MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Neuroscience Research Communications' source. Sat, 10 Oct 2009 19:35:13 +0100 http://www.medworm.com/index.php?rid=219810&cid=s_33783_168_f&fid=33783&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fnrc.20037 The author describes a refiguration of medical thought which originate from non linear dynamics and chaos theory. The coupling of computer science and these new theoretical bases allows the creation of "intelligent" agents (Artificial Adaptive Systems AAS) able to adapt themselves dynamically to problem of high complexity like Alzheimer Disease. ASS are able to reproduce the dynamical interactio of multiple factors simultaneously, allowing the study of complexity; they can also draw conclusions on individual basis and not as average trends. In the last years of co-operation between ITINAD, Bracco Medical Department and Semeion Research Centre different kinds of experiments have been performed with ANNs in Alzheimer Disease context. The specific application of ANN in most cases is original,... Neuroscience Research Communications journals http://www.medworm.com/rss/comments.php?id=219810 Wed, 04 Oct 2006 15:20:02 +0100 219810 http://www.medworm.com/index.php?rid=219809&cid=s_33783_168_f&fid=33783&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fnrc.20036 Here we summarise current knowledge about biological markers available for early Alzheimer Disease detection. In fact delineating disease process from "normal ageing" may be difficult in the very early stages; in later stages of the disease distinguishing Dementia of Alzheimer Type from a number of neurodegenerative diseases associated with dementia may also be troublesome. (Source: Neuroscience Research Communications) Neuroscience Research Communications journals http://www.medworm.com/rss/comments.php?id=219809 Wed, 04 Oct 2006 15:20:02 +0100 219809 http://www.medworm.com/index.php?rid=219808&cid=s_33783_168_f&fid=33783&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fnrc.20035 This review discusses the phosphorylation of the Amyloid Precursor Protein (APP) and the possible role of this phosphorylation in Alzheimer's disease (AD). AD is a neurodegenerative disorder characterized by the deposition of [bgr]-amyloid plaques in the brain parenchyma and neurofibrillary tangles comprised of hyperphosphorylated tau. APP plays a primary role in the pathogenesis of AD, because its processing generates the amyloid beta peptide (A[bgr]), the core of the amyloid plaque. APP has a large N-terminal extracellular domain and a short intracellular C-terminal domain that can be phosphorylated by various protein kinases. This review summarized recent work describing the phsphorylation of APP and the downstream events induced by this phosphorylation as well as the impact of APP phos... Neuroscience Research Communications journals http://www.medworm.com/rss/comments.php?id=219808 Wed, 04 Oct 2006 15:20:02 +0100 219808 http://www.medworm.com/index.php?rid=219807&cid=s_33783_168_f&fid=33783&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fnrc.20034 Age has a powerful effect on enhanced susceptibility to cardiovascular diseases, stroke, cognitive impairment and neurodegenerative diseases and a condition of increased oxidative stress status seems to be the link factor. In this paper we briefly reviewed the more recently reports on the role of oxidative stress in aging and age-related diseases with a specific focus on mild cognitive impairment and Alzheimer's disease. The role of antioxidant therapy and/or supplementation and the importance of an antioxidant rich diet are then discussed. (Source: Neuroscience Research Communications) Neuroscience Research Communications journals http://www.medworm.com/rss/comments.php?id=219807 Wed, 04 Oct 2006 15:20:02 +0100 219807 http://www.medworm.com/index.php?rid=219806&cid=s_33783_168_f&fid=33783&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fnrc.20033 Alzheimer's Disease (AD) is a neurodegenerative disorder characterised by abnormal fibrillar deposits of amyloid beta peptides (A[bgr]), which are suggested to play a pivotal role in driving disease pathogenesis. Although the aetiology of AD is still unknown, a perturbation of the immune system has been widely demonstrated in both animal experimental models and patients. The most studied aspect of immune reaction in AD is inflammation, which has been described to be implied in its pathogenic processes. Moreover, a growing body of evidence, indicating that the triggering of the specific A[bgr] immune response can be effective in reducing AD sympotoms, suggest that a dysregulated network of innate and adaptive immune mechanismsm could be critical in AD pathogenic process. The present short r... Neuroscience Research Communications journals http://www.medworm.com/rss/comments.php?id=219806 Wed, 04 Oct 2006 15:20:02 +0100 219806 http://www.medworm.com/index.php?rid=219805&cid=s_33783_168_f&fid=33783&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fnrc.20032 Conclusion: These results supports the use of the MDB in the screening phase of AD patients and of ADAS-Cog to follow the progression of cognitive decline over time. (Source: Neuroscience Research Communications) Neuroscience Research Communications journals http://www.medworm.com/rss/comments.php?id=219805 Wed, 04 Oct 2006 15:20:02 +0100 219805 http://www.medworm.com/index.php?rid=219804&cid=s_33783_168_f&fid=33783&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fnrc.20031 Non cognitive symptoms are almost always present in dementia with important consequences for patients and caregivers quality of life. Behavioural and Psychological Symptoms of Dementia (BPSD) are heterogeneous and varied in relation to the stage of the demetia and to the aetiology. Treatment of behavioral and psychological symptoms of dementia represent an important challenge, and non pharmacological and pharmacological approach needs. Antidepressant and neuroleptics are the most frequently used drugs in the treatment of BPSD, even if the number of well designed controlled studies are limited. A variety of different forms of environmental and rehabilitative interventions showed efficacy on BPSD. (Source: Neuroscience Research Communications) Neuroscience Research Communications journals http://www.medworm.com/rss/comments.php?id=219804 Mon, 01 Nov 2004 07:00:00 +0100 219804