MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Pediatric Blood and Cancer' source. Wed, 08 Feb 2012 08:41:53 +0100 http://www.medworm.com/index.php?rid=5666782&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24080 ConclusionsIn Africa liver metastases do not appear to worsen the prognosis of children with Stage IV WT. Despite the poor socio‐economic circumstances survival is comparable to other countries. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5666782 Wed, 08 Feb 2012 12:57:11 +0100 5666782 http://www.medworm.com/index.php?rid=5666786&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24073 ConclusionsSCH 727965 shows an interesting pattern of activity suggesting its potential applicability against selected childhood cancers, particularly leukemias. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5666786 Tue, 07 Feb 2012 05:00:00 +0100 5666786 http://www.medworm.com/index.php?rid=5666785&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23381 AbstractHemophagocytic lymphohistiocytosis (HLH) is a systemic disease resulting from the excessive release of inflammatory cytokines by macrophages under prolonged antigenic stimulation. If untreated, it leads to multiorgan failure and death. Necrotizing enterocolitis (NEC) has not previously been associated with HLH. Here we report four preterm infants who were diagnosed with HLH associated with NEC. Two patients received chemotherapy and one survived. The other two infants succumbed to multiorgan failure. These results suggest that NEC may be a common clinical manifestation of HLH in premature neonates. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5666785 Tue, 07 Feb 2012 05:00:00 +0100 5666785 http://www.medworm.com/index.php?rid=5666784&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23391 AbstractArsenic trioxide was tested against the PPTP in vitro panel (1.0 nM to 10 µM) and against the PPTP Ewing sarcoma in vivo panel administered intraperitoneally at a dose of 2.5 mg/kg daily × 5 per week for a planned treatment duration of 3 weeks. Arsenic trioxide showed a median relative IC50 value of 0.9 µM, with Ewing sarcoma cell lines having IC50 values similar to those of the remaining PPTP cell lines. Arsenic trioxide did not induce significant differences in EFS distribution compared to control in any of the Ewing sarcoma xenografts studied, and no objective responses were observed. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5666784 Tue, 07 Feb 2012 05:00:00 +0100 5666784 http://www.medworm.com/index.php?rid=5666783&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24071 ConclusionsBrief, focused training in pediatric cancer histopathology can improve diagnostic accuracy. Dynamic and static telepathology analyses are equally effective for diagnostic review. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5666783 Tue, 07 Feb 2012 05:00:00 +0100 5666783 http://www.medworm.com/index.php?rid=5659426&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24043 ConclusionsThe survival rate for children aged 0–14 diagnosed with cancer in Shanghai during 2002–2005 was at the medium level. There was a substantial survival difference from childhood cancers between Shanghai and specific developed countries. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5659426 Sun, 05 Feb 2012 12:57:12 +0100 5659426 http://www.medworm.com/index.php?rid=5647085&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24100 ConclusionTreatment with hydroxyurea for 24 months did not influence GFR in young children with SCA. However, hydroxyurea was associated with better urine concentrating ability and less renal enlargement, suggesting some benefit to renal function. (ClinicalTrials.gov number NCT00006400) Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5647085 Thu, 02 Feb 2012 12:58:40 +0100 5647085 http://www.medworm.com/index.php?rid=5659432&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24104 ConclusionsThe prevalence of MS was 32%, which was significantly higher than in a healthy pediatric population. We recommend prolonged follow‐up for transplant recipients, coupled with enforcement of preventive measures, such as early diagnosis and encouragement of a healthy lifestyle. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5659432 Thu, 02 Feb 2012 05:00:00 +0100 5659432 http://www.medworm.com/index.php?rid=5659431&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24103 We report 11 patients treated with propranolol for KHE and the related variant tufted angioma (TA), six of whom also had KMP. The varied responses to treatment, with only 36% responding in our series, demonstrate the need for further study of this medication before routine use for these indications. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5659431 Thu, 02 Feb 2012 05:00:00 +0100 5659431 http://www.medworm.com/index.php?rid=5659430&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24101 ConclusionsThe dismal outcomes for patients with relapsed and refractory sarcomas and the lack of effective sarcoma salvage regimens highlight the need for new approaches. This report of the therapeutic activity of gemcitabine and docetaxel (GEMDOX) in rhabdomyosarcoma and other pediatric reports describing activity in osteosarcoma and Ewing sarcoma suggest that this combination should be considered for formal evaluation in a pediatric specific clinical trial. At a minimum, it appears to offer a reasonable, tolerable, palliative option. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5659430 Thu, 02 Feb 2012 05:00:00 +0100 5659430 http://www.medworm.com/index.php?rid=5659429&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24102 AbstractSubsequent publication as a complete manuscript is a desirable end‐point for studies presented at scientific meetings. Between 2001 and 2005, 191 studies from India were presented at annual congresses of the International Society of Paediatric Oncology. Of these 24 (12.6%) were published with a median time to publication of 20 months. This subsequent publication rate is lower than previous reports of SPR for either paediatric or oncological meetings. A lower proportion of oral presentations and randomised clinical trials (RCTs) could partly explain our findings. Further research is needed to understand barriers to subsequent publication of presented data from India. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5659429 Thu, 02 Feb 2012 05:00:00 +0100 5659429 http://www.medworm.com/index.php?rid=5659428&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24099 ConclusionsThe PedsQL™ Generic Core Scales, Cancer Module, and Multidimensional Fatigue Scale appear to be feasible for an older population of pediatric cancer survivors; however, some of the Cancer Module Scales (nausea, procedural/treatment anxiety, and communication) were deemed not relevant for long‐term survivors. More information is needed to determine whether the issues addressed by these modules are meaningful to long‐term adult survivors of pediatric cancers. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5659428 Thu, 02 Feb 2012 05:00:00 +0100 5659428 http://www.medworm.com/index.php?rid=5659427&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24097 ConclusionsLumbar CSF was a more informative screen for bHCG than serum but the majority of patients (60%) had normal bHCG values at diagnosis. Until a more sensitive tumor marker for germinoma is devised, histologic confirmation remains the standard of care. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5659427 Thu, 02 Feb 2012 05:00:00 +0100 5659427 http://www.medworm.com/index.php?rid=5647089&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23407 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5647089 Tue, 31 Jan 2012 05:00:00 +0100 5647089 http://www.medworm.com/index.php?rid=5647088&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24094 We report and define a 198 kb deletion removing the entire β‐globin gene cluster, which was found in members of a multigeneration family of Irish/Scottish descent. The proband had life‐threatening fetal and neonatal hemolytic anemia which subsided by 1 year of age. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5647088 Tue, 31 Jan 2012 05:00:00 +0100 5647088 http://www.medworm.com/index.php?rid=5647087&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24095 ConclusionsWe have evaluated in detail children and adults with FA for their growth and endocrine function. Overall, 79% of children and adults with FA had one or more endocrine abnormality. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5647087 Tue, 31 Jan 2012 05:00:00 +0100 5647087 http://www.medworm.com/index.php?rid=5647086&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24096 ConclusionsPatients with ALL experienced important but declining deficits in HRQL during active treatment phases: Equivalent to losing approximately 2 months of life in perfect health. HRQL within the 2‐years post‐treatment phase was similar to controls. The policy challenge is to develop new treatment protocols producing fewer disabilities in mobility/ambulation, emotion, self‐care, and pain without compromising survival. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5647086 Tue, 31 Jan 2012 05:00:00 +0100 5647086 http://www.medworm.com/index.php?rid=5638140&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24087 AbstractAs survival outcomes for bladder/prostate rhabdomyosarcoma have improved over the last 40 years, the emphasis has shifted to minimizing treatment related morbidity. We undertook a critical review of the current literature to examine the role of radical pelvic surgery to achieve local control. We illustrate that there appears to be no difference in overall survival or event free survival when comparing differing modalities utilized in local disease control, microscopic disease clearance does not correlate with improved outcomes, and the morbidity associated with radical surgery for BP RMS is significantly greater than for a conservative method of local control. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5638140 Sun, 29 Jan 2012 12:58:06 +0100 5638140 http://www.medworm.com/index.php?rid=5638142&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24066 ConclusionBevacizumab‐related acute toxicity appears to be low in children, even in combination with irinotecan. Further prospective trials are required to confirm the hypothetical efficacy of bevacizumab and to assess the risk of long‐term toxicity especially in the youngest children. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5638142 Fri, 27 Jan 2012 05:00:00 +0100 5638142 http://www.medworm.com/index.php?rid=5638141&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24079 ConclusionsAssessment of both internalized and externalized problems is required in this population. The impact of pharmacological variables on externalized behavioral problems is likely related to CS use. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5638141 Fri, 27 Jan 2012 05:00:00 +0100 5638141 http://www.medworm.com/index.php?rid=5628127&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24089 ConclusionsPROs do not change the psychosocial content of communication. Paediatric oncologists already address psychosocial issues during the consultation, regardless of the use of a PRO. However, with a PRO available they address these issues more systematically and more often. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5628127 Thu, 26 Jan 2012 13:00:34 +0100 5628127 http://www.medworm.com/index.php?rid=5628130&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24076 ConclusionsIn children with low‐risk FN, the efficacy of first‐day step‐down to oral antimicrobial therapy with amoxicillin and ciprofloxacin in an outpatient setting was non‐inferior to continued hospitalization and intravenous antimicrobial therapy. The safety of this procedure, however, was not assessable with sufficient power. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5628130 Mon, 23 Jan 2012 05:00:00 +0100 5628130 http://www.medworm.com/index.php?rid=5628129&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24081 ConclusionWith this strategy, it was possible to omit or reduce the dose of cranial irradiation while maintaining survival outcomes. The administration of HDMTX therapy was found to be feasible and safe with the precautions described. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5628129 Mon, 23 Jan 2012 05:00:00 +0100 5628129 http://www.medworm.com/index.php?rid=5628128&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24088 ConclusionPreoperative chemotherapy for Wilms tumour causes considerable haematological toxicity and treatment‐related mortality in malnourished Malawian children. A significant number of children have unresectable disease despite preoperative chemotherapy. To reduce treatment related mortality, consideration should be given to starting treatment with reduced doses in acutely malnourished patients. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5628128 Mon, 23 Jan 2012 05:00:00 +0100 5628128 http://www.medworm.com/index.php?rid=5608202&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24092 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5608202 Fri, 20 Jan 2012 12:59:39 +0100 5608202 http://www.medworm.com/index.php?rid=5581032&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24078 ConclusionsDonepezil was well tolerated among childhood BT survivors who had received substantial prior therapy. Based on improved executive function and memory performance in this pilot trial, a randomized placebo controlled trial of this pharmacologic agent is warranted to fully evaluate its efficacy in remediating neurocognitive dysfunction. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581032 Fri, 13 Jan 2012 12:55:45 +0100 5581032 http://www.medworm.com/index.php?rid=5581042&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24077 AbstractBlood component transfusion is an integral part of the care of children with oncologic and hematologic conditions. The complexity of transfusion medicine may however lead to challenges for pediatric hematologists/oncologists. In this review, three commonly encountered areas of transfusion medicine are explored. The approach to the investigation and management of suspected platelet refractoriness is reviewed. The unique transfusion related challenges encountered by children undergoing stem cell transplantation are also discussed. Finally, issues arising out of the care of children with hemoglobinopathies are explored, with an emphasis on the incidence of allo‐ and autoimmunization. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581042 Wed, 11 Jan 2012 05:00:00 +0100 5581042 http://www.medworm.com/index.php?rid=5581041&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24075 Conclusions18F‐FDG PET imaging is a potential imaging biomarker of molecular susceptibility to targeted agents early in treatment for this aggressive form of sarcoma, but may find best use serially for Phase I/II studies where chemotherapy and targeted agents are combined to cytoreduce tumors and abrogate Igf1r inhibitor resistance. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581041 Wed, 11 Jan 2012 05:00:00 +0100 5581041 http://www.medworm.com/index.php?rid=5581040&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24068 ConclusionsA single dose of palonosetron—without concomitant corticosteroid—was effective in preventing both acute and delayed phase CINV in majority of children with ALL treated with HD‐MTX. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581040 Wed, 11 Jan 2012 05:00:00 +0100 5581040 http://www.medworm.com/index.php?rid=5581039&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24067 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581039 Wed, 11 Jan 2012 05:00:00 +0100 5581039 http://www.medworm.com/index.php?rid=5581038&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24064 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581038 Wed, 11 Jan 2012 05:00:00 +0100 5581038 http://www.medworm.com/index.php?rid=5581037&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24059 ConclusionsResults of this study demonstrate a favorable outcome of patients with bilateral WT receiving an individual treatment program. With a tailored approach to treatment according to the tumor response, 77% of our patients were operated before the third month of preoperative chemotherapy. In spite of good survival, 14% of our patients have ESRD. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581037 Wed, 11 Jan 2012 05:00:00 +0100 5581037 http://www.medworm.com/index.php?rid=5581036&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24056 ConclusionA brief neurobehavioral screen in the early period following cancer diagnosis is feasible and provides valuable baseline data for children at risk of neurobehavioral late‐effects of cancer treatments. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581036 Wed, 11 Jan 2012 05:00:00 +0100 5581036 http://www.medworm.com/index.php?rid=5581035&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24055 ConclusionInternational collaboration via FTA cards may be helpful to improve diagnosis and management of patients with hematological malignancies in low‐income and underdeveloped countries. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581035 Wed, 11 Jan 2012 05:00:00 +0100 5581035 http://www.medworm.com/index.php?rid=5581034&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24022 ConclusionsHI‐HSCT is feasible in our setting, offers a rational treatment option, and expands the donor pool significantly for children with high‐risk leukemia in a developing country. This information is especially relevant to other ethnically diverse populations that are poorly represented in international donor registries. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581034 Wed, 11 Jan 2012 05:00:00 +0100 5581034 http://www.medworm.com/index.php?rid=5581033&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23411 ConclusionsThese findings suggest that qualitative assessment of bleeding symptoms alone is not useful in children. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581033 Wed, 11 Jan 2012 05:00:00 +0100 5581033 http://www.medworm.com/index.php?rid=5581049&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24069 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581049 Mon, 09 Jan 2012 05:00:00 +0100 5581049 http://www.medworm.com/index.php?rid=5581048&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24070 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581048 Mon, 09 Jan 2012 05:00:00 +0100 5581048 http://www.medworm.com/index.php?rid=5581047&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24072 ConclusionsCirculating VEGF is significantly increased in pediatric patients with newly diagnosed RMS. Further studies in larger series of RMS patients are needed to understand whether measurements of circulating VEGF might have a role in assessing prognosis and modulating treatment. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581047 Mon, 09 Jan 2012 05:00:00 +0100 5581047 http://www.medworm.com/index.php?rid=5581046&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24062 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581046 Mon, 09 Jan 2012 05:00:00 +0100 5581046 http://www.medworm.com/index.php?rid=5581045&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24074 AbstractPediatric renal cell carcinoma (RCC) is rare and different from adult RCC. Although target agents have recently been introduced, allogeneic hematopoietic stem cell transplantation exploiting graft‐versus‐tumor effect still remains an important treatment option for metastatic RCC. A 2‐year‐old male with RCC developed hepatic metastases 6 months following radical nephrectomy and subsequent cytokine therapy. Allogeneic reduced‐intensity stem cell transplantation (RIST) with early withdrawal of immunosuppression and delayed donor lymphocyte infusions was performed. A second transplantation was undertaken following marrow aplasia. Now he remains progression‐free with regression of hepatic metastases 5.7 years after RIST, along with complete donor chimerism. Pediatr Blood Can... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581045 Mon, 09 Jan 2012 05:00:00 +0100 5581045 http://www.medworm.com/index.php?rid=5581044&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23413 ConclusionsA new clinically based ICT‐Sat tool was developed and revealed good psychometric characteristics. Adherence to ICT was better correlated with “perceived effectiveness” and SF level. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581044 Mon, 09 Jan 2012 05:00:00 +0100 5581044 http://www.medworm.com/index.php?rid=5581043&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24023 AbstractThis systematic review provides information on malignant melanoma as second malignant neoplasm (SMN) after childhood cancer and evaluates its risk factors. Study reports describing incidences of SMN and malignant melanoma as SMN in a population of childhood cancer survivors (CCS) were included. Of 151,575 CCS, 4,010 (2.6%) children developed an SMN, 212 of which were melanoma (5.3% or 0.14% of all CCS). The following risk factors for malignant melanoma as SMN were identified: radiotherapy, or the combination alkylating agents and anti‐mitotic drugs. Melanomas are most frequently observed after Hodgkin disease, hereditary retinoblastoma, soft tissue sarcoma, and gonadal tumors. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5581043 Mon, 09 Jan 2012 05:00:00 +0100 5581043 http://www.medworm.com/index.php?rid=5571985&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23355 AbstractWe evaluated the effects of body mass index (BMI) on the risk of thromboembolism (TE) in children (<18 years) with hematological malignancies during the period 1990–2009 (n = 359). Obesity was prevalent in 12% of patients: 6% versus 17% prior to and after the year 2000 (P = 0.02). Sixty‐one (17%) patients developed TE; increasing BMI was associated with increased, but statistically insignificant risk of TE [adjusted odds ratios (OR): 0.75 (95%CI 0.32–1.77), 0.93 (95%CI 0.38–2.30), and 1.01(95%CI 0.42–2.41) for underweight, overweight, and obese group]. A large prospective study is needed to define the impact of BMI on the risk of TE in children. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5571985 Sun, 08 Jan 2012 12:57:07 +0100 5571985 http://www.medworm.com/index.php?rid=5571986&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23335 We present here a novel case of morphological infantile lipoblastoma showing a rearrangement of HMGA2 instead of the classical PLAG1 alteration. HMGA2 is the main target of clonal aberrations encountered in lipomas. This result supports the hypothesis that benign lipomatous tumors harboring PLAG1 or HMGA2 rearrangement could constitute a unique pathogenetic entity. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5571986 Fri, 06 Jan 2012 05:00:00 +0100 5571986 http://www.medworm.com/index.php?rid=5559484&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23327 We describe a pediatric case of T‐cell ALL with amplification of the ABL1 gene in which remission was achieved only after the addition of dasatinib to conventional chemotherapy. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5559484 Wed, 04 Jan 2012 17:25:21 +0100 5559484 http://www.medworm.com/index.php?rid=5571989&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24057 ConclusionsBoth TS and PS result in favorable hematologic outcomes and low risk of adverse events for children with SCD. A REDCap‐based registry may facilitate data entry and analysis of clinical outcomes to allow for comparison between different types of splenectomy. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5571989 Wed, 04 Jan 2012 05:00:00 +0100 5571989 http://www.medworm.com/index.php?rid=5571988&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24061 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5571988 Wed, 04 Jan 2012 05:00:00 +0100 5571988 http://www.medworm.com/index.php?rid=5571987&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24065 ConclusionsNationally representative hospital data indicate modest but meaningful reductions in LOS for children with VOC over a 12‐year period. Adolescents who typically have the greatest disease severity showed the largest reduction in LOS. However, adolescents continue to account for a large proportion of inpatient stays for VOC. These findings illustrate that the adolescent period is a critical time in the lifespan for targeted intervention. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5571987 Wed, 04 Jan 2012 05:00:00 +0100 5571987 http://www.medworm.com/index.php?rid=5559485&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24003 We report a 5‐month‐old who presented with an MYCN‐amplified INSS stage 3, pelvic neuroblastoma. The tumor had favorable histology, hyperdiploidy, and lacked 1p36 and 11q23 aberrations. Although the patient met the criteria for high‐risk neuroblastoma, because of the discordant prognostic markers we elected to treat her according to an intermediate‐risk protocol. She remains event‐free more than 18 months. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5559485 Sun, 01 Jan 2012 05:00:00 +0100 5559485 http://www.medworm.com/index.php?rid=5544199&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24058 We describe a novel presentation of hypothalamic obesity syndrome in CNS B‐cell lymphoblastic lymphoma, responsive to chemotherapy. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5544199 Wed, 28 Dec 2011 04:38:32 +0100 5544199 http://www.medworm.com/index.php?rid=5544201&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24063 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5544201 Tue, 27 Dec 2011 05:00:00 +0100 5544201 http://www.medworm.com/index.php?rid=5544200&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24052 We report a novel case of a solid tumor in a patient with SDS and biallelic mutations in the Shwachman Bodian Diamond Syndrome gene (SBDS). Whether the development of breast cancer in this patient is due to SDS or an isolated case due to unknown factors requires further study. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5544200 Tue, 27 Dec 2011 05:00:00 +0100 5544200 http://www.medworm.com/index.php?rid=5524150&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24047 ConclusionsAt early response assessment by FDG‐PET, patient‐specific correction of ΔSUVmax by BSA improves PPV without impairment of excellent NPV in pHL. However, it is not statistically superior to simple ΔSUVmax‐analyses. Larger cohorts are needed to investigate this observation. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524150 Thu, 22 Dec 2011 01:30:23 +0100 5524150 http://www.medworm.com/index.php?rid=5524161&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24054 AbstractMyxopapillary ependymoma (MPE) is a rare subtype of ependymoma in children. Though classified as a Grade I tumor, their unpredictable behavior and propensity for local and disseminated recurrence poses a therapeutic challenge. Till date no predictive molecular markers exist for such recurrence, especially with dissemination. We demonstrated that Epidermal Growth Factor Receptor (EGFR) expression was seen in relapsed MPE both at diagnosis and at recurrence and none in the nonrecurring tumors. This finding suggests EGFR could be a predictive biomarker for recurrence in MPE. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524161 Tue, 20 Dec 2011 05:00:00 +0100 5524161 http://www.medworm.com/index.php?rid=5524160&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24060 AbstractDiffuse intrinsic pontine gliomas (DIPG) can not be cured with current treatment modalities. Targeted therapy in this disease would benefit from advanced technologies detecting relevant drugable mutations. Twenty patients with classic newly diagnosed DIPG underwent stereotactic biopsies and were analyzed for the presence of 983 different mutations in 115 oncogenes and tumor‐suppressor genes using OncoMap, a mass spectrometric method of allele detection. Our results identified oncogenic mutations in TP53 (40%), PI3KCA (15%), and ATM/MPL (5%) while none were identified in a large number of other genes commonly mutated in malignant gliomas. The identification of oncogenic mutations in the PI3K pathway offers the potential of a therapeutic target at initial diagnosis in this devastat... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524160 Tue, 20 Dec 2011 05:00:00 +0100 5524160 http://www.medworm.com/index.php?rid=5524159&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24016 AbstractPazopanib is an oral angiogenesis inhibitor targeting vascular growth factor receptor‐1, ‐2, and ‐3, platelet derived growth factor receptor‐α, platelet derived growth factor receptor‐β, and KIT that has demonstrated activity against a variety of adult cancer xenografts. Pazopanib was tested against a panel of pediatric rhabdomyosarcoma and Ewing sarcoma xenografts at a dose of 108 mg/kg/day or 100 mg/kg twice daily, administered orally for 28 days. While no objective responses were observed, pazopanib induced statistically significant differences in event‐free survival compared to controls in approximately one‐half of the sarcoma xenograft models tested. Though well tolerated, pazopanib showed limited activity against the sarcoma models evaluated, with the best... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524159 Tue, 20 Dec 2011 05:00:00 +0100 5524159 http://www.medworm.com/index.php?rid=5524158&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24027 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524158 Tue, 20 Dec 2011 05:00:00 +0100 5524158 http://www.medworm.com/index.php?rid=5524157&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24029 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524157 Tue, 20 Dec 2011 05:00:00 +0100 5524157 http://www.medworm.com/index.php?rid=5524156&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24037 ConclusionInfants with more severe anemia are at risk for increased clinical events that may be prevented by early initiation of hydroxyurea. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524156 Tue, 20 Dec 2011 05:00:00 +0100 5524156 http://www.medworm.com/index.php?rid=5524155&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24038 ConclusionsExtent of tumor necrosis following neo‐adjuvant chemotherapy is an independent prognostic factor in patients with newly diagnosed HB. Histological response may potentially be used in strategies to modify post‐surgical therapy to improve survival in HB. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524155 Tue, 20 Dec 2011 05:00:00 +0100 5524155 http://www.medworm.com/index.php?rid=5524154&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24041 AbstractGlanzmann thrombasthenia (GT) is an autosomal recessive bleeding disorder caused by defective glycoprotein, αIIb and β3, encoded by ITGA2B and ITGB3 genes, respectively. We herein describe four unrelated Korean patients with genetically confirmed GT. Two patients were homozygous for c.1913+5G>T (IVS11+5G>T) mutation of ITGB3 with a signature of founder effect. The other two patients were compound heterozygous for two mutations of ITGA2B: c.[2333A>C];[2975delA] (p.[Q778P];[E992Gfs*30]) and c.[1750C>T];[2333A>C] (p.[R584X];[Q778P]). The c.2975delA mutation was a novel frameshift mutation of ITGA2B. Although from a limited number of patients, these results suggests c.1913+5G>T of ITGB3 is a recurrent mutation in Korean patients with GT. Pediatr Blood Cancer © 2011... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524154 Tue, 20 Dec 2011 05:00:00 +0100 5524154 http://www.medworm.com/index.php?rid=5524153&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24044 ConclusionsIt is suggested that the exposure to a life‐threatening experience in childhood/adolescence increases the endocrine response to stress, and that the presence of depressive symptoms is associated with an elevation of plasma cortisol levels. A better knowledge of these mechanisms is important given that the dysregulations of the stress responses may cause psychological vulnerability. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524153 Tue, 20 Dec 2011 05:00:00 +0100 5524153 http://www.medworm.com/index.php?rid=5524152&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24046 ConclusionGreater treatment intensity is associated with need for more PRBC transfusions, and thus increased risk of iron overload among childhood cancer survivors. Iron overload may represent another clinically significant late effect following childhood cancer treatment. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524152 Tue, 20 Dec 2011 05:00:00 +0100 5524152 http://www.medworm.com/index.php?rid=5524151&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24040 ConclusionsOlder age and lower LS‐BMD at diagnosis are predictors of lower LS‐BMD during continuation therapy. Dexamethasone and lower LS‐BMD during continuation therapy are associated with fractures. Using these variables it is feasible to develop a predictor model to define the risk of bony morbidity in children receiving ALL therapy. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524151 Tue, 20 Dec 2011 05:00:00 +0100 5524151 http://www.medworm.com/index.php?rid=5524173&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23401 We report the case of a child with a diagnosis of JMML carrying two mutations of NRAS gene (c.37G>C and c.38G>A) independently occurring in long‐term culture initiating cells. However, only the former was consistently found in more mature hematopoietic cells, suggesting that cancer transformation may lead to the loss of a mutation. This case also indicates that molecular analysis on cell types other than peripheral blood leukocytes may be useful to obtain relevant biological information on JMML pathogenesis. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524173 Mon, 19 Dec 2011 05:00:00 +0100 5524173 http://www.medworm.com/index.php?rid=5524172&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24034 ConclusionThese results support the contention that Akt activation is a mechanism of chemotherapeutic resistance in B‐pre ALL and suggest that Akt can be a therapeutic target for the treatment of relapsed or refractory pediatric B‐pre ALL. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524172 Mon, 19 Dec 2011 05:00:00 +0100 5524172 http://www.medworm.com/index.php?rid=5524171&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24035 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524171 Mon, 19 Dec 2011 05:00:00 +0100 5524171 http://www.medworm.com/index.php?rid=5524170&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24036 ConclusionsChildren with hemoglobinopathies had higher physical and emotional functioning scores prior to HSCT and experienced a similar pattern of recovery to their baseline functioning by 3 months post‐HSCT when compared to children receiving HSCT for acquired conditions. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524170 Mon, 19 Dec 2011 05:00:00 +0100 5524170 http://www.medworm.com/index.php?rid=5524169&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24039 ConclusionsNo cytotoxic agents were needed for >60% of EBV‐HLH patients. Early immunotherapy may modulate T‐cell activation and reduce the chance of unnecessary chemotherapy. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524169 Mon, 19 Dec 2011 05:00:00 +0100 5524169 http://www.medworm.com/index.php?rid=5524168&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24042 ConclusionsPatients with HPT appear to be at high risk to develop permanent neuroendocrine consequences. Coordinated studies for patients with LCH and HP disease including thorough MRI monitoring and neuropsychological tests are needed. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524168 Mon, 19 Dec 2011 05:00:00 +0100 5524168 http://www.medworm.com/index.php?rid=5524167&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24045 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524167 Mon, 19 Dec 2011 05:00:00 +0100 5524167 http://www.medworm.com/index.php?rid=5524166&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24048 We report our experience with nine pediatric patients weighing between 4.33 and 19.9 kg and a total of 23 PBSC collection aphereses. None of our patients experienced any major complications. We conclude that PBSC apheresis in children is a safe method. It should be based on a standardized procedure that includes the determination of clinical and laboratory parameters and appropriate monitoring. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524166 Mon, 19 Dec 2011 05:00:00 +0100 5524166 http://www.medworm.com/index.php?rid=5524165&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24049 ConclusionsA simple home‐based exercise program was effective in improving cardiometabolic risk factor status and fitness in young adult survivors of childhood ALL. Simple exercise programs should be recommended to this population with increased risk of CVD to improve metabolic risk factor status and fitness. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524165 Mon, 19 Dec 2011 05:00:00 +0100 5524165 http://www.medworm.com/index.php?rid=5524164&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24050 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524164 Mon, 19 Dec 2011 05:00:00 +0100 5524164 http://www.medworm.com/index.php?rid=5524163&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24051 ConclusionsOur results reflect the current practice of pediatric thyroid FNB in Germany. In order to improve its usefulness, FNB should always be performed by experienced physicians. Furthermore, a central review of all specimens is necessary to ascertain the validity of the cytological diagnosis and to introduce immunocytological and molecular methods. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524163 Mon, 19 Dec 2011 05:00:00 +0100 5524163 http://www.medworm.com/index.php?rid=5524162&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24053 ConclusionsPatients with extraskeletal Ewing sarcoma should undergo evaluation for regional node involvement. If validated, our findings indicate that regional node involvement may be an independent adverse prognostic factor in Ewing sarcoma, and potentially useful in risk‐stratifying patients with otherwise localized disease. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5524162 Mon, 19 Dec 2011 05:00:00 +0100 5524162 http://www.medworm.com/index.php?rid=5515100&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24032 ConclusionsThe pathways of care for French adolescent patients with cancer are heterogeneous. Our results reveal differences in MDT meetings according to tumor types and a lack of effective collaboration between pediatric and adult wards. Efforts must be made to develop cancer networks to ensure that adolescents receive the optimal care in a suitable environment. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515100 Mon, 19 Dec 2011 01:27:25 +0100 5515100 http://www.medworm.com/index.php?rid=5515113&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23223 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515113 Fri, 16 Dec 2011 05:00:00 +0100 5515113 http://www.medworm.com/index.php?rid=5515112&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23399 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515112 Fri, 16 Dec 2011 05:00:00 +0100 5515112 http://www.medworm.com/index.php?rid=5515111&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24014 ConclusionOur results indicate that MDM2 and MDM4 polymorphisms may influence development and/or survival in RB. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515111 Fri, 16 Dec 2011 05:00:00 +0100 5515111 http://www.medworm.com/index.php?rid=5515110&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24017 ConclusionsSurvivors of childhood cancer demonstrate substantially higher hospitalization rates. Additional research is needed to further quantify the healthcare utilization and economic impact of treatment‐related complications as this population ages. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515110 Fri, 16 Dec 2011 05:00:00 +0100 5515110 http://www.medworm.com/index.php?rid=5515109&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24019 ConclusionsWe report on the long‐term outcome in patients with biallelic MMR mutations who benefited from prophylactic cancer surveillance. Genetic screening and subsequent surveillance led to earlier recognition of asymptomatic tumors at stages more amenable to resection and probable cure. Multicenter collaboration and implementation of surveillance guidelines is necessary to further determine genotype–phenotype correlations. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515109 Fri, 16 Dec 2011 05:00:00 +0100 5515109 http://www.medworm.com/index.php?rid=5515108&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24020 AbstractEmbryonal rhabdomyosarcoma (ERMS) is the most common childhood sarcoma and is a component of the familial pleuropulmonary blastoma (PPB)‐predisposition syndrome. Using the PPB model, we hypothesized that DICER1 mutations would be found in familial and sporadic forms of ERMS. Blood samples from four children with familial PPB and ERMS, and 52 sporadic ERMS tumors were tested for DICER1 mutations. Germline DICER1 mutations were found in all four patients with familial PPB and 2 of 52 (3.8%) sporadic ERMS had somatic mutations. Our findings confirm the pathogenetic relationship between ERMS and PPB suggesting that ERMS may result from abnormal miRNA regulation. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515108 Fri, 16 Dec 2011 05:00:00 +0100 5515108 http://www.medworm.com/index.php?rid=5515107&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24021 ConclusionsThe absence of TCRγ deletion is a predictor of a poor response to induction chemotherapy for pediatric patients with T‐cell ALL in Taiwan. Providing patients with T‐cell ALL and ABD with alternative regimens may be worthwhile to test in future clinical trials. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515107 Fri, 16 Dec 2011 05:00:00 +0100 5515107 http://www.medworm.com/index.php?rid=5515106&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24024 In this report, we show that Delta‐like 1 homolog (DLK1), a protein highly expressed during fetal development, but almost completely absent after birth, and an established liver‐stem cell marker, is a new candidate serum marker of hepatoblastoma, especially in young infants. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515106 Fri, 16 Dec 2011 05:00:00 +0100 5515106 http://www.medworm.com/index.php?rid=5515105&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24025 ConclusionsGenes highly expressed in WT compared to fetal kidney are generally overexpressed in all of the three common WT tissue elements. An exception is the predominant expression of SIX1 in blastemal cells, hereby identifying this protein as a candidate marker for blastema. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515105 Fri, 16 Dec 2011 05:00:00 +0100 5515105 http://www.medworm.com/index.php?rid=5515104&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24026 ConclusionsYounger patients had increased transplant toxicity, with infants <1 year of age at highest risk for fever, bacteremia, admission to intensive care, and death. Infants would likely benefit from hospitalization after autologous HCT until neutrophil recovery. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515104 Fri, 16 Dec 2011 05:00:00 +0100 5515104 http://www.medworm.com/index.php?rid=5515103&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24028 ConclusionsAdults and patients with public insurance or no insurance are more likely to use multiple hospitals for acute care. By receiving acute care at multiple hospitals, patients with SCD experience dispersed and fragmented care potentially leading to decreased care quality. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515103 Fri, 16 Dec 2011 05:00:00 +0100 5515103 http://www.medworm.com/index.php?rid=5515102&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24030 We describe a 6‐year‐old male with refractory NB who relapsed 22 months after haplo‐HSCT. A complete remission was obtained with a combination of immuno‐chemotherapy based on donor NK cells transplants, IL2 infusions and temozolomide/topotecan. This case is an incentive to explore both the immediate therapeutic effect of haplo‐graft provided via haplo‐NK cells and the immunogenic platform that haplo‐HSCT offers for future treatment. Our post‐relapse strategy shows that chemo‐ and bio‐treatment should be viewed as complementary therapeutic options. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515102 Fri, 16 Dec 2011 05:00:00 +0100 5515102 http://www.medworm.com/index.php?rid=5515101&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24031 ConclusionES patients who are younger, of Latino ethnicity, have pelvic tumors or low income have higher rates of toxicity that may require increased supportive care. Treatment on a clinical trial was also associated with higher rates of toxicity, though this finding may reflect better reporting in these patients. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5515101 Fri, 16 Dec 2011 05:00:00 +0100 5515101 http://www.medworm.com/index.php?rid=5504374&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23400 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5504374 Fri, 16 Dec 2011 01:29:52 +0100 5504374 http://www.medworm.com/index.php?rid=5494651&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24033 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494651 Tue, 13 Dec 2011 01:39:17 +0100 5494651 http://www.medworm.com/index.php?rid=5494650&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23288 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494650 Tue, 13 Dec 2011 01:39:08 +0100 5494650 http://www.medworm.com/index.php?rid=5494649&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23260 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494649 Tue, 13 Dec 2011 01:39:06 +0100 5494649 http://www.medworm.com/index.php?rid=5494648&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23326 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494648 Tue, 13 Dec 2011 01:38:36 +0100 5494648 http://www.medworm.com/index.php?rid=5494638&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23398 In this report we describe two patients with an isolated and apparently sporadic adrenocortical tumor; one girl with a carcinoma, the other girl with an adenoma. In both patients genetic screening revealed hypomethylation of the KCNQ1OT1 gene, well‐known for its association with the Beckwith–Wiedemann syndrome. This represents a likely novel genetic predisposition in patients with adrenocortical tumors without clear phenotypic features of the Beckwith–Wiedemann syndrome. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494638 Tue, 13 Dec 2011 01:34:48 +0100 5494638 http://www.medworm.com/index.php?rid=5494647&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23402 ConclusionThis approach warrants further, systematic evaluation as proof of concept and then expansion to drug‐specific hypotheses. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494647 Sun, 11 Dec 2011 05:00:00 +0100 5494647 http://www.medworm.com/index.php?rid=5494646&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23403 ConclusionsDetection of the EWS‐WT1‐GFT plays a major role in the diagnosis of DSRCT. No survival difference was observed according to extent of surgery, but complete surgery seemed to offer the best chance of long‐term survival. High‐dose chemotherapy or local radiotherapy did not appear to improve survival in this retrospective analysis, but larger prospective studies are needed to provide definitive conclusions on the role of these treatments. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494646 Sun, 11 Dec 2011 05:00:00 +0100 5494646 http://www.medworm.com/index.php?rid=5494645&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24000 ConclusionThe decreased systolic reserve induced by a low dose of anthracycline in asymptomatic children and adolescents remains unaffected over a 5‐year period, suggesting that positive outcomes in chronic cardiotoxicity would be expected in patients with mild impairment after anthracycline treatment. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494645 Sun, 11 Dec 2011 05:00:00 +0100 5494645 http://www.medworm.com/index.php?rid=5494644&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24008 AbstractThere is growing evidence for the importance of chronic inflammation in the pathogenesis of adult cancers and for an ongoing role of the inflammatory response in tumor growth and metastasis. Here, we examine how these processes relate to pediatric malignancies. While it is unlikely that chronic inflammation plays a significant role in driving malignant progression in childhood tumors that typically have developmental origins, the inflammatory response does appear to play an important role in the development and progression of many types of childhood cancer. An enhanced understanding of these processes will be of critical importance in developing novel therapeutic strategies. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494644 Sun, 11 Dec 2011 05:00:00 +0100 5494644 http://www.medworm.com/index.php?rid=5494643&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24010 ConclusionEarly CVC placement at the time of diagnosis of ALL was associated with a low surgical complication rate with no catheters requiring removal due to infection. Utilizing our current methods of preoperative preparation, surgical management and postoperative CVC care, early placement of a CVC is safe in children with ALL even when their ANC is <500/mm3, but larger cohort studies would be helpful to further clarify this issue. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494643 Sun, 11 Dec 2011 05:00:00 +0100 5494643 http://www.medworm.com/index.php?rid=5494642&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24011 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494642 Sun, 11 Dec 2011 05:00:00 +0100 5494642 http://www.medworm.com/index.php?rid=5494641&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24012 ConclusionUnhealthy body weight and overfatness may be common amongst adolescent Saudi survivors of standard risk ALL, though overweight and obesity may be no more common than in the general Saudi adolescent population. Defining weight status using BMI underestimates overfatness. Ideally, body composition and cardiometabolic risk factors should be monitored at late effects clinics. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494641 Sun, 11 Dec 2011 05:00:00 +0100 5494641 http://www.medworm.com/index.php?rid=5494640&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24013 ConclusionsHigh proliferative activity in the primary tumor following induction therapy portends a poor outcome in patients with high‐risk neuroblastoma. If confirmed in a larger cohort, tumor histology at second‐look surgery could be used to define a subset of very high risk patients who would benefit from alternative therapies prior to myeloablative dose‐intensive transplant. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494640 Sun, 11 Dec 2011 05:00:00 +0100 5494640 http://www.medworm.com/index.php?rid=5494639&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24015 ConclusionThis study shows that IGF‐I has limited value as a marker for alterations in body composition in adult childhood cancer survivors. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5494639 Sun, 11 Dec 2011 05:00:00 +0100 5494639 http://www.medworm.com/index.php?rid=5486468&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24018 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5486468 Sat, 10 Dec 2011 01:37:27 +0100 5486468 http://www.medworm.com/index.php?rid=5476195&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24002 AbstractMedullomyoblastoma (MMB) is a rare variant of medulloblastoma, a member of the family of central nervous system (CNS) embryonal tumors. The outcome of standard therapy for CNS embryonal tumors is often unpredictable in the setting of MMB. Here, we present the clinical course and treatment of an almost 4‐year‐old girl with MMB that was characterized by MYC amplification, isochromosome 17q and large cell/anaplastic histopathology. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5476195 Wed, 07 Dec 2011 01:36:29 +0100 5476195 http://www.medworm.com/index.php?rid=5476203&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24001 ConclusionsPediatric patients with Ewing sarcoma or osteosarcoma are at an increased risk for developing malnutrition, in the form of either over‐ or underweight during multimodality therapy. Early recognition of abnormal body mass is required to prevent and to treat long‐term comorbidities caused by malnutrition. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5476203 Tue, 06 Dec 2011 05:00:00 +0100 5476203 http://www.medworm.com/index.php?rid=5476202&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23419 AbstractUneven strides in research and care have led to discrepancies in childhood cancer outcomes between high and low income countries (LICs). Collaborative research may help improve outcomes in LICs by generating knowledge for local scientific communities, augmenting knowledge translation, and fostering context‐specific evaluation of treatment protocols. However, the risks of such research have received little attention. This paper investigates the relationship between pediatric oncology research in LICs and four core issues in the ethics literature: standard of care, trial benefits, ethics review, and informed consent. Our aims are to highlight the importance of this field and the need for further inquiry. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood ... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5476202 Tue, 06 Dec 2011 05:00:00 +0100 5476202 http://www.medworm.com/index.php?rid=5476201&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23418 ConclusionsTime to antibiotic administration exceeded 1 hour. The chart review and lean process suggested targets for educational and infrastructural interventions, including an ED pre‐printed order sheet, targeted combined subspecialty education between emergency and hematology/oncology staff, and family education. A mixed methodology approach represents a model for improving process efficiency and meeting “best‐practice” targets in medicine. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5476201 Tue, 06 Dec 2011 05:00:00 +0100 5476201 http://www.medworm.com/index.php?rid=5476200&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23410 ConclusionThis report highlights a high rate of bone marrow failure along with a low rate of hemoglobinuria at presentation, a high rate of thrombosis, and for some patients the spontaneous resolution of myelodysplastic features. Delay in diagnosis is common and we recommend appropriate PNH testing in all patients with AA, MDS, unexplained Coombs‐negative hemolysis, or thrombosis. While HSCT remains the only curative option the high prevalence of hemolysis and thrombosis should warrant the consideration of early treatment with anti‐complement therapy. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5476200 Tue, 06 Dec 2011 05:00:00 +0100 5476200 http://www.medworm.com/index.php?rid=5476199&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23324 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5476199 Tue, 06 Dec 2011 05:00:00 +0100 5476199 http://www.medworm.com/index.php?rid=5476198&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24006 ConclusionOur results suggest that the chosen antiangiogenic drug combination is particularly beneficial for patients with MB and warrants further investigation. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5476198 Tue, 06 Dec 2011 05:00:00 +0100 5476198 http://www.medworm.com/index.php?rid=5476197&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24005 AbstractThe V600E mutation of the BRAF gene has been reported to be associated with poor prognosis of germ cell tumors in adult patients. We analyzed the mutational status of the BRAF and KRAS gene as well as MLH1 and MSH6 expression as surrogate markers for microsatellite instability in 70 pediatric germ cell tumors. Neither BRAF and KRAS mutations nor loss of MLH1 and MSH6 expression were found. Our data provide further evidence for patient age related biological differences in germ cell tumors and demonstrate that prognostic biomarkers cannot necessarily be transferred from one age group to the other. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5476197 Tue, 06 Dec 2011 05:00:00 +0100 5476197 http://www.medworm.com/index.php?rid=5476196&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24004 ConclusionsOur results demonstrate that sorafenib inhibits the growth of neuroblastoma tumors by targeting both neuroblastoma cells and tumor blood vessels. Single agent sorafenib should be evaluated in future phase II neuroblastoma studies. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5476196 Tue, 06 Dec 2011 05:00:00 +0100 5476196 http://www.medworm.com/index.php?rid=5431382&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23404 We report the case of a child who presented with nonspecific symptoms suggestive of a rheumatologic disorder, whose bone marrow had a complex translocation involving the FGFR1 locus. Hematopathologic findings were subtle and did not definitively indicate malignancy. Because he responded poorly to initial treatment with hydroxyurea, and in light of the progressive clinical course associated with the 8p11 myeloproliferative syndrome, he underwent an unrelated‐donor hematopoietic stem cell transplant. This patient's atypical presentation highlights the importance of obtaining cytogenetic analysis at the time of bone marrow sampling and considering this uncommon entity in the differential diagnosis of hematologic disorders. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediat... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5431382 Tue, 22 Nov 2011 01:32:53 +0100 5431382 http://www.medworm.com/index.php?rid=5431389&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23406 ConclusionsOur results demonstrate that the function of Ikaros is cell cycle‐specific and controlled by CK2‐mediated phosphorylation during S phase of the cell cycle in human T‐cell and B‐cell ALL. The differences we observe in murine and human Ikaros function highlight the importance of using human cells in studies of ALL. These data identify the CK2 pathway as a target for therapies in ALL. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5431389 Mon, 21 Nov 2011 05:00:00 +0100 5431389 http://www.medworm.com/index.php?rid=5431388&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23409 ConclusionAlthough JAK2 mutations in childhood ET and PV are not as frequent as reported in adult patients, JAK2 is the most frequently mutated gene in childhood MPN known so far. Owing to the presence of childhood MPN without any genetic alterations in JAK2, MPL, TET2, ASXL1, CBL, IDH1, and IDH2, new biological markers have to be found. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5431388 Mon, 21 Nov 2011 05:00:00 +0100 5431388 http://www.medworm.com/index.php?rid=5431387&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23405 AbstractHaemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome caused by deficient down‐regulation of the immune response. Presence of central nervous system (CNS) involvement at diagnosis is a poor prognostic sign, and should be carefully investigated. Herein, we describe the neuroradiological findings, clinical data, and treatment outcome in 12 patients with genetic HLH and CNS complications. Neuroimaging was important in identifying CNS involvement, monitoring treatment responses, and detecting treatment complications. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5431387 Mon, 21 Nov 2011 05:00:00 +0100 5431387 http://www.medworm.com/index.php?rid=5431386&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23408 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5431386 Mon, 21 Nov 2011 05:00:00 +0100 5431386 http://www.medworm.com/index.php?rid=5431385&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23371 AbstractChildren with Down syndrome (DS) bear an increased risk of acute lymphoblastic leukemia (ALL) and treatment complications. We compared blood counts and toxicities in 22 DS and 44 non‐DS ALL patients. Patients with DS had deeper, longer neutrophil and monocyte count nadirs; more toxicities (HR 2.0, P = 0.0005); longer hospitalizations (HR 1.4, P < 0.0001); and more frequent microbiologically documented infections (HR 5.7, P = 0.0019), mucositis (HR 29.0, P = 0.0006), and cellulitis (HR 3.0, P = 0.033). Severe neutropenia, monocytopenia, and increased cellulitis in DS‐ALL suggest the importance of skin hygiene, vigilance and aggressive treatment of cutaneous infections. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5431385 Mon, 21 Nov 2011 05:00:00 +0100 5431385 http://www.medworm.com/index.php?rid=5431384&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23396 ConclusionAnticoagulation with enoxaparin based on adult literature may be suboptimal in preventing rVTE in pediatric populations. Future prospective randomized controlled trials in pediatrics using clinical outcomes with anticoagulant therapy are urgently needed. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5431384 Mon, 21 Nov 2011 05:00:00 +0100 5431384 http://www.medworm.com/index.php?rid=5431383&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23397 ConclusionAge‐related differences exist in the frequency of mutations and it appears that promoter hypermethylation occurs in a non‐random pattern in childhood AML accompanying specific genetic aberrations, and might represent an important step in the leukemogenic transformation. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5431383 Mon, 21 Nov 2011 05:00:00 +0100 5431383 http://www.medworm.com/index.php?rid=5421647&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24007 AbstractEffectiveness of a nurse educator in the pediatric oncology unit in Guatemala was assessed by measuring completion of an education course, chemotherapy and central line competency, continuing education, and cost. All newly hired nurses completed the education course. Of the nurses employed, 86% participated in the chemotherapy course, and 93% achieved competency; 57% participated in the central line course, and 79% achieved competency. The nurses completed a mean of 26 hours continuing education yearly. The annual direct cost of the educator ($244/nurse) was markedly less than other models. This is an effective and sustainable means to educate nurses in low‐income countries. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5421647 Sat, 19 Nov 2011 01:31:14 +0100 5421647 http://www.medworm.com/index.php?rid=5421653&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23395 ConclusionsALC, a readily obtainable test, constitutes a significant and independent prognostic factor in childhood ALL that may refine current MRD‐based risk stratification algorithms and provide key prognostic information in settings where MRD determination is not feasible. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5421653 Fri, 18 Nov 2011 05:00:00 +0100 5421653 http://www.medworm.com/index.php?rid=5421652&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23412 ConclusionsMK‐2206 showed its most consistent activity in vitro against ALL cell lines and in vivo against osteosarcoma xenografts. However, no objective responses were observed in solid tumor or ALL xenografts. Further preclinical work evaluating MK‐2206 in pediatric models in the combination therapy setting may contribute to its pediatric development. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5421652 Fri, 18 Nov 2011 05:00:00 +0100 5421652 http://www.medworm.com/index.php?rid=5421651&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23414 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5421651 Fri, 18 Nov 2011 05:00:00 +0100 5421651 http://www.medworm.com/index.php?rid=5421650&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23415 AbstractA severe complication of the treatment of pediatric cancers is the development of an invasive fungal infection (IFI). The data to support antifungal prophylaxis in pediatric oncology patients derive primarily from adult patients, and thus the optimal agent to utilize is not clear. Fluconazole has been a standard option, but agents with antimold activity are now available, each with limitations. Pediatric dosing for voriconazole and posaconazole is uncertain and multiple drug interactions exist. The echinocandins are well‐tolerated, but only available in intravenous form. Ultimately, studies demonstrating biologic risk factors for the development of IFI may lead to personalized prophylactic strategies. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood a... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5421650 Fri, 18 Nov 2011 05:00:00 +0100 5421650 http://www.medworm.com/index.php?rid=5421649&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23416 AbstractBacterial sepsis continues to be a leading cause of morbidity and toxic death in children receiving intensive therapy for cancer. Empiric therapy for suspected infections and treatment of documented infections are well‐established standards of care. The routine use of prophylactic strategies is much less common in pediatric oncology. This paper will review the current literature on the use and risks of antimicrobial prophylaxis as well as non‐pharmacological methods for infection prevention and will address areas in need of further research. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5421649 Fri, 18 Nov 2011 05:00:00 +0100 5421649 http://www.medworm.com/index.php?rid=5421648&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23417 AbstractIn pediatric patients with malignancy and those receiving hematopoietic stem cell transplants, bacterial and fungal infections have been the focus of fever and neutropenia episodes for decades. However, improved diagnostic capabilities have revealed viral pathogens as a significant cause of morbidity and mortality. Because of limited effective antiviral therapies, prevention of viral infections is paramount. Pre‐exposure and post‐exposure prophylaxis and antiviral suppressive therapeutic approaches are reviewed. Additionally, infection control practices specific to this patient population are discussed. A comprehensive approach utilizing each of these can be effective at reducing the negative impact of viral infections. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Sour... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5421648 Fri, 18 Nov 2011 05:00:00 +0100 5421648 http://www.medworm.com/index.php?rid=5407219&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.24009 AbstractWe prospectively evaluated vascular endothelial growth factor (VEGF) expression by immunohistochemistry in 22 consecutive IRSS stage III retinoblastoma patients who underwent enucleation after neoadjuvant chemotherapy (NACT). Positive VEGF expression was observed in 6/22 (27.3%) patients. VEGF expression was associated with local progression on MRI prior to enucleation (P = 0.004), pathological scleral (P = 0.023), and extra‐scleral tumor extension (P = 0.009). EFS for VEGF positive and negative patients was 0% and 56.25%, respectively (P = 0.0002). OS for VEGF positive patients was 33.33% and 54.69% for VEGF negative patients (P = 0.207). Thus, VEGF in residual tumor cells post‐NACT may represent poor response to NACT, potential for local invasion, and infe... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5407219 Wed, 16 Nov 2011 16:39:46 +0100 5407219 http://www.medworm.com/index.php?rid=5400094&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23367 AbstractCannabis sativa has been used since antiquity to treat many ailments, including eating disorders. The primary psychoactive constituent of this plant, Δ9‐tetrahydrocannabinol (THC) is an FDA approved medication to treat nausea and emesis caused by cancer chemotherapeutic agents as well as to stimulate appetite in AIDS patients suffering from cachexia. The effects of THC are mediated through the endocannabinoid system (ECS), which promotes a positive energy balance through stimulation of appetite as well as shifting homeostatic mechanisms toward energy storage. Here we discuss the physiological function of the ECS in energy balance and the therapeutic potential of targeting this system. Pediatr Blood Cancer 2012; 58: 144–148. © 2011 Wiley Periodicals, Inc. (Source: Pediatric Bl... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5400094 Sun, 13 Nov 2011 01:35:30 +0100 5400094 http://www.medworm.com/index.php?rid=5400093&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23373 AbstractEpidemiologic studies have established that cardiovascular (CV) risk factors including obesity are identifiable in childhood. Childhood risk factors are predictive of adult cardiac risk and even premature death [Franks et al. (2010) N Engl J Med 362:485–493]. In the United States, CV diseases remains the leading causes of death. In fact, heart disease has become the major cause of death worldwide, surpassing undernutrition and infectious diseases, largely related to obesity in childhood [Wang and Lobstein (2006) Int J Pediatr Obes 1:11–25]. The concept that adult heart diseases begin in childhood is an outgrowth of extensive long‐term epidemiologic studies in youth, that is, the Bogalusa Heart Study [Berenson et al. (1986) Causation of cardiovascular risk factors in children:... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5400093 Sun, 13 Nov 2011 01:35:24 +0100 5400093 http://www.medworm.com/index.php?rid=5384658&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23308 ConclusionsElevated INR values occur often in patients receiving warfarin while admitted to a tertiary care pediatric facility and modifiable risk factors exist for elevated INR values. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5384658 Wed, 09 Nov 2011 00:50:04 +0100 5384658 http://www.medworm.com/index.php?rid=5384667&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23364 AbstractThe PIM kinase inhibitor, SGI‐1776, was tested against the PPTP in vitro (1.0 nM–10 µM) and in vivo panels (148 mg/kg daily × 5 days for 3 weeks). SGI‐1776 exhibited cytotoxic activity in vitro with a median relative IC50 of 3.1 µM. SGI‐1776 induced significant differences in EFS distribution in vivo in 9 of 31 solid tumor xenografts and in 1 of 8 of the evaluable ALL xenografts. SGI‐1776 induced tumor growth inhibition meeting criteria for intermediate EFS T/C activity in 1 of 39 evaluable models. In contrast, SGI‐1776 induced complete responses of subcutaneous MV4;11 (B myeloid leukemia). Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5384667 Wed, 02 Nov 2011 04:00:00 +0100 5384667 http://www.medworm.com/index.php?rid=5384666&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23382 ConclusionsDiagnostic delay was independently associated with age and site of presentation, and points of first symptom detection, first healthcare contact, and first suspicion of malignancy. The broad range of clinical variables analyzed could only account in a small way for differences in delay times observed. While overall delay times were short, they did not influence disease stage at presentation and eventual outcome. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5384666 Wed, 02 Nov 2011 04:00:00 +0100 5384666 http://www.medworm.com/index.php?rid=5384665&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23389 ConclusionsGrowth retardation is a significant adverse effect of imatinib in children with CML. The failure to gain appropriate height was most discernible when imatinib was initiated in the prepubertal period. Etiology and remedial measures need to be investigated. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5384665 Wed, 02 Nov 2011 04:00:00 +0100 5384665 http://www.medworm.com/index.php?rid=5384664&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23390 ConclusionsPIV infection was most commonly diagnosed among pediatric cancer patients with RV infection and PIV infection led to significant pulmonary complications and direct mortality in immunocompromised children. Since there are no effective antiviral agents for PIV infection, precautionary infection control and early diagnosis are the only methods available to prevent the infection spread. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5384664 Wed, 02 Nov 2011 04:00:00 +0100 5384664 http://www.medworm.com/index.php?rid=5384662&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23392 ConclusionsExercise training, initiated at the time treatment begins, can protect against delayed‐onset anthracycline‐induced cardiotoxicity in adult rats that were treated with anthracyclines as juveniles. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5384662 Wed, 02 Nov 2011 04:00:00 +0100 5384662 http://www.medworm.com/index.php?rid=5384661&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23393 We describe a case of a patient with WAS and NHL in the pharynx, an atypical tumor site presentation. The patient was successfully treated with a reduced dose chemotherapy regimen plus anti‐CD20 monoclonal antibody. He is in complete remission 3 years from the start of treatment. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5384661 Wed, 02 Nov 2011 04:00:00 +0100 5384661 http://www.medworm.com/index.php?rid=5384660&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23394 We report three pediatric patients with relapsed AML who achieved a sustained remission with sorafenib. Further trials are necessary to understand the role of sorafenib in pediatric AML. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5384660 Wed, 02 Nov 2011 04:00:00 +0100 5384660 http://www.medworm.com/index.php?rid=5360016&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23384 ConclusionsThese findings suggest that early‐onset post‐HSCT HLH is a specific entity of HLH, and appropriate diagnosis and prompt management need to be established. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5360016 Mon, 31 Oct 2011 00:04:55 +0100 5360016 http://www.medworm.com/index.php?rid=5360023&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23377 We report two patients with IVS6+5G>A of WAS in a Korean family. The proband presented with classic WAS, whereas his maternal cousin had symptoms limited to XLT. Their mothers were proved to be carriers. The IVS6+5G>A mutation was reported to result in incomplete splicing of the donor site and typically associated with mild form of disease, XLT. Our observation of the intrafamilial variability of clinical manifestations of WAS further expands the genotype–phenotype correlations and suggests the presence of modifying genetic factors. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5360023 Fri, 28 Oct 2011 04:00:00 +0100 5360023 http://www.medworm.com/index.php?rid=5360022&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23379 (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5360022 Fri, 28 Oct 2011 04:00:00 +0100 5360022 http://www.medworm.com/index.php?rid=5360021&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23383 We present the case of a patient with t(17;19)(q22;p13) gene rearranged B‐cell precursor ALL whose lymphoblasts were found to have significant in vitro sensitivity to dasatinib. The patient tolerated the addition of dasatinib with combination therapy and remained in remission for over nine months until his recurrence. Therefore, future studies will be needed to interrogate whether dasatinib has any therapeutic benefit in children with t(17;19) B‐cell precursor ALL. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5360021 Fri, 28 Oct 2011 04:00:00 +0100 5360021 http://www.medworm.com/index.php?rid=5360020&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23385 AbstractInvestigations of long‐term outcomes have been instrumental in designing safer and more effective contemporary therapies for pediatric hematological malignancies. Despite the significant therapeutic changes that have occurred over the last five decades, therapy modifications largely represent refinements of treatment protocols using agents and modalities that have been available for more than 30 years. This review summarizes major trends in the evolution of treatment of pediatric hematological malignancies since 1960 to support the relevance of the study of late effects of historical therapeutic approaches to the design and evaluation of contemporary treatment protocols and the follow‐up of present‐day survivors. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: P... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5360020 Fri, 28 Oct 2011 04:00:00 +0100 5360020 http://www.medworm.com/index.php?rid=5360019&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23386 The objective of this review was to comprehensively summarize existing studies utilizing validated instruments to measure psychosocial outcomes among bereaved parents of children with cancer. This population has increased risks of anxiety, depression, prolonged grief, and poor quality of life. Parental morbidity is associated with psychiatric co‐morbidities, prior loss, economic hardship, duration, and intensity of child's cancer‐therapy, perceptions of medical care, child's quality of life, preparedness for and location of the child's death. Rigorous, prospective research is needed to identify risk‐groups, define outcomes, and design interventions which will improve parental outcomes after the death of a child due to cancer. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc (Sourc... Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5360019 Fri, 28 Oct 2011 04:00:00 +0100 5360019 http://www.medworm.com/index.php?rid=5360018&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23387 ConclusionsInfantile myofibromatosis is a rare soft tissue tumor mainly concerning infants. Surgery is the treatment of choice for solitary forms when excision is possible. Close follow‐up may be proposed in the case of inoperable sites. In multicentric life‐threatening forms, chemotherapy promotes tumor regression and the vinblastine and methotrexate combination is effective with few long‐term adverse effects. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5360018 Fri, 28 Oct 2011 04:00:00 +0100 5360018 http://www.medworm.com/index.php?rid=5360017&cid=s_33611_6_f&fid=33611&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpbc.23388 ConclusionsPediatric VTE is most commonly seen in tertiary care. Adolescents are at greatest risk to develop in‐hospital VTE. Patients whose hospitalization ended with death are at much greater risk to develop VTE. Pediatr Blood Cancer © 2011 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer) Pediatric Blood and Cancer journals http://www.medworm.com/rss/comments.php?id=5360017 Fri, 28 Oct 2011 04:00:00 +0100 5360017