MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Pathology Oncology Research' source. Thu, 09 Feb 2012 00:42:20 +0100 http://www.medworm.com/index.php?rid=5646434&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22286960%26dopt%3DAbstract Authors: Ozturk OG PMID: 22286960 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5646434 Sun, 29 Jan 2012 05:00:00 +0100 5646434 http://www.medworm.com/index.php?rid=5646436&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22286958%26dopt%3DAbstract Authors: Nagy Z, Horváth O, Kádas J, Valtinyi D, László L, Kopper B, Blaskó G Abstract Malignant tumors are often accompanied by increased risk for procoagulant activity, thrombosis and embolism. As a marker indicating such disturbancies is D-dimer, a product of fibrinolysis. In this retrospective study almost 300 patients with malignant tumors were evaluated. During LMWH treatment (as thromboprophylaxis) the highest frequency of VTE with worst prognosis occurred in pancreatic cancer (partly due to the late discovery) followed by ovarian, colonic and breast cancers. Also, increased D-dimer level correlated with progression (stages) and high mortality rate. Furthermore, D-dimer showed very similar or better prognostic activity than the clinically widely used classic tumor marke... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5646436 Sat, 28 Jan 2012 05:00:00 +0100 5646436 http://www.medworm.com/index.php?rid=5646435&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22286959%26dopt%3DAbstract This study documents the presence SV40 T/t-antigens in a proportion of osteosarcomas in Tunisian patients. The expression of these viral oncoproteins supports the hypothesis that SV40 may have a role in the pathogenesis of this tumor. PMID: 22286959 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5646435 Sat, 28 Jan 2012 05:00:00 +0100 5646435 http://www.medworm.com/index.php?rid=5646437&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22278416%26dopt%3DAbstract This study also confirms the presence of copy number variations in retinoblastoma, expecially in unilateral cases (mean 3 ±1.3) where these changes were found more frequently respect to bilateral cases (mean 1.4 ± 1.1). PMID: 22278416 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5646437 Thu, 26 Jan 2012 05:00:00 +0100 5646437 http://www.medworm.com/index.php?rid=5630704&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22270865%26dopt%3DAbstract This study confirmed increased MVD in MDS. It does not support an independent prognostic role of angiogenesis in MDS. PMID: 22270865 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5630704 Tue, 24 Jan 2012 05:00:00 +0100 5630704 http://www.medworm.com/index.php?rid=5630702&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22270867%26dopt%3DAbstract Authors: Krzeslak A, Wojcik-Krowiranda K, Forma E, Jozwiak P, Romanowicz H, Bienkiewicz A, Brys M Abstract Cancer cells have accelerated metabolism and high glucose requirements. The up-regulation of specific glucose transporters may represent a key mechanism by which malignant cells may achieve increased glucose uptake to support the high rate of glycolysis. In present study we analyzed the mRNA and protein expression of GLUT1 and GLUT3 glucose transporters by quantitative real-time polymerase chain reaction (Q-PCR) and Western blotting technique in 76 cases of endometrial carcinoma and 70 cases of breast carcinoma. SLC2A1 and SLCA2A3 mRNAs expression was found, respectively in 100% and 97.4% samples of endometrial cancers and only in 50% and 40% samples of breast cancers. In endo... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5630702 Sat, 21 Jan 2012 05:00:00 +0100 5630702 http://www.medworm.com/index.php?rid=5630703&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22270866%26dopt%3DAbstract Authors: Jin JS, Tsao TY, Sun PC, Yu CP, Tzao C Abstract We studied the effects of suberoylanilide hydroxamic acid (SAHA), a histone deacetylase (HDAC) inhibitor, on colon cancer. The expression of HDACs in colorectal cancer specimens and the effects of SAHA on colon cancer cells and tumors of nude mice were assessed. Treatment with SAHA (3 μm) for 72 h induced downregulation of different subtypes of HDAC proteins and also induced acetylation of histone 3 and histone 4. SAHA significantly inhibited the expression of the oncogenic protein c-myc and also increased the expression of the p53 and Rb proteins. The immunohistochemical staining of HDACs, including HDAC1, HDAC2, HDAC3, and HDAC4, was significantly increased in colorectal adenocarcinoma specimens compared to healthy contr... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5630703 Fri, 20 Jan 2012 05:00:00 +0100 5630703 http://www.medworm.com/index.php?rid=5611894&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22246793%26dopt%3DAbstract Authors: Katz S, Balogh P, Nagy N, Kiss AL Abstract Intraperitoneal injection of Freund's adjuvant induces acute peritonitis. By the time of the Freund's adjuvant treatment the flat, simple squamous epithelial cells became rounded, cuboidal shaped, many of them have lost their connection with the neighbouring cells and detached from the basement membrane. The macrophage markers' (ED1, OX43 and CD68) expression also increased in the mesothelial cells and more mesothelin and anti-ED1 double-labelled cells were found freely present close to the surface. The cytokeratin expression of the mesothelial cells has gradually decreased. At the 5th day of the inflammation practically there was no cytokeratin labelling present in the mesothelial cells and the mesothelin expression has significa... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5611894 Sat, 14 Jan 2012 05:00:00 +0100 5611894 http://www.medworm.com/index.php?rid=5611893&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22246794%26dopt%3DAbstract Authors: Wang L, Yang M, Shan L, Qi L, Chai C, Zhou Q, Yao K, Wu H, Sun W Abstract We aimed to investigate the expression of SPARC (secreted protein, acidic and rich in cysteine) in gastric cancer and its relationship with tumor angiogenesis and cancer cells proliferation. Protein expression of SPARC, VEGF, CD34 and Ki-67 in 80 cases of gastric cancer and 30 cases of normal gastric tissue was evaluated by immunohistochemistry. CD34 staining was used as an indicator of microvessel density (MVD). Ki-67 labeling Index (LI) indicated cancer cells proliferation. Statistical analysis was used to investigate its relationship with clinical characteristics, tumor angiogenesis and cancer cells proliferation. SPARC expression was mainly in the stromal cells surrounding the gastric cancer cell... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5611893 Fri, 13 Jan 2012 05:00:00 +0100 5611893 http://www.medworm.com/index.php?rid=5587042&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22234624%26dopt%3DAbstract Authors: Andjelic BM, Mihaljevic BS, Jakovic LR Abstract Advanced age is considered an unfavourable prognostic factor for Hodgkin's lymphoma (HL). The optimal treatment for these patients is not yet defined, especially for the advanced stages. We analysed the outcome and prognostic relevance of patient and disease characteristics in 46 advanced stage HL patients who were older than 45 years, treated with ABVD. Elderly patients (>60 year) had a significantly higher rate of comorbidities (p < 0.05). The complete remission rate was significantly lower in elderly patients and in patients with an IPS ≥3 (p < 0.05, p < 0.05, respectively). Elderly patients had significantly shorter event-free survival (p < 0.01) and overall survival (p < 0.01) co... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5587042 Wed, 11 Jan 2012 05:00:00 +0100 5587042 http://www.medworm.com/index.php?rid=5587043&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22228187%26dopt%3DAbstract Authors: Ebrahimkhani S, Asgharian AM, Nourinaier B, Ebrahimkhani K, Vali N, Abbasi F, Zali MR Abstract Colorectal cancer is a major cause of morbidity and mortality both globally and in Iran. The aim of this study was to determine the association between genetic polymorphisms of glutathione S-transferases P1, M1 and T1 (GSTP1, M1, T1) and susceptibility to colorectal cancer (CRC). Genotyping of GSTP1, GSTM1 and GSTT1 was performed by the use of pyrosequencing. One hundred cases and healthy controls were enrolled into this study. Mean GSTT1 polymorphism type was significantly (P < 0.01) higher in cases as compared to controls (P < 0.0001: OR, 2.43: 95% CI, 1.47-4). On the other hand there is no significant association between GSTM1, GSTP1 and colorectal cancer. GSTs m... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5587043 Sun, 08 Jan 2012 05:00:00 +0100 5587043 http://www.medworm.com/index.php?rid=5571703&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215309%26dopt%3DAbstract Authors: Li Z, Liao Q, Wu Y, Liao M, Hao Y, Zhang S, Song S, Li B, Zhang YD Abstract To investigate the clinicopathological and prognostic value of a disintegrin and metalloprotease 8 (ADAM8) in osteosarcoma. ADAM8 expression in osteosarcoma tissues was examined by immunohistochemistry in 69 patients. ADAM8 was positively expressed in 61 of 69 (88.4%) osteosarcoma specimens with cytoplasmic staining, and also increased in the specimens with recurrence (P = 0.008) and metastasis (P = 0.002). Patients with strong ADAM8 expression had significantly poorer overall survival (OS) and disease-free survival (DFS) (both P < 0.001) when compared with the patients with the weak expression of ADAM8. On multivariate analysis, ADAM8 expression was found to be an independent progno... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5571703 Thu, 05 Jan 2012 05:00:00 +0100 5571703 http://www.medworm.com/index.php?rid=5571702&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22215310%26dopt%3DAbstract Authors: Carmignani L, Picozzi S, Casellato S, Bozzini G, Marenghi C, Macchi A, Lunelli L, Rubino B, Clemente C Abstract The aim of our study, beyond validating a method of collecting and storing biological samples from patients with prostate cancer, was to validate an innovative biopsy method for the creation of a biobank of prostatic frozen tissues. Patients referred to our hospital between November 2008 and March 2010 to undergo radical prostatectomy were invited to participate in the study. Each patient's data were stored in two databases (personal information and clinical database) while samples of urine, blood and its derivatives, fresh material and formalin-processed tissue were stored in a correlated biobank. The proposed method for collecting fresh material was to take sam... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5571702 Wed, 04 Jan 2012 05:00:00 +0100 5571702 http://www.medworm.com/index.php?rid=5556739&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22205577%26dopt%3DAbstract Authors: Chiang Y, Zhou X, Wang Z, Song Y, Liu Z, Zhao F, Zhu J, Xu H Abstract MicroRNAs (miRNAs) are small, non-coding RNAs of endogenous origin. Accumulating studies have shown aberrant miRNA expression plays an important role in many tumor types. miR-192 and -215, which have the same "seed region", have not been comprehensively investigated using a large number of cases in gastric cancer. The total RNA was extracted from 118 gastric cancer tissues and three gastric cancer cell lines as well as matched non-tumor adjacent tissues (NATs). After polyadenylation and reverse transcription, expression levels of miR-192 and -215 were determined by real-time PCR and calculation using the 2(-∆∆CT) method for evaluation of the association between miR-192, and -215 expression levels and... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5556739 Thu, 29 Dec 2011 05:00:00 +0100 5556739 http://www.medworm.com/index.php?rid=5556740&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22198862%26dopt%3DAbstract This study was based on surgically removed parathyroid tissues, gene expression analysis was performed both at gene and protein level. First, mRNA isolation was performed from deep-frozen tissue samples, and further apoptosis pathway-specific cDNA macroarray analysis was carried out. The results were validated with real-time PCR. Subsequently, protein expression was analyzed with immunhistochemistry on Tissue Micro Array multi-blocks derived from several paraffin-embedded samples. cDNA macroarrays revealed elevated expression of both pro-apoptotic (FAS receptor, TRAIL ligand, CASPASE8, and -4) and anti-apoptotic (cIAP1, APOLLON) genes in benign proliferative lesions compared to that in normal gland. TMA studies showed overexpression of KI67, P53, SURVIVIN and APOLLON protein and failure of... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5556740 Sat, 24 Dec 2011 05:00:00 +0100 5556740 http://www.medworm.com/index.php?rid=5542546&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22193974%26dopt%3DAbstract Authors: Tőkés AM, Szász AM, Juhász E, Schaff Z, Harsányi L, Molnár IA, Baranyai Z, Besznyák I, Zaránd A, Salamon F, Kulka J Abstract In the past few decades an enormous amount of data became known to clarify the molecular composition and architecture of tight junctions (TJs). Despite the efforts, the expression and function of several TJ genes and proteins in breast carcinoma are still not known and some of the data are contradictory. The expression of forty-four TJ associated genes was examined at mRNA level in eighteen invasive ductal breast carcinoma samples and corresponding normal breast tissues by using low density array PCR. Expressions of claudins (CLDNs) 5, 10, 16, 17, and 18, and ZO-1, ZO-2 were evaluated by immunohistochemistry as well. Using immunohistochemical... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5542546 Fri, 23 Dec 2011 05:00:00 +0100 5542546 http://www.medworm.com/index.php?rid=5521368&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22179685%26dopt%3DAbstract Authors: Helpap B, Kristiansen G, Beer M, Köllermann J, Oehler U, Pogrebniak A, Fellbaum C Abstract High upgrading rates of Gleason score 6 to 7 carcinomas between biopsy and radical prostatectomy specimens may be produced by change of fused glands of pattern 3 to pattern 4. Therefore, inter-observer reproducibility of fused and non-fused glands in biopsy specimens was analysed. Images of H&E stained slides of glands of carcinomas with Gleason score 6 and 7 (3 + 4) with and without glandular fusions with different lens magnification were analysed by 4 specialized genitourinary pathologists and 3 non-specialized pathologists. The definition of glandular fusion was a complete lack of any stromal fibres between a minimum of two glands and only one line of nuclei within the ar... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5521368 Sat, 17 Dec 2011 05:00:00 +0100 5521368 http://www.medworm.com/index.php?rid=5521369&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22173612%26dopt%3DAbstract Authors: Cui Q, Li D, Zhang J, Wang X, Liu S, Wang L, Zhang P, Zhou J, Liu C, Jiang W, Zeng Y Abstract To investigate the effect of preoperative induction chemotherapy on treatment of recurrent liposarcoma. 21 patients with recurrent liposarcoma received the treatment of preoperative intra-arterial chemotherapy and surgical resection. Intra-arterial chemotherapy was given by subcutaneous implantable drug delivery system with infusion of cisplatin and doxorubicin followed by caffeine. After treatment, patients were followed up for 39 months. The liposarcoma changes in CT imaging were observed in 18 cases and there were 15 cases with medium or severe pathological changes caused by chemotherapy. At the end of the postoperative follow-up of 39 months, liposarcoma reoccurred locally i... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5521369 Fri, 16 Dec 2011 05:00:00 +0100 5521369 http://www.medworm.com/index.php?rid=5502295&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22161024%26dopt%3DAbstract Authors: Fehér LZ, Pocsay G, Krenács L, Zvara A, Bagdi E, Pocsay R, Lukács G, Győry F, Gazdag A, Tarkó E, Puskás LG Abstract Papillary thyroid carcinoma (PTC) is the most common well-differentiated thyroid cancer. Although the great majority of the cases exhibit an indolent clinical course, some of them develop local invasion with distant metastasis, and a few cases transform into undifferentiated/anaplastic thyroid carcinoma with a rapidly lethal course. To identify gene copy number alterations predictive of metastatic potential or aggressive transformation, array-based comparative genomic hybridization (CGH-array) was performed in 43 PTC cases. Formalin-fixed and paraffin-embedded samples from primary tumours of 16 cases without metastasis, 14 cases with only regional lymph... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5502295 Sun, 11 Dec 2011 05:00:00 +0100 5502295 http://www.medworm.com/index.php?rid=5502294&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22161134%26dopt%3DAbstract Authors: Rácz G, Csenki Z, Kovács R, Hegyi A, Baska F, Sujbert L, Zsákovics I, Kis R, Gustafson R, Urbányi B, Szende B Abstract Disinfection of raw water is essential to the production of drinking water. However, by-products of disinfection may exert toxic effects. The potential toxic effects of two of these compounds, 4-ethylbenzaldehyde (EBA) and 2,4-difluoroaniline (DFA) were investigated using the zebrafish (Danio rerio) model. The two compounds, dissolved, were introduced in duplicate aquariums containing zebrafish in two different concentrations based on LC50 values. The aquarium water containing EBA or DFA was changed every 96 h throughout the 3 months of treatment. Behavior of the fish in each replicate was inspected twice daily. In course of treatment with both conce... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5502294 Sun, 11 Dec 2011 05:00:00 +0100 5502294 http://www.medworm.com/index.php?rid=5502292&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22161225%26dopt%3DAbstract Authors: Koutsaki M, Zaravinos A, Spandidos DA Abstract Ovarian cancer (OC) is a heterogeneous disease, including a broad spectrum of histological subtypes and demonstrating diverse biological behavior. Epithelial-derived ovarian malignant tumours constitute the predominant and most lethal form of the disease. Age, genetic predisposition, gynecological and reproductive factors and environmental factors are the main risk factors that increase the risk for acquiring OC. Vaginal examination, ultrasonography and measurement of blood serum levels of tumour markers, especially CA125 constitute the first-line screening modalities for OC, whereas second-line testing involves more accurate imaging techniques such as color Doppler ultrasound of the lesion or/and a CT scan. Sex steroid hormon... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5502292 Fri, 09 Dec 2011 05:00:00 +0100 5502292 http://www.medworm.com/index.php?rid=5502293&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D22161157%26dopt%3DAbstract Authors: Hasby EA Abstract Investigate FasL and survivin expression in a series of primary ovarian surface epithelial tumors, correlate their expression with each other, and characterize the presence of CD3+ T-lymphocytes in studied tumors and determine whether their presence correlates with FasL or survivin expression in malignant cases. FasL and survivin expression was assessed in 54 ovarian epithelial tumors. The results were compared between different tumor types and grades. Correlation between both markers' expression in all studied tumors was done. Either marker's expression was compared to the mean CD3+ T-lymphocytes per HPF in the studied malignant tumors. Either FasL or survivin expression was significantly higher in malignant versus benign ovarian epithelial tumors (p &... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5502293 Thu, 08 Dec 2011 05:00:00 +0100 5502293 http://www.medworm.com/index.php?rid=5288124&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21964914%26dopt%3DAbstract Authors: Kaira K, Okumura T, Nakagawa K, Ohde Y, Takahashi T, Murakami H, Naito T, Endo M, Kondo H, Nakajima T, Yamamoto N Abstract MUC1 expression has been described as a predictor for tumor progression and worsening of prognosis in various human neoplasms. However, little is known about the role of MUC1 expression in pulmonary metastatic tumors. The aim of this study is to examine the clinicopathological significance of MUC1 expression in pulmonary metastatic tumors (PMT). One hundred forty-seven patients with PMT who underwent (18)F-FDG PET before metastasectomy were included in this study. Tumor sections were stained by immunohistochemistry for MUC1, glucose transporter 1 (Glut1), hypoxia-inducible-1α (HIF-1α) and vascular endothelial growth factor (VEGF). (18)F-FDG uptake an... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5288124 Sun, 02 Oct 2011 04:00:00 +0100 5288124 http://www.medworm.com/index.php?rid=5270227&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21953323%26dopt%3DAbstract Authors: Gasparinho MG, Morgado S, Fonseca R, Chaves P PMID: 21953323 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5270227 Wed, 28 Sep 2011 04:00:00 +0100 5270227 http://www.medworm.com/index.php?rid=5270226&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21953324%26dopt%3DAbstract Authors: Mahta A, Qu Y, Nastic D, Sundstrom M, Kim RY, Saria M, Santagata S, Kesari S Abstract Herein, we present an adult case of medulloblastoma who received chemotherapy, radiation therapy and stem cell transplantation, and underwent multiple surgical resections for what were thought to be recurrences; however pathology confirmed a diagnosis of relapsing tumefactive lesions. This phenomenon seems to be a consequence of stem cell transplantation rather than a simple radiation treatment effect. PMID: 21953324 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5270226 Wed, 28 Sep 2011 04:00:00 +0100 5270226 http://www.medworm.com/index.php?rid=5270228&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21938482%26dopt%3DAbstract Authors: Jia Y, Liu M, Huang W, Wang Z, He Y, Wu J, Ren S, Ju Y, Geng R, Li Z Abstract To investigate the effects of recombinant human endostatin Endostar on metastasis and angiogenesis and lymphangiogenesis of colorectal cancer cells in a mouse xenograft model. Colon cancer cells SW620 were injected subcutaneously into the left hind flank of nude mice to establish mouse xenograft models. The mice were treated with normal saline or Endostar subcutaneously every other day. The growth and lymph node metastasis of tumor cells, angiogenesis and lymphangiogenesis in tumor tissue were detected. Apoptosis and cell cycle distribution were studied by flow cytometry. The expression of VEGF-A, -C, or -D in SW620 cells was determined by immunoblotting assays. Endostar inhibited tumor growth an... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5270228 Thu, 22 Sep 2011 04:00:00 +0100 5270228 http://www.medworm.com/index.php?rid=5236353&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21927980%26dopt%3DAbstract Authors: Wang CM, Fu H, Zhao GF, Wang J, Shi YQ PMID: 21927980 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5236353 Sat, 17 Sep 2011 04:00:00 +0100 5236353 http://www.medworm.com/index.php?rid=5223826&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21910091%26dopt%3DAbstract Authors: Ulamec M, Džombeta T, Cupić H, Leniček T, Tomas D, Krušlin B Abstract Retraction clefting is known to appear in various types of tumors, but it has only recently been recognized as a specific histological phenomenon. Previously, it was considered merely a laboratory procedure artifact, but lately, there have been some assumptions that peritumoral retractions actually represent lymphatic spaces. In our study, we analyzed neoplastic glands in 52 specimens of prostatic adenocarcinoma. Immunohistochemical analysis was performed using D2-40 antibody, to highlight lymphatic endothelium and thereby differentiate actual lymph vessels or lymphovascular invasion from periacinar retractions. Our results showed that the number of lymph vessels was significantly lower in tumorous t... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5223826 Tue, 13 Sep 2011 04:00:00 +0100 5223826 http://www.medworm.com/index.php?rid=5223825&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21912905%26dopt%3DAbstract Authors: Valcz G, Sipos F, Krenács T, Molnár J, Patai AV, Leiszter K, Tóth K, Wichmann B, Molnár B, Tulassay Z Abstract Our aim was to examine cell transition events by detecting the frequency of intrapithelial α-smooth muscle actin (SMA)(+)/cytokeratin (CK)(+) cells during colorectal adenoma-carcinoma sequence, in relation to E-cadherin expression. Our further aim was to determine the proliferative activity of intraepithelial α-SMA(+) cells. Histologically healthy, adenoma, and colorectal cancer (CRC) biopsy samples were taken during routine colonoscopy and were included into tissue microarrays (TMAs). Slides immunostained for Ki-67, α-SMA, E-cadherin and pan-cytokeratin were digitalized and analyzed by using a digital microscope software. The proportion of α-SMA(+)/CK(+) ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5223825 Tue, 13 Sep 2011 04:00:00 +0100 5223825 http://www.medworm.com/index.php?rid=5223823&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21912906%26dopt%3DAbstract This study demonstrated the origin of and the biological mechanisms responsible for periacinar retraction clefting in prostatic carcinoma. PMID: 21912906 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5223823 Tue, 13 Sep 2011 04:00:00 +0100 5223823 http://www.medworm.com/index.php?rid=5223835&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21910036%26dopt%3DAbstract In conclusion, galectin-3 is expressed in PDAC tissues suggesting a role in tumor development; however, no relationship between expression and clinical findings could be established. PMID: 21910036 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5223835 Mon, 12 Sep 2011 04:00:00 +0100 5223835 http://www.medworm.com/index.php?rid=5223839&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21909684%26dopt%3DAbstract Authors: Liao M, Tong P, Zhao J, Zhang Y, Li Z, Wang J, Feng X, Hu M, Pan Y Abstract Matrix metalloproteinase-1 (MMP-1) is proposed to be involved in both tumor cell invasion and metastasis. MMP-1 proteolytically activates protease activated receptor-1 (PAR-1), which also plays an important role in tumor development and progression. However, it is currently unknown whether MMP-1 activation of PAR-1 has relevance to the progression of hepatocellular carcinoma (HCC). To address this problem, we investigate the clinicopathological and prognostic value of MMP-1/PAR-1 signaling axis in HCC. Immunohistochemistry assay was used to determine the expression of MMP-1 and PAR-1 proteins in normal and HCC tissues. The correlations of MMP-1 and PAR-1 expression with clinicopathological paramete... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5223839 Sat, 10 Sep 2011 04:00:00 +0100 5223839 http://www.medworm.com/index.php?rid=5223837&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21909685%26dopt%3DAbstract Authors: Singh A, Mishra AK, Ylaya K, Hewitt SM, Sharma KC, Saxena S Abstract The aim of this study is to identify immunohistochemical (IHC) markers that can reliably separate schwannoma (SCHW) and fibroblastic meningioma (FM). We selected 106 cases of intracranial SCHW (n = 56) and FM (n = 50) and constructed a tissue microarray (TMA) of core diameter of 1.0 mm from archival formalin-fixed paraffin-embedded tissue. A TMA-IHC was performed using 14 antibodies. After IHC staining, 98 cores were found suitable for evaluation. The IHC staining was scored as 0-2+ (0, negative; 1+, weak and/or focal 2+ strong and/or diffuse positive). A discriminant analysis (DA) (Wilks'Lambda test) was performed to assess the relative importance of these biomarkers in classifying the two group... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5223837 Sat, 10 Sep 2011 04:00:00 +0100 5223837 http://www.medworm.com/index.php?rid=5223836&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21909686%26dopt%3DAbstract Authors: Gong L, Cui Z, Yu X, Wei Y, Peng J, Leng X Abstract Hexokinase II is a key enzyme in the glycolytic pathway and CD133+ human hepatoma cells possess cancer stem cell-like properties. The expression and enzyme activity of hexokinase II in CD133+ and CD133- hepatoma cells were examined. CD133 on the surface of the hepatoma BEL-7402 cells was analyzed by flow cytometry and the cells were magnetically sorted into CD133+ and CD133- groups. CD133+ cells comprised 1.04% of the total BEL-7402 cell population. Reverse transcription-polymerase chain reaction (PCR) and quantitative real-time PCR were used to assay the expression of hexokinase II mRNA in these two groups. The level of mRNA in CD133- cells was 4.35 times greater than the level in CD133+ cells. 3,6-biphosphoglucose dehyd... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5223836 Sat, 10 Sep 2011 04:00:00 +0100 5223836 http://www.medworm.com/index.php?rid=5207362&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901273%26dopt%3DAbstract Authors: Liu C Abstract The serum amyloid A (SAA) protein is an acute phase protein that is synthesized under the regulation of inflammatory cytokines during both acute and chronic inflammation. It is suggested that the SAA increases correlate with many types of carcinogenesis and neoplastic diseases. Th changes in SAA in serum could therefore indicate the progress and malignancy of the disease, as well as the host responses. The present paper reviewed the rationale of using SAA as potential cancer biomarker in clinical diagnosis, including the contribution and involvement of SAA in cancer growth and development. Then we discussed the current applications of SAA in diagnosis and tracing of different types of cancers. Finally the proteomics techniques, especially the SELDI-TOF MS to... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5207362 Thu, 08 Sep 2011 04:00:00 +0100 5207362 http://www.medworm.com/index.php?rid=5207360&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901275%26dopt%3DAbstract Authors: Rizvi MM, Alam MS, Mehdi SJ, Ali A, Batra S Abstract Cervical cancer is one of the most common malignant diseases affecting women worldwide. Studies on loss of heterozygosity have been made for PTEN gene specific microsatellite markers in malignancies like breast, ovary and lungs and the results have shown a significant association. However the role of this gene is not clearly understood in cervical cancer from Indian population. A total of 135 cervical carcinoma tissues samples were analyzed for loss of heterozygosity. DNA was isolated from the samples and their matched control specimens. Polymerase chain reaction was performed using primer specific for two intragenic markers (D10S198 & D10S192) and one marker (D10S541) in flanking region and further electrophoresed o... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5207360 Thu, 08 Sep 2011 04:00:00 +0100 5207360 http://www.medworm.com/index.php?rid=5207363&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21898071%26dopt%3DAbstract In conclusion, the decreased expression of Dicer and Drosha may play a role in down-regulation of miRNAs in breast cancer. PMID: 21898071 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5207363 Wed, 07 Sep 2011 04:00:00 +0100 5207363 http://www.medworm.com/index.php?rid=5207361&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901274%26dopt%3DAbstract The objectives of this study were: (1) to identify the characteristics of the CA125 isolated from healthy and patient women with epithelial ovarian cancer; and (2) to determine the ferning structure of this antigen. The cancer-derived CA125 antigen (cCA125) purified by gel filtration and affinity chromatography (Concanavalin A) was run on SDS-PAGE and examined using light microscopy and compared with healthy-derived CA125 antigen (hCA125). Both purified antigen cCA125 and hCA125 showed a high molecular mass (> 2,000 kDa) with high mannose glycans. The ferning patterns related to cCA125 and hCA125 revealed distinct differences in the patterns of arborescence. The ferning morphology of cCA125 antigen was denser than that of hCA125 antigen making an obvious difference between cCA125 and h... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5207361 Wed, 07 Sep 2011 04:00:00 +0100 5207361 http://www.medworm.com/index.php?rid=5207359&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21901276%26dopt%3DAbstract Authors: Végső G, Görög D, Fehérvári I, Nemes B, Doros A, Langer RM, Kóbori L Abstract There are only few malignant tumours where organ transplantation is the treatment of choice. Transplantation can be considered individually in certain lung carcinomas, unresectable heart tumours, cholangiocellular carcinoma and Klatskin tumour. It is acceptable in unresectable chemosensitive hepatoblastoma, epitheloid haemangioendothelioma, liver metastasis of neuroendocrine tumours and as the most common indication, the early hepatocellular carcinoma (HCC) in cirrhotic liver. Results of liver transplantation (LT) for HCC according to Milan criteria as a "gold standard" are excellent. Time of LT has a great influence on the results. While patients are on waiting list, locoregional therapie... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5207359 Wed, 07 Sep 2011 04:00:00 +0100 5207359 http://www.medworm.com/index.php?rid=5169349&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21866424%26dopt%3DAbstract Authors: Lau PC, Wong EY Abstract Nasopharyngeal carcinoma (NPC) represents a common cancer in endemic areas with high invasive and metastatic potential. It is now known that the HGF-MET signaling pathway plays an important role in mediating the invasive growth of many different types of cancer, including head and neck squamous cell carcinoma. HGF has been shown to stimulate NPC cell growth and invasion in cell line model. The current study aims at demonstrating the effect of MET inhibition by small molecule tyrosine kinase inhibitor PHA665752 on the growth and invasive potential of NPC cell lines. NPC cell lines were used for immunohistochemistry for the MET protein, as well as western blot analysis on MET together with its downstream cascade signaling proteins after treatment wit... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5169349 Wed, 24 Aug 2011 23:00:00 +0100 5169349 http://www.medworm.com/index.php?rid=5169350&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21861243%26dopt%3DAbstract Authors: He HC, Chen JH, Chen XB, Qin GQ, Cai C, Liang YX, Han ZD, Dai QS, Chen YR, Zeng GH, Zhu JG, Jiang FN, Zhong WD Abstract Hedgehog (Hh) pathway has been implicated in the tumorigenesis of a large number of human tumors. But its effects on the progression and prognosis of bladder cancer remain poorly understood. The aim of this study was to investigate expression patterns of Hh pathway components in bladder cancer and to elucidate their prognostic values in this tumor. The expression of sonic hedgehog (Shh), its receptor Patched (Ptch1), and downstream transcription factor Gli1 in 118 specimens of bladder cancer and 30 specimens of adjacent normal bladder tissue was determined by immunohistochemistry. Statistical analyses were applied to test the relationship between the expr... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5169350 Tue, 23 Aug 2011 23:00:00 +0100 5169350 http://www.medworm.com/index.php?rid=5127021&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21837482%26dopt%3DAbstract In this report, we describe a classic case of stroma rich neuroblastoma, nodular type in a 22 year old female presented with a pancreatic mass. This rare and unusual presentation elicits several differential diagnostic categories including solid pseudopapillary tumor, pancreatic endocrine tumor, pancreatoblastoma and PNET. In this report, we tried to differentiate between them depending on the histopathological features and using panel of epithelial and neuroendocrine markers. Although of the rarity of pancreatic neuroblastoma as a primary site of origin, however it should be considered in the differential diagnosis of pancreatic masses in children and young adult. Neuropil and ganglionic differentiation are helpful features to recognize neuroblastoma and differentiate them from other sma... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5127021 Thu, 11 Aug 2011 23:00:00 +0100 5127021 http://www.medworm.com/index.php?rid=5078855&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21796503%26dopt%3DAbstract In conclusion, we found CDH13 and FBLN3 gene methylation are potential biomarkers for poor prognosis in CRC. PMID: 21796503 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5078855 Wed, 27 Jul 2011 23:00:00 +0100 5078855 http://www.medworm.com/index.php?rid=5078856&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21792700%26dopt%3DAbstract In conclusion, the present study showed stronger pS6 expression and more frequent overexpression in metastases than in corresponding PRCCs. In approximately one-third of the cases pS6 overexpression was found exclusively in metastases, which is interesting with regard to the association between high pS6 expression and sensitivity to mTOR inhibitor therapy. PMID: 21792700 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5078856 Tue, 26 Jul 2011 23:00:00 +0100 5078856 http://www.medworm.com/index.php?rid=5078859&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21785902%26dopt%3DAbstract Authors: Kandemir NO, Barut F, Bektas S, Ozdamar SO Regional lymph node status is the primary parameter determining treatment strategies and prognoses in breast cancer. Lymphatic vessels in primary tumor tissue play a significant role in lymphatic metastasis. The aim of this study was to investigate the correlation of intra- and peritumoral lymphatic microvessel densities (LVD) with prognostic parameters in breast cancer, including lymphatic invasion (LI). Lymphangiogenesis was investigated using D2-40 monoclonal antibody in 69 invasive ductal carcinoma cases who underwent mastectomy and axillary lymph node dissection. Positively stained microvessels were counted at 400× in dense lymphatic vascular foci (hotspots). Tumor LI was established when at least one neoplastic cell cluster was... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5078859 Fri, 22 Jul 2011 23:00:00 +0100 5078859 http://www.medworm.com/index.php?rid=5078857&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21786090%26dopt%3DAbstract Authors: Vlachostergios PJ, Karasavvidou F, Patrikidou A, Voutsadakis IA, Kakkas G, Moutzouris G, Zintzaras E, Daliani DD, Melekos MD, Papandreou CN Prostate cancer (PCa) is a potentially curable disease when diagnosed in early stages and subsequently treated with radical prostatectomy (RP). However, a significant proportion of patients tend to relapse early, with the emergence of biochemical failure (BF) as an established precursor of progression to metastatic disease. Several candidate molecular markers have been studied in an effort to enhance the accuracy of existing predictive tools regarding the risk of BF after RP. We studied the immunohistochemical expression of p53, cyclooxygenase-2 (COX-2) and cyclin D1 in a cohort of 70 patients that underwent RP for early stage, hormone na�... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5078857 Fri, 22 Jul 2011 23:00:00 +0100 5078857 http://www.medworm.com/index.php?rid=5078858&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21785903%26dopt%3DAbstract Authors: Varga T, Somogyi A, Barna G, Wichmann B, Nagy G, Rácz K, Selmeci L, Firneisz G Dipeptidyl peptidase-4 (DPP-4) is involved in the metabolism of peptide hormones, T-cell activation and proliferation. In type 1 diabetes mellitus (T1DM) β-cell destruction involves a number of dysregulated T-cells. Our aim was to assess the serum DPP-4 activity and the lymphocyte membrane bound CD26 expression in patients with type 1 diabetes and healthy controls. Ninety-eight (T1DM: 48, F/M = 20/28, mean age: 34.4y; control: 50, F/M = 39/11 mean age: 32,4y) individuals were included. Fasting serum DPP-4 enzymatic activity, plasma glucose (FPG), CD26 expression on CD3+, CD4+ and CD8+ lymphocytes, HbA1c and body mass index (BMI) were assessed. ICA and GAD antibodies were assessed in the T1... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5078858 Thu, 21 Jul 2011 23:00:00 +0100 5078858 http://www.medworm.com/index.php?rid=5078862&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21773880%26dopt%3DAbstract Authors: Dunai Z, Bauer PI, Mihalik R Programmed cell death is a key component of tissue homeostasis, normal development and wide variety of diseases. Conventional view refers to programmed cell death form as caspase-mediated apoptosis while necrosis is considered as an accidental and unwanted cell demise, carried out in a non-regulated manner and caused by extreme conditions. However, accumulating evidences indicate that necrotic cell death can also be a regulated process. The term necroptosis has been introduced to describe a cell death receptor-induced, caspase-independent, highly regulated type of programmed cell death process with morphological resemblance of necrosis. Necroptosis recently has been found to contribute to a wide range of pathologic cell death forms including ischem... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5078862 Wed, 20 Jul 2011 23:00:00 +0100 5078862 http://www.medworm.com/index.php?rid=5078861&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21779787%26dopt%3DAbstract This study was aimed to quantify the circulating DNA in plasma from patients with hepatocellular carcinoma (HCC) using quantitative PCR and evaluate its potential clinical value. Blood samples were collected from 72 patients with HCC, 37 with liver cirrhosis or chronic hepatitis and 41 healthy volunteers. Plasma DNA was extracted and quantified by a real-time quantitative PCR method. The diagnostic and prognostic value of plasma DNA analysis for HCC was evaluated. DNA levels in the HCC plasma (median: 173 ng/mL) were significantly higher than those in the healthy controls (9 ng/mL) or control benign patients (46 ng/mL) (P < 0.001). The area under the receiver-operation characteristic (ROC) curve (AUC) assessing plasma DNA was 0.949 for healthy controls and 0.874 for control patie... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5078861 Wed, 20 Jul 2011 23:00:00 +0100 5078861 http://www.medworm.com/index.php?rid=5078860&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21779788%26dopt%3DAbstract Authors: Gumustekin M, Kargi A, Bulut G, Gozukizil A, Ulukus C, Oztop I, Atabey N Hepatocyte Growth Factor (HGF) and its receptor c-Met are suggested to play an important role in progression of solid organ tumors by mediating cell motility, invasion and metastasis. Overexpression of HGF and c-Met have been shown in non-small-cell lung cancer (NSCLC). However, their role in tumor progression is not clearly defined. The aim of this study is to determine the role of HGF/c-Met pathway and its association with invasion related markers and clinicopathologic parameters in NSCLC. Immunohistochemical analysis was performed on 63 paraffin-embedded NSCLC tumor sections. The expressions of invasion related markers such as Matrix Metalloproteinases (MMPs) 2 and 9, Tissue Inhibitor Metalloproteinase... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5078860 Wed, 20 Jul 2011 23:00:00 +0100 5078860 http://www.medworm.com/index.php?rid=5029604&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21750953%26dopt%3DAbstract We examined the expression of HSP70, HSP90, RB1, cyclin D1, and HDAC6 in 50 resections of human CCA tissues by quantitative real-time PCR. The expression of HSP70, RB1, and HDAC6 was "dominant down-regulation," while the expression of cyclin D1 and HSP90 was "dominant up-regulation." There were no correlations between RB1, cyclin D1, HSP90, and clinicopathological parameters such as status, histology type, histological grading, stage of CCA, and metastasis. A significant association was found between HDAC6 and CCA staging (p = 0.000), CCA gross type and HSP70 (p = 0.046) as well as RB1 expression (p = 0.046). Patients with down-regulation of HSP70 had significantly poorer prognosis than those in the up-regulation group (p = 0.002). Expression of HSP70 may be useful as a new... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5029604 Tue, 12 Jul 2011 23:00:00 +0100 5029604 http://www.medworm.com/index.php?rid=5029605&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21744007%26dopt%3DAbstract Authors: Karabon L, Pawlak-Adamska E, Tomkiewicz A, Jedynak A, Kielbinski M, Woszczyk D, Potoczek S, Jonkisz A, Kuliczkowski K, Frydecka I Various phenotype and functional T-cell abnormalities are observed in multiple myeloma (MM) patients. The aim of this study was to investigate the association between polymorphisms in the gene encoding cytotoxic T-lymphocyte antigen-4 (CTLA-4), a negative regulator of the T-lymphocyte immune response and susceptibility to multiple myeloma in a Polish population. Two hundred MM patients and 380 healthy subjects were genotyped for the following polymorphisms: CTLA-4c.49A>G, CTLA-4g.319C>T, CTLA-4g.*642AT(8_33), CT60 (CTLA-4g.*6230G>A), Jo31 (CTLA-4g.*10223G>T). Our study is the largest and most comprehensive evaluation to date of the assoc... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5029605 Fri, 08 Jul 2011 23:00:00 +0100 5029605 http://www.medworm.com/index.php?rid=5029606&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21725899%26dopt%3DAbstract In conclusion, Nek6 is involved in the pathogenesis of hepatocellular carcinoma. It may be a favorable independent poor prognostic parameter for hepatocellular carcinoma. PMID: 21725899 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5029606 Mon, 04 Jul 2011 23:00:00 +0100 5029606 http://www.medworm.com/index.php?rid=5029607&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21720852%26dopt%3DAbstract Authors: Mahmoodi M, Nahvi H, Mahmoudi M, Kasaian A, Mohagheghi MA, Divsalar K, Nahavandian B, Jafari A, Ansarpour B, Moradi B, Aghamohammadi A, Amirzargar A Based on the reports, few HLA class II alleles are associated with susceptibility or protection in breast cancer. Here we investigate the association between HLA class II alleles and breast cancer in Iranian women. 100 patients with pathologically proven breast cancer who referred to Cancer Institute were randomly selected and compared with a group of 80 healthy blood donor subjects. The patients were studied in two groups, group 1 includes patients aging 40 years or younger and group 2 include patients aging over 40 years. HLA class II alleles were determined by amplification of DNA followed by HLA-typing using sequence-specifi... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5029607 Thu, 30 Jun 2011 23:00:00 +0100 5029607 http://www.medworm.com/index.php?rid=5029608&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21717114%26dopt%3DAbstract Authors: Li L, Wang YY, Zhao ZS, Ma J To investigat the clinical significance of Ezrin in the development and progression of gastric cancer. Immunohistochemistry was employed to analyze Ezrin expression in 436 clinicopathologically characterized gastric cancer cases. Ezrin protein levels were up-regulated in gastric cancer lesions compared with adjacent noncancerous tissues. Positive expression of Ezrin correlated with age, size of tumor, location of tumor, depth of invasion, vessel invasion, lymph node and distant metastasis and TNM stage. In stages I, II and III, the 5 year survival rate of patients with a high expression of Ezrin was significantly lower than those in patients with low expression. In stage IV, Ezrin expression did not correlate with the 5 year survival rate. Furthe... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=5029608 Wed, 29 Jun 2011 23:00:00 +0100 5029608 http://www.medworm.com/index.php?rid=4984904&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21713600%26dopt%3DAbstract Authors: Fauzee NJ, Li Q, Wang YL, Pan J Poly ADP-ribose polymerase (PARP) which is closely related to Poly ADP-ribose glycohydrolase (PARG) has already been thoroughly investigated in both experimental and clinical cancer trials compared to the latter. Nevertheless, in this experiment the importance of PARG expression was highlighted; whereby it is being silenced via lentivirus vector-mediated short hairpin RNA (shRNA). MTT assay showed that there was an inhibition in human Lovo colon cancer cell growth and flow cytometry demonstrated an increase in the population of cells in G(0)/G(1) phase with a decrease in the S phase in transfected Lovo cells. Furthermore, our results suggested that the effect of silencing PARG leads to the inhibition of PARP expression; related to a decrease in ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984904 Wed, 29 Jun 2011 23:00:00 +0100 4984904 http://www.medworm.com/index.php?rid=4984903&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21713601%26dopt%3DAbstract Authors: Li D, Cui Q, Liu Y, Wang X, Liu C, Liu S, Zeng Y To summarize the experience in intraarterial neoadjuvant chemotherapy for extremity osteosarcoma. Between January 2002 and December 2007,111 patients with stage IIB extremity osteosarcoma received preoperative intraarterial therapy with subcutaneous implantation of chemotherapy pump as well as en bloc resection, and postoperative adjuvant chemotherapy. There were 63 males and 48 females with an average age of 18 (range, 14 ~ 39 years). The time from symptom onset to hospitalization varied from several days to 6 months. The induction chemotherapy regimen includes: epirubicin [50 ~ 70 mg/m(2) by 4-hour intraarterial infusion/day for 3 day] and cisplatin [100 ~ 120 mg/m(2) by 2-hour intraarterial infusion/day for 3... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984903 Wed, 29 Jun 2011 23:00:00 +0100 4984903 http://www.medworm.com/index.php?rid=4984905&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21706277%26dopt%3DAbstract Authors: Sugunadevi G, Suresh K, Vijayaanand MA, Rajalingam K, Sathiyapriya J The present study was aimed to evaluate the antigenotoxic effect of Mosinone-A on 7,12-dimethylbenz[a]anthracene induced genotoxicity. The frequency of micronucleated polychromatic erythrocytes [MnPCEs], chromosomal aberrations [CA], DNA damage (comet assay) as cytogenetic markers and the status of lipid peroxidation byproducts, antioxidants and phase II detoxification agents were used as biochemical markers to assess the antigenotoxic effect of Mosinone-A on DMBA induced genotoxicity. A single intraperitoneal injection of DMBA (30 mg/kg b.wt) to golden Syrian hamsters, resulted in marked elevation in the frequency of MnPCEs, aberrations in the chromosomal structure were found in bone marrow and DNA damage (... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984905 Fri, 24 Jun 2011 23:00:00 +0100 4984905 http://www.medworm.com/index.php?rid=4984906&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21695587%26dopt%3DAbstract This study showed DG expression was gradually reduced during tumor progression. Different expression of α-DG, but not β-DG, between primary tumor and normal specimen, correlated with patient survival, implicating a potential marker for gastric cancer prognosis. PMID: 21695587 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984906 Tue, 21 Jun 2011 23:00:00 +0100 4984906 http://www.medworm.com/index.php?rid=4984908&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21688087%26dopt%3DAbstract Authors: Tóth B, Katona M, Hársing J, Szepesi A, Kárpáti S The 15-year-old male patient presented several 2-6 mm large livid reddish-yellowish, shiny, compact papules on the head, trunk and extremities, which had developed within the last 4 months. Histology showed normal epidermis with dense dermal infiltrate of histiocytes accompanied by few eosinophils, Touton or foamy giant cells. The histiocytes were S100 positive, CD1a negative and did not contain Birbeck granules ultrastructurally. Chest X ray, EEG, skull MRI did not show pathology. Opthalmology, neurology, oto-rhino-laryngology did not reveal alterations. Based upon the clinical symptoms and the histopathology, the diagnosis of indeterminate cell histiocytosis was confirmed. Cryotherapy and cauterization did not stop the ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984908 Sat, 18 Jun 2011 23:00:00 +0100 4984908 http://www.medworm.com/index.php?rid=4984907&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21688200%26dopt%3DAbstract Authors: Xiong X, Ren HZ, Li MH, Mei JH, Wen JF, Zheng CL To detect the expression of miRNA-214 in human gastric cancer cell lines of BGC823, MKN45 and SGC7901, and to identify the effect of miRNA-214 on cell cycle and apoptosis of these cells. Expression of miRNA-214 in human normal gastric mucosal cell line GES-1 and human gastric cancer cell lines was detected by real-time reverse-transcription polymerase chain reaction. Antisense-miRNA-214 oligonucleotides were transfected transiently into gastric cancer cell lines to down-regulate the expression of miRNA-214. The cell cycle and apoptosis were studied by flow cytometry assay. PTEN, one of the target genes of miRNA-214 was detected by using of immunocytochemistry and Western blotting. MiRNA-214 was overexpressed in gastric cancer ce... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984907 Sat, 18 Jun 2011 23:00:00 +0100 4984907 http://www.medworm.com/index.php?rid=4984914&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21681600%26dopt%3DAbstract This study investigates CD10 expression in epithelial and stromal cells of non small cell lung carcinoma (NSCLC), and evaluates its prognostic value for this tumor and its histologic subtypes. Sixty-six cases of NSCLC [35 cases of nonsquamous cell carcinoma (NSCC) and 31 cases of squamous cell carcinoma (SCC)] were analyzed immuno-histochemically for CD10 antibody. Fisher's exact test and univariate survival analyses were performed. Comparison of clinicopathologic characteristics for NSCLC showed that only stromal CD10 expression had worse prognostic impact, associated with the presence of recurrence (p = 0.001), death (p = 0.006) and disease positivity (p = 0.001). For SCC, CD10 was found to be expressed mainly in the stromal cells, and was associated with a decreased survival... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984914 Fri, 17 Jun 2011 23:00:00 +0100 4984914 http://www.medworm.com/index.php?rid=4984913&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21681601%26dopt%3DAbstract Authors: Nikolényi A, Uhercsák G, Csenki M, Hamar S, Csörgő E, Tánczos E, Thurzó L, Brodowicz T, Wagnerova M, Kahán Z There is a need for the selection of those breast cancers where benefit may be attained from the addition of an anthracycline to the adjuvant chemotherapy. The expression of topoisomerase II alpha (TOP2A) protein in 3 cohorts of breast cancers treated with adjuvant dose-dense anthracycline-based chemotherapy was determined retrospectively. The TOP2A status was analysed in relation with the other standard tumour features and the outcome. TOP2A IHC results were assessable in 106 patients: with a cut-off value of 15%, 48% of the tumours were classified as TOP2A-positive. The expression of TOP2A correlated with that of Ki67 (R = 0.532, p < 0.001) and a hig... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984913 Fri, 17 Jun 2011 23:00:00 +0100 4984913 http://www.medworm.com/index.php?rid=4984912&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21681602%26dopt%3DAbstract Authors: Liu X, He Z, Li CH, Huang G, Ding C, Liu H Janus kinases (JAK)/signal transducers and activator of transcription (STAT) pathway is activated constitutively in prostate cancer (PCa). Despite previous reports implying a role of this pathway in the development of clinical hormone-refractory PCa, the correlation of pathway members with the clinicopathologic features and prognosis of patients with PCa has not been elucidated. To address this problem, pJAK-1(Tyr1022/1023) and pSTAT-3(Tyr705) were evaluated by immunostaining in needle biopsies of the prostate from 202 PCa patients treated by definitive therapy (105 cases) or hormonal therapy (97 cases). The correlation of two protein expression with the clinicopathologic features and the prognosis of PCa were subsequently assessed. T... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984912 Fri, 17 Jun 2011 23:00:00 +0100 4984912 http://www.medworm.com/index.php?rid=4984909&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21688086%26dopt%3DAbstract This study implies that Annexin A2 might play an important role in the progression and invasion of human lung cancer cells, and could promote progression of lung cancer by regulating the expression of MMP-2 and CB. PMID: 21688086 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984909 Fri, 17 Jun 2011 23:00:00 +0100 4984909 http://www.medworm.com/index.php?rid=4984911&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21681603%26dopt%3DAbstract Authors: Faccion RS, Ferreira RM, Grabois MF, Fonseca TC, de Oliveira JA, Maia RC Medulloblastoma (MDB) is the most common malignant cerebellar tumor in children. Because of the significant rate of mortality and treatment-related morbidity, the identification of prognostic factors could lead to a more accurate selection of patients who can benefit from a less aggressive therapy and improve risk stratification. Survivin is an inhibitor of apoptosis protein (IAP), the expression of which has been associated with worse prognosis in MDB. However, both of its subcellular localizations may contribute to tumor progression, and ultimately, survivin subcellular localization prognostic value depends on tumor type biological features. The goal of this study was to analyze these survivin features ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984911 Thu, 16 Jun 2011 23:00:00 +0100 4984911 http://www.medworm.com/index.php?rid=4984910&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21681604%26dopt%3DAbstract Authors: Bene L, Falus A, Baffy N, Fulop AK The factors involved in the pathogenesis of Crohn's disease and ulcerative colitis, the two major types of inflammatory bowel disease (IBD) are summarized. Intestinal antigens composed of bacterial flora along with antigen presentation and impaired mucosal barrier have an important role in the initiation of IBD. The bacterial community may be modified by the use of antibiotics and probiotics. The dentritic cells recognize the antigens by cell surface Toll like receptor and the cytoplasmic CARD/NOD system. The balance between Th1/Th2/Th17 cell populations being the source of a variety of cytokines regulates the inflammatory mechanisms and the clearance of microbes. The intracellular killing and digestion, including autophagy, are important in ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984910 Thu, 16 Jun 2011 23:00:00 +0100 4984910 http://www.medworm.com/index.php?rid=4984917&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21678108%26dopt%3DAbstract Authors: Lakatos G, Sipos F, Miheller P, Hritz I, Varga MZ, Juhász M, Molnár B, Tulassay Z, Herszényi L Matrix metalloproteinases play an important role in extracellular matrix remodelling. It has been proposed that matrix metalloproteinase-9 (MMP-9) is involved in epithelial damage in ulcerative colitis (UC). However, to our knowledge, no data are available in terms of MMP-9 expression in microscopic colitis. Determination of mucosal protein expression levels of MMP-9 in lymphocytic colitis (LC), collagenous colitis (CC) and UC. MMP-9 immunohistochemical expressions were analyzed in paraffin-embedded tissue samples by immunohistochemistry including patients with LC, CC, UC, active diverticulitis, inactive diverticular disease and healthy control subjects. UC was also subgrouped acc... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984917 Wed, 15 Jun 2011 23:00:00 +0100 4984917 http://www.medworm.com/index.php?rid=4984916&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21678109%26dopt%3DAbstract Authors: Stanczak A, Stec R, Bodnar L, Olszewski W, Cichowicz M, Kozlowski W, Szczylik C, Pietrucha T, Wieczorek M, Lamparska-Przybysz M Wnt/β-catenin pathway plays an important role in initiation and progression of colorectal oncogenesis. The aim of this study was to determine expression and localization of E-cadherin, β-catenin and Wnt-1 proteins in colorectal tumors. Expression of β-catenin, E-cadherin and Wnt-1 was determined by immunohistochemistry on advanced colorectal cancers. Abnormal expression of E-cadherin, β-catenin, Wnt-1 was observed. Additionally, we revealed correlations between levels of studied proteins and histoclinical data. In multivariate analysis nuclear β-catenin, higher carcinoembryonic antigen serum level before treatment, female sex and tumor localized ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984916 Wed, 15 Jun 2011 23:00:00 +0100 4984916 http://www.medworm.com/index.php?rid=4984915&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21678110%26dopt%3DAbstract Authors: Cerne JZ, Frkovic-Grazio S, Gersak K The aim of this study was to further elucidate the influence of HRT use, regarding duration, regimen and route of administration, on breast tumor characteristics. We evaluated the associations between HRT use and breast tumor characteristics in 530 postmenopausal women diagnosed with invasive breast cancer. Detailed information on HRT use and mammographic attendance were collected through a postal questionnaire. Adjusted odds ratios and 95% confidence intervals were calculated using logistic regression. Tumors in HRT users were significantly smaller, more often of ductal histologic type and with lower grade and lower mitotic index compared to tumors in nonusers. Tumor characteristics did not vary significantly by HRT duration, regimen and r... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4984915 Wed, 15 Jun 2011 23:00:00 +0100 4984915 http://www.medworm.com/index.php?rid=4931806&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674249%26dopt%3DAbstract In this study, we investigated the correlation between KLF4 and KLF5 expression and the clinical manifestations of breast cancer by immunohistochemical analysis. We observed increased KLF4 and KLF5 expression in tumor cells (invasive and in situ carcinomas), consistent KLF4 and KLF5 expression in in situ and invasive carcinomas, significant associations between KLF4 expression and tumor grade (p = 0.033), size (p = 0.035) and stage (p = 0.006), and an association between KLF5 expression and tumor grade (p = 0.033). Interestingly, we observed a relationship between increasing age and KLF4 expression (p = 0.007), with a tendency towards greater expression in tumor cells in patients over 50 years old. Moreover, KLF5 nuclear localization was restricted to non-tumor breast ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931806 Tue, 14 Jun 2011 23:00:00 +0100 4931806 http://www.medworm.com/index.php?rid=4931803&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21674250%26dopt%3DAbstract In this study, we investigated tumor-free neighboring stroma and tumor stroma in squamous cell carcinomas (SCCs) of the skin as well as keratoacanthomas (KAs) with respect to the presence of stromal CD34-positive (CD34+) fibrocytes and α-smooth muscle actin-positive (α-SMA+) myofibroblasts using seborrheic keratosis (SKs) and non-tumoral skin samples as controls. We also evaluated the stromal expression pattern of CD26/DPPIV (CD26), a tumor suppressor gene product that also has immunoregulatory properties. Immunohistochemistry was performed on samples of 31 SCC, 8 KA, 15 SK and 10 non-tumoral skin samples. Peri-tumoral stroma from resection margins was also evaluated. We found that CD34 and α-SMA demonstrated significantly different staining between benign and malignant squamous skin le... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931803 Tue, 14 Jun 2011 23:00:00 +0100 4931803 http://www.medworm.com/index.php?rid=4931813&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21667346%26dopt%3DAbstract Authors: Váróczy L, Zilahi E, Gyetvai A, Kajtár B, Gergely L, Sipka S, Illés A The addition of rituximab to conventional chemotherapy has significantly improved the treatment outcome in diffuse large B-cell lymphoma. However, differences in treatment response and survival data can be observed independently from the International Prognostic Index scores. The current study evaluated the impact of Fc-gamma-receptor IIIa polymorphism and gene expression profile on the response of DLBCL patients to R-CHOP therapy as well as on their survival results. Fifty-one patients were involved, thirty-two females, nineteen males, their median age was 53.1 years. The FCGR3A polymorphism at the 158. amino acid position determined with PCR method showed the following results: VV: 12 cases (23.5%), V... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931813 Mon, 13 Jun 2011 23:00:00 +0100 4931813 http://www.medworm.com/index.php?rid=4931810&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21671140%26dopt%3DAbstract CONCLUSIONS: In breast cancer cases, the major molecules regulating NO and VEGF production can be co-expressed in the individual carcinomas implying a possibility for the relevant pathways to be active; however appropriate functional experiments remain to be conducted to prove such a hypothesis. PMID: 21671140 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931810 Mon, 13 Jun 2011 23:00:00 +0100 4931810 http://www.medworm.com/index.php?rid=4931817&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21667345%26dopt%3DAbstract Authors: Kallen ME, Nunes Rosado FG, Gonzalez AL, Sanders ME, Cates JM Expression of p63, a putative marker for epithelial or myoepithelial differentiation, has been used to distinguish spindle cell carcinoma from sarcoma. The specificity of p63 for epithelial differentiation has not been thoroughly evaluated however, since p63 expression has been explored in only a handful of mesenchymal tumors. After observing unexpected immunohistochemical staining for p63 in an angiosarcoma of the breast, we evaluated a series of benign and malignant vascular tumors to determine the frequency of such a finding. Nuclear immunoreactivity to p63 was detected, at least focally, in 24% of malignant vascular tumors other than Kaposi sarcoma, which was uniformly negative. Benign vascular tumors were also ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931817 Sun, 12 Jun 2011 23:00:00 +0100 4931817 http://www.medworm.com/index.php?rid=4931828&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21667305%26dopt%3DAbstract We report a case of a 75-year-old woman, presenting with abdominal pain and complaints of weakness and lost of appetite, who was found to have a mass on her right colon. She underwent right hemicolectomy for a pT3N2M0, stage IIIC colon cancer. The tumor phenotype and immunophenotype, as documented by alpha-fetoprotein immunoreaction positivity, were consistent with adenocarcinoma of hepatoid origin. The patient received FOLFOX-4 regimen as adjuvant treatment, relapsed after six cycles, then was switched to FOLFIRI regimen plus Bevacizumab and progressed after only four cycles. She died 1 month later, eight months after the diagnosis. The lack of any clinical benefit despite an aggressive and multimodal therapeutic strategy, raises a question about what should be targeted when we face this... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931828 Sat, 11 Jun 2011 23:00:00 +0100 4931828 http://www.medworm.com/index.php?rid=4931826&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21667306%26dopt%3DAbstract In this study, we investigated PIK3CA mutation in Chinese hepatocellular carcinoma patients. A total 90 Chinese patients of hepatocellular carcinoma were recruited in this study. Exons 9 and 20 hotspots mutations of PIK3CA gene were detected by PCR-based DNA sequencing. Two point mutations (E542K and D549H) in exon 9 were found in only one patient (1/90; 1.11%), no mutation was found in exon 20 in any cases. 57 patients are associated with HBV infection (57/90; 63.3%), and 8 patients with HCV infection (8/90; 8.9%). The frequency of the PIK3CA mutations in hepatocellular carcinoma seems to be lower in Chinese hepatocellular carcinoma patients. These findings suggest that PI3K mutations may not play a major role in hepatic carcinogenesis in Chinese. HBV infection has close relationship with... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931826 Sat, 11 Jun 2011 23:00:00 +0100 4931826 http://www.medworm.com/index.php?rid=4931830&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21667221%26dopt%3DAbstract Authors: Juhász E, Béres J, Kanizsai S, Nagy K Frequencies of genetic polymorphisms of the three most frequent HIV-1 resistance-conferring alleles playing an important role in HIV-1 pathogenesis were analysed in Vlach Gypsy populations living in Hungary, as the largest minority. Mutations in the encoding genes, such as CCR5-∆32, CCR2-64I and SDF1-3'A are shown to result in protective effects against HIV-1 infection and disease progression. 560 samples collected from Vlach Gypsy individuals living in 6 North-East Hungarian settlements were genotyped by PCR-RFLP method. Overall allele frequencies of CCR5-∆32, CCR2-64I and SDF1-3'A were found as 0.122, 0.186 and 0.115 respectively. All the observed genotype frequencies were in accordance with Hardy-Weinberg equilibrium . In regions,... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931830 Fri, 10 Jun 2011 23:00:00 +0100 4931830 http://www.medworm.com/index.php?rid=4931831&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21660524%26dopt%3DAbstract In this study, we report the favorable outcome of the activated B-cell type of DLBCL, though untreated, 7 years after diagnosis. In 2003, DLBCL localized to the root of tongue was found in the patient complaining of dysphonia and a pharyngeal globus perception but the patient did not agree to get any active hematological treatment. During the following years, the patient did not have any complaints. At the otorhinolaryngological control examination, in 2010, she was complaint-free, had normal laboratory parameters. Moreover a PET-CT scan did not reveal metabolic activity relating to malignancy. The extraordinary disease process can be explained by the spontaneous regression of the activated B-cell type DLBCL. Spontaneous regression of oral lymphoma has been published only exceptionally. T... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931831 Thu, 09 Jun 2011 23:00:00 +0100 4931831 http://www.medworm.com/index.php?rid=4931835&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21647780%26dopt%3DAbstract Authors: Rouissi K, Ouerhani S, Hamrita B, Bougatef K, Marrakchi R, Cherif M, Ben Slama MR, Bouzouita M, Chebil M, Ben Ammar Elgaaied A Cancer epidemiology has undergone marked development since the nineteen-fifties. One of the most spectacular and specific contributions was the demonstration of the massive effect of smoking and genetic polymorphisms on the occurrence of bladder cancer. The tobacco carcinogens are metabolized by various xenobiotic metabolizing enzymes, such as the super-families of N-acetyltransferases (NAT) and glutathione S-transferases (GST). DNA repair is essential to an individual's ability to respond to damage caused by tobacco carcinogens. Alterations in DNA repair genes may affect cancer risk by influencing individual susceptibility to this environmental exposu... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931835 Tue, 07 Jun 2011 23:00:00 +0100 4931835 http://www.medworm.com/index.php?rid=4931833&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21655924%26dopt%3DAbstract Authors: Rasti M, Arabsolghar R, Khatooni Z, Mostafavi-Pour Z p53 is a tumor suppressor protein that regulates estrogen receptor 1 (ESR1) expression. To investigate the mechanism of ESR1 gene regulation by p53, chromatin immunoprecipitation was applied to assess the binding of p53, DNMT1, HDAC1 and MeCP2 to both silenced ESR1 promoter in MDA-MB-468 cells and active ESR1 promoter in MCF-7 breast cancer cells. The results of chromatin immunoprecipitation experiments showed that p53 protein binds to both unmethylated CpG island of the ESR1 promoter in the ER-positive MCF-7 and the hypermethylated ESR1 promoter in the ER-negative MDA-MB-468 cells. However, repression complex including DNMT1, HDAC1 and MeCP2 is only associated with silenced ESR1 in ER-negative MDA-MB-468 human breast cancer... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931833 Tue, 07 Jun 2011 23:00:00 +0100 4931833 http://www.medworm.com/index.php?rid=4931832&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21655925%26dopt%3DAbstract In this study we evaluated the safety of expectant approach in the patients with low risk prostate cancer in the reality of community based out-patients clinics. 48 men were enrolled into the study. The inclusion criteria were age ranged from 60 to 75 years and the Epstein criteria for low risk prostate cancer. Patients were managed expectantly while curative treatment was offered when indicated. Initial and final Charlson comorbidity index (CCI) and BMI were assessed for all men. Patients' median follow-up was 81.1 ± 29.1 years. During this study 41.7% of the patients chose active forms of treatment. Cancer was found in 20.8% (n-10) of our patients. Two first sessions of re-biopsy diagnosed 92% of T1c upgrading. Six men with CCI ≥2 died from concomitant disease and no one died fr... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931832 Tue, 07 Jun 2011 23:00:00 +0100 4931832 http://www.medworm.com/index.php?rid=4931836&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21647779%26dopt%3DAbstract Authors: Bojková B, Garajová M, Péč M, Kubatka P, Kajo K, Mokáň M, Kassayová M, Orendáš P, Kisková T, Ahlersová E, Ahlers I In this paper, the effect of peroral antidiabetic pioglitazone, a thiazolidinedione derivate, on selected parameters of carbohydrate and lipid metabolism in N-methyl-N-nitrosourea-induced mammary carcinogenesis in female Sprague-Dawley rats was evaluated. Pioglitazone was administered in the diet at two concentrations (10 ppm and 100 ppm), the chemoprevention was initiated 12 days before carcinogenesis induction and lasted until the termination of the experiment. The experiment was terminated 17 weeks after carcinogenesis induction, selected organs and tissues were removed and weighed and basic metabolic and hormonal parameters were determined. Piog... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931836 Mon, 06 Jun 2011 23:00:00 +0100 4931836 http://www.medworm.com/index.php?rid=4931834&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21647781%26dopt%3DAbstract Authors: Liu Q, Lin JX, Shi QL, Wu B, Ma HH, Sun GQ Primary peritoneal serous papillary carcinoma (PPSPC) is a rare primary tumor of the peritoneum that found predominantly in elderly and post-menopausal women. The aim of our study is to review the clinical and pathologic information of 22 patients, and then try to summarize clinical behavior and pathological characteristics of PPSPC, in order to be better recognized of this entity in future. We retrospectively reviewed the data from 22 patients with PPSPC treated at our hospital from 1992 to 2008. All paraffin blocks were recut for periodic acid-Schiff diastase and immunohistochemical staining for CD15, cytokeratin7(CK7), cytokeratin20(CK20), S-100 protein, carcinoembryonic antigen (CEA), CA125, estrogen receptor(ER) and progesterone ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4931834 Mon, 06 Jun 2011 23:00:00 +0100 4931834 http://www.medworm.com/index.php?rid=4885295&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21626441%26dopt%3DAbstract Authors: Terada T PMID: 21626441 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4885295 Mon, 30 May 2011 23:00:00 +0100 4885295 http://www.medworm.com/index.php?rid=4885294&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21626442%26dopt%3DAbstract Authors: You Q, Wang XS, Fu SB, Jin XM Colorectal cancer has a high cure rate if it can be detected early. Identifying and understanding the genes involved may enable early diagnosis and reduce mortality. The aim of our study was to investigate the correlation between the expression of ING4 and the pathological features in patients with colorectal cancer. We assayed ING4 protein expression levels in tumor samples from 97 patients diagnosed with colorectal cancer between January 2001 and January 2002. The patients received no other treatments except surgery. ING4 protein expression was downregulated in adenoma relative to normal mucosa and further reduced in colorectal cancer tissues. Furthermore, the suppression of ING4 expression was also related to the more advanced Dukes' stages. We... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4885294 Mon, 30 May 2011 23:00:00 +0100 4885294 http://www.medworm.com/index.php?rid=4833885&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21560015%26dopt%3DAbstract Authors: Rykala J, Przybylowska K, Majsterek I, Pasz-Walczak G, Sygut A, Dziki A, Kruk-Jeromin J Tumoural angiogenesis is essential for the growth and spread of breast cancer cells. Therefore the aim of this study was to assess the diagnostic performance of angiogenesis markers in tumours and there reflecting levels in serum of breast cancer patients. Angiogenin, Ang2, fibroblast growth factor basic, intercellular adhesion molecule (ICAM)-1, keratinocyte growth factor (KGF), platelet-derived growth factor-BB, and VEGF-A were measured using a FASTQuant angiogenic growth factor multiplex protein assay. We observed that breast cancer tumours exhibited high levels of PDGF-BB, bFGF and VEGF, and extremely high levels of TIMP-1 and Ang-2, whereas in serum we found significantly higher levels... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4833885 Tue, 10 May 2011 23:00:00 +0100 4833885 http://www.medworm.com/index.php?rid=4833886&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21553350%26dopt%3DAbstract In conclusion, our present study indicated that expression of stemness genes (c-Myc, PTEN, p57 and p21) performed different predictive potential in the evaluation of clinical malignancy levels in gastric cancer. PMID: 21553350 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4833886 Mon, 09 May 2011 23:00:00 +0100 4833886 http://www.medworm.com/index.php?rid=4833887&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21553343%26dopt%3DAbstract In this study, we selected five pairs of PA and the surrounding normal salivary gland tissues. The total RNA was isolated from tumor and normal tissues and purified to mRNA. The mRNA was reverse-transcribed to cDNA with the incorporation of fluorescent-labeled dUTP to prepare the hybridization probes. The mixed probes were hybridized to Whole Human Gene Expression Microarrays by Agilent. Tumor-related genes were screened by analyzing the fluorescence intensity. As a result, a total of 447 genes were found to be differentially expressed between PA and normal tissue adjacent to PA. Among them, 185 genes were up-regulated and 262 genes were down-regulated in PA. By constructing a network from the differentially expressed genes, some genes, such as Gli2 and CTNNB1, were identified as being at ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4833887 Sun, 08 May 2011 23:00:00 +0100 4833887 http://www.medworm.com/index.php?rid=4781102&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21499820%26dopt%3DAbstract Authors: Cai C, Jiang FN, Liang YX, He HC, Han ZD, Dai QS, Qin GQ, Chen JH, Chen XB, Chen YR, Zeng GH, Zhu JG, Zhong WD Nuclear factor-κB (NF-κB) is controlled by the classical and alternative NF-κB pathways, the role of which in prostate cancer (PCa) is not clearly defined. To provide this missing translational link, we compared the classical and alternative NF-κB pathways in normal prostate, benign prostate hyperplasia (BPH) and PCa. Prostate specimens were divided into three groups: group A, PCa (n = 68); group B, BPH (n = 60); and group C, normal prostates (n = 15). The gene expression levels of NF-κB1 and NF-κB2 were determined by real-time quantitative RT-PCR. Additionally, we analyzed the expression and sub-cellular localization of phosphorylated P50 (p-P50) an... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4781102 Fri, 15 Apr 2011 23:00:00 +0100 4781102 http://www.medworm.com/index.php?rid=4781103&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21494849%26dopt%3DAbstract This study suggests that a significant fraction of micrometastases can be missed by traditional singleslice sectioning; half of the micrometastases would have been overlooked in our data set of 311 nodes. PMID: 21494849 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4781103 Thu, 14 Apr 2011 23:00:00 +0100 4781103 http://www.medworm.com/index.php?rid=4781104&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21491161%26dopt%3DAbstract We report a case of a 52-year-old female with synovial sarcoma of the uterine corpus. Grossly, the partly polypoid tumor involved the endometrium with invasion into the inner half of the myometrium. Histologically, the tumor showed biphasic structure with the predominance of poorly differentiated small to medium sized round to oval cells. These cells showed high nuclear to cytoplasmic ratio and were arranged in diffuse sheets. Other component consisted of larger epitheloid cells with ample eosinophilic cytoplasm arranged in irregular nests. These cells were only present in a small amount. Immunohistochemically, the tumor cells in both components showed the expression of EMA, S-100 protein, CD99, and NSE. RT-PCR analysis showed the presence of SYT-SSX1 fusion transcript. At present, the pat... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4781104 Wed, 13 Apr 2011 23:00:00 +0100 4781104 http://www.medworm.com/index.php?rid=4781105&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21487776%26dopt%3DAbstract Authors: Tamás L, Szentkúti G, Erős M, Dános K, Brauswetter D, Szende B, Zsákovics I, Krenács T We tested the expression of known (p16(ink4), Ki67, p53, EGFR) and a new immunohistochemical (collagen XVII/BP180) biomarker in head and neck squamous cell carcinomas (SCC) of diverse anatomical localization. Tissue microarrays (TMA) of 124 SCC were created, immunostained, and analyzed following whole slide digitalization using the Pannoramic Scan and the TMA Module software (3DHISTECH Kft, Budapest, Hungary). Statistical analysis of scoring results was carried out using Pearson's chi-square test. We observed the significant elevation of p16(ink4) and Ki67 expression in supraglottic, tonsillar and tonsillo-lingual SCCs compared to those affecting the oral cavity, oropharynx without ton... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4781105 Tue, 12 Apr 2011 23:00:00 +0100 4781105 http://www.medworm.com/index.php?rid=4781107&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21479874%26dopt%3DAbstract This study examined D2-40 immunoexpression in 178 classical KS lesions using immunohistochemical methods. D2-40 immunoexpression was also examined in 63 non-KS soft tissue lesions to test the reliability of D2-40 monoclonal antibody in the pathological diagnosis of KS. D2-40 immunoreactivity was detected at all of the KS lesions and in lymphangioma and nonneoplastic lymphatic endothelium. There was no significant relationship between the extent of D2-40 staining and histopathological stage; however, there was a positive correlation between the staining intensity and histopathological stage in KS cases. D2-40 immunoreactivity was detected at all histopathological stages of KS and may be added to the routine immunohistochemical panel used for the differential diagnosis of KS. Widespread D2-4... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4781107 Sat, 09 Apr 2011 23:00:00 +0100 4781107 http://www.medworm.com/index.php?rid=4781106&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21479875%26dopt%3DAbstract Authors: Caldarella A, Crocetti E, Bianchi S, Vezzosi V, Urso C, Biancalani M, Zappa M The aim of this study is to evaluate the prognostic values of some biological parameters in a population based series of female breast cancer patients. Through the Tuscan Cancer Registry all the invasive breast cancer cases diagnosed during the period 2004-2005 in the provinces of Florence and Prato, central Italy, were retrieved. Molecular subtypes were analyzed defined by immunohistochemical markers, by age, tumor size, lymph node status, histotype, grade of differentiation and proliferative marker. Out of 1487 patients 70.3% were luminal A subtype (ER/PR + HER2-), 15.6% luminal B (ER/PR + HER2+), 8.1% triple negative (ER/PR-HER2-), 6.0% HER2+ (ER/PR-HER2+); the 3 year survival rates were ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4781106 Sat, 09 Apr 2011 23:00:00 +0100 4781106 http://www.medworm.com/index.php?rid=4781108&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21476126%26dopt%3DAbstract Authors: Caldarella A, Crocetti E, Paci E Neuroendocrine tumors are considered rare tumors: recently an increased incidence and an improvement in survival were described. We explore distribution, incidence and survival of neuroendocrine tumors using population based registry data. We extracted from the Tuscan Cancer Registry neuroendocrine tumors from 1985-2005, and we evaluated distribution, incidence ad survival according to sex, site of tumor, age and stage at diagnosis. 455 cases of neuroendocrine tumors were identified. The overall incidence increased over the study period from 0.7 per 100,000 per year to 1.6 among men (APC +3.6) and from 0.3 to 2.1 among women (APC +4.8). The anatomic distribution of tumors was lung 25.7%, small intestine 23.5%, appendix 10.9%, colon 10.3%, panc... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4781108 Fri, 08 Apr 2011 23:00:00 +0100 4781108 http://www.medworm.com/index.php?rid=4781109&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21465252%26dopt%3DAbstract Authors: Patara M, Santos EM, Coudry RD, Soares FA, Ferreira FO, Rossi BM Ezrin protein acts in the regulation of cytoskeletal and directly influences survival and tumor progression; there is an increase in its expression in metastatic cells and tissues in several types of cancer including colorectal cancer. 250 Patients with colorectal cancer submitted to surgery from 1995 to 2002. Protein expression was carried through by Tissue Micro Array immunohistochemical tests of paraffined neoplasic tissues and associated with clinical variables. Differentiation degree, lymph node invasion, metastasis at diagnosis, and palliative surgery were associated to a higher expression of the protein and survival. Higher expression of the Ezrin correlates with tumor aggressiveness and worse prognosis fo... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4781109 Mon, 04 Apr 2011 23:00:00 +0100 4781109 http://www.medworm.com/index.php?rid=4676467&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21461997%26dopt%3DAbstract Authors: Vicha A, Holzerova M, Krepelova A, Musil Z, Prochazka P, Sumerauer D, Kodet R, Eckschlager T, Jarosova M Pheochromocytomas (PCCs) are rare tumors among children and adolescents and therefore are not genetically well characterized. The most frequently observed chromosomal changes in PCC are losses of 1p, 3q and/or 3p, 6q, 17p, 11q, 22q, and gains of 9q and 17q. Aberrations involving chromosome 11 are more common in malignant tumors. Unfortunately information about gene aberrations in childhood PCC's is limited. We used comparative genomic hybridization (CGH) and array comparative genomic hybridization (aCGH) to screen for copy number changes in four children suffering from pheochromocytoma or paraganglioma. Patients were diagnosed at the age 13 or 14 years. Bilateral pheochrom... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676467 Mon, 04 Apr 2011 23:00:00 +0100 4676467 http://www.medworm.com/index.php?rid=4676468&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21461979%26dopt%3DAbstract Authors: Ruppenthal RD, Nicolini C, Filho AF, Meurer R, Damin AP, Rohe A, Alexandre CO, Damin DC TWIST1 gene, a transcription factor that belongs to the family of basic helix-loop-helix proteins, has been related to tumor progression and metastasis in different cancers. The aim of our study was to investigate TWIST1 promoter methylation in patients with primary colorectal carcinoma and determine its correlation with prognostic factors and disease outcome. Seventy-three patients with primary colorectal adenocarcinoma were studied. From each patient two tissue samples were collected: one sample of the tumor and one sample of normal colorectal tissue from an area located 15 cm away from the tumor. Samples of colorectal mucosa obtained from 30 individuals without malignant disease were al... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676468 Sat, 02 Apr 2011 23:00:00 +0100 4676468 http://www.medworm.com/index.php?rid=4676470&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21461645%26dopt%3DAbstract Authors: Wei L, Zhao Y, Guo TK, Li PQ, Wu H, Xie HB, Ma KJ, Gao F, Xie XD The aim of present study was to evaluate the association of common polymorphisms detected in mitochondrial DNA (mtDNA) D-loop region (mononucleotide repetitive D310, single nucleotide polymorphism (SNP) D16521) with susceptibility to gastric cancer (GC) in northwestern Chinese population. A total of 180 GC patients and 218 healthy controls were investigated by using PCR- denaturing high performance liquid chromatography (DHPLC) assay. Genotype and allele distributions and haplotype construction were analyzed in case-control study. We found D310 and D16521 heteroplasmy were significantly different between GC cases and controls (p < 0.05), and D16521 homoplasmy showed association with histological grade of G... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676470 Fri, 01 Apr 2011 23:00:00 +0100 4676470 http://www.medworm.com/index.php?rid=4676469&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21461646%26dopt%3DAbstract Authors: Duzcan F, Duzcan SE, Sen S, Yorukoglu K, Caner V, Sen Turk N, Cetin GO, Kelten C, Tuna B, Sarsik B, Tepeli E The current study was undertaken to investigate chromosomal and genetical aberrations leading to overexpression of Topoisomerase-2α (TOP2α) and to reveal the possible association of these aberrations with HER2/neu overexpression and gene amplification, and to search for the relationship between TOP2α and HER2/neu status with prognostical biomarkers in papillary renal cell carcinoma (RCC), a group of tumors with diverse molecular, chromosomal and clinical features. Archival cases of papillary RCC obtained from Departments of Pathology of Pamukkale, Ege and Dokuz Eylul Universities were studied in two groups (type 1 and type 2) each containing 20 cases. The level of TO... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676469 Fri, 01 Apr 2011 23:00:00 +0100 4676469 http://www.medworm.com/index.php?rid=4676478&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21455631%26dopt%3DAbstract Authors: Liu DC, Yang ZL, Jiang S PEG10 is a transcriptional factor while TSG101 is involved in numerous cellular processes, including apoptotic resistance. Overexpression of PEG10 and TSG101 were observed in a variety of human cancers. However, their expression and clinical significance in gallbladder cancer (GBC) have not yet been identified. To understand the tumor biology of GBC at the molecular level, we examined PEG10 and TSG101 expression in 108 adenocarcinomas, 15 gallbladder polyps, 35 chronic cholecystitis tissues, and 46 peritumoral tissues by using immunohistochemistry. Overexpression of PEG10 and TSG101 was detected in gallbladder adenocarcinoma (48.1% and 47.2%, respectively). Conversely, there was less expression detected in the peritumoral tissues (19.6%), adenomatous p... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676478 Thu, 31 Mar 2011 23:00:00 +0100 4676478 http://www.medworm.com/index.php?rid=4676477&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21455632%26dopt%3DAbstract Authors: Szabó GV, Acsády G The development of the atherosclerosis is a multifactorial process, where the clinical pattern is determined by environmental and genetic factors. Except for the classical risk factors of atherosclerosis (hypertension, lipid-metabolic disorders, diabetes, smoking) the clinical signs can be influenced by the genetic variants (polymorphisms) of the enzymes, which are responsible for the endothelial cell function and for the thrombotic factors. In our examination our aim was to define the TNF-α 308GA polymorphisms in atherosclerotic diabetic, atherosclerotic non-diabetic and healthy patients. We found correlation of the frequency of myocardial infarction and stroke in atherosclerotic diabetic and atherosclerotic non-diabetic patients. We proved that among pa... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676477 Thu, 31 Mar 2011 23:00:00 +0100 4676477 http://www.medworm.com/index.php?rid=4676476&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21455633%26dopt%3DAbstract Authors: Naghibalhossaini F, Hosseini HM, Mokarram P, Zamani M Gene silencing due to DNA hypermethylation is a major mechanism for loss of tumor suppressor genes function in colorectal cancer. Activating V600E mutation in BRAF gene has been linked with widespread methylation of CpG islands in sporadic colorectal cancers. The aim of the present study was to evaluate the methylation status of three cancer-related genes, APC2, p14ARF, and ECAD in colorectal carcinogenesis and their association with the mutational status of BRAF and KRAS among Iranian colorectal cancer patients. DNA from 110 unselected series of sporadic colorectal cancer patients was examined for BRAF V600E mutation by PCR-RFLP. Promoter methylation of genes in tumors was determined by methylation specific PCR. The freque... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676476 Thu, 31 Mar 2011 23:00:00 +0100 4676476 http://www.medworm.com/index.php?rid=4676475&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21455634%26dopt%3DAbstract Authors: Kakihana K, Ohashi K, Hirashima Y, Murata Y, Kobayashi T, Yamashita T, Sakamaki H, Akiyama H We retrospectively analyzed the clinical outcomes of patients with pulmonary impairment before undergoing allogeneic hematopoietic stem cell transplantation (HSCT) for the first time. Among 297 evaluable patients who underwent their first HSCT, 23 had restrictive, obstructive or mixed ventilatory impairment (n = 9, 13 and 1, respectively). Males predominated among the patients with pulmonary impairment (p = 0.037) and received a reduced intensity conditioning (RIC) regimen more frequently, although the difference did not reach statistical significance (p = 0.05). Among 23 patients with pulmonary impairment, 9 underwent post-transplant pulmonary function tests and obstructiv... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676475 Thu, 31 Mar 2011 23:00:00 +0100 4676475 http://www.medworm.com/index.php?rid=4676474&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21455635%26dopt%3DAbstract We examined whether melanoma cells are sensitive to dexamethasone treatment. We have demonstrated for the first time that in human melanoma cell lines as well as in benign and malignant melanocytic tumors glucocorticoid receptor (GCR) is present both at mRNA and protein level. Dexamethasone applied at high doses inhibited the in vitro growth of WM983A human melanoma cells. The inhibitory effect was due to apoptosis induction. In the case of this relatively sensitive cell line dexamethasone enhanced the effect of the chemotherapeutic drug DTIC. PMID: 21455635 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676474 Thu, 31 Mar 2011 23:00:00 +0100 4676474 http://www.medworm.com/index.php?rid=4676473&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21455636%26dopt%3DAbstract Authors: Rijavec M, Silar M, Triller N, Kern I, Cegovnik U, Košnik M, Korošec P The aim of this study was to investigate the mRNA expression levels of multidrug resistance-associated proteins in chemo-naïve metastatic lung cancer cells and to determine the correlation with response to chemotherapy and overall survival. Metastatic cells were obtained by transbronchial fine needle aspiration biopsy of enlarged mediastinal lymph nodes in 14 patients with small cell lung cancer (SCLC) and 7 patients with non-small cell lung cancer (NSCLC). After cytological confirmation of lung cancer type, total RNA was extracted from biopsy samples and reverse transcribed to cDNA, and real-time PCR for the genes of interest [P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1), breast cancer r... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676473 Thu, 31 Mar 2011 23:00:00 +0100 4676473 http://www.medworm.com/index.php?rid=4676472&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21455637%26dopt%3DAbstract We examined the expression of tankyrase 1 by RT-PCR and Western blotting, and assessed telomerase activity by TRAP-ELISA method in gastric cancer and adjacent normal tissues. We found that tankyrase 1 expression was significantly up-regulated in gastric cancer tissues compared to normal corresponding tissues. Tankyrase 1 over-expression by gastric cancerous tissue was significantly associated with tumor histology differentiation and tumor stage. Moreover, tankyrase 1 expression was significantly correlation with telomerase activity. Our results indicate that tankyrase 1 over-expression may play an important role in gastric cancer development and progression. Tankyrase 1 may be used as a biomarker of gastric cancer and may serve as a target for cancer therapy. PMID: 21455637 [PubMed - a... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676472 Thu, 31 Mar 2011 23:00:00 +0100 4676472 http://www.medworm.com/index.php?rid=4676471&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21455638%26dopt%3DAbstract Authors: Pimentel-Nunes P, Afonso L, Lopes P, Roncon-Albuquerque R, Gonçalves N, Henrique R, Moreira-Dias L, Leite-Moreira AF, Dinis-Ribeiro M TLRs are important innate immunity receptors. Even though TLR2, 4 and 5 appear to be important for Helicobacter pylori (HP) recognition, their role in the evolution of gastritis to more advanced lesions is still unknown. To compare the expression of TLR2, 4 and 5 in normal gastric mucosa, HP+ gastritis, intestinal metaplasia, dysplasia and adenocarcinoma. Immunohistochemistry for TLR2, 4 and 5 was performed with anti-TLR2-TLR4-TLR5 antibodies in 117 histological samples of normal gastric mucosa (n = 22), HP+ gastritis (n = 20), intestinal metaplasia (n = 33), dysplasia (mucosectomy specimens, n = 20) and intestinal type adenocar... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676471 Thu, 31 Mar 2011 23:00:00 +0100 4676471 http://www.medworm.com/index.php?rid=4676479&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21448785%26dopt%3DAbstract Authors: Chu T, Chen X, Yu J, Xiao J, Fu Z Medulloblastoma (MB) is the most common embryonal CNS tumor of childhood. Its survival rates have significantly improved over the years due to developments in diagnostic techniques and therapeutic strategies. However, it is still an important cause of cancer-related deaths in children. Extracellular matrix metalloproteinase inducer (EMMPRIN) is a member of the immunoglobulin family and a glycoprotein enriched on the surface of many types of tumor cells. Therefore, the aim of this study was to investigate whether the expression patterns of EMMPRIN may predict the clinical prognosis in MB. EMMPRIN expression in a series of 56 MB with various grades and pathological types was analyzed by immunohistochemical staining on paraffin-embedded sections... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676479 Wed, 30 Mar 2011 23:00:00 +0100 4676479 http://www.medworm.com/index.php?rid=4676480&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21448784%26dopt%3DAbstract Authors: Giordano G, D'Adda T, Bottarelli L, Lombardi M, Brigati F, Berretta R, Merisio C Dedifferentiated carcinoma (DC) is an uterine neoplasm containing both low-grade endometrioid carcinoma (LGEC) and undifferentiated carcinoma (UC). DC is an aggressive tumour even when the UC component represents only 20% of the entire neoplasm. In this paper, two cases DCs at different stages of development, in 61- and 83-year-old women respectively were reported. In addition, in these uterine malignancies microsatellite instability (MSI) and loss of heterozygosity (LOH) were investigated in order to explain its aggressive behavior, in both components. Case #1 presented metastases at diagnosis, while case #2 was at a lower stage. LGEC component was invasive in case #1 and intramucous in case #2. ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676480 Tue, 29 Mar 2011 23:00:00 +0100 4676480 http://www.medworm.com/index.php?rid=4676481&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21424568%26dopt%3DAbstract Authors: Cui Q, Jiang W, Guo J, Liu C, Li D, Wang X, Zeng Y To investigate the relativity of MGMT(O-6-methylguanine-DNA methyltransferase) gene methylation from patients with protein expression and osteosarcoma necrosis rate after chemotherapy. Fifty-one oteosarcoma tissues were collected, Methylation of MGMT gene promoter was detected by methylation-specific PCR method, and protein expression of MGMT was examined by immunohistochemistry procedure, the relationship between methylated MGMT gene expression and patients response to chemotherapy was analyzed. The positive ratio of methylation MGMT gene promoter in 51 patients was 23.5% (12 in 51). Negative percentage of protein expression of MGMT was 27.5% (14 in 51). It seemed that methylation of MGMT gene in osteosarcoma tissues had no e... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4676481 Sun, 20 Mar 2011 00:00:00 +0100 4676481 http://www.medworm.com/index.php?rid=4555144&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21359685%26dopt%3DAbstract Authors: Fang Z, Xiong Y, Li J, Liu L, Li M, Zhang W, Shi L, Wan J The adenomatous polyposis coli (APC) gene has been shown to be involved in genetic instability and to be downregluated in several human carcinomas. The chromosome locus of APC, 5q21-22, is frequently deleted in colorectal cancers (CRCs). The functional impact of such regions needs to be extensively investigated in large amount of clinical samples. Case-matched tissues of CRC and adjacent normal epithelium (n = 134) were included in this study. Quantitative PCR was carried out to examine the copy number as well as mRNA expression of APC gene in colorectal malignancies. Our results showed that copy number deletions of APC were present in a relatively high percentage of colorectal cancer samples (26.1%, 35 out of 134).... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4555144 Sat, 26 Feb 2011 00:00:00 +0100 4555144 http://www.medworm.com/index.php?rid=4555145&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21336564%26dopt%3DAbstract Authors: Mise J, Dembitz V, Banfic H, Visnjic D A novel strategy has been suggested to enhance rapamycin-based cancer therapy through combining mammalian target of rapamycin (mTOR)-inhibitors with an inhibitor of the phosphatydilinositol 3-kinase PI3K/Akt or mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway. However, recent study demonstrated the potentiating effect of rapamycin on all-trans-retinoic acid (ATRA)-mediated differentiation of acute myelogenous leukemia (AML) cells, prompting us to investigate the effects of longitudinal inhibition of PI3K/Akt/mTOR signaling pathway on both proliferation and differentiative capacity of AML. In NB4, HL-60, U937 and K562 cell lines, rapamycin exerted minimal antiproliferative effects, and combining PI3... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4555145 Sat, 19 Feb 2011 00:00:00 +0100 4555145 http://www.medworm.com/index.php?rid=4500571&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21298377%26dopt%3DAbstract Authors: Li N, Wang J, Shen S, Bu X, Tian X, Huang P Surgical resection is the mainstay of treatment for colorectal carcinoma, however, the overall survival is modest due to frequent local recurrence from residual cancer cells after "curative" resection. Therefore, the status of surgical margin (tumor free or positive) has a significant influence on patient's survival. The difference in molecular profile between mucosa neighboring tumor lesions and remote area (surgical margin) may aid in evaluating resection status. 44 colorectal tumor tissues with corresponding adjacent non-neoplastic mucosa (within 3 cm from tumor tissues), and 110 tumor tissues with corresponding surgical margin mucosa (5 cm from tumor tissues) were randomly collected, fixed in 10% formalin and followed by embedd... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4500571 Sat, 05 Feb 2011 00:00:00 +0100 4500571 http://www.medworm.com/index.php?rid=4442318&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21279555%26dopt%3DAbstract Authors: Díaz Delgado M, Hernández Amate A, Pereira Gallardo S, Jaramillo S, Virizuela Echaburu JA, González-Cámpora RJ Recurrent or metastatic GISTs are currently treated with kinase inhibitors since they achieves disease control in 70-85% of patients but this response depend on KIT and PDGFRA gene mutation status. We review the morfological and molecular findings associated to kinase inhibitors administration in GISTs based on the literature on Medline and authors' own experience. The initial response to kinase inhibitors (imatinib mesylate, Gleevec, Novartis) usually is partial and depend on the mutational KIT or PDGFRA state. Amongst patients wih KIT mutations, the best results are achived in those harboring exon 11 (85%) and exon 9 (45%) mutations. GISTs harboring PDGFRA gene ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4442318 Sat, 29 Jan 2011 00:00:00 +0100 4442318 http://www.medworm.com/index.php?rid=4442321&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21274671%26dopt%3DAbstract The objective of this study was to investigate the presence of B-Raf mutations in sporadic BCCs as well as its correlation with the phenotype of microsatellite instability (MSI), the clinicopathological parameters of the tumours and p53 protein expression. 83 BCC specimens were screened for B-Raf mutations, applying polymerase chain reaction, single-stranded conformation polymorphism (PCR-SSCP) and DNA sequencing. MSI status was examined using mononucleotide microsatellite markers and p53 protein expression was demonstrated by immunohistochemical staining. A C to T transition at 1790 nucleotide leading to a silent mutation L597L; and a T to A transversion causing an amino acid change (F610I) have been found. MSI was detected in 5% of the cases and p53 accumulation was present in 37/83 sam... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4442321 Fri, 28 Jan 2011 00:00:00 +0100 4442321 http://www.medworm.com/index.php?rid=4442320&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21274672%26dopt%3DAbstract Authors: Méhes G, Hegyi K, Csonka T, Fazakas F, Kocsis Z, Radványi G, Vadnay I, Bagdi E, Krenács L Natural killer (NK) cells host in the human endometrium with dedicated role in reproductive physiology. Interestingly, malignant transformation of these specialized cells has not been presented thus far. Here we report a primary endometrial NK-cell lymphoma of a 48 year-old patient presenting with irregular bleeding. The endometrial curetting showed a dense lymphomatous infiltrate demonstrating highly infiltrative aggressive features with characteristic angiocentric, partially angiodestructive growth pattern and accompanying focal necroses. The lymphoma cells displayed a CD3ε/CD56/TIA-1/granzyme-B-positive and CD5/CD4/CD8/TCRγδ-negative immunophenotype, proved to be positive for Ep... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4442320 Fri, 28 Jan 2011 00:00:00 +0100 4442320 http://www.medworm.com/index.php?rid=4442319&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21274673%26dopt%3DAbstract Authors: Matsumoto N, Umezawa T, Sasaki T, Nakajima K, Kanetsuna Y, Sasaki H In the early stages of epithelial ovarian cancer, histopathological grading is important. However, the grading of ovarian clear cell carcinoma (OCCC) remains controversial. We aimed to identify irregular giant nuclear cells (IGNCs) by a simple method in clinical practice, and to evaluate the prognostic value of IGNCs in pT1 OCCC. Eighty-seven pT1 OCCC patients who underwent initial surgery at Jikei University Kashiwa Hospital, Chiba, Japan, were retrospectively assessed. Paraffin-embedded tissue sections (PTSs) stained with hematoxylin and eosin were reviewed. Giant nuclear cells (GNCs) were defined as cells with a nuclear length of more than twice the median nuclear length. GNCs with irregular nuclear circumf... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4442319 Fri, 28 Jan 2011 00:00:00 +0100 4442319 http://www.medworm.com/index.php?rid=4442325&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21267685%26dopt%3DAbstract Authors: Cserni G, Francz M, Kálmán E, Kelemen G, Komjáthy DC, Kovács I, Kulka J, Sarkadi L, Udvarhelyi N, Vass L, Vörös A Estrogen receptor (ER) testing has become an important part of breast cancer reporting as the ER status is a predictor of hormonal treatment efficacy. Progesteron receptors (PR) are often tested in parallel, and the best response to hormonal manipulations can be expected in tumors positive for both receptors. The existence of breast cancers with an ER negative and PR positive phenotype is controversial. A series of cases with this phenotype were reevaluated to clarify the existence and the frequency of this entity. A total of 205/6587 (3.1%; range of the rate per department: 0.3-7.1%.) cases reported to have the ER-negative and PR-positive status by immunohis... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4442325 Wed, 26 Jan 2011 00:00:00 +0100 4442325 http://www.medworm.com/index.php?rid=4442324&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21267686%26dopt%3DAbstract Authors: Lu L, Zhao G, Luu-The V, Ouellet J, Fan Z, Labrie F, Pelletier G Intratumoral biosynthesis of hormone steroids is thought to play a role in the pathogenesis and development of human breast cancer. There is evidence that glucocorticoids may inhibit the development and progression of breast cancer. 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 is the enzyme which converts inactive cortisone to active cortisol. In order to study the expression of 11β-HSD type 1 in breast cancer and non-cancerous breast tissue, we have developed specific antibodies to 11β-HSD type 1 and proceeded to localization of the enzyme in 84 specimens of breast carcinoma and adjacent non-malignant tissues by immnohistochemistry. The results were correlated with the expression of androgen receptor, e... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4442324 Wed, 26 Jan 2011 00:00:00 +0100 4442324 http://www.medworm.com/index.php?rid=4442323&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21267687%26dopt%3DAbstract In conclusion, CD99 expression and EWS/FLI1 translocation are specific and sensitive markers in the diagnosis of ESFTs. However, these were often not found in cases of cPNET. Therefore, in the diagnosis of ESFTs, clinical, radiological, histopathological and immunohistochemical parameters should always be evaluated together. PMID: 21267687 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4442323 Wed, 26 Jan 2011 00:00:00 +0100 4442323 http://www.medworm.com/index.php?rid=4442322&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21267688%26dopt%3DAbstract Authors: Tóth K, Galamb O, Spisák S, Wichmann B, Sipos F, Valcz G, Leiszter K, Molnár B, Tulassay Z Colorectal cancer is one of the leading death causes in the world. Specificity and sensitivity of the present screening methods are unsuitable and their compliance is too low. Nowadays the most effective method is the colonoscopy, because it gives not only macroscopic diagnosis but therapeutic possibility as well, however the compliance of the patients is very low. Hence development of new diagnostic methods is needed. Altered expression of septin 9 was found in several tumor types including colorectal cancer. The aim of this study was to detect the methylation related mRNA and protein expression changes of septin 9 in colorectal adenoma-dysplasia-carcinoma sequence and to analyze its... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4442322 Wed, 26 Jan 2011 00:00:00 +0100 4442322 http://www.medworm.com/index.php?rid=4442328&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21258883%26dopt%3DAbstract Authors: Golmoghaddam H, Pezeshki AM, Ghaderi A, Doroudchi M CD1 molecules might contribute to anti-tumor immune response by presentation of tumor-derived lipid and glycolipid antigens to T cells and NKT cells. Polymorphisms in CD1 genes have been suggested to modify ligand binding of CD1 molecules and thereby change the antigen presenting ability of these molecules. The aim of this study was to investigate the exon 2 polymorphisms of CD1a and CD1d in several high incident cancers in Iran. For this purpose, 201 female breast cancer patients and 207 healthy women, 64 lung cancer patients and 95 healthy individuals and 109 patients with colorectal cancer and 109 healthy controls were recruited to this study. Using PCR-SSP method, no significant correlation was found in genotype and allel... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4442328 Sat, 22 Jan 2011 00:00:00 +0100 4442328 http://www.medworm.com/index.php?rid=4442327&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21258884%26dopt%3DAbstract Authors: Deisch J, Raisanen J, Rakheja D SALL4 is a zinc finger transcription factor that plays a role in the maintainence and pluripotency of embryonic stem cell and is important in renal development where SALL4 mutations give rise to renal malformations. Because Wilms tumor recapitulates renal embryogenesis, we hypothesized that Wilms tumor cells may also express SALL4. We performed immunohistochemistry for SALL4 on tissue microarray sections of Wilms tumors, nephrogenic rests, and fetal renal cortices. Half (26 out of 52) of the Wilms tumors showed SALL4 immunoreactivity, ranging from strong and diffuse to focal and weak. Blastemal, epithelial, and combined blastemal and epithelial patterns of immunoreactivity were identified. No cases showed stromal staining. In the fetal kidney, S... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4442327 Sat, 22 Jan 2011 00:00:00 +0100 4442327 http://www.medworm.com/index.php?rid=4442326&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21258885%26dopt%3DAbstract We present a unique case of hypoglossal nerve invasion by ACC arising from the minor salivary glands in the tongue of a 34-year-old man. We also review and discuss current theories on the pathogenesis and mechanism of NI. PMID: 21258885 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4442326 Sat, 22 Jan 2011 00:00:00 +0100 4442326 http://www.medworm.com/index.php?rid=4442329&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21253919%26dopt%3DAbstract In this study, we examined associations of the MMP-7 plasma levels with clinical follow-up data in an independent cohort of bladder cancer patients to validate our former results and to assess if plasma is also suitable for MMP-7 analysis. Plasma levels of 97 patients and 22 controls were analyzed, using enzyme-linked immunosorbent assay. Associations between MMP-7 plasma concentrations and clinical data were assessed applying both univariate and multivariate analysis. Plasma MMP-7 levels were significantly higher in patients than in controls. Similarly to our former findings in sera, high MMP-7 plasma levels proved to be significant and independent predictors of both overall and disease-specific survival. In addition, we observed a metastasis-specific difference in MMP-7 levels between se... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4442329 Fri, 21 Jan 2011 00:00:00 +0100 4442329 http://www.medworm.com/index.php?rid=4378276&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21249485%26dopt%3DAbstract Authors: Beketic-Oreskovic L, Ozretic P, Rabbani ZN, Jackson IL, Sarcevic B, Levanat S, Maric P, Babic I, Vujaskovic Z The aim of this study was to examine the prognostic significance of carbonic anhydrase IX (CA-IX), an endogenous marker for tumor hypoxia; endoglin (CD105), a proliferation-associated and hypoxia-inducible glycoprotein and 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidative DNA lesion, in breast cancer patients. Immunohistochemical expressions of CA-IX, CD105 and 8-OHdG, analyzed on paraffin-embedded tumor tissues from forty female breast cancer patients, were used to assess their prognostic implication on overall survival (OS) and relapse-free survival (RFS). Patients with high CA-IX expression (above cut-off value) had a higher occurrence of relapse (P = 0.002). H... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378276 Thu, 20 Jan 2011 00:00:00 +0100 4378276 http://www.medworm.com/index.php?rid=4378278&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21240579%26dopt%3DAbstract This study underlines the accuracy conferred by homogenous LCM samples on gene expression profiles and confers further evidence regarding the role of ADAM12 and 17 in the breast tumorigenesis and progression. PMID: 21240579 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378278 Sun, 16 Jan 2011 00:00:00 +0100 4378278 http://www.medworm.com/index.php?rid=4378277&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21240663%26dopt%3DAbstract Authors: Chen AC, Waterboer T, Keleher A, Morrison B, Jindal S, McMillan D, Nicol D, Gardiner RA, McMillan NA, Antonsson A The aim of this study was to determine the prevalence of human papillomavirus (HPV) types in tissue and HPV antibodies in prostatic disease. Prostate tissue samples were collected from 51 patients diagnosed with adenocarcinoma and 11 with benign prostatic hyperplasia (BPH). All tissue samples were confirmed by histology. Plasma samples were available for 52 prostate patients. We investigated HPV DNA prevalence by PCR, and PCR positive samples were HPV type determined by sequencing. Prevalence of antibodies against twenty-seven HPV proteins from fourteen different HPV types was assessed in the plasma samples. The HPV DNA prevalence in the tissue samples was 14% (7/5... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378277 Sun, 16 Jan 2011 00:00:00 +0100 4378277 http://www.medworm.com/index.php?rid=4378280&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21234732%26dopt%3DAbstract This study is designed to gain more insight into the function of this fusion gene. We evaluated the whole genome expression in SYO-1 cells inhibited as a result of specific small interfering RNA for SYT-SSX. Cell proliferation and apoptosis were analyzed by flow cytometer and MTT. The proteins correlated with proliferation were also detected using western blot. TUNEL and Immunohistochemical stain assessment were also carried out on TMA of SS tissues. The mRNA level reduced over 90% caused by SYT-SSX specific siRNA. Five pathways were employed, that ERK1/2 pathway was differential significantly (p = 0.043218). Meanwhile, down-regulation of SYT-SSX fusion gene expression would inhibit the proliferation of SS cell and the survival rate decreased (34.1%), while apoptotic rate increased (10... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378280 Fri, 14 Jan 2011 00:00:00 +0100 4378280 http://www.medworm.com/index.php?rid=4378279&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21234733%26dopt%3DAbstract In this study, we aimed to investigate phospho-STAT5 (activated form of STAT5) expression and its relationship with the clinicopathological factors and overall survival of patients with colonic adenocarcinoma. A total of 121 histological samples were selected for this study. Immunohistochemistry was used to detect the expression of phospho-STAT5. Analysis of the immunohistochemical staining was based on the proportion of stained cells in the field: positive, >15% stained cells, and negative, <15% stained cells. Survival times were analyzed using the Kaplan-Meier method, and the differences between groups were assessed with the log-rank test. A multivariate Cox regression model was used for prognostic power analysis. Expression of phospho-STAT5 was observed in the cytoplasms of coloni... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378279 Fri, 14 Jan 2011 00:00:00 +0100 4378279 http://www.medworm.com/index.php?rid=4378281&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21229341%26dopt%3DAbstract Authors: Papachristou DJ, Goodman M, Cieply K, Rao UN PMID: 21229341 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378281 Thu, 13 Jan 2011 00:00:00 +0100 4378281 http://www.medworm.com/index.php?rid=4378284&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21221879%26dopt%3DAbstract Authors: Lakosi F, Antal G, Vandulek C, Kovacs A, Toller GL, Rakasz I, Bajzik G, Hadjiev J, Bogner P, Repa I The aim of our pilot study was to demonstrate the feasibility and dosimetric quality of MR-guided HDR prostate brachytherapy in a low-field 0.35T open MRI scanner and to present our initial clinical experiences. 16 patiets with intermediate- to high-risk localized prostate cancer were treated with 46-60 Gy of external beam radiotherapy preceded and/or followed by an 8 Gy MR-guided HDR boost. For interventions an MR compatible custom-made system, coaxial needles and plastic catheters were used. Template reconstruction, trajectory planning, image guidance, contouring and treatment planning were exclusively based on MR images. For treatment planning, dose-point- and anatomy-based... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378284 Tue, 11 Jan 2011 00:00:00 +0100 4378284 http://www.medworm.com/index.php?rid=4378282&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21222246%26dopt%3DAbstract We present a case of giant bilateral symptomatic adrenal myelolipomas associated with congenital adrenal hyperplasia. A 34 year old female, with congenital adrenal hyperplasia because of 21-hydroxylase deficiency, presented with diffuse abdominal pain and vomiting. Physical examination revealed hirsutism, pronounced virilization and palpable masses both on the right and left abdominal area. The abdominal CT demonstrated bilateral large masses in the anatomical position of the adrenal glands with densities indicating adipose tissue. The differential diagnosis was between myelolipoma and liposarcoma. For diagnostic and also therapeutical reasons, as the masses were large and symptomatic and causing pressure to the surrounding structures, the patient was submitted to laparotomy for bilateral... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378282 Tue, 11 Jan 2011 00:00:00 +0100 4378282 http://www.medworm.com/index.php?rid=4378288&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21221875%26dopt%3DAbstract We examined 102 paired normal and ovarian cancer samples for allelic loss in Parkin gene locus using Parkin gene associated microsatellite markers through loss of heterozygosity and changes in its expression through semiquantitative RT-PCR. Loss of heterozygosity identified common region of loss in Parkin locus with highest frequency for the intragenic marker D6S1599 (53%) whereas, 49 of 102 (48%) specimens showed decreased or no expression of Parkin in ovarian tumors. The study revealed that presence of loss of heterozygosity was significantly higher in both the intragenic markers (D6S1599 and D6S305) as compared with the locus of flanking region (D6S1008) with their p value 0.000001 and 0.00008, respectively. It also revealed that Parkin inactivation is probably a combination of loss of ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378288 Mon, 10 Jan 2011 00:00:00 +0100 4378288 http://www.medworm.com/index.php?rid=4378289&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21221874%26dopt%3DAbstract Authors: Sikalidis AK, Varamini B Colon cancer represents a highly prevalent disease in the Western world. While dietary and lifestyle recommendations remain important factors in disease prevention and treatment, epidemiological data have made it clear that obesity and excess body weight remain significant risk factors for the disease. A number of potential direct and indirect relationships exist between obesity and increased risk of colon cancer. Several mechanisms which appear promising and warrant further investigation are discussed here, specifically the modifying role of insulin and insulin-like growth factors, leptin, adipose-tissue induced changes in estrogens and androgens, and inflammatory molecules. A brief review of these hormones and signaling molecules and their action in ... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378289 Sun, 09 Jan 2011 00:00:00 +0100 4378289 http://www.medworm.com/index.php?rid=4378287&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21221876%26dopt%3DAbstract CONCLUSIONS: With the effective, neoadjuvant chemotherapy and comprehensive treatment, salvage treatment is not the contraindication of the patients with pathological fractures of combined primary osteosarcoma, and the treatment with long-term follow-up effectively. PMID: 21221876 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378287 Sun, 09 Jan 2011 00:00:00 +0100 4378287 http://www.medworm.com/index.php?rid=4378285&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21221878%26dopt%3DAbstract In this study, whether NDRG1 expression was correlated with differentiation of human breast cancer cells has been investigated. Endogenous expression level of NDRG1 was closely correlated with differentiation status of breast cancer cell lines. Furthermore, sodium butyrate (NaB), an inducer of cellular differentiation, increased the expression of β-casein, a milk-related differentiation marker, together with up-regulation of NDRG1 in breast cancer cells. In contrast, inhibition of NDRG1 by its siRNA resulted in reduced accumulation of β-casein. Immunohistochemical analysis showed co-expression of NDRG1 and β-casein or milk fat protein (MFP), another differentiation marker of breast tissue, in the mouse xenograft model of breast cancer. Furthermore, overexpression of NDRG1 expanded the d... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378285 Sun, 09 Jan 2011 00:00:00 +0100 4378285 http://www.medworm.com/index.php?rid=4378290&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21221873%26dopt%3DAbstract Authors: Chen CJ, Hsu HT, Lin MT, Pintye M, Chen JR PMID: 21221873 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research) Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378290 Sat, 08 Jan 2011 00:00:00 +0100 4378290 http://www.medworm.com/index.php?rid=4378286&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21221877%26dopt%3DAbstract Authors: Li QL, Yang ZL, Liu JQ, Miao XY Recent studies have shown that both CDX2 and Hepatocyte antigen (Hep) are detected in different types of cancer and associated with clinical prognosis. However, fever studies have examined gallbladder cancer specimens, and little is known about the clinicopathological significance of both CDX2 and Hep expression in gallbladder adenocarcinomas. In present study, we examined the expression frequencies of CDX2 and Hepatocyte antigen (Hep), and explored their clinicopathologic significances in gallbladder adenocarcinoma. Immunohistochemistry was used to detect and compare the frequencies of CDX2 and Hep expression in 108 samples of gallbladder adenocarcinoma, 46 peri-tumor tissues and 35 chronic cholecystitis. The expression frequencies for CDX2 and... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378286 Sat, 08 Jan 2011 00:00:00 +0100 4378286 http://www.medworm.com/index.php?rid=4378283&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21221880%26dopt%3DAbstract Definition of the "Drug-Angiogenic-Activity-Index" that Allows the Quantification of the Positive and Negative Angiogenic Active Drugs: A Study Based on the Chorioallantoic Membrane Model. Pathol Oncol Res. 2011 Jan 8; Authors: Demir R, Peros G, Hohenberger W Since the introduction of the angiogenic therapy by Folkman et al. in the 1970'ies many antiangiogenic drugs were identified. Only few of them are still now in clinical use. Also the Vascular Endothelial Growth Factor (VEGF), the cytokine with the highest angiogenic activity, has been identified. Its antagonist, Bevacizumab, is produced and admitted for the angiogenic therapy in first line for metastatic colorectal cancer. When we look at preclinical studies, they fail of in vivo models that define the "Drug-AngiogenicActi... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378283 Sat, 08 Jan 2011 00:00:00 +0100 4378283 http://www.medworm.com/index.php?rid=4378292&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213128%26dopt%3DAbstract Authors: Ngow HA, Wan Khairina WM A 15 year-old adolescent was referred with 2 month history of worsening of breathlessness and haemoptysis. He also reported constitutional symptoms of fever, poor appetite and weight loss. The chest roentgenogram showed a massive right pleural effusion with apparent cardiomegaly. The cardiac silhouette over the right heart border was obliterated and the mediastinum was widened. Computed tomogram of the thorax showed a bulky heterogeneous mass in the right lung with extension to the heart. Subsequent CT guided lung biopsy revealed Primitive Neuroectodermal tumour (PNET). Here, we illustrate the clinical course of an aggressive pulmonary PNET with lethal cardiac metastasis. PMID: 21213128 [PubMed - as supplied by publisher] (Source: Pathology Oncol... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378292 Fri, 07 Jan 2011 00:00:00 +0100 4378292 http://www.medworm.com/index.php?rid=4378291&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21213129%26dopt%3DAbstract Authors: Kim NS, Kang YJ, Jo JO, Kim HY, Oh YR, Kim YO, Jung MH, Ock MS, Cha HJ Recent studies have shown that thymosin β4 (TB-4) is highly related with tumor metastasis and angiogenesis. In addition, TB-4 induced the expression of VEGF in melanoma cells. We investigated the expression patterns of TB-4 and related angiogenic proteins, VEGF, and HIF-1α, at various stages of cervical cancers and also identified the expression pattern of these proteins in metastatic cervical cancers. Expression patterns of TB-4, VEGF, and HIF-1α were studied with tissue microarray containing 42 samples of cervical cancers. In addition, 15 cervical cancers and metastatic tumors in lymph nodes from patients who have metastatic tumors were also analyzed to confirm the role of TB-4, VEGF, and HIF -1α in c... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378291 Fri, 07 Jan 2011 00:00:00 +0100 4378291 http://www.medworm.com/index.php?rid=4378295&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21207255%26dopt%3DAbstract In this study we have described the expression of ERα, detected by immunocytochemistry in 11 ovarian carcinoma cell lines and by immunohistochemistry in 43 Federation Internationale des Gyneacologistes et Obstetristes stage III ovarian carcinoma specimens prepared before and after treatment with cisplatin-based schemes. For cisplatin resistance is a major obstacle in the treatment of ovarian carcinoma, analysis of cisplatin sensitivity in 11 ovarian carcinoma cell line was also performed. The strong nuclear ERα expression was only shown in the single A2780P cell line. Expression of ERα in tissue specimens did not reveal any correlations between histopathological parameters (histologic type and grading). We demonstrated a significant association with ERα expression in specimens from pri... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378295 Thu, 06 Jan 2011 00:00:00 +0100 4378295 http://www.medworm.com/index.php?rid=4378294&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21207256%26dopt%3DAbstract Authors: Kadivar M, Monabati A, Joulaee A, Hosseini N Controversies regarding the role of Epstein-Barr virus (EBV) in breast cancer and lack of published literature in this regard in Iran, prompted us to assess EBV presence in 100 breast carcinoma and 42 control biopsies obtained from Iranian women. Breast carcinoma cases were comprised of 81 invasive ductal carcinoma NOS, 9 invasive lobular carcinoma, 1 apocrine carcinoma, 2 cribriform carcinoma, 2 papillary carcinoma and 5 mucinous carcinoma. Control biopsies consisted of 13 fibroadenoma, 9 benign epithelial proliferation (adenosis and sclerosing adenosis), 9 usual ductal hyperplasia, 4 atypical ductal hyperplasia, 4 non-proliferative fibrocystic changes and 3 normal breast tissue. To identify EBV-infected cells we applied immunohist... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378294 Thu, 06 Jan 2011 00:00:00 +0100 4378294 http://www.medworm.com/index.php?rid=4378293&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21210262%26dopt%3DAbstract Authors: Yang L, Bian Y, Huang S, Ma X, Zhang C, Su X, Chen ZJ, Xie J, Zhang H The hedgehog signaling pathway plays an important role in cell growth and differentiation both in normal embryonic development and in tumors. Our previous work shows that hedgehog pathway is frequently activated in esophageal cancers. To further elucidate the role of hedgehog pathway in esophageal cancers we examined the expression of the target genes, hedgehog-interacting protein (HIP) and platelet derived growth factor receptor alpha (PDGFRα) and hedgehog signaling molecules, smoothened (SMO), suppressor of fused (Su(Fu)) in the specimens using in-situ hybridization and RT-PCR. We found that HIP, PDGFRα, SMO and Su(Fu) gene highly expressed in the primary esophageal squamous cell carcinomas but not in no... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378293 Thu, 06 Jan 2011 00:00:00 +0100 4378293 http://www.medworm.com/index.php?rid=4378297&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21203906%26dopt%3DAbstract Authors: Iyengar B, Singh AV The relationship of vasculogenic mimicry to pigment in nodular vertical growth phase [VGP] cutaneous melanomas is assessed in this study. 10 nodules each from 27 tumors, 15 pigmented and 12 amelanotic were sampled in proportion to the pigment level. Serial frozen and paraffin sections subjected to HE, Reticulin, PAS to assess the vascular pattern; Dopa Oxidase and Immunopositivity for HMB45, LN5 [laminin 5] & integrin[α(5)β(1)], and EM [electron microscopy] to identify Weibel-Palade bodies within endothelial cells. The vascular pattern, pigment and the immunopositivity was mapped to assess the percentage VM [vasculogenic sinusoids] vs INC [incorporated microvasculature]. In pigmented melanomas, INC from pre-existing stromal vessels is predominant. Ame... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378297 Tue, 04 Jan 2011 00:00:00 +0100 4378297 http://www.medworm.com/index.php?rid=4378296&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21203907%26dopt%3DAbstract Authors: Fernández-Aceñero MJ, Córdova S, Manzarbeitia F, Medina C Small cell carcinoma of the bladder is an uncommon and rather aggressive bladder tumor, representing less than 1% of all vesical tumors. Small cell carcinoma of different organs has been shown to express markers of neuroendocrine differentiation, and also thyroid transcription factor 1 (TTF-1). TTF-1 is a transcription factor and its expression has been shown mainly in pulmonary small cell carcinomas and adenocarcinomas and in thyroid tumors. Although it was initially proposed as a useful marker to delineate the origin of metastatic adenocarcinomas from the lung, its expression is being increasingly reported in tumors from different origins. The goal of this review is to analyse the immunohistochemical profile of sma... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378296 Tue, 04 Jan 2011 00:00:00 +0100 4378296 http://www.medworm.com/index.php?rid=4378299&cid=s_28427_32_f&fid=28427&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Ftmpl%3DNoSidebarfile%26db%3DPubMed%26cmd%3DRetrieve%26list_uids%3D21197591%26dopt%3DAbstract We describe the case of a 30-year-old man complaining of acute pain in his right elbow, mild distal paraesthesias, and some motor deficiencies. He was discovered as having a small fusiform swelling of the median nerve. In view of its very small size, shape, and nonspecific MRI signal, it had initially suggested a benign lesion. The diagnosis of epithelioid MPNST was made only at the histopathological examination. This malignant neoplasm recurred locally fourteen months after surgery. In addition to describe the above very rare case, we have reviewed the literature on epithelioid MPNSTs clearly involving deep major nerve trunks. This case serves as a warning that, even in major nerve trunks, tiny lesions may in reality be early intraneural MPNSTs which, due to their deep location, must be t... Pathology Oncology Research journals http://www.medworm.com/rss/comments.php?id=4378299 Sat, 01 Jan 2011 00:00:00 +0100 4378299