MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Pathology International' source. Thu, 09 Feb 2012 00:42:19 +0100 http://www.medworm.com/index.php?rid=5669160&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02772.x In this study, we evaluated the expression statuses and the clinical significance of MDR1 (ABCB1), MDR‐associated proteins (MRPs/ABCC) 1, 2 and 3, and breast cancer resistance protein (BCRP/ABCG2) in 67 surgically resected PDACs by immunohistochemistry. MDR1, MRP1, MRP2, MRP3 and BCRP were expressed in 35 (52.2%), 56 (83.6%), 61 (91.0%), 49 (73.1%) and 49 (73.1%) out of 67 cases, respectively. The expression statuses of the MDR‐related proteins were positively correlated with each other (P < 0.05). Tumors expressing MRP1 (P= 0.015), MRP2 (P= 0.022) and MRP3 (P < 0.001) demonstrated more frequent perineural invasion. MDR1 expression was significantly correlated with lymphatic invasion (P= 0.047). High BCRP expression in PDAC was a significant prognostic factor for early tumor recu... Pathology International journals http://www.medworm.com/rss/comments.php?id=5669160 Wed, 01 Feb 2012 05:00:00 +0100 5669160 http://www.medworm.com/index.php?rid=5651002&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02776.x In conclusion, our data suggest that global histone H3 and H4 modification patterns are potential markers of tumor recurrence and disease‐free survival in NSCLC patients. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5651002 Wed, 01 Feb 2012 05:00:00 +0100 5651002 http://www.medworm.com/index.php?rid=5651005&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02773.x In conclusion, a malignant diagnosis of EnFVPTC should not be used to cover this spectrum of tumors until uncertainty about the nature of this lesion is settled, whether it is benign, precancerous or malignant. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5651005 Mon, 30 Jan 2012 05:00:00 +0100 5651005 http://www.medworm.com/index.php?rid=5651004&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02778.x An evaluation of epidermal growth factor receptor (EGFR) phenotypic expression in malignant pleural and peritoneal mesothelioma was undertaken, using immunohistochemical (IHC) and fluorescence in situ hybridization (FISH) analysis. Thirty‐eight malignant mesothelioma (MM) specimens were subjected to IHC staining and FISH to evaluate the expression of EGFR protein and gene status. Overall positive IHC reaction was detected in 20/38 (53%) cases, in 11/22 (50%) pleural MM, and in 9/16 (56%) peritoneal MM. Our study confirmed that EGFR membranous expression is a common feature in MM, but not in benign mesothelial lesion. Thirty‐seven cases did not show a gene copy number gain. Only one case showed a copy number gain. The protein overexpression of EGFR was not related to a gene copy number ... Pathology International journals http://www.medworm.com/rss/comments.php?id=5651004 Mon, 30 Jan 2012 05:00:00 +0100 5651004 http://www.medworm.com/index.php?rid=5651003&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02784.x This study is the first to address the clinical significance of PAX5+ primary cutaneous CD30+ T‐cell LPDs. These cases were distinct regarding PAX5 expression and a relatively aggressive clinical course versus conventional primary cutaneous CD30+ T‐cell LPDs. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5651003 Mon, 30 Jan 2012 05:00:00 +0100 5651003 http://www.medworm.com/index.php?rid=5611916&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02785.x In this study, we examined the expressions of β‐tubulin isotypes in classical Hodgkin's lymphoma (cHL) by immunohistochemistry. Among the β‐tubulin isotypes, class II β‐tubulin (31/34, 91%) was most frequently overexpressed in the cytoplasm of almost all Hodgkin's and Reed‐Sternberg (HRS) cells, followed by class I β‐tubulin (18/34, 53%) and class III β‐tubulin (12/34, 35%). Class IV β‐tubulin was not expressed in any cHL case. Class I β‐tubulin was expressed in the background lymphoid cells as well as the HRS cells. Thus, our results indicate that class II β‐tubulin may be very useful for immunohistochemical diagnosis of cHL, and provide valuable information for the potential application of β‐tubulin isotype‐specific targeting. (Source: Pathology Internation... Pathology International journals http://www.medworm.com/rss/comments.php?id=5611916 Sat, 21 Jan 2012 04:45:52 +0100 5611916 http://www.medworm.com/index.php?rid=5599858&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02767.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5599858 Wed, 18 Jan 2012 05:46:17 +0100 5599858 http://www.medworm.com/index.php?rid=5599857&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02754.x This study aimed to assess the differences in cellular composition of the inflammatory reactive background of HIV‐HLs. We examined infiltrating T lymphocytes, specifically regulatory T cells, cytotoxic cells, Epstein‐Barr virus (EBV) related antigens and HIV‐receptor CCR5. In all HIV‐HL cases, Hodgkin and Reed‐Sternberg (HRS) cells showed EBER1 expression, LMP‐1 staining positivity and EBNA‐2 staining negativity, except for one case which showed LMP‐1 staining negativity. Our histological findings indicate the percentage of CD8+, TIA‐1+ lymphocytes was significantly higher in HIV‐HL than in non‐HIV‐HL cases (P < 0.05). On the other hand, the percentage of CD4+, FOXP3+ lymphocytes was significantly lower in HIV‐HL than in non‐HIV‐HL cases (P < 0.0... Pathology International journals http://www.medworm.com/rss/comments.php?id=5599857 Wed, 18 Jan 2012 05:46:00 +0100 5599857 http://www.medworm.com/index.php?rid=5585641&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02775.x In conclusion, DEK overexpression appears to be associated with breast cancer progression and DEK may potentially be used as a breast cancer biomarker for the early diagnosis, prognostic evaluation and therapeutic target for breast cancer. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5585641 Fri, 13 Jan 2012 05:00:00 +0100 5585641 http://www.medworm.com/index.php?rid=5585640&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02777.x We report a case of glomerular cystic kidney disease (GCKD) associated with tuberous sclerosis complex (TSC) in a neonate. The patient displayed progressive abdominal enlargement attributed to GCKD associated with TSC. After birth, the right kidney was resected because it compressed his liver and right lung, and possible malignancy could not be excluded. Macroscopically, the resected kidney was markedly enlarged, and histologically the kidney had numerous glomerular cysts accompanied by papillary epithelial growth. Notably, a small area of normal parenchyma was observed at the lower pole. The epithelial cells of the cysts displaying a papillary growth pattern were positive for mTOR, phosphorylated mTOR, and phosphorylated S6 ribosomal protein (p‐S6). The morphologically noncystic, normal... Pathology International journals http://www.medworm.com/rss/comments.php?id=5585640 Fri, 13 Jan 2012 05:00:00 +0100 5585640 http://www.medworm.com/index.php?rid=5585639&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02782.x Reported here is a case of Müllerian adenosarcoma of the ovary which contained a primitive neuroectodermal tissue component within the stroma. The adenosarcoma coexisted with clear cell adenocarcinoma in an endometriotic cyst. The patient was a 33‐year‐old woman with a large unilocular endometriotic cyst of the right ovary. On the internal wall of the cyst, both a plaque‐like protrusion with a papillary surface and a dome‐like mural nodule were noted. The former exhibited features of Müllerian adenosarcoma, and the latter showed those of clear cell adenocarcinoma. In the deeper portion of adenosarcoma, teratoma‐like tissue which contained various tissue components including primitive neuroectodermal tissue was found. The presence of primitive neuroectodermal tissue in the strom... Pathology International journals http://www.medworm.com/rss/comments.php?id=5585639 Fri, 13 Jan 2012 05:00:00 +0100 5585639 http://www.medworm.com/index.php?rid=5585638&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02781.x Neural cell adhesion molecule 1 (NCAM1), synaptophysin (SYPT), and chromogranin A (CGA) are immunohistochemical markers for diagnosing lung neuroendocrine tumors (LNETs). However, the precise expression mechanisms have not been studied in enough detail. The purpose of the present study is to define the molecular mechanisms of NCAM1, SYPT, and CGA gene expressions, using cultivated lung cancer cells and focusing upon NeuroD1 (ND1), achaete‐scute homolog‐like 1 (ASCL1), and known transcription factors, repressor element 1 (RE1)‐silencing transcription factor (REST) and c‐AMP responsive element‐binding protein (CREB). Promoter assays, chromatin immunoprecipitation, and transfection experiments revealed that ND1 activated NCAM1, that ASCL1 weakly upregulated SYPT expression, and that... Pathology International journals http://www.medworm.com/rss/comments.php?id=5585638 Fri, 13 Jan 2012 05:00:00 +0100 5585638 http://www.medworm.com/index.php?rid=5585642&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02779.x Plexiform lesions in pulmonary arteries are a characteristic histological feature for idiopathic pulmonary arterial hypertension (IPAH). The pathogenesis of the plexiform lesion is not fully understood, although it may be related to endothelial cell dysfunction and local inflammation. CD44 is a cell adhesion molecule and it is also involved in angiogenesis, endothelial cell proliferation and migration. The expression of CD44 was examined in lung plexiform lesions obtained from patients with IPAH (IPAH group, n= 7) and pulmonary arterial hypertension associated with atrial septal defect (ASD‐PAH group, n= 4). Expression of CD44 was detected in 49 out of 52 plexiform lesions (93%) from all patients in the IPAH group, whereas 31 plexiform lesions obtained from the ASD‐PAH group lacked CD4... Pathology International journals http://www.medworm.com/rss/comments.php?id=5585642 Tue, 10 Jan 2012 05:00:00 +0100 5585642 http://www.medworm.com/index.php?rid=5585637&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02764.x In conclusion, the present study showed that thymic MALT lymphoma has a characteristic pattern of chromosomal aberrations that may be similar to those of other autoimmune‐associated MALT lymphomas. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5585637 Sun, 01 Jan 2012 05:00:00 +0100 5585637 http://www.medworm.com/index.php?rid=5527626&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02749.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5527626 Thu, 22 Dec 2011 17:25:17 +0100 5527626 http://www.medworm.com/index.php?rid=5527625&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02750.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5527625 Thu, 22 Dec 2011 17:25:15 +0100 5527625 http://www.medworm.com/index.php?rid=5527624&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02741.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5527624 Thu, 22 Dec 2011 17:25:13 +0100 5527624 http://www.medworm.com/index.php?rid=5527623&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02745.x Primary squamous cell carcinoma of the thyroid (SCC‐T) is extremely rare. Its clinical presentation is similar to that of anaplastic carcinoma. Metastasis or extension from the head and neck area should be ruled out, as patients with SCC‐T have a poorer prognosis than patients who have a thyroid extension from an adjacent tumor. An 87‐year‐old man presented with a longstanding painless mass in the right thyroid and had experienced 2 months of pain upon swallowing. A right lobectomy was performed with resection of thyroid cartilage, cricoid cartilage, a portion of the first to third tracheal ring and the right neck lymph node. A histological examination revealed pure SCC. The tumor cells showed diffuse immunoreactivity to CK5/6, CK19 and p63. Immunoreactivity to EMA and p53 was fo... Pathology International journals http://www.medworm.com/rss/comments.php?id=5527623 Thu, 22 Dec 2011 17:25:04 +0100 5527623 http://www.medworm.com/index.php?rid=5527622&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02751.x This study also emphasizes the use of the postmortem needle biopsy technique whenever an autopsy is not possible. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5527622 Thu, 22 Dec 2011 17:25:02 +0100 5527622 http://www.medworm.com/index.php?rid=5527621&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02783.x To date, most of the proteomic analyses on lung cancer tissue samples have been performed using surgical specimens, which are obtained after a diagnosis is made. To determine if a proteomic signature obtained from bronchoscopic biopsy samples could be found to assist with diagnosis, 50 lung cancer bronchoscopic biopsy samples and 13 adjacent normal lung tissue samples were analyzed using histology‐directed, matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry (MS). Lung tissue samples were cryosectioned, and sinapinic acid was robotically deposited on areas of each tissue section enriched in epithelial cells, either tumor or normal. Mass spectra were acquired using a MALDI‐time of flight instrument. Small cell lung cancers (SCLCs) demonstrated clearly different prote... Pathology International journals http://www.medworm.com/rss/comments.php?id=5527621 Thu, 22 Dec 2011 17:25:00 +0100 5527621 http://www.medworm.com/index.php?rid=5478647&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02761.x We analyzed histopathological features of core needle biopsy (CNB) and surgical excision specimen comparatively in 129 patients with surgically proven phyllodes tumor (PT). Stromal characteristics including cellularity, atypia, mitosis, overgrowth, tissue fragmentation, and the tumor margin were assessed. Benign/borderline/malignant phyllodes tumor (PT) were diagnosed in 90 (69.8%)/30 (23.3%)/9 (7.0%) patients. Among the 90 cases of benign PTs, 67 cases (74.4%) were diagnosed concordantly in CNB. For borderline and malignant PTs, three out of eight (26.6%) and four out of nine (44.4%) cases were diagnosed concordantly in CNBs. All 50 cases of discordant diagnosis were underestimated in matched CNBs, especially in their stromal cellularity and mitosis. The size of tumor is larger in discord... Pathology International journals http://www.medworm.com/rss/comments.php?id=5478647 Thu, 01 Dec 2011 05:00:00 +0100 5478647 http://www.medworm.com/index.php?rid=5460318&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02770.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5460318 Thu, 01 Dec 2011 05:00:00 +0100 5460318 http://www.medworm.com/index.php?rid=5460317&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02769.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5460317 Thu, 01 Dec 2011 05:00:00 +0100 5460317 http://www.medworm.com/index.php?rid=5460316&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02762.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5460316 Thu, 01 Dec 2011 05:00:00 +0100 5460316 http://www.medworm.com/index.php?rid=5460315&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02724.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5460315 Thu, 01 Dec 2011 05:00:00 +0100 5460315 http://www.medworm.com/index.php?rid=5460314&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02738.x Intraductal papillary neoplasms of the bile duct are generally thought to arise from neoplastic papillary proliferation of epithelial cells lining the bile duct. We herein report a case with findings that strongly suggested that the biliary cystic tumor might have derived from a peribiliary gland. A 69‐year‐old female was found to have a cystic lesion with intracystic protrusions at the anterior segment of the right hepatic lobe and underwent hepatic anterior segment resection. Fluoroscopy of the resected specimen injected with contrast medium into the cyst revealed a connection between the cystic lesion and the bile ducts. The cyst was multilocular in appearance. On microscopic examination, the cyst was located within the portal tract of the inferior branch of the anterior segment and... Pathology International journals http://www.medworm.com/rss/comments.php?id=5460314 Thu, 01 Dec 2011 05:00:00 +0100 5460314 http://www.medworm.com/index.php?rid=5460313&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02748.x In conclusion, duodenal DLBCL predominantly exhibits GCB‐type tumors and the frequency of t(14;18) translocation appears to be higher in duodenal GCB‐type DLBCL compared to non‐duodenal tumors. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5460313 Thu, 01 Dec 2011 05:00:00 +0100 5460313 http://www.medworm.com/index.php?rid=5460305&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02766.x Cryptogenic organizing pneumonia (COP) is an idiopathic interstitial pneumonia characterized by fibroblastic tissues that occupy the lumina of alveoli and alveolar ducts or respiratory bronchioles. Although adequate doses and durations of glucocorticoids can improve its condition, COP is sometimes resistant to glucocorticoid therapy and is often lethal.Herein, a very rare case of ‘bronchiolar COP’ that was confined to the respiratory bronchioles is reported. This case indicates that macrolides may act as anti‐inflammatory agents in patients with COP. Timely and precise pathological diagnosis may corroborate clinician diagnoses and eventually improve chances to overcome the disease. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5460305 Thu, 01 Dec 2011 05:00:00 +0100 5460305 http://www.medworm.com/index.php?rid=5460308&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02758.x We report herein a rare variant case of a clear cell SCC originating in the esophagus. A 70‐year‐old Japanese man was found to have a tumor in the esophagus. The excised neoplasm showed dominance of clear cell over conventional SCC components; the two components in an apparent continuum. The clear cells, regular in size with a moderate nuclear/cytoplasmic ratio and relatively hyperchromatic and centrally located nuclei, were compactly arranged in sheets. Glycogen deposition was apparent on PAS staining with or without diastase digestion and under the electron microscope. The clear cell SCC components were positive for cytokeratin (CK)7, CK8, CK18 and CK19, but were negative for CK5/6 or CK14. Reciprocal staining patterns of CKs were apparent in conventional SCC components. The present ... Pathology International journals http://www.medworm.com/rss/comments.php?id=5460308 Wed, 30 Nov 2011 05:00:00 +0100 5460308 http://www.medworm.com/index.php?rid=5460307&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02759.x We report our first case of MASC in Japan occurring in the parotid gland of a 37‐year‐old female patient with a t (12; 15) (p13; q25) translocation. Histologically, the tumor was composed of monomorphic cuboidal cells with low‐grade vesicular nuclei and pale eosinophilic cytoplasm, and formed microcystic and tubular spaces with periodic acid‐Schiff‐positive secretion. Immunohistochemically, the tumor cells tested positive for cytokeratin, vimentin, and S‐100 protein. MASC is a morphological mimicker of acinic cell carcinoma, but is a distinct neoplasm characterized by a specific chromosomal translocation. An accumulation of similar case studies is mandatory in order to clarify biological behaviors. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5460307 Wed, 30 Nov 2011 05:00:00 +0100 5460307 http://www.medworm.com/index.php?rid=5460306&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02760.x Gastric cancer (GC) is one of the most common malignancies worldwide. Recently, cancer stem cells (CSCs) in tumors were found to possess the ability to sustain tumor self‐renewal, initiate tumor progression, and possibly also contribute to cancer metastasis. We immunohistochemically examined expression and distribution of representative CSC markers ALDH1, CD44, and CD133 in primary tumors and lymph node metastasis of GC. Among 190 GC primary tumors, 104 (55%) were positive for ALDH1, 117 (62%) were positive for CD44, and 18 (9%) were positive for CD133. Expression of these three CSC markers was significantly associated with advanced clinicopathologic factors. Patients with CD44‐ and CD133‐positive GC had a poorer survival rate than patients with CD44‐ and CD133‐negative GC (CD44:... Pathology International journals http://www.medworm.com/rss/comments.php?id=5460306 Wed, 30 Nov 2011 05:00:00 +0100 5460306 http://www.medworm.com/index.php?rid=5460312&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02755.x Histone H1, one of the histone superfamilies, is known to determine chromatin structure and alter gene expression. It also contributes to regulation of cell proliferation in breast cancer. We hypothesized a similar association in prostate cancer, and therefore examined relationships between histone H1 expression and Gleason pattern, Ki‐67 and androgen receptor levels in a series of prostate cancer tissues and cell lines. Histone H1 positive cancer cells increased with the Gleason pattern. Gleason pattern 3 tumors were divided into two groups, one with high histone H1 positivity (H1‐high cases, 60–100% positivity) and the other with low histone H1 positivity (H1‐low cases, 0–20% positivity). Ki‐67 or androgen receptor positivity in H1‐high cases was significantly higher than i... Pathology International journals http://www.medworm.com/rss/comments.php?id=5460312 Mon, 28 Nov 2011 05:00:00 +0100 5460312 http://www.medworm.com/index.php?rid=5460311&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02756.x Invasive diseases such as toxic shock syndrome caused by Streptococcus pyogenes (S. pyogenes) are re‐emerging infectious diseases. The mechanism of pathogenesis is not completely understood although the virulence of this organism has been analyzed using animal model systems, particularly using mice. The analysis of the progression of infection, however, is difficult. Computed tomography (CT) scanning is an extremely powerful technique that we applied to the mouse model of cutaneous infection with S. pyogenes. Two or three days after subcutaneous administration of bacteria, high density reticular areas were detected in the lung by CT. Histopathological examination of the lung was performed to examine the results of CT. Increased numbers of cytokeratin‐positive epithelial cells, prob... Pathology International journals http://www.medworm.com/rss/comments.php?id=5460311 Mon, 28 Nov 2011 05:00:00 +0100 5460311 http://www.medworm.com/index.php?rid=5460310&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02757.x Actinic cheilitis (AC) is an early keratocyte neoplasia with inflammation that occurs in the lip vermillion with the potential to develop into invasive squamous cell carcinoma (SCC). The expression of the intracellular enzyme indoleamine 2,3‐dioxygenase (IDO) by antigen‐presenting cells and/or tumor cells has been described to arrest T cell proliferation by degrading the essential amino acid tryptophan from the environment. The expression of IDO in AC may support cancer progression by inhibiting T cell‐mediated rejection responses. The aim of this study was to identify the cellular nature and extent of IDO expression in early keratocye neoplasia of the lower lip (n = 25), and to correlate IDO expression to the severity of epithelial atypia (KIN I°‐ KIN III°) and to the extent... Pathology International journals http://www.medworm.com/rss/comments.php?id=5460310 Mon, 28 Nov 2011 05:00:00 +0100 5460310 http://www.medworm.com/index.php?rid=5460309&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02765.x The recepteur d'origine nantais (RON) receptor tyrosine kinase is overexpressed in epithelial cancers, including gastric cancer. The aims of the present study were to evaluate whether RON affects tumor cell behaviors and oncogenic signaling pathways, and to document the relationship of its expression with various clinicopathological parameters in gastric cancer. The biological role of RON in tumor cell behaviors and oncogenic signaling pathways was investigated by using small interfering RNA in gastric cancer cell lines including AGS and MKN28. The expression of RON in gastric cancer tissues was investigated by using reverse transcription polymerase chain reaction and immunohistochemistry. Knockdown of RON suppressed tumor cell migration and invasion in AGS and MKN28, induced apoptosis thr... Pathology International journals http://www.medworm.com/rss/comments.php?id=5460309 Mon, 28 Nov 2011 05:00:00 +0100 5460309 http://www.medworm.com/index.php?rid=5450869&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02739.x For the detection of chromosome translocations/chimeric genes and specific genetic abnormalities in soft tissue tumors, we conducted fluorescence in situ hybridization (FISH) analysis on 280 cases of soft tissue and other tumors using formalin‐fixed paraffin‐embedded tissue sections. The detection rate of the FISH split‐signal was 84% (129/154 cases) for the translocation‐associated soft tissue tumors, such as Ewing's sarcoma/primitive neuroectodermal tumor, synovial sarcoma, alveolar rhabdomyosarcoma, myxoid liposarcoma, clear cell sarcoma and so forth. Positive split‐signals from EWSR1, SS18 and FOXO1A probes were detected in 3% (2/64) of various histological types of carcinoma, lymphoma, melanoma, meningioma and soft tissue tumors. In FISH using the INI1/CEP22 probe, the INI1 ... Pathology International journals http://www.medworm.com/rss/comments.php?id=5450869 Mon, 28 Nov 2011 05:00:00 +0100 5450869 http://www.medworm.com/index.php?rid=5443557&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02752.x Sclerosing epithelioid fibrosarcoma (SEF) is a rare but distinct variant of fibrosarcoma. A 43‐year‐old man presented with a lesion in his back that had been present for three years but had recently increased in size. Magnetic resonance imaging (MRI) revealed a 6‐cm sized ovoid mass showing low intensities on T1 and T2 weighted images. Histologically, the tumor was of moderate cellularity, and the cells were relatively uniform in size and shape. The cells were epithelioid, round, oval and polygonal with clear and slightly eosinophilic cytoplasm, forming nests, cords, or sheet‐like patterns with a dense collagenous and hyalinized matrix. The tumor was positive for vimentin, but negative for smooth muscle actin, desmin, HMB45, and CD34. Although the tumor showed nuclear overexpressio... Pathology International journals http://www.medworm.com/rss/comments.php?id=5443557 Thu, 24 Nov 2011 05:00:00 +0100 5443557 http://www.medworm.com/index.php?rid=5366889&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02740.x We examined two soft tissue myoepitheliomas, whose paraffin blocks were available, for fusion gene transcripts involving PLAG1 or HMGA2 specific for pleomorphic adenoma by a reverse transcription‐polymerase chain reaction assay, and no fusion transcripts were detected. Our results suggest that soft tissue myoepithelioma may be a pathogenetically distinct tumor entity from pleomorphic adenoma based on the absence of PLAG1 overexpression and characteristic fusion genes. On the other hand, PLAG1 immunohistochemistry is useful for distinguishing lipoblastoma from other lipomatous tumors including liposarcoma. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5366889 Thu, 03 Nov 2011 04:00:00 +0100 5366889 http://www.medworm.com/index.php?rid=5450868&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02736.x In conclusion, nodal follicular lymphoma with total loss or partially disrupted FDC networks therefore show a lower clinical stage. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5450868 Tue, 01 Nov 2011 04:00:00 +0100 5450868 http://www.medworm.com/index.php?rid=5443556&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02746.x We present the first documented case of a primary myoepithelial carcinoma in the trachea. The patient was a 23‐year‐old man who presented with shortness of breath and cough for four months. Bronchoscopy and computed tomographic (CT) scan revealed an intraluminal mass in the trachea. A standard sleeve of trachea resection with end‐to‐end reconstruction was performed. The tumor was mainly composed of spindle cells and epithelioid cells which exhibited relatively uniform nuclei with finely distributed chromatin and inconspicuous nucleoli, suggesting that it may arise from benign myoepithelioma. Moreover, the tumor displayed marked cytologic atypia and an infiltrative tumor border in some areas, suggesting that it was a malignant tumor. Immunohistochemically, the tumor cells were diffu... Pathology International journals http://www.medworm.com/rss/comments.php?id=5443556 Tue, 01 Nov 2011 04:00:00 +0100 5443556 http://www.medworm.com/index.php?rid=5366888&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02744.x In conclusion, Pin1 reduces acute liver injury of mice due to CCl4 by modulating apoptotic signals and by increasing NF‐kB activity. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5366888 Tue, 01 Nov 2011 04:00:00 +0100 5366888 http://www.medworm.com/index.php?rid=5366890&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02735.x Invasive micropapillary carcinoma (IMP) of the breast is a rare variant of invasive breast carcinoma and most cases of IMP are associated with nodal metastasis and lymphatic invasion. Lesions composed of an IMP component alone are rare and almost always coexist with other pathological components. However, few reports have documented IMP along with its proportion and the coexistent pathological type. We analyzed the total 486 breast cancer lesions operated in our hospital in 1998. We classified the lesions into five groups by the proportion of the IMP component in each lesion. Then we evaluated the incidence of nodal metastasis and lymphatic invasion in each group. The incidence of the invasive carcinoma containing any IMP components was 8.4%. The incidence of nodal metastasis and lymphatic... Pathology International journals http://www.medworm.com/rss/comments.php?id=5366890 Mon, 31 Oct 2011 04:00:00 +0100 5366890 http://www.medworm.com/index.php?rid=5350361&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02714.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5350361 Thu, 27 Oct 2011 05:34:48 +0100 5350361 http://www.medworm.com/index.php?rid=5350360&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02729.x A male neonate was clinically diagnosed with congenital intestinal atresia. Surgical operation was performed and the ileum including the atretic portion was resected. Grossly, there was a plaque‐like elevation of mucosa at the proximal side of the ileal atresia. Microscopic examination of this lesion revealed proliferation of severely atypical glands. Although dysplasia was a serious diagnostic concern, we concluded that ischemia due to the intestinal atresia induced this benign pseudodysplastic regenerative mucosa, judging from the pattern of coexisting inflammation and the literature review. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5350360 Thu, 27 Oct 2011 05:34:47 +0100 5350360 http://www.medworm.com/index.php?rid=5350359&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02721.x A comparison of the efficacy of the copper chelator, trientine, with combined renin angiotensin system (RAS) blockade on the progression of glomerular pathology in the diabetic (mREN‐2)27 rat is reported. Animals were treated for 2 months with trientine, combined RAS blockers, combined trientine plus RAS blockers or none. Treatments began after inducing diabetes with streptozotocin. Physiological data were recorded monthly and light microscopic glomerular features were scored. Plasma allantoin and both plasma and renal protein carbonyls were measured as markers of oxidative stress. Trientine and RAS blockade decreased proteinuria and albuminuria and prevented an increase in creatinine clearance and kidney weight. Both reduced the diabetes‐related glomerular features of mesangiolysis ... Pathology International journals http://www.medworm.com/rss/comments.php?id=5350359 Thu, 27 Oct 2011 05:34:37 +0100 5350359 http://www.medworm.com/index.php?rid=5350358&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02725.x Almost 70 years after the description of ‘collagen disease’ by P. Klemperer et al., it is still controversial whether the diversity and similarity of pathological manifestations among the collagen diseases depends on ambiguity in diagnosis or is an intrinsic quality of the collagen diseases themselves. A genome wide analysis of the MRL mouse models of collagen disease may shed some light on the complex pathological manifestations. Study of the susceptibility loci to each type ofcollagen disease (such as glomerulonephritis, vasculitis, arthritis, sialoadenitis and dacryoadenitis) in the mice, revealed that these lesions developed because of a cumulative effect of multiple gene loci, none of which can induce the related phenotype alone. This may indicate that collagen disease develop... Pathology International journals http://www.medworm.com/rss/comments.php?id=5350358 Thu, 27 Oct 2011 05:34:31 +0100 5350358 http://www.medworm.com/index.php?rid=5350357&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02734.x Mucins are high molecular weight glycoproteins that play important roles in carcinogenesis and tumor invasion. Our immunohistochemical studies demonstrated that MUC1 or MUC4 expression is related to the aggressive behavior and poor outcome of human neoplasms. MUC2 is expressed in indolent pancreatobiliary neoplasms, but these tumors sometimes show invasive growth with MUC1 expression in invasive areas. MUC5AC shows de novo high expression in many types of precancerous lesions of pancreatobiliary cancers and is an effective marker for early detection of the neoplasms. The combination of MUC1, MUC2, MUC4 and MUC5AC expression may be useful for early detection and evaluation of the potential for malignancy of pancreatobiliary neoplasms. Regarding the mechanism of mucin expression, we have rec... Pathology International journals http://www.medworm.com/rss/comments.php?id=5350357 Thu, 27 Oct 2011 05:34:19 +0100 5350357 http://www.medworm.com/index.php?rid=5366892&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02742.x In this report, we present a carcinoid tumor found in the thymic bronchogenic cyst of a 41‐year‐old female complaining of mild chest pain. The thymic tissue also shows follicular lymphoid hyperplasia. Atypical imaging features were found in her chest computed tomography. Additional 22 cases of bronchogenic cysts with malignant transformation were also reviewed from the literature. The clinicopathological data were summarized. The tumorigenesis of these tumors is unclear, but bronchogenic cysts of the lung may undergo malignant changes at a younger patient age and more frequently than mediastinal ones. Carcinoid tumors were also seemingly overrepresented in mediastinal cases. Some atypical imaging features may serve as clues for early detection and guide clinical management. (Source: Pa... Pathology International journals http://www.medworm.com/rss/comments.php?id=5366892 Thu, 27 Oct 2011 04:00:00 +0100 5366892 http://www.medworm.com/index.php?rid=5366891&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02747.x In conclusion, Only 17 cases of primary T/NK‐cell lymphoma of the salivary glands have been recorded until now, and the characteristics of these are not clear yet. Additional study is needed. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5366891 Thu, 27 Oct 2011 04:00:00 +0100 5366891 http://www.medworm.com/index.php?rid=5317312&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02737.x We report herein two cases of sclerosing PEComa; a distinctive variant of PEComa, which is characterized by extensive stromal hyalinization, occurring in the uterus and broad ligament. The patients were 34‐ and 51‐year‐old females with no family history of tuberous sclerosis complex. Macroscopically, the tumors had white to gray cut surfaces and were microscopically composed of predominantly spindle‐ to polygon‐shaped cells with clear to slightly eosinophilic cytoplasm and pleomorphic nuclei focally arranged in a perivascular pattern, accompanied by marked stromal hyalinization. These tumor cells were immunohistochemically positive for HMB45 and α‐smooth muscle actin. Although this variant of PEComa is very rare, this entity should be considered as a potential primary neoplasm... Pathology International journals http://www.medworm.com/rss/comments.php?id=5317312 Thu, 13 Oct 2011 04:00:00 +0100 5317312 http://www.medworm.com/index.php?rid=5306535&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02720.x Herein is reported a highly rare case of combined adenomatoid tumor and well differentiated papillary mesothelioma of the omentum. A 45‐year‐old Japanese man was incidentally found to have a mesenteric mass during abdominal ultrasonography. Grossly, a well‐circumscribed and non‐encapsulated tumor, measuring 24 × 23 × 22 mm, was located in the omentum with no obvious invasion to the surrounding stomach and pancreas. Microscopically, the tumor consisted of two histological distinct components; the majority of it showed irregular arrangement of numerous cysts lined by a single layer of flattened or epithelioid cells and the multifocal minor component exhibited prominent papillary protrusions lined by a single layer of cuboidal cells with relatively uniform nucleus. Immunohistochem... Pathology International journals http://www.medworm.com/rss/comments.php?id=5306535 Mon, 10 Oct 2011 04:00:00 +0100 5306535 http://www.medworm.com/index.php?rid=5338823&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02727.x Renal involvement is a significant complication of multicentric Castleman's disease (MCD) and various glomerular involvements have been reported. A 45‐year‐old Japanese man presented with persistent proteinuria, with lymphadenopathy and hypergammaglobulinemia. He had been diagnosed 4 years previously with MCD. As his renal impairment had progressed to renal failure, he underwent a renal biopsy. Histology revealed diffuse and global membranous lesions with large and heterogeneous epimembranous deposits. In addition, mesangial cell proliferation and focal extracapillary lesions were found. Under immunofluorescence, granular staining for anti‐IgG, IgG1, IgG2 and IgA was strongly positive in the capillary loop, and weakly positive in the mesangium. As such, there was a diversity of his... Pathology International journals http://www.medworm.com/rss/comments.php?id=5338823 Sat, 01 Oct 2011 04:00:00 +0100 5338823 http://www.medworm.com/index.php?rid=5317311&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02730.x Since the World Health Organization histological criteria were published in 1999, several studies have focused on adenosquamous carcinoma of the lung. Therefore, we aimed to clinicopathologically re‐evaluate this tumor using immunohistochemical methods. In our hospital, there have been 21 surgically resected adenosquamous carcinomas. The frequency of adenosquamous carcinoma was 1.9% and the clinical data including the patient prognosis data obtained in this study were similar to those reported previously. A fluorodeoxyglucose positron emission tomography study first revealed that the median maximum standardized uptake value of adenosquamous carcinoma was 9.3 and ranged from 2.0 to 24.5. According to the results of immunohistochemical staining for thyroid transcription factor‐1 (TTF‐1... Pathology International journals http://www.medworm.com/rss/comments.php?id=5317311 Sat, 01 Oct 2011 04:00:00 +0100 5317311 http://www.medworm.com/index.php?rid=5306534&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02726.x Tumor blood vessels play an important role in tumor progression and metastasis. Thus, targeting the tumor blood vessels is an important strategy in cancer therapy. Tumor blood vessels generally arise from pre‐existing vessels and have been thought to be genetically normal. However, they have been shown to differ from their normal counterparts, e.g. with regard to the morphological changes. We isolated tumor endothelial cells (TEC) from mouse tumor xenografts and showed that they were abnormal. TEC up‐regulate many genes, proliferate more rapidly and migrate more than normal endothelial cells (NEC). Furthermore, the TEC in our study were cytogenetically abnormal. We concluded that TEC can acquire cytogenetic abnormalities while in the tumor microenvironment. In order to develop ideal an... Pathology International journals http://www.medworm.com/rss/comments.php?id=5306534 Sat, 01 Oct 2011 04:00:00 +0100 5306534 http://www.medworm.com/index.php?rid=5276554&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02731.x The prognosis of urothelial carcinoma, micropapillary variant (MPV), of the bladder has been shown to be worse than that of the conventional urothelial carcinoma (UC). However, it remains to be clarified why the MPV is more aggressive. We therefore here focused on the correlation between clinical features and histological, immunohistochemical and molecular findings for eight MPV and 35 UC, evaluating expression of MUC1, Ki‐67, p53, CD147, CD34, D2‐40, and extracellular matrix proteins. The Ki‐67 labeling index was significantly higher in UC than in MPV but densities of venous and lymphatic tumor emboli were significantly higher in the MPV cases and lymph node metastasis was more frequent, with a poorer prognosis. Tenascin‐C and fibronectin also showed significantly greater expressi... Pathology International journals http://www.medworm.com/rss/comments.php?id=5276554 Sat, 01 Oct 2011 04:00:00 +0100 5276554 http://www.medworm.com/index.php?rid=5263293&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02712.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5263293 Thu, 29 Sep 2011 17:59:05 +0100 5263293 http://www.medworm.com/index.php?rid=5263292&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02743.x We previously reported that hepatocellular aging can be assessed by measuring the nuclear size of hepatocytes. We attempted to elucidate whether this method is useful to identify the high risk group of hepatocellular carcinoma (HCC) in the patients with non‐B non‐C non‐alcoholic liver injury. Fourteen patients with HCC and 78 without HCC, both of whom presented with non‐B non‐C non‐alcoholic chronic liver injury and underwent liver biopsy, were selected. Twelve histologically normal liver tissues were selected as controls. The relative nuclear size (RNS) was calculated as the average nuclear size of the hepatocytes divided by that of lymphocytes. Multiple clinicopathological parameters were studied. The RNS values of normal livers ranged from 1.32 to 2.10, showing a gradual inc... Pathology International journals http://www.medworm.com/rss/comments.php?id=5263292 Thu, 29 Sep 2011 17:58:53 +0100 5263292 http://www.medworm.com/index.php?rid=5263290&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02723.x We describe a patient who was diagnosed with classical Hodgkin lymphoma (CHL) at 67‐years‐old and peripheral T‐cell lymphoma, not otherwise specified (PTCL) at 76‐years‐old, and died 5 months later. Both tumors showed prominent epithelioid cell reaction admixed with neoplastic cells. Hodgkin and Reed–Sternberg cells in the swollen lymph node were positive for CD30 and EBV‐encoded RNA (EBER). PTCL cells in the skin tumor were positive for cytoplasmic CD3ε, CD4 and EBER. A rearrangement band of the T‐cell receptor gene was detected in the skin tumor. This case is the first documented EBV‐associated composite lymphoma composed of CHL and PTCL. The patient may show the possibility that both EBV infection and/or immunodeficiency induce the development of CHL and PTCL. (Sour... Pathology International journals http://www.medworm.com/rss/comments.php?id=5263290 Thu, 29 Sep 2011 17:58:35 +0100 5263290 http://www.medworm.com/index.php?rid=5263291&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02733.x In conclusion, we report first case of rhabdoid features in SNTCS. The present case showed an advanced stage and early recurrence; the rhabdoid component was probably responsible for this aggressive behavior. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5263291 Mon, 26 Sep 2011 04:00:00 +0100 5263291 http://www.medworm.com/index.php?rid=5252459&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02716.x Ribosomal proteins (RP) play key roles in the regulation of apoptosis, multidrug resistance and carcinogenesis. The aim of this study was to investigate the expression of ribosomal protein L36 (RPL36) in hepatocellular carcinoma (HCC) and to correlate it with clinicopathological parameters and clinical outcome. Liver specimens were obtained from 60 HCC patients who had undergone a partial hepatectomy. Expression of RPL36 in tumor tissue and surrounding non‐tumorous tissues was evaluated on a tissue microarray by immunohistochemistry. RPL36 was expressed in 45 of 60 (75%) HCC by immunohistochemistry, but was not detected in corresponding non‐tumors. RPL36 expression correlated significantly with serum levels of albumin (P= 0.044) and prothrombin time (P= 0.026), which reflect liver synt... Pathology International journals http://www.medworm.com/rss/comments.php?id=5252459 Fri, 23 Sep 2011 04:00:00 +0100 5252459 http://www.medworm.com/index.php?rid=5252458&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02718.x We present a case of atypical idiopathic retroperitoneal fibrosis (iRPF) presenting as a large pelvic tumor, for which it proved difficult to exclude T‐cell malignant lymphoma. Histopathological examination of biopsy material showed collagenous tissue and fat with an exuberant and predominant T‐cell infiltrate, largely consisting of CD4+ cells expressing the IL‐2 receptor‐α chain (CD25). Focal plasma cells were negative for the immunoglobulin G4 (IgG4) isotype. T‐cell receptor gene rearrangement (TRGR) pattern showed a Gaussian distribution, in keeping with a polyclonal T‐cell population. Awareness of the sometimes exuberant and predominant T‐cell infiltrate in iRPF should lead to earlier consideration of this disorder. This is particularly the case where there is an atypica... Pathology International journals http://www.medworm.com/rss/comments.php?id=5252458 Thu, 01 Sep 2011 04:00:00 +0100 5252458 http://www.medworm.com/index.php?rid=5228644&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02717.x Lymphocyte‐rich gastric cancer (Ly‐rich GC) is characterized by lymphoid stroma. To understand its formation, we studied the expression of a chemokine ligand (CCL)20 and its receptor CCR6 in 36 and 37 cases of Ly‐rich‐ and conventional GC, respectively. Lymphoid tissues in the alimentary tract were studied in parallel. By quantitative polymerase chain reaction, Ly‐rich GC contained CCL20 and CCR6 mRNAs at higher levels than conventional GC. By immunohistochemistry, CCL20 was expressed by cancer cells more frequently in Ly‐rich GC than in conventional GC. This was comparable with its expression in epithelial cells of the alimentary tract lymphoid tissues. CCR6 was mostly expressed by dendritic cells (DC) and B cells in Ly‐rich GC, which was also comparable with its expression ... Pathology International journals http://www.medworm.com/rss/comments.php?id=5228644 Thu, 01 Sep 2011 04:00:00 +0100 5228644 http://www.medworm.com/index.php?rid=5212506&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02732.x We report the second peritoneal case and this is the first case mainly involving the small bowel wall. A 65‐year‐old man showed diffuse involvement from the duodenum to the ileum and metastatic masses in the left adrenal gland. Segmental resection of the small bowel was performed; 2 months later the patient died. Light microscopy showed diffusely anaplastic epithelioid cell proliferation and foci of glandular formation with granular mucinous materials in the cytoplasmic vacuoles or within glandular lumina. Histochemically, these mucin materials were PAS‐positive and diastase‐resistant. Immunohistochemically, the various mesothelial markers were positive, and a few adenocarcinoma markers were focally positive. Ultrastructurally, the tumor cells showed long slender microvilli on th... Pathology International journals http://www.medworm.com/rss/comments.php?id=5212506 Thu, 01 Sep 2011 04:00:00 +0100 5212506 http://www.medworm.com/index.php?rid=5198445&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02715.x In conclusion, two‐dimensional analysis of elements is very useful for pathologists in correlating the presence of chemical elements with histological changes. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5198445 Wed, 31 Aug 2011 23:00:00 +0100 5198445 http://www.medworm.com/index.php?rid=5186242&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02722.x We present a case of stinging in the oral cavity caused by ingestion of the sperm bags of a squid. The patient experienced severe pain in her oral cavity immediately after eating raw squid. When she was examined at our hospital, we found that several small whitish spindle‐shaped stings were stuck to the mucous membrane of the hard palate. A biopsy was performed, and the whitish stings were removed as well. We also performed a histological examination of the remaining part of the raw squid brought by the patient. The biopsy showed that the sperm bags of the squid had thrust into the squamous epithelium of the patient. The remaining part of the raw squid consisted of the testis and the sperm bags. After removal of all stings, the pain reduced, and the wound healed in due course. Larva migr... Pathology International journals http://www.medworm.com/rss/comments.php?id=5186242 Wed, 31 Aug 2011 23:00:00 +0100 5186242 http://www.medworm.com/index.php?rid=5186244&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02713.x Composite lymphoma is defined as two or more distinct types of lymphoma in a single anatomical site. Among various combinations, composite B‐cell and T‐cell non‐Hodgkin's lymphomas (CBTL) are very infrequent. Herein we describe a 66‐year‐old female with CBTL presenting with lymphadenopathy, multiple bone lesions and an epidural tumor. Light microscopic examination of a biopsied cervical node revealed a dual population of lymphoid cells: sheets of large cells admixed with medium‐sized cells. The large cells expressed B‐cell markers and showed immunoglobulin light chain restriction, consistent with diffuse large B‐cell lymphoma (DLBCL). The medium‐sized cells were positive for CD20 as well as T‐cell markers. Because polymerase chain reaction amplification showed monoclona... Pathology International journals http://www.medworm.com/rss/comments.php?id=5186244 Mon, 29 Aug 2011 23:00:00 +0100 5186244 http://www.medworm.com/index.php?rid=5186243&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02719.x We report a case of gastrointestinal stromal tumor (GIST) of the stomach mimicking extragastrointestinal origin. The tumor presented as a large isolated mass in the transverse mesocolon with a minor adhesion to the stomach. Microscopic examination revealed c‐kit gene protein product (KIT)‐positive tumor cells with epithelioid features. The tumor pseudocapsule close to the adhesion site included a small smooth muscle tissue component, indicating a gastric origin. Furthermore, tumor cells at the adhesion site showed prominent hyalinization and calcification. The tumor was diagnosed as a gastric GIST showing extensive extramural growth. Thus, GIST of the stomach and other parts of the gastrointestinal tract can present as tumors localized in the soft tissues of the abdomen mimicking extra... Pathology International journals http://www.medworm.com/rss/comments.php?id=5186243 Mon, 29 Aug 2011 23:00:00 +0100 5186243 http://www.medworm.com/index.php?rid=5171620&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02728.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5171620 Mon, 29 Aug 2011 19:59:10 +0100 5171620 http://www.medworm.com/index.php?rid=5171619&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02697.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5171619 Mon, 29 Aug 2011 19:59:09 +0100 5171619 http://www.medworm.com/index.php?rid=5171618&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02689.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5171618 Mon, 29 Aug 2011 19:59:09 +0100 5171618 http://www.medworm.com/index.php?rid=5171617&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02702.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5171617 Mon, 29 Aug 2011 19:59:08 +0100 5171617 http://www.medworm.com/index.php?rid=5171616&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02710.x We present five patients who showed histopathological changes in the lungs consistent with mild PAP. However, these cases were notable for the abundance of degenerating alveolar macrophages, weak PAS staining of lipoproteinaceous material and paucity of lamellated bodies on ultrastructural examination. Only one patient showed the CT finding of mosaiform ‘crazy‐paving’ and the opalescent bronchoalveolar lavage fluid characteristic of PAP. In one case, therapeutic lung lavage based on a presumptive diagnosis of PAP exacerbated respiratory distress. Three patients showed partial or near‐complete resolution of disease in response to high‐dose corticosteroid therapy, a treatment approach that is generally ineffective in PAP. We conclude that distinguishing ‘variant alveolar lipoprot... Pathology International journals http://www.medworm.com/rss/comments.php?id=5171616 Mon, 29 Aug 2011 19:59:04 +0100 5171616 http://www.medworm.com/index.php?rid=5112285&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02705.x We report a case of invasive ductal adenocarcinoma of the pancreas with psammomatous calcification. A 57‐year‐old man was admitted to our hospital complaining of abdominal pain and vomiting. Carcinoma of the head of the pancreas was diagnosed based on precise clinical examinations. A subtotal stomach‐preserving pancreaticoduodenectomy was subsequently performed. Histological examination of the surgical specimen revealed a well‐differentiated adenocarcinoma composed of irregular tubular structures involving the head of the pancreas. Conspicuously, numerous tiny psammomatous‐type calcifications were observed, mainly within the neoplastic lumen, but also in association with carcinoma cells that had infiltrated the lymphatics and lymph nodes. In addition, expression of bone morphogen... Pathology International journals http://www.medworm.com/rss/comments.php?id=5112285 Mon, 08 Aug 2011 23:00:00 +0100 5112285 http://www.medworm.com/index.php?rid=5112284&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02706.x The heterozygous germline mutation of runt‐related protein 2 (RUNX2) causes cleidocranial dysplasia. To clarify the involvement of RUNX2 in human osteogenesis, fetal bones and various bone tumors were immunohistochemically examined. During both membranous and endochondral ossification in the fetus (n= 8), RUNX2 was expressed not only in osteoblastic cells but also in surrounding mesenchymal cells and early stage chondrocytes. Such an expression pattern was recapitulated in bone tumors: RUNX2 was unequivocally expressed in osteosarcoma (n= 20) and fibrous dysplasia (n= 10), regardless of the site of occurrence, cell morphology or amount of neoplastic osteoid. RUNX2 expression was limited to less differentiated cells in chondrogenic tumors (n= 20). We further analyzed whether RUNX2 express... Pathology International journals http://www.medworm.com/rss/comments.php?id=5112284 Mon, 08 Aug 2011 23:00:00 +0100 5112284 http://www.medworm.com/index.php?rid=5112286&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02711.x An extremely rare adult example of renal carcinoma with t(6;11)(p21;q12 or q13) is presented here. The tumor of a 45‐year‐old Japanese male, excised under the diagnosis of renal cell carcinoma, was a well circumscribed 7 cm mass with light brown sectioned surfaces. Histologically, it was composed of a major population of large polygonal epithelioid cells in a nested alveolar growth and a subpopulation of smaller cells clustering around hyaline basement membrane material. The former cells possessed ample, clear to eosinophilic granular cytoplasm with well‐defined cell borders and the latter was frequently accompanied by psammomatous calcification. These tumor cells exhibited immunoreactivity for melanoma markers, transcription factor EB and cathepsin K, but were not reactive for epi... Pathology International journals http://www.medworm.com/rss/comments.php?id=5112286 Sat, 06 Aug 2011 23:00:00 +0100 5112286 http://www.medworm.com/index.php?rid=5099412&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02707.x Tumor‐to‐tumor metastasis is a rare, but well‐recognized phenomenon. Here, we report a unique case of hepatocellular carcinoma (HCC) metastatic to parathyroid adenoma. A 53‐year‐old‐man with a history of HCC presented with hypercalcemia. It was found that he also had hyperparathyroidism with a hypoechoic mass in the lower portion of the right thyroid gland area. The patient underwent parathyroidectomy, and a mass measuring 1.5 × 1.0 cm was detected. Microscopic and immunohistochemical examination disclosed parathyroid adenoma with a focus of metastatic HCC. For the patient, it was the only distant metastasis revealed until the last follow‐up. To the best of our knowledge, this is the first reported case of tumor‐to‐tumor metastasis in which HCC is the donor. (Source: P... Pathology International journals http://www.medworm.com/rss/comments.php?id=5099412 Wed, 03 Aug 2011 23:00:00 +0100 5099412 http://www.medworm.com/index.php?rid=5134188&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02709.x A 48 year‐old African American woman presented to her physician complaining of a rapidly evolving epigastric and right upper quadrant abdominal pain. A PET‐CT of the abdomen and pelvis demonstrated hypermetabolic, polypoid masses within the gallbladder and several tumors in the left lobe of the liver for which she underwent diagnostic laparoscopy. The gallbladder revealed a 3.5 × 3.3 × 2.4 tan‐brown exophytic mass located at the fundus and growing into the lumen with multiple contiguous papillary projections arising from the mucosal surface. A concurrent large cell neuroendocrine carcinoma and papillary adenocarcinoma of the gallbladder was revealed histologically. There was shared reactivity to antibodies directed against the distinct antigens for each morphological component wi... Pathology International journals http://www.medworm.com/rss/comments.php?id=5134188 Sun, 31 Jul 2011 23:00:00 +0100 5134188 http://www.medworm.com/index.php?rid=5112283&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02728.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5112283 Sun, 31 Jul 2011 23:00:00 +0100 5112283 http://www.medworm.com/index.php?rid=5099411&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02708.x Pituicytoma is a rare low‐grade glial neoplasm that originates in the neurohypophysis or infundibulum. Because of its rare occurrence, the morphology and differentiation of pituicytoma have not been fully clarified. Here, we report a case of pituicytoma with unusual histological features mimicking ependymoma, but exhibiting the diverse morphology and differentiation of pituicytoma. The 1.4 cm‐sized suprasellar mass was incidentally found in the magnetic resonance image of a 42‐year‐old Korean woman who had had a traffic accident. Four years later, she presented with symptoms of hypopituitarism and the follow‐up images revealed slight enlargement of the mass. After gross total resection, microscopic examination revealed oval to elongated cells with abundant eosinophilic cytoplas... Pathology International journals http://www.medworm.com/rss/comments.php?id=5099411 Sun, 31 Jul 2011 23:00:00 +0100 5099411 http://www.medworm.com/index.php?rid=5090256&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02695.x Macrophages can be polarized to exhibit either pro‐inflammatory M1 or pro‐angiogenic M2 phenotypes, but have high phenotypic plasticity. This pilot study investigated macrophage polarization in the macular retina and choroid of age‐related macular degeneration (AMD) and non‐AMD subjects, as well as in AMD choroidal neovascular membranes (CNVM). All specimens were evaluated for routine histopathology. Quantitative real‐time polymerase chain reaction for representative M1 (CXCL11) and M2 (CCL22) transcripts were performed on macular choroidal trephines (MCT) of 19 AMD and nine non‐AMD eye bank eyes, on the microdissected macular retinal cells from the archived slides of five geographic atrophic AMD, five exudative/neovascular AMD, and eight normal autopsied eyes, and on microdiss... Pathology International journals http://www.medworm.com/rss/comments.php?id=5090256 Sun, 31 Jul 2011 23:00:00 +0100 5090256 http://www.medworm.com/index.php?rid=5090255&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02696.x We here report two cases of solitary fibrous tumor (SFT) arising in the prostate. Two men, 66 and 69 years old, with urinary tract symptoms were diagnosed with SFT on transrectal needle biopsy and transurethral resection of the prostate, respectively. The tumors were removed by a low anterior resection including tumor, prostate and rectum en bloc and cystoprostatectomy, respectively. Both tumors were well‐circumscribed but also showed some infiltration of the prostate glands. They were composed of storiform bundles of bland spindle cells that stained strongly for CD34 and vimentin but negative for muscle markers. Although rare, SFT should be considered as differential diagnosis of spindle cell lesions on prostate biopsies. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5090255 Sun, 31 Jul 2011 23:00:00 +0100 5090255 http://www.medworm.com/index.php?rid=5065403&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02692.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5065403 Wed, 27 Jul 2011 05:14:55 +0100 5065403 http://www.medworm.com/index.php?rid=5065402&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02685.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5065402 Wed, 27 Jul 2011 05:14:53 +0100 5065402 http://www.medworm.com/index.php?rid=5065401&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02694.x There is limited data regarding the association between the expression of cell cycle‐regulating molecules and the response of patients with urothelial carcinoma in situ (CIS) to bacillus Calmette–Guerin (BCG) therapy. To examine the relationship between p16, pRb and p53 expression in bladder CIS and patient response to initial BCG therapy, we performed immunohistochemical studies for 27 patients with bladder CIS. Overexpression of p16, pRb, and p53 was observed in 37%, 41%, and 48% of patients, respectively. Initial BCG therapy was effective in 21 patients (78%). Coexistence of papillary urothelial carcinoma, depth (pTa or pT1) and grade of coexisting papillary carcinoma did not affect the response to BCG therapy. pRb overexpression had a significant relationship to poor response to BC... Pathology International journals http://www.medworm.com/rss/comments.php?id=5065401 Wed, 27 Jul 2011 05:14:38 +0100 5065401 http://www.medworm.com/index.php?rid=5065400&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02698.x A 78‐year‐old retired woman was diagnosed with metaplastic breast carcinoma (MBC), a rare tumor, in our hospital. We reviewed 15 articles with a total of 1328 patients to determine the epidemiology, clinical features, biomarkers, histology, management and outcome of patients with this tumor. The mean age at presentation is 58.5 years (range 32–83). Eighty‐one percent of patients presented either with a breast mass or abnormal mammographic finding. Twenty‐three percent of patients had a family history of breast cancer. Estrogen receptors were only found in 12%, progesterone receptors in 10% and HER2 in 6% of patients. The main method of treatment was mastectomy (66.9%) in combination with chemotherapy (57%) and radiotherapy (47%). Five‐year disease‐free survival ranged betwe... Pathology International journals http://www.medworm.com/rss/comments.php?id=5065400 Wed, 27 Jul 2011 05:14:15 +0100 5065400 http://www.medworm.com/index.php?rid=5023216&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02699.x Abdominal aortic aneurysm (AAA) is a common disease caused by segmental weakening of the aortic walls and progressive aortic dilation leading to the eventual rupture of the aorta. Currently no biomarkers have been established to indicate the disease status of AAA. Tenascin‐C (TN‐C) is a matricellular protein that is synthesized under pathological conditions. In the current study, we related TN‐C expression to the clinical course and the histopathology of AAA to investigate whether the pattern of TN‐C expression could indicate the status of AAA. We found that TN‐C and matrix metalloproteinase (MMP)‐9 were highly expressed in human AAA. In individual human AAA TN‐C deposition associated with the tissue destruction, overlapped mainly with the smooth muscle actin‐positive cells... Pathology International journals http://www.medworm.com/rss/comments.php?id=5023216 Mon, 11 Jul 2011 23:00:00 +0100 5023216 http://www.medworm.com/index.php?rid=5023215&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02700.x Squamous cells in the thyroid appear in a variety of conditions, including adenomatous goiters, malignant neoplasms, inflammatory diseases, and embryonic remnants. However the origin of the squamous cells is still under dispute. Here we report a case of an encapsulated follicular cell tumor consisting of follicular cells, basaloid squamous cells, and morphologically intermediate cells. The patient was a 66‐year‐old man presenting with a progressively enlarged painless lump in the right side of his neck. A solid tumor with encapsulation in the right lobe was confirmed by simple right lobe thyroid lobectomy. This tumor demonstrated heterogeneous immunoreactions for Ki‐67, thyroglobulin, thyroid transcription factor‐1, and pan‐cytokeratin (AE1/AE3), in that the intermediate cells ha... Pathology International journals http://www.medworm.com/rss/comments.php?id=5023215 Mon, 11 Jul 2011 23:00:00 +0100 5023215 http://www.medworm.com/index.php?rid=5023214&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02703.x A 72‐year‐old male visited the hospital with a complaint of dyspnea. Under the diagnosis of pulmonary hypertension (PH) due to chronic thrombotic and/or embolic disease, this patient received anti‐coagulant therapy. Unfortunately, the respiratory state deteriorated and died 34 days after admission. At autopsy, noncaseating granulomas, which were diagnostic of sarcoidosis, were found in bilateral enlarged hilar lymph nodes, lungs, heart, liver, spleen, testis and epididymis. In pulmonary vasculature, the following three kinds of lesions were observed; (i) sarcoid granulomatous vasculitis at the peripheral arteries and veins, (ii) intimal fibrous lesions ubiquitously found in proximal and peripheral arteries which were thought to be organized thromboemboli, (iii) Takayasu‐like larg... Pathology International journals http://www.medworm.com/rss/comments.php?id=5023214 Mon, 11 Jul 2011 23:00:00 +0100 5023214 http://www.medworm.com/index.php?rid=5054471&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02691.x We present a case of a FNH associated with serum AFP increase, and in which both the lesion and the non‐lesional adjacent liver showed AFP‐positive immunostained areas. Moreover, only one case of FNH with AFP‐positive immunostaining has been previously reported. In addition, our case of FNH is remarkable as it displayed some morphological and immunophenotypical features of progenitor cells. The serum AFP levels rose after liver resection and progressively returned to the preoperative high values. These findings are concordant with the hypothesis that FNH is a regenerative process, and suggest that regenerative areas in the liver might be the source of AFP production. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5054471 Thu, 30 Jun 2011 23:00:00 +0100 5054471 http://www.medworm.com/index.php?rid=5023213&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02704.x In conclusion, the kidney is a potential target of chronic GVHD that may induce the development of HSCT‐associated TMA. Importantly, some cases are associated with chronic humoral GVHD. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5023213 Thu, 30 Jun 2011 23:00:00 +0100 5023213 http://www.medworm.com/index.php?rid=5012665&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02701.x We report here a case of thyroid papillary carcinoma showing unique morphology in IgG4‐RSD. Solid tumor nests were surrounded by dense IgG4‐positive plasma cells and fibrosis at both the primary site and metastatic lymph nodes. In contrast the background thyroid showed focal lymphocytic thyroiditis. IgG4‐related sclerosing sialadenitis and autoimmune pancreatitis were also diagnosed, and prednisolone treatment improved symptoms and serum IgG4 abnormality. To the best of our knowledge, this is the first documentation of a malignancy of the thyroid gland occurring in a background of IgG4‐RSD. A brief review of the literature on the relationship between IgG4 and malignancy is included. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=5012665 Thu, 30 Jun 2011 23:00:00 +0100 5012665 http://www.medworm.com/index.php?rid=5001862&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02684.x Autoimmune pancreatitis (AIP) (also called IgG4‐related sclerosing pancreatitis (IgG4‐SP)) and IgG4‐related sclerosing cholangitis (IgG4‐SC) are frequently associated with each other. It is generally believed that association of these diseases with pancreatobiliary malignancy is, however, rare. Here, we report on the case of a patient with AIP whose biliary cytology revealed severely atypical cells. Surgically resected specimens from this patient showed typical AIP with IgG4‐SC, as well as a mildly elevated lesion in the common bile duct with varying degrees of cellular atypia. In addition, the atypical cells tested positive for the mucin‐core protein, MUC5AC and p53 overexpression. These findings led us to diagnose the common bile duct lesion as biliary intraepithelial neoplas... Pathology International journals http://www.medworm.com/rss/comments.php?id=5001862 Thu, 30 Jun 2011 23:00:00 +0100 5001862 http://www.medworm.com/index.php?rid=4988037&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02693.x We report a case of papillary adenoma of the lung with a peculiar raw macroscopic feature at intraoperative consultation. A 52‐year‐old man was admitted to our hospital for the evaluation of a solitary peripheral nodule in the left lower lobe which was detected with chest CT. When we took staples off from the stump of the partially resected lung in order to make a frozen section diagnosis, granular fragments leaked out from the stump. On the cut surface, the dark reddish and granular tumor grew expansively; however, hemorrhage and necrosis were absent. Histologically, granular fragments were mainly composed of papillary structures, which consisted of a single layer of cuboidal to low columnar cells with round to oval nuclei lining the surface of the fibrovascular cores. Characteristica... Pathology International journals http://www.medworm.com/rss/comments.php?id=4988037 Thu, 30 Jun 2011 23:00:00 +0100 4988037 http://www.medworm.com/index.php?rid=4979015&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02687.x We present here a 56‐year‐old woman with PV harboring a JAK2V617F mutation that had a diffuse reticulonodular pattern on chest radiography and was initially suspected of having military tuberculosis. Pathological assessment of a video‐assisted thoracoscopic surgery lung biopsy revealed that the lesions were in fact organizing pneumonia (OP). Interestingly, pulmonary extramedullary hematopoiesis with a diffuse plugging of the alveolar blood capillaries by numerous atypical megakaryocytes was also observed around the granulation components. The histological findings of our case of unusual OP suggest that local activated neoplastic megakaryocytes and platelets played an important role in the development of spreading fibrotic lesions. JAK2 mutation or the preleukemic phase of MPN may acc... Pathology International journals http://www.medworm.com/rss/comments.php?id=4979015 Wed, 29 Jun 2011 22:24:33 +0100 4979015 http://www.medworm.com/index.php?rid=4972003&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02682.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4972003 Tue, 28 Jun 2011 01:22:55 +0100 4972003 http://www.medworm.com/index.php?rid=4972002&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02680.x In this study, we correlated the number of tryptase‐reactive mast cells with the number of CD8‐positive T cells in human endometrial adenocarcinoma biopsy specimens by means of immunohistochemical techniques. Results have shown that CD8‐positive T cell counts correlate to tryptase‐positive mast cell counts and that these parameters increase in accordance with the tumor progression of human endometrial carcinoma. These data suggest that inhibition of inflammation or manipulation of inflammatory resolution pathways may be a new therapeutic approach for the treatment of endometrial adenocarcinoma. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4972002 Tue, 28 Jun 2011 01:22:54 +0100 4972002 http://www.medworm.com/index.php?rid=4972001&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02690.x To evaluate the pathophysiological mechanisms underlying sudden infant death syndrome (SIDS), four sudden unexpected death in infancy (SUDI) and four sudden deaths in children over 1 year of age were examined. In the SUDI cases, increased numbers of scavenger receptor A positive (SRA+) cells (4/4), numerous platelet aggregates (3/4), and tumor necrosis factor (TNF)‐α+ cells (4/4) were observed in the peripheral blood (PB) smear preparations. Macrophage colony stimulating factor, interleukin (IL)‐6, IL‐8, TNF‐α and IL‐1β all exceeded the normal levels. Minute foci of inflammatory lung injury (4/4), numerous platelet emboli in lungs and among cardiac myocytes (3/4) and appreciable contraction band necrosis (1/4) were observed. And neutrophils accumulated in the capillaries of ... Pathology International journals http://www.medworm.com/rss/comments.php?id=4972001 Tue, 28 Jun 2011 01:22:47 +0100 4972001 http://www.medworm.com/index.php?rid=4963458&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02683.x We established a dedifferentiated liposarcoma cell line (NDDLS‐1) that produces interleukin‐6 (IL‐6) and granulocyte‐colony stimulating factor (G‐CSF). The parental tumor showed high leukemoid reactions. The NDDLS‐1 cell line was established from a pleural effusion associated with a lung metastasis. Pleomorphic tumor cells arranged in a haphazard growth pattern were seen in xenograft tumors. Numerous inflammatory cells including neutrophils or eosinophils were present throughout the tumor cells. This finding resembled the dedifferentiated area of the parental tumor. The mice bearing NDDLS‐1 showed marked leukocytosis. In addition, the NDDLS‐1 cells expressed IL‐6 and G‐CSF at both the mRNA and protein levels, while the NDDLS‐1 cells produced near normal levels of tumo... Pathology International journals http://www.medworm.com/rss/comments.php?id=4963458 Tue, 21 Jun 2011 23:00:00 +0100 4963458 http://www.medworm.com/index.php?rid=4963457&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02686.x To date, protein profiles for hepatocellular carcinomas and cholangiocarcinomas have not been systematically evaluated and compared with each other in an unbiased way. Thirty‐six hepatocellular carcinomas and adjacent normal tissue samples were analyzed using histology‐directed, matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry (MS). Four cholangiocarcinomas and adjacent normal tissue samples were also evaluated. Tissue samples were sectioned at 10 µm, with 1–3 sections thaw‐mounted on a conductive indium tin oxide‐coated glass slide. Sinapinic acid was manually deposited on areas of each tissue section enriched by epithelial cells, either tumor or normal, and mass spectra were acquired using a MALDI‐time of flight instrument. According to class predict... Pathology International journals http://www.medworm.com/rss/comments.php?id=4963457 Tue, 21 Jun 2011 23:00:00 +0100 4963457 http://www.medworm.com/index.php?rid=4963456&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02688.x Recent improvements in cell purification and transplantation techniques have contributed to the identification of cell populations known as tumor‐initiating cells (TIC). This discovery has led to the ‘cancer stem cell hierarchy’ concept, which holds that tumors are organized as a hierarchy of malignant tissues sustained by such TIC. However, this concept remains controversial. In this review, we examine recent advances in cancer stem cell research that have been generated from studies of Philadelphia (Ph) chromosome‐positive leukemia. The abnormal Ph chromosome, which arises from a translocation creating the BCR‐ABL1 fusion gene, is most commonly associated with chronic myelogenous leukemia (CML) and precursor B cell acute lymphoblastic leukemia (B‐ALL). Examination of the path... Pathology International journals http://www.medworm.com/rss/comments.php?id=4963456 Tue, 31 May 2011 23:00:00 +0100 4963456 http://www.medworm.com/index.php?rid=4925457&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02673.x The characteristics of lymphangiogenesis in preneoplastic and neoplastic lesions of the uterine cervix are not well known and the role of this process in tumor progression and metastasis is not well understood. The aim of the present study was to characterize the morphology and distribution of lymphatic vessels and lymphatic proliferative status and to evaluate the value of lymphatic microvascular density (LMVD) in premalignant and malignant lesions of the uterine cervix. One hundred and twenty‐eight paraffin‐embedded cervical specimens were immunostained with D2‐40 antibody specific for lymphatic endothelial cells. Colocalization of D2‐40 and Ki67 for the proliferative characterization of lymphatic vessels was obtained by performing double immunostaining. A low density of lymphati... Pathology International journals http://www.medworm.com/rss/comments.php?id=4925457 Tue, 31 May 2011 23:00:00 +0100 4925457 http://www.medworm.com/index.php?rid=4916045&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02675.x In this study, we evaluated ERG expression using antibody‐based detection in 230 prostate specimens in a Japanese PCa cohort. Overall, we identified 20.1% ERG‐positive PCa cases. ERG was not detected in benign glands. The specificity of ERG staining for detecting PCa was almost 100%; all of the ERG‐positive samples were also diagnosed as PCa. The expression level of the ERG protein correlated with clinicopathological variables, including grade (P= 0.038), stage (P= 0.005), and metastatic status (P= 0.014). No correlation was observed with age (P= 0.196) or with preoperative prostate‐specific antigen level (P= 0.322). Although the frequency of ERG‐positive cases in Japanese PCa patients (20.1%) was lower than that reported in a PCa cohort in Western countries (approximately 50%), ... Pathology International journals http://www.medworm.com/rss/comments.php?id=4916045 Tue, 31 May 2011 23:00:00 +0100 4916045 http://www.medworm.com/index.php?rid=4887642&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02677.x In conclusion, APGC formed a distinct subset and should be considered separately from lung adenocarcinoma based on frequent involvement of the left and lower lung and lack of central fibrosis. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4887642 Tue, 31 May 2011 23:00:00 +0100 4887642 http://www.medworm.com/index.php?rid=4866926&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02664.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4866926 Fri, 27 May 2011 16:23:08 +0100 4866926 http://www.medworm.com/index.php?rid=4866925&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02663.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4866925 Fri, 27 May 2011 16:23:07 +0100 4866925 http://www.medworm.com/index.php?rid=4834770&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02674.x Retinoids regulate cell proliferation and differentiation in normal and neoplastic tissue. These effects are mainly mediated by two types of nuclear retinoid receptors, retinoic acid receptors (RAR) and retinoid X receptors (RXR). RXR have been demonstrated to play important roles in esophageal carcinoma, but the expression of RXRβ and RXRγ has not been examined in esophagus. Therefore, we examined the immunoreactivity of all subtypes of RAR and RXR in 53 non‐neoplastic esophageal epithelium and 74 esophageal squamous cell carcinoma tissues. In non‐neoplastic epithelium RARβ immunoreactivity was marked in the basal layer and weak in the suprabasal layer, but immunoreactivity of other retinoid receptors was detected in both of layers. In addition, the status of RARβ and RXRβ immuno... Pathology International journals http://www.medworm.com/rss/comments.php?id=4834770 Tue, 17 May 2011 23:00:00 +0100 4834770 http://www.medworm.com/index.php?rid=4834769&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02678.x In this report, we propose that the term duplication should be uniformly used for all cases in the digestive organs, and that they may then be distinguished according to their mechanisms. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4834769 Tue, 17 May 2011 23:00:00 +0100 4834769 http://www.medworm.com/index.php?rid=4834771&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02681.x We report herein two cases of primary KHE occurring in a long bone without cutaneous changes with long‐term follow up in young patients. The patients were a 9‐year‐old girl and 5‐year‐old boy presenting with lytic lesions of the femur and humerus, respectively, without cutaneous lesions. Histologically, the neoplasms were comprised of nodules of spindle‐ to oval‐shaped cells growing in an infiltrative fashion. The neoplastic cells formed poorly canalized or slit‐like blood vessels alternating with solid spindle areas. Immunohistochemical studies showed that the tumor cells expressed CD31, CD34 and Fli1, but not HHV8, LNA‐1 or GLUT1. D2‐40 stained the neoplastic spindle cells and lymphatic channels adjacent to vascular lobules. The girl remains well with 15 years and 6... Pathology International journals http://www.medworm.com/rss/comments.php?id=4834771 Sun, 15 May 2011 23:00:00 +0100 4834771 http://www.medworm.com/index.php?rid=4777082&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02666.x Malignant mesothelioma (MM) is an aggressive tumor arising primarily from pleural or peritoneal cavities, which is caused by asbestos exposure after long latency. One of the most frequently mutated genes detected in MM cells is the neurofibromatosis type 2 (NF2) tumor suppressor gene which is located at chromosome 22q12. The NF2 gene encodes Merlin, an ERM (Ezrin/Radixin/Moesin) protein. The underphosphorylated form of Merlin is active and acts as a tumor suppressor by regulating several distinct cellular signaling pathways. One of the downstream pathways regulated by Merlin is the Hippo signaling pathway, which is conserved from Drosophila to mammalian cells and plays important roles in organ size control and cancer development. Recent studies have identified alterations of the components... Pathology International journals http://www.medworm.com/rss/comments.php?id=4777082 Sun, 01 May 2011 23:00:00 +0100 4777082 http://www.medworm.com/index.php?rid=4777081&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02671.x Histiocytic sarcoma (HS) is a malignant neoplasm showing the morphological and immunophenotypic features of mature histiocytes. Reported herein is a case of HS of the parotid gland region. A 53‐year‐old woman noticed a swelling of the right preauricular area. Preoperative fine needle aspiration cytology showed an admixture of pleomorphic atypical cells and mature lymphocytes. She underwent total parotidectomy. Grossly, the tumor was located at the parotid gland to subcutaneous tissue, and showed infiltrative growth with massive necrosis and hemorrhage. Microscopically, the tumor was composed of marked pleomorphic cells with eosinophilic cytoplasm. Bizarre multinuclear giant cells were scattered and intermingled. Tumor cells were positive for CD68 (KP‐1 and PG‐M1), CD163, S‐100 pr... Pathology International journals http://www.medworm.com/rss/comments.php?id=4777081 Sun, 01 May 2011 23:00:00 +0100 4777081 http://www.medworm.com/index.php?rid=4856913&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02679.x Cancer‐to‐cancer metastasis into a thyroid neoplasm is an uncommon phenomenon with possible diagnostic difficulties. Here, we describe a case of lung adenocarcinoma metastatic into a follicular variant of papillary thyroid carcinoma (FVPTC). A 60‐year‐old woman with no prior history of malignant neoplasm presented with a nodule in the right lobe of the thyroid gland, some masses in the left lung were found by radiological examination. Histopathological examination of the thyroidectomy specimen demonstrated two different components of carcinoma in a single thyroid nodule; one was FVPTC and the other was high‐grade adenocarcinoma. Although both components shared the TTF‐1+/CK7+/CK19+/CK20−/SP‐A− immunoprofile, only the former was positive for thyroglobulin, and only the lat... Pathology International journals http://www.medworm.com/rss/comments.php?id=4856913 Sat, 30 Apr 2011 23:00:00 +0100 4856913 http://www.medworm.com/index.php?rid=4834768&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02676.x Matrix‐producing carcinoma (MPC) of the breast is an extremely rare variant of metaplastic carcinoma. The aim of this study was to evaluate the clinicopathological features and immunohistochemical expression profile of this rare tumor in Chinese population. Thirteen cases of MPC were evaluated using morphology observation and immunohistochemistry. All tumors had invasive carcinoma with an abrupt transition to chondromyxoid matrix without an intervening spindle cell sarcomatoid component. The distribution of tumor cells was diffuse in eight cases and peripheral in five cases. Matrix distribution was diffuse or multifocal. Necrosis was present in 11 cases. An overt invasive ductal carcinoma was observed in 11 cases and the other two tumors were consistent with MPC arising in microglandular... Pathology International journals http://www.medworm.com/rss/comments.php?id=4834768 Sat, 30 Apr 2011 23:00:00 +0100 4834768 http://www.medworm.com/index.php?rid=4784658&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02667.x Excessive amounts of melanin pigments may hamper histopathological assessments of melanocytic lesions by obscuring cellular morphology and hindering antibody–antigen interactions. To determine the optimal melanin‐bleaching conditions for histopathological examination, heavily pigmented melanomas were treated with warm hydrogen peroxide (H2O2) diluted with various diluents (1% disodium hydrogen phosphate 12H2O ( (Na2 HPO4); phosphate buffer 0.05 M, pH 7.4 (PB); and PBS 0.05 M, pH 7.4) at varying temperatures (50°C, 55°C, and 60°C) and for varying incubation times (0.5, 1, 2, and 3 h). The effect of the sequential order of antigen retrieval and bleaching on preserving tissue morphology was then evaluated. Additionally, the effect of melanin bleaching using warm diluted H2O2 on t... Pathology International journals http://www.medworm.com/rss/comments.php?id=4784658 Sat, 30 Apr 2011 23:00:00 +0100 4784658 http://www.medworm.com/index.php?rid=4777080&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02672.x Herein is presented a very rare case of alveolar rhabdomyosarcoma in the uterine corpus of a 72‐year‐old woman. The wall of the uterine corpus was replaced by multiple whitish–yellow, friable nodules, measuring up to 6 cm. Microscopically, the tumor was predominantly composed of round to polygonal cells arranged in an alveolar, papillary or nest pattern intermingled with multinuclear giant cells with abundant eosinophilic cytoplasm. Extensive sampling failed to show epithelial elements. Immunohistochemically, the tumor was positive for striated muscle markers such as myoglobin, myoD1 and myogenin. Metastatic lesions were found in the retroperitoneum and pelvic lymph nodes. The patient was treated by postoperative chemotherapy, but she died of systemic metastases 12 months after s... Pathology International journals http://www.medworm.com/rss/comments.php?id=4777080 Sat, 30 Apr 2011 23:00:00 +0100 4777080 http://www.medworm.com/index.php?rid=4755824&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02670.x We report here a 53‐year‐old woman with PJS who developed multiple hamartomatous polyps in the jejunum and mucinous glandular lesions in multiple organ systems: glandular metaplasia in the urinary bladder; lobular endocervical glandular hyperplasia in the uterine cervix; mucinous metaplasia in the right fallopian tube; mucinous adenoma in the left ovary. Histological and immunohistochemical analyses disclosed that all of the intestinal and extra‐intestinal lesions were associated with pyloric gland metaplasia/differentiation across the organ systems. In the general population, the organs described above rarely or infrequently show pyloric gland phenotype, to say nothing of trans‐organ involvement. It is strongly suggested that commitment to pyloric gland metaplasia/differentiation ... Pathology International journals http://www.medworm.com/rss/comments.php?id=4755824 Wed, 27 Apr 2011 21:23:55 +0100 4755824 http://www.medworm.com/index.php?rid=4755826&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02668.x To examine the relationship between the scavenger receptor A (SRA) index (the number of SRA+ cells observed in 10 high power fields of peripheral blood (PB) smear samples; normal upper limit <30) and coronary thrombus, 389 thrombi obtained from 393 patients with acute ST elevation myocardial infarction were examined. Thrombi were classified into platelets (PT), mixed (MT), fibrin‐rich (FT) and organizing thrombi (OT); 387, 269, 57 and 29 cases were detected, respectively. Patients were divided into group A (PT only, 89 cases), B (containing MT and PT but not FT, 243 cases), and C (containing FT, 57 cases). SRA+ cells had infiltrated into all FT cases and 147 of the 269 MT, but no PT. At hospitalization, the SRA index exceeded 30 in 276 patients. PT was observed in 274 cases, and MT an... Pathology International journals http://www.medworm.com/rss/comments.php?id=4755826 Tue, 26 Apr 2011 23:00:00 +0100 4755826 http://www.medworm.com/index.php?rid=4755825&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02669.x Peritoneal seeding (PS) of hepatocellular carcinoma (HCC) is uncommon, and the clinicopathological features are poorly understood. A total of 181 autopsy cases of HCC, including 171 cases with detailed clinical information, was investigated for PS and evaluated. PS was identified in 17 cases (9.4%), and was locally (70.6%) or entirely (29.4%) distributed in the peritoneal cavity, involving the diaphragm (76.5%), omentum (47.1%), or alimentary tract serosa (47.1%). Compared with primary HCC, PS showed similar or slightly undifferentiated features (88.2%) and exhibited more differentiated features (11.8%). In 15 cases (88.2%) of HCC with PS, primary HCC showed membranous β‐catenin immunoreactivity. However, in five cases (33.3%), respective PS lost this immunoreactivity. PS was significan... Pathology International journals http://www.medworm.com/rss/comments.php?id=4755825 Tue, 26 Apr 2011 23:00:00 +0100 4755825 http://www.medworm.com/index.php?rid=4727995&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02652.x Pulmonary capillary hemangiomatosis (PCH) is a rare cause of pulmonary hypertension. It is characterized capillary proliferation within the alveolar septa. Here, we report a case of PCH with extensive pulmonary fibrosis. A 52‐year‐old man with a clinical diagnosis of non‐specific interstitial pneumonia died of respiratory failure with severe pulmonary hypertension. Autopsy revealed pronounced right ventricle hypertrophy and pulmonary fibrosis. Consistent with clinical diagnosis, histological examination revealed diffuse pulmonary fibrosis, in addition, it also disclosed marked capillary proliferation within the alveolar septa as well as the fibrotic pulmonary stroma, suggesting the presence of PCH. Hemosiderin‐laden macrophages had accumulated in the capillary proliferative area, a... Pathology International journals http://www.medworm.com/rss/comments.php?id=4727995 Wed, 20 Apr 2011 05:46:24 +0100 4727995 http://www.medworm.com/index.php?rid=4727994&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02665.x Intrahepatic cholangiocarcinoma (ICC) is reported to develop in non‐biliary chronic advanced liver diseases (CALD). Herein, we characterize the pathological features of ICC arising in CALD in comparison with those in non‐CALD livers. Of 471 surgically resected cases of ICC in Kanazawa, Japan and Seoul, Korea, 53 were associated with CALD (group A), while the remaining 418 arose in otherwiswe normal livers (group B). When ICC were classified into bile duct type, bile ductular type, variants, and intraductal papillary neoplasm of the bile duct (IPNB), the whole spectrum of subtypes were found in group A; the majority of ICC belonged to the bile duct type in both groups. In group A, bile ductular type was rather frequent (22.6%) compared with group B (8.4%). IPNB was more frequent in grou... Pathology International journals http://www.medworm.com/rss/comments.php?id=4727994 Wed, 20 Apr 2011 05:46:21 +0100 4727994 http://www.medworm.com/index.php?rid=4688723&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02655.x In conclusion, this case report further supports the notion of germinal center helper T cell origin of neoplastic clear cells in AITL. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4688723 Thu, 31 Mar 2011 23:00:00 +0100 4688723 http://www.medworm.com/index.php?rid=4660552&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02656.x Peripheral T‐cell lymphoma (PTCL) with a follicular growth pattern is very rare. Herein, a case of follicular variant of PTCL in a 50‐year‐old man who complained of tonsillar and generalized lymph node swelling is reported. The resected tonsil revealed a vague nodular growth pattern of atypical cells, medium to large in size, with abundant pale cytoplasm. The lymphoma cells were CD3+ CD4+ CD5+ CD8‐ CD10+ CD56‐ CD57‐ BCL6+ PD‐1+ CXCL13+ and were associated with a meshwork of CD21+ follicular dendritic cells. Molecular studies revealed clonal rearrangement of the T‐cell receptor gamma chain gene but not of the immunoglobulin gene. Cytogenetic analysis disclosed a complex abnormality in 18 of 20 cells with the exclusion of t(5; 9). These findings suggest that the present case ... Pathology International journals http://www.medworm.com/rss/comments.php?id=4660552 Thu, 31 Mar 2011 22:52:54 +0100 4660552 http://www.medworm.com/index.php?rid=4618255&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02660.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4618255 Tue, 22 Mar 2011 20:53:54 +0100 4618255 http://www.medworm.com/index.php?rid=4618254&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02648.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4618254 Tue, 22 Mar 2011 20:53:53 +0100 4618254 http://www.medworm.com/index.php?rid=4602681&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02650.x In conclusion, LAT 1 expression may be linked with cell proliferation and prognosis of gastric carcinomas, and offers a potential target for future anticancer therapy by inhibitors. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4602681 Thu, 17 Mar 2011 00:00:00 +0100 4602681 http://www.medworm.com/index.php?rid=4597307&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02653.x We describe a novel cystic renal tumor consisting of benign epithelial and malignant stromal components in a 56‐year‐old woman who was admitted to hospital with macroscopic hematuria. Enhanced computed tomography revealed a multilocular 3.4 × 2.7‐cm tumor in the center of the left kidney. After total left nephrectomy, the excised tumor appeared extensively cystic with a well defined border on the cut surface. Histologically, the tumor was composed of biphasic a benign epithelial lining on tubules or cysts with a typically hobnailed appearance, and anaplastic sarcomatous stroma with frequent mitosis. Periepithelial cuffing of the sarcoma cells was evident without an epithelial‐stromal transition. Carcinomatous nests, blastemic elements, ovarian‐like stroma or differentiated mesen... Pathology International journals http://www.medworm.com/rss/comments.php?id=4597307 Tue, 15 Mar 2011 00:00:00 +0100 4597307 http://www.medworm.com/index.php?rid=4562823&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02649.x Within classical extracellular matrix (ECM) proteins, there are a unique group of proteins that should be regarded as a distinct functional group of molecules. Matricellular proteins including osteopontin (OPN) and tenascin‐c (TN‐C) are highly expressed at the pathological foci of various inflammatory diseases. Unlike classical ECM proteins, these are soluble proteins and induce cell motility and persistent inflammation rather than providing a scaffold for stable cell adhesion. Osteopontin is a pleiotropic cytokine expressed by various cells. Two forms of OPN are present. A secreted form of OPN (sOPN) is involved in generation of T helper type 1 (Th1) and Th17 cells that are pathogenic T cells for various autoimmune diseases. An intracellular form of OPN (iOPN) is a critical regulator ... Pathology International journals http://www.medworm.com/rss/comments.php?id=4562823 Tue, 08 Mar 2011 00:00:00 +0100 4562823 http://www.medworm.com/index.php?rid=4562822&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02654.x Multicystic mesothelioma is a well recognized but rare serosal tumor which mainly arises from the peritoneum in women and is considered as a benign lesion. This is the second case report of pericardial multicystic mesothelioma, which took a fatal clinical course. A 63‐year‐old man presented with pitting edema, shortness of breath, and hoarseness. Radiological investigations revealed solid and cystic tumor of the pericardium which was continuously extending into the mediastinum and the liver. Pericardial biopsy showed micro‐cystic tumor lined by single layer of mesothelial cells without atypia, and the diagnosis was multicystic mesothelioma. Curative surgery could not be performed, and three years and four months later, the patient died because of the direct compression of the heart b... Pathology International journals http://www.medworm.com/rss/comments.php?id=4562822 Tue, 08 Mar 2011 00:00:00 +0100 4562822 http://www.medworm.com/index.php?rid=4562821&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02657.x Within the gastrointestinal tract, osseous metaplasia is an extremely rare phenomenon. It has only recently been described within a traditional serrated adenoma. Serrated colorectal carcinoma is the end point of the serrated neoplasia pathway. Left sided lesions typically arise from traditional serrated adenomas and represent only 8% of colorectal carcinomas. Herein reported is a case of colorectal adenocarcinoma arising from a traditional serrated adenoma with the rare occurrence of osseous metaplasia within the adenoma. The significance of the finding is discussed. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4562821 Tue, 08 Mar 2011 00:00:00 +0100 4562821 http://www.medworm.com/index.php?rid=4546496&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02647.x In conclusion, profibrogenic mesenchymal cells play an important role in the development of intestinal fibrosis in this chronic DSS‐induced colitis model. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4546496 Thu, 03 Mar 2011 00:00:00 +0100 4546496 http://www.medworm.com/index.php?rid=4602680&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02651.x Pentraxin 3 (PTX3) is the first identified long pentraxin, and it is rapidly produced and released by several cell types in response to proinflammatory signals. The aim of this study was to investigate the behavior of neutrophils to produce PTX3 protein in response to proinflammatory cytokine IL‐8 in vitro, as well as identify the expression pattern of PTX3 in human ulcerative colitis lesions.Pentraxin 3 protein was found to be present following release upon IL‐8 stimulation in cultured neutrophils together with lactoferrin+‐specific granules localized in neutrophil extracellular traps (NETs) formed by extruded DNA. Neutrophils in colonic mucosal tissue of patients with ulcerative colitis were the main cellular source of PTX3 protein, the expression of which is correlated well with t... Pathology International journals http://www.medworm.com/rss/comments.php?id=4602680 Tue, 01 Mar 2011 00:00:00 +0100 4602680 http://www.medworm.com/index.php?rid=4597306&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02645.x In conclusion, the present study provided additional evidence that high blood pressure is associated with prostate cancer risk. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4597306 Tue, 01 Mar 2011 00:00:00 +0100 4597306 http://www.medworm.com/index.php?rid=4585080&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02662.x This report concerns a unique case of a composite lymphoma composed of T‐lymphoblastic leukemia/lymphoma (T‐LBL) and diffuse large B‐cell lymphoma (DLBCL) in a 72‐year‐old woman with generalized lymphadenopathy, splenomegaly and ascites. Laboratory findings showed increased lactate dehydrogenase and soluble interleukin‐2 receptor. The biopsy specimen showed replacement of the normal architecture of the lymph nodes by a tumor containing a dual cell population composed of large lymphocytes and medium‐sized lymphocytes. Sheets of large lymphocytes often were punctuated by clusters of medium‐sized lymphocytes. Flow cytometry and immunohistochemical analysis showed a composite lymphoma with both T‐LBL and DLBCL. The T‐LBL expressed CD1a, CD3, CD4, CD8, and terminal deoxynucl... Pathology International journals http://www.medworm.com/rss/comments.php?id=4585080 Tue, 01 Mar 2011 00:00:00 +0100 4585080 http://www.medworm.com/index.php?rid=4567716&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02661.x It is about 100 years since the publication of the original description of the disorder now termed as Hashimoto's thyroiditis (HT) or Hashimoto's disease. Hashimoto's thyroiditis has been commonly considered as a well‐defined clinicopathological entity, characterized by the presence of goiter and serum thyroid autoantibodies. Very recently, new studies have reported that there is a unique subtype of HT, termed as immunoglobulin (Ig)G4 thyroiditis, which is characterized by lymphoplasmacytic infiltration, fibrosis, increased IgG4‐positive plasma cell in the thyroid and high IgG4 level in the serum. Furthermore, from a clinical aspect, IgG4 thyroiditis presents significantly different characteristics from non‐IgG4 thyroiditis, with IgG4 thyroiditis being more closely associated with ... Pathology International journals http://www.medworm.com/rss/comments.php?id=4567716 Tue, 01 Mar 2011 00:00:00 +0100 4567716 http://www.medworm.com/index.php?rid=4562820&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02659.x We present a case study of endobronchial mixed papilloma with immunohistochemical and etiological investigations. A 49‐year‐old male with a smoking history complained of hemoptysis, presented with a lung mass closely adjacent to large vessels in the computed tomography findings, and underwent lobectomy. The 3.0‐cm sized polypoid tumor was histologically diagnosed as endobronchial mixed papilloma. Immunohistochemically, intracellular mucin was positive for MUC5AC, which is expressed in tracheobronchial goblet cells. CAM5.2 and CK19 were diffusely positive, indicating that the tumor originated from the columnar epithelium by squamous metaplasia. CEA and CA19‐9 were focally positive. A human papillomavirus (HPV) investigation with in situ hybridization using a wide spectrum probe and ... Pathology International journals http://www.medworm.com/rss/comments.php?id=4562820 Tue, 01 Mar 2011 00:00:00 +0100 4562820 http://www.medworm.com/index.php?rid=4556389&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02646.x KAI1 COOH‐terminal interacting tetraspanin (KITENIN) contributes to tumor invasion and metastasis in various cancers. The aim of current study was to evaluate whether KITENIN affects tumor cell invasion and prognosis in human colorectal cancers. We investigated the biologic role of KITENIN on tumor cell invasion by using small interfering RNA in Caco2, DLD1, and SW480. We evaluated the expression of KITENIN and activator protein‐1 (AP‐1) target genes in human colorectal cancer tissues. The tumor cell invasion was decreased by knockdown of KITENIN in three tested cell lines. The mRNA expression of cyclin D1 and COX‐2 was decreased in KITENIN knockdown Caco2 and the mRNA expression of MMP‐3 and COX‐2 was decreased in KITENIN knockdown DLD1 and SW480. The extracellular‐signal pr... Pathology International journals http://www.medworm.com/rss/comments.php?id=4556389 Tue, 01 Mar 2011 00:00:00 +0100 4556389 http://www.medworm.com/index.php?rid=4546495&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02658.x In conclusion, heightened awareness of the histomorphologic spectrum, appropriate IHC investigation, and informed appraisal thereof, are critical to the diagnosis of AKS with an undifferentiated phenotype, and the avoidance of IHC pitfalls, such as those caused by under‐recognition and misinterpretation of bystander SLCs in AKS. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4546495 Tue, 01 Mar 2011 00:00:00 +0100 4546495 http://www.medworm.com/index.php?rid=4533863&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2010.02636.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4533863 Tue, 01 Mar 2011 00:00:00 +0100 4533863 http://www.medworm.com/index.php?rid=4533862&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2010.02643.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4533862 Tue, 01 Mar 2011 00:00:00 +0100 4533862 http://www.medworm.com/index.php?rid=4533861&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2010.02622.x (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4533861 Tue, 01 Mar 2011 00:00:00 +0100 4533861 http://www.medworm.com/index.php?rid=4533860&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2011.02644.x Immunoglobulin binding protein 1 (IGBP‐1) was initially identified as a signal transduction molecule coprecipitating with MB1 (Igα) of the B cell antigen receptor (BCR) complex and was later found to be broadly expressed. Immunoglobulin binding protein 1 has been characterized as an associated and regulatory component of the catalytic subunits of protein phosphatase 2A (PP2A), which is the most abundant phosphatase and plays important roles in cell growth and cell cycle control. The aim of this study was to investigate the expressional characteristics of IGBP‐1 and PP2Ac during pulmonary adenocarcinogenesis. The positivity rate of IGBP‐1 increased during the course of sequential progression from non‐invasive carcinoma (8/30, 26.7%) to invasive adenocarcinoma (37/46, 80.4%) among c... Pathology International journals http://www.medworm.com/rss/comments.php?id=4533860 Tue, 01 Mar 2011 00:00:00 +0100 4533860 http://www.medworm.com/index.php?rid=4461647&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2010.02641.x We describe one such case in a 49‐year‐old Japanese man who had shown an elevated serum concentration of granulocyte colony‐stimulating factor (GCSF) and leukocytosis without a shift to the left. Histologically, the tumor formed a teratomatous cyst whose wall contained benign epithelial components, well‐differentiated tubular and mucinous adenocarcinoma, and poorly‐differentiated pleomorphic carcinoma. Immunohistochemically, both the well differentiated adenocarcinoma and poorly differentiated pleomorphic carcinoma expressed GCSF. Immunohistochemistry and molecular analysis revealed that both components also produced interleukin 6 receptor (IL6R). We diagnosed this tumor as a GCSF‐ and IL6R‐producing mediastinal mature cystic teratoma with somatic‐type malignancy. The tumor... Pathology International journals http://www.medworm.com/rss/comments.php?id=4461647 Tue, 01 Feb 2011 00:00:00 +0100 4461647 http://www.medworm.com/index.php?rid=4452308&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2010.02640.x We report an undescribed case of primary retroperitoneal dysgerminoma presenting as an adrenal tumor in a 17‐year‐old girl. Surgery was performed on a 10 × 9.5 cm sized adrenal gland tumor and the resected tumor showed unequivocal histological features of dysgerminoma. The diagnosis was confirmed by the tumor's germ cell immunophenotype. Postoperative ultrasonography, CT and PET over a 6‐month period revealed no evidence of ovarian lesion. The patient is stable, but with a suspicious residual tumor after adjuvant chemotherapy. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4452308 Tue, 01 Feb 2011 00:00:00 +0100 4452308 http://www.medworm.com/index.php?rid=4402182&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2010.02637.x In conclusion, this bronchial reconstruction study demonstrated marked morphological differences in the mechanisms of airway obliteration between two major morphologic subtypes of BO. (Source: Pathology International) Pathology International journals http://www.medworm.com/rss/comments.php?id=4402182 Thu, 27 Jan 2011 18:52:30 +0100 4402182 http://www.medworm.com/index.php?rid=4402183&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2010.02642.x Collision tumors of the vulva are uncommon. Mammary‐type myofibroblastoma is a rare benign tumor arising at extramammary sites with morphological and immunophenotypic features similar to the breast counterpart. Eccrine adenocarcinoma of the vulva is rare. The authors report here a true collision tumor containing a mammary‐type myofibroblastoma with intermingling components of eccrine adenocarcinoma occurring in the vulva. An 80‐year‐old woman presented with a subcutaneous nodule in the vulva. The tumor was well circumscribed but unencapsulated. The mammary‐type myofibroblastoma and the adenocarcinoma measured 4 cm × 3.5 cm × 1.0 cm and 1.5 cm × 1.2 cm × 0.8 cm, respectively. In the overlying superficial dermis there was an eccrine adenocarcinoma. It was composed o... Pathology International journals http://www.medworm.com/rss/comments.php?id=4402183 Wed, 26 Jan 2011 00:00:00 +0100 4402183 http://www.medworm.com/index.php?rid=4391063&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2010.02639.x In this study, during the course of infection with srr7, small spongiotic lesions became apparent at 2 days post‐inoculation (pi), they spread out to form spongiform encephalopathy by 8 to 10 days pi. We recently reported that the initial expressions of viral antigens in the brain are detected in the infiltrating monocyte lineage and in ependymal cells. Here, we demonstrate that the next viral spread was observed in glial fibrillary acidic protein‐positive cells or nestin‐positive progenitor cells which take up positions in the subventricular zone (SVZ). From this restricted site of infection in the SVZ, a large area of gliosis extended deep into the brain parenchyma where no viral antigens were detected but vacuolar degeneration started at 48 h pi of the virus. The extremely s... Pathology International journals http://www.medworm.com/rss/comments.php?id=4391063 Tue, 25 Jan 2011 00:42:51 +0100 4391063 http://www.medworm.com/index.php?rid=4333892&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2010.02634.x The CD79 molecule, encoded by the CD79a and CD79b genes, is a signaling unit of the B‐cell receptor complex, which transmits signals of B‐cell activation, growth, and differentiation. They are B‐cell‐specific and expressed at most stages of B‐cell development. Although plasma cells have been believed to lack these gene products, the regulation of CD79 expression in plasma cells is still controversial. In particular, the regulation of CD79b expression remains unclear. We sought to examine CD79b expression in normal and neoplastic plasma cells by immunohistochemical analysis. Out of the 23 clinical samples and 11 cell lines of plasma cell myeloma (PCM), none of the clinical samples and only 1 of 11 cell lines expressed CD79b immunohistologically, whereas non‐neoplastic plasma cel... Pathology International journals http://www.medworm.com/rss/comments.php?id=4333892 Sat, 01 Jan 2011 00:00:00 +0100 4333892 http://www.medworm.com/index.php?rid=4328165&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2010.02633.x There has been a recent increase in the number of small clear cell renal cell carcinoma (ccRCC) cases, particularly in pT1a cases. The prognostic parameters for small ccRCC, however, are not well described. Herein, we assess the pathological parameters of pT1a patients. Various clinicopathological parameters were analyzed in 293 patients with pT1a ccRCC without pre‐operative metastasis to predict the disease‐free survival rate (DFS) and the cancer‐specific survival rate (CSS). Clinicopathological parameters included age, tumor location, Fuhrman grade, lymph‐vascular invasion (LVI), tumor necrosis, and growth pattern (expansive or infiltrative). In the univariate analysis, Fuhrman grade (grade 1 + 2 vs. 3 + 4), LVI, growth pattern, and tumor necrosis were parameters associat... Pathology International journals http://www.medworm.com/rss/comments.php?id=4328165 Sat, 01 Jan 2011 00:00:00 +0100 4328165 http://www.medworm.com/index.php?rid=4319963&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2010.02635.x We report a case of gastric adenocarcinoma, concurrently possessing choriocarcinoma and yolk sac tumor components, of a 74‐year‐old man. A hemorrhagic, 11 × 8 × 3 cm, tumor with ulceration was located in the body and pre‐pylorus of the stomach. Histological examination of the resected specimens demonstrated intermingled proliferation of three different components, namely, adenocarcinoma, choriocarcinoma and yolk sac tumor, which were immunoreactive for carcinoembryonic antigen (CEA), beta‐subunit of human chorionic gonadotropin (HCG) and alpha‐fetoprotein (AFP), respectively. Gastric cancers with germ cell tumor components are uncommon and this is the second reported case of gastric cancer with choriocarcinoma and yolk sac tumor components. (Source: Pathology Internat... Pathology International journals http://www.medworm.com/rss/comments.php?id=4319963 Sat, 01 Jan 2011 00:00:00 +0100 4319963 http://www.medworm.com/index.php?rid=4311174&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2010.02628.x Myopericytoma is a benign neoplasm consisting of cells that appear to have a distinct differentiation towards presumed perivascular myoid cells. Amongst myopericytoma, an intravascular variant appears to have been reported only rarely. A 67‐year‐old man presented with a 15‐year history of a painful, slow growing 3 × 3.5 cm sized mass in the subcutis of his right lateral thigh. Histopathological studies showed a subcutaneous mass entirely within the lumen of a vein. The tumor was composed of spindle‐shaped myoid‐appearing cells in a concentric arrangement, intimately associated with thin‐walled vascular channels. Tumor cells were diffusely positive for smooth muscle actin, focally positive for CD34, and negative for desmin and CD31. From these findings, we diagnosed this lesi... Pathology International journals http://www.medworm.com/rss/comments.php?id=4311174 Sat, 01 Jan 2011 00:00:00 +0100 4311174 http://www.medworm.com/index.php?rid=4290676&cid=s_28435_32_f&fid=28435&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1440-1827.2010.02618.x The peptidylprolyl isomerase Pin1 is over‐expressed in some human diseases including malignancies and chronic inflammatory diseases, this suggests that it contributes to the constitutive activation of certain intracellular signaling pathways that promote cell proliferation and cell invasion. Here, we investigate the possible role of Pin1 in rheumatoid arthritis (RA). Pin1 expression was immunohistochemically analyzed in synovial tissue (ST) obtained from patients with RA and osteoarthritis (OA). To investigate the correlation between Pin1 and motility and proliferation of synovial cells, Pin1 localization was immunohistochemically compared with matrix metalloproteinase (MMP)‐1, MMP‐3, and proliferating cell nuclear antigen (PCNA). Double immunofluorescent staining for Pin1 and p65 wa... Pathology International journals http://www.medworm.com/rss/comments.php?id=4290676 Tue, 28 Dec 2010 22:28:21 +0100 4290676