesthesia. Firing rate, interspike intervals and oscillatory discharge patterns were analysed in 14 neurons. A mean discharge rate of 19 Hz, and oscillatory activity at 7–8 Hz were recorded in the first patient with aggressiveness and epilepsy. In the second patient the mean firing rate was 10 Hz, with evidence of both tonic and random firing patterns. Previous studies in patients with cluster headache showed that a discharge rate around 20 Hz and lack of a specific rhythmic patt... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3247991 Thu, 04 Feb 2010 18:11:44 +0100 3247991 http://www.medworm.com/index.php?rid=3241614&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft7k3h54720263817%2F This study examined whether HO-1 can be induced by MPP+ and whether HO-1 has a protective role against the MPP+-induced cytotoxicity in PC-12 cells. MPP+ triggered a relatively rapid induction of HO-1. The MPP+-induced cytotoxicity and reactive oxygen species (ROS) production markedly increased by HO-1 inhibitor, zinc protoporphyrin-IX (ZnPP-IX). The increase of ROS production by ZnPP-IX was completely abrogated by either two products of HO (biliverdin or bilirubin) while the increase of cytotoxicity by ZnPP-IX was attenuated partially. These suggest that HO-1 expression might have some cytoprotective effect against MPP+-induced cytotoxicity. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-010-0216-6Authors Jung-Woo Bae, Sungkyunkwan University Laboratory o... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3241614 Wed, 03 Feb 2010 06:49:23 +0100 3241614 http://www.medworm.com/index.php?rid=3241615&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj591224h8210l650%2F Abstract  Obsessive compulsive disorder is a highly disabling pathological condition which in the most severe and drug-resistant form can severely impair social, cognitive and interpersonal functioning. Deep-brain stimulation has been demonstrated to be an effective and safe interventional procedure in such refractory forms in selected cases. We here report the first Italian experience in the treatment of this pathology by means of nucleus accumbens stimulation, pointing out to some technical data which could be of help in localization of the target. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0214-8Authors Angelo Franzini, Fondazione Istituto Nazionale Neurologico “Carlo Besta” Via Caloria 11 20133 Milan ItalyGiuseppe Messina, Fondazione I... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3241615 Wed, 03 Feb 2010 06:49:20 +0100 3241615 http://www.medworm.com/index.php?rid=3229309&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk070n26244723842%2F In conclusion, this study suggests an association between short-term outdoor air pollution exposure and ischemic stroke admission and mortality. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-009-0206-8Authors Simone Vidale, Sant’Anna Hospital Neurology Department Via Napoleona 60 22100 Como ItalyA. Bonanomi, Cattolica Sacro Cuore University Statistic Sciences Department Milan ItalyM. Guidotti, Valduce Hospital Neurology Department Como ItalyM. Arnaboldi, Sant’Anna Hospital Neurology Department Via Napoleona 60 22100 Como ItalyR. Sterzi, Niguarda Ca’ Granda Hospital Neurology Department Milan Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3229309 Sat, 30 Jan 2010 18:13:01 +0100 3229309 http://www.medworm.com/index.php?rid=3229308&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu231672776104787%2F Abstract  The rare case of a patient with SIADH following pituitary adenoma apoplexy is reported. Since apoplexy did not exert any mass effect on surrounding structures, the patient was treated conservatively and the anterior pituitary gland insufficiency has been substituted adequately. Seven days after the apoplexy the patient again showed low serum–Na+ levels despite cortisol substitution. Diagnosis of SIADH was made. It is essential to be aware of this rare syndrome in patients with pituitary adenoma apoplexy. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0210-zAuthors Florian Heinrich Ebner, Eberhard-Karls-University Hospital Tübingen Department of Neurosurgery Hoppe-Seyler-Straße 3 72076 Tübingen GermanyTill K. Hauser, Eberhard-Karls-Un... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3229308 Sat, 30 Jan 2010 18:13:01 +0100 3229308 http://www.medworm.com/index.php?rid=3229311&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj263ur2j24331814%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10072-009-0212-xAuthors Ozlem Kayim Yildiz, Cumhuriyet University School of Medicine Department of Neurology 58140 Sivas TurkeyHatice Segmen, Cumhuriyet University School of Medicine Department of Neurology 58140 Sivas TurkeyIbrahim Oztoprak, Cumhuriyet University School of Medicine Department of Radiology 58140 Sivas TurkeyErtugrul Bolayir, Cumhuriyet University School of Medicine Department of Neurology 58140 Sivas TurkeySuat Topaktas, Cumhuriyet University School of Medicine Department of Neurology 58140 Sivas Turkey Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3229311 Sat, 30 Jan 2010 18:13:00 +0100 3229311 http://www.medworm.com/index.php?rid=3229310&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ftlk4404005771157%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10072-009-0208-6Authors Kamyar Ghabili, Tabriz University of Medical Sciences Tuberculosis and Lung Diseases Research Center Golgasht St. Tabriz IranMohammadali M. Shoja, Indianapolis Neurosurgical Group, Clarian Neuroscience Institute Indianapolis IN USAR. Shane Tubbs, Children’s Hospital Section of Pediatric Neurosurgery Birmingham AL USAAaron A. Cohen-Gadol, Indianapolis Neurosurgical Group, Clarian Neuroscience Institute Indianapolis IN USA Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3229310 Sat, 30 Jan 2010 18:13:00 +0100 3229310 http://www.medworm.com/index.php?rid=3229312&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F248371l7424k34j8%2F We describe the case of a patient with NBD studied with conventional and diffusion weighted MR imaging. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0205-9Authors Luisa Vuolo, University of Genoa DINOG, Department of Neurosciences, Ophthalmology and Genetics Via De Toni, 5 16132 Genoa ItalyLaura Bonzano, University of Genoa DINOG, Department of Neurosciences, Ophthalmology and Genetics Via De Toni, 5 16132 Genoa ItalyCaterina Roccatagliata, Azienda Sanitaria Locale 3 Genoa ItalyRoberto Carlo Parodi, San Martino Hospital Neuroradiology Unit Genoa ItalyLuca Roccatagliata, University of Genoa DINOG, Department of Neurosciences, Ophthalmology and Genetics Via De Toni, 5 16132 Genoa Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-187... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3229312 Sat, 30 Jan 2010 18:12:58 +0100 3229312 http://www.medworm.com/index.php?rid=3229313&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh833p86p62r67671%2F We report the case of a 32-year-old woman with a history of increased sleep need and difficulty waking up; the diagnosis of idiopathic hypersomnia was hypothesized. During ambulatory polysomnography (PSG), the patient presented an episode characterized by loss of consciousness and jerking of the four limbs. A video-PSG monitoring was performed and the patient showed unresponsiveness and drowsiness at 7 a.m. During the episode, EEG showed theta–delta diffuse activity, and blood glucose level was 32 mg dl−1. The diagnosis of insulinoma was then assumed; CT scan showed a hypodense mass into the pancreatic tail, and a partial pancreasectomy was performed. The described symptoms disappeared, and 5 years later the findings of a complete clinical and neurophysiological... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3229313 Sat, 30 Jan 2010 18:12:55 +0100 3229313 http://www.medworm.com/index.php?rid=3229314&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr14151mmv5355211%2F Abstract  Sydenham’s chorea (SC) is the neurologic manifestation of rheumatic fever. In addition to involuntary movements, SC patients show behavioral changes, such as hyperactivity, obsessions, and compulsions. Brain-derived neurotrophic factor (BDNF) is related to neuronal development and differentiation. Since BDNF serum levels are altered in a series of neuropsychiatric disorders, such as schizophrenia and Huntington’s disease, we investigated the serum levels of BDNF in SC patients. Eighteen patients with acute SC, 4 with persistent SC and 27 control subjects were included in this study. BDNF was determined by ELISA. There was no significant difference between BDNF serum levels of control and acute SC groups (P = 0.12). Persistent SC patients presented dec... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3229314 Fri, 29 Jan 2010 12:16:43 +0100 3229314 http://www.medworm.com/index.php?rid=3229315&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg132l7253047q056%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10072-009-0203-yAuthors Fabio Poglio, AOU San Giovanni Battista Neurologia IV, Dipartimento di Neuroscienze Via Cherasco 15 10126 Turin ItalyIlaria Paolasso, AOU San Giovanni Battista Neurologia IV, Dipartimento di Neuroscienze Via Cherasco 15 10126 Turin ItalyYolanda Falcone, AOU San Giovanni Battista Neurologia IV, Dipartimento di Neuroscienze Via Cherasco 15 10126 Turin ItalySerena Grimaldi, AOU San Giovanni Battista Neurologia IV, Dipartimento di Neuroscienze Via Cherasco 15 10126 Turin ItalyDario Cocito, AOU San Giovanni Battista Neurologia IV, Dipartimento di Neuroscienze Via Cherasco 15 10126 Turin Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Science... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3229315 Fri, 29 Jan 2010 12:16:40 +0100 3229315 http://www.medworm.com/index.php?rid=3191248&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjn775104706k1p4u%2F In conclusion, vertebroplasty is a safe and efficient procedure in the treatment of painful vertebral body fractures in patients with multiple myeloma, without potential contraindications, such as fractures of the posterior wall or epidural disease. We also treated three and more levels in 28% of cases in a single session without complications. Due to the early pain relief and the low complication rate, it is possible to expand the indication to vertebroplasty for the prophylactic augmentation of those vertebral bodies at risk of fracture in which significant neoplastic substitution of the body is present. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-009-0197-5Authors Flavio Tancioni, Instituto Clinico Humanitas Department of Neurosurgery Milan ItalyMart... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3191248 Fri, 15 Jan 2010 00:42:57 +0100 3191248 http://www.medworm.com/index.php?rid=3191249&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2172472558nh5466%2F Abstract  HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy, usually with adult-onset. Very few cases of childhood-onset have been described, most presenting with progressive paraparesis and sphincteric disturbances as in the adult form. Here we report a young male with childhood-onset of HAM/TSP and progressive cognitive and behavioral disturbances. A serological screening revealed HTLV-I infection, confirmed by Western Immunoblotting analysis. Molecular characterization of amplified HTLV-I proviral DNA has been performed both in the patient and his mother by LTR sequence analysis, and HLA genotype inheritance was evaluated. Our case indicates the possibility that cognitive dysfunctions may be one manifestation of HTLV-I infection ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3191249 Fri, 15 Jan 2010 00:42:56 +0100 3191249 http://www.medworm.com/index.php?rid=3169354&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv42h273663216572%2F Abstract  A case of avascular necrosis of whirlbone in a young man affected by multiple sclerosis and treated with high doses of corticosteroids is described. The authors discuss the causes of this collateral effect underlining the risks of underevaluating the symptoms. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0177-9Authors Edvina Galiè, Istituto Nazionale Tumori Regina Elena Division of Neurology Via Chianesi 53 00144 Rome ItalyBruno Jandolo, Istituto Nazionale Tumori Regina Elena Division of Neurology Via Chianesi 53 00144 Rome Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3169354 Tue, 12 Jan 2010 06:44:48 +0100 3169354 http://www.medworm.com/index.php?rid=3122812&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fw200k6n3k243206k%2F This study investigated the possible involvement of matrix metalloproteinase 9 (MMP-9) in early brain injury (EBI) of subarachnoid hemorrhage (SAH) in rats. MMP-9 activities in hippocampus were examined at 6, 12, 24, 48 and 72 h after SAH. Laminin was detected by immunohistochemistry. Apoptosis of neurons in hippocampus was observed by TUNEL. Brain water content was also examined. MMP-9 activity and the number of apoptotic neurons increased from 12 to 72 h with a peak at 24 h. Laminin was found to decrease at 12 h, reached minimum at 24 h and began to increase from 48 h, which had a negative correlation with apoptotic neurons. The changes of brain water content were found to be coincidence with that of neuronal apoptosis. Our findings suggest that MMP-9 ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3122812 Thu, 24 Dec 2009 19:57:49 +0100 3122812 http://www.medworm.com/index.php?rid=3122813&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fdgl8822133036384%2F In conclusion, migraine with aura appears to be associated with ischemic stroke in young women, independently from other common risk factors. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-009-0195-7Authors Massimo Camerlingo, Policlinico San Marco Neurological Unit Corso Europa 7 24040 Osio Sotto Bergamo ItalyA. Romorini, Presidio Ospedaliero Neurological Unit Magenta Milano ItalyC. Ferrante, Policlinico San Marco Neurological Unit Corso Europa 7 24040 Osio Sotto Bergamo ItalyL. Valente, Policlinico San Marco Neurological Unit Corso Europa 7 24040 Osio Sotto Bergamo ItalyL. Moschini, Policlinico San Marco Neurological Unit Corso Europa 7 24040 Osio Sotto Bergamo Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neur... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3122813 Thu, 24 Dec 2009 19:57:48 +0100 3122813 http://www.medworm.com/index.php?rid=3106062&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh17543uk563k2308%2F We report the results of the natural history of clinical features and quality of life (QoL) in patients with CMT2. Twenty patients were enrolled. At recruitment and at follow-up (2 years), all patients underwent neurological evaluation, QoL and disability assessments. The study-end evaluation took place 20–28 months after the baseline evaluation. During the 2-year follow-up period, CMT2 patients showed a mild reduction of strength of distal muscles of upper limbs and proximal muscles of lower limbs, a worsening sensory function and a mild increase in walking disability. However, there was no relevant worsening of QoL, except for a mild deterioration of one mental health domain. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-009-0202-zAuthors ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3106062 Thu, 17 Dec 2009 07:04:15 +0100 3106062 http://www.medworm.com/index.php?rid=3086932&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fb44h6q650762u310%2F Abstract  The aim of this study is to assess the reported quality of randomized controlled trials (RCTs) on the effectiveness of neglect rehabilitation using a standardized scale. A search of seven electronic databases was carried out. Selected articles were scored using the PEDro scale and classified as high or low quality study both with the original cut off of 6 and a modified cut off of 5. A linear regression analysis between year of publication and quality rate was used to test whether the quality of the studies improved with time. A total of 18 RCTs were selected. Six articles (33.3%) and 10 articles (55.56%) were classified as having high quality when the original cut off or the modified cut off of the PEDro scale were used, respectively. Analysis shows no time-relat... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3086932 Thu, 10 Dec 2009 15:19:15 +0100 3086932 http://www.medworm.com/index.php?rid=3064968&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp4t726055307v703%2F We report a patient with acute subdural hemorrhage associated with rifampicin-induced thrombocytopenia. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0187-7Authors Sa-Yoon Kang, Cheju National University Department of Neurology, College of Medicine Jeju South KoreaJay Chol Choi, Cheju National University Department of Neurology, College of Medicine Jeju South KoreaJi-Hoon Kang, Cheju National University Department of Neurology, College of Medicine Jeju South KoreaJung Seok Lee, Cheju National University Department of Neurology, College of Medicine Jeju South Korea Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3064968 Fri, 04 Dec 2009 07:19:49 +0100 3064968 http://www.medworm.com/index.php?rid=3064969&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr4184618401x603q%2F Abstract  Inflammation is a key component of Alzheimer’s disease (AD), and we have examined the effect of two polymorphisms (−174G/C and −572C/G) in the promoter of the inflammatory cytokine interleukin-6 (IL-6) gene on risk of AD in 318 AD patients. Significant differences in genotype and allele frequencies of −572C/G IL-6 promoter polymorphism were observed between AD patients and controls. The GG genotype was associated with a decreased risk of developing AD (OR 0.423, 95% CI 0.200–0.894). Similarly, logistic regression analysis revealed that G allele was a protective factor for AD (OR 0.732, 95% CI 0.567–0.945). For −174G/C variability, no C variability was found in all the subjects. The frequency of the IL-6 −174G/C promoter polymorphism is very low or ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3064969 Thu, 03 Dec 2009 12:50:05 +0100 3064969 http://www.medworm.com/index.php?rid=3064970&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh463883410h7126n%2F Abstract  Semaphorins of the SemaIV family are expressed in neurons and decreased in brains from patients with Alzheimer’s disease (AD). Accumulation of an internalized form of Sema3A is associated with degeneration of neurons, making these molecules candidates for the development of AD. Single nucleotide polymorphisms (SNPs) rs36026860 and rs28469467 in Sema3A as well as rs13284404 and rs11526468 in Sema4D were analyzed in a population of 240 patients with AD compared with 222 age-matched controls. None of SNPs in Sema3A were present, either in patients or controls. The distribution of the Sema4D rs11526468 and rs13284404 SNPs was not significantly different between patients and controls, even stratifying for gender or age at onset. In silico analysis predicted that rs11526... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3064970 Thu, 03 Dec 2009 12:50:04 +0100 3064970 http://www.medworm.com/index.php?rid=3064971&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk582v716978g0k60%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10072-009-0193-9Authors Pasquale Striano, University of Genova Muscular and Neurodegenerative Diseases Unit, G. Gaslini Institute Genova ItalyElena D’Amato, University of Genova Department of Paediatrics, G. Gaslini Institute Genova ItalyMarianna Pezzella, Federico II University Epilepsy Center Naples ItalyPaolo Mainardi, University of Genova Department of Neurosciences, Ophthalmology and Genetics, Ospedale S. Martino Genova ItalyFederico Zara, University of Genova Muscular and Neurodegenerative Diseases Unit, G. Gaslini Institute Genova ItalySalvatore Striano, Federico II University Epilepsy Center Naples Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Scie... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3064971 Tue, 01 Dec 2009 21:01:20 +0100 3064971 http://www.medworm.com/index.php?rid=3064972&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft9617l724l76x890%2F Abstract  Juvenile myoclonic epilepsy (JME) is a genetically determined common subtype of idiopathic generalized epilepsy. Linkage of JME to the chromosomal region 6p21.3 has been reported. An association has been previously observed between JME and the positional candidate, 6p21.3 linked, BRD2. Another candidate in this region is the TAP-1 gene encoding the Transporter Associated with Antigen Processing. The aim of the present study is to determine whether these two genes modulate the vulnerability to JME. While no difference was observed in the allele and genotype frequencies of BRD2 between JME and controls, an association was found between a TAP-1 haplotype and JME, suggesting that this gene may be another 6p21.3 linked vulnerability factor to JME. Content Type Journal... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3064972 Tue, 01 Dec 2009 21:01:18 +0100 3064972 http://www.medworm.com/index.php?rid=3064973&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj8m5648224017580%2F Abstract  Phenotype of patients with the aprataxin gene mutation varies and according to previous studies, screening of aprataxin gene could be useful, once frataxin gene mutation is excluded in patients with normal GAA expansion in frataxin gene. In the present study, we sought to determine possible causative mutations in aprataxin gene (all exons and flanking intronic sequences) in 14 Greek patients with sporadic cerebellar ataxia all but one without GAA expansion in frataxin gene (1 patient was heterozygous). No detectable point mutation or deletion was found in the aprataxin gene of all the patients. Our results do not confirm the previous studies. This difference may be attributed to the different populations studied and possible different genetic background. It is sti... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3064973 Tue, 01 Dec 2009 21:01:16 +0100 3064973 http://www.medworm.com/index.php?rid=3041804&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu3523r3723777469%2F We reported a case of good maternal and fetal outcomes of predominantly sensory GBS (generalized pain and numbness, mild deep sensory ataxia, positive serum IgM anti-GalNAcGD1a antibody)-complicating pregnancy after intravenous immunoglobulin treatment. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0188-6Authors Yasuo Matsuzawa, Toho University Respiratory Diseases Division, Department of Internal Medicine, Sakura Medical Center Sakura JapanRyuji Sakakibara, Toho University Neurology Division, Department of Internal Medicine, Sakura Medical Center 564-1 Shimoshizu Sakura 285-8741 JapanToshiko Shoda, Toho University Respiratory Diseases Division, Department of Internal Medicine, Sakura Medical Center Sakura JapanMasahiko Kishi, Toho University Neurology Divis... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3041804 Wed, 25 Nov 2009 16:50:49 +0100 3041804 http://www.medworm.com/index.php?rid=3032236&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1qw14l010k084458%2F Content Type Journal ArticleCategory ErratumDOI 10.1007/s10072-009-0196-6Authors Alessandro Consales, Gaslini Children’s Hospital Department of Neurosurgery Genoa ItalyGianluca Piatelli, Gaslini Children’s Hospital Department of Neurosurgery Genoa ItalyMarcello Ravegnani, Gaslini Children’s Hospital Department of Neurosurgery Genoa ItalyMarco Pavanello, Gaslini Children’s Hospital Department of Neurosurgery Genoa ItalyPasquale Striano, Gaslini Children’s Hospital Department of Muscular and Neurodegenerative Diseases Genoa ItalyMaria Luisa Zoli, National Health Service Department of Assistance for the Disabled Genoa ItalyValeria Capra, Gaslini Children’s Hospital Department of Neurosurgery Genoa ItalyAndrea Rossi, Gaslini Children’s Hospital Department of Neuroradiology Ge... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3032236 Tue, 24 Nov 2009 07:10:27 +0100 3032236 http://www.medworm.com/index.php?rid=3032237&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg827q567g2038346%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10072-009-0186-8Authors Andrea Calvo, University of Torino Section of Neurology, Department of Neuroscience Via Cherasco 15 10126 Turin ItalyFranco Benech, University of Torino Section of Neurosurgery, Department of Neuroscience Turin ItalyPaolo Ghiglione, Ospedale Maggiore Savigliano ItalyMichele Balma, University of Torino Section of Neurology, Department of Neuroscience Via Cherasco 15 10126 Turin ItalyCristina Moglia, University of Torino Section of Neurology, Department of Neuroscience Via Cherasco 15 10126 Turin ItalyRoberto Mutani, University of Torino Section of Neurology, Department of Neuroscience Via Cherasco 15 10126 Turin ItalyAdriano Chiò, University of Torino Section of Neurology, Department of Neuros... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3032237 Tue, 24 Nov 2009 07:10:26 +0100 3032237 http://www.medworm.com/index.php?rid=3020840&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0x7x6262t1767u33%2F Abstract  Migraine is a common neurological disease in the population and the most associated headache with mood disorder. Although the relationship between migraine and depression is well known, the reverse correlation between depression and migraine was observed but not well understood. The tight relationship between the two disturbances is also suggested by the efficacy of antidepressants for migraine treatment. Starting from these observations, we can presume that both migraine and depression have overlapping biological bases. The main target of antidepressant treatments belonging to the serotonin selective reuptake inhibitors (SSRI) type is the serotonin transporter (SERT); a well-studied polymorphic variant, in the promoter region of the gene (SERTPR), has been demons... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3020840 Sat, 21 Nov 2009 08:30:51 +0100 3020840 http://www.medworm.com/index.php?rid=3020839&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F888213g0w6066m15%2F Abstract  A 41-year-old man with multiple sclerosis (MS) complained of nocturnal enuresis at the third exacerbation. Neurological examination revealed echopraxia, forced grasp reflexes and palmo-mental reflexes. The urodynamic studies showed neither spinal cord nor peripheral nerve involvements. His brain magnetic resonance images (MRIs) revealed new lesions at the bilateral medial frontal lobes. The intravenous methylprednisolone therapy improved nocturnal enuresis and made brain MRI lesions smaller and gone. In addition to frequently observed spinal cord lesions, we should consider some medial frontal lesions to be responsible for micturitional disturbance in patients with MS. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0189-5Authors Sachiko... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3020839 Sat, 21 Nov 2009 08:30:51 +0100 3020839 http://www.medworm.com/index.php?rid=3020841&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp35332hu7n154145%2F Abstract  Social support and self-efficacy, that was defined as one’s belief in one’s capabilities to enact a certain behaviour, have a mediating effect on health outcomes and, by facilitating healthy behaviours and compliance to treatment, reduce morbidity and mortality. This pilot study aims to test whether social support and self-efficacy have a positive effect in improving health outcomes of patients with Myasthenia Gravis. 74 patients (mean age 48.1; 67.6% female) were enrolled and reported low self-efficacy and health status, but good perceived social support. Men reported better self-efficacy than women, and those living with a partner reported higher social support levels. No differences were found stratifying for disease onset, disease stage and patients’ wor... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3020841 Sat, 21 Nov 2009 08:30:50 +0100 3020841 http://www.medworm.com/index.php?rid=3020842&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx2240x7310886846%2F We report on a case of paradoxical embolism across a subclavian arterial–venous fistula. This case underlines the necessity of performing the ceTCD, as in this condition the right to left shunt could be detected by means of ceTCD, whereas the TEE reveals regular findings. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0185-9Authors Piergiorgio Lochner, University Hospital Giessen Department of Neurology Am Steg 14 35392 Giessen GermanyFrediano Tezzon, Franz Tappeiner Hospital Department of Neurology Meran ItalyRafaelle Nardone, Franz Tappeiner Hospital Department of Neurology Meran ItalyChristian Tanislav, University Hospital Giessen Department of Neurology Am Steg 14 35392 Giessen Germany Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3020842 Sat, 21 Nov 2009 08:30:49 +0100 3020842 http://www.medworm.com/index.php?rid=3020843&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fe12275g51328m624%2F Abstract  The aim of our pilot study was to investigate, by a proteomic approach, the expressed differences in cerebrospinal fluid (CSF) protein patterns in order to aid in the diagnosis and treatment of normal pressure hydrocephalus (NPH). Seventeen patients with NPH, selected by Intracranial-Pressure monitoring (ICPmo), underwent implantation of a shunt and after 6 months were clinically re-evaluated. Thirteen patients improved, whereas four did not. During ICPmo CSF was collected and its proteoma was analyzed by 2D gel electrophoresis and mass spectrometry. The over-expression of α2HS glycoprotein, α1 antichimotrypsin and α1beta glycoprotein and the under-expression of glial fibrillary acidic protein, apolipoproteins (AIV, J and E), complement C3c, anti-thrombin, α2 ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3020843 Sat, 21 Nov 2009 08:30:48 +0100 3020843 http://www.medworm.com/index.php?rid=3016358&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxxg8117621676kl7%2F Abstract  Previous reports have suggested an increased risk of psoriasis in MS patients. Worsening of dermatologic lesions during interferon therapy has been rarely reported, but activation of psoriatic arthritis has not been described until now. The following is a case report. A 37-year-old woman affected by relapsing–remitting multiple sclerosis had severe worsening of cutaneous psoriasis and activation of psoriatic arthritis during interferon beta treatment. The symptoms resolved after therapy discontinuation. This case further supports that activation of psoriasis might be a rare side effect of IFNB therapy and suggests careful evaluation of concomitant morbidity to allow a patient-oriented treatment strategy. Content Type Journal ArticleCategory Case ReportDOI 10.1... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3016358 Thu, 19 Nov 2009 07:47:32 +0100 3016358 http://www.medworm.com/index.php?rid=3016359&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn514h6846w262h13%2F Abstract  It has recently been shown that GAB2 alleles modify the risk for late-onset Alzheimer disease (LOAD) in apolipoprotein E (ApoE)ε4 allele carriers in a genome-wide association study. Some studies subsequently in Caucasians population, though not all, have demonstrated that GAB2 polymorphisms might be associated with LOAD susceptibility. The aim of this study is to evaluate the reported polymorphisms (rs2373115 and rs1385600) and GAB2 haplotypes (rs2373115–rs1385600) for an interaction with the ApoEε4 allele in a cohort of Chinese LOAD. We conducted a case–control study in 292 LOAD and 227 non-demented controls from the Chinese Han population. Our study does not find any association between the two tested SNPs and GAB2 haplotypes and LOAD or any synergetic int... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3016359 Thu, 19 Nov 2009 07:47:15 +0100 3016359 http://www.medworm.com/index.php?rid=3016360&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F6743301677w05h25%2F Abstract  Population ageing and improved healthcare may lead to an increase in the prevalence of stroke. The aim of this study is to investigate the prevalence of stroke and stroke-related disability in a population sample resident in Aosta, Italy. The information was collect using a simple questionnaire for first ever stroke in the past combined with the analysis of the patients’ medical records and integrated with the information reported by six general practitioners. 102 cases of stroke were identified in the study population of 6,930 subjects, for an overall prevalence per 1,000 inhabitants of 1.4 (95% CI 0.81–1.99), which increased to 4.79 (95% CI 3.29–6.29) in subjects aged ≥65 years. Fifty-nine percent of the cases were completely or partially dependent ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3016360 Thu, 19 Nov 2009 07:47:13 +0100 3016360 http://www.medworm.com/index.php?rid=3016361&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fvh68jg5133m78r43%2F We report a case of a man who acutely presented confusion and cortical blindness. The cerebral angiography demonstrated bilateral occlusion of posterior cerebral artery (PCA). Sequential intravenous (IV) and intra-arterial (IA) thrombolysis were ineffective and the patient developed a complete Dide–Botcazo syndrome. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0179-7Authors Manuel Cappellari, Azienda Ospedaliera-Universitaria Dipartimento di Scienze Neurologiche e della Visione Verona ItalyGiampaolo Tomelleri, Azienda Ospedaliera-Universitaria Unità Operativa di Neurologia Verona ItalyAlessandro Di Matteo, Azienda Ospedaliera-Universitaria Dipartimento di Scienze Neurologiche e della Visione Verona ItalyMonica Carletti, Azienda Ospedaliera-Universitaria ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3016361 Thu, 19 Nov 2009 07:47:10 +0100 3016361 http://www.medworm.com/index.php?rid=3016364&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu485t566v4pr8144%2F Abstract  Diabetic mellitus (DM) has many well-known complications. However, there is one rare complication, diabetic muscle infarction (DMI), which is usually under diagnosed. Hereby, we present a 53-year-old Chinese man with a history of DM, hypertension and atrial fibrillation. He had acute onset of severe left lower leg pain and swelling with difficulty in walking 4 days before admission. Physical examination revealed non-pitting and non-erythematous swelling with cold sensation of the left medial calf muscles. Magnetic resonance image (MRI) showed homogenous high signal changes in the calf muscles on T2 images, which indicated DMI. After anticoagulation treatment, the patient had a fair recovery within 4 weeks and he could walk by himself thereafter. DMI is a... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3016364 Thu, 19 Nov 2009 07:47:09 +0100 3016364 http://www.medworm.com/index.php?rid=3016363&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fug383g394u290023%2F Abstract  The Fattori di Rischio Ambientali e Genetici Associati alla Malattia di Parkinson (FRAGAMP) study is a multicenter case–control study carried out to evaluate the possible role of environmental and genetic factors in Parkinson’s disease (PD). Cases and controls were enrolled from five Movement Disorder centers in Central-Southern Italy. PD was diagnosed according to Gelb’s criteria while the control groups consisted of the spouses of the enrolled patients or of healthy controls matched by age and area of residence. Cases and controls underwent a standardised questionnaire and a blood sample was taken for molecular analyses. At the end of the study 585 cases and 481 control subjects (287 spouse-controls and 194 generic-controls) were enrolled. Patients had a H... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3016363 Thu, 19 Nov 2009 07:47:09 +0100 3016363 http://www.medworm.com/index.php?rid=3016362&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F46gg34379646u6k2%2F The objective of this study is to evaluate pursuit ocular movements (POM) by using a vision-based non-intrusive eye tracker, in patients with suspected Parkinson’s disease (PD), before and after l-Dopa administration. We studied ten patients with suspected diagnosis of idiopathic PD. We compared POM values to those of a group of normal controls (NC), and evaluated them before and after l-Dopa administration. Unified Parkinson’s Disease Rating Scale (UPDRS) motor subscores improved significantly (p = 0.001). At baseline, values of POM were lower in suspected PD patients than in NC (p = 0.01). One hour after l-Dopa administration, POM values correlated with UPDRS motor subscore (p = 0.01). We used a recent method, a new vision-based non-intrusive eye track... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3016362 Thu, 19 Nov 2009 07:47:09 +0100 3016362 http://www.medworm.com/index.php?rid=2986984&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp33444m251513364%2F Abstract  Tests of famous faces are used to study language and memory. Yet, the effect of stimulus properties on performance has not been fully investigated. To identify factors influencing proper name retrieval and to probe stimulus-specific parameters within proper name lexicon, we analysed the results obtained by 300 healthy participants on a test of famous faces that includes 74 personalities. A factor analysis yielded five main factors that were characterized by language (national or foreign names), epoch of peak popularity (current, recent or past) and occupation (politicians, entertainment and sports) of the personalities. Multiple regression analysis showed that participants’ education, age and gender accounted for 10–32% of the variance in factor scores. These ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2986984 Wed, 11 Nov 2009 06:57:11 +0100 2986984 http://www.medworm.com/index.php?rid=2982996&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F08623067h0x75x25%2F We report on four new HI patients presenting with heterogeneous seizure manifestations and we review the literature concerning epileptic seizures in HI. At one extreme, there are patients with generalized seizures well controlled by drug treatment, whereas at the opposite there are patients with severe, often pharmacoresistant, focal seizures. The genetic substrate for HI syndrome is not homogenous and only partially understood. Further researches are required to shed light on the pathogenesis of HI phenotypes. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s10072-009-0160-5Authors Komi Assogba, Centre Saint-Paul, Hôpital Henri Gastaut Marseille FranceEdoardo Ferlazzo, IRCCS Centro Neurolesi “Bonino Pulejo” Messina ItalyPasquale Striano, University of Genoa Mu... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2982996 Tue, 10 Nov 2009 08:08:58 +0100 2982996 http://www.medworm.com/index.php?rid=2971562&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp72x6156241pp580%2F We describe a clinical case of neuroborreliosis that occurred in the absence of classical erythema migrans or arthralgia. Magnetic resonance imaging findings compatible with simil-vasculitis and demyelinating lesions associated with the presence of anti-B. burgdorferi antibodies in the plasma or cerebrospinal liquid is an indication for antimicrobial treatment against B. burgdorferi. An early diagnosis and a prompt establishment of an adequate antibiotic treatment is needed for a successful recovery. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0175-yAuthors Iolanda Santino, Sapienza University of Rome Department of Public Health Sciences P.le Aldo Moro, 5 00185 Rome ItalyPaola Comite, Sapienza University of Rome Department of Experimental Medicine and Path... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2971562 Fri, 06 Nov 2009 06:47:59 +0100 2971562 http://www.medworm.com/index.php?rid=2961216&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft274u7824n32t621%2F Abstract  The results on relapse rate and disease progression of available drugs for multiple sclerosis are shown, as well as their most relevant side effects. Results from pivotal and long-term follw-up studies support the efficacy and safety of intererons and glatiramer acetate. The treatment with mitoxantrone is limited by the occurrence of infertility, cardiotoxicy and leukaemia. Efficacy and tolerability of natalizumab are undisputable, compared to other drugs. Risks related to its treatment are PML, opportunistic infections, hepatotoxicity, melanoma, and their occurrence needs to be more exactly assessed by post-marketing surveillance. The principles of induction versus escalating therapy are also discussed. The final therapeutic decision is based on the evaluation of... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2961216 Tue, 03 Nov 2009 02:11:42 +0100 2961216 http://www.medworm.com/index.php?rid=2961217&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj23t7331x0120852%2F Abstract  Autologous haematopoietic stem-cell transplantation has been evaluated over the last years as a possible new therapeutic strategy in severe forms of multiple sclerosis unresponsive to the approved therapies. Up to now, more than 400 patients have been treated and numerous are the phase I and phase II studies which addressed the feasibility of this treatment, the efficacy, side effects and transplant-related mortality. The clinical response is strongly related to the intensity of the conditioning regimen utilized as well as to the phase of the disease course in which the therapy is carried out. Rapidly evolving multiple sclerosis with a relapsing–remitting clinical course and MRI signs of activity are the cases that can take more advantage. The risk of mortality,... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2961217 Tue, 03 Nov 2009 02:11:32 +0100 2961217 http://www.medworm.com/index.php?rid=2961218&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fa5l657n870068090%2F Abstract  Mitoxantrone (MTX) is a synthetic antineoplastic cytotoxic drug, active both on proliferative and non-proliferative cells. The efficacy of MTX has been suggested by many open-label or observational studies and demonstrated in four randomized controlled clinical trials (RCTs). It is indicated for reducing neurological disability and the frequency of clinical relapses in patients with progressive relapsing and worsening relapsing–remitting MS patients. The short-term most frequent adverse events observed in RCTs have been nausea/vomiting, alopecia, an increased risk of urinary and respiratory tract infections, phlebitis, transitory leukopenia, amenorrhea in female patients and infertility. However, the most serious risks of the drug are represented by potential ca... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2961218 Tue, 03 Nov 2009 02:11:23 +0100 2961218 http://www.medworm.com/index.php?rid=2961219&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F20315887440231k6%2F Abstract  Therapeutic monoclonal antibodies are potent new tools for a molecular targeted approach to modify the course of multiple sclerosis (MS). Natalizumab is a monoclonal antibody targeted against alpha-4 integrin that has proved to be very effective in the treatment of MS. It is well tolerated, although severe side effects have been reported that have conditioned its use as a second-line drug for the treatment of MS. The clinical benefit of natalizumab should be weighed carefully against the potential risk of serious adverse events. Therefore, risk management plans have already been developed in order to prevent or minimise risks relating to natalizumab. Data so far obtained from these observational programs confirm the already demonstrated risk-benefit profile of nat... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2961219 Tue, 03 Nov 2009 02:11:13 +0100 2961219 http://www.medworm.com/index.php?rid=2961220&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr21686723h987156%2F Abstract  Cyclophosphamide (Cy) is an alkylating agent used over the past 40 years to halt rapidly progressive forms of multiple sclerosis (MS). High doses of Cy produce marked immunosuppression and an anti-inflammatory immune deviation. Cy is most effective in young patients, with very active MS (frequent relapses, rapid accumulation of disability, and gad+ lesions on brain MRI). Monthly intravenous pulses of Cy for 1 year, followed by bimonthly pulses for the second year are a well-tolerated protocol in MS. Most side effects (mild alopecia, nausea and vomiting, and cystitis) are transient, dose dependent, and reversible. Permanent amenorrhoea and bladder cancer have rarely been described. As second-line therapy, Cy can be used in non-responders to IFN-β or glat... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2961220 Tue, 03 Nov 2009 02:11:04 +0100 2961220 http://www.medworm.com/index.php?rid=2961221&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh741712338047161%2F Abstract  Disease-modifying treatments are now available in relapsing–remitting and secondary progressive multiple sclerosis (MS), and their beneficial effects have been shown in several clinical studies. However, as these treatments are only partially effective in halting the MS disease process and are frequently associated with side effects and suboptimal patient adherence, new oral therapeutic approaches are warranted. This review focuses on advances in current and novel oral treatment approaches for MS. Several pivotal reports have provided promising results for new oral therapies evaluating the safety and efficacy of new agents including fingolimod, fumaric acid, cladribine, teriflunomide and laquinimod. Content Type Journal ArticleCategory MS TreatmentDOI 10.1007/... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2961221 Tue, 03 Nov 2009 02:10:54 +0100 2961221 http://www.medworm.com/index.php?rid=3098450&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F98v05q2wm3u114qg%2F Abstract  At the end of 2006 a country-based surveillance program on natalizumab therapy in multiple sclerosis was settled in Italy by a collaborative effort of the Italian Drug Agency (AIFA) and a group of experts and neurologists appointed by the National Society of Neurology (SIN). After 2 years, 1,818 patients are registered in the database. The majority of cases (88.6%) failed the therapy with beta interferon or glatiramer acetate and had relapses or accumulated disability during immunomodulating treatment, while 11.4% of patients enrolled in the surveillance study were not previously treated with immunomodulating therapies and had a rapidly evolving clinical course. Almost 10% of the patients treated with natalizumab interrupted, for various different reasons, th... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=3098450 Tue, 03 Nov 2009 02:10:45 +0100 3098450 http://www.medworm.com/index.php?rid=2961222&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F98v05q2wm3u114qg%2F Abstract  At the end of 2006 a country-based surveillance program on natalizumab therapy in multiple sclerosis was settled in Italy by a collaborative effort of the Italian Drug Agency (AIFA) and a group of experts and neurologists appointed by the National Society of Neurology (SIN). After 2 years, 1,818 patients are registered in the database. The majority of cases (88.6%) failed the therapy with beta interferon or glatiramer acetate and had relapses or accumulated disability during immunomodulating treatment, while 11.4% of patients enrolled in the surveillance study were not previously treated with immunomodulating therapies and had a rapidly evolving clinical course. Almost 10% of the patients treated with natalizumab interrupted, for various different reasons, th... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2961222 Tue, 03 Nov 2009 02:10:45 +0100 2961222 http://www.medworm.com/index.php?rid=2947979&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fj5mvv2hr62620647%2F Abstract  We investigated the association of specific polymorphisms of the interleukin IL-1b (AvaI −511 and TaqI +3,953) and IL-1 receptor antagonist (IL-1RN) (a variable number of tandem repeats; VNTR) genes with both the susceptibility to and the clinical characteristics in Greek multiple sclerosis (MS) patients cohort with bout-onset. Genotypes were determined from 351 patients with clinically definite MS and 375 age- and sex-matched healthy controls. Our results showed no significant differences in the distribution of these polymorphisms between MS patients and controls. Furthermore, stratification for clinical characteristics, such as age at disease onset, clinical course, sex, and severity did not provide significant differences between patients and controls. Togethe... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2947979 Fri, 30 Oct 2009 07:48:23 +0100 2947979 http://www.medworm.com/index.php?rid=2947981&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh1nn958075787qg6%2F The objective of the study was to investigate the phonatory function in MS patients using objective measures. The speech of 64 MS patients and 64 pair-matched controls was recorded and analyzed using electroglottography, a physiological method that measures the electrical conductance during the opening and closing phases of the vibrating vocal folds. Electroglottographic parameters were correlated with clinical and MRI features. Most of the variables that have been used for the analysis of voice (vocal jitter P = 0.041, standard deviation of the average fundamental frequency P = 0.018, and the mean fundamental frequency of the vibrating vocal folds P = 0.025) differentiated the MS group from the control group. Phonatory function is impaired in MS patients,... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2947981 Fri, 30 Oct 2009 07:48:22 +0100 2947981 http://www.medworm.com/index.php?rid=2947980&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F27638p2800526t7p%2F We report clinical, radiological and pathological findings in a patient with central pontine and extrapontine myelinolysis. The patient was a 61-year-old woman who had a radical mastectomy for breast cancer. Based on clinical evidence, acute hyponatremia had set in only a few days before onset of symptoms. The patient’s disease progressed in two stages and became more severe during slow hyponatremia correction after 9 days from onset. Diffusion MRI provided early evidence of neurological lesions. In spite of a therapeutic attempt, the patient died unexpectedly 18 days after onset of her neurological disease due to massive pulmonary embolism. Histologically, our findings confirmed that the major features of central pontine myelinolysis in the acute stage are demyelination,... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2947980 Fri, 30 Oct 2009 07:48:22 +0100 2947980 http://www.medworm.com/index.php?rid=2947982&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9284001867224048%2F Abstract  Platypnea–orthodeoxia is a syndrome characterized by dyspnea and hypoxemia in orthostatism relieved by supine position. This phenomenon is frequently associated with interatrial communication, mainly patent foramen ovale. The association of platypnea–orthodeoxia syndrome with recurrent stroke and patent foramen ovale is extremely uncommon. A 73-year-old woman experienced recurrent attacks of dyspnea after an ischemic stroke. Arterial blood gas analysis changes in upright and supine position confirmed the diagnosis of platypnea–orthodeoxia syndrome. Contrast-enhanced transthoracic echocardiography showed patent foramen ovale with atrial septal aneurysm and right-to-left shunt. Percutaneous closure of patent foramen ovale led to stabilization of blood oxygen s... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2947982 Fri, 30 Oct 2009 07:48:21 +0100 2947982 http://www.medworm.com/index.php?rid=2947983&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq5h85t5453v4135t%2F This report describes a case of a cystic neurohypophysial germinoma associated with moyamoya disease. A 15-year-old girl with central diabetes insipidus was admitted to the hospital. Radiological examination revealed a suprasellar tumor and moyamoya disease. Surgery and pathological study confirmed pure germinoma. After the patient was treated with radiation and chemotherapy, the tumor was controlled without any effect on the moyamoya vessels. This report describes a rare incidental combination of moyamoya disease and a suprasellar germinoma. In the management of such cases, physicians should be aware of the symptoms, course, and natural history of both diseases and the effects and side effects of each type of therapy. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s1... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2947983 Fri, 30 Oct 2009 07:48:20 +0100 2947983 http://www.medworm.com/index.php?rid=2936699&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn034540175413156%2F Abstract  Choreoathetotic syndromes are frequently observed in children after congenital cardiopathy surgery. To report the case of an adult patient who developed a choreoathetotic syndrome after cardiac operation, probably related to a transitory hypometabolism of basal ganglia. A 52-year-old patient underwent heart surgery under circulatory arrest and deep hypothermia, for type III dissecting thoracic aorta aneurysm. Two weeks later she developed an acute choreic syndrome. The positron emission tomography using fluorodeoxyglucose (FDGC-PET) showed a bilateral hypometabolism of basal ganglia. After haloperidol administration, choreic syndrome improved and 6 months later FDGC-PET was normal. Choreoathetosis has been described as a rare complication after heart surgery.... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2936699 Tue, 27 Oct 2009 18:23:05 +0100 2936699 http://www.medworm.com/index.php?rid=2906645&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fpp41348451tkt656%2F Abstract  Infarction in the genu of the internal capsule causes dementia that is characterized by abulia, lethargy and memory loss without obvious motor palsy (capsular genu syndrome). We found infarction or decreased cerebral blood flow in the genu of the internal capsule in 6 of 13 patients with severe bacterial meningitis. Four of these six patients developed post-meningitis dementia, characterized by abulia, lethargy, and memory loss. Of 24 patients with viral meningitis, none developed capsular genu ischemia or post-meningitis dementia. In patients with severe bacterial meningitis, capsular genu ischemia may play some role in the development of post-meningitis dementia. In patients with viral meningitis, absence of such ischemia may explain, at least in a part, the rar... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2906645 Fri, 16 Oct 2009 17:56:45 +0100 2906645 http://www.medworm.com/index.php?rid=2906646&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx3v53k896261w427%2F Abstract  The personal diary of Sir Augustus d’Esté, born 1794 grandson of King George III of England, reveals a medical history strongly suggesting that Augustus suffered from multiple sclerosis (MS). It could well be the first record of a person having this disease. Charcot coined the term sclérose en plaques 20 years after the death of this patient in 1848. The onset of this man’s MS seems to have been in 1822 with bilateral optic neuritis, the disease gradually developing in the classic manner with bouts derived from different loci in the central nervous system and eventually a secondary progressive form with paraparesis, sphincter incontinence, urinary problems and impotence. In 1941, Firth highlighted the case of Augustus d’Esté and later wrote a descript... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2906646 Fri, 16 Oct 2009 17:56:44 +0100 2906646 http://www.medworm.com/index.php?rid=2906647&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn8237741u9708174%2F Abstract  Recent studies suggest strong interactions between cerebrovascular and Alzheimer’s disease (AD) pathology. These conditions share common risk factors and individuals having both frequently show greater cognitive impairment than those affected by only one disease. Many studies point to early vascular dysregulations in AD. The exchange between vascular and neural cells occurs through mechanisms not completely understood, involving interactions among endothelial, glial, neuronal and smooth muscle cells within the neurovascular unit. Studies suggest that the dysregulation of the unit is likely associated with hypertension and other systemic diseases. Associations between hypertension and cognitive decline are not established, but other variables associated with hype... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2906647 Fri, 16 Oct 2009 17:56:43 +0100 2906647 http://www.medworm.com/index.php?rid=2906648&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd40n6517384850r7%2F Abstract  We prospectively followed-up 32 pediatric patients with cerebral cavernomas (CCs) to better define surgical indications in this population. Three groups of patients were identified: (a) children with macrohemorrhage (21 patients, 65.6%), (b) children with localized or diffuse headache (6 patients, 18.8%) and (c) children with epilepsy (5 patients, 15.6%). Surgery was performed in 28 out of the 32 (87.5%) subjects. New transient post-operative neurological deficits were observed in two children. One child developed a post-operative hematoma. At a median follow-up of 4 years (range 1–11 years), 22 out of the 28 (78.6%) operated patients were in good conditions. All operated subjects with epilepsy were seizure-free. We confirm the high risk of macrohemorrh... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2906648 Fri, 16 Oct 2009 09:21:02 +0100 2906648 http://www.medworm.com/index.php?rid=2880598&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fbl2k60k674387378%2F In conclusion, the utilization of thrombolytic therapy is low and complication rate is high. Interventions for training physicians are needed. Content Type Journal ArticleCategory Brief CommunicationDOI 10.1007/s10072-009-0159-yAuthors Mohammad Wasay, Aga Khan University Department of Neurology and Medicine Stadium Road Karachi 74800 PakistanHazim Barohi, Aga Khan University Department of Neurology and Medicine Stadium Road Karachi 74800 PakistanAbdul Malik, Liaquat National Hospital Department of Neurology Karachi PakistanAdnan Yousuf, Aga Khan University Department of Neurology and Medicine Stadium Road Karachi 74800 PakistanSafia Awan, Aga Khan University Department of Neurology and Medicine Stadium Road Karachi 74800 PakistanAyeesha K. Kamal, Aga Khan University Department of Neu... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2880598 Fri, 09 Oct 2009 06:16:54 +0100 2880598 http://www.medworm.com/index.php?rid=2880599&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F37256982346711r7%2F Abstract  Aim of this study is to verify whether there is concordance between disease’s severity, health-related quality of life (HRQoL) and disability in patients with Myasthenia gravis (MG). 102 MG patients were clustered on the basis of HRQoL and disability scores into three groups: low disability and low HRQoL decrement (51 patients), intermediate disability and HRQoL decrement (28 patients), severe disability and high HRQoL decrement (23 patients). Cross tabulation with symmetric measures (Cramer’s V and Contingency Coefficient) was used to verify the relationships between disease severity groups, based on the Myasthenia Gravis Foundation of America (MGFA) criteria, and obtained clusters. Results confirm a significant relationship between MG severity groups, HR... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2880599 Fri, 09 Oct 2009 06:16:53 +0100 2880599 http://www.medworm.com/index.php?rid=2877913&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F1724v58572621534%2F Abstract  The role of hypertension in the late onset of hemifacial spasm (HFS) is evaluated in a family, spanning four generations. Magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) revealed a variable anatomical relationship between nervous and vascular structures in the symptomatic cerebello-pontine angle. In one case, showing neurovascular conflict (NVC), microvascular surgical decompression was followed by clinical resolution of HFS. Neuroimaging suggesting NVC was found in all symptomatic patients of the last two generations and in three younger subjects not affected by HFS. As a determinant for the late development of clinical expression is reviewed the role of arterial hypertension, detected few years before HFS appearing in all symptomatic su... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2877913 Thu, 08 Oct 2009 07:01:34 +0100 2877913 http://www.medworm.com/index.php?rid=2877912&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F968u224442h61272%2F Abstract  Leprosy (Hansen’s disease) is a chronic granulomatous infectious disease, caused by Mycobacterium leprae, with cutaneous and neurological manifestations. Leprosy is very rare in Europe but some cases are reported, especially among people coming from endemic areas. Here, we report a case of Hansen’s disease and emphasize the importance of a prompt diagnosis and treatment also in non-endemic areas. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0152-5Authors Paolo Aridon, University of Palermo Dipartimento Universitario di Neuroscienze Cliniche (DiNeC) Via Gaetano La Loggia 1 90129 Palermo ItalyPaolo Ragonese, University of Palermo Dipartimento Universitario di Neuroscienze Cliniche (DiNeC) Via Gaetano La Loggia 1 90129 Palermo ItalyMari... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2877912 Thu, 08 Oct 2009 07:01:34 +0100 2877912 http://www.medworm.com/index.php?rid=2873922&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fv674mmv11n3n6h0k%2F We presented nine patients with RPLS who had primary diagnoses such as acute post-streptococcal glomerulonephritis, idiopathic hypertension, the performing of intravenous immunoglobulin for infection with crescentic glomerulonephritis, erythrocyte transfusion for severe iron deficiency, l-asparaginase treatment for acute lymphoblastic leukemia and performing of granulocyte-colony stimulating factor for ulcerative colitis due to neutropenia. Early recognition of RPLS as complication during different diseases and therapy in childhood may facilitate precise diagnosis and appropriate treatment. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-009-0158-zAuthors Hakan Gümüş, Kayseri Education and Research Hospital Department of Pediatric Neurology Talas Kayseri... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2873922 Wed, 07 Oct 2009 07:40:31 +0100 2873922 http://www.medworm.com/index.php?rid=2870444&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F2564125614267w55%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10072-009-0166-zAuthors Yasuo Miki, Aomori Prefectural Central Hospital Department of Neurology Higashi Tsukurimichi 2-1-1 Aomori JapanMasahiko Tomiyama, Aomori Prefectural Central Hospital Department of Neurology Higashi Tsukurimichi 2-1-1 Aomori JapanAkira Arai, Aomori Prefectural Central Hospital Department of Neurology Higashi Tsukurimichi 2-1-1 Aomori JapanTamaki Kimura, Aomori Prefectural Central Hospital Department of Neurology Higashi Tsukurimichi 2-1-1 Aomori JapanChieko Suzuki, Aomori Prefectural Central Hospital Department of Neurology Higashi Tsukurimichi 2-1-1 Aomori JapanJin-ichi Nunomura, Aomori Prefectural Central Hospital Department of Neurology Higashi Tsukurimichi 2-1-1 Aomori JapanHiroshi Midorika... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2870444 Tue, 06 Oct 2009 12:53:16 +0100 2870444 http://www.medworm.com/index.php?rid=2870446&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F16335746x0841858%2F Abstract  The frequency of psychopathological symptoms in patients with Parkinson’s disease (PD) is often underestimated because of the lack of comprehensive evaluation tools. A total of 486 consecutive non-demented PD patients completed the Symptom Checklist 90 Revised (SCL-90R) self-reported questionnaire, a validated tool for the assessment of psychopathological symptoms on nine dimensions. Somatization, depression, anxiety and obsessive–compulsive behaviors were reported by nearly half of the PD patients. They were more likely to occur in females. Disease-related factors such as duration, severity and daily dosages, but not type of dopaminergic medications, were associated with the occurrence of these symptoms. Psychopathological features are frequent in PD and thei... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2870446 Tue, 06 Oct 2009 12:53:15 +0100 2870446 http://www.medworm.com/index.php?rid=2870445&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F9277n255j28j1232%2F Abstract  The administration of analgesics to the thoracic spine is established practice in the operating room, minimizing the need for systemic anaesthetic administration during thoracic surgery. Complications arising from thoracic epidural anaesthesia are uncommon but potentially disastrous. Here, we report the case of a 43-year-old woman who developed a thoracic epidural haematoma with paraplegia a few hours after the removal of an epidural catheter. The patient underwent emergency thoracic laminectomy and clot evacuation. After a 4 months period, there was almost complete neurological recovery. Epidural haematoma is a rare complication that must be heeded and urgently treated in case of clinical deterioration after the epidural analgesia. Content Type Journal Art... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2870445 Tue, 06 Oct 2009 12:53:15 +0100 2870445 http://www.medworm.com/index.php?rid=2870447&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fg544v354155x368r%2F In conclusions, left insular cortex lesions should be considered in the differential diagnosis of isolated truncal ataxia. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0164-1Authors Li-Min Liou, Kaohsiung Medical University Department of Neurology, Kaohsiung Municipal Hsiao-kang Hospital Kaohsiung TaiwanYuh-Cherng Guo, Kaohsiung Medical University Department of Neurology, Kaohsiung Municipal Hsiao-kang Hospital Kaohsiung TaiwanChiou-Lian Lai, Kaohsiung Medical University Department of and Master’s Program in Neurology, Faculty of Medicine, College of Medicine Kaohsiung TaiwanChin-Ling Tsai, Kaohsiung Medical University Department of Neurology, Kaohsiung Municipal Hsiao-kang Hospital Kaohsiung TaiwanGim-Thean Khor, Kaohsiung Medical University Department of... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2870447 Tue, 06 Oct 2009 12:53:13 +0100 2870447 http://www.medworm.com/index.php?rid=2870449&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff333780577755561%2F We report a patient with history of ovarian carcinoma that presented with ptosis, diplopia and gait ataxia. Neurophysiological examination and laboratory tests revealed the presence of MG and PCD. An integrated FDG-PET/contrast-enhanced CT scan showed tumor recurrence. This is to the best of our knowledge the first association of MG and PCD with recurring ovarian carcinoma. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0154-3Authors Pietro Caliandro, Università Cattolica del Sacro Cuore Neurology Department, Istituto di Neurologia Pol. “A: Gemelli” Largo Gemelli 8 00168 Rome ItalyMarco Luigetti, Università Cattolica del Sacro Cuore Neurology Department, Istituto di Neurologia Pol. “A: Gemelli” Largo Gemelli 8 00168 Rome ItalyEnzo Ricci, Università... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2870449 Tue, 06 Oct 2009 12:53:11 +0100 2870449 http://www.medworm.com/index.php?rid=2870448&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fyk775422956178j4%2F Abstract  Due to the alleged higher risk of complications of microvascular decompression for trigeminal neuralgia in elderly we evaluated its age-related results. A retrospective analysis of clinical outcome and complications was performed in 476 patients affected by drug-resistant trigeminal neuralgia who underwent microvascular decompression. As much as 117 patients older than 65 years (Group 1) and 359 under the age of 65 (Group 2) were followed-up for a period of 7–138 months. Pain relief was complete without medication in 84.5% in Group 1. Morbidity included slight trigeminal hypoesthesia in 5.8%; severe hearing loss in 0.9%; CSF leakage in 4.2%; transient diplopia in 3.4%; and posterior fossa subdural hematoma in 0.8% of these patients. Mortality was null.... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2870448 Tue, 06 Oct 2009 12:53:11 +0100 2870448 http://www.medworm.com/index.php?rid=2870450&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F78l5736871muupj4%2F We report a 19-year-old man with BD who presented with cranial polyneuropathy secondary to aseptic meningitis. He made a gradual though incomplete recovery with steroid therapy. Cranial polyneuropathy secondary to meningeal involvement can be a presentation of n-BD, and Behcet’s disease should be a consideration in patients with idiopathic cranial polyneuropathy. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0162-3Authors Ali Alrefai, Jordan University of Science and Technology (JUST) Department of Neuroscience PO Box 3030 Irbid 22110 JordanKhalid El-Salem, Jordan University of Science and Technology (JUST) Department of Neuroscience PO Box 3030 Irbid 22110 JordanRuba Saadeh, Jordan University of Science and Technology (JUST) Department of Neuroscience PO... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2870450 Tue, 06 Oct 2009 12:53:10 +0100 2870450 http://www.medworm.com/index.php?rid=2840616&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr3047k1113436g11%2F This study indicates that there is dissociation between stopping status epilepticus and modifying its long-term consequences. Content Type Journal ArticleCategory Brief CommunicationDOI 10.1007/s10072-009-0115-xAuthors Henry Hasson, Albert Einstein College of Medicine of Yeshiva University Saul R. Korey Department of Neurology Bronx NY USASamit Malhotra, SUNY Downstate Medical Center Department of Neurology Brooklyn NY USAFilippo S. Giorgi, University of Pisa Section of Neurology, Department of Neuroscience Pisa ItalyDaniel M. Rosenbaum, SUNY Downstate Medical Center Department of Neurology Brooklyn NY USASolomon L. Moshé, Albert Einstein College of Medicine of Yeshiva University Saul R. Korey Department of Neurology Bronx NY USA Journal Neurological SciencesOnline ISSN 1590-... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2840616 Fri, 25 Sep 2009 05:48:12 +0100 2840616 http://www.medworm.com/index.php?rid=2835167&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fh3180751r4260193%2F Abstract  Visual aura is the most common feature associated with migraine, though it can occur separately. In both cases it often represents a dramatic event, especially for patients who experience it for the first time. Besides, its subjective characteristics may illuminate on the functional architecture of the visual cortex. Repetitive events of migraine and visual aura have been suggested to affect the visual system in the long run, both on the cortical and precortical level. In effect, objective investigation of visual functions in patients support the idea that a selective damage does occur, so that more attention to visual examination seems to be justified. In this paper, subjective and psychophysical aspects of visual aura are examined, lastly highlighting and discus... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2835167 Fri, 25 Sep 2009 05:48:12 +0100 2835167 http://www.medworm.com/index.php?rid=2840617&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fq538633076602955%2F We report the clinical vignette of two patients manifesting an unusual presentation of primary blepharospasm, specifically triggered by voiced speech and associated with an otherwise ‘typical’ presentation of primary adult-onset dystonia in the lower face, larynx or upper limb. Speech-induced primary blepharospasm seems a rare occurrence, representing 1.3% of our clinic-based series of 149 patients with primary adult-onset primary blepharospasm. In these atypical patients, the feature of speech inducibility suggests that the abnormal surrounding inhibition between cortical subregions representing laryngeal and orbicularis oculi muscles might underlie dystonic overflow to the orbicularis oculi muscles following the voiced speech. Content Type Journal ArticleCategory Case Report... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2840617 Thu, 24 Sep 2009 16:45:42 +0100 2840617 http://www.medworm.com/index.php?rid=2840618&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy87h7904448221m4%2F We describe a 57-year-old man who underwent liver transplantation and was started on immunosuppressive therapy with tacrolimus (FK506). Six months later, he started complaining of a progressive motor and sensory impairment of the left side, together with cognitive impairment. Brain MRI showed an enlarging lesion of the white matter with peripheral contrast enhancement. PET study indicated severe hypometabolism in the right hemisphere and spectroscopic MRI showed a peak of choline and relative reduction of other metabolites. Findings of CSF examinations and cultures, serology, and molecular techniques were normal. Tacrolimus treatment was stopped. A cerebral biopsy of the lesion showed a sub acute necrotizing process. In the following months, cognitive status of the patient tende... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2840618 Thu, 24 Sep 2009 16:45:39 +0100 2840618 http://www.medworm.com/index.php?rid=2840619&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx588777778p26v77%2F Abstract  The dopamine transporter (DAT1) is a membrane spanning protein that binds the neurotransmitter dopamine and performs re-uptake of dopamine from the synapse into a neuron. The gene encoding DAT1 consists of 15 exons spanning 60 kb on chromosome 5p15.32. Several studies have investigated the possible associations between variants in DAT1 gene and psychiatric disorders. The present study aimed to determine the distribution of the variable number of tandem repeat (VNTR) polymorphism in the 3′ untranslated region of DAT1 in 12 Indian populations. A total of 471 healthy unrelated individuals in 12 Indian populations from 3 linguistic groups were included in the present study. The analysis was carried out using PCR and electrophoresis. Overall, 4 alleles of the DA... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2840619 Thu, 24 Sep 2009 16:45:38 +0100 2840619 http://www.medworm.com/index.php?rid=2833432&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F274641136328j8ul%2F In conclusion, CyberKnife radiosurgery appears to be both safe and effective in the treatment of skull base paragangliomas. Determining whether long-term complications will arise will require further investigation. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-009-0138-3Authors Livia C. Bianchi, CyberKnife Center CDI Milan ItalyMarcello Marchetti, Fondazione IRCCS Istituto Neurologico Carlo Besta Department of Neurosurgery, Division of Radiotherapy Milan ItalyLorenzo Brait, CyberKnife Center CDI Milan ItalyAchille Bergantin, CyberKnife Center CDI Milan ItalyIda Milanesi, Fondazione IRCCS Istituto Neurologico Carlo Besta Department of Neurosurgery, Division of Radiotherapy Milan ItalyGiovanni Broggi, Fondazione IRCCS Istituto Neurologico Carlo Besta Departme... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2833432 Wed, 23 Sep 2009 06:04:10 +0100 2833432 http://www.medworm.com/index.php?rid=2816878&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fd0742175wh37n420%2F Abstract  The spinocerebellar ataxias (SCAs) are a clinically and genetically heterogeneous group of neurodegenerative diseases. Researchers have recently found that SCA type 11 (SCA11) is associated with mutations in the TTBK2 gene. In our previous work, we performed mutation detection in SCA1, 2, 3, 6, 7, 8, 10, 12, 17 and dentatorubral-pallidoluysian atrophy gene in Chinese SCA patients, but the genes responsible for approximately 40% of our patients have not yet been identified. To investigate the frequency of SCA11 in Chinese SCA patients, we examined the TTBK2 gene in 68 unrelated probands diagnosed with dominantly inherited ataxia using the denaturing high-performance liquid chromatography method. All analyzed samples displayed the normal elution profile, which denoted... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2816878 Sat, 19 Sep 2009 05:51:49 +0100 2816878 http://www.medworm.com/index.php?rid=2816879&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fl17x0k632n043146%2F We report herein a 29-year-old man with muscle carnitine deficiency who developed not only a lipid storage myopathy, but also a severe sensory neuropathy. Oral therapy with levo-carnitine (3 g per day) for 3 months produced a remarkable improvement of the myopathy and sensory neuropathy. Six months later, he remained in good condition under strict dietary control. This report emphasizes that severe neuropathy may occur in some patients with muscle carnitine deficiency, and highlights the need for the neurologist’s familiarity with those afflicted to achieve optimal clinical management. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0128-5Authors Wei Zhang, Fourth Military Medical University Department of Neurology, Tangdu Hospital 710038 Xi’an... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2816879 Sat, 19 Sep 2009 05:51:48 +0100 2816879 http://www.medworm.com/index.php?rid=2816881&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fu4lh83p3p7g12275%2F Abstract  A clinical and molecular overlap between Alzheimer’s disease (AD) and frontotemporal dementia (FTD) has been reported. Presenilins have been associated with FTD or with FTD-like phenotype, while mutations in the MAPT gene have been linked to a clinical phenotype of AD. We performed a clinical and genetic examination in two FTD siblings and their family tree has been reconstructed. We identified a novel Val75Ala MAPT mutation in one patient and in the other the Arg62His Presenilin2 mutation. The DNA variations identified, defined mutations by frequency, per se are not causative of the disease. These mutations, possibly in association with other unknown environmental and genetic factors, may contribute to neurodegeneration. In this family, the disease might result f... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2816881 Sat, 19 Sep 2009 05:51:47 +0100 2816881 http://www.medworm.com/index.php?rid=2816880&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F4811341558760030%2F In conclusion, in acquired copper-deficiency-associated myelopathy, correction of blood and MRI alterations precedes that of neurological manifestations, which may remain suboptimal. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0126-7Authors Laura Bolamperti, Ospedale Maggiore della Carità Clinica Neurologica C.so Mazzini, 18 28100 Novara ItalyMaurizio A. Leone, Ospedale Maggiore della Carità Clinica Neurologica C.so Mazzini, 18 28100 Novara ItalyAlessandro Stecco, Amedeo Avogadro University Department of Radiology Novara ItalyMonica Reggiani, Amedeo Avogadro University Clinica Neurologica Novara ItalyMario Pirisi, Amedeo Avogadro University Clinica Medica Novara ItalyAlessandro Carriero, Amedeo Avogadro University Department of Radiology Novara ItalyFranc... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2816880 Sat, 19 Sep 2009 05:51:47 +0100 2816880 http://www.medworm.com/index.php?rid=2816883&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft6472264n072w3w6%2F We report a 56-year-old man with a prolonged, uncontrolled hyperglycemia (HbA1C: 13.8%) and striatal hyperintensity on T1-weighted MR imaging presenting as reversible focal neurological deficit and irreversible neuroimaging abnormalities on the fourth month when blood sugar was under control (HbA1C 6.0 mg/dl). We hypothesize that neuroimaging abnormalities in our case may be a sequence of an “ischemic insult” caused by prolonged, uncontrolled hyperglycemia. Whether the signal abnormalities on neuroimaging studies or the clinical syndrome are reversible (patients with HCHB) or irreversible (such as in our case) are based on the degree of ischemic damage. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0127-6Authors Chin-Sung Tung, I-Shou University ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2816883 Sat, 19 Sep 2009 05:51:46 +0100 2816883 http://www.medworm.com/index.php?rid=2816882&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F38635053p2015304%2F Abstract  Α 62-year-old man was presented with bilateral cataract, proximal muscle weakness and difficulty in relaxing the hands after voluntary contraction. Idiopathic hypoparathyroidism was diagnosed. Electrophysiological study showed spontaneous motor unit action potentials, occurring and disappearing abruptly, as duplets, triplets and multiplets, with an intra-burst frequency of up to 100 Hz and some of them waning in amplitude, findings consistent with neuromyotonia. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-009-0140-9Authors Thomas Zambelis, University of Athens Department of Neurology, Aeghinition Hospital 74, Vassilissis Sofias Avenue 11528 Athens GreeceDimitrios Licomanos, University of Athens Department of Neurology, Aeghiniti... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2816882 Sat, 19 Sep 2009 05:51:46 +0100 2816882 http://www.medworm.com/index.php?rid=2816885&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F14866m73l1151435%2F Abstract  Neurosyphilis remains to be a challenging diagnostic possibility worldwide. The aim of our study was to identify and report the clinical and laboratory profile of neurosyphilis, comparing features of HIV-infected and HIV-negative patients. A retrospective investigation of all cases of neurosyphilis, defined as positive VDRL test on cerebrospinal fluid, diagnosed at Hospital das Clínicas, Ribeirão Preto School of Medicine between January 1988 and December 2005, was carried out. We identified 35 patients with a mean age of 42.1 years, 28.6% of them HIV infected and 74.3% of them were male. HIV-infected patients were younger (34.6 years), presented with a higher frequency of the early forms of neurosyphilis, higher titers of serum VDRL and higher mean pro... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2816885 Sat, 19 Sep 2009 05:51:42 +0100 2816885 http://www.medworm.com/index.php?rid=2816884&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F987j3431g214640v%2F The objective is to study β-amyloid (Aβ) deposition in dementia with Lewy bodies (DLB) with Alzheimer’s disease (AD) pathology (DLB/AD). The size frequency distributions of the Aβ deposits were studied and fitted by log-normal and power-law models. Patients were ten clinically and pathologically diagnosed DLB/AD cases. Size distributions had a single peak and were positively skewed and similar to those described in AD and Down’s syndrome. Size distributions had smaller means in DLB/AD than in AD. Log-normal and power-law models were fitted to the size distributions of the classic and diffuse deposits, respectively. Size distributions of Aβ deposits were similar in DLB/AD and AD. Size distributions of the diffuse deposits were fitted by a power-law model suggesting that aggreg... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2816884 Sat, 19 Sep 2009 05:51:42 +0100 2816884 http://www.medworm.com/index.php?rid=2816887&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0v0046214631p9mq%2F The objective of the study is to investigate the benefits of joining a self-help group for patients with medication overuse headache (MOH). A self-help group is a voluntary gathering of a small number of persons who share a common problem. Little is known about support groups for people with chronic non-malignant pain such as MOH. Eight patients with refractory MOH attended a self-help group twice a month. During the meetings, patients were asked to focus on their headache experiences. Our data showed an increase in resourcefulness in coping with pain and a reduction in cephalalgiophobia. All patients reported general benefits in sharing their headache-related problems. No differences were found for headache frequency or analgesic overuse. To our knowledge, this is the first report o... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2816887 Sat, 19 Sep 2009 05:51:40 +0100 2816887 http://www.medworm.com/index.php?rid=2816886&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0723964421r06551%2F This study evaluated whether the effects of treadmill training are associated with an improvement of walking economy. Ten patients with idiopathic PD underwent treadmill training (30 min, three times a week for 4 weeks). Walking performance (Τimed Up and Go, 6-min and 10-m walking tests) and metabolic function (oxygen uptake, heart and respiratory rate) were evaluated before training, at the end of treatment and after 30 days with two different graded exercises (treadmill and cycloergometer). Training significantly improved walking performance. Oxygen uptake, and heart and respiratory rates were significantly decreased only during graded exercise on the treadmill, but not on the cycloergometer. Treadmill training reduces energy expenditure during walking in PD, but th... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2816886 Sat, 19 Sep 2009 05:51:40 +0100 2816886 http://www.medworm.com/index.php?rid=2816889&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx1p17n850330246t%2F Abstract  An 18-year-old man with progressive paraparesis, thermal hypoesthesia, sweating abnormalities, bladder dysfunction, severe orthostatic hypotension, bilateral Babinski sign, underwent a brain MRI scan that showed downward displacement of cerebellar tonsils through the foramen magnum, consistent with Chiari I malformation, compression of the brainstem–spinal cord junction, and C1–D11 syringomyelia (6.5 mm diameter at C2 level) consistent with Chiari I syndrome. Suboccipital craniectomy and duraplasty were performed. A C2 partial laminectomy and ablation of posterior arch of the atlas was performed. MRI scans 4 days and 1 month after surgery showed a dramatic syringomyelia reabsorption (2.5 and 1 mm, respectively) associated with complete clini... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2816889 Sat, 19 Sep 2009 05:51:39 +0100 2816889 http://www.medworm.com/index.php?rid=2816888&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp912058082862t75%2F Abstract  The endocannabinoid system (ECS) is involved in the pathophysiology of multiple sclerosis (MS), and relief from pain and spasticity has been reported in MS patients self-medicating with marijuana. A cannabis-based medication containing Δ9-tetrahydrocannabinol and cannabidiol (Sativex®) has been approved in some countries for the treatment of MS-associated pain. The effects of this pharmaceutical preparation on other clinically relevant aspects of MS pathophysiology, however, are still unclear. In 20 MS patients, we measured the effects of Sativex® on clinically measured spasticity and on neurophysiological and laboratory parameters that correlate with spasticity severity or with the modulation of the ECS. Sativex® failed to affect spasticity and stretch reflex e... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2816888 Sat, 19 Sep 2009 05:51:39 +0100 2816888 http://www.medworm.com/index.php?rid=2816890&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fxk31745l4n7p7670%2F Abstract  The Pyramids and Palm Tree Test (PPT) is a semantic memory test that measures the capacity to access detailed semantic information about words and pictures, necessary for the identification of the analogies, which link conceptually two perceptually, and functionally distinct entities. The present study aimed to provide normative data on a large sample of the elderly Italian population (N = 464; range of age = 49–94; range of education = 3–25) on both the word and the picture versions of the PPT. Results from multiple regression analyses showed that both age and education were significant predictors of performance in both the word and the picture versions of the PPT. Therefore, norms were calculated taking into account these demogra... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2816890 Sat, 19 Sep 2009 05:51:38 +0100 2816890 http://www.medworm.com/index.php?rid=2745049&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F48850638548u8v6m%2F Abstract  Guillain–Barré syndrome (GBS) is an acute inflammatory demyelinating peripheral nerve disorder. It is known that gadolinium enhancement on magnetic resonance imaging (MRI) reflects alteration of the blood–nerve barrier secondary to inflammation. Enhancement of the cauda equina roots with gadolinium on lumbosacral magnetic resonance imaging have been demonstrated in several reports. Although about 50% of GBS patients clinically exhibit facial nerve involvement, it has never been demonstrated on MRI. We aimed to observe facial nerve involvement in a GBS patient who has prominent facial diplegia. With the guidance of the literature, we predict that MRI in selected GBS patients may be an adjunct tool for the clinician in both diagnosis and monitoring the treatmen... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2745049 Fri, 28 Aug 2009 15:00:15 +0100 2745049 http://www.medworm.com/index.php?rid=2723745&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff1l5464696036k13%2F In this study, we observed that BSA induced significant upregulation of mRNA expression and release of pro-inflammatory cytokines, IL-1β, and TNF-α, by N9 microglial cells. Our results suggest that the effects of BSA should be taken into account in experiments on microglia or the central nervous system when BSA is used. In light of the high similarity and homology among mammalian albumins, our findings also indicate that serum albumin may be a potent trigger of cytokine release by microglia. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-009-0123-xAuthors Tian-zhi Zhao, The Third Military Medical University Department of Neurosurgery, Southwest Hospital Chongqing 400038 ChinaYong-zhi Xia, The Third Military Medical University Department of Neurosurgery, ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2723745 Fri, 21 Aug 2009 11:11:10 +0100 2723745 http://www.medworm.com/index.php?rid=2706808&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp4584064g42647t2%2F Abstract  Hyperglycemic status may be rarely complicated by Epilepsia partialis continua (EPC) that usually responds to metabolic normalization. Anti-glutamic acid decarboxylase antibodies (GAD-Ab) play a pivotal role in the autoimmune process that leads to clinical onset of type 1 diabetes mellitus (T1DM). GAD-Ab have been recently reported in association with rare forms of refractory epilepsy, with or without association to T1DM. Here we describe a young patient who developed EPC five months after T1DM onset; GAD-Ab were detected in his cerebrospinal fluid with evidence of oligoclonal bands. His epileptic disorder evolved over time into drug-resistant epilepsy with continuous spike-waves during slow sleep and severe behavioral impairment. The role of both metabolic imbalan... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2706808 Sat, 15 Aug 2009 09:36:58 +0100 2706808 http://www.medworm.com/index.php?rid=2706809&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ff7l4l739048xg057%2F We report an unusual case of Parsonage–Turner syndrome with relapses and simultaneous bilateral anterior interosseous neuropathy (AIN). A 66-year-old man, after a typical right brachial amyotrophic neuralgia few months previously, underwent surgery for left carpal tunnel syndrome. The day following surgery, wrist aching and bilateral weakness, even if prevalent on the right side, on thumb and index finger flexion appeared. Neurophysiology was consistent with bilateral AIN neuropathy and serology revealed anti-nucleus antibody positivity. Association of relapses with bilateral acute AIN involvement in the subject with autoantibody detection can suggest an immunological pathogenesis. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0124-9Authors Giovanna Squ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2706809 Sat, 15 Aug 2009 09:36:56 +0100 2706809 http://www.medworm.com/index.php?rid=2706810&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7346x03278370620%2F We describe a patient with a sporadic form of amyotrophic lateral sclerosis (ALS) in which a heterozygous A > C exchange at position 272 in the SOD1 gene was detected. This mutation results in an amino acid substitution of alanine for aspartate at position 90 (D90A). The patient had a 12-year history of disease characterized by slow progression. Clinical examination at last follow-up revealed predominant upper motor neuron (p-UMN) involvement, with atrophies only in distal muscle of upper limbs. Electrophysiological examination revealed lower and upper motor neuron involvement. Family history was negative for neurological disease. This report shows that D90A in heterozygous state may cause p-UMN phenotype with very slow progression. Content Type Journal ArticleCategory... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2706810 Sat, 15 Aug 2009 09:36:51 +0100 2706810 http://www.medworm.com/index.php?rid=2706811&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx5w57qw91n5l2847%2F We report the case of patient affected by calculation-induced seizures that were refractory to medications. We showed the cortical activation by using a functional magnetic resonance imaging (fMRI) while he was performing an arithmetic task and illustrated that, in this case, the areas commonly activated included the premotor and supplementary motor areas of both hemispheres. Furthermore, the patient showed a more significant activation of posterior parietal and prefrontal cortices after arithmetic tasks if compared to normal controls. To our knowledge, this is the first fMRI study in calculation-induced seizures, even if limited to a single patient. The potential benefits of non-conventional neuroimaging technology, such as fMRI, for understanding calculation, however, are only beg... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2706811 Sat, 15 Aug 2009 09:36:44 +0100 2706811 http://www.medworm.com/index.php?rid=2643166&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fp4380l2711896514%2F Abstract  Posterior reversible leukoencephalopathy (PRLE) is a neurological disorder caused by a variety of pathological conditions such as high doses or long-term low-doses of immunosuppressive therapy. PRLE associated with methotrexate (MTX) is well known but it was rarely observed in adult patients submitted to long-term low-dose administration via the oral route. Here we report the case of a patient affected by psoriasis, treated by chronic oral low-dose of MTX, who presented with limb ideomotor apraxia. Magnetic resonance (MRI) of the brain showed, on T2-weighted images, a diffuse hyperintensity involving bilaterally the white matter of the occipital, parietal and frontal lobes. MTX treatment was stopped and, at the 6-month follow-up, the neuropsychological performance... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2643166 Fri, 24 Jul 2009 23:51:11 +0100 2643166 http://www.medworm.com/index.php?rid=2623740&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgw67v4wk8g648847%2F Abstract  Schilder’s disease, or myelinoclastic diffuse sclerosis, is a rare disorder characterised by an inflammatory white matter plaque of demyelination. Clinical signs and symptoms might be atypical for early multiple sclerosis and at imaging the lesion is easily taken for a brain tumour. Regardless of the use of Poser’s criteria for clinical diagnosis of Schilder’s disease proposed in 1986, diagnostic difficulties are still present, as evidenced by the many reported cases in the English literature revised (Pubmed indexed, period 1998–2008). It clearly emerges that neuroradiological features, observable in additional magnetic resonance sequences are crucial, besides the consideration of Poser’s criteria, in differentiating between demyelinating lesions and bra... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2623740 Sat, 18 Jul 2009 21:13:05 +0100 2623740 http://www.medworm.com/index.php?rid=2604150&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fn67p550w76653q83%2F We report a 63-year-old Italian woman harboring the E200K PRNP mutation. Electroencephalogram, cerebrospinal fluid analysis, PRNP gene sequencing, histopathologic examination, immunohistochemical studies, and Western blotting analysis confirmed the diagnosis of CJD. Pyramidal involvement was the first sign and the prominent clinical feature. Later on, she developed also myoclonus, ataxia, spastic tetraplegia, and at last dementia with akinetic mutism. Usually, signs of degeneration of the pyramidal tracts occur in a small number of patients as the disease advances. Our report supports the variability of the clinical expression of the E200K genetic CJD. Further studies are needed to understand the molecular basis underlying the phenotypic variability among patients carrying this mutati... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2604150 Tue, 14 Jul 2009 10:03:06 +0100 2604150 http://www.medworm.com/index.php?rid=2592440&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc7655730m1253320%2F Abstract  The study aimed to characterize neuropsychiatric symptomatology in Alzheimer’s disease (AD) and investigate the role of APOE genotype and other clinical variables in the onset of neuropsychiatric disorders. Moreover, an attempt to study the evolution of behavioral and psychiatric symptoms was made. Fifty-three consecutive outpatients with AD were enrolled. Twenty-four were followed longitudinally for 1 year. MMSE was used to evaluate cognitive functions. The neuropsychiatric inventory (NPI) was administered to assess behavioral and psychiatric symptoms. Genotyping was determined through laboratory testing. At baseline, no specific neuropsychiatric disorder was significantly associated with ApoE genotype, but associated with a peculiar neuropsychiatric profi... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2592440 Fri, 10 Jul 2009 08:14:48 +0100 2592440 http://www.medworm.com/index.php?rid=2592439&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fc2665044133103n2%2F Abstract  Clinical manifestations of flavivirus infection may be various, from unapparent to severe meningoencephalitis. Our patient, 2 weeks after returning home from a holiday at Elba Island, developed biphasic fever, later associated with nausea and vomiting and followed by incoming seizures responsive to thiopental sodium only. Brain MRI showed bilateral hyperintensity (T2) in amygdale, hippocampus, left insular and temporal inferior cortex. Standard and microbiological CSF examination was normal, but microbiological serum analysis showed seroconversion for flavivirus. The patient came to our observation 6 months after disease onset and at that time he was affected by frequent seizures and severe cognitive impairment with behavioural disturbances; the patient ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2592439 Fri, 10 Jul 2009 08:14:48 +0100 2592439 http://www.medworm.com/index.php?rid=2592441&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fk421227860154276%2F Abstract  This case attempts to explicit the importance of clinical examination in the differential diagnosis of two similar clinical entities namely astereognosia and stereoanesthesia. The patient presented below involves a multiple sclerosis patient whose symptoms were considered at first to be a case of astereognosia since she mainly complained of an inability to recognize and name the form and nature of objects by touch. However, a thorough clinical examination and the results of neurophysiological and neuroimaging testing demonstrated that it involved a case of stereoanesthesia due to a demyelinating lesion at the cervical region of the spinal cord. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0117-8Authors E. Kararizou, Athens National Un... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2592441 Thu, 09 Jul 2009 12:11:22 +0100 2592441 http://www.medworm.com/index.php?rid=2578630&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Ft2421mu807h31237%2F Abstract  Restless legs syndrome (RLS) has been frequently reported in association with peripheral neuropathy, and it is especially frequent in some forms of polyneuropathy with preferential involvement of small sensory fibers. Here, we describe a patient with multifocal motor neuropathy, who developed RLS during the course of the disease. Our findings support the notion that RLS may develop in the context of immune-mediated neuropathies and it should be specifically investigated even in those patients with preferentially or exclusive motor involvement. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0111-1Authors Daniele Lo Coco, Ospedale Civico, ARNAS U.O. Neurologia, Dipartimento di Neuroscienze P.za N. Leotta 4 90129 Palermo ItalyEmanuele Canni... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2578630 Mon, 06 Jul 2009 17:07:54 +0100 2578630 http://www.medworm.com/index.php?rid=2578631&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F24781q2101434257%2F We report a 33-year-old woman who had aseptic meningitis alone, without any other systemic manifestations, due to Behçet’s disease. Behçet’s disease should be listed as a differential diagnosis of acute aseptic meningitis because, in acute aseptic meningitis caused by Behçet’s disease, early treatment with corticosteroids could ameliorate this disorder. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0109-8Authors Ryuji Sakakibara, Sakura Medical Center, Toho University Neurology Division, Department of Internal Medicine 564-1 Shimoshizu Sakura 285-8741 JapanNobukiyo Koide, Sakura Medical Center, Toho University Endocrinology and Metabolism Division, Department of Internal Medicine Sakura JapanMasahiko Kishi, Sakura Medical Center, Toho University Neu... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2578631 Mon, 06 Jul 2009 17:07:53 +0100 2578631 http://www.medworm.com/index.php?rid=2565594&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx5h7j42700158422%2F Abstract  Hyperhomocysteinemia and factors of homocysteine metabolism, S-adenosylhomocysteine (AdoHcy) and S-adenosylmethionine (AdoMet), may play a role in Alzheimer’s disease (AD). With liquid-chromatography-tandem-mass-spectrometry AdoMet and AdoHcy were determined in brains of 8- and 15-month-old APP/PS1 Alzheimer mice, and their possible roles in AD brains investigated. The finding that AdoMet levels do not differ between the genotypes in (young) 8-month-old mice, but are different in (older) 15-month-old APP/PS1 mice compared to their wild-type littermates, suggests that alterations in AdoMet are a consequence of AD pathology rather than a cause. During aging, AdoMet levels decreased in the brains of wild-type mice, whereas AdoHcy levels diminished in both wild type ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2565594 Tue, 30 Jun 2009 15:44:29 +0100 2565594 http://www.medworm.com/index.php?rid=2565595&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fjq8504287k8x8246%2F We describe here a 63-year-old woman who presented to our local hospital with an acute, bilateral visual loss followed by progressive paraparesis. Medical evaluations revealed a lung tumor and spinal MRI showed multiple cervical-dorsal hyperintense T2 lesions with mild mass effect. Testing for NMO-Ig resulted positive. Patient’s diagnosis was thus consistent with a possible paraneoplastic neuromyelitis optica associated with non-small cell lung cancer and evidence of NMO-Ig. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0112-0Authors Giuseppe De Santis, Institute of Clinical Neurology Department of Medical-Surgical Disciplines, Communication and Behaviour Corso Giovecca, 203 44100 Ferrara ItalyLuisa Caniatti, Institute of Clinical Neurology Department of ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2565595 Tue, 30 Jun 2009 15:44:19 +0100 2565595 http://www.medworm.com/index.php?rid=2565596&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F283q61015t6j4j18%2F Abstract  Spinal anesthesia (SA), accounting for more than 50% of regional anesthesias in the spinal region, is generally perceived as simple and safe. Our purpose is to increase awareness of hemorrhagic complications following SA. A 69-year-old male without either coagulation disorders or anticoagulant/antiplatelet therapy developed acute radiculopathy, and severe mental confusion after SA for prostatectomy. CT showed intracranial subarachnoid and intraventricular acute hemorrhage. Cerebral angiography was negative. MRI showed subarachnoid and subdural hematoma in the dorsolumbar spine. Seven-year follow-up showed permanent cognitive and radicular damage. Multiple attempts for SA most likely caused spinal vessels rupture, either directly or indirectly by inducing different... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2565596 Tue, 30 Jun 2009 15:44:18 +0100 2565596 http://www.medworm.com/index.php?rid=2549694&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fr754481p7p745316%2F Abstract  Breathing disturbances in Rett syndrome were reported almost entirely during wakefulness, with normal respiration during sleep. We studied a case of a proven MECP2 mutation in a girl, whose videopolygraphic and polysomnographic monitoring suggested the evidence of central apnoeas not only during awake, but also during sleep. Apart from prevalent awake respiratory dysfunction, central apnoeas in Rett syndrome may be also present during sleep. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0108-9Authors Giuseppe d’Orsi, Opera Don Uva Epilepsy Center, Neurological Unit, Casa Divina Provvidenza Via Bovio 78 70052 Bisceglie (BAT) ItalyVincenzo Demaio, Opera Don Uva Epilepsy Center, Neurological Unit, Casa Divina Provvidenza Via Bovio 78 7005... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2549694 Thu, 25 Jun 2009 07:39:24 +0100 2549694 http://www.medworm.com/index.php?rid=2492154&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy71x31770m045r11%2F Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10072-009-0105-zAuthors Francesco Raudino, “Valduce” Hospital Department of Neurology Via Dante 11 22100 Como ItalyFrancesco Muscia, “Valduce” Hospital Department of Neurology Via Dante 11 22100 Como ItalyMaurizio Osio, “L. Sacco” Hospital Department of Neurology Milan Italy Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2492154 Wed, 17 Jun 2009 09:43:17 +0100 2492154 http://www.medworm.com/index.php?rid=2492153&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F010713667g68552n%2F In this study, we reviewed 36 patients from six neurological referral centres: Department of Pediatrics, Chieti (3 patients); Department of Child Neuropsychiatry, Naples (9 patients); Department of Child Neuropsychiatry, Bologna (8 patients); Department of Neuroscience, Tor Vergata University, Rome (3 patients); Department of Pediatrics, La Sapienza University, Rome (5 patients); and Department of Pediatrics, Siena (8 patients). The population was divided according to Tanner’stages into 14 prepubertal (group I) and 22 pubertal (group II) patients. The two groups were compared on several variables examining the differences between them. The most frequent clinical manifestations in group I were unresponsive events, whereas in group II, motor events were exhibited more significantly. ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2492153 Wed, 17 Jun 2009 09:43:17 +0100 2492153 http://www.medworm.com/index.php?rid=2492152&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fgu5052507333531v%2F Abstract  Myasthenia gravis (MG) can rarely be manifested with ocular motility disturbances, simulating internuclear ophthalmoplegia. Pseudo-internuclear ophthalmoplegia (PINO) may occur during the course of MG, however, the initial presentation of MG with PINO in rather unlikely. We herein describe the case of a male patient who developed PINO, as an initial manifestation of MG. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0106-yAuthors Andreas A. Argyriou, “Saint Andrew’s” General Hospital of Patras Department of Neurology 26335 Patras GreecePanagiotis Karanasios, “Saint Andrew’s” General Hospital of Patras Department of Neurology 26335 Patras GreeceCharalabos Potsios, “Saint Andrew’s” General Hospital of Patras Department of ... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2492152 Wed, 17 Jun 2009 09:43:17 +0100 2492152 http://www.medworm.com/index.php?rid=2480503&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F0h7u807j3713306m%2F We report the first case of a patient with severe Alzheimer’s disease who presented with non-epileptic myoclonus just after haloperidol treatment was initiated. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0104-0Authors Cristina Domínguez, University Hospital “12 de Octubre” Department of Neurology Madrid SpainJulián Benito-León, University Hospital “12 de Octubre” Department of Neurology Madrid SpainFélix Bermejo-Pareja, University Hospital “12 de Octubre” Department of Neurology Madrid Spain Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2480503 Sat, 13 Jun 2009 08:23:08 +0100 2480503 http://www.medworm.com/index.php?rid=2480504&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F268rh0p026x703q8%2F We report a preliminary evaluation of a questionnaire to assess the presence of these impulsive–compulsive behaviours associated to dopamine replacement therapy in PD. We screened 38 patients and their caregivers, comparing dopamine dysregulation syndrome (DDS) patients and non-DDS patients. The questionnaire was well accepted and demonstrated a preliminary good discriminant validity (p = 0.000). In addition, clinically relevant dysregulated condition is associated with a younger age (p = 0.006), younger age at disease onset (p = 0.001), levodopa-equivalent daily dose (p = 0.029), UPDRS III (p = 0.021), increased global psychopathology (interpersonal sensitivity and psychoticism), and differences in our inventory (p = 0.000)... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2480504 Wed, 10 Jun 2009 09:54:11 +0100 2480504 http://www.medworm.com/index.php?rid=2460833&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fy07t5477112u2g90%2F In conclusion, although the prognosis of ULD has progressed, there are still spontaneously severe forms and high risk of early death, including SUDEP. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10072-009-0102-2Authors Hela Mrabet Khiari, Charles Nicolle Hospital Neurological Department Boulevard 9 Avril 1006 Tunis TunisiaSilvana Franceschetti, Besta Neurological Institute Department of Neurology Milan ItalyNebojsa Jovic, Clinic of Neurology and Psychiatry for Children and Youth Belgrade SerbiaAmel Mrabet, Charles Nicolle Hospital Neurological Department Boulevard 9 Avril 1006 Tunis TunisiaPierre Genton, Centre Saint Paul-Henri Gastaut Marseille France Journal Neurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 (Source: Neurological Sciences) Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2460833 Fri, 05 Jun 2009 08:57:09 +0100 2460833 http://www.medworm.com/index.php?rid=2460834&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F785357730m8114g7%2F Abstract  The aim of this study was to assess the ability of a single SPECT performed in the early stage of Parkinson’s disease (PD) to predict disease severity in 19 patients with early PD. [123I]-FP-CIT striatal uptake was expressed as a ratio of specific:nonspecific uptake for defined brain areas. Clinical severity was determined by the UPDRS at baseline and 12–15 months following the SPECT procedure. [123I]-FP-CIT uptake in the contralateral putamen and striatum was correlated with UPDRS score at baseline, with a more significant correlation after 1-year interval. [123I]-FP-CIT uptake in all areas was correlated with bradykinesia and rigidity subscores only at follow up visit. Significant correlations were found between [123I]-FP-CIT uptake in the contralateral s... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2460834 Fri, 05 Jun 2009 08:57:08 +0100 2460834 http://www.medworm.com/index.php?rid=2460835&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fm716835ukrvw7172%2F Abstract  Tuberculomas are common forms of central nervous system tuberculosis, presenting as space-occupying-lesions. Brainstem tuberculomas are rare among all intracranial tuberculomas. In old patients, in the absence of tuberculosis history, diagnosis may be challenging. In this case, we present a 70-year-old patient, with bladder cancer, without known tuberculosis who presented with stroke-like symptoms, clinically. Diffusion-weighted imaging revealed no finding of stroke, however, a medulla oblongata tuberculoma, mimicking metastasis was evident on MRI. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10072-009-0099-6Authors Fuldem Yildirim Donmez, Baskent University Faculty of Medicine Department of Radiology 46. Sokak No: 11/8, Bahcelievler Ankara Turk... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2460835 Thu, 04 Jun 2009 11:17:17 +0100 2460835 http://www.medworm.com/index.php?rid=2460836&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F57273717r8l73642%2F Abstract  To evaluate the prevalence of migraine and related disability and the role of ID migraine questionnaire as a screening tool in patients with temporomandibular disorders (TMDs) and craniofacial pain (CFP). TMDs patients with CFP underwent stomatognathic (RDC/TMD criteria) and neurological visits (IHS criteria, 2004). ID migraine questionnaire and MIgraine Disability Assessment Scale (MIDAS) were also administered. Out of 45 patients, 69% met diagnosis of migraine plus chronic tension-type headache (CTTH); 9% presented CTTH and 20% were migraineurs. Out of 39 migraineurs who completed MIDAS, 56% presented the highest disability grade. Out of 37 patients who completed ID migraine questionnaire, 32 resulted affected by probable migraine with a diagnostic sensibility a... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2460836 Thu, 04 Jun 2009 11:17:16 +0100 2460836 http://www.medworm.com/index.php?rid=2450382&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2F7104l69523452318%2F Abstract  Blood levels of total homocysteine (tHcy), cysteine (Cys), total and reduced glutathione (tGSH and rGSH), folic acid (FA), and vitamin B12 (B12) change during ischemic stroke as accompaniment of the tissue damage. The relationship between these changes remains scantly investigated. We evaluated the variation of these molecules in the 48 h after acute large artery atherothrombotic stroke (LAAS) and searched for the presence of matched variation of them. The study involved 50 subjects affected by acute LAAS and 49 healthy controls. Plasma levels of tHcy and Cys were significantly higher and serum levels of FA and B12 and plasma levels of rGSH were significantly lower in the patients than in the control group. Acute LAAS was associated with increased Hcy—decrea... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2450382 Sat, 30 May 2009 07:46:20 +0100 2450382 http://www.medworm.com/index.php?rid=2450383&cid=s_33319_25_f&fid=33319&url=http%3A%2F%2Fwww.springerlink.com%2Fcontent%2Fx414055p8161060t%2F In this study, we used a bioplex assay to simultaneously measure the levels of 23 plasma cytokines in 18 patients with late-life depression and 38 normal controls, and these levels were compared between the two groups. The plasma interleukin-1alpha (IL-1α) levels were found to be significantly different between the two groups. After adjusting for age, gender, low-density lipoprotein cholesterol, and triglyceride, the plasma IL-1α levels were significantly higher in the patients with late-life depression than in the normal control subjects. Thus, this study provides preliminary evidence that plasma IL-1α may play important roles in the pathogenesis of late-life depression. Content Type Journal ArticleCategory Brief CommunicationDOI 10.1007/s10072-009-0091-1Authors Kang Soo Lee,... Neurological Sciences journals http://www.medworm.com/rss/comments.php?id=2450383 Sat, 30 May 2009 07:46:19 +0100 2450383