Otolaryngology - Head and Neck Surgery via MedWorm.com

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Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:50 +0100

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Society Page

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:50 +0100

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Editorial Board

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:50 +0100

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Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:50 +0100

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Response to: Huge radicular cyst of the maxilla: Some clinicopathological considerations, from Pitak-Arnnop et al

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:50 +0100

We thank Dr. Poramate Pitak-Arnnop and his colleagues for their comments on our recently published article, titled “Huge radicular cyst,” and for sharing their experiences on tooth-bearing maxillary lesions. (Source: Otolaryngology - Head and Neck Surgery)

Huge radicular cyst of the maxilla: Some clinicopathological considerations

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:50 +0100

Although we would like to congratulate Lee and Byun on their report regarding a gigantic radicular cyst of the maxilla, there are some areas for discussion that can be listed as follows. (Source: Otolaryngology - Head and Neck Surgery)

Mondini dysplasia with paradoxical cerebrospinal fluid rhinorrhea

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:50 +0100

We present a case of a 28-year-old woman diagnosed with Mondini dysplasia presenting as cerebrospinal fluid (CSF) rhinorrhea, treated by postauricular approach. Prior to the study, approval from the institutional review board (Yashoda Academy of Medical Education and Research scientific committee) was obtained. (Source: Otolaryngology - Head and Neck Surgery)

Osteonecrosis of the maxilla associated with the use of bisphosphonates

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:49 +0100

A 62-year-old male patient was referred to our department, suffering from right orbital cellulitis. His medical history revealed the presence of prostate cancer with bone metastases. Over the previous year, he was administered intravenous zolendronate (Zometa; Novartis, Basel, Switzerland). Physical examination ascertained the proptotic right eye with surrounding inflammation and draining fistula beneath the lower eyelid. Oral assessment identified osteonecrosis of the edentulous right hard palate (). The patient denied any surgical therapy and was treated with antibiotics and mouth rinses. The University of Medicine and Pharmacy of Cluj-Napoca Institutional Review Board approved this project. (Source: Otolaryngology - Head and Neck Surgery)

Surgical closure of persistent tracheoesophageal fistulas by esophageal suturing and cranial transposition of the trachea

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:49 +0100

Implantation of a tracheoesophageal voice prosthesis is the gold standard for voice rehabilitation after a total laryngectomy. The incidence of complications generally appears to be greater in patients who have received radiotherapy. Periprosthetic leakage, which persists despite conservative treatment, necessitates surgical treatment. This generally creates a problem that is difficult to solve, especially in the case of patients who underwent radiotherapy, as evidenced by the many surgical approaches described in the literature. (Source: Otolaryngology - Head and Neck Surgery)

Relationship between olfactory function and olfactory neuronal population in C57BL6 mice injected intraperitoneally with 3-methylindole

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:49 +0100

Conclusion: Our study showed that olfactory impairment was correlated with olfactory neuronal population in mice treated with 3-methylindole. The food-finding test would be a useful tool that could be easily performed without special training in the 3-methylindole-treated C57BL6 anosmic mouse model. (Source: Otolaryngology - Head and Neck Surgery)

Effect of pharyngeal packing during nasal surgery on postoperative nausea and vomiting

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:49 +0100

Conclusion: Pharyngeal packing in nasal surgery has no impact on PONV. (Source: Otolaryngology - Head and Neck Surgery)

Prognostic assessments of medical therapy and vestibular testing in post-traumatic migraine-associated dizziness patients

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:48 +0100

Conclusion: Specific prophylactic antimigraine medications were not associated with improved outcomes in PTMAD patients. Initial clinical responses and vestibular test metrics may guide physicians to predict successful outcomes. (Source: Otolaryngology - Head and Neck Surgery)

Publication misrepresentation among otolaryngology residency applicants

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:48 +0100

Conclusion: Misrepresentation of research experience exists among otolaryngology residency applicants. ERAS should develop standardized definitions for publication statuses to help reduce inadvertent misrepresentation. (Source: Otolaryngology - Head and Neck Surgery)

Spanish validation of the University of Washington Quality of Life questionnaire for head and neck cancer patients

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:47 +0100

Conclusion: The Spanish version of the UW-QOL questionnaire appears to be culturally appropriate and psychometrically valid. (Source: Otolaryngology - Head and Neck Surgery)

Correlation of biomarkers in head and neck squamous cell carcinoma

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:47 +0100

Conclusion: There are relationships between protein and functional MRI markers. Future research in this direction may improve our understanding of the cancer micro-environment. (Source: Otolaryngology - Head and Neck Surgery)

Minimally invasive video-assisted thyroidectomy versus conventional thyroidectomy: A cost-effective analysis

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:47 +0100

Conclusion: In a group of matched cohorts, the cost of MIVAT appears to be equal to that of open thyroidectomy. (Source: Otolaryngology - Head and Neck Surgery)

Fracture patterns of the nasal septum

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:47 +0100

Conclusion: Based on our observation, we conclude that fracture patterns of the nasal septum do exist and appear to be related to the amount of force sustained. (Source: Otolaryngology - Head and Neck Surgery)

Correlation of pepsin-measured laryngopharyngeal reflux disease with symptoms and signs

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:46 +0100

Conclusion: Higher levels of pepsin in sputum were associated with higher RSI and RFS in cases of laryngitis. There was no relationship between pepsin levels and RSI in cases of OSA. There were no differences of pepsin concentration in sputum collection methods or in collection timing. (Source: Otolaryngology - Head and Neck Surgery)

How does reflux affect laryngeal tissue quality? An experimental and histopathologic animal study

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:46 +0100

Conclusion: Our findings suggest that reflux induces significant histopathologic changes in larynx mucosa. (Source: Otolaryngology - Head and Neck Surgery)

Systematic review of laryngeal reinnervation techniques

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:45 +0100

Conclusion: Reinnervation is effective in the management of UVFP, although the specific method may be dictated by anatomical limitations. Prospective studies utilizing uniform and consistent outcome parameters are necessary. (Source: Otolaryngology - Head and Neck Surgery)

Otolaryngology and Irish literature: An important medico-literary alliance

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:45 +0100

Abstract: For a comparatively small island, Ireland has made a disproportionately large contribution to world literature in all its aspects. The literary lineage of those who pursue medicine and also write is long and well established. The Irish contribution to world literature in all its aspects is well documented. Less explored, however, is the prominent influence of Dublin-based otolaryngologists in the Irish literary movement at the turn of the last century. Here, we examine two such figures, Sir William Wilde and Oliver St. John Gogarty, and their pivotal roles both professionally and in establishing Ireland on the world's literary stage. During the early part of the 1800s, otology was perceived as a defunct subspecialty that could be adequately managed, without much expertise, in the...

Passion

Otolaryngology - Head and Neck Surgery — Wed, 24 Nov 2010 04:51:44 +0100

One delightful aspect of editing a journal is the occasional letter penned by a non-physician that brings a fresh, new viewpoint to an old subject. Such is the case with the words that follow, setting the stage to discuss how even earwax can invoke passion. (Source: Otolaryngology - Head and Neck Surgery)

Information for Readers

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:34 +0100

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Society Page

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:34 +0100

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Editorial Board

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:34 +0100

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Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:34 +0100

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Correction

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:34 +0100

(Names previously omitted in bold) David Kennedy, MD (moderator); James Palmer, MD; James Stankiewicz, MD; Peter Hwang, MD; Berrylin Ferguson, MD (Source: Otolaryngology - Head and Neck Surgery)

Response to: Scientific independence of authors and of journals to their published articles, from Patrick Froehlich

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:34 +0100

Our two articles initially comprised just one manuscript, which was submitted to Otolaryngology-Head and Neck Surgery for consideration for publication as a separate journal supplement. However, during this process, the editors responded that they could not publish another supplement at the time under consideration, and they asked us to divide the proposed supplement into two original articles to be published in a regular issue of the journal. (Source: Otolaryngology - Head and Neck Surgery)

Scientific independence of authors and of journals to their published articles

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:34 +0100

Two invited articles on lymphatic malformations, by Perkins et al, were of great interest. The authors gave an excellent overview on lymphatic malformations at basic, clinical, and therapeutic levels. (Source: Otolaryngology - Head and Neck Surgery)

Response to: The human external nose and its evolutionary role in the prevention of obstructive sleep apnea, from Mladina et al

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:33 +0100

Thank you for permitting me to respond to the letter from Mladina et al. Before I address their specific concerns, please allow me to begin my letter with a quote from biologist Mark Ridley: “Many organs are adapted to perform more than one function and their adaptations for each are a compromise. If an organ is studied in isolation, as if it were an adaptation for only one of its functions, it may appear poorly designed.” I use this quote to demonstrate that documenting evidence of associations for one function does not exclude other possible functions, as the Mladina letter implies. Furthermore, let me address each of their statements individually. (Source: Otolaryngology - Head and Neck Surgery)

The human external nose and its evolutionary role in the prevention of obstructive sleep apnea

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:33 +0100

Regarding Dr. Stupak's extremely interesting article on the human external nose, published in Otolaryngology–Head and Neck Surgery, we would like to comment on some of the statements. (Source: Otolaryngology - Head and Neck Surgery)

Osteochondroma of the mandibular condyle manifesting only as conductive hearing loss

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:33 +0100

We report herein an unusual case of mandibular condylar OC with conductive hearing loss as the sole clinical symptom. (Source: Otolaryngology - Head and Neck Surgery)

Congenital cholesteatoma originating within the facial nerve canal

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:33 +0100

This study was approved by the institutional research board at UC Irvine (#2008-6516). (Source: Otolaryngology - Head and Neck Surgery)

Oropharyngeal hairy polyps: An uncommon cause of infantile dyspnea and dysphagia

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:32 +0100

This report has been approved by the institutional review board of Kantonale Forschungsethikkommission Luzern (Luzern, Switzerland). (Source: Otolaryngology - Head and Neck Surgery)

Endoscopic vein graft harvest in head and neck reconstruction

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:32 +0100

In modern head and neck reconstruction, free tissue transfer techniques have continued to show excellent utility. In instances in which the free-flap vascular pedicle length is inadequate to traverse the distance necessary for a tension-free anastomosis, interposition vein grafts are used. In our experience, interposition grafts are necessary in approximately two percent of microvascular reconstructions. Concerns about increased free-flap failure related to the use of interposition grafts have been assuaged by retrospective series showing patency rates comparable to primary anastomosis. (Source: Otolaryngology - Head and Neck Surgery)

Seeing the light: Endoscopic endonasal intraconal orbital tumor surgery

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:32 +0100

In this report, we describe the anatomic principles, indications, technical nuances, and limitations of the medial-inferior intraconal EEA to intraorbital tumor surgery, illustrated through a case series of six patients. This approach is ideally suited to benign soft-tissue masses (hemangioma/lymphangioma) in the medial-inferior quadrant of the orbit that do not extend superolaterally. The use of this technique would avoid the technical difficulties in approaching such masses and limit the dissection to the areas bordering the endonasal corridor. (Source: Otolaryngology - Head and Neck Surgery)

Biofilm and persistent inflammation in endoscopic sinus surgery

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:31 +0100

This study examines the association between biofilms and other clinical findings in chronic rhinosinusitis patients.Twenty-four patients with chronic rhinosinusitis who failed medical management underwent endoscopic sinus surgery (ESS). Tissue was collected from the ethmoid sinus and analyzed for the presence of biofilm by hematoxylin and eosin staining, fluorescent in situ hybridization, and confocal scanning laser microscopy. Biofilms were classified as extensive (> 50% of mucosal surface in sample) or present (< 50% of surface). The surgeon remained blinded to the biofilm status of patients until postoperative follow-up was complete.The presence of bacterial biofilm was strongly associated with persistent mucosal inflammation after ESS (53% of biofilm-positive patients vs 0% of biofilm-...

Influence of race and ethnicity on access to care among children with frequent ear infections

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:31 +0100

Conclusion: Racial/ethnic disparities among children with FEI significantly influence health care resource access and utilization. These disparities should be targeted for intervention. (Source: Otolaryngology - Head and Neck Surgery)

The quality of life and health utility burden of recurrent respiratory papillomatosis in children

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:31 +0100

Conclusion: This is the first study to use validated measures of health utility, voice-related quality of life, and psychosocial impact. This information has public health implications, providing essential parameters for accurate modeling studies and cost-utility analysis of future interventions, including different human papilloma virus vaccination strategies. (Source: Otolaryngology - Head and Neck Surgery)

Changes and consistencies in the epidemiology of pediatric adenotonsillar surgery, 1996-2006

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:31 +0100

Conclusion: Although there was an overall increase in the rate of performance of adenotonsillar surgery, population adjusted performance rates of these procedures specifically for infectious indications declined from 1996 to 2006. (Source: Otolaryngology - Head and Neck Surgery)

Induced endolymphatic flow from the endolymphatic sac to the cochlea in Ménière's disease

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:31 +0100

Conclusion: This novel approach might reveal new prospects for treating viral, metabolic, autoimmune, and genetic disorders of the cochlea. (Source: Otolaryngology - Head and Neck Surgery)

Bilateral same-day surgery for bilateral perforated chronic otitis media: Inlay butterfly cartilage myringoplasty

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:31 +0100

Conclusion: Bilateral same-day IBCM offers favorable outcomes in selected patients. (Source: Otolaryngology - Head and Neck Surgery)

Comparison of otologic complications between intensity-modulated and two-dimensional radiotherapies in nasopharyngeal carcinoma patients

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:31 +0100

Conclusion: The incidence of chronic otitis media and abnormal VEMPs in NPC patients treated by IMRT were significantly lower when compared with those treated by 2DRT, demonstrating the superiority of IMRT in decreasing unwanted otologic complications. However, occurrence of OME, which was related with advanced T stage, cannot be reduced by IMRT. (Source: Otolaryngology - Head and Neck Surgery)

Clinical and biomechanical analyses to select a suture material for uvulopalatopharyngeal surgery

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:30 +0100

Conclusion: Poly(glycolide-co-ε-caprolactone) has good handling characteristics and degrades in two stages. It is a suitable suture material for uvulopalatopharyngeal surgery. (Source: Otolaryngology - Head and Neck Surgery)

A prospective study of the clinical impact of a multidisciplinary head and neck tumor board

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:30 +0100

Conclusion: A multidisciplinary tumor board affects diagnostic and treatment decisions in a significant number of patients with newly diagnosed head and neck tumors. The multidisciplinary approach to patient care may be particularly effective in managing malignant tumors, in which treatment plans are most frequently altered. (Source: Otolaryngology - Head and Neck Surgery)

Primary surgery for oropharyngeal cancer

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:30 +0100

Conclusion: Primary surgical treatment of oropharyngeal SCCA is effective in achieving excellent locoregional control and permits deintensification of adjuvant therapy, even in patients with advanced stage disease. Nodal status and race are the primary determinants of disease-free survival. These data provide useful information for counseling and treatment planning. (Source: Otolaryngology - Head and Neck Surgery)

Total parotidectomy defect reconstruction using the buried free flap

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:30 +0100

Conclusion: Free flap reconstruction of total parotidectomy (with or without neck dissection) defects is safe and effective. It does not preclude adjunctive facial reanimation and provides sufficient tissue bulk to match the contralateral facial contour despite radical resections and adjuvant radiation therapy in most cases. (Source: Otolaryngology - Head and Neck Surgery)

Assessment of microvascular anastomosis training in otolaryngology residencies: Survey of United States program directors

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:30 +0100

Conclusion: Many programs find value in providing residents with microvascular training, both in the operating room and in the laboratory. Only a small minority of programs without fellowship positions responded that they perform microvascular surgery on a regular basis (4 or more surgeries per month). (Source: Otolaryngology - Head and Neck Surgery)

The utility of intrathecal fluorescein in cerebrospinal fluid leak repair

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:30 +0100

Conclusion: The use of IF facilitates the accurate localization of CSF leaks and may assist the surgeon in confirming a watertight closure. The lack of intraoperative fluorescein visualization should not rule out the presence of CSF leak, as evidenced by a false-negative rate of 26.2 percent. (Source: Otolaryngology - Head and Neck Surgery)

Quality-of-life outcomes after endoscopic sinus surgery: How long is long enough?

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:30 +0100

Conclusion: At a cohort level, improvements in QOL after ESS do not appear to change between six and 20 months. Clinical trial designs incorporating QOL outcomes after ESS should consider the six-month time frame as an appropriate primary end point. (Source: Otolaryngology - Head and Neck Surgery)

Acute invasive fungal rhinosinusitis: Evaluation of 26 patients treated with endonasal or open surgical procedures

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:29 +0100

Conclusion: AIFRS can be successfully treated with a combination of endonasal surgical debridement and antifungal medications. Endonasal approach is suitable for patients diagnosed in the early stages of the disease and provides a less traumatic option in those patients who already have a poor health status. Open surgery should be preferred in the presence of intraorbital extension, palatinal, and/or intracerebral involvement. Reversing the underlying disease process and immunosuppression is as important as the surgical and antifungal treatment. (Source: Otolaryngology - Head and Neck Surgery)

Fungus and chronic rhinosinusitis: Weighing the evidence

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:29 +0100

Abstract: The hypothesis that fungus causes most, if not all, cases of chronic rhinosinusitis (CRS) has been debated for over a decade. Many opinions and interpretations have been rendered, but it is the objective data that speaks the loudest. The debate simply boils down to a core tenet of the scientific method: Can the data be independently replicated? If so, our patients benefit as new treatments are developed. If not, then the hypothesis must be discarded and new lines of research pursued.Initial clinical trials supporting the fungal hypothesis have not been replicated in recent years by independent investigators. An attempt to independently replicate the basic science foundation of this hypothesis has also failed in a more heterogeneous group of CRS patients. The data can be dissected...

Immunologic response to fungus is not universally associated with chronic rhinosinusitis

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 01:12:29 +0100

Abstract: In the December 2009 issue of this journal, Orlandi et al presented a study in which peripheral blood mononuclear cells (PBMCs) from chronic rhinosinusitis (CRS) patients (5 from Texas, 5 from Utah) and seven nonhealthy controls were stimulated with fungal extracts. Despite the small numbers, they confirmed important aspects of previous studies: 1) CRS patients' PBMCs react to certain fungal stimuli by producing significantly (P < 0.05) higher amounts of interleukin (IL)-5 and IL-13 when compared to controls; 2) CRS patients have an enhanced humoral response (significantly elevated immunoglobulin [Ig] G levels to Alternaria); and 3) CRS patients react independently from an IgE-mediated allergy, as evidenced by that fact that nonallergic CRS patients also produced IL-5 in response...

Bilateral sudden deafness following H1N1 vaccination

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 00:00:00 +0100

Acute loss of function of the cochleovestibular nerve is a multi-factorial disease. The most common causes of this disease are known to be the vascular and viral agents, Ménière's disease, or neoplasm. In cases involving viral agents, the inflammation of the eighth cranial nerve is believed to be a manifestation of a direct viral invasion, local hypersensitivity response, or an antigen-antibody reaction. Acute loss of cochleovestibular function after vaccination was thought to be associated with the latter mechanism. (Source: Otolaryngology - Head and Neck Surgery)

Age-related hearing loss, vitamin B12, and folate in the elderly

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 00:00:00 +0100

Conclusion: Serum folate was significantly lower among elderly with ARHL. Trials on nutritional supplementation may substantiate the role of serum folate in ARHL. (Source: Otolaryngology - Head and Neck Surgery)

Masseteric venous malformations: Diagnosis, treatment, and outcomes

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 00:00:00 +0100

Conclusion: Masseteric venous malformations have a typical clinical presentation and imaging characteristics that should allow clinicians to distinguish them from other abnormalities presenting in this area. Percutaneous sclerotherapy should be considered as a treatment option for these patients and can result in excellent outcomes. (Source: Otolaryngology - Head and Neck Surgery)

Human evolutionary history: Consequences for the pathogenesis of otitis media

Otolaryngology - Head and Neck Surgery — Tue, 26 Oct 2010 00:00:00 +0100

We present here the possible consequences of two human adaptations that may have resulted in ubiquitous otitis media: the interaction of bipedalism and increased brain size, and the loss of facial prognathism resulting from speech or cooking. As a consequence of our adaptation for bipedalism, the female pelvic outlet is constricted, which, in the context of a rapidly enlarging brain, results in humans being born 12 months too soon. Significantly, immature eustachian tube structure and function, in conjunction with an immature immune system, helps to explain the high incidence of otitis media in the first year of life. But the persistence of middle-ear disease beyond this stage is not explained by “immaturity.” The morphology of the palate changed with the adaptations that produced faci...

Gustatory sweating after submandibular gland excision

Otolaryngology - Head and Neck Surgery — Thu, 21 Oct 2010 00:00:00 +0100

A 46-year-old man presented with a two-month history of intermittent painful swelling involving the floor of the mouth and a four-year history of gustatory sweating and flushing in the right submandibular region. The patient's medical history was significant for a right submandibular gland excision for recurrent sialadenitis associated with sialolithiasis five years previously. (Source: Otolaryngology - Head and Neck Surgery)

Therapeutic options in patients with early T stage and advanced N stage of tonsillar squamous cell carcinomas

Otolaryngology - Head and Neck Surgery — Thu, 21 Oct 2010 00:00:00 +0100

Conclusion: OPRT could be still a viable option for managing selected cases of advanced oropharyngeal cancer because one can expect comparable therapeutic outcome as well as quality of life. (Source: Otolaryngology - Head and Neck Surgery)

Esterified hyaluronic acid improves cartilage viability in experimental tracheal reconstruction with an auricular graft

Otolaryngology - Head and Neck Surgery — Thu, 21 Oct 2010 00:00:00 +0100

Conclusion: HYAFF catalyzed wound healing with less fibrous tissue formation, had chondroprotective and stimulatory effects on chondrocyte metabolism, and decreased nitric oxide production and apoptosis via improving the nourishment of free auricular cartilage grafts, subsequently preventing hypoxia and oxidative stress, particularly in the early postimplantation period. (Source: Otolaryngology - Head and Neck Surgery)

Th17 cells and allergic rhinitis: Is there clinical relevance?

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:44 +0100

Further evidence has recently been provided indicating that Th17 cells are involved in allergic inflammation. However, we maintain that some aspects of this topic should be carefully considered. First, some previous studies did not consider clinical data in allergic patients; thus, there was no relationship between phenotypic findings and symptom severity. This issue may be clinically relevant because it has been recently reported that serum IL-17A levels may identify patients with severe allergy both during and outside the birch pollen season. In fact, patients with severe allergy to birch had the highest levels of IL-17°. Moreover, it has been reported that sublingual immunotherapy is capable of decreasing serum IL-17 in allergic subjects. Therefore, serum IL-17 might be a biomarker for...

Response to: No evidence for specific benefit of acupuncture over vitamin B complex in treating persons with olfactory dysfunction, by Jonathan Silas and Richard L. Doty

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:44 +0100

Silas and Doty performed a new statistical evaluation of our material. Regarding their analysis of covariance (ANCOVA)/analysis of variance (ANOVA), Silas and Doty did not describe which patients were selected for analysis, and we assume that the data of all patients were considered. On closer inspection, nine patients treated with vitamin B complex (VBC) and four patients treated by traditional Chinese acupuncture (TCA) had to be excluded from ANCOVA/ANOVA because the score changes in olfactometry varied only within the range of anosmia. This variation is statistically due to random variation. This alters the group size and constitution negatively, and the sample size is thus reduced to nine in the TCA group and six in the VBC group, decreasing the comparability of both treatment groups d...

No evidence for specific benefit of acupuncture over vitamin B complex in treating persons with olfactory dysfunction

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:44 +0100

Vent et al recently reported that traditional Chinese acupuncture (TCA) was superior to treatment with vitamin B complex for improving smell function in persons with post-viral olfactory dysfunction (PVOD). However, a reanalysis of their data does not support this conclusion. We conducted a mixed analysis of covariance (ANCOVA) on their normally distributed data (Kolmogorov-Smirnov, P > 0.10). Treatment group (TCA, vitamin B complex) was entered as a between-subjects variable, and treatment test time (olfactory test scores before and after treatment) was entered as a within-subjects variable. Sex was included as a factor, and age as a covariate. The ANCOVA revealed no significant effects for any variable (all F values < 2.3, all P values > 0.15). (Source: Otolaryngology - Head and Neck Sur...

Primary atrophic rhinitis

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:44 +0100

A 43-year-old woman presented with symptoms of nasal obstruction, crust formation, anosmia, and foul odor. Her symptoms had begun three years earlier. She had no history of nasal surgery, cosmetic surgery, or trauma. Her medical history was noncontributory. On endoscopic examination, severe atrophy of the nasal mucosa, crusts with foul odor, and purulent discharge were observed (). The purulent nasal discharge was cultured and sensitivity tests were performed. The culture grew Klebsiella ozaenae. Considering her history, physical examination, and typical culture results, primary atrophic rhinitis was thought to be the proper diagnosis. Surgical treatment was planned because there are reports that narrowing the nasal cavity can improve the patient's symptoms. Silastic (Dow Corning, Midland,...

Trench mouth

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:44 +0100

A 21-year-old male Marine presented with a three-day history of oral pain. The previous week he had been involved in predeployment field exercises and experienced flu-like symptoms. The patient was a nonsmoker, nondrinker, was on no medications, and had no significant medical or surgical history. Physical examination of the oral cavity showed acute gingivitis and acute inflammation, necrosis, and pseudomembrane formation of mucosal surfaces, including the lips, buccal, palate, and tongue (). The patient was treated with a 10-day course of oral clindamycin, Motrin (McNeil-PPC, Fort Washington, PA) for pain, oral rinses with chlorhexidine (Periogard; Colgate-Palmolive Company, New York, NY), and immediate dental consultation. The patient responded well to treatment and was back to full duty ...

Spontaneous otogenic posterior fossa pneumocephalus

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:43 +0100

We report a patient who presented to us with a six- to eight-week history of gradual decline in neurologic status. The patient had no past medical history that would put her at risk for the development of pneumocephalus; however, computerized tomography (CT) of the head revealed a 5- by 3-cm collection of air in the right posterior fossa with an appreciable dehiscence of bone superior to the vestibular aqueduct. The patient underwent transmastoid retrolabyrinthine approach to the cerebellopontine angle (CPA) to allow for release of this pneumatocele. The patient subsequently demonstrated improvement in neurologic status, and postoperative CT revealed near complete resolution of pneumocephalus. (Source: Otolaryngology - Head and Neck Surgery)

Chondroblastoma of the sphenoid sinus

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:43 +0100

We present a case of a 30-year-old woman with a sphenoid sinus chondroblastoma. We obtained institutional review board approval from our institution in order to present this case. (Source: Otolaryngology - Head and Neck Surgery)

Multicenter study of a novel adjustable tongue-advancement device for obstructive sleep apnea

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:43 +0100

Conclusion: The tissue anchor failure rate of the tested device precludes its clinical use; however, the study results support that a titratable, tongue-suspension device with low direct surgical morbidity in patients with moderate-to-severe sleep apnea significantly improves multiple measures of sleep apnea. Further investigation is warranted. (Source: Otolaryngology - Head and Neck Surgery)

Midterm outcomes of outfracture of the inferior turbinate

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:42 +0100

Conclusion: Compared with the preoperative status, those patients who underwent turbinate outfracture procedures displayed a reduction in the angle and the distance between the inferior turbinate bone and the lateral wall of the nasal fossa and the area lateral to the inferior turbinate bone one month following surgery. Ongoing outcomes of this treatment method have been objectively shown. (Source: Otolaryngology - Head and Neck Surgery)

Preoperative treatment with topical corticoids and bleeding during primary endoscopic sinus surgery

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:42 +0100

Conclusion: The use of topical corticoid (MF) in the preoperative period can improve endoscopic vision, reduce bleeding, and decrease operation time in CRS patients with and without polyps undergoing ESS, but our sample size cannot exclude small, and possibly trivial, group differences. (Source: Otolaryngology - Head and Neck Surgery)

Olfactory and gustatory function in healthy adult Chinese subjects

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:41 +0100

Conclusion: Age and gender affect olfaction in Chinese adults as measured by standard testing methods used in other human populations. In healthy Chinese subjects, gustation was normal and did not vary with age. Our data provide preliminary normative values for future investigation of chemosensation in the Chinese population. (Source: Otolaryngology - Head and Neck Surgery)

Augmentation mentoplasty with osteocartilaginous nasal graft

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:41 +0100

Conclusion: Nasal hump in reduction rhinoplasty is a useful alternative for augmentation mentoplasty on patients with large humps and poor chin projection. It also avoids all the disadvantages of alloplastic materials and eases integration compared with other alternatives in selected cases. (Source: Otolaryngology - Head and Neck Surgery)

Comparison of pharyngeal stenosis between hypopharyngeal patients undergoing primary versus salvage laryngopharyngectomy

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:41 +0100

Conclusion: Primary closure reconstruction is discouraged in patients over the age of 65 years. (Source: Otolaryngology - Head and Neck Surgery)

Regulators and mediators of radiation-induced fibrosis: Gene expression profiles and a rationale for Smad3 inhibition

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:40 +0100

Conclusion: We have characterized the early-phase mRNA expression profiles of the major mediators of radiation-induced fibrosis. Smad3 siRNA effectively abrogated the elevation of Col1A1, TGF-β, TIMP-1, and MMP-2. IL-13 and TNF-α were unaffected by Smad3 silencing and appear to be minor regulators in fibrosis. These findings suggest a therapeutic rationale for Smad3 silencing in vivo. (Source: Otolaryngology - Head and Neck Surgery)

Patulous eustachian tube in bariatric surgery patients

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:40 +0100

Conclusion: Our case series shows a significant prevalence of PET in bariatric surgery patients, which has a correlation with weight loss velocity and magnitude. (Source: Otolaryngology - Head and Neck Surgery)

Tinnitus in the elderly: Profile, correlates, and impact in the Nigerian Study of Ageing

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:40 +0100

Conclusion: Tinnitus is common among elderly Nigerians and is associated with treatable health conditions, such as otitis media, rhinosinusitis, head injury, and hypertension. Its association with functional impairment and reduced quality of life highlights the need for inclusion in any comprehensive health care for the elderly. (Source: Otolaryngology - Head and Neck Surgery)

Errors in the diagnosis and management of necrotizing otitis externa

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:40 +0100

Conclusion: NOE remains a life-threatening condition that requires prolonged antimicrobial therapy. Its incidence may be on the rise. NOE may develop in patients with benign otitis media and externa, and must be considered in all patients with temporal bone inflammation, especially those with risk factors and those who fail to improve with more conservative measures. (Source: Otolaryngology - Head and Neck Surgery)

Antimicrobial resistance of Pseudomonas aeruginosa from otorrhea of chronic suppurative otitis media patients

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:40 +0100

Conclusion: Changes in isolation rate and susceptibility patterns of PA suggest the need for regular surveillance of PA isolates, including antibiotic susceptibility tests, to choose empirical antibiotics and reduce the spread of multidrug-resistant strains. (Source: Otolaryngology - Head and Neck Surgery)

Assessing the immunization status of pediatric cochlear implant recipients using a state-maintained immunization registry

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:40 +0100

Conclusion: A statewide immunization registry can be used to monitor the immunization status of cochlear implant recipients. Subjects were significantly more likely to be incomplete for PPV-23 than for either PCV-7 or HiB vaccinations. (Source: Otolaryngology - Head and Neck Surgery)

A trigger tool fails to identify serious errors and adverse events in pediatric otolaryngology

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:39 +0100

Conclusion: The trigger tool was successful in identifying clerical and administrative errors and adverse events but failed to identify complex errors and adverse events. A hybrid approach for chart review may be cost-effective in pediatric otolaryngology. (Source: Otolaryngology - Head and Neck Surgery)

Extracts from The Cochrane Library: Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA)

Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:39 +0100

Abstract: The “Cochrane Corner” is a quarterly section in the journal that highlights systematic reviews relevant to otolaryngology–head and neck surgery, with invited commentary to aid clinical decision making. This installment features a Cochrane Review titled “Tonsillectomy for periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA),” which suggests beneficial effects of surgery for up to 18 months, but also cautions that the risks of intervention must be balanced against a favorable natural history. (Source: Otolaryngology - Head and Neck Surgery)

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Otolaryngology - Head and Neck Surgery — Sat, 25 Sep 2010 08:28:39 +0100

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Effects of raised-intensity phonation on inflammatory mediator gene expression in normal rabbit vocal fold

Otolaryngology - Head and Neck Surgery — Sun, 22 Aug 2010 23:00:00 +0100

Conclusion: Results provided support for the hypothesis that a transient episode of raised-intensity phonation causes a significant increase in vocal fold inflammatory mRNA expression. Future studies will investigate the signal transduction pathways and mechanisms regulating the vocal fold inflammatory response. The long-term goal of these studies is to advance understanding of the molecular and cellular events underlying phonation-related tissue alterations. (Source: Otolaryngology - Head and Neck Surgery)

The foreshortened malleus: Anatomic variant, not pathologic sign

Otolaryngology - Head and Neck Surgery — Sun, 22 Aug 2010 23:00:00 +0100

Conclusion: Because the data showed no correlation of the physical appearance of the malleus with the mastoid size indicator of otitis media, and right-left symmetry was only hinted, we contend that a foreshortened malleus lacks clinical relevance. Foreshortened malleus is an anatomic variant, not a sign of pathology. (Source: Otolaryngology - Head and Neck Surgery)

Loss of Raf-1 kinase inhibitor protein expression is associated with lymph node metastasis in papillary thyroid cancer

Otolaryngology - Head and Neck Surgery — Sun, 22 Aug 2010 23:00:00 +0100

Conclusion: The loss of Raf-1 kinase inhibitor protein expression is associated with lymph node metastasis of papillary thyroid cancer but not with the progression of primary tumors. (Source: Otolaryngology - Head and Neck Surgery)

Lateral semicircular canal fenestration for congenital conductive hearing loss: Solution for a dilemma

Otolaryngology - Head and Neck Surgery — Sun, 22 Aug 2010 23:00:00 +0100

Conclusion: We demonstrated hearing improvement after lateral semicircular canal fenestration. This technique can be considered as an alternative for patients with middle ear anomalies who are not candidates for ossicular reconstruction. (Source: Otolaryngology - Head and Neck Surgery)

Comparison of safety and efficacy of foam-based versus solution-based ciprofloxacin for acute otitis externa

Otolaryngology - Head and Neck Surgery — Sun, 22 Aug 2010 23:00:00 +0100

Conclusion: Foam-based ciprofloxacin is a safe and an effective new treatment for AOE. (Source: Otolaryngology - Head and Neck Surgery)

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Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:41 +0100

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Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:41 +0100

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Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:40 +0100

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Response to: Pediatric otogenic intracranial abscesses, from Jerzy Kuczkowski et al

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:40 +0100

I would like to thank Drs. Kuczkowski, Mionskowski, and Sierszeń for their comments on the recently published article titled “Pediatric otogenic intracranial abscesses,” and for sharing their experience with intracranial complications of otitis media. We agree that the incidence of complications of otitis media, and in particular intracranial abscess formation, was higher than expected. The high prevalence of intracranial abscesses can probably be attributed to the retrospective nature of our study and that a majority of the abscesses in our series were epidural, associated with sigmoid sinus thrombosis. (Source: Otolaryngology - Head and Neck Surgery)

Pediatric otogenic intracranial abscesses

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:39 +0100

We read with great interest the article “Pediatric otogenic intracranial abscesses” by Isaacson et al. They presented clinical analysis and management of otogenic intracranial abscesses in children. The authors presented 30 pediatric patients with epidural, subdural, intraparenchymal, and petrous apex suppurative complications of otitis media. We would like to make some comments concerning this problem, based on our experience and review of the literature. (Source: Otolaryngology - Head and Neck Surgery)

Ethical conduct of human research: Some controversies

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:39 +0100

We read the article titled “How to review journal manuscripts” by Rosenfeld with great interest. Although the article is very interesting, some details on ethical conduct deserve further discussion. (Source: Otolaryngology - Head and Neck Surgery)

Transnasal endoscopic approach for drainage of pediatric parapharyngeal space abscess

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:39 +0100

A parapharyngeal abscess is one kind of deep neck infection and may cause life-threatening complications. There are two approaches of surgical intervention: 1) the external or open neck approach and 2) the transoral approach. It is generally accepted that parapharyngeal abscesses require an external approach to gain control over the great vessels of the neck. Herein, we present a pediatric case with a parapharyngeal abscess near the skull base, which was drained via transnasal endoscopic approach. Institutional Review Board approval was obtained. (Source: Otolaryngology - Head and Neck Surgery)

Gingival leukemic infiltration as the first manifestation of acute myeloid leukemia

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:39 +0100

The acute leukemias are a group of neoplastic diseases that are characterized by proliferation of immature white cells in the bone marrow and/or blood. They are often associated with leukopenia, anemia, and thrombocytopenia. Oral manifestations such as bleeding, gingival enlargement, ulceration, and infection in patients with leukemia have been described in these patients. (Source: Otolaryngology - Head and Neck Surgery)

Cochlear implantations in patients with cochlear fistulae

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:38 +0100

This study was approved by the Institutional Review Board of Asan Medical Center. (Source: Otolaryngology - Head and Neck Surgery)

Nasal natural killer/T-cell lymphoma

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:38 +0100

A 56-year-old man presented with a two-year history of blood-tinged, purulent nasal discharge on the right side. Nasal lesions were displayed by endoscopy (). The microscopic findings of biopsy specimens showed tumor cells were mixed with inflammatory cells with areas of geographic necrosis, angiocentricity, and angioinvasion. The staining of neoplastic cells was positive for cytoplasmic CD3, CD56 (), T-cell−restricted intracellular antigen, Epstein-Barr virus (EBV)−encoded early RNA-1 in situ hybridization, but was negative for CD20. These immunohistochemical studies confirmed the diagnosis of nasal natural killer/T-cell lymphoma (NNKTL). (Source: Otolaryngology - Head and Neck Surgery)

Adenoma of the ceruminous gland

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:38 +0100

A five-year-old boy was referred to our department with intermittent serous otorrhea due to a recurrent mass in his right external auditory canal (EAC). When the patient was four years of age, this lesion had been removed at another hospital. Histologically, the lesion was consistent with a ceruminoma. No other symptoms or signs were reported. A 0.6-cm pink-reddish, condyloma-like mass that bled easily was localized in the superior wall of the EAC at the level of the bone-cartilage junction (). The tympanic membrane was normal. Computed tomography revealed no deep extension of the lesion. The lesion was removed completely via a transmeatal approach, and no histological involvement of the cartilaginous or bony EAC was detected. Histopathology revealed a well-differentiated, localized neopla...

Endoscopic sphenoid nasalization for the treatment of advanced sphenoid disease

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:38 +0100

In most cases of sphenoid sinusitis, enlargement of the obstructed sinus ostium is sufficient to provide drainage of retained secretions and reestablish mucociliary clearance. In the setting of failed prior sphenoidotomy or advanced disease, however, conventional sphenoidotomy may prove inadequate to address the pathologic condition at hand. In such instances, sphenoid nasalization may be utilized to widely open the sphenoid sinus, providing enhanced intraoperative exposure, postoperative drainage, and long-term surveillance. (Source: Otolaryngology - Head and Neck Surgery)

Reducing risk of fire in the operating room using coblation technology

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:38 +0100

Abstract: Operating room fires are rare, but when they occur, they have potentially devastating and deadly consequences. Coblation (ArthroCare ENT, Austin, TX) technology has become popular for many otolaryngology procedures and seems to have the advantage of reducing fire risk. Our objective was to test the Coblator II on various flammable materials commonly found and used in the operating room. We placed the active Coblator II at the highest settings, in direct contact with flammable operating room equipment and materials, and made the environment even more volatile by introducing oxygen into the testing environment. We found that the Coblator II did not produce fire when in contact with any of the materials. This finding is very important in otolaryngology because airway procedures ofte...

Coblation lesion formation in a porcine tongue model

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:37 +0100

Conclusion: The porcine tongue model describes the relationship between lesion size and cold ablation device settings. Setting, but not time, significantly affects lesion size. The coblation setting and treatment time directly impact the amount of energy delivered. Additionally, submucosal normal saline injection significantly increases lesion size at all settings and application times. Given the average lesion diameter described in this study, placing lesions 1 cm apart will optimize the area affected by coblation while minimizing lesion overlap. (Source: Otolaryngology - Head and Neck Surgery)

Obstructive sleep apnea surgery practice patterns in the United States: 2000 to 2006

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:34 +0100

Conclusion: Surgical treatment is performed in 0.2 percent of all adults with OSA annually. Validation of the exploratory findings concerning procedure type and cost requires additional studies, ideally including adjustment for clinical factors. (Source: Otolaryngology - Head and Neck Surgery)

Acellular porcine intestinal submucosa as fascial graft in an animal model: Applications for revision tympanoplasty

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:34 +0100

Conclusion: Fascia regeneration may be possible with use of an acellular porcine intestinal submucosa graft in an animal model. Future studies may prove beneficial in restoring fascia in humans. Implications for potential advantages in tympanoplasty are discussed. (Source: Otolaryngology - Head and Neck Surgery)

A combination antioxidant therapy prevents age-related hearing loss in C57BL/6 mice

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:33 +0100

Conclusion: Combination antioxidant therapy effectively decreased threshold shifts on ABR within an animal model of ARHL. Combination antioxidant therapy, with further research and investigation, may provide a safe and cost-effective method of preventing presbycusis in the growing elderly population. (Source: Otolaryngology - Head and Neck Surgery)

Long-term results with the Rion E-type semi-implantable hearing aid

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:33 +0100

Conclusion: For long-term success in implantation of the IHA, careful control of middle ear inflammation and measures against eustachian tube dysfunction are required in addition to technological advancements. (Source: Otolaryngology - Head and Neck Surgery)

Aging effect on galvanic vestibular-evoked myogenic potentials

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:33 +0100

Conclusion: The decline of the amplitude and prolongation of the latencies in GVS-VEMPs after the age of 60 may, at least in part, be caused by the decrease in the number of vestibular afferents and their caliber. (Source: Otolaryngology - Head and Neck Surgery)

Benign paroxysmal positional vertigo secondary to inner ear disease

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:33 +0100

Conclusion: The mean duration of treatment for BPPV with ISSHL or unilateral vestibulopathy was longer than for other groups. The different pathophysiologies of s-BPPV associated with different inner ear diseases may explain its diverse clinical features and courses. (Source: Otolaryngology - Head and Neck Surgery)

Canalith repositioning variations for benign paroxysmal positional vertigo

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:33 +0100

Conclusion: However the head is moved, as long as it is moved rapidly enough and through the correct planes in space, repositioning treatments are likely to be effective. Therefore, clinicians have a range of choices in selecting the treatment best suited for each patient's unique needs. (Source: Otolaryngology - Head and Neck Surgery)

Hesperidin stimulates cystic fibrosis transmembrane conductance regulator–mediated chloride secretion and ciliary beat frequency in sinonasal epithelium

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:32 +0100

Conclusion: Our in vitro and in vivo investigations provide strong support for future testing of this robust Cl– secretagogue and CBF activator in human clinical trials for CRS. (Source: Otolaryngology - Head and Neck Surgery)

Sinogenic orbital and subperiosteal abscesses: Microbiology and methicillin-resistant Staphylococcus aureus incidence

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:32 +0100

Conclusion: Abscess cultures grew a mixture of bacteria, including gram-positive cocci, gram-negative bacilli, and anaerobes. Although streptococci were the most common genus of bacteria isolated, S. aureus was the single most common pathogen recovered and one fourth of these cases were methicillin-resistant S. aureus. Given the significant morbidity that may result from inadequate treatment, an antibiotic active against methicillin-resistant S. aureus should be included in the initial broad-spectrum antimicrobial treatment regimen of orbital and subperiosteal abscesses of sinusitis origin until culture results are available. (Source: Otolaryngology - Head and Neck Surgery)

Released intranasal eosinophilic major basic protein as a diagnostic marker for polypoid chronic rhinosinusitis

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:32 +0100

Conclusion: Toxic eosinophil major basic protein levels are elevated in polypoid chronic rhinosinusitis patients compared to control groups that have similar clinical presentations but upon closer examination turn out not to have chronic rhinosinusitis. In the future, the detection of eosinophil major basic protein in nasal mucus may become a sensitive and specific marker for chronic rhinosinusitis and a helpful diagnostic tool. (Source: Otolaryngology - Head and Neck Surgery)

Immunoglobulin E–mediated food allergies among adults with allergic rhinitis

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:31 +0100

Conclusion: Peanut and shrimp were the most common foods encountered in adults with allergic rhinitis. Peanut was best in predicting other food allergies. Total IgE levels with inhalants plus peanut provided the optimal combination of SE, SP, PPV, and NPV. In vitro testing may be important to identify and prevent anaphylaxis to foods in adults. (Source: Otolaryngology - Head and Neck Surgery)

Esophageal pathology in patients after treatment for head and neck cancer

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:31 +0100

Conclusion: Esophageal pathology is extremely common in patients treated for HNCA. These findings support routine esophageal screening after HNCA treatment. (Source: Otolaryngology - Head and Neck Surgery)

Utilizing computed tomography as a road map for designing selective and superselective neck dissection after chemoradiotherapy

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:31 +0100

Conclusion: Negative computed tomography accurately predicts pathologic complete response at neck dissection. Neck dissection can be avoided in these patients. Additionally, computed tomography reliably identifies low risk neck levels that do not require dissection, permitting selective neck dissection or superselective neck dissection in partial response patients with limited residual disease. (Source: Otolaryngology - Head and Neck Surgery)

Development and preliminary validation of the Lip Reanimation Outcomes Questionnaire

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:31 +0100

Conclusion: The lip reanimation outcome questionnaire has promising reliability and validity in this preliminary study, but additional psychometric testing with larger samples is required before the survey can be recommended for clinical use. (Source: Otolaryngology - Head and Neck Surgery)

Demographics and efficacy of head and neck cancer screening

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:30 +0100

Conclusion: A minority of patients presenting to a head and neck cancer screening clinic will have a suspicious lesion identified. Given these findings, to achieve maximal potential benefit, future head and neck cancer screening clinics should target patients with identifiable risk factors and take full advantage of opportunities for education and prevention. (Source: Otolaryngology - Head and Neck Surgery)

Radiofrequency inferior turbinate reduction: An evaluation of olfactory and respiratory function

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:30 +0100

Conclusion: RITR may provide excellent outcomes in terms of improvement in olfactory function and nasal flow in patients affected by turbinate hypertrophy refractory to medical therapy. (Source: Otolaryngology - Head and Neck Surgery)

Clinical value of office-based endoscopic incisional biopsy in diagnosis of nasal cavity masses

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:30 +0100

Conclusion: Endoscopic incisional biopsy alone did not ensure accurate diagnosis of nasal cavity tumors, but in combination with preoperative imaging it was helpful for the diagnosis of nasal cavity malignancies. (Source: Otolaryngology - Head and Neck Surgery)

Primary care perceptions of otolaryngology

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:30 +0100

Conclusion: This study demonstrates that many primary care residents are not aware of the scope of expertise that an otolaryngologist may offer. Increased exposure to otolaryngology during primary care residency training may increase understanding of the specialty among primary care physicians. (Source: Otolaryngology - Head and Neck Surgery)

A practical guide to understanding Kaplan-Meier curves

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:30 +0100

Abstract: In 1958, Edward L. Kaplan and Paul Meier collaborated to publish a seminal paper on how to deal with incomplete observations. Subsequently, the Kaplan-Meier curves and estimates of survival data have become a familiar way of dealing with differing survival times (times-to-event), especially when not all the subjects continue in the study. “Survival” times need not relate to actual survival with death being the event; the “event” may be any event of interest. Kaplan-Meier analyses are also used in nonmedical disciplines.The purpose of this article is to explain how Kaplan-Meier curves are generated and analyzed. Throughout this article, we will discuss Kaplan-Meier estimates in the context of “survival” before the event of interest. Two small groups of hypothetical dat...

Improving the letter of recommendation

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:29 +0100

Abstract: The selection of applicants to otolaryngology training programs is a challenging task. Applicants and their evaluators rely on objective and subjective data to facilitate the selection process. Unfortunately, data are often less helpful than either side assumes, suffering from poor validity and reliability in predicting future performance. The traditional resume-based letter of recommendation bears some responsibility in this. It is often a lengthy reiteration of already available objective data and contains nonstandardized, superlative evaluations of personal attributes. As a result, many letters are similar, describing “excellent” candidates who have done well on previous examinations and clerkships. Research has indicated improved reliability and satisfaction as well as de...

A physician's personal experience as a cancer of the neck patient

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:29 +0100

Abstract: The author presents his personal experiences as a physician who had several surgical procedures to remove pyriform sinus squamous cell carcinoma, which included laryngectomy. He recently published a book that captures the three years of his life that followed his throat cancer diagnosis and tells his story of facing and dealing with medical and surgical treatments and adjusting to life afterwards. The editorial highlights some of the book's features that relate to the important role of head and neck surgeons in the care of patients with cancer. (Source: Otolaryngology - Head and Neck Surgery)

Art

Otolaryngology - Head and Neck Surgery — Wed, 18 Aug 2010 06:08:29 +0100

The art of medicine is often pondered yet rarely discussed. Even this journal may be guilty of neglect, as suggested in the astute letter that follows. My response is offered as a tribute to this timeless art and its many facets. (Source: Otolaryngology - Head and Neck Surgery)

Huge radicular cyst

Otolaryngology - Head and Neck Surgery — Mon, 16 Aug 2010 23:00:00 +0100

A 29-year-old man presented with symptoms of left nasal obstruction, cheek pain, and swelling. Endoscopic examination revealed swelling of both nasal floors, especially on the left side. Computed tomography demonstrated a huge cystic lesion eroding the hard palate, upper alveolus, and both maxillae (). The roots of multiple teeth were observed along the lower margin of the cyst. Under a tentative diagnosis of radicular cyst or odontogenic keratocyst, we considered surgical treatment. Because of the cyst's large size and involvement with the teeth roots, we planned endoscopic intranasal marsupialization. (Source: Otolaryngology - Head and Neck Surgery)

An unusual presentation of posterior glottic stenosis

Otolaryngology - Head and Neck Surgery — Mon, 16 Aug 2010 23:00:00 +0100

This article received MedStar institutional review board approval. (Source: Otolaryngology - Head and Neck Surgery)

Myiasis of facial wounds by Cochliomyia hominivorax sustained in a natural disaster in Haiti

Otolaryngology - Head and Neck Surgery — Mon, 16 Aug 2010 23:00:00 +0100

On January 12, 2010, the nation of Haiti was rocked by a 7.2 magnitude earthquake that devastated the already struggling nation. In the relief effort that followed, we encountered two patients with open facial lacerations that were infested with Cochliomyia hominivorax or New World screwworms. The Institutional Review Board aboard the USNS Comfort approved this report. (Source: Otolaryngology - Head and Neck Surgery)

Clinical, histopathologic, and radiographic indicators of malignancy in head and neck paragangliomas

Otolaryngology - Head and Neck Surgery — Mon, 16 Aug 2010 23:00:00 +0100

Conclusion: This study suggests that pain, a rapidly enlarging neck mass, and younger age are predictive factors of underlying malignancy, which should prompt one to consider an aggressive diagnostic and management approach. (Source: Otolaryngology - Head and Neck Surgery)

Surgical missions to developing countries: Ethical conflicts

Otolaryngology - Head and Neck Surgery — Mon, 16 Aug 2010 23:00:00 +0100

Abstract: Each year scores of American physicians and nurses travel overseas, usually at their own expense, aiming to improve the lot of desperate patients in developing countries. Our journals are filled with images of smiling children who have benefited from these gifts of care. Still, practicing medicine, and especially surgery, in a sporadic fashion in distant lands can lead to poor outcomes. It does little to improve public health or advance medical education. We address some of the ethical dilemmas intrinsic to international surgical missions and discuss how we might redirect our resources to provide better care to more people. (Source: Otolaryngology - Head and Neck Surgery)

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Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:08 +0100

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Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:08 +0100

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Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:08 +0100

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Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:08 +0100

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Response to: Effects of traditional Chinese acupuncture in post-viral olfactory dysfunction, from Earl V. Wilkinson

Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:08 +0100

Thank you, Dr. Wilkinson, for your helpful comment. Indeed, we used the nomenclature applied by our Chinese colleague, and we may thus correct the points used to the internationally valid nomenclature: (Source: Otolaryngology - Head and Neck Surgery)

Effects of traditional Chinese acupuncture in post-viral olfactory dysfunction

Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:08 +0100

I was pleased to see the original research article “Effects of traditional Chinese acupuncture in post-viral olfactory dysfunction” in the April issue of the journal. I applaud Dr. Vent for her efforts to find solutions for this frustrating problem. Six points were documented, but 10 insertion points were used. Point descriptions Di20, Ma36, and Ni3 are not clear and cannot be used to duplicate or verify this study. (Source: Otolaryngology - Head and Neck Surgery)

A pharyngeal foreign body presenting as a painful neck mass

Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:08 +0100

One of the most common consultations requested by the accident and emergency department of an otorhinolaryngologist is for a foreign body ingestion. Fish bones are the most common foreign body ingested by adults, and most of them are found lodged in the oropharynx. Many of them can be identified and retrieved as an outpatient consultation. In symptomatic cases where the initial clinical findings are negative, other modalities of investigation, such as an esophagogastroduodenoscopy and imaging, should be considered. Patients with a history of foreign body ingestion should be carefully attended to prevent the development of serious complications. To highlight the potential dangers of this condition, we present a case of retained fish bone that presented as a painful subcutaneous neck mass. (...

Sigmoid sinus thrombosis associated with a parapharyngeal deep lobe parotid gland tumor causing seizure

Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:08 +0100

We present an unusual case of a deep lobed parotid gland tumor that occupied the parapharyngeal and pterygomaxillary space with extension to the skull base, causing occlusion of the jugular vein with subsequent thrombosis of the sigmoid and transverse sinuses. The resultant intracranial venous hypertension caused symptoms of tonic-clonic seizures that, to the best of our knowledge, have not been previously reported. (Source: Otolaryngology - Head and Neck Surgery)

Tularemia presenting as a cervical abscess

Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:07 +0100

A 40-year-old man presented with two months of progressive left neck swelling, night sweats, and fatigue. He worked as a hunting guide in New Mexico and reported multiple bites from insects, including deer flies, on the job. He had been treated with penicillin, cephalexin, and clindamycin, but his symptoms persisted. On presentation to our institution, his examination was notable for a temperature of 97.4°F, clear throat, and a 4 × 5-cm erythematous, mildly tender mass in the left neck with an area of fluctuance superiorly (). Fine needle aspiration revealed necrotizing acute inflammation without granulomas; cultures were negative, and smears were negative for acid-fast bacilli. Chest x-ray was clear, and a tuberculin skin test was negative. A contrast-enhanced computed tomography (CT) s...

Lateral pharyngeal diverticulum

Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:07 +0100

A 43-year-old man presented with halitosis and the sensation of a foreign body in the right throat for 10 years. He complained that the symptoms worsened after meals and disappeared occasionally on rubbing his right neck with his fingers. He had no history of trauma or surgery on the neck. On flexible laryngeal fiberscopic examination, a pharyngeal pouch filled with food material was observed in the right anterolateral pharyngeal wall above the pyriform sinus (). Barium esophagography demonstrated a lateral pharyngeal diverticulum with pooling of contrast material (). The pharyngeal diverticulum was approximately 2 cm wide, with a narrow isthmus. The patient underwent endoscopic diverticulotomy, which removed the inferior wall of the diverticular opening. The patient's symptoms disappeared...

Early results with semisynthetic total ossicular replacement prosthesis

Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:07 +0100

The objective of this article is to describe a new semisynthetic total ossicular prosthesis (ssTORP). The ssTORP is obtained by assembling a synthetic shaft with an autolog cartilage head. To make the shaft, we used an adjustable-length stapedotomy prosthesis made of platinum and polytetrafluoroethylene (PTFE) (7 mm in total length and 0.4 mm in diameter). The base of the hook is cut. In this way, a shaft made of platinum and PTFE, 4 mm in length and 0.4 mm in diameter, is obtained. It represents an artificial stapes superstructure. The shaft is supplied with a blunt platinum tip 1 mm in length and 0.2 mm in diameter. The blunt tip is completely inserted into the cartilage head of the prosthesis. The PTFE base of the shaft is positioned on the footplate. The head of the prosthesis can be m...

Application of diffusion tensor imaging after glossectomy

Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:07 +0100

Difficulty in visualizing the intricate architecture of the tongue has limited our understanding of its function during speech, mastication, and swallowing, as well as its adaptation to surgical procedures. Tractography visualization using diffusion tensor imaging (DTI), a semiautomatic technique, can detect and display the spatial distribution of the muscle fiber bundle orientations as three-dimensional (3D) trajectories in human and calf tongues. DTI is a magnetic resonance imaging (MRI) technique that measures the diffusivity of water in different directions and estimates fiber bundle orientation at each voxel, mathematically measuring the spatial distribution of diffusion tensors. It has been successfully applied to the study of neurologic conditions, including stroke, multiple scleros...

Proinflammatory mediators in nasal lavage of subjects with occupational rhinitis

Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:05 +0100

Abstract: We sought to investigate the type and kinetics of late-phase nasal inflammatory response after nasal challenge with occupational allergens. Participants were 10 subjects experiencing work-related rhinitis symptoms who underwent specific inhalation challenge and tested positive for occupational rhinitis. During challenge, we monitored changes in inflammatory cells, eosinophil cationic protein, myeloperoxidase, and interleukin-8 in nasal lavage samples. The challenge with the active agent induced a significant increase in the percentage of eosinophils at 30 minutes as compared with prechallenge values (P = 0.04). A significant increase in eosinophil cationic protein levels after challenge with the control (P = 0.01) and active agent (P = 0.02) was observed in the late phase after c...

Imaging of granulomatous and chronic invasive fungal sinusitis: Comparison with allergic fungal sinusitis

Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:05 +0100

Conclusion: Radiological features of IFS are described that are different from AFS. (Source: Otolaryngology - Head and Neck Surgery)

Evaluation of optical rhinometry for nasal provocation testing in allergic and nonallergic subjects

Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:04 +0100

Conclusion: This initial study demonstrates a correlation between subjective symptoms of nasal patency and objective measurements with the optical rhinometer. Less histamine amount necessary to incite nasal congestion in allergic rhinitis suggests that these patients may be primed to the effects of histamine. These preliminary data suggest that optical rhinometry is able to assess changes in nasal patency during challenges with histamine and oxymetazoline. (Source: Otolaryngology - Head and Neck Surgery)

Waiting for the evidence: VEMP testing and the ability to differentiate utricular versus saccular function

Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:04 +0100

Abstract: The advent of cervical vestibular evoked myogenic potentials (CVEMPs) marked a milestone in clinical vestibular testing because they provided a simple means of assessing human otolith function. The availability of air-conducted (AC) sound and bone-conducted vibration (BCV) to evoke CVEMPs and development of a new technique of recording ocular vestibular-evoked myogenic potentials (OVEMPs) have increased the complexity of this simple test, yet extended its diagnostic capabilities. Here we highlight the evidence-based assumptions that guide interpretation of AC sound– and BCV-evoked VEMPs and the gaps in VEMP research thus far. (Source: Otolaryngology - Head and Neck Surgery)

Ocular vestibular-evoked myogenic potentials to bone-conducted vibration in superior vestibular neuritis show utricular function

Otolaryngology - Head and Neck Surgery — Wed, 21 Jul 2010 05:43:04 +0100

Conclusion: The n10 component of the oVEMP to BCV is probably mediated by the superior vestibular nerve and so mainly by the utricular receptors. The n10 AR is almost as good as canal paresis in identifying the affected side in patients. (Source: Otolaryngology - Head and Neck Surgery)

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Response to: Huge radicular cyst of the maxilla: Some clinicopathological considerations, from Pitak-Arnnop et al

Huge radicular cyst of the maxilla: Some clinicopathological considerations

Mondini dysplasia with paradoxical cerebrospinal fluid rhinorrhea

Osteonecrosis of the maxilla associated with the use of bisphosphonates

Surgical closure of persistent tracheoesophageal fistulas by esophageal suturing and cranial transposition of the trachea

Relationship between olfactory function and olfactory neuronal population in C57BL6 mice injected intraperitoneally with 3-methylindole

Effect of pharyngeal packing during nasal surgery on postoperative nausea and vomiting

Prognostic assessments of medical therapy and vestibular testing in post-traumatic migraine-associated dizziness patients

Publication misrepresentation among otolaryngology residency applicants

Spanish validation of the University of Washington Quality of Life questionnaire for head and neck cancer patients

Correlation of biomarkers in head and neck squamous cell carcinoma

Minimally invasive video-assisted thyroidectomy versus conventional thyroidectomy: A cost-effective analysis

Fracture patterns of the nasal septum

Correlation of pepsin-measured laryngopharyngeal reflux disease with symptoms and signs

How does reflux affect laryngeal tissue quality? An experimental and histopathologic animal study

Systematic review of laryngeal reinnervation techniques

Otolaryngology and Irish literature: An important medico-literary alliance

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Editorial Board

Contents

Correction

Response to: Scientific independence of authors and of journals to their published articles, from Patrick Froehlich

Scientific independence of authors and of journals to their published articles

Response to: The human external nose and its evolutionary role in the prevention of obstructive sleep apnea, from Mladina et al

The human external nose and its evolutionary role in the prevention of obstructive sleep apnea

Osteochondroma of the mandibular condyle manifesting only as conductive hearing loss

Congenital cholesteatoma originating within the facial nerve canal

Oropharyngeal hairy polyps: An uncommon cause of infantile dyspnea and dysphagia

Endoscopic vein graft harvest in head and neck reconstruction

Seeing the light: Endoscopic endonasal intraconal orbital tumor surgery

Biofilm and persistent inflammation in endoscopic sinus surgery

Influence of race and ethnicity on access to care among children with frequent ear infections

The quality of life and health utility burden of recurrent respiratory papillomatosis in children

Changes and consistencies in the epidemiology of pediatric adenotonsillar surgery, 1996-2006

Induced endolymphatic flow from the endolymphatic sac to the cochlea in Ménière's disease

Bilateral same-day surgery for bilateral perforated chronic otitis media: Inlay butterfly cartilage myringoplasty

Comparison of otologic complications between intensity-modulated and two-dimensional radiotherapies in nasopharyngeal carcinoma patients

Clinical and biomechanical analyses to select a suture material for uvulopalatopharyngeal surgery

A prospective study of the clinical impact of a multidisciplinary head and neck tumor board

Primary surgery for oropharyngeal cancer

Total parotidectomy defect reconstruction using the buried free flap

Assessment of microvascular anastomosis training in otolaryngology residencies: Survey of United States program directors

The utility of intrathecal fluorescein in cerebrospinal fluid leak repair

Quality-of-life outcomes after endoscopic sinus surgery: How long is long enough?

Acute invasive fungal rhinosinusitis: Evaluation of 26 patients treated with endonasal or open surgical procedures

Fungus and chronic rhinosinusitis: Weighing the evidence

Immunologic response to fungus is not universally associated with chronic rhinosinusitis

Bilateral sudden deafness following H1N1 vaccination

Age-related hearing loss, vitamin B12, and folate in the elderly

Masseteric venous malformations: Diagnosis, treatment, and outcomes

Human evolutionary history: Consequences for the pathogenesis of otitis media

Gustatory sweating after submandibular gland excision

Therapeutic options in patients with early T stage and advanced N stage of tonsillar squamous cell carcinomas

Esterified hyaluronic acid improves cartilage viability in experimental tracheal reconstruction with an auricular graft

Th17 cells and allergic rhinitis: Is there clinical relevance?

Response to: No evidence for specific benefit of acupuncture over vitamin B complex in treating persons with olfactory dysfunction, by Jonathan Silas and Richard L. Doty

No evidence for specific benefit of acupuncture over vitamin B complex in treating persons with olfactory dysfunction

Primary atrophic rhinitis

Trench mouth

Spontaneous otogenic posterior fossa pneumocephalus

Chondroblastoma of the sphenoid sinus

Multicenter study of a novel adjustable tongue-advancement device for obstructive sleep apnea

Midterm outcomes of outfracture of the inferior turbinate

Preoperative treatment with topical corticoids and bleeding during primary endoscopic sinus surgery

Olfactory and gustatory function in healthy adult Chinese subjects

Augmentation mentoplasty with osteocartilaginous nasal graft

Comparison of pharyngeal stenosis between hypopharyngeal patients undergoing primary versus salvage laryngopharyngectomy

Regulators and mediators of radiation-induced fibrosis: Gene expression profiles and a rationale for Smad3 inhibition

Patulous eustachian tube in bariatric surgery patients

Tinnitus in the elderly: Profile, correlates, and impact in the Nigerian Study of Ageing

Errors in the diagnosis and management of necrotizing otitis externa

Antimicrobial resistance of Pseudomonas aeruginosa from otorrhea of chronic suppurative otitis media patients

Assessing the immunization status of pediatric cochlear implant recipients using a state-maintained immunization registry