MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Pediatric Allergy and Immunology' source. Wed, 08 Feb 2012 06:43:02 +0100 http://www.medworm.com/index.php?rid=5659202&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01234.x Discussion:  The prevalence of allergic diseases is high in Iceland among children and young individuals. Asthma and atopic eczema are very common in childhood, but decreases with age while the prevalence of rhinoconjunctivitis increases markedly. The very high and increasing prevalence of rhinoconjunctivitis among 15‐ to 21‐year‐old individuals is noteworthy. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5659202 Thu, 02 Feb 2012 05:00:00 +0100 5659202 http://www.medworm.com/index.php?rid=5659201&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01246.x To cite this article: Kusunoki T, Mukaida K, Morimoto T, Sakuma M, Yasumi T, Nishikomori R, Heike T. Birth order effect on childhood food allergy. Pediatric Allergy Immunology 2012: DOI: 10.1111/j.1399‐3038.2011.01246.x.AbstractHigher birth order is associated with a smaller risk of allergy (birth order effect). The purpose of this study was to compare the significance of the birth order effect on the prevalence of specific allergic diseases [bronchial asthma (BA), atopic dermatitis (AD), allergic rhinitis (AR), allergic conjunctivitis (AC), and food allergy (FA)] among schoolchildren. A questionnaire survey dealing with the prevalence of allergic diseases was administered to the parents of 14,669 schoolchildren aged 7–15 yr. Based on the data, the prevalence of each allergic disease... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5659201 Thu, 02 Feb 2012 05:00:00 +0100 5659201 http://www.medworm.com/index.php?rid=5659200&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01258.x Conclusion:  Here, we provide the first direct evidence, derived from intervention, that components of the early‐life environment present on farms profoundly affects both local development of regulatory components of the mucosal immune system and immune responses to food proteins at weaning. We propose that neonatal piglets provide a tractable model which allows maternal and treatment effects to be statistically separated. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5659200 Thu, 02 Feb 2012 05:00:00 +0100 5659200 http://www.medworm.com/index.php?rid=5659199&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01257.x To cite this article: Rancière F, Clarisse B, Nikasinovic L, Just J, Momas I. Cough and dyspnoea may discriminate allergic and infectious respiratory phenotypes in infancy. Pediatr Allergy Immunol 2012: doi: 10.1111/j.1399‐3038.2011.01257.x.AbstractAsthma symptoms are non‐specific during infancy, making the identification of different subgroups among preschool children with early respiratory manifestations an important challenge. We previously used a clustering approach to identify bronchial obstructive phenotypes in 1‐yr‐old infants from the Pollution and Asthma Risk: an Infant Study (PARIS) birth cohort. In the present study, we examined whether these phenotypes were stable at 3 yr and studied their comorbidity and risk factors. Partitioning around medoids (PAM) method was app... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5659199 Thu, 02 Feb 2012 05:00:00 +0100 5659199 http://www.medworm.com/index.php?rid=5659198&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01259.x To cite this article: Diesner SC, Förster‐Waldl E, Olivera A, Pollak A, Jensen‐Jarolim E, Untersmayr E. Perspectives on immunomodulation early in life. Pediatric Allergy Immunology 2012: doi: 10.1111/j.1399‐3038.2011.01259.x.AbstractThe immune system early in life is characterized by immature activation and function of immune cells and a preponderance of Th2 cytokines. Together with other factors such as genetics and epigenetics, these immature immune responses might prone newborns susceptible to severe infections as well as allergic diseases. Immunomodulation therapy may have potential as therapeutic strategy against those disorders and might have implication in early‐life interventions in the future. In this review, we will focus on two immunomodulatory substance classes, Toll�... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5659198 Wed, 01 Feb 2012 05:00:00 +0100 5659198 http://www.medworm.com/index.php?rid=5637796&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2012.01271.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5637796 Sun, 29 Jan 2012 11:09:13 +0100 5637796 http://www.medworm.com/index.php?rid=5637795&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01231.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5637795 Sun, 29 Jan 2012 11:09:11 +0100 5637795 http://www.medworm.com/index.php?rid=5637794&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01215.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5637794 Sun, 29 Jan 2012 11:09:09 +0100 5637794 http://www.medworm.com/index.php?rid=5637793&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01146.x In this study, using a mouse model, we determined whether vitamin D deficiency in utero and during early life modulated the severity of asthma. Using dietary restriction, vitamin D3‐replete and vitamin D3‐deficient colonies of BALB/c mice were established. Utilizing the allergic airway disease model of asthma with the experimental allergen ovalbumin (OVA), we examined asthma‐like responses 24 h after airway challenge with OVA in adult offspring born to vitamin D3‐replete and vitamin D3‐deficient mothers. The ability of airway‐draining lymph node cells to proliferate and secrete cytokines in response to OVA ex vivo was significantly enhanced by vitamin D3 deficiency. However, other aspects of allergic disease, including the numbers and proportions of inflammatory cells and cyt... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5637793 Sun, 29 Jan 2012 11:09:05 +0100 5637793 http://www.medworm.com/index.php?rid=5637792&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01256.x To cite this article: Del Giacco SR, Carlsen K‐H, Du Toit G. Allergy and sports in children. Pediatric Allergy Immunol 2012: 23: 11–20.AbstractPhysical activity is beneficial for children with positive outcomes for mental and physical well‐being. Allergic conditions unique to the sporting arena may serve as an impediment to participation in physical activity for allergic children. A common example is exercise‐induced asthma; less common activity‐related allergic conditions include food‐dependent exercise‐induced anaphylaxis, exercise‐induced anaphylaxis, and exercise‐induced urticaria. Allergic children may also be at risk of allergic reactions when exposed to allergens that are more commonly found in the sports environment, e.g., latex, sports drinks, and medications suc... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5637792 Sun, 29 Jan 2012 11:08:48 +0100 5637792 http://www.medworm.com/index.php?rid=5637791&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01245.x To cite this article: Van Bever HPS, Lee BW, Shek L. Viewpoint: The future of research in pediatric allergy: What should the focus be? Pediatric Allergy Immunology 2012: 23: 5–10.AbstractAllergic diseases have been increasing during the last three decades, and exact reasons for this are still debated. Despite intense ongoing research, a lot of aspects of allergic diseases are still poorly understood, resulting in limitations in current therapeutic approach to allergies. In this viewpoint, important unanswered research questions are raised mainly on novel therapeutic approaches to allergic children, and suggestions for future research are raised. Three aspects of pediatric allergy are distinguished: the prevention, control, and cure. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5637791 Sun, 29 Jan 2012 11:08:46 +0100 5637791 http://www.medworm.com/index.php?rid=5637790&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2012.01274.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5637790 Sun, 29 Jan 2012 11:08:44 +0100 5637790 http://www.medworm.com/index.php?rid=5637789&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01270.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5637789 Sun, 29 Jan 2012 11:08:42 +0100 5637789 http://www.medworm.com/index.php?rid=5537223&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01242.x Conclusions:  These findings do not support the hypothesis that living in a ‘western’ versus more traditional environment leads to poor induction or suppressive function of neonatal Treg. However, environmentally‐induced immuno‐regulation may potentially occur via alternative mechanisms in PNG newborns that should now be investigated further. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5537223 Fri, 23 Dec 2011 05:00:00 +0100 5537223 http://www.medworm.com/index.php?rid=5537222&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01244.x Conclusions:  We demonstrated that 5 yr old children with persistent wheeze already had elevated exhaled inflammatory markers at preschool age compared to never wheezers, indicating augmented airway inflammation in these children. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5537222 Fri, 23 Dec 2011 05:00:00 +0100 5537222 http://www.medworm.com/index.php?rid=5537221&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01248.x To cite this article: Flohr C, Nagel G, Weinmayr G, Kleiner A, Williams HC, Aït‐Khaled N, Strachan DP, the ISAAC Phase Two Study Group. Tuberculosis, bacillus Calmette–Guérin vaccination, and allergic disease: Findings from the International Study of Asthma and Allergies in Childhood Phase Two. Pediatric Allergy Immunology 2011: Doi: 10.1111/j.1399‐3038.2011.01248.x.AbstractSome have suggested a protective effect of tuberculosis (TB) infection on allergic disease risk, but few studies have examined the association between the two. We therefore investigated whether TB disease and bacillus Calmette–Guérin (BCG) vaccination in early life protect against allergic disease. Information on allergic disease symptoms, past TB disease, and BCG vaccination as well as potential confounding ... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5537221 Fri, 23 Dec 2011 05:00:00 +0100 5537221 http://www.medworm.com/index.php?rid=5537220&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01249.x To cite this article: Lou W, Wang C, Wang Y, Han D, Zhang L. Responses of CD4+CD25+Foxp3+ and IL‐10‐secreting type I T regulatory cells to cluster‐specific immunotherapy for allergic rhinitis in children. Pediatric Allergy Immunology 2011: doi: 10.1111/j.1399‐3038.2011.01249.x.AbstractWe investigated the effects of cluster specific immunotherapy (SIT) with Dermatophagoides pteronyssinus (Der p) on CD4+CD25+Foxp3+ Treg cells and IL‐10‐secreting type I T regulatory (Tr1) cells in Der p‐sensitized children with allergic rhinitis (AR). We performed a prospective randomized study involving 46 children (aged 8–13 yr), of whom 25 children received Der p‐SIT + pharmacotherapy and 21 received only pharmacotherapy, over a period of 1 yr. Prior to and at end of treatment, CD... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5537220 Fri, 23 Dec 2011 05:00:00 +0100 5537220 http://www.medworm.com/index.php?rid=5537219&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01251.x To cite this article: Sucharew H, Khoury JC, Rao M, Succop P, Bernstein D, Ryan PH, LeMasters G. Predicting allergic disease at age four using an atopy predisposition score at age two: the application of item response theory. Pediatr Allergy Immunol 2011: doi:. 10.1111/j.1399‐3038.2011.01251.xAbstractWhen defining allergic outcomes in epidemiology studies, results of the skin prick test (SPT) panel are often dichotomized as positive/negative or categorized based on the number of positive responses. Item response theory (IRT) models, however, may prove to be a better alternative with the ability to generate scores that account for both type and number of positive SPTs. IRT was applied to SPT responses administered to 537 children at age two to determine predictability of allergic disease ... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5537219 Fri, 23 Dec 2011 05:00:00 +0100 5537219 http://www.medworm.com/index.php?rid=5537218&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01254.x To cite this article: McBride D, Keil T, Grabenhenrich L, Dubakiene R, Drasutiene G, Fiocchi A, Dahdah L, Sprikkelman AB, Schoemaker AA, Roberts G, Grimshaw K, Kowalski ML, Stanczyk‐Przyluska A, Sigurdardottir S, Clausen M, Papadopoulos NG, Mitsias D, Rosenfeld L, Reche M, Pascual C, Reich A, Hourihane J, Wahn U, Mills ENC, Mackie A, Beyer K. The EuroPrevall birth cohort study on food allergy: baseline characteristics of 12,000 newborns and their families from nine European countries. Pediatric Allergy Immunology 2011: doi: 10.1111/j.1399‐3038.2011.01254.x.AbstractIt is unclear why some children develop food allergy. The EuroPrevall birth cohort was established to examine regional differences in the prevalence and risk factors of food allergy in European children using gold‐standard ... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5537218 Fri, 23 Dec 2011 05:00:00 +0100 5537218 http://www.medworm.com/index.php?rid=5475881&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01229.x Conclusion:  These findings point to the importance of harmonization of features of study design, including subject selection criteria and variable definitions, in resolving epidemiological controversies such as those surrounding the impact of breastfeeding on asthma and allergic sensitization. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5475881 Sun, 04 Dec 2011 05:00:00 +0100 5475881 http://www.medworm.com/index.php?rid=5475880&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01232.x Conclusion:  Consistency between GINA and C‐ACT is not as to be expected. Using only one method for determining the control level of asthma does not seem to be reliable and accurate. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5475880 Sun, 04 Dec 2011 05:00:00 +0100 5475880 http://www.medworm.com/index.php?rid=5475879&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01233.x Conclusion:  Basophil CD63 allergen–specific sensitivity seems to be a promising tool for monitoring protective immune response in honeybee VIT. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5475879 Sun, 04 Dec 2011 05:00:00 +0100 5475879 http://www.medworm.com/index.php?rid=5475878&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01235.x Conclusion:  The annual incidence rate of accidental exposure for children with peanut allergy is 12.5%. Children with a recent diagnosis and adolescents are at higher risk. Hence, education of allergic children and their families is crucial immediately after diagnosis and during adolescence. As many reactions were treated inappropriately, healthcare professionals require better education on anaphylaxis management. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5475878 Sun, 04 Dec 2011 05:00:00 +0100 5475878 http://www.medworm.com/index.php?rid=5475877&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01237.x To cite this article: Peters RL, Gurrin LC, Allen KJ. The predictive value of skin prick testing for challenge‐proven food allergy: A systematic review. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399‐3038.2011.01237.xAbstractImmunoglobulin E‐mediated (IgE) food allergy affects 6–8% of children, and the prevalence is believed to be increasing. The gold standard of food allergy diagnosis is oral food challenges (OFCs); however, they are resource‐consuming and potentially dangerous. Skin prick tests (SPTs) are able to detect the presence of allergen‐specific IgE antibodies (sensitization), but they have low specificity for clinically significant food allergy. To reduce the need for OFCs, it has been suggested that children forgo an OFC if their SPT wheal size exceeds a cutoff t... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5475877 Sun, 04 Dec 2011 05:00:00 +0100 5475877 http://www.medworm.com/index.php?rid=5537217&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01243.x Conclusion:  Our findings suggest that innate immune genes contribute to the pathogenesis of asthma and eczema, and that these diseases likely have different genetic determinants. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5537217 Thu, 01 Dec 2011 05:00:00 +0100 5537217 http://www.medworm.com/index.php?rid=5486149&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01223.x Conclusion:  The results showed that in atopic children and adolescents, increased bronchial NO output as well as J′awNO(TMAD) were associated with EIB, while alveolar NO concentration (but not CANO[TMAD]) correlated with the degree of obstruction in smaller airways induced by exercise challenge. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5486149 Thu, 01 Dec 2011 05:00:00 +0100 5486149 http://www.medworm.com/index.php?rid=5475876&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01239.x To cite this article: Ismail IH, Oppedisano F, Joseph SJ, Boyle RJ, Robins‐Browne RM, Tang MLK. Prenatal administration of Lactobacillus rhamnosus has no effect on the diversity of the early infant gut microbiota. Pediatric Allergy Immunology 2011: Doi: 10.1111/j.1399‐3038.2011.01239.xAbstractWe have recently shown that maternal administration of Lactobacillus rhamnosus GG (LGG) during late pregnancy can have beneficial effects on the early development of infant gut microbiota, promoting a bifidobacteria profile similar to that of a healthy breastfed infant. It is uncertain, however, whether such probiotic supplementation could influence the diversity of infant gut microbiota. We investigated the effect of pre‐natal LGG on gut microbial diversity in the early post‐natal period. Day... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5475876 Thu, 01 Dec 2011 05:00:00 +0100 5475876 http://www.medworm.com/index.php?rid=5456539&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01180.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5456539 Wed, 30 Nov 2011 23:42:00 +0100 5456539 http://www.medworm.com/index.php?rid=5456538&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01247.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5456538 Wed, 30 Nov 2011 23:41:59 +0100 5456538 http://www.medworm.com/index.php?rid=5456537&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01131.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5456537 Wed, 30 Nov 2011 23:41:57 +0100 5456537 http://www.medworm.com/index.php?rid=5456536&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01209.x Conclusion:  A significantly decreased level of IL‐21 was observed in children suffering with severe AD compared with controls, suggesting that IL‐21 may play a role in AD. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5456536 Wed, 30 Nov 2011 23:41:55 +0100 5456536 http://www.medworm.com/index.php?rid=5456535&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01208.x In conclusion, indoor VM and fungal DNA were commonly found in monitored European schools and adversely related to respiratory health. Schools should be routinely tested through both culturable and non‐culturable methods for global indoor molds’ evaluation. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5456535 Wed, 30 Nov 2011 23:41:50 +0100 5456535 http://www.medworm.com/index.php?rid=5456534&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01204.x To cite this article: Atanasković‐Marković M. Educational case series: β‐lactam allergy and cross‐reactivity. Pediatr Allergy Immunol 2011: 22: 770–775.AbstractPenicillins and cephalosporins are the most widely used antibiotics for the treatment of common infections, and they are the two main classes of β‐lactams. On the basis of the time of appearance of the reaction after drug intake and for diagnostic purposes, hypersensitivity reactions to β‐lactams have been classified as immediate or non‐immediate. The diagnostic evaluation of allergic reactions to β‐lactams has changed over the last decade, for several reasons. In many countries, major and minor determinants for skin testing are not available. In immediate allergic reactions, the sensitivity of skin testing is ... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5456534 Wed, 30 Nov 2011 23:41:34 +0100 5456534 http://www.medworm.com/index.php?rid=5456533&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01236.x To cite this article: Hoernes M, Seger R, Reichenbach J. Modern management of primary B‐cell immunodeficiencies. Pediatr Allergy Immunology 2011: 22: 758–769.AbstractB‐cell defects constitute the majority of primary immunodeficiencies. Although a heterogeneous group of diseases, all are characterized by the reduction in or absence of immunoglobulins and/or specific antimicrobial antibodies. Substitution of immunoglobulin G (IgG) is therefore the mainstay of treatment. While from the late 1970s, the intravenous route of administration was the most common, in the past decades, subcutaneous immunoglobulin replacement therapy has become more popular among patients and physicians. Independently of the optimal route of administration, dosage and IgG trough level remain subjects of debate. ... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5456533 Wed, 30 Nov 2011 23:41:32 +0100 5456533 http://www.medworm.com/index.php?rid=5456532&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01238.x To cite this article: Skevaki CL, Maggina P, Santos AF, Alves RR, Antolin‐Amerigo D, Borrego LM, Bretschneider I, Butiene I, Couto M, Fassio F, Gardner J, Xatzipsalti M, 
Hovhannisyan L, Hox V, Makrinioti H, O’Neil SE, Pala G, Rudenko M, Santucci A, Seys S, Sokolowska M, Whitaker P, Heffler E. The 10th anniversary of the Junior Members and Affiliates of the European Academy of Allergy and Clinical Immunology. Pediatric Allergy Immunology 2011: 22: 754–757.AbstractThis year is the 10th anniversary of the European Academy of Allergy and Clinical Immunology (EAACI) Junior Members and Affiliates (JMAs). The aim of this review is to highlight the work and activities of EAACI JMAs. To this end, we have summarized all the initiatives taken by JMAs during the last 10 yr. EAACI JMAs are c... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5456532 Wed, 30 Nov 2011 23:41:30 +0100 5456532 http://www.medworm.com/index.php?rid=5456531&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01240.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5456531 Wed, 30 Nov 2011 23:41:29 +0100 5456531 http://www.medworm.com/index.php?rid=5440033&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01226.x Conclusion:  These results suggest that the children with asthma and food allergies have increased eosinophilic inflammation of the airways. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5440033 Tue, 22 Nov 2011 05:00:00 +0100 5440033 http://www.medworm.com/index.php?rid=5440032&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01227.x Conclusion:  Airway inflammation as measured by exhaled nitric oxide in young New Zealand children is related to their level of specific IgE to aeroallergens. This has implications for the utility of nitric oxide as a diagnostic and management tool in childhood asthma and for the importance of specific IgE as a marker of asthma severity. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5440032 Tue, 22 Nov 2011 05:00:00 +0100 5440032 http://www.medworm.com/index.php?rid=5440031&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01228.x Conclusion:  Despite this was not a study performed on a cohort of patients followed up from birth to adolescence, the molecular patterns of allergen recognition resulted modified according to age. These findings may support, at molecular level, the clinical features of the allergic march. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5440031 Tue, 22 Nov 2011 05:00:00 +0100 5440031 http://www.medworm.com/index.php?rid=5440030&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01230.x Conclusion:  Neonatal innate immune responses are differentially modulated by environmental exposure in the first month of life. The protective effect of breastfeeding against subsequent infections and atopy might be explained by its innate immune modulatory effects in the first month of life. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5440030 Tue, 01 Nov 2011 04:00:00 +0100 5440030 http://www.medworm.com/index.php?rid=5334700&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01224.x Conclusion:  WTVZV up to 8 yr of age protects against atopic disorders, which is likely mediated by suppression of IgE production and allergic sensitization, as well as altered leukocyte distributions. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5334700 Fri, 21 Oct 2011 22:41:06 +0100 5334700 http://www.medworm.com/index.php?rid=5334706&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01218.x Conclusions:  Secondary soy allergy may cause severe chronic besides acute symptoms. SPT with soy flour is a sensitive and specific tool in detecting soy sensitization. SPT with soy flour, CAP rGly m 4, and ISAC rGLY m 4 are valuable tools in the diagnosis of birch‐pollen‐associated secondary soy allergy. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5334706 Fri, 21 Oct 2011 04:00:00 +0100 5334706 http://www.medworm.com/index.php?rid=5334705&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01219.x Conclusions:  Sublingual immunotherapy with house dust mite allergen was not better than placebo in reducing rhinitis symptoms in house dust mite–allergic children in primary care. SLIT as administered in this study can be considered safe. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5334705 Fri, 21 Oct 2011 04:00:00 +0100 5334705 http://www.medworm.com/index.php?rid=5334704&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01220.x Conclusions:  Significant familial aggregation of specific response to allergen after adjustment for other atopy appears to reflect a genetic propensity toward atopy, dependent on shared familial exposures. Results also suggest that inheritance of asthma is independent of atopic sensitization. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5334704 Fri, 21 Oct 2011 04:00:00 +0100 5334704 http://www.medworm.com/index.php?rid=5334703&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01221.x Conclusions:  This study demonstrates that most paediatricians have read at least one anaphylaxis guideline. However, reading the guidelines does not seem to have influenced their daily practice. This suggests that there is a need for improved implementation of anaphylaxis guidelines amongst paediatricians. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5334703 Fri, 21 Oct 2011 04:00:00 +0100 5334703 http://www.medworm.com/index.php?rid=5334702&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01222.x Conclusion:  An interaction between tobacco smoke exposure and a CHRNA3/5 polymorphism was found for BHR in children, but CHRNA3/5 was not associated with asthma or lung function. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5334702 Fri, 21 Oct 2011 04:00:00 +0100 5334702 http://www.medworm.com/index.php?rid=5334701&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01225.x Conclusion:  These findings, in conjunction with earlier data, indicate that differences may exist in circulating concentrations of TARC and CTACK, between patients with atopic allergy and urticaria. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5334701 Fri, 21 Oct 2011 04:00:00 +0100 5334701 http://www.medworm.com/index.php?rid=5249925&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01184.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5249925 Sun, 25 Sep 2011 06:45:04 +0100 5249925 http://www.medworm.com/index.php?rid=5249924&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01211.x To cite this article: Nieto A, Mazon A, Martin‐Mateos MA, Plaza A‐M, Garde J, Alonso E, Martorell A, Boquete M, Lorente F, Ibero M, Bone J, Pamies R, Garcia JM, Echeverria L, Nevot S, Martinez‐Cañavate A, Fernandez‐Benitez M, Garcia‐Marcos L. Pediatric allergy and immunology in Spain. Pediatric Allergy Immunology 2011; 22: 742–750.AbstractThe data of the ISAAC project in Spain show a prevalence of childhood asthma ranging from 7.1% to 15.3%, with regional differences; a higher prevalence, 22.6% to 35.8%, is described for rhinitis, and atopic dermatitis is found in 4.1% to 7.6% of children. The prevalence of food allergy is 3%. All children in Spain have the right to be visited in the National Health System. The medical care at the primary level is provided by pediatricians, wh... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5249924 Sun, 25 Sep 2011 06:45:02 +0100 5249924 http://www.medworm.com/index.php?rid=5249922&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01160.x We examined the relationship of maternal total IgE obtained during pregnancy to the incidence of atopic dermatitis in their 2‐yr‐old offspring. Subjects were participants in an unselected Detroit area birth cohort. Serum IgE was measured from 458 mothers in the third trimester of pregnancy along with prenatal family and environmental histories. Children were evaluated at approximately 2 yr of age for current or past eczema by maternal questionnaire and physician examination. Among the 458 children, 20.3% (n = 93) had a doctor confirmed diagnosis of eczema. Prenatal IgE was higher among women whose children developed AD vs. women whose children did not [Geometric means and 95% confidence intervals 52.7 IU/ml (40.9–68.0) vs. 32.9 IU/ml (28.0–38.7), p = 0.010]. The assoc... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5249922 Sun, 25 Sep 2011 06:44:47 +0100 5249922 http://www.medworm.com/index.php?rid=5249920&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01164.x To cite this article: Yoshihara S, Kanno N, Fukuda H, Yamada Y, Fukuda N, Tsuchiya T, Arisaka O. Development and validation of a nighttime sleep diary in asthmatic children. Pediatric Allergy Immunology 2011; 22: 667–670.AbstractThe aim of this study was to derive a shorter version of the asthma diary, ‘a nighttime sleep diary’ from the traditional asthma diary (original version). The nighttime sleep diary mainly consisted of nighttime awakening that met the criteria of validity and practicality necessary for monitoring clinical control in infants and young children with asthma symptoms. Validation of the diary was performed in a 6‐week prospective study of 40 children aged 6 months to 6 years treated with nebulized budesonide inhalation suspension or cromolyn sodium nebulized ... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5249920 Sun, 25 Sep 2011 06:44:42 +0100 5249920 http://www.medworm.com/index.php?rid=5249919&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01162.x Conclusions:  We showed that Polish version of PAQLQ is valid and reliable among our study group. Moreover, as far as clinical practice is concerned, PAQLQ seems to be a useful tool for monitoring asthma in children especially based on the physician’s grading of asthma severity according to GINA guidelines. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5249919 Sun, 25 Sep 2011 06:44:40 +0100 5249919 http://www.medworm.com/index.php?rid=5249918&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01217.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5249918 Sun, 25 Sep 2011 06:44:37 +0100 5249918 http://www.medworm.com/index.php?rid=5249917&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01216.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5249917 Sun, 25 Sep 2011 06:44:35 +0100 5249917 http://www.medworm.com/index.php?rid=5236370&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01190.x Conclusions:  Our study contributes to the evidence that children with higher serum magnesium concentrations are less likely to have asthma. The associations between serum vitamin D concentrations and asthma were age‐dependent. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5236370 Mon, 19 Sep 2011 04:00:00 +0100 5236370 http://www.medworm.com/index.php?rid=5236369&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01191.x Conclusion:  Children allergic to peanuts with negative allergy tests to tree nuts had no co‐existing allergy, but were at risk of tree nut allergy where PTs were positive. Children with tree nut allergy were at risk of co‐existing peanut or other tree nut allergy whether PTs were positive or negative. Oral challenges to clarify allergy status in all nuts show co‐existing allergies even in young children and in so doing may reduce anxiety, minimize unnecessary dietary restrictions and prevent later episodes of anaphylaxis through uninformed exposure. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5236369 Mon, 19 Sep 2011 04:00:00 +0100 5236369 http://www.medworm.com/index.php?rid=5236368&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01194.x Conclusion:  Depression, as the consequence of psychosocial stress, may be a strong determinant of TGF‐β levels in breast milk. Seasonal and daily fluctuations in milk TGF‐β2 concentrations warrant further study. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5236368 Mon, 19 Sep 2011 04:00:00 +0100 5236368 http://www.medworm.com/index.php?rid=5236367&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01196.x Conclusion:  In grass pollen allergy, the continuous regimen performs better than the coseasonal in the first season, whereas in the subsequent years, the two regimens are nearly equivalent. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5236367 Mon, 19 Sep 2011 04:00:00 +0100 5236367 http://www.medworm.com/index.php?rid=5236366&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01198.x Conclusion:  The increased frequency of peripheral Th17 cells and serum IL‐17 levels are shown in childhood HSP that may in part contribute to vascular inflammation, suggesting cellular immunity is likely to be involved in the process of HSP. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5236366 Mon, 19 Sep 2011 04:00:00 +0100 5236366 http://www.medworm.com/index.php?rid=5236365&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01200.x Conclusions:  A clinical history of asthma and chronic/relapsing gastrointestinal symptoms (probably linked to food allergy) may predict the development of respiratory and gastrointestinal symptoms and the severity of anaphylaxis. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5236365 Mon, 19 Sep 2011 04:00:00 +0100 5236365 http://www.medworm.com/index.php?rid=5236364&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01201.x Conclusion: PCDH1 gene variant IVS3‐116 associates with eczema in two independent birth cohorts. Combined with previous observations, this indicates a shared genetic susceptibility to BHR, asthma and eczema. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5236364 Mon, 19 Sep 2011 04:00:00 +0100 5236364 http://www.medworm.com/index.php?rid=5236363&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01202.x Conclusion:  Maternal intake of FA during pregnancy was associated with childhood asthma. Maternal α‐linolenic acid, total n‐3 PUFA and palmitic acid intake may decrease, while arachidonic acid intake may increase the risk of asthma in the offspring. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5236363 Mon, 19 Sep 2011 04:00:00 +0100 5236363 http://www.medworm.com/index.php?rid=5236362&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01203.x Conclusions:  Phinf seems to be a reliable tool for predicting future sensitization as well as allergic symptoms in young children. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5236362 Mon, 19 Sep 2011 04:00:00 +0100 5236362 http://www.medworm.com/index.php?rid=5236361&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01204.x To cite this article: Atanasković‐Marković M. β‐lactam allergy and cross‐reactivity. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399‐3038.2011.01204.xAbstractPenicillins and cephalosporins are the most widely used antibiotics for the treatment of common infections, and they are the two main classes of β‐lactams. On the basis of the time of appearance of the reaction after drug intake and for diagnostic purposes, hypersensitivity reactions to β‐lactams have been classified as immediate or non‐immediate. The diagnostic evaluation of allergic reactions to β‐lactams has changed over the last decade, for several reasons. In many countries, major and minor determinants for skin testing are not available. In immediate allergic reactions, the sensitivity of skin testing is ... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5236361 Mon, 19 Sep 2011 04:00:00 +0100 5236361 http://www.medworm.com/index.php?rid=5236360&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01206.x Conclusions:  As in utero exposure to both UTI and PROM carry an increased risk of childhood asthma admission, this suggests that the immune system response generally is the relevant factor rather than a specific organism. The season‐associated risk is consistent with early pregnancy exposures such as the winter flu season or low vitamin D. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5236360 Mon, 19 Sep 2011 04:00:00 +0100 5236360 http://www.medworm.com/index.php?rid=5236359&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01205.x Conclusion:  These results show that partial WH with limited sensitizing properties reduced the effector response upon whey challenge. This effect is transferable using MLN cells and was associated with enhanced Foxp3+ regulatory T‐cell numbers in the MLN. Partial WH retained the capacity to induce active immune suppression in mice which may be relevant for allergy prevention. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5236359 Thu, 01 Sep 2011 04:00:00 +0100 5236359 http://www.medworm.com/index.php?rid=5224006&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01214.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5224006 Thu, 01 Sep 2011 04:00:00 +0100 5224006 http://www.medworm.com/index.php?rid=5224005&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01207.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5224005 Thu, 01 Sep 2011 04:00:00 +0100 5224005 http://www.medworm.com/index.php?rid=5224004&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01175.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5224004 Thu, 01 Sep 2011 04:00:00 +0100 5224004 http://www.medworm.com/index.php?rid=5224003&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01168.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5224003 Thu, 01 Sep 2011 04:00:00 +0100 5224003 http://www.medworm.com/index.php?rid=5224002&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01158.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5224002 Thu, 01 Sep 2011 04:00:00 +0100 5224002 http://www.medworm.com/index.php?rid=5224001&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01165.x This study assessed the quality of systematic reviews and meta‐analyses of sublingual immunotherapy (SLIT) for allergic rhinitis in children, published since 2000. Eligible reviews were identified by searching Medline/Pubmed, Embase, and the Cochrane Library, from 2000 through 2008. Methodological quality was assessed using the assessment of multiple systematic reviews instrument. Ten systematic reviews were included, one of which was published in the Cochrane Library. Eight reviews gave some details about the search strategy. None of the reviews included measures to avoid selection bias. In 60% of the reviews, the methodological quality of the included studies was (partly) assessed. Four reviews pooled the results of individual studies, neglecting clinical heterogeneity. Three of the 10... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5224001 Thu, 01 Sep 2011 04:00:00 +0100 5224001 http://www.medworm.com/index.php?rid=5224000&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01213.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5224000 Thu, 01 Sep 2011 04:00:00 +0100 5224000 http://www.medworm.com/index.php?rid=5223999&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01212.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5223999 Thu, 01 Sep 2011 04:00:00 +0100 5223999 http://www.medworm.com/index.php?rid=5223998&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01210.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5223998 Thu, 01 Sep 2011 04:00:00 +0100 5223998 http://www.medworm.com/index.php?rid=5078297&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01161.x Conclusions:  The morning serum ACTH level was found to be the most useful screening test to detect HPAS in this sample of children receiving ICS ± NS. A larger study should be undertaken to refine the diagnostic precision of the morning serum ACTH level. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5078297 Sat, 30 Jul 2011 13:52:08 +0100 5078297 http://www.medworm.com/index.php?rid=5052045&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01147.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5052045 Sat, 23 Jul 2011 13:52:52 +0100 5052045 http://www.medworm.com/index.php?rid=5052044&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01142.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5052044 Sat, 23 Jul 2011 13:52:51 +0100 5052044 http://www.medworm.com/index.php?rid=5052043&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01132.x In this study, the effect of supplementation of scGOS/lcFOS on the Ig‐fLC plasma concentrations in infants at risk for allergy was assessed. The plasma kappa and lambda Ig‐fLC concentrations were measured in a double‐blind, placebo‐controlled, randomized trial, in which infants at risk for developing allergic disease received a hypoallergenic whey formula containing 8 g/l of the scGOS/lcFOS mixture (n = 34) or maltodextrin as a placebo (n = 40) for 6 months. After intervention, plasma samples were collected, and total plasma concentrations of lambda and kappa Ig‐fLC were analyzed using ELISA. Total kappa and lambda Ig‐fLC plasma concentrations were higher in infants suffering from AD when compared to infants without any sign of AD. In infants receiving the prebiotic... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5052043 Sat, 23 Jul 2011 13:52:47 +0100 5052043 http://www.medworm.com/index.php?rid=5052042&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01096.x To cite this article: Furuhjelm C, Warstedt K, Fagerås M, Fälth‐Magnusson K, Larsson J, Fredriksson M, Duchén K. Allergic disease in infants up to 2 years of age in relation to plasma omega‐3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. Pediatr Allergy Immunol 2011; 22: 505–514.We have previously reported a protective effect of maternal omega‐3 long‐chain polyunsaturated fatty acids (ω‐3 LCPUFA) supplementation in pregnancy and lactation on IgE‐associated eczema and food allergy in the infant during the first year of life. Here we investigate whether the effects of the LCPUFA supplementation on IgE‐associated diseases last up to 2 yr of age and assess the relationship between plasma proportions of ω‐3 PUFAs and the frequency and s... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5052042 Sat, 23 Jul 2011 13:52:40 +0100 5052042 http://www.medworm.com/index.php?rid=5052041&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01117.x To cite this article: Audrain M, Martin J, Fromont P, Prié N, Thomas C, Muller J‐Y. Autoimmune neutropenia in children: analysis of 116 cases. Pediatr Allergy Immunol 2011; 22: 494–496.Diagnosis of autoimmune neutropenia (AIN) in infants is important, because it allows the exclusion of more severe forms of neutropenia that have an increased risk for leukemia. AIN is characterized by chronic neutropenia, which spontaneously resolves within several months to a few years, and mild infections. Diagnosis is confirmed by the presence of antibodies directed against neutrophil antigens. The human neutrophil antigen (HNA) system is a polymorphic system, which includes five antigen groups with different polymorphisms. In AIN, antibodies are mostly directed against HNA‐1 (or against a specific... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5052041 Sat, 23 Jul 2011 13:52:33 +0100 5052041 http://www.medworm.com/index.php?rid=5052040&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01121.x In conclusion, a considerable proportion of children and adolescents with asthma do not receive any asthma medication. Among those who do receive medication, adherence to current guidelines is questionable. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5052040 Sat, 23 Jul 2011 13:52:30 +0100 5052040 http://www.medworm.com/index.php?rid=5052039&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01197.x This article focuses on clinical utility through the prediction of cross‐reactivity or primary sensitization, estimation of the risk of reaction to heated food and the risk of severe clinical symptoms. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5052039 Sat, 23 Jul 2011 13:52:28 +0100 5052039 http://www.medworm.com/index.php?rid=5052038&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01199.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5052038 Sat, 23 Jul 2011 13:52:27 +0100 5052038 http://www.medworm.com/index.php?rid=5019702&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01186.x Conclusions:  Living in an Eastern vs. Western environment was associated with a different genetic profile associated with asthma and allergy in the Karelian populations. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5019702 Tue, 12 Jul 2011 23:00:00 +0100 5019702 http://www.medworm.com/index.php?rid=5019701&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01188.x Conclusion:  Congruence between current and long‐term asthma control was limited. Furthermore, we showed significant seasonal differences. It is therefore important to calculate asthma control over a longer period of time, instead of using current asthma control as indicator. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5019701 Tue, 12 Jul 2011 23:00:00 +0100 5019701 http://www.medworm.com/index.php?rid=5019700&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01189.x Conclusions:  Seafood allergy has a significant adverse effect on anxiety and stress in the families of affected children. Parental recall of dietary advice is variable and many tend to impose more stringent dietary avoidance than that recommended. Despite this, subsequent accidental reactions are common. Thus, the avoidance of seafood in children may be more difficult than often presumed. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5019700 Tue, 12 Jul 2011 23:00:00 +0100 5019700 http://www.medworm.com/index.php?rid=5019699&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01192.x Conclusion:  Other primary preventive asthma‐reducing interventions were shown to be effective in reducing the occurrence of asthma for at least the first 7–8 yr of life. The multifaceted PREVASC allergic asthma primary preventive intervention was effective in reducing the exposure to inhalant and food allergens, but was not feasible for the parents. A lack of sufficient room for improvement focus on stimulating adherence seemed to be involved. It is suggested that a multifaceted environmental exposure–reducing intervention may have to be adapted to the personal circumstances of patients at baseline. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5019699 Tue, 12 Jul 2011 23:00:00 +0100 5019699 http://www.medworm.com/index.php?rid=5019698&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01193.x Conclusion:  The proportion of symptomatic children without appropriate treatment was substantial throughout childhood, even when parents reported prolonged or severe symptoms. Treatment of asymptomatic children with inhaled corticosteroids increased with age and accounted for up to a third of all inhaled steroid use at 8 yr. These findings suggest that under and overtreatment of asthma in children was common. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5019698 Tue, 12 Jul 2011 23:00:00 +0100 5019698 http://www.medworm.com/index.php?rid=4903331&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01182.x Conclusions:  The product reduces symptoms of SAR in children and adolescents. Original data on pollen concentrations over 31 yr are presented with levels mainly in the low range favouring the observed efficacy profile. SMS communication on mobile phone for reminders and recording symptom scores was an excellent logistics tool. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4903331 Sun, 05 Jun 2011 23:00:00 +0100 4903331 http://www.medworm.com/index.php?rid=4903330&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01183.x To cite this article: Caubet J‐C, Pichler WJ, Eigenmann PA. Educational case series: Mechanisms of drug allergy. Pediatr Allergy Immunol 2011: Doi: 10.1111/j.1399‐3038.2011.01183.x.AbstractOnce administered, a drug can activate the immune system by various mechanisms and lead to a large range of clinical manifestations closely related to the type of immune reaction elicited. Administration of the drug can classically result in an immunoglobulin E (IgE)‐type sensitization, but can also result in more complex activation of the immune system potentially resulting in severe syndromes, such as the drug‐induced hypersensitivity syndrome (DIHS). Although there has been a major increase in our knowledge over the last years, the exact mechanisms of drug allergy are not well understood for m... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4903330 Sun, 05 Jun 2011 23:00:00 +0100 4903330 http://www.medworm.com/index.php?rid=5019697&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01195.x Conclusion:  Few and simple modifications in the design of epinephrine autoinjector were found effective in increasing its correct use and decreasing common use errors by untrained users. (Clinical trials identifier: NCT01217138). (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5019697 Tue, 31 May 2011 23:00:00 +0100 5019697 http://www.medworm.com/index.php?rid=5009211&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01166.x Conclusion:  Total serum tryptase levels are significantly higher in younger infants compared with older ones. In infants of the same age, serum tryptase levels may vary according to the clinical condition and thus suggest mast cell involvement in the physiologic as well as in the allergic immune responses of young infants. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=5009211 Tue, 31 May 2011 23:00:00 +0100 5009211 http://www.medworm.com/index.php?rid=4935705&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01181.x Conclusion:  The application of the anaphylaxis protocol substantially improved the physicians’ skills to manage this emergency in the PEU. Epinephrine administration showed no significant adverse effects. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4935705 Tue, 31 May 2011 23:00:00 +0100 4935705 http://www.medworm.com/index.php?rid=4903329&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01187.x Conclusion:  Osteoporosis appeared as an emerging health problem of patients with CVID, the risk increasing with older age and poorer lung function. Nutritional, biochemical, and immunologic factors appeared to take part in decreased BMD. Insight into the mechanisms of osteoporosis in CVID is crucial to develop preventive strategies. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4903329 Tue, 31 May 2011 23:00:00 +0100 4903329 http://www.medworm.com/index.php?rid=4789937&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01172.x Conclusion:  This study suggests a novel therapeutic effect of phCMF in treating infants with mild to moderate AD during the first 6 months of their life without affecting their nutritional status. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4789937 Fri, 06 May 2011 13:52:07 +0100 4789937 http://www.medworm.com/index.php?rid=4789941&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01163.x In conclusion, we identified several characteristics that may influence the development of FA in the next generation, including maternal AD and autumn birth. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4789941 Tue, 03 May 2011 23:00:00 +0100 4789941 http://www.medworm.com/index.php?rid=4789940&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01174.x Conclusions:  Serum levels of CCL18 correlate with the clinical severity score, serum eosinophil, and IgE levels. CCL18 is associated with AD and atopy. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4789940 Tue, 03 May 2011 23:00:00 +0100 4789940 http://www.medworm.com/index.php?rid=4789939&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01176.x Conclusion:  The maternal Western pattern during pregnancy may be preventive against wheeze in the offspring. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4789939 Tue, 03 May 2011 23:00:00 +0100 4789939 http://www.medworm.com/index.php?rid=4789938&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01177.x This study aimed to investigate whether AD in children could be better predicted by biologic markers (cord blood IgE [cbIgE], LT‐αNcoI alleles, and FcεRI‐β E237G genotypes) and maternal mentality during pregnancy, taking into account gender, socio‐demographic factors, and parental atopy. From 2001 to 2005, 1264 mother–infant pairs were recruited to participate in a birth cohort study. Prenatal questionnaire was used to collect family history, maternal gestational conditions and mentality, and environmental exposures. Cord blood was collected and assayed for genotypes and IgE levels. Phone interviews at 6 months and 2 yrs of age were conducted to inquire children’s health status, including AD occurrence. In addition to the known risk factors such as gender, maternal educati... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4789938 Tue, 03 May 2011 23:00:00 +0100 4789938 http://www.medworm.com/index.php?rid=4775997&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01148.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4775997 Tue, 03 May 2011 13:52:37 +0100 4775997 http://www.medworm.com/index.php?rid=4775996&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01118.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4775996 Tue, 03 May 2011 13:52:36 +0100 4775996 http://www.medworm.com/index.php?rid=4775995&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01179.x To cite this article: Celik G, Bakirtas A, Sackesen C, Reisli İ, Tuncer A. Pediatric allergy and immunology in Turkey. Pediatr Allergy Immunol 2011; 22: 440–448.AbstractAllergic diseases constitute a significant health problem in Turkey. According to a recent multicenter study, which used the ISAAC questionnaire, the mean prevalence of wheezing, rhinoconjunctivitis, and eczema in 10‐yr‐old school children during the past year was 15.8%, 23.5%, and 8.1%, respectively. A healthcare level system, regulated by Ministry of Health, is available in Turkey. Pediatric allergists and pediatric immunologists provide patient care at the tertiary level. Currently, 48 centers deliver care for allergic and immunologic diseases in children. There are 136 pediatric and 61 adult allergists/immunologi... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4775995 Tue, 03 May 2011 13:52:35 +0100 4775995 http://www.medworm.com/index.php?rid=4775994&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01116.x This study provides the first evidence that IL‐22 mRNA might be expressed in chronic severe asthmatic and AR children. The expression of IL‐22 and IL‐17A mRNAs in asymptomatic monosensitized seroatopic children suggests a role of these cytokines in the early events involved in the development of these allergic diseases. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4775994 Tue, 03 May 2011 13:52:32 +0100 4775994 http://www.medworm.com/index.php?rid=4775993&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01171.x In conclusion, we found an alarming under prescription of EAIs in school‐going adolescents. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4775993 Tue, 03 May 2011 13:52:28 +0100 4775993 http://www.medworm.com/index.php?rid=4775992&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01115.x To cite this article: Vetander M, Helander D, Lindquist C, Hedlin G, Alfvén T, Östblom E, Nilsson C, Lilja G, Wickman M. Classification of anaphylaxis and utility of the EAACI Taskforce position paper on Anaphylaxis in Children.Pediatric Allergy Immunology 2011;: 369–373.AbstractCorrect management and classification of anaphylaxis is mandatory. Records of emergency department (ED) visits to any of the three pediatric hospitals in Stockholm, because of reactions to foods during 2007, were identified. A retrospective analysis of clinical ED records of 371 children with 381 unique occasions of reactions to foods was performed. Symptoms/signs of reactions to foods recorded for classification of anaphylaxis were related to those presented in the EAACI Taskforce position paper on Anaphylaxis... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4775992 Tue, 03 May 2011 13:52:27 +0100 4775992 http://www.medworm.com/index.php?rid=4775991&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01170.x To cite this article: Jartti T, Korppi M. Rhinovirus‐induced bronchiolitis and asthma development. Pediatr Allergy Immunol 2011; 22: 350–355.AbstractHuman rhinovirus (HRV) and respiratory syncytial virus (RSV) are commonly associated with bronchiolitis. The breaking point in the dominance is approximately 12 months – rhinovirus dominates in the older children. Predisposition may markedly increase the prevalence of HRV bronchiolitis. Especially, low interferon responses and atopy‐related factors have been associated with HRV bronchiolitis. The former has been considered as a sign of poor antiviral defense, and the latter could be associated with atopic airway inflammation in wheezing children. Although recurrent wheezing is common after both RSV and HRV bronchiolitis, HRV bronchio... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4775991 Tue, 03 May 2011 13:52:25 +0100 4775991 http://www.medworm.com/index.php?rid=4775990&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01178.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4775990 Tue, 03 May 2011 13:52:24 +0100 4775990 http://www.medworm.com/index.php?rid=4685352&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01159.x Conclusions:  In Osaka Prefecture, Japan, the turning point when the prevalence of wheezing in schoolchildren had begun to increase was 1983. And the turning point when the increase in the prevalence of wheezing, atopic dermatitis, and non‐seasonal allergic rhinitis turned to decrease or constant was 1993. The prevalence of rhinitis and itching eyes in spring was still increasing in 2006. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4685352 Fri, 08 Apr 2011 13:52:06 +0100 4685352 http://www.medworm.com/index.php?rid=4685353&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01155.x Conclusion:  Our findings support the hypothesis of a link between maternal depression and infant’s wheezing and its severity early in life independent of allergic status. Consequences of our study include the need to assess depressive symptoms in mothers of infants with asthma. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4685353 Mon, 04 Apr 2011 23:00:00 +0100 4685353 http://www.medworm.com/index.php?rid=4671138&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01085.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4671138 Mon, 04 Apr 2011 13:52:34 +0100 4671138 http://www.medworm.com/index.php?rid=4671137&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01084.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4671137 Mon, 04 Apr 2011 13:52:33 +0100 4671137 http://www.medworm.com/index.php?rid=4671136&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01083.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4671136 Mon, 04 Apr 2011 13:52:33 +0100 4671136 http://www.medworm.com/index.php?rid=4671135&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01109.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4671135 Mon, 04 Apr 2011 13:52:32 +0100 4671135 http://www.medworm.com/index.php?rid=4671134&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01107.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4671134 Mon, 04 Apr 2011 13:52:32 +0100 4671134 http://www.medworm.com/index.php?rid=4671133&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01127.x In conclusion, fungal DNA and cat allergen contamination were common in schools from Malaysia and there was a high prevalence of respiratory symptoms among pupils. Moreover, there were associations between levels of some fungal DNA and reported respiratory health in the pupils. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4671133 Mon, 04 Apr 2011 13:52:28 +0100 4671133 http://www.medworm.com/index.php?rid=4671132&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01113.x To cite this article: Arvaniti F, Priftis KN, Papadimitriou A, Papadopoulos M, Roma E, Kapsokefalou M, Antracopoulos MB, Panagiotakos DB. Adherence to the Mediterranean type of diet is associated with lower prevalence of asthma symptoms, among 10–12 years old children: the PANACEA study. Pediatr Allergy Immunol 2011; 22: 283–289.Epidemiological studies have shown several associations between asthma symptoms and dietary factors. The aim of this work was to evaluate the relationship between adherence to the Mediterranean diet and childhood asthma. A cross‐sectional analysis was performed on 700 children (323 boys), 10–12 yr old, selected from 18 schools located in Athens greater area. Children and their parents completed questionnaires, which evaluated, among others, dietary habi... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4671132 Mon, 04 Apr 2011 13:52:27 +0100 4671132 http://www.medworm.com/index.php?rid=4671131&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01103.x To cite this article: Roy A, Downes MJ, Wisnivesky JP. Comprehensive environmental management of asthma and pediatric preventive care. Pediatr Allergy Immunol 2011; 22: 277–282.Indoor environmental triggers can increase asthma morbidity. National guidelines recommend comprehensive use of environmental control practices (ECPs) as a component of asthma management. The purpose of this study was to examine the association between preventive asthma care and comprehensive ECP use among children with asthma. We used data from the National Asthma Survey, including 1,921 children with asthma. Comprehensive use was defined as using at least five of eight ECPs: (i) air filter, (ii) dehumidifier, (iii) mattress cover, (iv) pillow cover, (v) pet avoidance, (vi) smoke avoidance, (vii) removing carpets... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4671131 Mon, 04 Apr 2011 13:52:26 +0100 4671131 http://www.medworm.com/index.php?rid=4671130&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01157.x To cite this article: Tozzi AE, Armenio L, Bernardini R, Boner A, Calvani M, Cardinale F, Cavagni G, Dondi A, Duse M, Fiocchi A, Marseglia GL, Miraglia del Giudice M, Muraro A, Pajno GB, Paravati F, Peroni D, Tripodi S, Ugazio AG, Indinnimeo L. Pediatric allergy and immunology in Italy. Pediatr Allergy Immunol 2011; 22: 267–276.AbstractIn Italy, according to the International Study on Asthma and Allergies in Childhood study, the prevalence of current asthma, allergic rhinoconjunctivitis, and atopic eczema in 2006 was 7.9%, 6.5%, and 10.1% among children aged 6–7 and 8.4%, 15.5%, and 7.75% among children aged 13–14 yr. University education in this field is provided by the Postgraduate Schools of Pediatrics and those of Allergology and Clinical Immunology, as well as several annual M... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4671130 Mon, 04 Apr 2011 13:52:24 +0100 4671130 http://www.medworm.com/index.php?rid=4671129&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01130.x To cite this article: Lack G, Caulfield H, Penagos M. The link between otitis media with effusion and allergy: a potential role for intranasal corticosteroids. Pediatr Allergy Immunol 2011; 22: 258–266.AbstractWe reviewed the evidence linking otitis media with effusion (OME) and atopy, with the goal of clarifying the possible role of intranasal corticosteroids (INSs) in OME treatment. In August 2009, the MEDLINE database was searched for primary studies on OME epidemiology, pathophysiology, and treatment. Relevant clinical guidelines were obtained. Interpreting OME research is complicated by variable disease definitions, patient populations, methodologies, and outcomes assessments, along with the possibility of spontaneous resolution. However, evidence links OME with atopic conditions in... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4671129 Mon, 04 Apr 2011 13:52:24 +0100 4671129 http://www.medworm.com/index.php?rid=4671128&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01156.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4671128 Mon, 04 Apr 2011 13:52:23 +0100 4671128 http://www.medworm.com/index.php?rid=4658910&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01169.x In conclusion, we confirm in numerous children that (i) only a few children with suspected betalactam hypersensitivity are allergic to betalactams; (ii) the likelihood of betalactam allergy increases with earliness and/or severity of the reactions; (iii) although non‐immediate‐reading skin tests (intradermal and patch tests) may diagnose non‐immediate sensitizations in children with non‐immediate reactions to betalactams (maculopapular rashes and potentially severe skin reactions especially), the diagnostic value of non‐immediate‐reading skin tests is far lower than the diagnostic value of immediate‐reading skin tests, most non‐immediate sensitizations to betalactams being diagnosed by means of challenge tests; (iv) cross‐reactivity and/or cosensitizations among betalacta... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4658910 Tue, 29 Mar 2011 23:00:00 +0100 4658910 http://www.medworm.com/index.php?rid=4643577&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01149.x Conclusion:  Kawasaki disease may be a risk factor for subsequent allergic diseases. We postulate that KD occurs more frequently in children at risk of immune disequilibrium, with an abnormal inflammatory response initially, and subsequently more allergic manifestations. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4643577 Sun, 27 Mar 2011 23:00:00 +0100 4643577 http://www.medworm.com/index.php?rid=4658909&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01167.x Conclusions:  Widely promulgated warning signs did not distinguish between patients with and without primary immunodeficiency. Likewise, primary immunodeficiency and allergy may coexist. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4658909 Tue, 01 Mar 2011 00:00:00 +0100 4658909 http://www.medworm.com/index.php?rid=4643576&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01126.x In this study, the genotype and phenotypes of three infants with OS from three unrelated Chinese families were investigated. All the three children had most of the characteristics of OS except normal serum IgE level. Compound heterozygosity mutations in RAG1 gene (1983 G>A; 2444 C>T and 2219 C>T; 3127 C>G) were identified in two cases, and a homozygous deletion mutation with a premature stop codon was found at residue 2302 of RAG1 gene (2302delT, I729X) in the remaining case, including three novel mutations (2302delT, I729X; 2219 C>T, R699W; and 3127 C>G, Y1001X). Spectratyping analysis of T‐cell receptor β‐chain variable region (TCRVβ) gene rearrangement was performed in case 1 and case 2. All the 25 TCRVβ subfamilies presented monoclonal or oligoclonal peaks in c... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4643576 Tue, 01 Mar 2011 00:00:00 +0100 4643576 http://www.medworm.com/index.php?rid=4606468&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01173.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4606468 Tue, 01 Mar 2011 00:00:00 +0100 4606468 http://www.medworm.com/index.php?rid=4593377&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01154.x To cite this article: Hompes S, Köhli A, Nemat K, Scherer K, Lange L, Rueff F, Rietschel E, Reese T, Szepfalusi Z, Schwerk N, Beyer K, Hawranek T, Niggemann B, Worm M. Provoking allergens and treatment of anaphylaxis in children and adolescents – data from the anaphylaxis registry of German‐speaking countries. Pediatr Allergy Immunol 2011: Doi: 10.1111/j.1399‐3038.2011.01154.x.AbstractAnaphylaxis is the most severe reaction of an IgE‐mediated hypersensitivity. Data about affected patients may help to improve our knowledge of anaphylaxis and its medical care. We analysed data from the anaphylaxis registry of German speaking countries with regard to the provoking allergens and treatment modalities of anaphylaxis in children and adolescents.Inclusion criteria were severe systemic all... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4593377 Tue, 01 Mar 2011 00:00:00 +0100 4593377 http://www.medworm.com/index.php?rid=4561177&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01153.x In conclusion, we found that previous and present allergic disease, heredity and male gender increased the risk of allergic rhinitis at 4½ yr of age. The introduction of fish before the age of 9 months reduced the risk. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4561177 Tue, 01 Mar 2011 00:00:00 +0100 4561177 http://www.medworm.com/index.php?rid=4513024&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01151.x Conclusions:  The significantly higher rates of food allergy in children born autumn/winter (compared to spring/summer), the relationship between relative food allergy rates and monthly UVR, combined with national adrenaline autoinjector and infant hypoallergenic formula prescription data, suggest that ultraviolet light exposure/vitamin D status may be one of many potential factors contributing to childhood food allergy pathogenesis. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4513024 Thu, 24 Feb 2011 14:52:05 +0100 4513024 http://www.medworm.com/index.php?rid=4502364&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01079.x To cite this article: Kukkonen AK, Kuitunen M, Savilahti E, Pelkonen A, Malmberg P, Mäkelä M. Airway inflammation in probiotic‐treated children at 5 years. Pediatr Allergy and Immunol 2011; 22: 249–251.Early treatment of new‐born high‐risk children with certain probiotic strains has reduced the risk of atopic eczema. Whether probiotics reduce risk for airway inflammation in long term is not known. We aimed at studying the effect of probiotic treatment during the six first months of life on airway inflammation at age 5 yr. In a randomized double‐blind allergy prevention trial between 2000 and 2007 in Helsinki, Finland, we gave a probiotic combination, plus pre‐biotics, or placebo, to 1018 children during 6 months from birth. At age 5, we measured exhaled nitric oxide (FE... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4502364 Tue, 22 Feb 2011 14:52:27 +0100 4502364 http://www.medworm.com/index.php?rid=4502363&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01094.x To cite this article: Kidon MI, Chin CW, Kang LW, Ching OT, Seng TY, Ning WK, Angus AC, Theng OS, Feng GY, Reginald K, Zhi BX, Shen SH & Tim CF. Mite component–specific IgE repertoire and phenotypes of allergic disease in childhood: The tropical perspective. Pediatr Allergy and Immunol 2011; 22: 202–210.Sensitization to perennial aeroallergens correlates with the risk of persistent asthma (AS) in children. In tropical Singapore, multiple codominant species of mites abound in the indoor environment, and preferential species‐specific sensitization has been associated with different phenotypes of allergic disease. We investigated the pattern of mite component–specific IgE (mcsIgE) in children with different phenotypes of clinical allergic disease in an environment with multiple mi... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4502363 Tue, 22 Feb 2011 14:52:24 +0100 4502363 http://www.medworm.com/index.php?rid=4502362&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01145.x To cite this article: Prescott S, Allen KJ. Food allergy: Riding the second wave of the allergy epidemic. Pediatr Allergy Immunol 2011; 22: 155–160.AbstractFood allergy is a substantial and evolving public health issue, recently emerging over the last 10–15 yr as a ‘second wave’ of the allergy epidemic. It remains unclear why this new phenomenon has lagged decades behind the ‘first wave’ of asthma, allergic rhinitis and inhalant sensitization. In regions like Australia, which lead the respiratory epidemic, challenge‐proven IgE‐mediated food allergy now affects up to 10% of infants. Although their parents were among the first generation to experience the large‐scale rise in allergic diseases, disorders of oral tolerance were previously uncommon. Of further concern, this ... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4502362 Tue, 22 Feb 2011 14:52:21 +0100 4502362 http://www.medworm.com/index.php?rid=4502356&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01144.x To cite this article: Chang C‐F, Wu FF‐S, Chen C‐Y, Crane J, Siebers R. Effect of freezing, hot tumble drying and washing with eucalyptus oil on house dust mites in soft toys. Pediatric Allergy Immunology 2011; Doi no: 10.1111/j.1399‐3038.2011.01144.x.AbstractSoft toys are a major source of house dust mites (HDM) and HDM allergens, and sleeping with soft toys is a significant risk factor for HDM sensitization. We studied three techniques to eliminate HDM from soft toys, namely freezing, hot tumble drying and washing with eucalyptus oil. Thirty‐six toys (12 in each treatment group) were enumerated for live HDM by the heat escape method before and after freezing overnight, hot tumble drying for 1 h and washing in 0.2% to 0.4% eucalyptus oil. Freezing, hot tumble drying and washin... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4502356 Mon, 21 Feb 2011 00:00:00 +0100 4502356 http://www.medworm.com/index.php?rid=4502361&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01096.x To cite this article: Furuhjelm C, Warstedt K, Fagerås M, Fälth‐Magnusson K, Larsson J, Fredriksson M, Duchén K. Allergic disease in infants up to 2 yr of age in relation to plasma omega‐3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. Pediatric Allergy and Immunology 2011; Doi no: 10.1111/j.1399‐3038.2010.01096.xWe have previously reported a protective effect of maternal omega‐3 long‐chain polyunsaturated fatty acids (ω‐3 LCPUFA) supplementation in pregnancy and lactation on IgE‐associated eczema and food allergy in the infant during the first year of life. Here we investigate whether the effects of the LCPUFA supplementation on IgE‐associated diseases last up to 2 yr of age and assess the relationship between plasma proportions of ω... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4502361 Sun, 20 Feb 2011 00:00:00 +0100 4502361 http://www.medworm.com/index.php?rid=4502360&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01102.x To cite this article: Zachariassen G, Faerk J, Esberg BH, Fenger‐Gron J, Mortensen S, Christesen HT, Halken S. Allergic diseases among very preterm infants according to nutrition after hospital discharge. Pediatric Allergy and Immunology 2011; Doi no: 10.1111/j.1399‐3038.2010.01102.xTo determine whether a cow’s milk‐based human milk fortifier (HMF) added to mother’s milk while breastfeeding or a cow’s milk‐based preterm formula compared to exclusively mother’s milk after hospital discharge, increases the incidence of developing allergic diseases among very preterm infants (VPI) during the first year of life.Of a cohort of 324 VPI (gestational age 24–32 wk), the exclusively breastfed VPI were shortly before discharge randomized to breastfeeding without fortification or s... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4502360 Sun, 20 Feb 2011 00:00:00 +0100 4502360 http://www.medworm.com/index.php?rid=4502359&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01106.x In conclusion, high levels of SIgA antibodies in sensitized infants were associated with significantly less late‐onset wheezing, supporting a protective role against development of asthmatic symptoms. Recurrent infections and other factors supporting an increased microbial pressure during infancy were associated with high levels of salivary SIgA. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4502359 Sun, 20 Feb 2011 00:00:00 +0100 4502359 http://www.medworm.com/index.php?rid=4502358&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01150.x Conclusions:  Environmental factors and therapy adherence were not associated with asthma control. In our cohort, uncontrolled asthma is associated with low maternal education and with strong parental beliefs about medication necessity and higher concern about potential side effects of medication. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4502358 Sun, 20 Feb 2011 00:00:00 +0100 4502358 http://www.medworm.com/index.php?rid=4502357&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01152.x Discussion:  Based on reports from experienced parents of food allergic children, newly diagnosed parents could benefit from a comprehensive FA management curriculum. Improving access to clear and concise educational materials would likely reduce stress/anxiety and improve quality of life. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4502357 Sun, 20 Feb 2011 00:00:00 +0100 4502357 http://www.medworm.com/index.php?rid=4477630&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01119.x To cite this article: Lam KP, Chu YT, Lee MS, Chen HN, Wang WL, Tok TS, Chin YY, Chen SC, Kuo CH, and Hung CH. Inhibitory Effects of Albuterol and Fenoterol on RANTES and IP‐10 Expression in Bronchial Epithelial Cells. Pediatric Allergy Immunology 2011.AbstractShort‐acting β2‐adrenoreceptor agonist (SABA) is the major asthma reliever as indicated in the GINA guidelines. Regulated on activation, normal T expressed and secreted (RANTES) is a chemokine that attracts eosinophils, mast cells, and basophils toward site of allergic inflammation. Interferon γ‐inducible protein (IP)‐10 is a Th1‐related chemokine that is also important in asthmatic inflammation and also involved in our immune defense against pathogens. Bronchial epithelial cells are first‐line barrier against invasiv... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4477630 Tue, 15 Feb 2011 00:00:00 +0100 4477630 http://www.medworm.com/index.php?rid=4460618&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01124.x To cite this article: Bunyavanich S, Shargorodsky J, Celedón JC. A meta‐analysis of Th2 pathway genetic variants and risk for allergic rhinitis. Pediatric Allergy Immunology 2011; DOI: 10.1111/j.1399‐3038.2010.01124.xAbstractThere is a significant genetic contribution to allergic rhinitis (AR). Genetic association studies for AR have been performed, but varying results make it challenging to decipher the overall potential effect of specific variants. The Th2 pathway plays an important role in the immunological development of AR. We performed meta‐analyses of genetic association studies of variants in Th2 pathway genes and AR. PubMed and Phenopedia were searched by double extraction for original studies on Th2 pathway‐related genetic polymorphisms and their associations with AR. A ... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4460618 Thu, 10 Feb 2011 00:00:00 +0100 4460618 http://www.medworm.com/index.php?rid=4460617&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01134.x Conclusion:  In childhood and adolescence, allergologic testing in cases of suspected drug hypersensitivity is of importance both to establish a correct diagnosis and to prevent unjustified withholding of a drug or class of drugs. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4460617 Thu, 10 Feb 2011 00:00:00 +0100 4460617 http://www.medworm.com/index.php?rid=4460616&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01143.x To cite this article: Arga M, Bakirtas A, Catal F, Derinoz O, Harmanci K, Razi CH, Ergöcen S, Demirsoy MS, Turktas I. Training of trainers on epinephrine autoinjector use. Pediatric Allergy Immunology 2011; Doi no: 10.1111/j.1399‐3038.2011.01143.x.AbstractThe majority of physicians do not know how to use epinephrine autoinjectors. This displays that current education of physicians on anaphylaxis is inadequate for a thorough practice. We hypothesize that a theoretical lecture together with a practical session on epinephrine autoinjector use will improve its proper use by physicians. Residents, specialists, and consultants from General Pediatrics excluding allergists and allergy fellows were included in this study. All physicians were given an eight‐item questionnaire followed by a prac... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4460616 Thu, 10 Feb 2011 00:00:00 +0100 4460616 http://www.medworm.com/index.php?rid=4442503&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01135.x Conclusion:  Our finding that combined pill use before pregnancy was not related to respiratory outcomes should provide reassurance to the vast majority of mothers using OCPs before becoming pregnant. The small association with progestin‐only pill use and early respiratory outcomes may reflect uncontrolled confounding or other bias. Nonetheless, it does suggest that these two types of pills should be examined separately in future analyses of respiratory and other childhood outcomes. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4442503 Mon, 07 Feb 2011 00:00:00 +0100 4442503 http://www.medworm.com/index.php?rid=4442502&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01133.x Conclusion:  Dietary DHA/AA supplementation leads to a significant amelioration of allergen‐induced dermatitis. This was accompanied with the presence of increased regulatory T cells and IL‐10 expression in lesional skin. Moreover, we identify keratinocytes, which play a crucial role in the regulation of skin inflammation, as important targets of DHA/AA supplementation. Future studies are needed to clarify whether DHA/AA acts directly or whether its biologic active metabolites are responsible for these findings. This may unravel novel therapeutical compounds for allergen‐induced dermatitis. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4442502 Mon, 07 Feb 2011 00:00:00 +0100 4442502 http://www.medworm.com/index.php?rid=4424782&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01136.x Conclusion:  In DKC, development of immunologic abnormalities can precede bone marrow failure, highlighting the importance of proper immunodeficiency management to minimize morbidity and premature mortality in this disease. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4424782 Tue, 01 Feb 2011 00:00:00 +0100 4424782 http://www.medworm.com/index.php?rid=4424781&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01125.x This study aimed to characterize β‐1,3‐glucanase and thaumatin‐like protein (TLP) as banana allergens, testing them, together with other plant food allergens, in 51 children with allergic reactions after banana ingestion and both positive specific IgE and skin prick test (SPT) to banana. Banana β‐1,3‐glucanase and TLP were isolated and characterized. Both banana allergens, together with kiwifruit TLP Act d 2, avocado class I chitinase Pers a 1, palm pollen profilin Pho d 2 and peach fruit lipid transfer protein (LTP) Pru p 3, were tested by in vitro and in vivo assays. Banana β‐1,3‐glucanase (Mus a 5) was glycosylated, whereas banana TLP (Mus a 4) was not, in contrast with its homologous kiwi allergen Act d 2. Specific IgE to both banana allergens, as well as to peach Pru ... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4424781 Tue, 01 Feb 2011 00:00:00 +0100 4424781 http://www.medworm.com/index.php?rid=4424780&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2011.01140.x Conclusions:  A large proportion of children are subjected to FA testing in their early years. This result shows the need to evaluate the financial burden of FA testing and to improve current testing practices. (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4424780 Tue, 01 Feb 2011 00:00:00 +0100 4424780 http://www.medworm.com/index.php?rid=4394331&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01100.x (Source: Pediatric Allergy and Immunology) Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4394331 Tue, 25 Jan 2011 15:14:31 +0100 4394331 http://www.medworm.com/index.php?rid=4394330&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01093.x To cite this article: Konstantinou GN, Papadopoulos NG, Tavladaki T, Tsekoura T, Tsilimigaki A, Grattan CEH. Childhood acute urticaria in northern and southern Europe shows a similar epidemiological pattern and significant meteorological influences. Pediatric Allergy Immunology 2011: 22: 36–42.AbstractAcute urticaria (AU) is a common condition that often presents in childhood. Although there is a general perception of cyclic annual trends in AU, no one has tried to identify any seasonal variation on its prevalence and incidence, associate environmental influences and impute geographic, ethnical, or even genetic features that may contribute to its onset. We aimed to analyze the influence of climate and geographic parameters on annual fluctuation of AU cases referred to the Emergency Depar... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4394330 Tue, 25 Jan 2011 15:14:24 +0100 4394330 http://www.medworm.com/index.php?rid=4394329&cid=s_33159_3_f&fid=33159&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-3038.2010.01120.x To cite this article: Church MK, Weller K, Stock P, Maurer M. Chronic spontaneous urticaria in children: Itching for insight. Pediatr Allergy Immunol 2011: 22: 1–8.AbstractWhile there is increasing information about the pathogenesis and treatment of chronic spontaneous urticaria (csU) in adults, there is little published information about csU in children. Consequently, most of the recommendations contained in current guidelines for the prevention and treatment of csU in infants and children is based on extrapolation of data obtained in adults. To rectify this, this review points out critical gaps in our knowledge and suggests strategies which may help us to improve our understanding of this condition. How common is csU in children? What do we know about its clinical presentation and the ... Pediatric Allergy and Immunology journals http://www.medworm.com/rss/comments.php?id=4394329 Tue, 25 Jan 2011 15:14:21 +0100 4394329