MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Oral Oncology' source. Tue, 16 Mar 2010 13:54:24 +0100 http://www.medworm.com/index.php?rid=3295627&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837510000382%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295627 Tue, 23 Feb 2010 13:49:48 +0100 3295627 http://www.medworm.com/index.php?rid=3295633&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009798%2Fabstract%3Frss%3Dyes Summary: Head-and-neck (H&N) tumor re-growth is clinically observed after arrest of anti-EGFR therapies. In the present study, we compared, for a similar dose exposure to anti-EGFR therapies, constant (CS) with tapered (TS) schedules (i.e. progressive dose reduction) for cetuximab, a mAb, and gefitinib, a TKI.Mice bearing CAL33 H&N tumors with high EGFR content were treated with cetuximab or gefitinib. CS consisted of 7days of cetuximab or gefitinib administration and TS of 7days of drugs followed by 7days of administration at decreased doses (divided by 2 every day).Gefitinib TS but not CS slowed down tumor re-growth. Cetuximab TS had a stronger and longer-lasting effect than CS, paralleled by a down-regulation of EGFR expression.Whatever the drug, TS decreased tumor re-growth more effici... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295633 Tue, 16 Feb 2010 00:00:00 +0100 3295633 http://www.medworm.com/index.php?rid=3295640&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509010124%2Fabstract%3Frss%3Dyes Summary: We evaluated the prognostic significance of excision repair cross-complementation group 1 protein (ERCC1) and thymidylate synthase (TS) in patients with nasopharyngeal cancer (NPC) treated with concurrent chemoradiotherapy (CCRT). Pre-treatment tumor biopsy specimens from 41 patients with locally advanced NPC (stage I: 1, II: 10, III: 9, IV: 21 patients) were analyzed for ERCC1 and TS expression by immunohistochemistry. All patients were treated with one cycle of induction chemotherapy (5-fluorouracil 1000mg/m2/day and cisplatin 20mg/m2/day, days 1–4) followed by CCRT starting on day 22. CCRT consisted of radiotherapy (70Gy/35 fractions for 7weeks) with cisplatin 20mg/m2/day for 4days on weeks 1, 4, and 7 of radiotherapy. High expression of ERCC1 and TS was observed in 25 (60%) ... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295640 Fri, 12 Feb 2010 00:00:00 +0100 3295640 http://www.medworm.com/index.php?rid=3295641&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837510000023%2Fabstract%3Frss%3Dyes Summary: Bisphosphonates (BP) have been associated with the occurrence of osteonecrosis of the jaw (ONJ), possibly by causing an excessive bone turnover inhibition. However, little in vivo evidence exists to support this theory.The 99mTc-medronate scintigrams of patients with skeletal metastases and BP use (n=40) were individually matched with cancer patients without BP exposure (n=40) and controls with neither malignancy nor BP use (n=40). Patients with established ONJ or intense focal abnormalities in the studied regions were excluded. Mandibular (MBT) bone turnover was quantified relative to the femur by defining regions-of-interest with correction for background activity.The patients with BP exposure (34 female, 6 male) had a median age of 63years (range 25–81) and received a median ... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295641 Mon, 08 Feb 2010 00:00:00 +0100 3295641 http://www.medworm.com/index.php?rid=3295639&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509010100%2Fabstract%3Frss%3Dyes This study showed that miR-24 was up-regulated in OSCC tissues relative to control samples. In addition, the plasma levels of miR-24 in OSCC patients were significantly higher than in control individuals. miR-24 expression was also higher in OSCC cell lines relative to normal oral keratinocytes. Experiments blocking miR-24 and using exogenous miR-24 expression indicated that miR-24 contributes to the growth of OSCC cells and that miR-24 may target p57. This study suggests that miR-24 is involved in the regulation of OSCC growth and that the miR-24’s level in plasma may be validatable as a tumor marker for OSCC patients. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295639 Mon, 08 Feb 2010 00:00:00 +0100 3295639 http://www.medworm.com/index.php?rid=3295638&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509010094%2Fabstract%3Frss%3Dyes The objective of this study was to determine if lower SES is associated with a similar increase in the incidence of HNC in Canadian patients.We obtained data on SES (income, education and immigration status), demographic characteristics, frequency of dental visits and smoking behavior for adult patients residing in the Eastern Ontario region who were referred to the Ottawa Regional Cancer Centre with HNC. We compared the SES and frequency of dental visits of these HNC patients with the SES and frequency of dental visits of a control sample in the same region from the 2004–2005 Statistics Canada Canadian Community Health Survey (CCHS 3.1). We then performed a logistic regression analysis on the combined sample of patients and controls using incidence of HNC as the dependent variable. This... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295638 Mon, 08 Feb 2010 00:00:00 +0100 3295638 http://www.medworm.com/index.php?rid=3295629&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509010148%2Fabstract%3Frss%3Dyes Summary: Plasmablastic lymphoma (PBL) is a rare AIDS associated non-Hodgkin’s lymphoma (NHL), with predilection for the mucosa of oral cavity. It usually has a plasmablastic morphology, expressing plasma cell-associated antigens with weak or no expression of B-cell associated markers. The tumor cells also show monoclonal rearrangement of the immunoglobulin heavy chain gene (IgH) and/or clonal restriction of Ig light chain (IgL) gene expression in most of the cases. An etiological role for EBV seems likely but the association with HHV8 is questionable. The treatment guidelines for PBL are not well defined and patients have been treated heterogeneously with chemo and/or radiotherapy, although the prognosis is poor. The present article discusses the 68 cases reported in English medical lite... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295629 Mon, 08 Feb 2010 00:00:00 +0100 3295629 http://www.medworm.com/index.php?rid=3295628&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509010112%2Fabstract%3Frss%3Dyes Summary: Important advances in Kaposi’s sarcoma (KS) knowledge have been achieved, but KS is still a dilemma. It is an angioproliferative disorder classified as an intermediate neoplasm due to the absence of conventional clinical features of malignancy, but at the moment, it remains unclear if KS could be considered a reactive proliferation of endothelial cells and spindle cells, a true malignancy or both. In this review, the authors address the main epidemiological, clinical, and biological features, of the five types of KS, with emphasis on KS affecting the head and neck region. Also, a revision is done in relation with transmission, the role of saliva, and the pathogenic events associated with human herpesvirus type-8 (HHV-8). Treatment options are revised, highlighting the need for f... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295628 Mon, 08 Feb 2010 00:00:00 +0100 3295628 http://www.medworm.com/index.php?rid=3213756&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883751000014X%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3213756 Thu, 28 Jan 2010 13:54:19 +0100 3213756 http://www.medworm.com/index.php?rid=3295637&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009993%2Fabstract%3Frss%3Dyes Abstract: Mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) are salivary gland neoplasms with divergent morphological features and clinical behavior. ACC is a basaloid tumor whereas MEC is a glandular epithelial neoplasm. FHIT and WWOX are tumor suppressor genes that encompass the FRA3B and FRA16D fragile sites at chromosomes 3p14.2 and 16q23.3, respectively. In previous studies, we have shown concordant loss of Fhit and Wwox expression in breast cancer, with significantly more frequent loss in cancers of basal-like phenotype. To determine if there is a similar association in salivary gland neoplasms, we designed a study of MEC and ACC of salivary gland on tissue microarrays (TMA). TMAs were constructed from 25 MEC and 19 ACC of salivary gland. Fhit and Wwox protein express... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295637 Mon, 11 Jan 2010 00:00:00 +0100 3295637 http://www.medworm.com/index.php?rid=3295636&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009877%2Fabstract%3Frss%3Dyes Summary: The French national health insurance reimbursement system has recently changed from a global hospital funding system to casemix-based funding. The authors studied the factors likely to influence the length of hospital stay for free flap reconstructions after surgery for cancers of the oral cavity or pharynx.Data concerning 207 oral cavity or pharynx free flap reconstructions were extracted from a prospective registration. Lengths of hospital stay were compared by an analysis of variance F test or a nonparametric Kruskal–Wallis test, and transfusion rates were compared by Chi-square test or Fisher’s exact test, as appropriate.The median length of hospital stay was 24days (range: 7–145days). Length of hospital stay was significantly longer according to the type of flap (p (Sou... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295636 Mon, 11 Jan 2010 00:00:00 +0100 3295636 http://www.medworm.com/index.php?rid=3295635&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009853%2Fabstract%3Frss%3Dyes Summary: Granzyme B (GB) is a serine protease synthesized by activated cytotoxic T-lymphocytes and natural killer cells that induces neoplastic cells apoptosis. The expression of GB in the tumor microenvironment has been considered a favorable prognostic factor in several types of human cancers. Thus, the aim of this study was to evaluate the density of GB+ cells in samples of oral cavity squamous cell carcinoma (OCSCC), as well as their relationship with clinical and microscopic parameters. GB expression was analyzed in 55 cases of OCSCC and metastatic and non-metastatic lymph nodes by means of immunohistochemistry. The high density of GB+ cells demonstrated an association with the high percentage of Bax+ and annexin V+ neoplastic cells. In addition, the number of peritumoral GB+ cells wa... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295635 Mon, 11 Jan 2010 00:00:00 +0100 3295635 http://www.medworm.com/index.php?rid=3295632&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009786%2Fabstract%3Frss%3Dyes Summary: Squamous cell carcinoma of the oral cavity (OSCC) is a malignancy characterized by a high degree of local aggression and metastasis to cervical lymph nodes. Tetraspanins are proteins with functional roles in a wide array of cellular processes and are reported to be associated with tumor progression. The present study investigated the expression of the CD9, CD37, CD63, CD81 and CD82 tetraspanins in OSCC using immunohistochemistry (IHC) and quantitative Real Time-PCR (qRT-PCR). Tissue microarray (TMA) analysis of samples from 179 cases of OSCC and 10 normal samples oral mucosa were evaluated immunomorphologically. We analyzed CD9 and CD82 expression by qRT-PCR in 66 OSCC cases and 4 normal samples of oral mucosa. Expression of CD63, CD37 and CD81 was not detected in the samples stud... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295632 Mon, 11 Jan 2010 00:00:00 +0100 3295632 http://www.medworm.com/index.php?rid=3213760&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009841%2Fabstract%3Frss%3Dyes Summary: Estimating the value of our preoperative workup in the treatment of patients with clinically N0 (cN0) squamous cell carcinoma of the oral cavity. Retrospective analysis. Results of preoperative palpation, ultrasound (US) and ultrasound-guided fine needle aspiration cytology (FNAC) were compared to the histological findings after unilateral or bilateral elective selective neck dissection of level I–III (SND I–III) in patients with cN0 squamous cell carcinoma of the oral cavity. Occult metastases were detected by in 50 (22%) out of the 224 cN0 patients. No metastases were found beyond level III in extended neck dissections. T1N0M0 tumors and T2N0M0 tumors metastasized in 8 out of 77 cases (10%) and 32 out of 112 (29%) cases, respectively. Staging of the cN0 neck by palpation and... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3213760 Mon, 11 Jan 2010 00:00:00 +0100 3213760 http://www.medworm.com/index.php?rid=3213768&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883750900983X%2Fabstract%3Frss%3Dyes Summary: Glutathione S-transferases (GST) are antioxidant enzymes and oxidative stress markers in oral carcinogenesis. They present a system of polymorphic proteins. Some variants are associated with increased sensitivity to toxic compounds, as it is known for the GSTM1-null variant allele. However, the influence of the GSTM1 allele variant genotype on GSTM1-mRNA quantity in oral squamous cell carcinoma (OSCC) and normal mucosa as well as the impact on prognosis remains unclear. The genotype for GSTM1 (mutation vs. wild type) was determined by polymerase chain reaction (PCR) using genomic DNA extracted from peripheral blood from 28 OSCC patients. From the same patients, 28 pairs of OSCC cells and normal oral mucosal cells were obtained by brush biopsy. mRNA was extracted from these paired ... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3213768 Fri, 08 Jan 2010 00:00:00 +0100 3213768 http://www.medworm.com/index.php?rid=3295630&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009749%2Fabstract%3Frss%3Dyes Summary: We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p=0.013), lymph node metastasis (p=0.001), tumor stage (p=0.031) and tumor recurrence (p=0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r=0.223, p=0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295630 Thu, 07 Jan 2010 00:00:00 +0100 3295630 http://www.medworm.com/index.php?rid=3295634&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009828%2Fabstract%3Frss%3Dyes The objective of this study was to evaluate the effect of Dox on the expression of MMPs in vitro using the SCC-15 cell line and in vivo SCC-15 xenografted nude mice. SCC-15 cells maintained under distinct culture conditions expressed high levels of pro-MMP-2 and pro-MMP-9; however, as determined by zymography and Western blot analysis, Dox significantly reduced the production of pro-MMP-2 and pro-MMP-9 after 24h of treatment in a dose-dependent manner (2.5–40μg/ml). Dox (10μg/ml) decreased the expression of MMP-9 mRNA but did not alter the level of MMP-2 mRNA after 24h of treatment. In addition, this drug significantly inhibited the invasive and migration activities of SCC-15 cells in vitro (>75% inhibition at 10μg/ml). On the other hand, daily administration of Dox (3mg/mice) restrai... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295634 Mon, 28 Dec 2009 00:00:00 +0100 3295634 http://www.medworm.com/index.php?rid=3295631&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009762%2Fabstract%3Frss%3Dyes In this study, we demonstrated that HNSCC-ALDH1+ cells possess tumor initiating properties, are capable of self-renewal, and express higher levels of Bmi-1 as compared to HNSCC-ALDH1− cells. To further explore the functional role of Bmi-1 in HNSCC-ALDH1+ cells, we used a lentiviral vector expressing shRNA to knock down Bmi-1 expression (sh-Bmi-1) in HNSCC-ALDH1+ cells. Silencing of Bmi-1 significantly enhanced the sensitivity of HNSCC-ALDH1+ cells to chemoradiation and increased the degree of chemoradiation-mediated apoptosis that occurred. Importantly, knockdown of Bmi-1 increased the effectiveness of radiotherapy and led to the inhibition of tumor growth in nude mice transplanted with HNSCC-ALDH1+ cells. Kaplan–Meier survival analysis indicated that the mean survival rate of HNSCC-AL... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3295631 Mon, 28 Dec 2009 00:00:00 +0100 3295631 http://www.medworm.com/index.php?rid=3213767&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009816%2Fabstract%3Frss%3Dyes Summary: Oral leukoplakia is defined as a white patch in the oral cavity that cannot be diagnosed as any other known disorder. These lesions carry an increased risk of malignant progression, and approximately 2–3% per year do progress to cancer. At present biopsies are histopathologically graded for dysplasia to assess the risk of progression, but this grading is somewhat subjective and of limited use for the individual patient.In a previous study we discovered by a comprehensive proteomics approach that compared to normal mucosa, protein expression of cornulin, keratin 4 and keratin 13 is decreased in tumors and severe dysplasia, preneoplastic tissue with a high risk of malignant progression. Here, we studied whether loss of expression of these proteins can predict malignant transformat... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3213767 Mon, 28 Dec 2009 00:00:00 +0100 3213767 http://www.medworm.com/index.php?rid=3213766&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009804%2Fabstract%3Frss%3Dyes Summary: Head and neck squamous cell carcinomas (HNSCCs) are the most frequent malignancies of the upper aerodigestive tract. The cancer stem cell (CSC) hypothesis concludes that CSCs constitute the dangerous tumor cell population due to their ability of self-renewal and being associated with relapse of tumor disease, invasiveness and resistance to chemo(radio)therapy. The aim of this study was to look for CSC candidates and expression of MMP-9 that previously was implicated in HNSCC invasiveness.Immunohistochemical, immunofluorescence and Western blot analysis were performed on HNSCC tumor specimens using antibodies specific for MMP-9, CD44, ALDH1 and CK14. Gelatinolytic activity was assessed by zymography. Pearson correlation analysis was used for statistical comparison.Immunohistochemic... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3213766 Mon, 28 Dec 2009 00:00:00 +0100 3213766 http://www.medworm.com/index.php?rid=3213765&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009865%2Fabstract%3Frss%3Dyes In this study, tumor growth and intratumoral expression level of VEGF-C and -D following administration of local hyperthermia was evaluated in nude mice model of tongue squamous cell carcinoma (SCC). The data demonstrated that the size of tumor in local hyperthermia was 26.5% of control group, and that local hyperthermia markedly suppressed the mRNA and protein expression of VEGF-C and -D as determined by quantitative real-time RT-PCR, Western blot and immunohistochemistry (P (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3213765 Mon, 28 Dec 2009 00:00:00 +0100 3213765 http://www.medworm.com/index.php?rid=3213763&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009737%2Fabstract%3Frss%3Dyes Summary: Patients with HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are significantly different with regard to sociodemographic and behavioral characteristics that clinicians may use to assume tumor HPV status.Machine learning methods were used to evaluate the predictive value of patient characteristics and laboratory biomarkers of HPV exposure for a diagnosis of HPV16-positive HNSCC compared to in situ hybridization, the current gold-standard.Models that used a combination of demographic characteristics such as age, tobacco use, gender, and race had only moderate predictive value for tumor HPV status among all patients with HNSCC (positive predictive value [PPV]=75%, negative predictive value [NPV]=68%) or when limited to oropharynx cancer patients (PPV=55%,... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3213763 Mon, 28 Dec 2009 00:00:00 +0100 3213763 http://www.medworm.com/index.php?rid=3213761&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009348%2Fabstract%3Frss%3Dyes Summary: There are few data focusing on postoperative course after major head and neck cancer surgery in the elderly compared with the younger population. The aim of this study was to assess the impact of age on postoperative outcomes.At hospital admission, we prospectively collected data from 261 patients separated into two groups with regard to their age (those ⩾70years and those (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3213761 Mon, 28 Dec 2009 00:00:00 +0100 3213761 http://www.medworm.com/index.php?rid=3213759&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008501%2Fabstract%3Frss%3Dyes Summary: In Latin America, maté is consumed as a beverage regularly. Among the cancers that are associated with maté drinking is oral and oro-pharyngeal cancer, incidence of which is high in the region. In order to further understand this association between maté drinking and the risk of oral and oro-pharyngeal cancer, we performed a systematic review and meta-analysis of related studies. All relevant studies published in English as original articles up to June 2009 were identified through a literature search using PubMed and Medline and by reviewing the references from the retrieved articles. Four case–control studies done in Latin America were identified. There were 879 maté users and 1128 non- or low-maté users in those studies with a total of 566 oral and oro-pharyngeal cancers.... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3213759 Mon, 28 Dec 2009 00:00:00 +0100 3213759 http://www.medworm.com/index.php?rid=3213758&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009774%2Fabstract%3Frss%3Dyes Summary: Taste dysfunction in cancer patients impacts quality of life and impairs oral intake, which may have broader implications consisting of weight loss and nutritional compromise. These consequences may in turn affect broad symptom clusters including tissue healing, energy levels and mood. Patient evaluation and management should include a complete patient history and examination, and may require special tests. Patient-reported outcomes together with taste and smell testing are often necessary for diagnosis and management of taste disorders. Understanding, prevention and management of taste disorders in cancer patients requires continuing study. Current practice and recommendations are based on limited evidence. Due to its potentially significant impact on quality of life during and f... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3213758 Mon, 28 Dec 2009 00:00:00 +0100 3213758 http://www.medworm.com/index.php?rid=3213757&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009750%2Fabstract%3Frss%3Dyes Summary: Reconstruction of the mandible has evolved significantly over the last 40years. Early attempts were often disfiguring and wrought with complications but with the introduction of free tissue transfer of well vascularized bone in the 1970’s there was a significant improvement in outcomes. In recent years the harvest, inset, and microvascular anatomosis have been refined to the point that success rates are reported as high as 99% throughout the literature. Focus has now shifted to optimizing functional and aesthetic outcomes after mandible reconstruction. This paper will be a review defect classification, goals of reconstruction, the various donor sites, dental rehabilitation, new advances, and persistent problems.Reconstruction of segmental mandibular defects after ablative surger... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3213757 Mon, 28 Dec 2009 00:00:00 +0100 3213757 http://www.medworm.com/index.php?rid=3116430&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009944%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116430 Thu, 24 Dec 2009 13:47:41 +0100 3116430 http://www.medworm.com/index.php?rid=3116414&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009907%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116414 Thu, 24 Dec 2009 13:47:38 +0100 3116414 http://www.medworm.com/index.php?rid=3213764&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008227%2Fabstract%3Frss%3Dyes This study was designed to investigate the chemopreventive effects of ZSP on oral cancer in animal models and human patients. In the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch model, ZSP (6g/kgBW/day by gavage for 10 weeks) significantly reduced the number of visible tumor, the tumor volume, and the incidence of SCC (P (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3213764 Mon, 21 Dec 2009 00:00:00 +0100 3213764 http://www.medworm.com/index.php?rid=3116429&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009671%2Fabstract%3Frss%3Dyes Summary: The aim of this study was to examine the Kif2a expression and its role in tumor progression, invasion and metastasis in squamous cell carcinoma of the oral tongue (SCCOT). The study included 44 cases of primary tumor and the corresponding adjacent tissues, 20 cases of primary tumor with lymph node metastasis. Immunohistochemistry was used to observe the Kif2a expression and its correlation with clinicopathologic factors in oral tongue cancer. The immunohistochemistry showed that Kif2a expression was stronger in oral tongue cancer tissues than in paired adjacent tissues (P (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116429 Mon, 14 Dec 2009 00:00:00 +0100 3116429 http://www.medworm.com/index.php?rid=3116426&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009476%2Fabstract%3Frss%3Dyes Summary: Locoregional recurrence in patients with early stage oral cavity squamous cell carcinoma (ESOSCC) after surgery remains a problem and can affect their survival. We sought to identify new high-risk factors in these patients, who need further adjuvant therapy.We retrospectively reviewed records for 148 patients who underwent surgery for ESOSCC between 2002 and 2006 with negative surgical margins. The primary endpoint was locoregional recurrence. Recurrence-free survival (RFS) and overall survival (OS) were calculated by the Kaplan–Meier method. Univariate and multivariate analyses were used to identify independent predictors of locoregional recurrence. All patients were grouped into the low- and high-risk groups according to the odds ratios (OR) of the predictors. Recurrence rates... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116426 Mon, 14 Dec 2009 00:00:00 +0100 3116426 http://www.medworm.com/index.php?rid=3116417&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009440%2Fabstract%3Frss%3Dyes The coming of age is the point (most commonly 18 y) at which time adolescents are generally granted the full rights of an adult. Oral Oncology was launched in 1992, and has thus reached its coming of age with all the pointers to indicate it will thrive well into the future. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116417 Mon, 14 Dec 2009 00:00:00 +0100 3116417 http://www.medworm.com/index.php?rid=3213762&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009464%2Fabstract%3Frss%3Dyes Summary: Cigarette smoke creates a field of injury in the epithelial lining of the entire respiratory tract causing an increased risk for the development of malignant lesions. It is conceivable, therefore, that early genetic alterations, can be detected in oral mucosa of heavy smokers mainly those affected by lung cancer. As aneuploidy was shown to be an early event in oral carcinogenesis, we aimed to investigate the prevalence of aneuploid cells (ACs) in samples obtained from apparently normal looking oral mucosa of heavy smokers affected by lung cancer (LC). Two brush samples were collected from the oral mucosa of 152 subjects; 31 heavy smokers with LC, 59 heavy smokers without LC and 62 never-smokers. The samples were simultaneously analyzed for morphology and fluorescent in situ hybrid... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3213762 Thu, 10 Dec 2009 00:00:00 +0100 3213762 http://www.medworm.com/index.php?rid=3116428&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883750900966X%2Fabstract%3Frss%3Dyes Summary: The 40-years of experience in a single institution with the treatment of previously untreated ameloblastoma have been reported, followed by a management protocol. Retrospectively, 25 consecutive patients treated between 1969 and 2009 have been analyzed. In 11 patients, a preoperative diagnosis of ameloblastoma was available. In the remaining 14 patients the diagnosis of ameloblastoma was a postoperative one. For the recurrence rate a minimum follow-up period of 5 years was observed; 20 patients met these criteria.After primary radical surgery in five patients, no recurrences were observed. In case of conservative surgical treatment, performed in 15 patients, a recurrence was observed in eight (53%) of them. Six of these patients were then treated successfully by radical surgery, w... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116428 Thu, 10 Dec 2009 00:00:00 +0100 3116428 http://www.medworm.com/index.php?rid=3116427&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009488%2Fabstract%3Frss%3Dyes Summary: To investigate employment in working-age head and neck cancer (HNC) survivors before and after treatment in relation to sociodemographic and clinical factors, health related quality of life, and emotional distress.Patients younger than 65years at time of diagnosis and at least 2years after curative treatment for HNC were included. Exclusion criteria were cognitive dysfunction and no understanding of Dutch language. Primary outcome measures were employment status and return to work assessed by a study specific questionnaire. Secondary outcome measures were health related quality of life (EORTC QLQ-C30 and QLQ-H&N35) and emotional distress (Hospital Anxiety and Depression Scale (HADS)). Sociodemographic and disease and treatment related parameters, health related quality of life, an... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116427 Thu, 10 Dec 2009 00:00:00 +0100 3116427 http://www.medworm.com/index.php?rid=3116421&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009452%2Fabstract%3Frss%3Dyes Summary: In the classification of Head and Neck Tumors, published in 2005 by the World Health Organization Classification, the odontogenic keratocyst has been reclassified as a benign intraosseous neoplasm, calling it “keratocystic odontogenic tumor” (KCOT).Significant differences on the molecular level between KCOT and other odontogenic cystic lesions suggest a different biological origin. Genetic and molecular research regarding odontogenic tumors, and KCOTs in particular, has led to an increasing amount of knowledge and understanding of their physiopathological pathways.A review of the biological behavior of this recognized aggressive pathological entity of the jaws and a contemporary outline of the molecular (growth factors, p53, PCNA and Ki-67, bcl-2) and genetic (PTCH, SHH) alter... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116421 Thu, 10 Dec 2009 00:00:00 +0100 3116421 http://www.medworm.com/index.php?rid=3116425&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009439%2Fabstract%3Frss%3Dyes Summary: Oral squamous cell carcinoma (OSCC) develops slowly and it is usually preceded by identifiable oral preneoplastic lesions (OPLs): chemoprevention could be a promising approach. Resveratrol (RV) is a plant-based agent characterized by a strong in vitro antineoplastic action, but this effect has not been clinically confirmed owing to its metabolic inactivation. In order to circumvent this limitation and to improve RV efficacy, it was locally applied and complexed with a protective and solubilising vehicle (2-hydroxypropyl-β-cyclodextrin, HPβCD). The experimentation was performed in vitro on 7,12-dimethylbenz[a]anthracene-induced hamster OSCC cell line (HCPC I) and in vivo in the related animal model, by comparison of two RV–HPβCD formulations (cream and mouthwash) and RV alone.... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116425 Mon, 23 Nov 2009 00:00:00 +0100 3116425 http://www.medworm.com/index.php?rid=3116424&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009397%2Fabstract%3Frss%3Dyes Summary: The need for elective neck dissection in patients with early stage oral cancer is controversial. A preoperative predictor of the risk of subclinical nodal metastasis would be useful. Studies have shown a strong correlation between histological tumor depth and the risk of nodal metastasis.To determine if preoperative ultrasonography is an accurate measure of tumor depth in oral carcinoma. To assess if preoperatively measured tumor depth predicts an increased risk of subclinical metastatic neck disease and thus the need for elective neck dissection.Twenty one consecutive patients with biopsy proven squamous cell carcinoma of the tongue/floor of mouth were analyzed prospectively. Each patient received a preoperative ultrasonography to assess tumor depth which was compared to histolog... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116424 Mon, 23 Nov 2009 00:00:00 +0100 3116424 http://www.medworm.com/index.php?rid=3116423&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009385%2Fabstract%3Frss%3Dyes This study indicated a high fidelity of GFP reporter gene expression in the tongue under the control of zebrafish keratin 5 promoter. This zebrafish transgenic model system may be used for future studies on oral development and cancer. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116423 Mon, 23 Nov 2009 00:00:00 +0100 3116423 http://www.medworm.com/index.php?rid=3116420&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009373%2Fabstract%3Frss%3Dyes Summary: The diagnosis of a paraneoplastic syndrome (PNS) may precede, follow or be concurrent with the diagnosis of a malignant tumor. There is increasing knowledge of association between PNS and head and neck cancers, but the relationship between oral cancer and paraneoplastic disease has not been previously investigated. PNS associated with head and neck cancer can be divided into six main groups: endocrine, cutaneous or dermatologic, hematologic, osteoarticular or rheumatologic, neurologic, and ocular syndromes. We have comprehensively reviewed the literature to evaluate the incidence of occurrence of PNS with oral cancer, and conclude that only endocrine and dermatologic PNS have been associated with oral cancer. Humoral hypercalcemia is the most frequent PNS related to oral cancer, a... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116420 Mon, 23 Nov 2009 00:00:00 +0100 3116420 http://www.medworm.com/index.php?rid=3116416&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009427%2Fabstract%3Frss%3Dyes This study confirmed the results of a previous study performed by the same research team, where kappa for lesion diagnosis was 0.59 (95% CI:0.45, 0.72) for the entire study population. With recategorization of the lesions into three groups as “no abnormality/hyperkeratosis”, “mild, moderate or severe dysplasia” and “carcinoma-in situ and carcinoma”, the agreement between the pathologists increased to 0.70 (95% CI:0.56, 0.84). Lesions without inflammation had higher kappa values when compared to that of the lesions with inflammation (kappa values 0.67 (95% CI:0.53, 0.80) and −0.10 (95% CI:0.27, 0.07), respectively). Thus, the reliability of histopathology to estimate the risk of progression of a potentially malignant lesion continues to be of concern, because variability in in... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116416 Mon, 23 Nov 2009 00:00:00 +0100 3116416 http://www.medworm.com/index.php?rid=3116415&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009361%2Fabstract%3Frss%3Dyes Osteonecrosis of the jaws (ONJ) is a well-known, devastating side effect of long-term bisphosphonate use. Since it was first described in 2003, over 1000 cases have been reported in the literature, mostly in patients with multiple myeloma or bone metastases of solid tumors. These patients were usually being treated parenterally with high-potency bisphosphonates (e.g., zoledronic acid), but the number patients who acquire ONJ associated with oral bisphosphonates for osteoporosis is rising. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116415 Mon, 23 Nov 2009 00:00:00 +0100 3116415 http://www.medworm.com/index.php?rid=3009665&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009543%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009665 Fri, 20 Nov 2009 13:50:28 +0100 3009665 http://www.medworm.com/index.php?rid=3009641&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009518%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009641 Fri, 20 Nov 2009 13:50:22 +0100 3009641 http://www.medworm.com/index.php?rid=3116419&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009178%2Fabstract%3Frss%3Dyes Summary: Oral cancer is the sixth most common cancer worldwide and a major health problem in some parts of the world. Epidemiological studies have shown that habitual alcohol consumption could be a risk factor in oral carcinogenesis, although the true involvement of alcohol is unknown. Via alcohol dehydrogenase (ADH) and cytochrome P450 oxidase (CYP) alcohol is metabolized to acetaldehyde, a highly toxic compound, which plays an important role in carcinogenesis. Subsequently, and during the metabolizing process, acetaldehyde becomes acetate by acetaldehyde dehydrogenase (ALDH). Therefore, acetaldehyde levels are determined mainly by the action of ADH, CYP and ALDH. Recently, several studies have found that certain polymorphisms of genes encoding these enzymes confer a higher or lower metab... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116419 Fri, 06 Nov 2009 00:00:00 +0100 3116419 http://www.medworm.com/index.php?rid=3009651&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009324%2Fabstract%3Frss%3Dyes The impact factor (IF) has now been in use for some years, is well recognized by most readers, and may have some utility – but the disadvantages are also increasingly recognized. The five year Impact Factor, calculated in the same way as the regular IF, but measuring citations over a five year window rather than the two year window period of the regular IF, may reflect more accurately the impact of a journal. It has also been in use for some years. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009651 Fri, 06 Nov 2009 00:00:00 +0100 3009651 http://www.medworm.com/index.php?rid=3116418&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009166%2Fabstract%3Frss%3Dyes Abstract: A significant long-term side effect of radiation therapy for head and neck cancers is xerostomia, a dry mouth, due to salivary gland damage. Despite continuing efforts to eliminate this problem, many patients continue to suffer. This brief review describes our efforts to develop a gene transfer approach, employing the aquaporin-1 cDNA, to treat patients with existing radiation-induced salivary hypofunction. A Phase I/II clinical trial, using a recombinant adenoviral vector to mediate gene transfer, is currently underway. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116418 Thu, 05 Nov 2009 00:00:00 +0100 3116418 http://www.medworm.com/index.php?rid=3009664&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883750900935X%2Fabstract%3Frss%3Dyes Summary: Loss of the maxilla due to tumor ablation has both functional and aesthetic consequences. Even small defects become obvious because of missing bone and soft tissue. Reconstruction of the maxilla and midface in these patients presents a challenge to the surgeon although several possibilities are available for this purpose. The long term benefit to patients of the different modalities remains unclear due to wide individual variation.One hundred and twenty-one patients with maxillary oral squamous cell carcinoma were treated with curative intent. One hundred and five patients were surgically reconstructed using local or free microsurgical flaps. All parameters were collected from case records. Kaplan–Meier plots and univariate log-rank test and multivariate Cox proportional hazards... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009664 Wed, 04 Nov 2009 00:00:00 +0100 3009664 http://www.medworm.com/index.php?rid=3009649&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009312%2Fabstract%3Frss%3Dyes In response to an editorial from May 2008, ‘The real impact of oral oncology’, wherein you highlighted the improved rate of download of journals from your journal, we would like to draw your attention to some recent work carried by us on the theme of bibliometrics in oncology. Using the web service PubReMiner™ we identified the 10 journals which published most prolifically on oral cancer in 2007. We then determined their respective impact factors (IF), eigenfactors (EF), and citation rates using the 2007 edition of Thomson Scientific’s Journal Citation Report (JCR) (). The 10 most prolific journals produced a total of 495 articles relating to oral cancer in 2007. The median IF for these journals was just 1.4; they had a median eigenfactor of 0.011, and their median citation rate wa... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009649 Wed, 04 Nov 2009 00:00:00 +0100 3009649 http://www.medworm.com/index.php?rid=2905978&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009233%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905978 Tue, 20 Oct 2009 12:48:44 +0100 2905978 http://www.medworm.com/index.php?rid=2905958&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009208%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905958 Tue, 20 Oct 2009 12:48:38 +0100 2905958 http://www.medworm.com/index.php?rid=3116422&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009129%2Fabstract%3Frss%3Dyes Summary: Several studies have been suggesting annexin A1 protein as an active player in tumorigenesis of many organs. Nevertheless, its tumor biomarker role has been mainly studied in tissues by immunohistochemistry or cell culture. Hence, in this investigation, the peripheral blood from 27 oral squamous cell carcinoma (OSCC) patients and 25 negative control individuals were examined by quantitative real-time PCR. Down-regulated ANXA1 expression at mRNA level was observed in OSCC samples (p=0.026). Significantly diminished mRNA levels correlated to age, sex and the anatomical site of the tumor lesion were observed. Moreover, the ROC curve analysis revealed the performance of ANXA1 expression as a suitable biomarker for patients with oral cavity cancer, especially those with 60years of age ... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3116422 Thu, 15 Oct 2009 00:00:00 +0100 3116422 http://www.medworm.com/index.php?rid=3009655&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009087%2Fabstract%3Frss%3Dyes Summary: Oncolytic virotherapy utilizes viruses that can selectively destroy cancer cells without harming normal tissues. Clinical trials of oncolytic viruses show that most oncolytic agents are well tolerated and safe. The virotherapeutic agents currently in use have limited potency when administered alone; however, combination therapy using virotherapeutic agents and conventional anticancer agents, such as chemotherapeutics, radiation, and gene therapy, exhibits encouraging levels of efficacy. Advances in recombinant DNA technology have allowed the development of viruses that are tumor-selective and armed with transgenes, increasing the application potential and efficacy of this novel anticancer therapy. Here, we review the development of oncolytic viruses and the clinical trials of onco... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009655 Thu, 15 Oct 2009 00:00:00 +0100 3009655 http://www.medworm.com/index.php?rid=3009654&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008926%2Fabstract%3Frss%3Dyes Summary: The history of mucositis is as old as radiation- and chemotherapy. Despite being regularly reported and documented as one of the worst side effects of cancer therapy, relatively little was appreciated about the complexities of mucositis’ pathogenesis until relatively recently. More frustrating for patients and clinicians, no effective treatment existed. Fortunately, the situation is changing; ongoing research is leading to a comprehensive understanding of the biology of mucositis, which has resulted in the development of novel interventions. While the FDA’s approval of palifermin in 2004 was limited to only a small percentage of the at-risk population, the fact that the first registered anti-OM agent derived its efficacy from its pleotropic activities was conceptually demonstr... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009654 Thu, 15 Oct 2009 00:00:00 +0100 3009654 http://www.medworm.com/index.php?rid=3009652&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008495%2Fabstract%3Frss%3Dyes Summary: Saliva testing, a non-invasive alternative to serum testing, may be an effective modality for diagnosis and for prognosis prediction of oral cancer, as well as for monitoring post therapy status, by measuring specific salivary macromolecules, examining proteomic or genomic targets such as enzymes, cytokines, growth factors, metalloproteinases, endothelin, telomerase, cytokeratines, mRNA’s and DNA transcripts. Salivary analysis has been shown to be a useful diagnostic tool also for distant malignancies such as breast cancer. In recent years, significant alterations have been demonstrated in the saliva of oral cancer patients in the epithelial tumor markers – Cyfra 21-1, TPS and CA12, various oxidative stress-related salivary parameters as ROS and RNS, biochemical and immunologi... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009652 Thu, 15 Oct 2009 00:00:00 +0100 3009652 http://www.medworm.com/index.php?rid=3009650&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009075%2Fabstract%3Frss%3Dyes One of the brightest stars in the Head and Neck firmament was extinguished on 4 June 2009 with the untimely death of Professor Chris O’Brien at the age of 57. At the time of his enforced retirement when he was stricken with glioblastoma multiforme in November 2006, Chris was Australia’s leading academic head and neck surgeon with an international reputation for his contributions to the science and practice of head and neck oncology, including seminal papers on the biologic behaviour and management of skin cancers metastatic to the parotid gland and neck. He was Director of the Sydney Cancer Centre and the Sydney Head and Neck Cancer Institute and a champion of the cause of integrated multidisciplinary cancer care – a cause that he embraced, passionately and influentially, up to the ... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009650 Thu, 15 Oct 2009 00:00:00 +0100 3009650 http://www.medworm.com/index.php?rid=3009647&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509009063%2Fabstract%3Frss%3Dyes In this study, we used a retroviral infection method to over-express the human telomerase reverse transcriptase (hTERT) gene to acquire immortality of hTERT+-AM cells. Furthermore, it was revealed both by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot that the pathway of immortalization was loss of p16, not p53 or p21. Also, there was no evidence indicating that the hTERT+-AM cells underwent malignant transformation by the nude mouse tumorigenicity assay. Taken together, this hTERT-immortalized cell line may be a potentially valuable and reliable cell model for further study of the invasive properties of AM in vitro. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009647 Thu, 15 Oct 2009 00:00:00 +0100 3009647 http://www.medworm.com/index.php?rid=3009656&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509007817%2Fabstract%3Frss%3Dyes Summary: Reconstruction after extensive resection of the tongue remains a surgical challenge. Free soft-tissue transfer is now favored for head and neck reconstruction following cancer resection. However, the choice of either free tissue transfer (FTT) or of the pedicled Pectoralis Major Musculocutaneous Flap (PMMF), the workhorse in head and neck reconstruction, remains controversial. The purpose of this study is to assess the post-operative outcomes after radical ablative surgery and reconstruction for patients with a tongue cancer.We conducted a retrospective comparison of two different reconstruction techniques. From January 2000 to December 2006, 70 consecutive patients with tongue cancer had been treated with curative intent by extensive ablative surgery and soft-tissue reconstructio... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009656 Mon, 05 Oct 2009 00:00:00 +0100 3009656 http://www.medworm.com/index.php?rid=3009653&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008847%2Fabstract%3Frss%3Dyes Summary: The odontogenic keratocyst (keratocystic odontogenic tumour) (OKC) is one of the most prevalent odontogenic tumours. Since its initial description, a number of studies have focused on different aspects of this lesion, attempting to explain its distinctive biological behaviour. In this review the authors address the main genetic and epigenetic alterations reported on this tumour. Although most of the knowledge on this field is not being used in the clinical practice, some perspectives of translational studies are discussed. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009653 Mon, 05 Oct 2009 00:00:00 +0100 3009653 http://www.medworm.com/index.php?rid=3009646&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008896%2Fabstract%3Frss%3Dyes We present a clinicopathologic and immunohistochemical study of 21 Chinese patients with oncocytoma of salivary gland origin, a rare benign tumour composed exclusively of large epithelial cells with eosinophilic granular cytoplasm (oncocytes). The median age was 60.1years with a male predominance (67%). All the tumours occurred in the parotid except one in the palate. A painless mass was the most common feature, although intermittent pain was complained of in four cases. All the patients were treated by superficial parotidectomy, with no recurrence or metastasis. Histologically, most tumours displayed an encapsulated nodular growth pattern, but one case presented with an aggressive growing tendency. Typical oncocytes were observed in all cases, with one clear cell variant found. The oncocy... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009646 Mon, 05 Oct 2009 00:00:00 +0100 3009646 http://www.medworm.com/index.php?rid=3009645&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008781%2Fabstract%3Frss%3Dyes Summary: Oral examination alone cannot always distinguish benign from premalignant and malignant lesions, thereby resulting in delayed patient referral and poorer prognosis. Thus, any non-invasive technology which highlights oral premalignant and malignant lesions in a highly sensitive and specific manner will undoubtedly aid clinicians in early diagnosis and treatment of these conditions. The aim of this study was to assess the efficacy of acetic acid mouthwash and diffused light illumination (Microlux/DL™) as a diagnostic aid in the visualisation of oral mucosal lesions and its ability to highlight malignant and potentially malignant lesions. Fifty patients referred for assessment of an oral white lesion were initially examined under routine incandescent operatory light. The location, ... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009645 Mon, 05 Oct 2009 00:00:00 +0100 3009645 http://www.medworm.com/index.php?rid=3009648&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008793%2Fabstract%3Frss%3Dyes Conclusion: Colonization of oral mucosa with a non-C. albicans species such as C. glabrata, capable of producing carcinogenic amounts of ACH from both ethanol and glucose, may contribute to the development of oral cancer. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009648 Wed, 30 Sep 2009 00:00:00 +0100 3009648 http://www.medworm.com/index.php?rid=2821692&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008987%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821692 Wed, 23 Sep 2009 16:14:46 +0100 2821692 http://www.medworm.com/index.php?rid=2821675&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000621%2Fabstract%3Frss%3Dyes Oral Oncology continued to make very good progress in 2008, as shown by key indicators which include:Oral Oncology remains in the top 10 journals of the ‘Dentistry, Oral Surgery and Medicine’ category for Impact Factors. The 2007 Impact Factor of 2.569 relates to the journal in 2005 and 2006 and we are confident of yet a further increase in the impact factor for 2008, due soon. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821675 Wed, 23 Sep 2009 16:14:39 +0100 2821675 http://www.medworm.com/index.php?rid=2821663&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008951%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821663 Wed, 23 Sep 2009 16:14:37 +0100 2821663 http://www.medworm.com/index.php?rid=3009659&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008513%2Fabstract%3Frss%3Dyes Summary: The classification system for malignant salivary gland tumors (MST) is largely dependent on its histogenesis. The histogenesis is uncertain but the “bicellular theory of origin” has been accepted by most and states that malignant transformation of reserve cells from either the intercalated or excretory duct are responsible for the development of MST. Cyclooxygenase-2 (cox-2), a potential molecular marker for MST, was analyzed on a series (n=56) of MST with the aim of determining the morphological MST subtypes capable of cox-2 overexpression and correlating its expression with histogenesis.Fifty six primary major and minor gland MST were stained with anti-cox-2 antibody and rated with a combined score that added a scale of intensity to the percentage of tumor cells that overexp... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009659 Thu, 03 Sep 2009 00:00:00 +0100 3009659 http://www.medworm.com/index.php?rid=3009643&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883750900863X%2Fabstract%3Frss%3Dyes In this study, we evaluate the relationships between p53 over expression/mutations, bcl2 expression and ploidy status in a retrospective cohort of responder and non-responder carcinoma of the larynx patients.Tissue samples from 22 patients with histopathologically confirmed carcinoma of the larynx and matched for age, stage, node status and treatment regimen, were analysed from our tissue biorepository. Differences in the above molecular markers were analysed between the responders and non-responders to conventional treatment. p53 and bcl2 over expression was checked by IHC and p53 mutation by PCR and direct sequencing. DNA ploidy and S-phase fractions were also analysed. Chi square analysis was used to identify changes in proportions of these markers in responders and non-responders and l... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009643 Thu, 03 Sep 2009 00:00:00 +0100 3009643 http://www.medworm.com/index.php?rid=3009661&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008550%2Fabstract%3Frss%3Dyes Summary: Several authors have cited liver cirrhosis as a risk factor for surgery but no study performed statistical correlation between flap outcome and severity of liver cirrhosis in patients with head and neck cancer. We performed a retrospective analysis of 3108 patients who underwent free tissue transfer after head and neck cancer ablation between January 2000 and December 2008. Liver cirrhosis was identified in 62 patients. Forty-two patients (67.7%) were classified as having Child’s class A cirrhosis, seventeen (27.4%) as having class B, and three (4.9%) as having class C cirrhosis. The overall complete flap survival rate was 90.3% (56/62). The flap-related complications of patients with Child’s class A, B, and C were 38.1% (16/42), 47.1% (8/17), and 100% (3/3), respectively and ... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009661 Wed, 02 Sep 2009 00:00:00 +0100 3009661 http://www.medworm.com/index.php?rid=3009663&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883750900877X%2Fabstract%3Frss%3Dyes In this study, we showed that esculetin significantly suppressed the growth of oral cancer SAS cells in a dose-dependent manner. DNA content flow cytometry and TUNEL assay revealed that esculetin induced cell cycle arrest and apoptosis. Western blotting showed esculetin increased DR5 protein expression and activated caspase-8, which differed from previous studies conducted in other cell types. Furthermore, treatment with esculetin significantly increased TRAIL-induced apoptosis in SAS cells and the TRAIL-sensitizing effect was blocked by DR5/Fc chimera protein. Our results indicate that esculetin enhances TRAIL-induced apoptosis primarily through upregulation of DR5. Combination of esculetin and TRAIL may be a novel treatment strategy for oral cancers. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009663 Tue, 01 Sep 2009 00:00:00 +0100 3009663 http://www.medworm.com/index.php?rid=3009662&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008768%2Fabstract%3Frss%3Dyes Summary: To evaluate treatment outcomes and the role of primary definitive surgery for T1–2, clinically N0 oropharyngeal squamous cell carcinoma (OPSCC) patients, we performed a retrospective analysis of 46 consecutive cases treated primarily by surgery and/or postoperative radiotherapy at Yonsei University between May 1992 and December 2006. Twelve patients were T1 and 34 were T2. The most common location was the tonsil (54%), followed by the soft palate (19%), the base of the tongue (BOT) (15%) and the posterior wall (12%). Occult lymph node metastasis was noted in 12 cases (26%). Seventeen patients (37%) received adjuvant radiotherapy. The 5-year disease-specific survival rate (DSSR) was 83%: 100% for clinical stage I (T1N0) and 74% for clinical stage II (T2N0). The 5-year DSSR of pat... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009662 Tue, 01 Sep 2009 00:00:00 +0100 3009662 http://www.medworm.com/index.php?rid=3009644&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008756%2Fabstract%3Frss%3Dyes Summary: The aim of this study was to estimate the relations between hypoxia inducible factor-1α (HIF-1α) gene polymorphisms, C1772T and G1790A, to the susceptibility and clinicopathological status of oral cancer. A total of 521 subjects, including 347 controls and 174 oral cancer patients, were recruited in this study and subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze the impact of these two polymorphic variants on oral cancer. A significant association between oral cancer susceptibility and G1790A polymorphism was demonstrated since individuals with heterozygotes, that is GA, had a higher risk for oral cancer, compared to GG genotypes after adjusting for other confounders (AOR=3.31; 95%CI=1.27–8.61). Compared to individuals with ... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009644 Tue, 01 Sep 2009 00:00:00 +0100 3009644 http://www.medworm.com/index.php?rid=2905964&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008641%2Fabstract%3Frss%3Dyes In 2008, an Editorial defined the various parameters by which the progress and impact of Oral Oncology could be affirmed to that date. Oral Oncology has since seen continued real progress. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905964 Mon, 31 Aug 2009 23:00:00 +0100 2905964 http://www.medworm.com/index.php?rid=2905959&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008446%2Fabstract%3Frss%3Dyes Summary: The aim of this study was to evaluate the ability of computer assisted designed (CAD) synthetic hydroxyapatite and tricalciumphosphate blocks to serve as precise scaffolds for intramuscular bone induction in a rat model. A central channel to allow for vessel pedicle or nerve integration was added. Natural bovine hydroxyapatite blocks served as controls to evaluate and compare biocompatibility of the new matrices.Individually designed 3D-printed rounded and porous hydroxyapatite (HA) and tricalcium phosphate (TCP) blocks were placed in pouches in the Musculus latissimus dorsi in 12 Lewis rats bilaterally. Bovine hydroxyapatite blocks with and without a central channel served as controls. Simultaneously, 200μg rhBMP-2 in 1ml sodium chloride was injected on both sides. For 8weeks, b... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905959 Mon, 31 Aug 2009 23:00:00 +0100 2905959 http://www.medworm.com/index.php?rid=2746196&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008343%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746196 Mon, 31 Aug 2009 11:45:30 +0100 2746196 http://www.medworm.com/index.php?rid=2746164&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883750900829X%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746164 Mon, 31 Aug 2009 11:45:13 +0100 2746164 http://www.medworm.com/index.php?rid=3009658&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008458%2Fabstract%3Frss%3Dyes In this report, we examined the effects of Prx I on cell sensitivity to cisplatin-induced apoptosis. Mouse embryo fibroblasts (MEFs) derived from Prx I-deficient mice showed increased cisplatin-induced apoptosis compared with wild-type MEFs. Cisplatin treatment also led to increased activation of p38 MAPK and JNK, and reduced ERK phosphorylation in Prx I-deficient MEFs compared with wild-type MEFs. Furthermore, JNK- and ERK-specific inhibitors protected the Prx I-deficient MEFs from cisplatin-induced apoptosis, but Prx I-deficient MEFs remained more sensitive than wild-type MEFs when treated with a p38 MAPK-specific inhibitor. These findings indicate that Prx I modulates the cisplatin-evoked activation of MAPKs that lead to apoptosis, and Prx I may thus represent a useful target as a prote... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009658 Wed, 19 Aug 2009 00:00:00 +0100 3009658 http://www.medworm.com/index.php?rid=3009642&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008537%2Fabstract%3Frss%3Dyes In this study, [18F]-fluoro-3′-deoxy-l-thymidine ([18F]FLT), a proliferation tracer is compared with 2-[18F]-fluoro-2-deoxy-d-glucose ([18F]FDG).Patients with primary laryngeal cancer, scheduled to undergo radiotherapy were included in this study. Patients underwent both [18F]FLT-PET and [18F]FDG-PET shortly before radiotherapy. Ten patients underwent [18F]FLT-PET and [18F]FDG-PET 2–3months after radiotherapy. Scans were analyzed visually for areas of increased tracer uptake. The standardized uptake value (SUV) was measured as a semi-quantitative value of tracer uptake.Fourteen patients, all male, were included in this study. Both [18F]FLT-PET and [18F]FDG-PET showed increased tracer uptake in 12 out of 14 patients (86%). [18F]FDG uptake was significantly higher than [18F]FLT uptake (S... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009642 Wed, 19 Aug 2009 00:00:00 +0100 3009642 http://www.medworm.com/index.php?rid=2905966&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008434%2Fabstract%3Frss%3Dyes Summary: Of malignant tumours with a propensity to invade the perineural space, adenoid cystic carcinoma of the salivary glands is perhaps the best known. However, it is not known if microscopic evidence of perineural invasion has true prognostic significance in adenoid cystic carcinoma. A review of the available data, which is the aim of this article, reveals the issue is not straightforward. There is a plethora of conflicting data which, on balance, suggest the answer is indeed in the affirmative, particularly if the nerve involved is above a certain size, or “named”. Even if the data are equivocal, many head and neck surgeons and oncologists take account of histologically proved perineural invasion when planning treatment for adenoid cystic carcinoma. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905966 Tue, 18 Aug 2009 23:00:00 +0100 2905966 http://www.medworm.com/index.php?rid=2905965&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008616%2Fabstract%3Frss%3Dyes Summary: Accurate staging at the time of the diagnosis of head and neck squamous cell carcinoma (HNSCC) is critical for selection of the appropriate treatment strategy. Therefore, optimizing pre-treatment imaging in the diagnostic work-up is of great importance. CT and MRI are the corner stones of diagnostic work-up. Technical improvements will increase the value of these techniques even further. PET and PET-CT became a standard imaging techniques for HNSCC patients. It may be helpful for the detection of occult primary tumours, but its sensitivity for the detection of occult lymph node metastases is too low. Alternatively, the sentinel node procedure may be sufficiently accurate to avoid elective treatment of the neck. Screening for distant metastases should be performed only in HNSCC pat... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905965 Tue, 18 Aug 2009 23:00:00 +0100 2905965 http://www.medworm.com/index.php?rid=2746174&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008549%2Fabstract%3Frss%3Dyes It is widely accepted that any debate which advocates a harm reduction strategy which, itself incorporates smokeless tobacco within its armament, will divide the tobacco control community. The deep wounds left by the tobacco industry and the wide felt suspicion towards their intentions are such that, their recently announced strategy to promote smokeless tobacco as an alternative to smoking cigarettes, has been met with negative rebuttal. As with any of the tobacco industry’s new ventures, the latter is being dismissed as either a cynical move, by them, to introduce a new section of the population to tobacco or an attempt to distract the tobacco control lobby as it moves to create a tobacco free society. Opinion is divided and strong feelings are being expressed in both of the tobacco co... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746174 Tue, 18 Aug 2009 23:00:00 +0100 2746174 http://www.medworm.com/index.php?rid=3009660&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008525%2Fabstract%3Frss%3Dyes Summary: Oral squamous cell carcinoma (OSCC) is characterized by high mortality rate and rising incidence. The aim of this study was to examine the methylation of particular tumor suppressor genes promoters in OSCC and to correlate the methylation status with the tumor-host features and patients survival. The genes selected for our investigation are involved in key cellular processes of malignant transformation, including cell cycle control (p16), apoptosis (Death Associated Protein Kinase, DAPK), Wnt signaling (Adenomatous Polyposis Coli, APC), cell–cell adhesion (E-cadherin, E-cad), and DNA repair (O6-methylguanine-DNA methyltransferase, MGMT, Werner syndrome gene, WRN). In 77 patients with OSCC, hypermethylation was determined by nested methylation-specific PCR method. Methylation of ... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009660 Mon, 10 Aug 2009 00:00:00 +0100 3009660 http://www.medworm.com/index.php?rid=3009657&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008264%2Fabstract%3Frss%3Dyes This study identified amplifications of CCND1 and CTTN by quantitative (Q)-PCR analysis in 50% and 45% of OSCC samples, respectively. Co-amplification of both genes was identified in 20% of tumors. Higher CTTN expression was associated with nodal metastasis of the OSCC, while the amplification of CCND1 was identified in 28% of oral brushed samples from areca chewers, who form a high risk group for OSCC. This study confirms the importance of alterations in CCND1 and CTTN with respect to areca-associated OSCC, and demonstrates that there is an early occurrence of amplification of these genes in the risk population. The non-invasive brushing sampling method coupling with Q-PCR analysis needs to be validated for use as an early detection system for gene copy changes, which should aid oral canc... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=3009657 Mon, 10 Aug 2009 00:00:00 +0100 3009657 http://www.medworm.com/index.php?rid=2905972&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008252%2Fabstract%3Frss%3Dyes Summary: Recently, it has been reported that bacterial infections play an important role in the development of cancers of the upper aero digestive tract. To examine the influence of bacterial infections on oral cancer, human oral carcinoma T3M-1 cells were treated with lipopolysaccharide (LPS) for 24h as a model of infection. The LPS treatment increased the mRNA expression of CXCR4 and invasiveness in T3M-1 cells stimulated with CXCL12.The Rho family of small guanosine triphosphatases regulates the dynamics of the actin cytoskeleton that underlie cellular functions such as cell shape changes, migration and polarity. In T3M-1 cells treated with LPS and stimulated with CXCL12, Rac and Cdc42 were activated and caused an increase in the development of filopodia. The present findings suggest th... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905972 Sun, 09 Aug 2009 23:00:00 +0100 2905972 http://www.medworm.com/index.php?rid=2905971&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008240%2Fabstract%3Frss%3Dyes The objective of the present analysis was to define the potential value of 2-[18F]fluoro-2-deoxy-d-glucose (18FDG) uptake in the tumor measured by positron emission tomography (PET) in predicting patients’ outcome in the clinical course of OSCC. In this respect, a clinically well-defined cohort of 79 patients with primary OSCC was retrospectively evaluated. 18FDG uptake in the primary tumor site was quantified by calculation of the maximum standardized uptake values (SUVmax). Subsequent statistical analyses found, that 18FDG uptake of the primary tumor was significantly higher in stage T3/T4 vs. T1/T2 (p (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905971 Sun, 09 Aug 2009 23:00:00 +0100 2905971 http://www.medworm.com/index.php?rid=2905969&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008239%2Fabstract%3Frss%3Dyes Summary: The aim of this study was to evaluate the long-term quality of life (QoL) in survivors with oropharyngeal carcinoma (OC) treated with surgery and postoperative radiotherapy (PORT) versus concurrent chemoradiation (CRT) using the European Organization for Research and Treatment of Cancer QoL Questionnaires. The study group consisted of 57 patients. The scores for physical (P=0.043) and social (P=0.036) functioning were significantly more favorable in the chemoradiation group. Surgical patients showed statistically higher problems with fatigue (P=0.047), pain (P=0.027), swallowing (P=0.042), social eating (P=0.038) and social contact (P=0.002). CRT group reported significantly greater problems with teeth (P=0.049), open mouth (P=0.036), dry mouth (P=0.022) and sticky saliva (P=0.044... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905969 Sun, 09 Aug 2009 23:00:00 +0100 2905969 http://www.medworm.com/index.php?rid=2905961&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008628%2Fabstract%3Frss%3Dyes In conclusion, our findings indicated that VX2-induced rabbit buccal carcinomas could be a potential cancer model for human buccal mucosa squamous cell carcinoma. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905961 Sun, 09 Aug 2009 23:00:00 +0100 2905961 http://www.medworm.com/index.php?rid=2905960&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883750900846X%2Fabstract%3Frss%3Dyes In conclusion, normal HBP stem/stromal cells provide a potential avenue for future experimental trials of cancer stem/stem-like cells for treatment of buccal SCC. In vitro, we may detect the sequential changes of normal HBP stem/stromal cells during multistep oral carcinogenesis or the alternations of these cells upon irradiation treatment and/or chemotherapy. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905960 Sun, 09 Aug 2009 23:00:00 +0100 2905960 http://www.medworm.com/index.php?rid=2746173&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008422%2Fabstract%3Frss%3Dyes Oral squamous cell carcinoma (OSCC) is associated with high morbidity and mortality which is due, at least in part, to late detection. Precancerous and cancerous oral lesions may mimic any number of benign oral lesions and recently oral cytology has been investigated as an adjunct clinical tool in the assessment of these lesions. The purpose of the present study was to compare the usefulness of ploidy analysis after Feulgen stained cytological thin-prep specimens with incisional biopsy and histo-pathological examination. Analyses of the cytological specimens were undertaken utilising virtual microscopy. 100 healthy individuals between 30 and 70 years of age, non-smokers, non-drinkers and not taking any medication, had two cytological specimens collected (buccal mucosa and lateral margin of... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746173 Sun, 09 Aug 2009 23:00:00 +0100 2746173 http://www.medworm.com/index.php?rid=2905976&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509007842%2Fabstract%3Frss%3Dyes Summary: Multidrug resistance (MDR) is a major barrier for chemotherapy of many cancers. Mdr-1 plays a key role in the development of MDR as extensively verified. However, the role of Raf-1 overexpression in the development of multidrug resistance in human squamous carcinoma (KBv200) cells remains largely unknown. The aim of this study was to investigate the correlation of Raf-1 overexpression with the development of multidrug resistance in KBv200 cells. Furthermore, we explored the reversal effect of Raf-1 siRNA transfection and Raf-1/Mdr-1 siRNAs co-transfection on the multidrug resistance of KBv200 cells and potential mechanism of reversing the multidrug resistance. MTT and flow cytometry assay were used to investigate the reversal effect of single transfection with either Raf-1 or Mdr-... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905976 Thu, 23 Jul 2009 23:00:00 +0100 2905976 http://www.medworm.com/index.php?rid=2905968&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509007970%2Fabstract%3Frss%3Dyes Conclusion: This study revealed differences in information needs between diagnosed patients and surgically treated oral cavity cancer patients. Results suggest that healthcare professionals should design a protocol to guide development of a comprehensive pre- and postoperative information package to be given to these patients. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905968 Thu, 23 Jul 2009 23:00:00 +0100 2905968 http://www.medworm.com/index.php?rid=2905962&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509007994%2Fabstract%3Frss%3Dyes In this study, we verified the identity of CAL 27 cells by using by short tandem repeat analysis. Then, we performed tumor formation assay, HE staining and immunohistochemistry assay to further study the growing characteristics and histopathological diagnosis of CAL 27 xenografts. Our results showed that CAL 27 xenografts grew slowly in vivo with vesicle formation at both the surfaces and deeper areas of the tumors. The CAL 27 xenografts were then diagnosed as oral adenosquamous carcinomas. Thus CAL 27 appears to be an oral adenosquamous carcinoma cell line. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905962 Thu, 23 Jul 2009 23:00:00 +0100 2905962 http://www.medworm.com/index.php?rid=2746177&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000517%2Fabstract%3Frss%3Dyes In conclusion, these retrospective results confirm the statement that DA is a variation among ameloblastomas. DA present clinicoradiographic and histologic distinct features, when compared with “conventional ameloblastomas”. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746177 Thu, 23 Jul 2009 23:00:00 +0100 2746177 http://www.medworm.com/index.php?rid=2821681&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000529%2Fabstract%3Frss%3Dyes Summary: The purpose of the study was to investigate the indications and treatment results of intralesional injection of Pingyangmycin for vascular malformations in oral and maxillofacial regions. Between June 2002 and July 2007, 297 patients with oral and maxillofacial vascular malformations (except venular malformation and arteriovenous malformation) were treated with percutaneous injection of Pingyangmycin in our department. There were 159 males and 138 females aged from 8months to 72years (mean age 20.6years). The types of the disease included 98 lymphatic malformations (66 microcystic and 32 macrocystic malformations), 179 venous malformations, and 20 mixed lymphatic–venular or venous malformations. The lesions were located in the oral and maxillofacial and head and neck regions, an... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821681 Wed, 22 Jul 2009 23:00:00 +0100 2821681 http://www.medworm.com/index.php?rid=2821674&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509007982%2Fabstract%3Frss%3Dyes The objectives of this study were (1) to investigate expression of pan-Akt and its phosphorylated form (p-Akt), Akt1, and Akt2 in oral squamous cell carcinoma (OSCC) specimens (n=20) by immunohistochemistry, and (2) to determine mRNA expression of three Akt isoforms, including Akt1, Akt2, and Akt3, as well as their respective proteins, in five oral cancer cell lines and normal human oral keratinocytes (HOKs) by RT-PCR and Western blot assays. The results show that pan-Akt was expressed in 80% of OSCC cases, while Akt1, Akt2, and p-Akt were expressed in all OSCC cases. An intense expression of p-Akt at the invasive fronts of some OSCC samples was observed. Consistent with the immunohistochemical findings, p-Akt and Akt2 were overexpressed in all oral cancer cell lines in comparison with HOK... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821674 Wed, 22 Jul 2009 23:00:00 +0100 2821674 http://www.medworm.com/index.php?rid=2821672&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509007829%2Fabstract%3Frss%3Dyes Summary: Oral squamous cell carcinoma is the sixth most common cancer in the world and the seventh most common cancer in Vietnam. The RAS and PI3K-AKT signaling pathways play an important role in oral carcinogenesis. Our previous study on PI3K signaling pathway showed the absence of PIK3CA and PTEN gene mutations in Vietnamese oral cancer. We thus hypothesized that the RAS could be more likely activated as an upstream effector. However, the status of RAS mutations in Vietnamese oral cancer had not been studied. In the present study, Fifty six primary tumor DNA samples were screened for mutations of hot spots in exons 1 and 2 of H-RAS and a part of the samples for exon 7 of ERK2 gene in which we previously reported a mutation in an OSCC cell line. The H-RAS mutations were detected in 10 of ... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821672 Wed, 22 Jul 2009 23:00:00 +0100 2821672 http://www.medworm.com/index.php?rid=2622973&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008069%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2622973 Wed, 22 Jul 2009 10:38:03 +0100 2622973 http://www.medworm.com/index.php?rid=2622946&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509008021%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2622946 Wed, 22 Jul 2009 10:37:52 +0100 2622946 http://www.medworm.com/index.php?rid=2905977&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509007854%2Fabstract%3Frss%3Dyes Summary: New chemotherapeutic strategy should be investigated to enhance clinical management in salivary gland adenoid cystic carcinoma (ACC). Recently, sulforaphane (SFN), as a natural compound from cruciferous vegetables exhibits a potent anti-cancer activity in various tumor cells, but remains uncertain in ACC cells. The present study examined whether SFN suppresses proliferation and in ACC cells, if so, the possible molecular targets would be further investigated. Cell survives, apoptosis, cell cycle progression and molecular targets were identified by multiple detecting techniques, including trypan blue dye exclusion assay, electron microscopy, AO/EB staining, flow cytometry and immunoblotting in human lung high metastasis cell line of salivary gland adenoid cystic carcinoma (ACC-M). ... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905977 Wed, 08 Jul 2009 23:00:00 +0100 2905977 http://www.medworm.com/index.php?rid=2821671&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509007805%2Fabstract%3Frss%3Dyes Summary: Single agent epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) have demonstrated reproducible response rates of 5–15% in treatment of squamous cell carcinomas of the head and neck (SCCHN). The subset of patients that benefits most from these agents remains unknown. We reviewed individual patient data from five clinical trials of erlotinib, lapatinib, or gefitinib to determine if there are clinical characteristics that are associated with clinical benefit defined as complete response (CR), partial response (PR), and stable disease (SD) >4months. Secondary endpoints included progression-free survival (PFS) and overall survival (OS). Three-hundred and nineteen subjects were included. Observed responses were: 1% CR, 6% PR, 24% SD >4months, 18% SD (Source: Oral... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821671 Tue, 07 Jul 2009 23:00:00 +0100 2821671 http://www.medworm.com/index.php?rid=2905974&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509001432%2Fabstract%3Frss%3Dyes Summary: Polyaromatic hydrocarbons, including benzo[a]pyrene (BP), are major tobacco carcinogens. Their carcinogenic effects require metabolic activation by cytochrome p450 (CYP) enzymes. Relative CYP isoform expression is related to tissue-specific tobacco-related squamous cell carcinoma (SCC) susceptibility. There have been conflicting reports regarding relative CYP1A1 and CYP1B1 oral expression, and information regarding CYP1B1 expression in oral tissues is limited. To quantify BP- and tobacco-induced CYP1A1 and CYP1B1 expression in oral SCC cells and oral mucosa. Study Design: Real-time qPCR was performed to measure (1) BP-induced CYP1A1 and CYP1B1 mRNA expression in seven oral/other head and neck SCC cell lines (2) CYP1A1 and CYP1B1 mRNA expression in gingiva from 22 smokers and 24 no... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905974 Thu, 02 Jul 2009 23:00:00 +0100 2905974 http://www.medworm.com/index.php?rid=2821673&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509007830%2Fabstract%3Frss%3Dyes Summary: The purpose of this study was to evaluate the prognostic influence of various subtypes of tumour infiltrating lymphocytes (TIL) in head and neck cancer, in particular the potential influence of regulatory T cells (Treg) in relation to different treatment modalities was addressed.A total of 115 patients with squamous cell carcinoma of the oro- and hypopharynx were selected. A low-risk group of 62 patients with early disease was treated by primary surgery followed by external radiotherapy. A high-risk group of 53 inoperable patients with advanced disease was treated by primary radiochemotherapy. Two-hundred and forty biopsy samples were evaluated by use of the tissue-micro-array technique employing the following markers: CD3, CD4, CD8, CD20, CD68, FOXP3, Granzyme B.In the low-risk g... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821673 Thu, 02 Jul 2009 23:00:00 +0100 2821673 http://www.medworm.com/index.php?rid=2905975&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509007040%2Fabstract%3Frss%3Dyes Summary: Salivary gland carcinomas (SGCs) are rare tumors encompassing a wide spectrum of histologic/biologic entities. Standard non-surgical treatments are ineffective in case of advanced disease. Our aim was to analyze SGCs deregulation gene profiles that could become target for innovative treatment options.Samples from 139 patients with primary, recurrent and/or metastatic SGCs were investigated by immunohistochemistry for protein encoded by tyrosine kinases receptors (TKRs) i.e. c-kit, HER2, EGFR and hormonal receptors, i.e. androgen (AR), estrogen (ER) and progesterone receptors (PgR). In 26 cases, the HER2 immunohistochemical analysis was complemented by fluorescence in-situ hybridization analysis.EGFR was the most expressed TKRs (71%) and it was found across all histotypes.c-Kit exp... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905975 Wed, 01 Jul 2009 23:00:00 +0100 2905975 http://www.medworm.com/index.php?rid=2905967&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509007787%2Fabstract%3Frss%3Dyes This study suggests that RT is neither a risk for SPT induction nor increases the relative diagnostic time delay of upper aero-digestive tract SPTs. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905967 Wed, 01 Jul 2009 23:00:00 +0100 2905967 http://www.medworm.com/index.php?rid=2821670&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509007052%2Fabstract%3Frss%3Dyes Summary: Histone deacetylases (HDACs) inhibitors induce cell growth arrest and apoptosis in a wide variety of tumor cells. The purpose of this study was to evaluate the effects of trichostatin A (TSA), one of the HDACs inhibitors, on proliferation and apoptosis of oral squamous cell carcinoma cells. Exposure of Tca83 cells (established from human tongue squamous cell carcinoma) to TSA resulted in cell growth inhibition and apoptosis in a dose-dependent manner as measured with MTT (3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) assay and DAPI (4′6′diamidino-2-phenylindole dihydrochloride) staining. Western blot showed that both total PTEN and membrane-bound PTEN were induced by TSA treatment, whereas phosphorylation level (Ser 473) of AKT was correspondingly down-regulated... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821670 Wed, 01 Jul 2009 23:00:00 +0100 2821670 http://www.medworm.com/index.php?rid=2486082&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883750900133X%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2486082 Thu, 25 Jun 2009 07:20:04 +0100 2486082 http://www.medworm.com/index.php?rid=2486060&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509001298%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2486060 Thu, 25 Jun 2009 07:20:04 +0100 2486060 http://www.medworm.com/index.php?rid=2821682&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000542%2Fabstract%3Frss%3Dyes Summary: Oral cancer represents a considerable health problem with more than 10,000 new cases each year in Germany. Nevertheless, little information is available on the knowledge of dentists and the public on oral cancer. This project aims at investigating the knowledge and opinions of dentists via a questionnaire. The present article describes the translation process of an internationally accepted instrument into German. The translation was carried out by the Mapi Research Institute, Lyon, France. The translation procedure followed an established linguistic validation process, consisting of the conceptual analysis of the source instrument, a forward and backward translation, the clinicians’ review, proofreading, and the finalization. The institute identified nine cultural adaptations. A... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821682 Tue, 09 Jun 2009 23:00:00 +0100 2821682 http://www.medworm.com/index.php?rid=2746171&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509001092%2Fabstract%3Frss%3Dyes Summary: We evaluated the effect of expressing the cell cycle regulator cdk2ap1 in epithelial or stromal cell compartments to reduce SCC growth in vitro and in vivo. Cell-autonomous and/or non-cell-autonomous expression of cdk2ap1 reduced tumor growth and invasion and altered cell cycle, adhesion, invasion, angiogenesis, and apoptotic gene expression, as assessed by several in vitro phenotype assays, quantitative real-time PCR, and in vivo molecular imaging using a novel three-way xenograft animal model. Our findings suggest that the interactions between cancer cells and fibroblasts that promote abnormal growth can be minimized by expressing cdk2ap1, supporting a novel concept by which tumor/growth suppressor genes can impact tumorigenesis phenotypes from non-cell-autonomous interactions w... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746171 Tue, 09 Jun 2009 23:00:00 +0100 2746171 http://www.medworm.com/index.php?rid=2746168&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000657%2Fabstract%3Frss%3Dyes Summary: Exonuclease 1 (Exo1) is an important nuclease involved in the mismatch repair system that helps to maintain genomic stability, to modulate DNA recombination, and to mediate cell cycle arrest. Potential polymorphisms in Exo1 may alter cancer risks by influencing the repair activity of Exo1. Therefore, we hypothesized that single-nucleotide polymorphisms in Exo1 were associated with the risk of oral cancer. In this hospital-based study, the associations of Exo1 A-1419G (rs3754093), C-908G (rs10802996), A238G (rs1776177), C498T (rs1635517), K589E (rs1047840), G670E (rs1776148), C723R (rs1635498), L757P (rs9350) and C3114T (rs851797) polymorphisms with oral cancer risk in a central Taiwan population were investigated. In total, 680 patients with oral cancer and 680 age- and gender-mat... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746168 Tue, 09 Jun 2009 23:00:00 +0100 2746168 http://www.medworm.com/index.php?rid=2905973&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509001079%2Fabstract%3Frss%3Dyes Summary: Our study demonstrates that staurosporine (STS), a protein kinase inhibitor from Streptomyces sp., induces apoptosis in human papillomavirus positive oral carcinoma cells (KB) in a dose dependent manner. Growth inhibition studies revealed an IC50 value of approximately 100nM. STS induced marked nuclear fragmentation and inter-nucleosomal cleavage compared to untreated cells. It also caused dose dependent disruption of mitochondrial membrane potential and activation of caspase-3, indicating involvement of mitochondria-mediated cell death signaling in KB cell apoptosis. We found time-dependent arrest of the KB cells at G2/M phase of cell cycle. Using fluorescence microscopy, we have further shown that STS treatment disrupts microtubules and reorganizes F-actin after 6h exposure. Tak... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905973 Sun, 07 Jun 2009 23:00:00 +0100 2905973 http://www.medworm.com/index.php?rid=2905970&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509001067%2Fabstract%3Frss%3Dyes This study investigated the current knowledge and practices of general medical practitioners (GMPs) in Ireland regarding the examination of the oral cavity and the detection of oral malignancy and the training they had received at both undergraduate and postgraduate level and since commencing in practice. A questionnaire survey of GMPs in Ireland was conducted. One hundred and fifty four (65.3%) of the practitioners reported regularly examining the oral mucosa of their patients. Almost half of these (n=68) further qualified this response by stating that they only examined the oral mucosa if the patient reported pain in this area or if the patient specifically requested an oral examination for some reason. Eighty one (34.3%) practitioners surveyed felt confident in their ability to detect o... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905970 Sun, 07 Jun 2009 23:00:00 +0100 2905970 http://www.medworm.com/index.php?rid=2905963&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509001080%2Fabstract%3Frss%3Dyes A 51-year-old woman complained of epistaxis, trismus, and pain. She had a prior history of maxillary sinus adenoid cystic carcinoma (ACC) diagnosed 12years before (1996) and treated by radio-chemotherapy with carboplatin-5 fluorouracil. In 2003, a lung metastasis was treated by surgery and adjuvant carboplatin-5 fluorouracil chemotherapy. In 2006, at the moment of clinical complaints, on examination, there was a friable mass locatedaroundthe palate prosthesis. The maxillary sinus and the orbit were involved. On biopsy, there were foci of conventional ACC and zones of undifferentiated carcinoma with focal squamoid differentiation (a and b). The diagnosis was that of ACC with high grade transformation. Subsequently, in 2007 the patient received a treatment by four cycles of cisplatin–docet... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2905963 Sun, 07 Jun 2009 23:00:00 +0100 2905963 http://www.medworm.com/index.php?rid=2821691&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509001055%2Fabstract%3Frss%3Dyes Summary: Matrix metalloproteinase (MMP)-9 and vascular endothelial growth factor (VEGF) are two proteins involved in angiogenesis. In the present study we investigated the association of pretreatment MMP-9 and VEGF serum levels with clinicopathological parameters and outcome in patients with oral squamous cell carcinoma. Pretreatment serum levels of MMP-9 and VEGF were analyzed in 161 patients with use of enzyme-linked immunoassays. Patients with a VEGF serum level higher than the mean serum level (497.04pg/mL) had a significantly shorter overall survival than those with a serum level lower than median (p (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821691 Sun, 07 Jun 2009 23:00:00 +0100 2821691 http://www.medworm.com/index.php?rid=2821689&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883750900089X%2Fabstract%3Frss%3Dyes This study was designed to establish if elevated preoperative levels of serum CRP could predict the prognosis of patients treated with primary surgery for oral squamous cell carcinoma (SCC). Sixty patients with oral SCC who were treated by primary surgery and microvascular free flap reconstruction, were included in the study. The relation between preoperative levels of serum CRP, clinicopathological features and patient prognosis was determined. This study showed using bivariate analysis (p=0.003) and multivariate analysis (p (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821689 Sun, 07 Jun 2009 23:00:00 +0100 2821689 http://www.medworm.com/index.php?rid=2821687&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000669%2Fabstract%3Frss%3Dyes Summary: Few simple clinical measures are available to monitor swallowing performance in head and neck cancer. Water swallow tests (WST) have been used as a part of clinical assessments in neurological dysphagia. The aim of this paper is to evaluate the utility of the 100mL WST in head and neck cancer patients.The 100mL WST was performed on 167 head and neck cancer patients. Measures were compared with respect to tumor site/stage, gender and age. The cohort was compared with published healthy controls.The test was quick to administer with excellent compliance. Patients had significantly poorer swallows than the published control group (mean reduction 1.6mL/s). Function worsened with increased tumor stage and for patients with pharyngeal tumors.The 100mL WST is an effective swallowing perfo... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821687 Sun, 07 Jun 2009 23:00:00 +0100 2821687 http://www.medworm.com/index.php?rid=2821677&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000979%2Fabstract%3Frss%3Dyes This article summarizes different experiences from research groups working in the field of outcome research in head and neck cancer (HNC). It presents information that has been gathered over a number of years, and emphasizes areas where further research is needed. In this context, the importance of interdisciplinary and multi-institutional collaboration is emphasized. There is a substantial need for a standardized description tool to provide a common basic language for outcome research in HNC. The International Classification of Functioning, Disability and Health (ICF), as adopted by the World Health Organization (WHO), and disease-specific ICF Core Sets for HNC are introduced to describe functioning in HNC. Applications of the ICF Core Set for HNC for further research are discussed. (Sour... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821677 Sun, 07 Jun 2009 23:00:00 +0100 2821677 http://www.medworm.com/index.php?rid=2821669&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509001043%2Fabstract%3Frss%3Dyes This study evaluates the role of Pin1 in head and neck squamous cell carcinomas (HNSCCs). Pin1 expression and level of phosphorylation was evaluated by Western blot analysis and 2D-gel-electrophoresis. Pin1 was inhibited with juglone (5-hydroxy-1,4-naphthalenedione) or Pin1 specific siRNA and its influence on cell cycle checkpoint distribution was assessed by FACS analysis. Pin1 overexpression was found in HNSCC tissues and cell lines. 2D-gel-electrophoresis data pointed to Pin1 being hypophosphorylated in HNSCC cells which is consistent with overactivation of this rotamase. Inhibition of HNSCC cells with juglone or Pin1 siRNA induced the cell cycle inhibitor p21WAF1/Cip1 with a concomitant reduction of cells in G2/M and an increased fraction of cells with fragmented DNA. Cell death did no... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821669 Sun, 07 Jun 2009 23:00:00 +0100 2821669 http://www.medworm.com/index.php?rid=2474987&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000815%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2474987 Mon, 01 Jun 2009 04:00:00 +0100 2474987 http://www.medworm.com/index.php?rid=2474966&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000773%2Fabstract%3Frss%3Dyes (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2474966 Mon, 01 Jun 2009 04:00:00 +0100 2474966 http://www.medworm.com/index.php?rid=2821676&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883750900092X%2Fabstract%3Frss%3Dyes Summary: Toxicities associated with head and neck cancer treatment are common events. Despite the fact that many side effects of cancer treatment are now well controlled, some, such as mucositis and salivary gland hypofunction, continue to be almost inevitable outcomes of cancer treatment. Furthermore, improvements in cancer treatment itself as well as new modalities, such as targeted treatments, may be associated with different toxicities. In this review, common toxicities associated with head and neck cancer treatment will be discussed including those reported to occur with targeted therapies. This review also considers the concept of toxicity clusters, risk factors for toxicity (for example genetics) and individualisation of cancer treatment. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821676 Wed, 20 May 2009 23:00:00 +0100 2821676 http://www.medworm.com/index.php?rid=2821665&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000591%2Fabstract%3Frss%3Dyes Summary: Tumor escape from the host immune system has been a major problem in immunotherapy of human malignancies. Human tumors are known to develop escape strategies, which might differ among tumors of the same histology. This suggests that host-tumor interactions create the tumor microenvironment that is unique for every tumor. Recent advances in cancer immunology allow for a better understanding of the mechanisms tumors use to execute immune escape and of the relationship the tumor establishes with immune cells. It is now feasible to obtain an “immune signature” of the tumor, that is to define the genetic, molecular and functional profiles of immune cells in the tumor microenvironment. This knowledge might be critically important for the personalized selection of available therapies... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821665 Wed, 20 May 2009 23:00:00 +0100 2821665 http://www.medworm.com/index.php?rid=2821690&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509001018%2Fabstract%3Frss%3Dyes Summary: Targeting hypoxia-inducible factor-1 (HIF-1) active cells in tumors may be an excellent strategy to improve the outcome of radiation therapy. On the basis of the reported role of YC-1 as a HIF-1 inhibitor with anti-cancer activity, we tested the therapeutic efficacy of YC-1 against radioresistance in vitro. The AMC-HN3 cancer cell line, developed from squamous cell carcinoma of the larynx, was cultured under hypoxic conditions or in the presence of cobalt chloride. Both treatments induced nuclear accumulation of HIF-1α protein. Cells cultured under normoxic or hypoxic conditions with and without YC-1 treatment were irradiated and analyzed using flow cytometry and clonogenic assays. In the absence of YC-1 treatment, irradiation induced a greater cytotoxic effect in normoxic cells ... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821690 Tue, 19 May 2009 23:00:00 +0100 2821690 http://www.medworm.com/index.php?rid=2821688&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000888%2Fabstract%3Frss%3Dyes In this study the threshold was estimated at 44.4%. N0 neck of squamous cell carcinoma of the oral cavity should be observed if the probability of occult metastasis is less than 44.4%. Proper calculation of three probabilities of being cured in each institution will make a decision of the optimal method of clinical N0 neck by using the threshold formula. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821688 Tue, 19 May 2009 23:00:00 +0100 2821688 http://www.medworm.com/index.php?rid=2821686&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000645%2Fabstract%3Frss%3Dyes This study set out to describe patients self-reporting of intimacy and sexual dysfunction following treatment and to explore associations with patient characteristics. Patients treated for primary head and neck squamous cell carcinoma, alive and disease free, were identified from the University Hospital Aintree Head and Neck Cancer database, January 2000 to December 2006. A postal survey with two questions from the European Organisation for Research and Treatment of Cancer Quality of Life questionnaire-Head and Neck 35 (EORTC H&N35) regarding sexuality, a self-designed question about intimacy and the University of Washington quality of life questionnaire Version 4 (UW-QOL v4) was sent to patients in March 2007. There was a 68% response (350/518). One-third of those answering the intimacy a... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821686 Tue, 19 May 2009 23:00:00 +0100 2821686 http://www.medworm.com/index.php?rid=2821685&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883750900061X%2Fabstract%3Frss%3Dyes In this study, we sought to elucidate the underlying pathological and biological mechanisms of the close correlation in OSCC between high FDG-uptake and poor survival. Twenty-three patients who underwent both pretreatment FDG-PET and radical surgery were evaluated. We calculated the maximum standardized uptake value (SUVmax) as FDG-uptake. Tumor thickness and depth of invasion were quantitatively measured. Pathological specimens were immunohistochemically stained with antibodies to glucose transporter-1, E-cadherin, β-catenin, vascular endothelial growth factor (VEGF), VEGF-C and Bcl-2, and their expressions were densitometrically assessed. SUVmax was significantly correlated with both tumor thickness and depth of invasion in simple regression analysis. Patients with SUVmax⩾12 exhibited... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821685 Tue, 19 May 2009 23:00:00 +0100 2821685 http://www.medworm.com/index.php?rid=2821684&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000608%2Fabstract%3Frss%3Dyes Summary: To date there are still no reliable biomarkers for oral potentially malignant disorders (PMDs) to predict the risk of progression to squamous cell carcinoma (SCC). Within a prospective clinical trial of patients with PMDs, DNA content flow cytometry (DNA FCM) was evaluated for 60 PMDs using fresh samples obtained by a dermatological curette. There were 6/42 PMDs without dysplasia, but with DNA aneuploidy, versus 8/18 with both dysplasia and aneuploidy (p=0.02). When the tongue and the buccal mucosa, the two most common sites in the present series of cases were compared, dysplastic PMDs were mainly located on the tongue (p=0.01). Tobacco smokers, who preferentially developed PMDs in the buccal mucosa at a younger age than non-smokers (p=0.002), had fewer dysplastic PMDs than did no... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821684 Tue, 19 May 2009 23:00:00 +0100 2821684 http://www.medworm.com/index.php?rid=2821666&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000906%2Fabstract%3Frss%3Dyes Summary: Cyclooxygenase-2 (COX-2) levels are increased in various tumors, particularly those involving the esophagus, stomach, breast, pancreas, lung, colon, skin, urinary bladder, prostate and head and neck. Nevertheless, the tumorigenic mechanisms of COX-2 overexpression still remain poorly understood and may include mechanisms that may act at different stages of the disease. Thus, the literature shows increasing evidence that overexpression of the COX-2 plays an important role in tumor growth and spread of tumors by interfering with different biological processes such as cell proliferation, cellular adhesion, immune surveillance, apoptosis, and angiogenesis. Furthermore, the expression of COX-2 might shed some light over the physiopathology and clinical behavior of tumors of the head an... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821666 Tue, 19 May 2009 23:00:00 +0100 2821666 http://www.medworm.com/index.php?rid=2746191&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883750900030X%2Fabstract%3Frss%3Dyes In this study, platinum-based chemoradiotherapy provided good local control for oropharyngeal carcinoma. Although acute and late toxicities occurred, they were considered tolerable. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746191 Tue, 19 May 2009 23:00:00 +0100 2746191 http://www.medworm.com/index.php?rid=2746172&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000967%2Fabstract%3Frss%3Dyes To the Editor, The primary involvement of mandible by non-Hodgkin lymphoma (NHL) is a very rare occurrence. In particular, among NHLs of the mandible, the diffuse large B-cell lymphoma (DLBCL) with anaplastic cell features represents an exceptional observation. We observed and thereby reported the case of a 33-year-old man who was referred by his general practitioners to our hospital with a 1-months history of a progressively increasing palpable painful mass in the left mandible region. Past medical history was not remarkable. Physical examination and laboratory evaluation showed no abnormal findings. Ultrasonography demonstrated a solid intraosseous large lesion in the mandible. Panoramic radiography showed surface irregularity of the affected mandible region. An incision biopsy of the l... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746172 Tue, 19 May 2009 23:00:00 +0100 2746172 http://www.medworm.com/index.php?rid=2746170&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000980%2Fabstract%3Frss%3Dyes Summary: Connective tissue growth factor (CTGF) is associated with the onset and progression of fibrosis in many human tissues. Areca nut (AN) chewing is the most important etiological factor in the pathogenesis of oral submucous fibrosis (OSF). We immunohistochemically examined the expression of CTGF protein in 20 cases of OSF and found positive CTGF staining in fibroblasts and endothelial cells in all cases. Western blot analysis showed that arecoline, a main alkaloid found in AN, stimulated CTGF synthesis in a dose- and time-dependent manner in buccal mucosal fibroblasts. Constitutive overexpression of CTGF during AN chewing may enhance the fibrotic activity in OSF and play a role in the pathogenesis of OSF. Pretreatment with NF-κB inhibitor Bay 11-7082, JNK inhibitor SP600125, p38 MAP... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746170 Tue, 19 May 2009 23:00:00 +0100 2746170 http://www.medworm.com/index.php?rid=2746169&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000918%2Fabstract%3Frss%3Dyes Summary: To determine the quality of the information available on the internet in relation to oral cancer.Sites were identified using two search engines (Google and Yahoo), and the search term “oral cancer”. The first 100 consecutive sites in each search were visited and classified. The websites were evaluated for quality of content by using the validated DISCERN rating instrument and the JAMA benchmarks; the existence of the Health on the Net (HON) seal was also registered.The Google search yielded 25,70,000 sites for oral cancer, while Yahoo yielded 6,99,00,000. We reviewed 29 Google websites and 22 Yahoo websites. Based on the JAMA benchmarks, only two sites (6.9%) met the four criteria in the Google search, versus a single site (4.5%) in the Yahoo search. As regards the DISCERN ins... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746169 Tue, 19 May 2009 23:00:00 +0100 2746169 http://www.medworm.com/index.php?rid=2746167&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000633%2Fabstract%3Frss%3Dyes Summary: To determine incidence trends of head and neck squamous cell carcinomas (HNSCC), we analyzed site-specific data collected by The Netherlands Cancer Registry by 15years-of-age categories from 1989–2006. The age-standardized annual incidence trends of all sites taken together showed a significant decrease of 0.6% for males and a significant increase of 1.8% for females. The trend for oropharyngeal carcinoma was most remarkable, with a significant increase of 2.5% and 3.0% per year for males and females, respectively. The incidence of oral carcinoma also significantly increased with a more pronounced effect for females than for males (2.0% vs. 0.5% per year). As for hypopharyngeal cancer, a significant annual increase for females (2.5%) and a stable situation for males was observed... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746167 Tue, 19 May 2009 23:00:00 +0100 2746167 http://www.medworm.com/index.php?rid=2821683&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000554%2Fabstract%3Frss%3Dyes Summary: To investigate the expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and its effects on angiogenesis and lymphangiogenesis in oral carcinoma. Immunohistochemistry was used to study the expression of CEACAM1, LYVE1 and CD31, double-labelling immunofluorescence was used to detect the co-expression of CEACAM1 and LYVE1, and double-labelling immunohistochemistry was performed to observe the co-expression of LYVE1 and CD31 in vessels. Membranous CEACAM1 was expressed in well-differentiated squamous cell carcinoma and cytoplastic CEACAM1 in poorly and moderately differentiated carcinoma (P (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821683 Tue, 12 May 2009 23:00:00 +0100 2821683 http://www.medworm.com/index.php?rid=2821680&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000475%2Fabstract%3Frss%3Dyes Summary: Concomitant chemoradiotherapy is a common treatment for advanced head and neck squamous cell carcinomas (HNSCC). Cisplatin is the backbone of chemotherapy regimens used to treat HNSCC. Therefore, the aim of this study was to identify predictive markers for cisplatin treatment outcome in HNSCC. The intrinsic cisplatin sensitivity (ICS) was determined in a panel of tumour cell lines. From this panel, one sensitive and two resistant cell lines were selected for comparative transcript profiling using microarray analysis. The enrichment of Gene Ontology (GO) categories in sensitive versus resistant cell lines were assessed using the Gene Ontology Tree Machine bioinformatics tool. In total, 781 transcripts were found to be differentially expressed and 11 GO categories were enriched. Tra... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821680 Tue, 12 May 2009 23:00:00 +0100 2821680 http://www.medworm.com/index.php?rid=2746176&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000499%2Fabstract%3Frss%3Dyes This article reviews immunotherapeutic strategies currently in clinical trials or under development for patients with SCCHN. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746176 Tue, 12 May 2009 23:00:00 +0100 2746176 http://www.medworm.com/index.php?rid=2746175&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000463%2Fabstract%3Frss%3Dyes Head and neck cancer includes cancers originating in the oral cavity, the oropharynx, the hypopharynx, and the larynx. Collectively these cancers are among the most common in the world accounting for over 550,000 new cases and over 300,000 deaths per year – with the greatest burden falling upon low- and medium-income countries. Survival for patients with head and neck cancer is poor and there has been limited improvement in the last three decades. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746175 Tue, 12 May 2009 23:00:00 +0100 2746175 http://www.medworm.com/index.php?rid=2746166&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS136883750900058X%2Fabstract%3Frss%3Dyes Summary: The aim of the present study was to evaluate the effect of different irradiation doses after desensitizer application on the onset of initial demineralization of human dentin in situ. The root surfaces of 45 freshly extracted caries-free human molars were cleaned, thereby removing the cementum. From each tooth two root dentin specimens were prepared. The specimens were distributed among the following experimental groups: 0, 0.5, 1, 2 and 5Gy. The irradiation dose was fractionally applied (0.5Gy/day). One dentin specimen of each group was inserted into both buccal aspects of nine intraoral mandibular appliances. On one side the specimens were additionally coated with the desensitizer Hyposen (H). On the other side, the specimens were left untreated (C). The appliances were worn by ... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746166 Tue, 12 May 2009 23:00:00 +0100 2746166 http://www.medworm.com/index.php?rid=2746165&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000578%2Fabstract%3Frss%3Dyes Summary: Head and neck squamous cell carcinoma (HNSCC) is associated with environmental factors, especially tobacco and alcohol consumption. Most of the carcinogens present in tobacco smoke are converted into DNA-reactive metabolites by cytochrome P450 (CYPs) enzymes and detoxification of these substances is performed by glutathione S-transferases (GSTs). It has been suggested that genetic alterations, such as polymorphisms, play an important role in tumorigenesis and HNSCC progression. The aim of this study was to investigate CYP1A1, CYP1A2, CYP2E1, GSTM1, and GSTT1 polymorphisms as risk factors in HNSCC and their association with clinicopathologic data. The patients comprised 153 individuals with HNSCC (cases) and 145 with no current or previous diagnosis of cancer (controls). Genotyping... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746165 Tue, 12 May 2009 23:00:00 +0100 2746165 http://www.medworm.com/index.php?rid=2622953&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000360%2Fabstract%3Frss%3Dyes Summary: Oral dysplasia is a potentially precancerous lesion diagnosed histologically. While the risk of progression is associated with histological grade, it is currently impossible to predict accurately which lesions will progress. More accurate markers predicting progression to cancer would enable the targeting of these lesions for more aggressive treatment and closer follow-up. We have performed a systematic review with pooling of data to assess the evidence for the use of biomarkers in predicting transformation of oral dysplasia into cancer. We systematically searched the Cochrane library, MEDLINE, EMBASE, AMED, Cinahl and the Kings Fund electronic databases using the terms: oral dysplasia, leukoplakia, erythroplakia, biomarkers and genetic markers. The following a priori selection cr... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2622953 Tue, 12 May 2009 23:00:00 +0100 2622953 http://www.medworm.com/index.php?rid=2622951&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000566%2Fabstract%3Frss%3Dyes Summary: The aim of this study was to evaluate feasibility, reliability, validity of the SWAL-QOL (a questionnaire on swallowing problems in daily life), and to define sample size calculations and a clinically relevant cut-off score. One hundred and two patients were treated for cancer of the oral cavity or pharynx and 111 healthy subjects completed the SWAL-QOL and the EORTC H and N35 questionnaire. A randomly selected subset of patients (n=29) completed the SWAL-QOL twice to assess test–retest stability. For the patient sample, data on tumor site (oral or oropharyngeal) and stage (I–IV), treatment modality (surgery, radiation, surgery+radiation, chemoradiation), and presence of a PEG tube were abstracted from medical records. Reliability of the SWAL-QOL was high with high internal co... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2622951 Tue, 12 May 2009 23:00:00 +0100 2622951 http://www.medworm.com/index.php?rid=2622950&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000505%2Fabstract%3Frss%3Dyes Summary: Conventional surgical approaches for tonsillar carcinomas have a great risk for developing treatment-related morbidity. To minimize this morbidity, transoral lateral oropharyngectomy (TLO) using the robotic surgical system was performed, and the efficacy and feasibility of this procedure was evaluated. TLO was performed using the da Vinci surgical robot (Intuitive Surgical, Inc., Sunnyvale, CA). It consists of a surgeon’s console and a manipulator cart equipped with three robotic arms. The surgeon is provided with three-dimensional magnified images from the endoscopic arm and can control two instrument arms for delicate operations from the console. Safe resection of tonsillar carcinoma was possible with the three-dimensional magnified images. When proceeding with resection of th... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2622950 Tue, 12 May 2009 23:00:00 +0100 2622950 http://www.medworm.com/index.php?rid=2821679&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000396%2Fabstract%3Frss%3Dyes Summary: Mutations in PTCH1 gene are responsible for majority of nevoid basal cell carcinoma syndrome (NBCCS) as well as for some related sporadic neoplasms. Odontogenic keratocysts (OKCs) are locally aggressive jaw lesions that may occur in isolation or in association with NBCCS. Mutations of PTCH1 would lead to constitutive activation of Sonic hedgehog (SHH) signaling pathway and result in aberrant cell proliferation. To clarify the role of PTCH1 in OKCs, mutational analysis was undertaken in eight sporadic and four NBCCS-associated OKCs and six PTCH1 mutations were identified in two sporadic and three NBCCS-associated cases. The epithelial cell proliferation as assessed by Ki67 labeling was studied in a total cohort of 62 OKCs (42 sporadic and 20 syndromic cases) with known PTCH1 status... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821679 Thu, 09 Apr 2009 23:00:00 +0100 2821679 http://www.medworm.com/index.php?rid=2821678&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000359%2Fabstract%3Frss%3Dyes In this study, it was confirmed that ameloblastoma cells have a major role in decreased bone formation by secreting sFRP-2 in cell culture model. Though, sFRP-2 has great effect on tumor progression, inhibition of sFRP-2’s anti-bone formation activity and cell proliferative activity may reduce the invasive property of ameloblastoma and possibility of recurrence rate. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821678 Thu, 09 Apr 2009 23:00:00 +0100 2821678 http://www.medworm.com/index.php?rid=2821668&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000451%2Fabstract%3Frss%3Dyes This study investigates whether the gene expression and the immunohistochemical status of FASN, ErbB2, and USP2a correlate with the clinicopathological characteristics of OSCC cases. A strong positive correlation among ErbB2, FASN, and USP2a expression (p=0.001) was observed by qRT-PCR in laser capture microdissected OSCC samples. Perineural infiltration was associated with ErbB2 mRNA expression (p=0.046). The presence of metastatic cervical lymph nodes was associated with FASN (p=0.002), ErbB2 (p=0.001), and USP2a (p=0.006) mRNA levels. ErbB2 staining at the cell membranes was stronger in well-differentiated lesions while a cytoplasmic positivity was found in poorly differentiated tumors. Most of the OSCC (97.06%) that showed a high positivity for FASN were also labeled for ErbB2 at the c... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821668 Thu, 09 Apr 2009 23:00:00 +0100 2821668 http://www.medworm.com/index.php?rid=2821667&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000347%2Fabstract%3Frss%3Dyes Summary: To investigate prospectively the prevalence of high levels of emotional distress and referral rate to psychosocial care in head and neck cancer (HNSCC) patients. Fifty-five consecutive newly diagnosed HNSCC patients were asked to complete the hospital anxiety and depression scale (HADS) and the EORTC QLQ-C30 and H&N35 quality of life questionnaires on a touch screen computer-assisted data collection system on their first visit and during follow-up visit. Sociodemographic, clinical, and quality of life parameters were compared to a high level of distress (HADS score >15). Number of patients with a high level of distress were compared to referral rates to psychosocial care as retrieved from patient hospital files. At time of diagnosis, 18% (10/55) of the patients had a high level of... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821667 Thu, 09 Apr 2009 23:00:00 +0100 2821667 http://www.medworm.com/index.php?rid=2821664&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000487%2Fabstract%3Frss%3Dyes The use of cancer cell-lines derived from human tissues provide a fundamental platform from which our knowledge of the underlying biology of neoplasia is derived. Furthermore, they serve as the basis for the investigation of specific therapeutic strategies towards specific cancer types. This includes the development of novel therapeutic agents or novel combinations of established agents as well as the application of existing therapies with known efficacy against a specific cancer to other cancer types. Typically such preclinical studies involve in vitro cell culture in which response to the agents(s) under investigation is usually measured as a function of inhibition of cell growth. Increasingly the use of in vivo animal models using human cancer xenografts derived from an existing cell-li... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2821664 Thu, 09 Apr 2009 23:00:00 +0100 2821664 http://www.medworm.com/index.php?rid=2746195&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000530%2Fabstract%3Frss%3Dyes To the Editor Thank you very much for Dr. Stephen Sonis’ interest to our recent article published in Oral Oncology. We appreciate the valuable comment raised by Dr. Stephen Sonis and would like to reply as below. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746195 Thu, 09 Apr 2009 23:00:00 +0100 2746195 http://www.medworm.com/index.php?rid=2746190&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000293%2Fabstract%3Frss%3Dyes Summary: Salivary gland carcinomas (SGC) are rare cancers with poor prognosis and limited response to conventional chemotherapy. New strategies based on molecular targeted therapy are needed and the EGFR signaling cascade is considered a possible key pathway for therapeutic molecules. We have analyzed 65 SGC of the main histopathological types for the expression of EGFR and and the mutation status of its downstream effector KRAS. EGFR overexpression (+2, +3) has been identified by immunohistochemistry in 75.4%. KRAS mutation analysis was performed by direct genomic sequencing and revealed a KRAS wildtype in 98.5% except of one adenoid cystic carcinoma with a GGT–GAT transition at codon 12 (Gly12Asp). EGFR overexpression and KRAS wildtype are prerequisites for a successful anti-EGFR thera... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2746190 Thu, 09 Apr 2009 23:00:00 +0100 2746190 http://www.medworm.com/index.php?rid=2622952&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000372%2Fabstract%3Frss%3Dyes HPV has been detected with increased frequency in oral dysplastic and carcinomatous epithelium in comparison with normal oral mucosa. HPV prevalence in oral cavity varies; depending on the methodology used, populations studied and sampling methods. However, many studies suggest a relationship between HPV and OSCC. Oncogenic HPV 16 and 18 are the most frequently found in OSCC. (Source: Oral Oncology) Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2622952 Thu, 09 Apr 2009 23:00:00 +0100 2622952 http://www.medworm.com/index.php?rid=2622949&cid=s_38695_6_f&fid=38695&url=http%3A%2F%2Fwww.oraloncology.com%2Farticle%2FPIIS1368837509000335%2Fabstract%3Frss%3Dyes Summary: To determine whether survival outcomes of younger patients with oral cavity squamous cell cancer (OSCC) differs from older patients in the US. A retrospective cohort study using data from the Surveillance, Epidemiology and End Results (SEER) registry. We studied cases (n=19681) of OSCC diagnosed from 1973 to 1999 and used age cutoffs at 40, 45, 50, and 55years. Control groups of older patients were retrospectively matched on gender, race, cancer subsite, and stage of disease. Survival was estimated using the Kaplan–Meier method. A propensity score matching produced groups with similar distributions of patient and disease characteristics. Between these matched groups, younger patients had a significantly better five-year survival (age 40: 63.4% vs. 80.6%, p (Source: Oral Oncology... Oral Oncology journals http://www.medworm.com/rss/comments.php?id=2622949 Thu, 09 Apr 2009 23:00:00 +0100 2622949