MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Nuclear Medicine and Biology' source. Thu, 09 Feb 2012 03:37:48 +0100 http://www.medworm.com/index.php?rid=5652113&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111003192%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652113 Wed, 01 Feb 2012 05:00:00 +0100 5652113 http://www.medworm.com/index.php?rid=5652097&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111003155%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652097 Wed, 01 Feb 2012 05:00:00 +0100 5652097 http://www.medworm.com/index.php?rid=5563476&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111002782%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563476 Sun, 01 Jan 2012 05:00:00 +0100 5563476 http://www.medworm.com/index.php?rid=5563458&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111002691%2Fabstract%3Frss%3Dyes The editorial board of Nuclear Medicine and Biology would like to wish you a happy new year and thank you for your support of the journal over the past year. Over the past 5 years, we have instituted a series of editorials that address design issues in the radiopharmaceutical sciences. If you are interested in writing an editorial, please contact the editor-in-chief. If you have comments on the editorials, please submit a letter to the editor on the automated author's system at http://www.nucmedbio.com. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563458 Sun, 01 Jan 2012 05:00:00 +0100 5563458 http://www.medworm.com/index.php?rid=5563457&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111002745%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563457 Sun, 01 Jan 2012 05:00:00 +0100 5563457 http://www.medworm.com/index.php?rid=5652109&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001880%2Fabstract%3Frss%3Dyes Conclusion: 4-[18F]-ADAM appears to be a highly selective radioligand for imaging SERT in monkey brain. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652109 Fri, 02 Dec 2011 05:00:00 +0100 5652109 http://www.medworm.com/index.php?rid=5652107&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111002150%2Fabstract%3Frss%3Dyes Conclusions: The simple linear model presented is not able to properly describe the biokinetics of 18F-choline as measured in prostatic cancer patients. The introduction of nonlinear kinetics, although based on physiologically plausible assumptions, resulted in nonsignificant improvements of the model predictive power. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652107 Fri, 02 Dec 2011 05:00:00 +0100 5652107 http://www.medworm.com/index.php?rid=5652110&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001909%2Fabstract%3Frss%3Dyes Conclusions: We describe an [11C]acetate PET rest–stress protocol for the assessment of congestive heart failure in rats and its application to the follow-up of cardiotoxicity under doxorubicin chemotherapy. This is a rapid and reliable approach to the measurement of cardiac perfusion and oxygen consumption reserve that could be applied to the development of new strategies to reduce the cardiotoxicity of anthracycline. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652110 Mon, 14 Nov 2011 05:00:00 +0100 5652110 http://www.medworm.com/index.php?rid=5652106&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111002149%2Fabstract%3Frss%3Dyes Abstract: Introduction: The overexpression of epidermal growth factor receptor (EGFR) in tumors underlines the recent interest in EGFR as attractive target for the development of new cancer imaging agents. EGFR-tyrosine kinase inhibitors (EGFR-TKIs) based on the anilinoquinazoline scaffold have been explored as potential probes for EGFR imaging. However, up to now, no optimal radiotracer is available. Herein, we report the synthesis and biological evaluation of three novel halogenated 6-substituted 4-anilinoquinazoline based EGFR-TKIs. Radiosynthesis (125I and 18F) of the corresponding analogues was also performed.Methods: 6a, 6b and 8 were obtained by reaction of 6-amino-4-anilinoquinazoline (5) with 3-/4-iodobenzoyl and 4-fluorobenzoyl chlorides. Inhibition of EGFR autophosphorylation an... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652106 Mon, 14 Nov 2011 05:00:00 +0100 5652106 http://www.medworm.com/index.php?rid=5652102&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS096980511100196X%2Fabstract%3Frss%3Dyes Conclusions: The heart uptake mechanism of 99mTc-TMEOP is similar to that of the other reported monocationic 99mTc cardiac agents and is associated with its accumulation in the mitochondria. Cyclosporin A studies indicate that the fast liver and kidney clearance kinetics is mediated by P-glycoprotein (Pgp), supporting the potential interest of this radiotracer for imaging Pgp function associated with multidrug-resistant tumours. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652102 Mon, 14 Nov 2011 05:00:00 +0100 5652102 http://www.medworm.com/index.php?rid=5563473&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001831%2Fabstract%3Frss%3Dyes Conclusion: Suitable performances could be reached by proper combinations of dose, injection volume and concentration for a specific radiotracer used in sentinel lymph node detection. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563473 Mon, 14 Nov 2011 05:00:00 +0100 5563473 http://www.medworm.com/index.php?rid=5563464&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001521%2Fabstract%3Frss%3Dyes Conclusion: FES PET imaging was able to reliably differentiate between tumors having differences in their ERα expression in vivo, in a mouse model. Quantitative data obtained by FES PET were in concordance with biodistribution studies and in vitro assays. It is concluded that FES PET imaging can likely be used to monitor subtle ER status changes during the course of hormone therapy. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563464 Mon, 14 Nov 2011 05:00:00 +0100 5563464 http://www.medworm.com/index.php?rid=5652100&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001958%2Fabstract%3Frss%3Dyes Conclusion: Based on these in vitro data, the agonist 64Cu-CB-TE2A-Y3-TATE demonstrates the most promise as an agent for targeted radiotherapy in p53 positive, SSTr2-positive tumors. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652100 Mon, 07 Nov 2011 05:00:00 +0100 5652100 http://www.medworm.com/index.php?rid=5470939&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111002678%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470939 Tue, 01 Nov 2011 04:00:00 +0100 5470939 http://www.medworm.com/index.php?rid=5470922&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111002551%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470922 Tue, 01 Nov 2011 04:00:00 +0100 5470922 http://www.medworm.com/index.php?rid=5652112&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001946%2Fabstract%3Frss%3Dyes Conclusion: Although differing in approach, the two most widely used regulatory frameworks (those in the USA and the EU) do not differ substantially with regard to the maximum allowable injected activity per PET study. The predictive validity of animal dosimetry models is critically discussed in relation to human dosimetry. Finally, empirical PET data are related to human dose estimates based on homogenous distribution, generic models and maximum cumulated activities. Despite the contribution of these models to general risk estimation, human dosimetry studies are recommended where continued use of a new PET tracer is foreseen. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652112 Fri, 28 Oct 2011 04:00:00 +0100 5652112 http://www.medworm.com/index.php?rid=5652111&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001934%2Fabstract%3Frss%3Dyes Conclusions: The results in nonhuman primates suggest that [18F]FE-PE2I is suitable for accurate and stable DAT quantification, and its radiation dose estimates would allow for a maximal administered radioactivity of 476 MBq in human subjects. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652111 Fri, 28 Oct 2011 04:00:00 +0100 5652111 http://www.medworm.com/index.php?rid=5652104&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001922%2Fabstract%3Frss%3Dyes Conclusions: [18F]LBT-999 is N-dealkylated in vivo to yield (1) a nonradioactive metabolite that crosses the BBB and has a high affinity for the DAT and (2) a [18F]fluoro-alkyl chain which is further defluorinated. The temporal changes in distribution volumes are consistent with the accumulation of a radiometabolite(s) in the brain. Therefore, the quantification of DAT density with [18F]LBT-999 is rather difficult. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652104 Fri, 28 Oct 2011 04:00:00 +0100 5652104 http://www.medworm.com/index.php?rid=5652099&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001971%2Fabstract%3Frss%3Dyes Conclusions: 64Cu-ATSM accumulated in cells with overreduced states due to mitochondrial dysfunction, even under normoxia. We recently reported that 62Cu-ATSM-PET can visualize stroke-like episodes maintaining oxygen supply in MELAS patients. Taken together, our data indicate that ⁎Cu-ATSM uptake reflects overreduced intracellular states, despite oxygenic conditions; thus, ⁎Cu-ATSM would be a promising marker of intracellular overreduced states for disorders with mitochondrial dysfunction, such as MELAS, Parkinson's disease and Alzheimer's disease. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652099 Fri, 28 Oct 2011 04:00:00 +0100 5652099 http://www.medworm.com/index.php?rid=5652098&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001910%2Fabstract%3Frss%3Dyes Conclusions: [18F]Ex(9–39) was successfully prepared and used for PET imaging for the first time to measure pancreatic BCM. The results suggest that derivatization of the Lys27 residue might reduce binding affinity, as evidenced by the absence of specific binding. Exendin analogues radiolabeled at other sites may elucidate the active site required for binding. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652098 Fri, 28 Oct 2011 04:00:00 +0100 5652098 http://www.medworm.com/index.php?rid=5563472&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS096980511100182X%2Fabstract%3Frss%3Dyes Conclusions: The radiolabeled isatins appear to bind specifically to caspase-3 in vivo, but their sensitivity is limited. Further optimization is required for these tracers to be useful for clinical applications. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563472 Fri, 28 Oct 2011 04:00:00 +0100 5563472 http://www.medworm.com/index.php?rid=5307272&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111002034%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307272 Sat, 01 Oct 2011 04:00:00 +0100 5307272 http://www.medworm.com/index.php?rid=5307254&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001995%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307254 Sat, 01 Oct 2011 04:00:00 +0100 5307254 http://www.medworm.com/index.php?rid=5652108&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001855%2Fabstract%3Frss%3Dyes This study was designed to determine the antiproliferative effects of combination gene therapy using sodium iodide symporter (NIS)-based radioiodine and lentivirus-mediated short hairpin RNA (shRNA) against hexokinase II (HKII) on vascular smooth muscle cells (VSMCs).Methods: A7r5 rat VSMCs were stably transfected with a dual-expression vector of NIS and Fluc (A7r5-NL cells). Functional assessment was performed by radioiodine uptake assay, luciferase assay and confocal microscopy. After exposure to lentivirus-HKII-shRNA, the 18F-FDG uptake test and HK activity assay were performed. The effects of combination therapy with 131I and lentivirus-HKII-shRNA on VSMCs were assessed with an in vitro clonogenic assay. In vivo bioluminescence and nuclear imaging were undertaken using a xenografted mo... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652108 Wed, 28 Sep 2011 04:00:00 +0100 5652108 http://www.medworm.com/index.php?rid=5652105&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001892%2Fabstract%3Frss%3Dyes Conclusion: The biological evaluations demonstrated the feasibility of using N-methylated C-6-substituted pyrimidine derivative N-Me-[18F]FHBT as a PET radiotracer for monitoring HSV1-TK expression in vivo. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652105 Wed, 28 Sep 2011 04:00:00 +0100 5652105 http://www.medworm.com/index.php?rid=5652103&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001867%2Fabstract%3Frss%3Dyes Conclusion: MRI was superior in the detection of all organ tumors compared to microCT and PET. [18F]-DOPA had overall better sensitivity than [18F]-DA for the detection of metastases. Subcutaneous tumors were localized only with [18F]-DOPA, a finding that may reflect differences in expression of VMAT1 and VMAT2, perhaps similar to some patients with pheochromocytoma where [18F]-DOPA provides better visualization of lesions than [18F]-DA. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652103 Wed, 28 Sep 2011 04:00:00 +0100 5652103 http://www.medworm.com/index.php?rid=5652101&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001879%2Fabstract%3Frss%3Dyes Conclusion: Quantitative PET using [11C]FTIMD with ultra-high specific activity can contribute to the detection of small changes in I2R expression in the brain. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5652101 Wed, 28 Sep 2011 04:00:00 +0100 5652101 http://www.medworm.com/index.php?rid=5563474&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001843%2Fabstract%3Frss%3Dyes This study clearly demonstrates that cell-free protein production system combined with positron emitter-labeled amino acid holds great promise as a novel approach to prepare radiolabeled proteins and peptides for PET imaging. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563474 Wed, 28 Sep 2011 04:00:00 +0100 5563474 http://www.medworm.com/index.php?rid=5563471&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001600%2Fabstract%3Frss%3Dyes Conclusions: Log P should not be relied upon as a predictor of blood-brain barrier penetration during brain radiotracer discovery. HPLC measurements of permeability, %PPB and membrane interactions may be potentially useful in predicting in vivo performance and hence allow evaluation and ranking of compound libraries for the selection of lead radiotracer candidates at early stages of radiotracer discovery. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563471 Wed, 28 Sep 2011 04:00:00 +0100 5563471 http://www.medworm.com/index.php?rid=5563470&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001582%2Fabstract%3Frss%3Dyes Conclusions: These results demonstrate the bivalent character of laniquidar, acting as a substrate at low doses and as a blocking agent for P-glycoprotein transport in the brain at higher doses. In comparison, no difference was observed in [11C]-dLop uptake between carrier- and no-carrier-added formulations, which confirms that desmethyl-loperamide is a substrate of P-glycoprotein at the blood–brain barrier. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563470 Wed, 28 Sep 2011 04:00:00 +0100 5563470 http://www.medworm.com/index.php?rid=5563469&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001570%2Fabstract%3Frss%3Dyes Conclusions: Total uptake of anti-[14C]FACBC by PCa cells correlates with the expression level of system ASC in PCa cells. Furthermore, LAT1 is an important transport system for anti-[14C]FACBC uptake, especially in an acidic environment, such as the intra-tumoural environment. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563469 Wed, 28 Sep 2011 04:00:00 +0100 5563469 http://www.medworm.com/index.php?rid=5563468&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001557%2Fabstract%3Frss%3Dyes Conclusion: The weaker noncovalent biotin–streptavidin bond may be essential for adequate delivery of the radiolabeled antisense oligomer to the nucleus of tumor cells. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563468 Wed, 28 Sep 2011 04:00:00 +0100 5563468 http://www.medworm.com/index.php?rid=5563465&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001569%2Fabstract%3Frss%3Dyes Conclusions: These data indicate that HS expressed in amyloid deposits has unique qualities that can be distinguished from HS in normal tissues. A scFv specific for rare hypersulfated HS was used to selectively image AA amyloid in mice with minimal retention in normal tissue. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563465 Wed, 28 Sep 2011 04:00:00 +0100 5563465 http://www.medworm.com/index.php?rid=5563462&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001594%2Fabstract%3Frss%3Dyes Abstract: The biodistribution, pharmacokinetics, dosimetry and comparative therapeutic efficacy of intravenously administrated 188Re-N,N-bis(2-mercaptoethyl)-N′,N′-diethylethylenediamine (BMEDA)-labeled pegylated liposome (188Re-liposome) and 5-FU were investigated in a CT26-luc lung-metastatic model. After intravenous administration of 188Re-liposome, tumor accumulation from the radioactivity was observed. Levels of radioactivity in tumors were maintained at steady levels (from 5.40 to 5.67 %ID/g) after 4 to 24 h. In pharmacokinetics, the AUC(0→∞), MRT(0→∞) and Cl of 188Re-liposome in blood via intravenous route were 998 h %ID/ml, 28.7 h and 0.1 ml/h, respectively. The total excreted fractions of feces and urine were 0.61 and 0.26, respectively. Absorbed doses for 188Re-liposo... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563462 Wed, 28 Sep 2011 04:00:00 +0100 5563462 http://www.medworm.com/index.php?rid=5563461&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001533%2Fabstract%3Frss%3Dyes Conclusions: These results suggest that D2C7 warrants further evaluation for the development of MAb-based therapeutics against cancers expressing EGFRwt and EGFRvIII. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563461 Wed, 28 Sep 2011 04:00:00 +0100 5563461 http://www.medworm.com/index.php?rid=5563460&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001624%2Fabstract%3Frss%3Dyes Conclusions: Micrometastatic growth of an ovarian cancer cell line was reduced in nude mice after treatment with 213Bi-MX35or 211At-MX35. Treatment with 211At-MX35 provided a non-significantly better result for the chosen activity levels. The radiolabeled MX35 did not accumulate to a high extent in the investigated organs. No considerable signs of toxicity were observed. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563460 Wed, 28 Sep 2011 04:00:00 +0100 5563460 http://www.medworm.com/index.php?rid=5563459&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001545%2Fabstract%3Frss%3Dyes Conclusions: 177Lu-h-R3 should be considered for further evaluations as a potential radiopharmaceutical for RIT of tumors overexpressing EGFR. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563459 Wed, 28 Sep 2011 04:00:00 +0100 5563459 http://www.medworm.com/index.php?rid=5563466&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001612%2Fabstract%3Frss%3Dyes Conclusions: The results of this preliminary study show that the irreversible antagonist [18F]3 may represent a novel strategy for imaging PPARγ in vivo with PET. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563466 Mon, 12 Sep 2011 04:00:00 +0100 5563466 http://www.medworm.com/index.php?rid=5470923&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001478%2Fabstract%3Frss%3Dyes The Molecular Imaging and Contrast Agents Database (MICAD; http://www.micad.nih.gov) is mandated to provide freely accessible online information regarding molecular imaging probes and contrast agents (called tracer, probe or agent from here on) that are under development, in preclinical or clinical evaluation, or commercially available for clinical application . The primary aim of MICAD is to promote the discovery, development and application of molecular imaging in biology, drug discovery and the clinical sciences. For inclusion in MICAD, the primary consideration is that a molecular imaging probe should have in vivo animal or human studies published in peer-reviewed journals available on the PubMed database. A comprehensive search on PubMed showed there were ∼4500 imaging and contrast ... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470923 Mon, 22 Aug 2011 04:00:00 +0100 5470923 http://www.medworm.com/index.php?rid=5563475&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001491%2Fabstract%3Frss%3Dyes Conclusion: It was detected in in vitro and in vivo studies that the human erythrocyte GR enzyme is inhibited due to the radiation effect of 201Tl solution. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563475 Wed, 10 Aug 2011 04:00:00 +0100 5563475 http://www.medworm.com/index.php?rid=5563467&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS096980511100148X%2Fabstract%3Frss%3Dyes Conclusion: [11C]Metrazoline may be a more useful PET probe than [11C]FTIMD for imaging of I2Rs in peripheral tissues. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563467 Wed, 10 Aug 2011 04:00:00 +0100 5563467 http://www.medworm.com/index.php?rid=5563463&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001508%2Fabstract%3Frss%3Dyes Conclusion: Our results showed that the blood clearance and metabolism were too rapid to obtain a reproducible input function after bolus injection. The equilibrium distribution ratios did not lead to precise biochemical parameters, but the constant infusion was more suitable in that distribution ratios between tissue and plasma were statistically more precise. Constant infusion is the better approach for studying [18F]FP-TZTP by small animal imaging. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5563463 Wed, 10 Aug 2011 04:00:00 +0100 5563463 http://www.medworm.com/index.php?rid=5470936&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001235%2Fabstract%3Frss%3Dyes We report here the development of 3-(2-(S)-azetidinylmethoxy)-5-(3′-fluoropropyl)pyridine (nifzetidine) as a new putative high-affinity antagonist for nicotinic α4β2 receptors. Nifzetidine in rat brain homogenate assays containing α4β2 sites labeled with 3H-cytisine exhibited a binding affinity: Ki=0.67 nM. The fluorine-18 analog, 3-(2-(S)-azetidinylmethoxy)-5-(3′-18F-fluoropropyl)pyridine (18F-nifzetidine), was synthesized in 20%–40% yield, and apparent specific activity was estimated to be above 2 Ci/μmol. Rat brain slices indicated selective binding of 18F-nifzetidine to thalamus, subiculum, striata, cortex and other regions consistent with α4β2 receptor distribution. This selective binding was displaced >85% by 150 μM nicotine. Positron emission tomography (PET) imaging s... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470936 Wed, 10 Aug 2011 04:00:00 +0100 5470936 http://www.medworm.com/index.php?rid=5470935&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001284%2Fabstract%3Frss%3Dyes Conclusions: Early distribution of BMSCs in traumatic brain disease could be monitored by 99mTc-labeling, which does not induce cellular death. However, our data showed that the amount of migrated 99mTc-BMSCs was not enough to be demonstrated by clinical gamma camera. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470935 Wed, 10 Aug 2011 04:00:00 +0100 5470935 http://www.medworm.com/index.php?rid=5470934&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001223%2Fabstract%3Frss%3Dyes Abstract: Recent advances in positron emission tomography (PET)/computed tomography have fueled the development of new PET-isotope-based agents for myocardial perfusion imaging. 68Ga, a generator-produced PET isotope, is an attractive radionuclide for developing a 68Ga-based cardiac imaging agent. We have synthesized seven new chelate systems based on our previously reported 1,2-[{6-(carboxylato-)pyridin-2-yl}methylamino]ethane (H2dedpa) scaffold. These ligands form lipophilic, cationic complexes upon coordination of 67/68Ga(III) under mild, direct labeling conditions within 10 min at room temperature. The corresponding cold complexes were also synthesized, and the solid-state structure of one of the complexes, [Ga(19)][ClO4], was determined. All compounds were investigated for in vitro st... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470934 Wed, 10 Aug 2011 04:00:00 +0100 5470934 http://www.medworm.com/index.php?rid=5470932&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001296%2Fabstract%3Frss%3Dyes Conclusion: The scanning time of 90–100 min for 18F-AV-133 is considered as the optimal time window for summed uptake measurements in terms of SUVRs' correlation to DVRs, differential power, stability and clinical feasibility across and between NC and PD patients. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470932 Wed, 10 Aug 2011 04:00:00 +0100 5470932 http://www.medworm.com/index.php?rid=5470930&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001259%2Fabstract%3Frss%3Dyes Conclusion: The method requires no liquid–liquid extraction, solvent evaporation or distillation capabilities and can be readily adapted to existing radiosynthesis modules. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470930 Wed, 10 Aug 2011 04:00:00 +0100 5470930 http://www.medworm.com/index.php?rid=5470924&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS096980511100117X%2Fabstract%3Frss%3Dyes In this study, we devise a method for determining receptor occupancy of the mass dose of the radioligand itself and the in vivo affinity.Methods: The approach was used for [11C]SB207145, a new PET radioligand for imaging the cerebral 5-HT4 receptors in humans. Test–retest PET studies with varying specific activities of [11C]SB207145 were conducted in seven healthy subjects, and the output parameter regional BPND was modeled. Individual occupancy plots were first computed to estimate the mass dose that saturates 50% of receptors (ID50), and subsequently, the maximal mass dose that can be injected (arbitrarily set at an occupancy (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470924 Wed, 10 Aug 2011 04:00:00 +0100 5470924 http://www.medworm.com/index.php?rid=5307270&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001120%2Fabstract%3Frss%3Dyes Conclusions: Reduced cardiac [3H]CGP12177 specific binding in the presence of sustained hyperglycemia corresponds to a decrease in relative β1-AR expression. These data indirectly support the use of [11C]CGP12177 for assessment of cardiac dysfunction in diabetes. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307270 Wed, 10 Aug 2011 04:00:00 +0100 5307270 http://www.medworm.com/index.php?rid=5307268&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001077%2Fabstract%3Frss%3Dyes Conclusion: H3MN-16ET is a suitable tetradentate ligand for 188Re labeling. From the animal data, we suggest that 188Re-MN-16ET/Lipiodol has the potential to be a therapeutic radiopharmaceutical for hepatoma treatment. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307268 Wed, 10 Aug 2011 04:00:00 +0100 5307268 http://www.medworm.com/index.php?rid=5134760&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001685%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134760 Sun, 31 Jul 2011 23:00:00 +0100 5134760 http://www.medworm.com/index.php?rid=5134741&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001648%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134741 Sun, 31 Jul 2011 23:00:00 +0100 5134741 http://www.medworm.com/index.php?rid=5134746&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000436%2Fabstract%3Frss%3Dyes In this study, we developed a new radiosynthesis method of 2-deoxy-2-[18F]fluoroacetamido-d-glucopyranose ([18F]FAG) by applying microwave irradiation and demonstrated that [18F]FAG could be a potential radiopharmaceutical to distinguish bacterial infection from nonbacterial inflammation.Methods: 1,3,4,6-Tetra-O-acetyl-2-deoxy-2-bromoacetamido-d-glucopyranose was used as precursor, and labeling was performed under microwave irradiation conditions followed by alkaline hydrolysis and high-performance liquid chromatography (HPLC) purification. In vitro uptake of [18F]FAG by Escherichia coli was performed. Tissue biodistribution of [18F]FAG was performed in mice. Moreover, PET imaging acquisition of E. coli infection and nonbacterial inflammation models was performed in rats. Tissue radiotrace... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134746 Thu, 14 Jul 2011 23:00:00 +0100 5134746 http://www.medworm.com/index.php?rid=5470929&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001260%2Fabstract%3Frss%3Dyes Conclusion: Low levels of [18F]fluoride in biological samples can be detected and quantified using an ion-exchange cartridge and gamma counting. This methodology is simple, accurate and superior to the standard use of radio-HPLC on a C18 column for metabolite analysis, and it should be useful in pharmacokinetic modeling for animal imaging studies using an [18F]-labeled radiotracer and PET. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470929 Mon, 11 Jul 2011 04:00:00 +0100 5470929 http://www.medworm.com/index.php?rid=5470938&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001181%2Fabstract%3Frss%3Dyes Abstract: Introduction: Alterations of dopamine in striatal presynaptic terminals play an important role in the hypoxic–ischemic (HI) brain injury. Quantification of DAT levels in the presynaptic site using 11C-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane (11C-CFT) with positron emission tomography (PET) was applied in studies for Parkinson's disease. The current study investigated the changes in striatal DAT following HI brain injury in newborn piglets using 11C-CFT PET.Methods: Newborn piglets were subjected to occlusion of bilateral common carotid arteries for 30 min and simultaneous peripheral hypoxia. Brain DAT imaging was performed using PET/CT with 11C-CFT as the probe in each group (including the control group and HI insult groups). Brain tissues were collected for DAT immunohisto... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470938 Fri, 08 Jul 2011 04:00:00 +0100 5470938 http://www.medworm.com/index.php?rid=5470937&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001156%2Fabstract%3Frss%3Dyes Conclusions: [18F]MK-3328 was identified as a promising PET tracer for in vivo quantification of amyloid plaques, and further evaluation in humans is warranted. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470937 Fri, 08 Jul 2011 04:00:00 +0100 5470937 http://www.medworm.com/index.php?rid=5470933&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001211%2Fabstract%3Frss%3Dyes Conclusions: This study demonstrated the feasibility of the 3D quantitation of rCBF in mice using a high-resolution pinhole SPECT system and 123I-IMP. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470933 Fri, 08 Jul 2011 04:00:00 +0100 5470933 http://www.medworm.com/index.php?rid=5470931&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001247%2Fabstract%3Frss%3Dyes Conclusions: An efficient and convenient GC method for the quality control of FCH has been developed and validated which meets all acceptance criteria in terms of linearity, specificity, precision, accuracy, LOD and LOQ. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470931 Fri, 08 Jul 2011 04:00:00 +0100 5470931 http://www.medworm.com/index.php?rid=5470928&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS096980511100120X%2Fabstract%3Frss%3Dyes Conclusion: This study demonstrates that the number of chelate conjugation and the injected dose are two important parameters to achieve high tumor and low non-target organ uptake of 111In-labeled MORAb-009. This study also suggests that the injected dose of mAb could be individualized based on the tumor size or the blood level of shed antigen in a patient to achieve the ideal tumor-to-organ radioactivity ratios. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470928 Fri, 08 Jul 2011 04:00:00 +0100 5470928 http://www.medworm.com/index.php?rid=5470927&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001272%2Fabstract%3Frss%3Dyes Conclusion: A convenient means to radiolabel and purify MBs was developed and the distribution of the labeled products determined. The result is a platform which can be used to assess the pharmacokinetics and fate of novel MB constructs both regionally using US and throughout the entire subject in a quantitative manner by employing small animal SPECT and tissue counting. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470927 Fri, 08 Jul 2011 04:00:00 +0100 5470927 http://www.medworm.com/index.php?rid=5470926&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001193%2Fabstract%3Frss%3Dyes Conclusion: A detailed method for the 57Co ligand to antibody test is described that allows a discrete value to be obtained. The assay was validated as fit for purpose against target values of coefficient of variation (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470926 Fri, 08 Jul 2011 04:00:00 +0100 5470926 http://www.medworm.com/index.php?rid=5307267&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001090%2Fabstract%3Frss%3Dyes Conclusion: Anti-2-[18F]FACPC-1 showed low background uptake in the brain, thoracic and abdominal cavities of humans, suggesting a possible use for detecting malignant tissues in these regions. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307267 Fri, 08 Jul 2011 04:00:00 +0100 5307267 http://www.medworm.com/index.php?rid=5307255&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001119%2Fabstract%3Frss%3Dyes Conclusion: The cis-labeled [18F]mefway tracer has low specific binding throughout the 5-HT1A regions of the brain compared to trans-[18F]mefway, suggesting that the target-to-background binding of cis-[18F]mefway may limit its use for in vivo assessment of 5-HT1A binding. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307255 Fri, 08 Jul 2011 04:00:00 +0100 5307255 http://www.medworm.com/index.php?rid=5134742&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005202%2Fabstract%3Frss%3Dyes “It is not the strongest of the species that survive, nor the most intelligent, but the one most responsive to change.” Charles Darwin . In 2001, Weissleder and Mahmood put forth this definition for Molecular Imaging: In contradistinction to classical (mostly anatomical) diagnostic imaging, it (molecular imaging) sets forth to probe the molecular abnormalities that are the basis of disease rather than to image the end effects of these molecular alterations. This brought into focus the contrast between what Nuclear Medicine had as a primary goal and what Radiology had as a primary goal, although functional studies with magnetic resonance imaging were being introduced at the time. This combination of strengths championed by Weissleder and Mahmood are illustrated by the proliferation of ... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134742 Thu, 07 Jul 2011 23:00:00 +0100 5134742 http://www.medworm.com/index.php?rid=4979448&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001351%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979448 Wed, 29 Jun 2011 23:52:34 +0100 4979448 http://www.medworm.com/index.php?rid=4979429&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001314%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979429 Wed, 29 Jun 2011 23:52:26 +0100 4979429 http://www.medworm.com/index.php?rid=5470925&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001168%2Fabstract%3Frss%3Dyes Conclusions: Radiolabeled ABY-025 Affibody molecule provides higher contrast in imaging of HER2-expressing PC xenografts than radiolabeled trastuzumab. Residualizing radiometal label for ABY-025 provides better contrast in imaging of HER2-expressing PC xenografts than nonresidualizing radiohalogen. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5470925 Thu, 23 Jun 2011 04:00:00 +0100 5470925 http://www.medworm.com/index.php?rid=5307266&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001089%2Fabstract%3Frss%3Dyes Conclusions: [18F]AV-133, in addition to a high-affinity VMAT2 binding site, binds with low affinity (but high capacity) to sigma components that are present in the rat pancreas. Identification of the cause of background binding of [18F]AV-133 to rat pancreatic tissue may lead to improved methods for quantification. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307266 Thu, 23 Jun 2011 04:00:00 +0100 5307266 http://www.medworm.com/index.php?rid=5307265&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001065%2Fabstract%3Frss%3Dyes Abstract: In an attempt to visualize folate receptors that overexpress on many cancers, [18F]-fluorobenzene and pyridinecarbohydrazide-folate/methotrexate conjugates ([18F]-1, [18F]-2-folates and [18F]-8, [18F]-9-MTXs) were synthesized by the nucleophilic displacement reactions using ethyl-trimethylammonium-benzoate and pyridinecarboxylate precursors. The intermediates ethyl [18F]-fluorinated benzene and pyridine esters were reacted with hydrazine to produce the [18F]-fluorobenzene and pyridinecarbohydrazides, followed by coupling with N-hydroxysuccinimide-folate/MTX. Radiochemical yields were greater than 80% (decay corrected), with total synthesis time of less than 45 min. Radiochemical purities were always greater than 97% without high-performance liquid chromatography purification. The... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307265 Thu, 23 Jun 2011 04:00:00 +0100 5307265 http://www.medworm.com/index.php?rid=5307262&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001144%2Fabstract%3Frss%3Dyes Conclusion: Our findings suggested that the cytidine analogue 18F-FIAC is a new potential PET probe for the imaging of HSV1-tk gene expression. 18F-FIAC may be regarded as the prodrug of 18F-FIAU in vivo. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307262 Thu, 23 Jun 2011 04:00:00 +0100 5307262 http://www.medworm.com/index.php?rid=5307261&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001132%2Fabstract%3Frss%3Dyes Conclusions: Initial rates of FLT uptake were a function of both concentrative and equilibrative transporters. TK1 activity was an absolute requirement for the accumulation of FLT. Retention was dependent on nucleoside/nucleotide efflux and retrograde metabolism of FLT nucleotides. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307261 Thu, 23 Jun 2011 04:00:00 +0100 5307261 http://www.medworm.com/index.php?rid=5307259&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001107%2Fabstract%3Frss%3Dyes Conclusion: The infusion of MSCs labeled with 111In-oxine through a peripheral vein is safe in cirrhosis. Cell labeling with 111In-oxine is a suitable method for tracking MSC distribution after infusion. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307259 Thu, 23 Jun 2011 04:00:00 +0100 5307259 http://www.medworm.com/index.php?rid=5307256&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111001053%2Fabstract%3Frss%3Dyes Abstract: Introduction: Imaging monoamine oxidase B (MAO-B) in the central nervous system with PET is an important goal for psychiatric studies. We here report an improved and automated radiosynthesis of N-(6-[18F]-fluorohexyl)-N-methylpropargylamine ([18F]FHMP; [18F]-1), as well as the radiosynthesis of two new promising candidates for imaging cerebral MAO-B, namely, carbon-11-labeled 3-(4-[11C]-methoxyphenyl)-6-methyl-2H-1-benzopyran-2-one ([11C]-2) and N-((1H-pyrrol-2-yl)methyl)-N-[11C]-methyl-1-phenylmethanamine ([11C]-3).Methods: Fluorine-18-labeled 1 was prepared via a tosyloxy precursor in 29%±5% uncorrected radiochemical yield, relative to [18F]-fluoride. Both carbon-11-labeled compounds were prepared with [11C]CH3I using the “LOOP” method in 11% and 18% uncorrected radiochemi... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307256 Mon, 20 Jun 2011 04:00:00 +0100 5307256 http://www.medworm.com/index.php?rid=5134747&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS096980511100045X%2Fabstract%3Frss%3Dyes Conclusion: In a porcine model of myocardial infarction after 45 min of ischemia, MIBI administered 120 min after reperfusion delineates AAR. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134747 Thu, 19 May 2011 23:00:00 +0100 5134747 http://www.medworm.com/index.php?rid=5307260&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000576%2Fabstract%3Frss%3Dyes Conclusions: Calculation of FES SUV, possibly adjusted for LBM, should be sufficient to assess FES uptake for the purpose of inferring ER expression. Pre-menopausal estradiol levels do not appear to interfere with FES uptake. The availability and binding properties of SHBG influence FES uptake and should be measured. Specific activity did not have a clear influence on FES uptake, except perhaps at higher injected mass per kilogram. These results suggest that FES imaging protocols may be simplified without sacrificing the validity of the results. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307260 Fri, 06 May 2011 04:00:00 +0100 5307260 http://www.medworm.com/index.php?rid=5134743&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000370%2Fabstract%3Frss%3Dyes Abstract: Purpose: Unique uptake and retention mechanisms of positron emission tomography (PET) hypoxia tracers make in vivo comparison between them challenging. Differences in imaged uptake of two common hypoxia radiotracers, [61Cu]Cu-ATSM and [18F]FMISO, were characterized via computational modeling to address these challenges.Materials and Methods: An electrochemical formalism describing bioreductive retention mechanisms of these tracers under steady-state conditions was adopted to relate time-averaged activity concentration to tissue partial oxygen tension (PO2), a common metric of hypoxia. Chemical equilibrium constants of product concentration to reactant concentration ratios were determined from free energy changes and reduction potentials of pertinent reactions reported in the lite... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134743 Thu, 05 May 2011 23:00:00 +0100 5134743 http://www.medworm.com/index.php?rid=4772949&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000849%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772949 Sat, 30 Apr 2011 23:00:00 +0100 4772949 http://www.medworm.com/index.php?rid=4772940&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004890%2Fabstract%3Frss%3Dyes Abstract: Acetylcholinesterase (AChE) has been an important cholinergic factor for the diagnosis of Alzheimer's disease (AD), because of reduced AChE activity in the postmortem brains of AD patients. We previously developed 5,7-dihydro-3-(2-(1-(2-[18F]fluorobenzyl)-4-piperidinyl)ethyl)-6H-pyrrolo(3,2,f)-1,2-benzisoxazol-6-one (2-[18F]fluoro-CP-118,954) for in vivo studies of AChE in mice. In the present study, we automated the synthesis of 2-[18F]fluoro-CP-118,954 for the routine use and evaluated the radioligand by microPET and ex vivo Cerenkov luminescence imaging of mouse AChE. 4-[18F]Fluoro-donepezil, another AChE inhibitor, was used for comparison. Automated syntheses of 2-[18F]fluoro-CP-118,954 and 4-[18F]fluoro-donepezil resulted in high radiochemical yields (25–33% and 30–40%) ... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772940 Sat, 30 Apr 2011 23:00:00 +0100 4772940 http://www.medworm.com/index.php?rid=4772930&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000801%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772930 Sat, 30 Apr 2011 23:00:00 +0100 4772930 http://www.medworm.com/index.php?rid=5307258&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000552%2Fabstract%3Frss%3Dyes Conclusions: Consistent with biodistribution studies, uptake of [18F]-scyllo-inositol was successfully visualized by PET imaging in human BC and glioma xenografts, with lower accumulation in inflammatory tissue than [18F]-FDG. The tumour-to-brain ratio of [18F]-scyllo-inositol was also significantly higher than that of [18F]-FDG for visualizing intracranial glioma xenografts in NOD SCID mice, giving a better contrast.Graphical Abstract: (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307258 Fri, 29 Apr 2011 04:00:00 +0100 5307258 http://www.medworm.com/index.php?rid=5134758&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000473%2Fabstract%3Frss%3Dyes Conclusion: These findings suggest that the cyclotron production of 99mTc may be a feasible alternative to the current reactor-based production strategy. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134758 Thu, 28 Apr 2011 23:00:00 +0100 5134758 http://www.medworm.com/index.php?rid=5134752&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000461%2Fabstract%3Frss%3Dyes Conclusion: The results showed that one may consider 177Lu-DOTA–PR81 as a potential radiopharmaceutical for therapy of human breast cancer, which needs further investigations. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134752 Thu, 28 Apr 2011 23:00:00 +0100 5134752 http://www.medworm.com/index.php?rid=5134750&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000400%2Fabstract%3Frss%3Dyes Conclusion: Compared to the SUV, the autoradiographic Ki values are advantageous for various reasons. First, they are much less dependent on the time of acquisition than the SUV. Second, their calculation does not require the knowledge of the body weight or the injected activity. Furthermore, the values are comparable to the ones obtained with the widely accepted Patlak method. The method can be easily implemented in a clinical setting, as it uses only one static scan. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134750 Thu, 28 Apr 2011 23:00:00 +0100 5134750 http://www.medworm.com/index.php?rid=5307271&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000564%2Fabstract%3Frss%3Dyes Conclusion: These studies may provide a novel treatment strategy for overcoming resistance to conventional therapy in multiple myeloma. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307271 Fri, 22 Apr 2011 04:00:00 +0100 5307271 http://www.medworm.com/index.php?rid=5307269&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000540%2Fabstract%3Frss%3Dyes Abstract: Introduction: Differentiated thyroid carcinoma (DTC) usually has a high iodine uptake. However, dedifferentiation of DTC with decreased or no radioiodine (131I) uptake is observed in clinical practice, with poor prognosis. The aim of this study was to investigate the effects of 131I radiation on radioiodine uptake (RAIU) and the expression of thyroid-specific molecules.Methods: FTC-133 cells were treated with 131I, the dosage dictated by methylthiazol tetrazolium test results and preliminary experiments. The experimental cell group was incubated with 131I for 48 h and then cultured for 3 months in 131I-free medium. The control group was set without 131I. Primary cells were defined as the blank group. Following treatment, RAIU was measured with a gamma counter as the counts/cell n... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307269 Fri, 22 Apr 2011 04:00:00 +0100 5307269 http://www.medworm.com/index.php?rid=5307264&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000527%2Fabstract%3Frss%3Dyes Conclusion: We have developed a novel 68Ga-radiolabeled bone-seeking agent. This [68Ga]NOTA-BP complex was found to have a high bone affinity and rapid blood clearance, and may thus prove to be useful as a bone-seeking agent for clinical PET. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307264 Fri, 22 Apr 2011 04:00:00 +0100 5307264 http://www.medworm.com/index.php?rid=5307263&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000515%2Fabstract%3Frss%3Dyes Abstract: Introduction: Radiolabeled bombesin (BN) conjugates are promising radiotracers for imaging and therapy of breast and prostate tumors in which BN2/gastrin-releasing peptide (GRP) receptors are overexpressed. However, the low in vivo stability of BN conjugates may limit their clinical application. In an attempt to improve their pharmacokinetics and counteract their rapid enzymatic degradation, we prepared a series of polyethylene glycol (PEG)-ylated BN(7-14) analogues for radiolabeling with 99mTc(CO)3 and evaluated them in vitro and in vivo.Methods: Derivatization of a stabilized (NαHis)Ac-BN(7-14)[Cha13,Nle14] analogue with linear PEG molecules of various sizes [5 kDa (PEG5), 10 kDa (PEG10) and 20 kDa (PEG20)] was performed by PEGylation of the ɛ-amino group of a β3hLys-βAla-�... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307263 Fri, 22 Apr 2011 04:00:00 +0100 5307263 http://www.medworm.com/index.php?rid=5307257&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000539%2Fabstract%3Frss%3Dyes Abstract: Introduction: To clarify the role of oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson's disease (PD) in living patients, positron emission tomography (PET) with [62Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([62Cu]ATSM) was applied to functional imaging of oxidative stress mainly due to mitochondrial dysfunction in the striata of patients with PD.Methods: Fifteen PD patients who presented with lateral dominant symptoms at onset and six healthy controls underwent [62Cu]ATSM PET. Dynamic PET data acquisition was performed, and standardized uptake values (SUVs) were obtained from the delayed phase of dynamic data by means of region of interest analysis. The striatum-to-cerebellum SUV ratio (S/C ratio) was calculated from the SUV in all subjects of the... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5307257 Fri, 22 Apr 2011 04:00:00 +0100 5307257 http://www.medworm.com/index.php?rid=5134756&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000503%2Fabstract%3Frss%3Dyes Conclusion: SPECT imaging of mesothelin expressing tumors was demonstrated successfully. Our findings indicate that the antimesothelin antibody mAbMB has the potential to be developed into a diagnostic agent for imaging mesothelin-expressing cancers. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134756 Thu, 21 Apr 2011 23:00:00 +0100 5134756 http://www.medworm.com/index.php?rid=5134754&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000394%2Fabstract%3Frss%3Dyes Conclusions: These results emphasize the fact that even a small chemical modification, i.e. iodination, might deeply modify the pharmacological profile of a compound and support observations that the C-terminal tail of human AM plays an important role in the AM receptor binding process. Consequently, incorporation of a radionuclide to produce an AM-based nuclear medicine agent should privilege the N-terminus of the molecule. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134754 Thu, 21 Apr 2011 23:00:00 +0100 5134754 http://www.medworm.com/index.php?rid=5134753&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000369%2Fabstract%3Frss%3Dyes Conclusions: [77Br]BAMT showed high levels of tumor accumulation, and [76Br]BAMT enabled clear visualization of the tumor by PET imaging. Although an improvement in stability is still needed, 76Br-labeled FAMT analogs could potentially serve as PET tracers for the imaging of malignant tumors. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134753 Thu, 21 Apr 2011 23:00:00 +0100 5134753 http://www.medworm.com/index.php?rid=5134751&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000412%2Fabstract%3Frss%3Dyes Conclusion: In this study, the discrepancy in quantitating organ radioactivity accumulations between noninvasive imaging and necropsy was primarily due to blood pool radioactivity contributing to the in vivo images. The discrepancy may be minimized by subtracting an estimate of this contribution. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134751 Thu, 21 Apr 2011 23:00:00 +0100 5134751 http://www.medworm.com/index.php?rid=5134748&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000485%2Fabstract%3Frss%3Dyes Conclusions: The present work shows the feasibility of quantitatively monitoring and evaluating cell trafficking and distribution following administration of [18F]FDG-labeled T-lymphoblasts. The protocol can potentially be transferred to the clinical setting with few modifications. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134748 Thu, 21 Apr 2011 23:00:00 +0100 5134748 http://www.medworm.com/index.php?rid=5134745&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000497%2Fabstract%3Frss%3Dyes This study was designed to 99mTc-radiolabel an IL-1ra and IL-18bp dual-domain cytokine ligand, IL-18bp-Fc-IL-1ra, for specific inflammation targeting.Methods: The 99mTc-IL-18bp-Fc-IL-1ra was obtained by direct labeling via 2-iminothiolane reduction. Competitive binding of 99mTc-labeled and unlabeled IL-18bp-Fc-IL-1ra to rat polymorphonuclear leukocytes was assessed in vitro. A mouse ear edema model was used to evaluate specific targeting properties of 99mTc-IL-18bp-Fc-IL1ra in vivo. The correlation between 99mTc-IL-18bp-Fc-IL-1ra uptake and 111In-labeled polymorphonuclear neutrophil infiltration was studied using ischemic–reperfused rat hearts.Results: Direct 99mTc-labeling yielded a stable dual-domain cytokine radioligand with radiochemical purity greater than 95% after gel filtration. ... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134745 Thu, 21 Apr 2011 23:00:00 +0100 5134745 http://www.medworm.com/index.php?rid=5134744&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000382%2Fabstract%3Frss%3Dyes Conclusions: We propose that [18F]-FMISO PET and multiparametric magnetic resonance imaging are pertinent complementary tools in the evaluation of the effects of an antiangiogenic treatment in glioma. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134744 Thu, 21 Apr 2011 23:00:00 +0100 5134744 http://www.medworm.com/index.php?rid=5134759&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000448%2Fabstract%3Frss%3Dyes Conclusions: We were able to produce 161Tb in n.c.a. form by irradiating highly enriched 160Gd targets; it can be obtained in the quantity and quality required for the preparation of 161Tb-labeled therapeutic agents. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134759 Wed, 20 Apr 2011 23:00:00 +0100 5134759 http://www.medworm.com/index.php?rid=4706638&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000655%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4706638 Thu, 31 Mar 2011 23:00:00 +0100 4706638 http://www.medworm.com/index.php?rid=4706637&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000333%2Fabstract%3Frss%3Dyes The contribution of Prof. Spreitzer for the article above was the participation in the planning of the project and the supervision of the precursor preparation. Additionally, the correct byline appears above. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4706637 Thu, 31 Mar 2011 23:00:00 +0100 4706637 http://www.medworm.com/index.php?rid=4706620&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000618%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4706620 Thu, 31 Mar 2011 23:00:00 +0100 4706620 http://www.medworm.com/index.php?rid=5134757&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000357%2Fabstract%3Frss%3Dyes Conclusion: Thus, increase of A2A receptor-mediated uptake of radioactive MRS5425 could be a superior molecular target for Parkinson's imaging. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134757 Wed, 30 Mar 2011 23:00:00 +0100 5134757 http://www.medworm.com/index.php?rid=5134755&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000424%2Fabstract%3Frss%3Dyes Conclusion: We demonstrated that [11C]MP-10 possesses good characteristics for the in vivo quantification of the PDE10A in the brain by PET. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=5134755 Wed, 30 Mar 2011 23:00:00 +0100 5134755 http://www.medworm.com/index.php?rid=4979446&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000321%2Fabstract%3Frss%3Dyes Conclusions: This study highlights the versatility of using the His derivative linker for 99mTc tagging of a variety of peptides. It also demonstrates greater peptide localization and thereby bioavailability of therapeutic peptides to inflamed joints following specific conjugation to homing peptides. The ability to localize peptide/drugs to inflamed synovium has important therapeutic implications. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979446 Wed, 30 Mar 2011 23:00:00 +0100 4979446 http://www.medworm.com/index.php?rid=4979445&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005147%2Fabstract%3Frss%3Dyes Conclusion: Our data reveal that [123I]altropane predicts the integrity of the striatal dopamine nerve terminals, but does not predict the integrity of the nigrostriatal system. [123I]altropane could be a useful marker to measure dopamine content in cell replacement therapies; however, it would not be able to evaluate outcomes for neuroprotective strategies. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979445 Wed, 30 Mar 2011 23:00:00 +0100 4979445 http://www.medworm.com/index.php?rid=4979437&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000047%2Fabstract%3Frss%3Dyes Conclusions: The improved radiosyntheses of [18F]FAU, [18F]FEAU, [18F]FFAU, [18F]FCAU, [18F]FBAU and [18F]FIAU have been achieved with reasonable yields and high purity using a multistep one-pot method. The synthetic time has been reduced, and the reaction procedures have been significantly simplified. The success of this approach may make PET tracers [18F]FAU, [18F]FEAU, [18F]FFAU, [18F]FCAU, [18F]FBAU and [18F]FIAU more accessible for preclinical and clinical research. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979437 Wed, 30 Mar 2011 23:00:00 +0100 4979437 http://www.medworm.com/index.php?rid=4979436&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS096980511100031X%2Fabstract%3Frss%3Dyes Conclusion: We present a radiosynthesis of FET where the usually used HPLC purification procedure has been substituted by a purification step based on standard cartridges. This method is useful for automatic modules without an expensive HPLC purification unit and for the routine production of FET. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979436 Wed, 30 Mar 2011 23:00:00 +0100 4979436 http://www.medworm.com/index.php?rid=4979434&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000308%2Fabstract%3Frss%3Dyes Conclusion: The described approach gives a proof of principle of the enhanced productivity obtainable using a microfluidic approach; in particular, the possibility to produce the reported tracers in a DOD fashion following a homogeneous synthetic and purification approach will foster further studies on the clinical evaluation of the best fluorocholine analogue for prostate cancer imaging without biasing for differences in radiochemical approach. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979434 Wed, 30 Mar 2011 23:00:00 +0100 4979434 http://www.medworm.com/index.php?rid=4979431&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000291%2Fabstract%3Frss%3Dyes Although bone seekers have been used for more than 30 years in nuclear medicine, the underlying mechanisms involved in their uptake into osseous tissue are still under discussion. Controversial hypotheses regarding these mechanisms range from simple chemisorption onto bone minerals with disputed binding to the organic collagen phase, overincorporation into the mineralisation process, to a combination of both mechanisms. Additionally, the involvement of the cellular fraction of bone tissue has been a matter of discussion. Recently, discussion has intensified on the involvement of osteoclasts in this uptake process. Comprehensible arguments that underline the contribution of osteoclasts originate from research on bisphosphonates (BPs) in antiresorptive therapy (e.g., in osteoporosis, Morbus ... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979431 Wed, 30 Mar 2011 23:00:00 +0100 4979431 http://www.medworm.com/index.php?rid=4979430&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005196%2Fabstract%3Frss%3Dyes Contributions from Matthias Friebe, Ph.D., of Bayer Healthcare, Peter Iveson, Ph.D., of General Electric, John Babich, Ph.D., of Molecular Insight Pharmaceuticals, Inc., Frederick Cope of Neoprobe Corporation and Roberto Pasquilini of IBA. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979430 Wed, 30 Mar 2011 23:00:00 +0100 4979430 http://www.medworm.com/index.php?rid=4979447&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005184%2Fabstract%3Frss%3Dyes Conclusion: We demonstrate that radiochemotherapy of hepatocarcinoma via lentiviral-mediated coexpression of NIS gene and HSV-TK gene leads to stronger killing effect than single treatment, and in vivo studies are needed to verify these findings. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979447 Mon, 07 Mar 2011 00:00:00 +0100 4979447 http://www.medworm.com/index.php?rid=4979444&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000035%2Fabstract%3Frss%3Dyes Conclusions: These data suggest that D3 selective conformationally-flexible benzamide analogs which contain a N-2-methoxyphenylpiperazine moiety are substrates for P-glycoprotein or other adenosine triphosphate (ATP)-binding cassette transporters expressed at the blood-brain barrier, and that PET radiotracers containing this pharmacophore may display low brain uptake in rodents due to the action of these efflux transporters. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979444 Mon, 07 Mar 2011 00:00:00 +0100 4979444 http://www.medworm.com/index.php?rid=4979443&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005238%2Fabstract%3Frss%3Dyes Abstract: Introduction: Use of folic acid radioconjugates for folate receptor (FR) targeting is a promising strategy for imaging purposes as well as for potential therapy of cancer and inflammatory diseases due to the frequent FR overexpression found on cancer cells and activated macrophages. Herein, we report on preclinical results using a novel DOTA-Bz-EDA-folate conjugate radiolabeled with [67Ga]-gallium.Methods: DOTA-Bz-EDA-folate was prepared by conjugation of ethylenediamine-(γ)-folate with 2-(p-isothiocyanobenzyl)-DOTA. Radiolabeling was carried out with 67GaCl3 according to standard procedures. Biodistribution studies of the tracer were performed in mice bearing FR-positive KB tumor xenografts. The effects on radiofolate biodistribution with coadministered renal uptake-blocking am... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979443 Mon, 07 Mar 2011 00:00:00 +0100 4979443 http://www.medworm.com/index.php?rid=4979442&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005226%2Fabstract%3Frss%3Dyes Conclusions: We demonstrated the increase of brain penetration of [11C]TPT by deficiency and inhibition of Pgp and BCRP functions using small-animal PET in mice. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979442 Mon, 07 Mar 2011 00:00:00 +0100 4979442 http://www.medworm.com/index.php?rid=4979441&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005172%2Fabstract%3Frss%3Dyes Conclusions: A 6-aminohexanoic linker between the DOTA chelator and N-terminus of synthetic ZHER2:342 had a measurable effect on affinity, cellular retention of radioactivity and blood clearance. The linker might be used for modulation of targeting properties of Affibody molecules. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979441 Mon, 07 Mar 2011 00:00:00 +0100 4979441 http://www.medworm.com/index.php?rid=4979440&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005160%2Fabstract%3Frss%3Dyes Conclusion: The significant non-tumor background uptake of [18F]-FESAHA presents a substantial obstacle to the use of the radiotracer as an HDAC expression imaging agent. The study at hand, however, does present a number of lessons critical to both the synthesis of hydroxamic acid containing PET radiotracers and imaging agents aimed at delineating HDAC expression. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979440 Mon, 07 Mar 2011 00:00:00 +0100 4979440 http://www.medworm.com/index.php?rid=4979439&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005214%2Fabstract%3Frss%3Dyes Conclusion: Despite the complexity of Zr coordination, the electrophoretic analyses provided detailed evidences of Zr charges either as salts or as complexes. This study also shows that weakly chelated, 89Zr is a bone seeker and has a strong affinity for phosphate. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979439 Mon, 07 Mar 2011 00:00:00 +0100 4979439 http://www.medworm.com/index.php?rid=4979438&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005159%2Fabstract%3Frss%3Dyes Conclusion: On the time scale typical of PET imaging studies radioactive metabolites of [18F]6FDG are negligible. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979438 Mon, 07 Mar 2011 00:00:00 +0100 4979438 http://www.medworm.com/index.php?rid=4979435&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000023%2Fabstract%3Frss%3Dyes Conclusion: The automated radiosynthesis provides high and reproducible yields suitable for routine clinical use. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979435 Mon, 07 Mar 2011 00:00:00 +0100 4979435 http://www.medworm.com/index.php?rid=4979433&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005123%2Fabstract%3Frss%3Dyes Conclusions: 67Ga-DOTA-Bn-SCN-HBP showed ideal biodistribution characteristics as a bone-imaging agent. These findings should provide useful information on the drug design of bone imaging agents for PET with 68Ga. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979433 Mon, 07 Mar 2011 00:00:00 +0100 4979433 http://www.medworm.com/index.php?rid=4979432&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005135%2Fabstract%3Frss%3Dyes Conclusions: 99mTc-IPrDP possesses excellent characteristics for the potential application as a novel bone scanning agent. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4979432 Mon, 07 Mar 2011 00:00:00 +0100 4979432 http://www.medworm.com/index.php?rid=4772946&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004919%2Fabstract%3Frss%3Dyes We describe new [18F]Fluoropropylcarbomethoxyiodophenyl-nor-tropane ([18F]FP-CIT) automatic preparation method by (1) using 2-methyl-2-butanol as [18F]fluorination solvent, (2) base amount control to minimize side reaction and (3) salt elution method to elute trapped [18F]fluoride. We developed manual synthesis procedures for automatic synthesis application. In this manual synthesis, we trapped [18F]F− on ion exchange cartridge and eluted with 0.2 M potassium methanesulfonate solution. We have [18F]fluorination at 100°C with 2-methyl-2-butanol as protic solvent for [18F]fluorination. After high-performance liquid chromatography analysis, we have 69.3±3.2% of [18F]F− incorporation ratio on the manual synthesis and applied these conditions to automatic preparation with GE TracerLab FX ... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772946 Mon, 07 Mar 2011 00:00:00 +0100 4772946 http://www.medworm.com/index.php?rid=4772934&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005111%2Fabstract%3Frss%3Dyes Conclusion: An increasing trend between 18FLT uptake and Ki67 mitotic index is seen in malignant tissue. Additional studies will determine whether 18FLT PET/CT is specific enough to distinguish between cancerous and noncancerous cells and to assess its role in ovarian carcinoma patient management. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772934 Mon, 07 Mar 2011 00:00:00 +0100 4772934 http://www.medworm.com/index.php?rid=4772931&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS096980511000510X%2Fabstract%3Frss%3Dyes Conclusions: These preclinical data convincingly demonstrated that [131I]IPA plus external beam photon radiotherapy is a safe and highly effective treatment for experimental gliomas, which may merit a clinical trial to ascertain its potential as a therapeutic approach in patients. As only a low [131I]IPA activity and a low RT dose were applied, further optimization strategies should be pursued experimentally, including application of higher radiation doses and conventional fractionated regimens or use of methods aiming to increase target doses and maximize dose effects. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772931 Mon, 07 Mar 2011 00:00:00 +0100 4772931 http://www.medworm.com/index.php?rid=4772937&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004828%2Fabstract%3Frss%3Dyes Conclusion: Our results indicate that, despite its rapid metabolism, [18F]FBA-FALGEA-NH2 binds preferentially to EGFRvIII in the tumours in vivo and is a promising lead for further development of EGFRvIII specific peptide radiopharmaceuticals. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772937 Wed, 02 Mar 2011 00:00:00 +0100 4772937 http://www.medworm.com/index.php?rid=4772947&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004841%2Fabstract%3Frss%3Dyes Conclusion: Our results indicated that an improved transgene expression of 131I-stimulated hNIS in U87 cells using a baculovirus vector containing the Egr1 promoter is possible, and the increased expression of hNIS is responsible for a higher 131I uptake. It might provide a reference for the existence of a positive feedback effect in 131I-promoted Bac-Egr1-hNIS expression in malignant glioma and is an interesting aspect of NIS-related studies. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772947 Tue, 08 Feb 2011 00:00:00 +0100 4772947 http://www.medworm.com/index.php?rid=4772944&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004774%2Fabstract%3Frss%3Dyes Abstract: Introduction: Most of the commercially available 68Ge/68Ga generator systems are not optimally designed for direct applications in a clinical context. We have developed a nano-zirconia based 68Ge/68Ga generator system for accessing 68Ga amenable for the preparation of radiopharmaceuticals.Methods: Nano-zirconia was synthesized by the in situ reaction of zirconyl chloride with ammonium hydroxide in alkaline medium. The physical characteristics of the material were studied by various analytical techniques. A 740 MBq (20 mCi) 68Ge/68Ga generator was developed using this sorbent and its performance was evaluated for a period of 1 year. The suitability of 68Ga for labeling biomolecules was ascertained by labeling DOTA-TATE with 68Ga.Results: The material synthesized was nanocrystallin... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772944 Tue, 08 Feb 2011 00:00:00 +0100 4772944 http://www.medworm.com/index.php?rid=4772942&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004865%2Fabstract%3Frss%3Dyes Conclusion: The modification of the coligands can significantly alter the pharmacokinetic properties of the corresponding 99mTc-HYNIC complexes. 99mTc (HYNIC-NHHN-FA)(tricine/TPPTS), 7 could be a promising radiotracer for FR imaging. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772942 Tue, 08 Feb 2011 00:00:00 +0100 4772942 http://www.medworm.com/index.php?rid=4772939&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004877%2Fabstract%3Frss%3Dyes Abstract: Introduction: The αVβ3 integrin is a well-known transmembrane receptor involved in tumor invasion, angiogenesis and metastasis. Our aim was to evaluate a novel positron emission tomography (PET) probe, 64Cu-cyclam-RAFT-c(-RGDfK-)4, for noninvasive visualization and quantification of αVβ3 integrin expression.Methods: RAFT-c(-RGDfK-)4, a tetrameric cyclic Arg-Gly-Asp (RGD)-based peptide, was conjugated with a bifunctional chelator, 1,4,8,11-tetraazacyclotetradecane (cyclam), radiolabeled with the positron emitter 64Cu and evaluated in vitro by cell binding and competitive inhibition assays and in vivo by biodistribution and receptor blocking studies, and PET imaging. The following cell lines, human embryonic kidney HEK293(β1) [αVβ3-negative] and HEK293(β3) [αVβ3-overexpre... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772939 Tue, 08 Feb 2011 00:00:00 +0100 4772939 http://www.medworm.com/index.php?rid=4772938&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004889%2Fabstract%3Frss%3Dyes Conclusions: [11C]SA1 has the most suitable profile among the three carbon-11-labelled GlyT-1 inhibitors. Lead optimization of [11C]SA1 structure will be required to achieve in vivo selective GlyT-1 imaging. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772938 Tue, 08 Feb 2011 00:00:00 +0100 4772938 http://www.medworm.com/index.php?rid=4772936&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004804%2Fabstract%3Frss%3Dyes Conclusions: In this research, two new fluorine-18 labeled 2-nitroimidazole derivatives, [18F]7 and [18F]8, both of which containing in vivo hydrolyzable group, were successfully prepared. Further biological evaluations are warranted to investigate their potential as PET radioligands for imaging tumor. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772936 Tue, 08 Feb 2011 00:00:00 +0100 4772936 http://www.medworm.com/index.php?rid=4772935&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004907%2Fabstract%3Frss%3Dyes Conclusions: The radiosynthesis of 123I-NKJ64 was achieved with good isolated radiochemical yield of 68% and a high specific activity of 1.8 Ci/μmol. TFA was found to be the most suitable deprotecting agent, since 2 M HCl generated a by-product that could not be fully separated from 123I-NKJ64 using the HPLC methodology investigated. This study highlights the importance of HPLC purification and accurate measurement of specific activity while developing new radiosynthesis methodologies. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772935 Tue, 08 Feb 2011 00:00:00 +0100 4772935 http://www.medworm.com/index.php?rid=4772933&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004853%2Fabstract%3Frss%3Dyes Conclusion: Commercially available Talose triflate is a suitable starting material for routine productions of FDGal. The presented radiosynthesis and quality control methods allow for the production of pure, no-carrier-added FDGal in sufficient amounts for clinical PET-investigations of the liver. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772933 Tue, 08 Feb 2011 00:00:00 +0100 4772933 http://www.medworm.com/index.php?rid=4772932&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS096980511000483X%2Fabstract%3Frss%3Dyes Conclusion: Based on the GLUT5 specific transport and phosphorylation by ketohexokinase, 6-[18F]FDF may represent a novel radiotracer for PET imaging of GLUT5 and ketohexokinase-expressing tumors. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772932 Tue, 08 Feb 2011 00:00:00 +0100 4772932 http://www.medworm.com/index.php?rid=4467796&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000102%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4467796 Tue, 01 Feb 2011 00:00:00 +0100 4467796 http://www.medworm.com/index.php?rid=4467777&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110005093%2Fabstract%3Frss%3Dyes The editorial board of Nuclear Medicine and Biology would like to wish you a belated Happy New Year and thank you for your support of the journal over the past year. To start this new year, we have altered the cover of Nuclear Medicine and Biology and the aims and scope to better reflect the goals of the journal. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4467777 Tue, 01 Feb 2011 00:00:00 +0100 4467777 http://www.medworm.com/index.php?rid=4467776&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805111000060%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4467776 Tue, 01 Feb 2011 00:00:00 +0100 4467776 http://www.medworm.com/index.php?rid=4467792&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004105%2Fabstract%3Frss%3Dyes Conclusions: Our studies demonstrate that as opposed to its behavior in human recombinant system, in rat brain tissue CUMI-101 behaves as a potent 5-HT1A receptor antagonist. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4467792 Mon, 03 Jan 2011 00:00:00 +0100 4467792 http://www.medworm.com/index.php?rid=4366210&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS096980511000497X%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4366210 Sat, 01 Jan 2011 00:00:00 +0100 4366210 http://www.medworm.com/index.php?rid=4366198&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110003896%2Fabstract%3Frss%3Dyes Conclusion: Rituximab could be directly and stably labeled with the matched pair 99mTc/188Re using the IsoLink technology under retention of the biological activity. Labeling kinetics and yields need further improvement for potential routine application in radioimmunodiagnosis and therapy. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4366198 Sat, 01 Jan 2011 00:00:00 +0100 4366198 http://www.medworm.com/index.php?rid=4366195&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004932%2Fabstract%3Frss%3Dyes (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4366195 Sat, 01 Jan 2011 00:00:00 +0100 4366195 http://www.medworm.com/index.php?rid=4772948&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004786%2Fabstract%3Frss%3Dyes Abstract: 18F-labeled sodium fluoride ([18F]NaF) is a useful bone imaging agent that has been demonstrated to be significantly more accurate than 99mTc-labeled methylene diphosphonate for the detection of both sclerotic and lytic lesions in various malignancies. A reliable anion-exchange HPLC method equipped with suppressed conductivity and radioactive detectors has been developed in order to analyze the content of NaF and radiochemical purity in [18F]NaF radiopharmaceuticals. The method described for fluoride analysis uses an isocratic elution of NaF in a Hamilton anion-exchange column using a mobile phase that consists of 7.5 mM sodium carbonate and 0.018 mM potassium thiocyanate. The flow rate was 1.0 ml/min. The method was validated in accordance with several parameters, including syst... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772948 Thu, 30 Dec 2010 00:00:00 +0100 4772948 http://www.medworm.com/index.php?rid=4772945&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004798%2Fabstract%3Frss%3Dyes Conclusion: Despite promising results on the labeling and in vitro stability of 201Tl(III)–DOTA, our in vivo results indicate that the integrity of 201Tl(III)–DOTA decreases to (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772945 Thu, 30 Dec 2010 00:00:00 +0100 4772945 http://www.medworm.com/index.php?rid=4772943&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004816%2Fabstract%3Frss%3Dyes Conclusion: This study addresses the feasibility of imaging of myocardial cell death in acute ischemia and RI in pigs with 99mTc-His10-annexin V; it holds prospect for the detection of myocardial cell death in clinical practice. Adenosine preconditioning could attenuate the myocardial apoptosis; its cardioprotective effect might partially be fulfilled by suppressing the ongoing apoptosis in ischemia and reperfusion. Further study is warranted. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772943 Thu, 30 Dec 2010 00:00:00 +0100 4772943 http://www.medworm.com/index.php?rid=4467782&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004129%2Fabstract%3Frss%3Dyes Abstract: The aim of this work was to study the feasibility of using Positron Emission Tomography (PET) imaging as a new tool to detect transdermal penetration of topical drugs in human subjects. The compound used in the study is sodium 2-[(2,6-dichlorophenyl)amino]phenyl]acetate, better known as diclofenac sodium. This molecule belongs to the family of non-steroidal anti-inflammatory drugs and is considered one of the first choices among non-steroidal anti-inflammatory drugs for the treatment of inflammatory diseases; it is widely used and commercially present in a large number of pharmaceutical forms and formulations. 11C-labeled diclofenac has been synthesized and coformulated, as an internal indicator, with a proprietary preparation based on the use of a sprayer. The radiolabeled prepa... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4467782 Thu, 09 Dec 2010 00:00:00 +0100 4467782 http://www.medworm.com/index.php?rid=4772941&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004749%2Fabstract%3Frss%3Dyes Conclusions: Improvements in stability were not sufficient to outweigh the low somatostatin receptor affinity for the peptides in this study. Further improvements in the peptide sequence and/or metal coordination are needed to result in a radiodiagnostic/radiotherapeutic pair for targeting the somatostatin receptor. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4772941 Fri, 03 Dec 2010 00:00:00 +0100 4772941 http://www.medworm.com/index.php?rid=4706636&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004476%2Fabstract%3Frss%3Dyes Conclusion: Effective dose estimates for [11C]CHIBA-1001 were compatible with those associated with other common nuclear medicine tests. Absorption doses among several organs were considerably different between the human and mouse studies. Human dosimetry studies for the investigation of radiation safety are desirable as one of the first clinical trials of new PET probes before their application in subsequent clinical investigations. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4706636 Fri, 03 Dec 2010 00:00:00 +0100 4706636 http://www.medworm.com/index.php?rid=4706635&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004440%2Fabstract%3Frss%3Dyes In this study, we investigate the efficiency of synthesis of terminally [18F]fluorinated fatty acid analogs using a commercial microwave reactor in comparison with conventional heating (CH).Methods: The labeling precursors were methyl esters of terminally substituted alkyl bromides and iodides. Duration and temperatures of the [18F]fluorination reaction were varied. Chemical and radiochemical purities, and radiochemical yields were investigated for conventional (CH) and microwave-assisted (MW) radiosyntheses.Results: The results demonstrate that microwave heating enhanced [18F]fluoride incorporation to >95% (up to 55% improvement), while reducing reaction times to 2 min (∼10-fold reduction) or temperatures to 55–60°C (20°C reduction). Overall decay-corrected radiochemical yields of p... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4706635 Fri, 03 Dec 2010 00:00:00 +0100 4706635 http://www.medworm.com/index.php?rid=4706634&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004506%2Fabstract%3Frss%3Dyes Abstract: Introduction: Recently, first applications of microfluidic principles for radiosyntheses of positron emission tomography compounds were presented, but direct comparisons with conventional methods were still missing. Therefore, our aims were (1) the set-up of a microfluidic procedure for the preparation of the recently developed adenosine A3-receptor tracers [18F]FE@SUPPY [5-(2-[18F]fluoroethyl)2,4-diethyl-3-(ethylsulfanylcarbonyl)-6-phenylpyridine-5-carboxylate] and [18F]FE@SUPPY:2 [5-ethyl-2,4-diethyl-3-((2-[18F]fluoroethyl)sulfanylcarbonyl)-6-phenylpyridine-5-carboxylate] and (2) the direct comparison of reaction conditions and radiochemical yields of the no-carrier-added nucleophilic substitution with [18F]fluoride between microfluidic and conventional methods.Methods: For the... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4706634 Fri, 03 Dec 2010 00:00:00 +0100 4706634 http://www.medworm.com/index.php?rid=4706633&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004555%2Fabstract%3Frss%3Dyes Conclusion: The study demonstrated that MDP could be labeled with 177Lu with high radiochemical yields (>99%). The in vitro stability of the complex was found adequate. Biodistribution studies in Sprague-Dawley rats indicated selective bone accumulation, relatively low uptake in soft tissue (except liver) and higher skeletal uptake, suggesting that it may be useful as a bone pain palliation agent for the treatment of bone metastases. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4706633 Fri, 03 Dec 2010 00:00:00 +0100 4706633 http://www.medworm.com/index.php?rid=4706632&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS0969805110004464%2Fabstract%3Frss%3Dyes We report on an efficient procedure for the preparation of [188Re(N)(PNP)]-based complexes (where PNP is diphosphinoamine) useful in the development of target-specific radiopharmaceuticals. The radiochemical yield of the compounds was optimized considering such reaction parameters as nature of the nitrido nitrogen donor, reaction times and pH level. The chemical identity of the 188Re agents was determined by high-performance liquid chromatography comparison with the corresponding well-characterized cold Re compounds. 188Re(N) mixed compounds have been evaluated with regard to stability toward transchelation with GSH and degradation by serum enzymes. The clearance of selected radiocompounds from normal tissues and their in vivo stability were evaluated in rats by biodistribution and imaging... Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4706632 Fri, 03 Dec 2010 00:00:00 +0100 4706632 http://www.medworm.com/index.php?rid=4706631&cid=s_38706_37_f&fid=38706&url=http%3A%2F%2Fwww.nucmedbio.com%2Farticle%2FPIIS096980511000452X%2Fabstract%3Frss%3Dyes Conclusion: The preliminary results suggest that 68Ga-TF is capable of detecting S. aureus infection in the rat model, within an hour after intravenous injection. (Source: Nuclear Medicine and Biology) Nuclear Medicine and Biology journals http://www.medworm.com/rss/comments.php?id=4706631 Fri, 03 Dec 2010 00:00:00 +0100 4706631