Pediatric Diabetes via MedWorm.com MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Pediatric Diabetes' source. Wed, 08 Feb 2012 15:09:02 +0100 Use of continuous glucose monitoring in children and adolescents http://www.medworm.com/index.php?rid=5648741&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00849.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5648741 Wed, 01 Feb 2012 05:00:00 +0100 5648741 Erratum http://www.medworm.com/index.php?rid=5638896&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2012.00853.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5638896 Sun, 29 Jan 2012 19:41:09 +0100 5638896 List of Reviewers 2011 http://www.medworm.com/index.php?rid=5638895&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2012.00854.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5638895 Sun, 29 Jan 2012 19:41:07 +0100 5638895 Highlights from the 37th Annual Meeting for ISPAD, Miami http://www.medworm.com/index.php?rid=5638894&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00850.x Hi Cho Y, Besser REJ, Craig ME. Highlights from the 37th Annual Meeting for ISPAD, Miami.The 37th Annual Meeting for the International Society of Pediatric and Adolescent Diabetes was held in Miami Beach, Florida, USA. The meeting, titled ‘Possibilities for Prevention and Diabetes and its Complications’, attracted over 1000 delegates from 52 countries. Fifty‐six oral abstracts were presented, along with 294 posters, representing the diversity of research and clinical innovations in the field of pediatric and adolescent diabetes around the world. Abstracts to the Oral and Poster Sessions can be found in a recent supplement of Pediatric Diabetes (1). Here are some highlights from the plenary sessions, symposia, and oral presentations. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5638894 Sun, 29 Jan 2012 19:41:06 +0100 5638894 Contraception, and pregnancy in adolescents with type 1 diabetes: a review http://www.medworm.com/index.php?rid=5638893&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00825.x Codner E, Soto N, Merino PM. Review of puberty, contraception, and pregnancy in adolescents with type 1 diabetes.Adolescence is a critical period for girls with type 1 diabetes mellitus (T1D). Reproductive issues, such as menstrual abnormalities, risk of an unplanned pregnancy, and contraception, should be addressed during this phase of life. This paper reviews several reproductive issues that are important in the care of adolescents, including pubertal development, menstrual abnormalities, ovulatory function, reproductive problems, the effects of hyperglycemia, contraception, and treatment of an unplanned pregnancy.A review of the literature was conducted. A MEDLINE search January 1966 to March 2011 was performed using the following MESH terms: puberty, menarche, ovary, polycystic ovary s... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5638893 Sun, 29 Jan 2012 19:41:04 +0100 5638893 Growth differences between North American and European children at risk for type 1 diabetes http://www.medworm.com/index.php?rid=5609505&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00840.x Conclusions:There are regional differences in early childhood growth that are consistent with the higher incidence of T1D in Northern Europe and Canada as compared to Southern Europe. Our prospective study from birth will allow evaluation of relationships between growth and the emerging development of autoimmunity and progression to T1D by region in this at‐risk population of children. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5609505 Tue, 17 Jan 2012 05:00:00 +0100 5609505 Xanthomata and diabetes in an adolescent with familial dysbetalipoproteinemia 9 yr after valproate‐induced pancreatitis http://www.medworm.com/index.php?rid=5609504&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00843.x A 14‐yr‐old girl presented with eruptive xanthomata and hypertriglyceridemia. This rare presentation led to diagnoses of diabetes and familial dysbetalipoproteinemia. Type 1 diabetes is a common childhood illness often presenting in adolescence. However, this patient's past medical history revealed valproate‐induced severe acute pancreatitis with necrosis at the age of 5 yr. Diabetes, in this case, developed 9 yr later as a result of inadequate pancreatic tissue to support increasing insulin requirements during growth and adolescence. Diabetes was discovered only after the appearance of cutaneous eruptive xanthomata, which appeared due to the previously undiagnosed genetic dyslipidemia. Although the relationship between xanthomata, hypertriglyceridemia, and diabetes may be well known... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5609504 Tue, 17 Jan 2012 05:00:00 +0100 5609504 Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new‐onset type 1 diabetes patients http://www.medworm.com/index.php?rid=5495185&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00836.x Conclusions:C4A appears to associate with the protection of residual β‐cell function in new‐onset T1D; C4B is correlated with the end of disease remission at 9‐month post diagnosis. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5495185 Tue, 13 Dec 2011 05:00:00 +0100 5495185 Feasibility of prolonged continuous glucose monitoring in toddlers with type 1 diabetes http://www.medworm.com/index.php?rid=5495184&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00837.x Conclusion:More than 40% of very young children were able to safely use CGM on a near‐daily basis after 6 months. CGM demonstrated frequent hyperglycemic excursions, with a large variability in glucose readings. Although improvement in glycemic control was not detected in the group as a whole, parental satisfaction with CGM was high. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5495184 Tue, 13 Dec 2011 05:00:00 +0100 5495184 Increase in the incidence of type 1 diabetes in Israeli children following the Second Lebanon War http://www.medworm.com/index.php?rid=5495183&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00838.x Conclusions:For the first time in a large population, we found a positive association between the trauma of war and an increase in the incidence of type 1 diabetes in children and adolescents. The increase in incidence was not associated with genetic susceptibility to the disease. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5495183 Tue, 13 Dec 2011 05:00:00 +0100 5495183 Childhood onset diabetes posttransplant in a girl with TCF2 mutation http://www.medworm.com/index.php?rid=5609503&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00842.x We report a female patient with bilateral renal hypodysplasia and de novo heterozygous TCF2 gene mutation. At the age of 9 yr, she developed transient ketoacidosis immediately posttransplant, temporarily requiring insulin. During glucocorticoid tapering, impaired glucose tolerance persisted and overt insulin‐dependent diabetes mellitus developed 1 yr later. Pathogenic factors which might have played a role in the acceleration of diabetes were (i) switch from cyclosporine to tacrolimus, (ii) weight excess, and (iii) cytomegalovirus infection. TCF2 analysis might, therefore, be of interest in patients with congenital abnormalities of the kidney and the urinary tract in order to improve posttransplant management in terms of steroid and tacrolimus exposure. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5609503 Thu, 01 Dec 2011 05:00:00 +0100 5609503 A matter of fat: insulin resistance and oxidative stress http://www.medworm.com/index.php?rid=5598349&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00847.x Conclusions:Oxidative stress increases in obese children according the severity of IR, which could be linked to the development of comorbidities. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5598349 Thu, 01 Dec 2011 05:00:00 +0100 5598349 Incidence and modes of presentation of childhood type 1 diabetes mellitus in Malta between 2006 and 2010 http://www.medworm.com/index.php?rid=5495182&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00839.x Conclusion:In Malta, the number of children/adolescents with T1DM has been rising at a faster rate than expected, and a distinct shift to younger age at onset has been observed. DKA rate at presentation is still high in Maltese children. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5495182 Thu, 01 Dec 2011 05:00:00 +0100 5495182 FTO gene is related to obesity in Chilean Amerindian children and impairs HOMA‐IR in prepubertal girls http://www.medworm.com/index.php?rid=5477031&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00834.x ConclusionsIn summary, we confirm the association of the FTO gene single‐nucleotide polymorphism rs9939609 with obesity in Chilean Amerindian children. Furthermore we show an association between the risk allele (A) and insulin resistance‐related markers prepubertal obese girls. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5477031 Thu, 01 Dec 2011 05:00:00 +0100 5477031 Continuous glucose monitoring in children, adolescents, and adults with type 1 diabetes mellitus: analysis from the prospective DPV diabetes documentation and quality management system from Germany and Austria http://www.medworm.com/index.php?rid=5458392&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00835.x ConclusionsCGM is still rarely used in Germany and Austria. CGM use is associated with a significant reduction of HbA1c in adults but not in children. Hypoglycemic events were not reduced, irrespective of age. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5458392 Thu, 01 Dec 2011 05:00:00 +0100 5458392 HLA‐class II and class I genotypes among Japanese children with Type 1A diabetes and their families http://www.medworm.com/index.php?rid=5458393&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00833.x ConclusionsThis study demonstrated the characteristic association of HLA‐class II and class I genes with Type 1A diabetes among Japanese children. A TDT did not reveal the genomic imprinting of HLA‐class II and class I genes in Type 1A diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5458393 Tue, 29 Nov 2011 05:00:00 +0100 5458393 Proinsulin, GLP‐1, and glucagon are associated with partial remission in children and adolescents with newly diagnosed type 1 diabetes http://www.medworm.com/index.php?rid=5449935&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00812.x Conclusions: In type 1 diabetes, patients in partial remission have higher levels of proinsulin together with lower levels of GLP‐1 and glucagon compared to patients not in remission. In new onset type 1 diabetes proinsulin level may be a sign of better residual beta‐cell function. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5449935 Mon, 28 Nov 2011 08:02:38 +0100 5449935 Comprehensive molecular analysis of Japanese patients with pediatric‐onset MODY‐type diabetes mellitus http://www.medworm.com/index.php?rid=5387987&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00827.x Conclusion: In Japanese patients with pediatric‐onset MODY‐type diabetes, mutations in known genes were identified at a much higher frequency than previously reported for adult Asians. A fraction of mutation‐negative patients presented with insulin‐resistance and normal insulin‐secretory capacities resembling early‐onset type 2 diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5387987 Tue, 08 Nov 2011 05:00:00 +0100 5387987 Incidence, genetics, and clinical phenotype of permanent neonatal diabetes mellitus in northwest Saudi Arabia http://www.medworm.com/index.php?rid=5387986&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00828.x Conclusions: Al‐Madinah region has the highest reported incidence of PNDM worldwide. In this region with high consanguinity, PNDM has different genetic aetiology and in the majority of cases presents as a part of rare familial autosomal‐recessive syndrome rather than in isolation. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5387986 Tue, 08 Nov 2011 05:00:00 +0100 5387986 Markedly reduced rate of diabetic ketoacidosis at onset of type 1 diabetes in relatives screened for islet autoantibodies http://www.medworm.com/index.php?rid=5387985&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00829.x Conclusions: Screening for islet autoantibodies in children likely leads to earlier diabetes diagnosis resulting in less complications at diagnosis. However, no substantial benefit in the clinical outcome during the first 5 yr after diagnosis was observed. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5387985 Tue, 08 Nov 2011 05:00:00 +0100 5387985 Evaluation of 1,5‐anhydroglucitol, hemoglobin A1c, and glucose levels in youth and young adults with type 1 diabetes and healthy controls http://www.medworm.com/index.php?rid=5387984&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00830.x Conclusions: Youth and young adults with T1D demonstrate similar 1,5‐AG levels which are distinct from controls. 1,5‐AG assessment may provide unique information beyond that provided by HbA1c in the mid‐term assessment of glycemic control in young patients with T1D and HbA1c < 8%. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5387984 Tue, 08 Nov 2011 05:00:00 +0100 5387984 The convergence of type 1 and type 2 diabetes in childhood The accelerator hypothesis http://www.medworm.com/index.php?rid=5387983&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00831.x Wilkin TJ. The accelerator hypothesis.It seems likely that type 1 and type 2 diabetes lie at different points of the same spectrum, separated by the misunderstanding that one belongs to childhood and the other to adulthood. The spectrum is that of tempo – the rate at which beta cell function is lost over time. A combination of beta cell up‐regulation (insulin demand, largely determined by obesity) and the genetically‐determined immune response to it (‘autoimmunity’) determines tempo, ranging from slow to fast with every variant in between. There is good evidence that people who go on to develop type 1 (fast) diabetes are, like those who develop type 2 (slow diabetes), insulin resistant, and overwhelming evidence that body mass plays a key role. The prevention of type 1 diabetes m... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5387983 Tue, 08 Nov 2011 05:00:00 +0100 5387983 The fallacy of reduction http://www.medworm.com/index.php?rid=5387982&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00832.x Rewers M. The fallacy of reduction.The “accelerator hypothesis” has made a significant impact on research into the etiology of type 1 diabetes. Some, but not all prospective studies have confirmed a weak association between insulin resistance and faster progression to diabetes among persons with advanced islet autoimmunity. However, there is hardly any evidence that insulin resistance can cause development of islet autoimmunity, thus be responsible for the ongoing pandemic of type 1 diabetes in children. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5387982 Tue, 08 Nov 2011 05:00:00 +0100 5387982 Slow‐release insulin in cystic fibrosis patients with glucose intolerance: a randomized clinical trial http://www.medworm.com/index.php?rid=5387981&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00810.x Conclusions: Glargine treatment was well accepted and tolerated. No real efficacy in improving clinical and glycometabolic conditions was demonstrated. Further studies are necessary to test glargine at higher dosage and for a longer follow‐up period. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5387981 Tue, 08 Nov 2011 05:00:00 +0100 5387981 Which obese youth are at increased risk for type 2 diabetes? Latent class analysis and comparison with diabetic youth http://www.medworm.com/index.php?rid=5387988&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00792.x Conclusion: Currently recommended screening of obese youth by FPG is normal in 91.5%, but lacks further information to detect increased risk for youth‐onset T2D. Evaluation of obese youth by LCA identified one third (class 3) in whom the combination of higher levels of BMIz, HOMA‐IR, and family history suggests the greatest risk for T2D and targets them for further evaluation and intensive preventative management. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5387988 Thu, 03 Nov 2011 04:00:00 +0100 5387988 Twenty‐one years of prospective incidence of childhood type 1 diabetes in Hungary – the rising trend continues (or peaks and highlands?) http://www.medworm.com/index.php?rid=5387980&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00826.x Gyurus EK, Patterson C, Soltesz Gy and the Hungarian Childhood Diabetes Epidemiology Group. Twenty‐one years of prospective incidence of childhood type 1 diabetes in Hungary – the rising trend continues (or peaks and highlands?).The aim of this study was to examine secular trends in the incidence of type 1 diabetes in children aged 0–14 yr in Hungary over the period 1989–2009. Newly diagnosed children with type 1 diabetes aged 0–14 yr in Hungary were prospectively registered from 1989 to 2009. Primary ascertainment of cases was by prospective registration using hospital notifications. Case ascertainment was over 96% complete using the capture–recapture method. Standardized incidence rates were calculated and secular trends estimated using Poisson regression analysis. In Hungary... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5387980 Tue, 01 Nov 2011 04:00:00 +0100 5387980 Enteroviruses and causality of type 1 diabetes: how close are we? http://www.medworm.com/index.php?rid=5401181&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00790.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5401181 Thu, 20 Oct 2011 04:00:00 +0100 5401181 Partial ABCC8 gene deletion mutations causing diazoxide‐unresponsive hyperinsulinaemic hypoglycaemia http://www.medworm.com/index.php?rid=5297426&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00821.x Flanagan SE, Damhuis A, Banerjee I, Rokicki D, Jefferies C, Kapoor RR, Hussain K, Ellard S. Partial ABCC8 gene deletion mutations causing diazoxide‐unresponsive hyperinsulinaemic hypoglycaemia.Inactivating mutations in the pancreatic beta cell ATP‐sensitive potassium (KATP) channel genes are identified by sequencing in approximately 80% of patients with diazoxide‐unresponsive hyperinsulinaemic hypoglycaemia (HH). Genetic testing is clinically important as the mode of inheritance of a KATP channel mutation(s) provides information on the histological subtype. For example in patients with a single paternally inherited mutation a focal lesion is possible and once confirmed, the patient can undergo a curative lesionectomy. By contrast, recessive inheritance indicates diffuse disease, whic... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5297426 Fri, 07 Oct 2011 04:00:00 +0100 5297426 Creating a national register of childhood type 1 diabetes using routinely collected hospital data http://www.medworm.com/index.php?rid=5348376&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00815.x Conclusion: We were able to create a surrogate register of childhood diabetes based on national hospital admissions data, containing approximately 2300 cases/yr, and geo‐coded to a high resolution. For younger cases (0–9 yr) and more recent years (from 2000) these data will be a useful resource for epidemiological studies exploring the determinants of childhood diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5348376 Sat, 01 Oct 2011 04:00:00 +0100 5348376 Enteroviruses and causality of type 1 diabetes: how close we are? http://www.medworm.com/index.php?rid=5336707&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00790.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5336707 Sat, 01 Oct 2011 04:00:00 +0100 5336707 Review of puberty, contraception, and pregnancy in adolescents with type 1 diabetes http://www.medworm.com/index.php?rid=5315154&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00825.x Codner E, Soto N, Merino PM. Review of puberty, contraception, and pregnancy in adolescents with type 1 diabetes.Adolescence is a critical period for girls with type 1 diabetes mellitus (T1D). Reproductive issues, such as menstrual abnormalities, risk of an unplanned pregnancy, and contraception, should be addressed during this phase of life. This paper reviews several reproductive issues that are important in the care of adolescents, including pubertal development, menstrual abnormalities, ovulatory function, reproductive problems, the effects of hyperglycemia, contraception, and treatment of an unplanned pregnancy.A review of the literature was conducted. A MEDLINE search January 1966 to March 2011 was performed using the following MESH terms: puberty, menarche, ovary, polycystic ovary s... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5315154 Sat, 01 Oct 2011 04:00:00 +0100 5315154 KATP channel mutations in infants with permanent diabetes diagnosed after 6 months of life http://www.medworm.com/index.php?rid=5304952&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00824.x Conclusion: KATP channel mutations are an uncommon cause of diabetes in infants presenting after 6 months. However, given the potential clinical benefit from identifying a KATP channel mutation, we recommend that KATP mutation testing should be routinely extended to infants diagnosed up to 9 months. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5304952 Sat, 01 Oct 2011 04:00:00 +0100 5304952 Author Index http://www.medworm.com/index.php?rid=5297430&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.01819.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5297430 Sat, 01 Oct 2011 04:00:00 +0100 5297430 Poster Sessions http://www.medworm.com/index.php?rid=5297429&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.01818.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5297429 Sat, 01 Oct 2011 04:00:00 +0100 5297429 Oral Sessions http://www.medworm.com/index.php?rid=5297428&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.01817.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5297428 Sat, 01 Oct 2011 04:00:00 +0100 5297428 Invited Speakers http://www.medworm.com/index.php?rid=5297427&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.01816.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5297427 Sat, 01 Oct 2011 04:00:00 +0100 5297427 The glucokinase mutation p.T206P is common among MODY patients of Jewish Ashkenazi descent http://www.medworm.com/index.php?rid=5297425&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00822.x Conclusions: The high incidence of the mutant allele in GCK‐MODY patients of Jewish‐Ashkenazi descent suggests a founder effect. We propose that clinically identified GCK‐MODY patients of Jewish‐Ashkenazi origin be first tested for this mutation. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5297425 Sat, 01 Oct 2011 04:00:00 +0100 5297425 Infants of diabetic mothers: echocardiographic measurements and cord blood IGF‐I and IGFBP‐1 http://www.medworm.com/index.php?rid=5238527&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00811.x Conclusions: The opposing relationships between cord blood IGF‐I and IGFBP‐1 on the cardiac morphological measurements supporting their putative opposing roles in HCM seen in IDMs. Birth weight is the best predictor of hypertrophied IVS especially in infants born to suboptimally controlled diabetic mothers. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5238527 Tue, 20 Sep 2011 04:00:00 +0100 5238527 Genetic correlates of early accelerated infant growth associated with juvenile‐onset type 1 diabetes http://www.medworm.com/index.php?rid=5238526&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00813.x Conclusions/discussion: Non‐carriership of the IGF1*194 allele was positively associated with accelerated first year growth in both patients and siblings, independent of disease. This IGF1 variant may therefore contribute to increased first year growth, but cannot explain the association of first year growth with diabetes. An effect on growth of the INS‐VNTR was detected in healthy siblings, but not in patients, suggesting that disease supersedes a growth effect of INS‐VNTR. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5238526 Tue, 20 Sep 2011 04:00:00 +0100 5238526 Cardiovascular risk in pediatric type 1 diabetes: sex‐specific intima‐media thickening verified by automatic contour identification and analyzing systems http://www.medworm.com/index.php?rid=5238525&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00814.x Conclusions: On the basis of sex differences of cRFs and cIMT in pediatric T1D, the assessment of sex‐specific IMT percentiles facilitates a differentiated interpretation of subclinical atherosclerosis. The underlying diabetes and additional cRFs seem to be more important determinants of intima‐media thickening than age. To improve the comparability of IMT measurements of relevant studies, the international harmonization of IMT measurements should be aimed for. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5238525 Tue, 20 Sep 2011 04:00:00 +0100 5238525 Early‐onset, severe lipoatrophy in a patient with permanent neonatal diabetes mellitus secondary to a recessive mutation in the INS gene http://www.medworm.com/index.php?rid=5226744&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00809.x We describe a case of neonatal diabetes due to a homozygous mutation (c.3 G>T) at the INS gene, leading to lack of insulin expression and severe hyperglycemia from day one of life requiring permanent insulin replacement therapy. The genetic loss of endogenous insulin production likely led to lack of immune tolerance to insulin, with resultant autoantibody production against exogenous insulin and progressive immune‐mediated lipoatrophy at injection sites. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5226744 Tue, 13 Sep 2011 04:00:00 +0100 5226744 All glutathione forms are depleted in blood of obese and type 1 diabetic children http://www.medworm.com/index.php?rid=5226746&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00806.x Conclusions: Our findings consistently show in vivo evidence of glutathione depletion upon early onset of T1D and in obese children, thus evidencing glutathione as an early marker in these two metabolic conditions. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5226746 Mon, 12 Sep 2011 04:00:00 +0100 5226746 C‐peptide in the classification of diabetes in children and adolescents http://www.medworm.com/index.php?rid=5226745&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00807.x Conclusions: More than half of children with newly diagnosed diabetes have clinically important residual beta‐cell function. As the clinical diagnosis is not always straightforward, a random C‐peptide taken at diagnosis may help to classify diabetes. There is an obvious use for C‐peptide determinations to evaluate beta‐cell function in children with diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5226745 Mon, 12 Sep 2011 04:00:00 +0100 5226745 Validation of a self‐report version of the diabetes self‐management profile http://www.medworm.com/index.php?rid=5286261&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00823.x Wysocki T, Buckloh LM, Antal H, Lochrie A, Taylor A. Validation of a self‐report version of the diabetes self‐management profile.Inadequate treatment adherence impedes achievement of glycemic control targets in type 1 diabetes (T1D). Valid and reliable measurement of treatment adherence is a prerequisite to rigorous evaluation of pertinent interventions. The diabetes self‐management profile (DSMP), a structured interview measure of T1D adherence, is valid and reliable but it requires trained interviewers, it is labor intensive to administer and it is burdensome for research participants. We adapted the DSMP interview to create the DSMP‐self‐report questionnaire (DSMP‐SR) for completion by parents and youth ≥11 yr old. The DSMP‐SR was obtained during a cross‐sectional stud... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5286261 Thu, 01 Sep 2011 04:00:00 +0100 5286261 Type 2 diabetes in youth: are there racial differences in β‐cell responsiveness relative to insulin sensitivity? http://www.medworm.com/index.php?rid=5238524&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00820.x Conclusions: Racial differences in insulin secretion can be demonstrated with the clamp technique in obese adolescents with T2DM. Similar to non‐diabetic youth, AA adolescents with T2DM compared with their AW counterparts have an upregulated β‐cell function relative to IS, the reasons for which remain to be investigated. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5238524 Thu, 01 Sep 2011 04:00:00 +0100 5238524 Leptin for type 1 diabetes: coming onto stage to be (or not?) http://www.medworm.com/index.php?rid=5226743&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00797.x Oral EA. Leptin for type 1 diabetes: coming onto stage to be (or not?).The discovery of the adipocyte hormone leptin completely changed our view of energy metabolism. In addition, the discovery of leptin rapidly progressed to clinical development. After a decade of clinical studies, leptin appears not to be the magic bullet therapy for obesity; however, it has a robust role in rare human conditions characterized by its deficiency. Recent exciting work from the Unger laboratory suggests that leptin therapy may also have a potential role for the treatment of Type 1 diabetes. In this review we discuss the positive evidence why such an approach is worthwhile. In order to achieve this broad goal, we reviewed available literature and provided our interpretation of the evidence presented in the o... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5226743 Thu, 01 Sep 2011 04:00:00 +0100 5226743 The use of leptin as treatment for type 1 diabetes mellitus: counterpoint http://www.medworm.com/index.php?rid=5184629&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00796.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5184629 Wed, 31 Aug 2011 23:00:00 +0100 5184629 GAD autoantibody epitope pattern after GAD‐alum treatment in children and adolescents with type 1 diabetes http://www.medworm.com/index.php?rid=5132615&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00802.x Conclusions: GAD‐alum injections did not affect binding of GADA to SPS‐related epitopes, further supporting the safety of the treatment. There were no changes in GADA epitope specificity to the T1D‐related epitopes, except for a temporarily increased binding to one of the tested epitopes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5132615 Mon, 15 Aug 2011 23:00:00 +0100 5132615 Increased TLR2 expression in patients with type 1 diabetes: evidenced risk of microalbuminuria http://www.medworm.com/index.php?rid=5144521&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00794.x Conclusions: Increased mRNA expression of TLR2, MyD88, and pro‐inflammatory cytokines in leukocytes of patients with childhood onset type 1 diabetes indicates the development of a TLR2‐mediated pro‐inflammatory process, which may also be associated with an early inflammatory process in the kidney and the occurrence of microalbuminuria. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5144521 Sun, 31 Jul 2011 23:00:00 +0100 5144521 The effectiveness of Internet‐based blood glucose monitoring system on improving diabetes control in adolescents with type 1 diabetes http://www.medworm.com/index.php?rid=5132614&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00800.x Conclusions: An Internet‐based blood glucose monitoring system was not associated with improved glycemic control in adolescents with T1DM. Identification of a sub‐group of compliant subjects who may improve metabolic control by using this tool is needed. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5132614 Sun, 31 Jul 2011 23:00:00 +0100 5132614 Prediction model for the incidence and prevalence of type 1 diabetes in childhood and adolescence: evidence for a cohort‐dependent increase within the next two decades in Germany http://www.medworm.com/index.php?rid=5098380&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00799.x Conclusions: In comparison to observations made in the past, the risk of disease rises even faster than expected: The younger the child, the quicker the increase of the cohort‐age‐specific IR and the higher the risk for T1D during lifetime. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5098380 Sun, 31 Jul 2011 23:00:00 +0100 5098380 Erratum http://www.medworm.com/index.php?rid=5070451&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00805.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5070451 Thu, 28 Jul 2011 03:44:46 +0100 5070451 Expert opinion and clinical experience regarding patients with type 1 diabetes mellitus fasting on Yom Kippur http://www.medworm.com/index.php?rid=5070450&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00801.x Grajower MM, Zangen D. Expert opinion and clinical experience regarding patients with type 1 diabetes mellitus fasting on Yom Kippur.This commentary constitutes the opinions of the endocrinologists whose names are appended. The commentary is based on articles published in peer‐reviewed journals as listed in the cited references, as well as cumulative experience in treating patients with type 1 diabetes mellitus (T1DM). This commentary applies only to patients with T1DM, and does not apply to patients with type 2 DM who are being treated with insulin even though the principles may be similar. The recommendations outlined also do NOT apply to the pregnant woman with T1DM, who should not fast. Additionally, this commentary does not preclude an individual from directing any questions having ... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5070450 Thu, 28 Jul 2011 03:44:40 +0100 5070450 The exercise‐induced inflammatory and oxidative state paradox http://www.medworm.com/index.php?rid=5070449&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00804.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5070449 Thu, 28 Jul 2011 03:44:39 +0100 5070449 Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes http://www.medworm.com/index.php?rid=5064049&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00798.x Conclusions: African‐American adolescents and young adults with type 2 diabetes have increased vascular stiffness than age‐matched Caucasians. This process is mediated by different cardiovascular risk factors. These results suggest race‐specific risk factor modification may be helpful to prevent early cardiovascular disease in this high risk population. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5064049 Sun, 24 Jul 2011 23:00:00 +0100 5064049 HNF1B mutation in a Turkish child with renal and exocrine pancreas insufficiency, diabetes and liver disease http://www.medworm.com/index.php?rid=5040480&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00773.x Gonc EN, Ozturk BB, Haldorsen IS, Molnes J, Immervoll H, Ræder H, Molven A, Søvik O, Njølstad PR. HNF1B mutation in a Turkish child with renal and exocrine pancreas insufficiency, diabetes and liver disease.A small‐for‐gestational age female infant presented with bilateral hypoplastic kidneys at 3 months of age. She developed chronic renal insufficiency. Insulin‐requiring, non‐autoimmune diabetes was documented at 6 years of age. She had mild steatosis and iron deposition in the liver, and mal‐development of pancreas. Genetic studies revealed a heterozygous mutation (S148L) of the HNF1B gene, compatible with an HNF1B‐MODY phenotype (MODY5). This is the first case of HNF1B‐MODY reported from Turkey and represents a particularly severe phenotype of the disease. (Source: Pedi... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5040480 Sun, 17 Jul 2011 23:00:00 +0100 5040480 The progression from obesity to type 2 diabetes in Alström syndrome http://www.medworm.com/index.php?rid=4999647&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00789.x Conclusions: In ALMS the progression from the early onset obesity toward the impaired fasting glucose or impaired glucose tolerance and overt diabetes is mostly because of a progressive failure of β‐cell insulin secretion without any further worsening of insulin resistance with age, even in the presence of weight reduction. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4999647 Sat, 02 Jul 2011 23:00:00 +0100 4999647 Onset of type 1 diabetes mellitus in two patients with maturity onset diabetes of the young http://www.medworm.com/index.php?rid=4961815&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00788.x We report two patients affected by MODY who developed T1DM. Case 1: a 4‐yr‐old girl referred for glycosuria presented hemoglobin A1c (HbA1c) of 6.6%. Islet cell antibodies (ICA) and anti‐glutamic acid decarboxylase (GADA) were initially negative. As her father, uncle and grandmother showed mild hyperglycemia, they were screened for MODY 2. A novel mutation in glucokinase gene was found in the family. Few months later, her glycemic control worsened consistently and she required insulin treatment. A high titer of GADA and ICA was then detected. Six years afterwards insulin requirement is 0.8 U/kg and HbA1c 6.7%. Case 2: a 15‐yr‐old boy treated for growth hormone deficiency was found with a blood glucose level of 106 mg/dL. HbA1c was 7.2%, ICA and GADA were negative. Family history ... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4961815 Wed, 22 Jun 2011 23:00:00 +0100 4961815 Diet, physical, and biochemical characteristics of children and adolescents with type 1 diabetes: relationship between dietary fat and glucose control http://www.medworm.com/index.php?rid=4938241&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00781.x Conclusions: Youth with T1D having regular nutritional counseling had a diet closer to RDIs than controls and not different cardiovascular risk factors. High saturated fatty acid intake was associated with poor blood glucose control. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4938241 Mon, 13 Jun 2011 23:00:00 +0100 4938241 Cerebral effects of severe hypoglycemia in young people with type 1 diabetes http://www.medworm.com/index.php?rid=5064048&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00803.x Bjørgaas MR. Cerebral effects of severe hypoglycemia in young people with type 1 diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5064048 Tue, 31 May 2011 23:00:00 +0100 5064048 Validation of classification algorithms for childhood diabetes identified from administrative data http://www.medworm.com/index.php?rid=5040479&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00795.x Conclusions: Demographic characteristics in combination with drug‐utilization patterns can be used to differentiate diabetes type among cases of pediatric diabetes identified within administrative health databases. Validation of similar algorithms in other regions is warranted. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=5040479 Tue, 31 May 2011 23:00:00 +0100 5040479 Effectiveness of sensor‐augmented pump therapy in children and adolescents with type 1 diabetes in the STAR 3 study http://www.medworm.com/index.php?rid=4999646&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00793.x Conclusions: SAP therapy allows both children and adolescents with marginally or inadequately controlled type 1 diabetes to reduce A1C values, hyperglycemic excursions, and glycemic variability in a rapid, sustainable, and safe manner. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4999646 Tue, 31 May 2011 23:00:00 +0100 4999646 Evaluation of a combined blood glucose monitoring and gaming system (Didget®) for motivation in children, adolescents, and young adults with type 1 diabetes* http://www.medworm.com/index.php?rid=4961814&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00791.x In conclusion, the Didget® system was precise and clinically accurate in the hands of children, adolescents, and young adults with type 1 diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4961814 Tue, 31 May 2011 23:00:00 +0100 4961814 Quality of life in children with diabetes and celiac disease: minimal impact of the ‘double diagnosis' http://www.medworm.com/index.php?rid=4938240&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00785.x Conclusions: The additional diagnosis of CD has minimal impact on quality of life in children with T1D; however, parents of CD + T1D children did express greater concern about their child's social functioning. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4938240 Tue, 31 May 2011 23:00:00 +0100 4938240 Changes in cardiometabolic risk factors, appetite‐controlling hormones and cytokines after a treatment program in overweight adolescents: preliminary findings from the EVASYON study http://www.medworm.com/index.php?rid=4864875&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00753.x Conclusions: These preliminary results evidence that the EVASYON program may improve body fat, leptin, and some pro‐inflammatory cytokines in adolescents with OW/OB. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4864875 Thu, 26 May 2011 16:43:26 +0100 4864875 The concerns of school staff in caring for children with diabetes in primary school http://www.medworm.com/index.php?rid=4843288&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00780.x Conclusions: Increased training for teachers having direct and current responsibility for children with diabetes was thought to lessen anxiety. Greater and more accessible knowledge about diabetes for all staff was requested. A range of practical management strategies were highlighted, including fostering good communication and teamwork between child, parent, school, and HCP. Professionals felt that support services would improve by using community‐based dieticians and including psychological input into the diabetes team. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4843288 Wed, 18 May 2011 23:00:00 +0100 4843288 Prevalence and characteristics of diabetes among Somali children and adolescents living in Helsinki, Finland http://www.medworm.com/index.php?rid=4843287&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00783.x Conclusions: These data show that (i) Somali children have autoimmune diabetes, (ii) the prevalence of T1D is similar among Somali and Finnish children, and (iii) both affected and unaffected Somali children have low concentrations of S25(OH)D. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4843287 Wed, 18 May 2011 23:00:00 +0100 4843287 Depressive symptoms predict change in glycemic control in adolescents with type 1 diabetes: rates, magnitude, and moderators of change http://www.medworm.com/index.php?rid=4814463&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00771.x Conclusions: Results suggest that depressive symptoms are important predictors of A1c change by themselves as well as when considered with adherence to BGM. There is a need to screen for depressive symptoms and expand and develop prevention and intervention strategies in order to put adolescents with type 1 diabetes in the best position for optimal glycemic control. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4814463 Wed, 11 May 2011 23:00:00 +0100 4814463 Impact of videogame playing on glucose metabolism in children with type 1 diabetes http://www.medworm.com/index.php?rid=4814462&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00770.x Phan‐Hug F, Thurneysen E, Theintz G, Ruffieux C, Grouzmann E. Impact of videogame playing on glucose metabolism in children with type 1 diabetes.Time spent playing videogames (VG) occupies a continually increasing part of children's leisure time. They can generate an important state of excitation, representing a form of mental and physical stress. This pilot study aimed to assess whether VG influences glycemic balance in children with type 1 diabetes. Twelve children with type 1 diabetes were subjected to two distinct tests at a few weeks interval: (i) a 60‐min VG session followed by a 60‐min rest period and (ii) a 60‐min reading session followed by a 60‐min rest period. Heart rate, blood pressure, glycemia, epinephrine (E), norepinephrine (NE), cortisol (F), and growth hormone (... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4814462 Wed, 11 May 2011 23:00:00 +0100 4814462 Basal rates and circadian profiles in continuous subcutaneous insulin infusion (CSII) differ for preschool children, prepubertal children, adolescents and young adults http://www.medworm.com/index.php?rid=4790569&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00777.x Conclusions: Age of the patient is the primary factor that influences both total daily requirement and circadian distribution of basal insulin in CSII. Experience from a large database may therefore facilitate the initiation of pump therapy in pediatric patients. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4790569 Wed, 04 May 2011 23:00:00 +0100 4790569 Behavioral research in pediatric diabetes: putting the evidence to work for advocacy and education* http://www.medworm.com/index.php?rid=4790568&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00778.x Anderson BJ. Behavioral research in pediatric diabetes: putting the evidence to work for advocacy and education. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4790568 Wed, 04 May 2011 23:00:00 +0100 4790568 The importance of different immunosuppressive regimens in the development of posttransplant diabetes mellitus http://www.medworm.com/index.php?rid=4843286&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00782.x Prokai A, Fekete A, Pasti K, Rusai K, Banki NF, Reusz G, Szabo AJ. The importance of different immunosuppressive regimens in the development of posttransplant diabetes mellitus. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4843286 Sat, 30 Apr 2011 23:00:00 +0100 4843286 The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants http://www.medworm.com/index.php?rid=4814461&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00774.x Conclusions: Different low‐cost and low‐resolution genotyping methods are useful for the efficient and accurate identification of a high‐risk cohort for follow‐up based on the TEDDY HLA inclusion criteria (ClinicalTrials.gov NCT00279318). (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4814461 Sat, 30 Apr 2011 23:00:00 +0100 4814461 Methylmalonic acidemia mimicking diabetic ketoacidosis in an infant http://www.medworm.com/index.php?rid=4790567&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00784.x We report an infant with MMA presented with diabetes symptoms. A 13‐month‐old girl complained of polydipsia, diuresis, and loss of weight. She had clinical signs of diabetic ketoacidosis such as dehydration, deep sighing respiration, smell of ketones, lethargy, and vomiting. Laboratory analysis showed hyperglycemia with acidosis and ketonuria. She was treated with parenteral fluid, electrolyte, and insulin infusion. Two days after her discharge, after having a meal rich in protein, she was brought unconscious with hepatomegaly, severe acidosis, ketonuria, and mild hyperammonemia. The absence of hyperglycemia and the presence of neurologic findings suggested organic acidemia. MMA was diagnosed because of methylmalonic aciduria and elevated C3 carnitine esters. Cranial magnetic resonance... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4790567 Sat, 30 Apr 2011 23:00:00 +0100 4790567 Familial occurrence of neonatal diabetes with duplications in chromosome 6q24: treatment with sulfonylurea and 40‐yr follow‐up http://www.medworm.com/index.php?rid=4748975&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00776.x We present a Norwegian family, followed since 1967, with a chromosome 6q24 duplication in two siblings with neonatal diabetes, in their non‐diabetic father, and in a female (third generation) with adult‐onset diabetes. The parents (first generation) were healthy and non‐consanguineous. After a miscarriage, the couple had two infants with birth weights of 1780 and 1620 g, respectively, both of whom died on their second day of life. Patient I (male, weight 1840 g at term) had a blood glucose level of 33 mmol/L on day 6. He was treated with insulin for 3 months. In adult life he had permanent diabetes, treated with oral hypoglycemic agents. At 43 yr of age, there were no diabetic late complications. Patient II (female, birth weight 1440 g at term) had an increasing blood glucose of 55 m... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4748975 Tue, 26 Apr 2011 14:31:09 +0100 4748975 Preliminary studies related to anti‐interleukin‐1β therapy in children with newly diagnosed type 1 diabetes http://www.medworm.com/index.php?rid=4748976&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00761.x Conclusions: Anakinra therapy is well tolerated in children with newly diagnosed type 1 diabetes. Further studies are needed to demonstrate biological effects. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4748976 Sat, 23 Apr 2011 23:00:00 +0100 4748976 Predictors of diabetic ketoacidosis in children and adolescents with type 1 diabetes. Experience from a large multicentre database http://www.medworm.com/index.php?rid=4686948&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00728.x Conclusion: In a cohort of European paediatric diabetic patients, the rate of DKA was significantly higher in females and in children with migration background and early teenage years. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4686948 Tue, 05 Apr 2011 23:00:00 +0100 4686948 Acute cerebral infarction and extra pontine myelinolysis in children with new onset type 1 diabetes mellitus http://www.medworm.com/index.php?rid=4686947&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00732.x We report on two children who suffered from acute cerebral infarction (CI) and extra pontine myelinolysis (EPM) at onset of type 1 diabetes. Initially, clinical management had not been performed according to generally accepted guidelines. Putative risk factors that may have predisposed for the development of acute cerebrovascular complications are discussed. Not only cerebral edema (CE) but also other severe neurological complications such as CI should be suspected when neurological deterioration occurs during DKA. We conclude that not only an exceeded rehydration therapy but also a rapidly reduced serum osmolality due to an unbalanced rapid blood sugar decrease and serum sodium increase may have lead to the neurological disease. We propose that a reserved and well‐defined rehydration st... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4686947 Tue, 05 Apr 2011 23:00:00 +0100 4686947 Poor adherence to integral daily tasks limits the efficacy of CSII in youth http://www.medworm.com/index.php?rid=4686946&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00740.x Conclusions: Glycemic advantage obtained with CSII regimens is closely related to the manner in which CSII is employed. Poor adherence to integral CSII‐related tasks is frequently encountered in adolescents and limits the efficacy of CSII in these youth. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4686946 Tue, 05 Apr 2011 23:00:00 +0100 4686946 One‐hour plasma glucose concentration during the OGTT: what does it tell about β‐cell function relative to insulin sensitivity in overweight/obese children? http://www.medworm.com/index.php?rid=4686945&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00745.x Conclusions: Overweight/obese youth with 1‐h glucose ≥155 mg/dL during the oral glucose tolerance test have a significantly lower β‐cell function relative to insulin sensitivity even within the normal glucose tolerance range. Such youth may be at higher risk of future diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4686945 Tue, 05 Apr 2011 23:00:00 +0100 4686945 Asthma and allergic symptoms and type 1 diabetes‐related autoantibodies in 2.5‐yr‐old children http://www.medworm.com/index.php?rid=4686944&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00758.x Wahlberg J, Vaarala O, Ludvigsson J, for the ABIS Study Group. Asthma and allergic symptoms and type 1 diabetes‐related autoantibodies in 2.5‐yr‐old children.A dominance of Th2 cytokine pattern is associated with allergic diseases, whereas a Th1 pattern has been reported in autoimmune type 1 diabetes (T1D). The Th1/Th2 paradigm has led to the interest in the relationship between these diseases. To investigate the association between atopic diseases, asthma and occurrence of T1D‐related β‐cell autoantibodies in children, we studied 7208 unselected 2.5‐yr‐old children from the All Babies in Southeast Sweden (ABIS) cohort. The ABIS cohort includes 17 055 (78.3% out of all 21 700) children born from October 1997 to October 1999, and followed prospectively with regular biological... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4686944 Tue, 05 Apr 2011 23:00:00 +0100 4686944 The growth hormone receptor (GHR) exon 3 polymorphism and its correlation with metabolic profiles in obese Chinese children http://www.medworm.com/index.php?rid=4686943&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00747.x Conclusion: We report that the d3‐GHR polymorphism has a significant effect on BMI and the metabolic parameters of Chinese children with obesity. The d3 allele may have a protective effect on the development of metabolic syndrome by increasing insulin sensitivity. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4686943 Tue, 05 Apr 2011 23:00:00 +0100 4686943 Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents: the HELENA study http://www.medworm.com/index.php?rid=4686942&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00769.x Conclusion: Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents. These results support current physical activity recommendations for youth, which include muscle strengthening activities in addition to aerobic exercise. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4686942 Tue, 05 Apr 2011 23:00:00 +0100 4686942 The ALBA Project: an evaluation of needs, management, fears of Italian young patients with type 1 diabetes in a school setting and an evaluation of parents' and teachers' perceptions http://www.medworm.com/index.php?rid=4671969&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00722.x Conclusions: The study shows that people who are not directly involved have superficial knowledge of the different aspects of diabetes, even though no parents reported episodes of neglect/incorrect management. There is no legislation which clearly defines the role of the school in the care of children with T1D, and teachers are not trained to help them. Training sessions for school personnel and greater legislative clarity about the ‘insulin and glucagon question’ are key factors that may improve the full integration of the child with diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4671969 Sat, 02 Apr 2011 23:00:00 +0100 4671969 Assessing diabetes support in adolescents: factor structure of the Modified Diabetes Social Support Questionnaire (M‐DSSQ‐Family) http://www.medworm.com/index.php?rid=4645025&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00691.x Conclusion: The 40‐item M‐DSSQ‐Family presented a different view of traditional aspect of diabetes social support from family which may be more fruitful for adolescents. In addition, it emerged as a valid and reliable measure of family support for Dutch adolescents with type 1 diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645025 Mon, 28 Mar 2011 23:00:00 +0100 4645025 Infant anthropometry, early life infection, and subsequent risk of type 1 diabetes mellitus: a prospective birth cohort study http://www.medworm.com/index.php?rid=4645024&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00693.x Conclusion: In this cohort, early upper respiratory tract infection was associated with T1DM risk, as had been previously found for asthma, consistent with immunoinflammatory upregulation. Using the detailed anthropometric measures available, the link between higher birthweight and T1DM did not appear to reflect increased adiposity. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645024 Mon, 28 Mar 2011 23:00:00 +0100 4645024 Presentation and course of diabetes in children and adolescents with Alstrom syndrome http://www.medworm.com/index.php?rid=4645023&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00698.x Mokashi A, Cummings EA. Presentation and course of diabetes in children and adolescents with Alstrom syndrome.Alstrom syndrome is characterized by childhood obesity, progressive retinal degeneration, and sensorineural hearing loss with diabetes mellitus (DM) developing later in childhood and adulthood. The course of diabetes in children with this condition has not been described. We aim to describe the diagnosis, management, and course of diabetes in a series of children followed in our center. A retrospective chart review of all seven children with Alstrom syndrome was performed. Patients, aged 4.5–22 yr, had typical features of Alstrom syndrome. Five were diagnosed with DM at a median age of 11.5 yr. At diagnosis of DM, mean fasting blood glucose (FBG) was normal at 82.8 ± 12.6 mg/dL ... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645023 Mon, 28 Mar 2011 23:00:00 +0100 4645023 Clinical and metabolic effects of gluten free diet in children with type 1 diabetes and coeliac disease http://www.medworm.com/index.php?rid=4645022&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00700.x Conclusion: In our experience, GFD showed short‐term benefits by reducing GI symptoms and severe hypoglycaemia while the insulin requirement increased significantly. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645022 Mon, 28 Mar 2011 23:00:00 +0100 4645022 Cardiometabolic risk factors as apolipoprotein B, triglyceride/HDL‐cholesterol ratio and C‐reactive protein, in adolescents with and without obesity: cross‐sectional study in middle class suburban children http://www.medworm.com/index.php?rid=4645021&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00710.x Conclusions: Even when the frequency of OB, OW, and MS in adolescents was low, those subjects presented an atherogenic lipoprotein. These findings emphasize the importance to evaluate cardiovascular risk factors in adolescents to assess strategies to prevent future disease. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645021 Mon, 28 Mar 2011 23:00:00 +0100 4645021 Proinsulin and the proinsulin/insulin ratio in overweight and obese children and adolescents: relation to clinical parameters, insulin resistance, and impaired glucose regulation http://www.medworm.com/index.php?rid=4645020&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00734.x Conclusions: Children and adolescents with IGR have disproportionately elevated PI levels, both during fasting and after acute glucose stimulation indicating β‐cell dysfunction. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645020 Mon, 28 Mar 2011 23:00:00 +0100 4645020 Assessing readiness to change the balance of responsibility for managing type 1 diabetes mellitus: adolescent, mother, and father perspectives http://www.medworm.com/index.php?rid=4645019&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00737.x Conclusions: Individual assessment of youth and caregivers' readiness to change the balance of responsibility for diabetes management tasks may be beneficial to providers during the youths' transition from adolescence to young adulthood. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645019 Mon, 28 Mar 2011 23:00:00 +0100 4645019 Identification of self‐management patterns in pediatric type 1 diabetes using cluster analysis http://www.medworm.com/index.php?rid=4645018&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00752.x Conclusion: Our results objectively describe differences in patterns of self‐management in youth with type 1 diabetes, that relate to glycemic control. Interventions based on these specific patterns of self‐management may improve diabetes management and enhance glycemic control in children and adolescents with type 1 diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645018 Mon, 28 Mar 2011 23:00:00 +0100 4645018 Prospective evaluation of risk factors for the development of islet autoimmunity and type 1 diabetes during puberty – TEENDIAB: study design http://www.medworm.com/index.php?rid=4645017&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00763.x Anette‐Gabriele Ziegler, Franziska Meier‐Stiegen, Christiane Winkler, Ezio Bonifacio, the TEENDIAB Study Group. Prospective evaluation of risk factors for the development of islet autoimmunity and type 1 diabetes during puberty – TEENDIAB: study design.Type 1 diabetes (T1D) has a peak incidence in childhood and adolescence. The TEENDIAB study investigates the period of puberty and adolescence in the natural course of T1D development. Evidence suggests that the immune phenotype of children developing autoimmunity during puberty and adolescence differs from that in childhood. We hypothesize that these differences reflect heterogeneity in the genetic and environmental factors that influence the development of autoimmunity in puberty versus early infancy. TEENDIAB is an observational coh... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645017 Mon, 28 Mar 2011 23:00:00 +0100 4645017 Hypertension despite dehydration during severe pediatric diabetic ketoacidosis http://www.medworm.com/index.php?rid=4645032&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00695.x Conclusion: Despite dehydration, most children admitted with severe DKA had hypertension. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645032 Sun, 27 Mar 2011 23:00:00 +0100 4645032 Type 1 diabetes and perinatal factors in Catalonia (Spain)* http://www.medworm.com/index.php?rid=4645031&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00711.x Conclusions: Only being born LGA was significantly associated with developing type 1 diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645031 Sun, 27 Mar 2011 23:00:00 +0100 4645031 Diabetes‐specific emotional distress among adolescents: feasibility, reliability, and validity of the problem areas in diabetes‐teen version http://www.medworm.com/index.php?rid=4645030&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00720.x Weissberg‐Benchell J, Antisdel‐Lomaglio J. Diabetes‐specific emotional distress among adolescents: feasibility, reliability, and validity of the problem areas in diabetes‐teen version. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645030 Sun, 27 Mar 2011 23:00:00 +0100 4645030 Lower HbA1c after 1 year, in children with type 1 diabetes treated with insulin glargine vs. NPH insulin from diagnosis: a retrospective study http://www.medworm.com/index.php?rid=4645029&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00723.x Conclusions: HbA1c 1 yr from diagnosis was lower in children treated with glargine from start as compared with those on NPH. This observation should be viewed in the light of a significantly lower dose of total daily insulin in the glargine group. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645029 Sun, 27 Mar 2011 23:00:00 +0100 4645029 Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes http://www.medworm.com/index.php?rid=4645028&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00724.x Rosa JS, Oliver SR, Flores RL, Ngo J, Milne GL, Zaldivar FP, Galassetti PR. Altered inflammatory, oxidative, and metabolic responses to exercise in pediatric obesity and type 1 diabetes.Obesity (Ob) and type 1 diabetes (T1DM) are associated with increased inflammation and oxidative stress, which are major pathogenetic pathways toward higher cardiovascular risks. Although long‐term exercise protects against systemic inflammation and oxidation, acute exercise actually exerts pro‐inflammatory and oxidative effects, prompting the necessity for better defining these molecular processes in at‐risk patients; in particular, very little is known regarding obese and T1DM children. We therefore examined key inflammatory and oxidative stress variables during exercise in 138 peripubertal children... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645028 Sun, 27 Mar 2011 23:00:00 +0100 4645028 Effective treatment of hypoglycemia in children with type 1 diabetes: a randomized controlled clinical trial http://www.medworm.com/index.php?rid=4645027&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00725.x Conclusions: Jellybeans are less effective treatment for hypoglycemia than the other three treatments. Glucose tablets, Mentos dragees® and orange juice are of similar efficacy. Treatment with 0.3 g/kg of carbohydrate (excluding jellybeans) effectively resolved hypoglycemia in most children, with 15 min often required to normalize blood glucose. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645027 Sun, 27 Mar 2011 23:00:00 +0100 4645027 Association between the FTO gene and overweight in Japanese children and adolescents http://www.medworm.com/index.php?rid=4645026&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00727.x Conclusion: The FTO gene is associated with the early onset of overweight in the Japanese population as well as in European populations. The results suggest that obesity‐related risk factors in fifth and eighth graders appear because of their overweight status. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645026 Sun, 27 Mar 2011 23:00:00 +0100 4645026 Attained education and self‐assessed health later in life when diagnosed with diabetes in childhood: a population‐based study http://www.medworm.com/index.php?rid=4632570&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00757.x Conclusions: In terms of the rapid increase in the incidence of diabetes in many countries, it is important to bear in mind that investments made both in education and in health, early in life, may facilitate the capability of the individual to experience healthy time later in life. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4632570 Thu, 24 Mar 2011 00:00:00 +0100 4632570 Prevalence of intentional under‐ and overdosing of insulin in children and adolescents with type 1 diabetes http://www.medworm.com/index.php?rid=4632569&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00759.x Conclusion: Intentional overdosing of insulin is almost as prevalent in children and adolescents as insulin omission. Females are more at risk. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4632569 Thu, 24 Mar 2011 00:00:00 +0100 4632569 Erythrocyte membrane omega‐3 fatty acid levels and omega‐3 fatty acid intake are not associated with conversion to type 1 diabetes in children with islet autoimmunity: The Diabetes Autoimmunity Study in the Young (DAISY) http://www.medworm.com/index.php?rid=4632568&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00760.x Conclusions: In this observational study, omega‐3 fatty acid intake and status are not associated with conversion to type 1 diabetes in children with IA. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4632568 Thu, 24 Mar 2011 00:00:00 +0100 4632568 Obesity and type 2 diabetes mellitus in a birth cohort of First Nation children born to mothers with pediatric‐onset type 2 diabetes http://www.medworm.com/index.php?rid=4627911&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00694.x Conclusions: The prevalence of type 2 diabetes in this cohort of offspring of First Nation women with pediatric‐onset type 2 diabetes is the highest ever reported. Obesity is an important postnatal risk factor for type 2 diabetes in this population and may result from a unique gene–environment interaction. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4627911 Wed, 23 Mar 2011 00:00:00 +0100 4627911 Onset features and subsequent clinical evolution of childhood diabetes over several years http://www.medworm.com/index.php?rid=4623341&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00706.x Conclusions/interpretation: Ten percent of subjects had MDM and 15% had T2DM at ∼8 years' duration. Although no onset feature was completely reliable, ketoacidosis and hyperglycemia were more likely to predict T1DM; obesity and African American ethnicity made T2DM more likely. At diagnosis, features of T2DM in addition to obesity were strongly predictive of eventual T2DM phenotype. Given the significant percentage who changed or had mixed phenotype, careful tracking of all young people with diabetes is essential to correctly determine eventual disease type. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4623341 Wed, 23 Mar 2011 00:00:00 +0100 4623341 High HOMA‐IR, adjusted for puberty, relates to the metabolic syndrome in overweight and obese Chilean youths http://www.medworm.com/index.php?rid=4623343&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00685.x Conclusions: In a large clinical sample of overweight and obese Chilean youths, HOMA‐IR ≥75th percentile was significantly associated with the cluster of factors referred to as the MetS. We emphasize the importance of establishing percentiles for HOMA‐IR based on a normative sample and taking Tanner stage into account. Although BMI is easy to assess and interpret with minimal costs in a clinical setting, adding HOMA‐IR explains more of the variance in the MetS than BMI Z‐score alone. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4623343 Tue, 22 Mar 2011 00:00:00 +0100 4623343 Parathormone – 25(OH)‐vitamin D axis and bone status in children and adolescents with type 1 diabetes mellitus http://www.medworm.com/index.php?rid=4623342&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00739.x Conclusions: Children and adolescent with T1DM have abnormal bone status mostly in axial skeleton which may be contributed to impairment of formation of 25(OH)D and IGF‐1. Physical activity, calcium and vitamin D supplement seem important in T1DM. Elevated serum PTH level in diabetic patients is not uncommon and its positive correlation with bone status needs further investigations. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4623342 Tue, 22 Mar 2011 00:00:00 +0100 4623342 HLA‐DQ haplotypes differ by ethnicity in patients with childhood‐onset diabetes http://www.medworm.com/index.php?rid=4617127&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00712.x Conclusions: Fifty‐nine percent of childhood‐onset patients with T1DM were identified with high genetic risk based on known HLA‐DQA1/B1 associations. Many non‐Caucasian patients carry HLA‐DQ alleles whose association with T1DM is undetermined. Genetic approaches can provide insights into the etiology and appropriate treatment of childhood‐onset diabetes but only if sufficient data are available in diverse ethnic groups. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4617127 Mon, 21 Mar 2011 00:00:00 +0100 4617127 Treatment with insulin detemir or NPH insulin in children aged 2–5 yr with type 1 diabetes mellitus http://www.medworm.com/index.php?rid=4617126&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00750.x In conclusion, long‐term treatment with IDet in children aged 2–5 yr suggested similar glycaemic control, greater reduction in FPG, lower rates of hypoglycaemia, no inappropriate weight gain, and fewer adverse events compared with NPH. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4617126 Mon, 21 Mar 2011 00:00:00 +0100 4617126 Prevalence of type 1 diabetes mellitus in 6–18‐yr‐old school children living in Istanbul, Turkey http://www.medworm.com/index.php?rid=4617125&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00744.x Conclusion: This first pediatric T1DM prevalence data in a large pediatric population in Istanbul, Turkey, estimated the prevalence of T1DM as 0.67/1000. This prevalence is 2.5‐fold higher than that reported in Ankara, Turkey, in 1993, suggesting that T1DM prevalence is increasing in Turkey as in the other parts of the world. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4617125 Mon, 21 Mar 2011 00:00:00 +0100 4617125 High incidence of childhood type 1 diabetes in Al‐Madinah, North West Saudi Arabia (2004–2009) http://www.medworm.com/index.php?rid=4617124&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00765.x Conclusions: Al‐Madinah city has the highest reported incidence of childhood T1DM in the Middle East and North Africa region. Further studies to identify the reasons for this high incidence are needed. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4617124 Mon, 21 Mar 2011 00:00:00 +0100 4617124 P300 auditory event‐related potentials in children with obesity: is childhood obesity related to impairment in cognitive functions? http://www.medworm.com/index.php?rid=4617123&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00748.x Conclusion: Both decreased amplitude and prolonged latency of P300 are associated with IR in children with obesity, which shows the impairment of neural activity associated with sensory and cognitive information processing in these children. Further studies are necessary to strengthen the current findings and to determine the exact mechanism of cognitive impairment in obese children. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4617123 Mon, 21 Mar 2011 00:00:00 +0100 4617123 Young patients with both type 1 diabetes mellitus and asthma have a unique IL‐12 and IL‐18 secretory pattern http://www.medworm.com/index.php?rid=4617122&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00751.x Conclusion: Patients with both T1DM and asthma display a different pattern of IL‐12 and IL‐18 expression compared to patients with one disease only and controls. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4617122 Mon, 21 Mar 2011 00:00:00 +0100 4617122 Gender differences in the relationship between parental report of self‐regulation skills and adolescents' management of type 1 diabetes http://www.medworm.com/index.php?rid=4571804&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00692.x Conclusion: For adolescent boys, the ability to cope with various stressors and emotions may be as important as higher‐order thinking skills for maximizing treatment adherence and diabetes control. Clinical implications and potential mechanisms by which emotion regulation skills relate to adolescent boys' diabetes treatment management are discussed. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4571804 Fri, 11 Mar 2011 00:00:00 +0100 4571804 Blood glucose monitoring and glycemic control in adolescents with type 1 diabetes: meter downloads versus self‐report http://www.medworm.com/index.php?rid=4571803&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00735.x Conclusions: Meter downloads have the most robust association with glycemic control when contextual variables are considered. Caregiver‐reported BGM frequencies can serve as reliable substitutes in the absence of meter download, but they may not be as reliable in adolescents with depressive symptoms. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4571803 Fri, 11 Mar 2011 00:00:00 +0100 4571803 A longitudinal assessment of lipids in youth with type 1 diabetes http://www.medworm.com/index.php?rid=4571802&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00733.x Conclusion: Glycemic control and BMI are modifiable risk factors for dyslipidemia in youth with type 1 diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4571802 Fri, 11 Mar 2011 00:00:00 +0100 4571802 Associations between periodontal disease and selected risk factors of early complications among youth with type 1 and type 2 diabetes: a pilot study http://www.medworm.com/index.php?rid=4571801&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00736.x Conclusions: The associations between periodontal disease and risk factors for diabetes complications differ by diabetes type. Periodontal damage is associated with impaired beta cell function and metabolic syndrome components in type 2 but not type 1 diabetes. These findings need to be confirmed in larger, prospective studies. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4571801 Fri, 11 Mar 2011 00:00:00 +0100 4571801 Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents† http://www.medworm.com/index.php?rid=4541626&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00738.x Conclusions: The G‐allele of rs10830693 in the MTNR1B gene was significantly related to glucose levels, while an impact of this genetic variant on the changes in glucose metabolism in children participating in a lifestyle intervention was not observable. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4541626 Thu, 03 Mar 2011 00:00:00 +0100 4541626 Use of metformin in pediatric age http://www.medworm.com/index.php?rid=4541625&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00741.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4541625 Thu, 03 Mar 2011 00:00:00 +0100 4541625 The interrelationships of glycemic control measures: HbA1c, glycated albumin, fructosamine, 1,5‐anhydroglucitrol, and continuous glucose monitoring http://www.medworm.com/index.php?rid=4726004&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00764.x Conclusion: Each of the four measures (i.e., HbA1c, glycated albumin, fructosamine, and 1,5‐AG) had a similar correlation with mean glucose and hyperglycemic AUC‐180. 1,5‐AG did not correlate with hyperglycemic AUC‐180 better than did HbA1c. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4726004 Tue, 01 Mar 2011 00:00:00 +0100 4726004 Preferences for type 2 diabetes health states among adolescents with or at risk of type 2 diabetes mellitus http://www.medworm.com/index.php?rid=4705636&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00772.x Conclusions: Adolescents with or at risk of T2DM rated treatments and sequelae of diabetes as significantly worse than their parents. These adolescent utilities should be considered in the evaluation of treatment strategies for youth with T2DM. Family‐based programs for T2DM must also be prepared to address conflicting preferences in order to promote shared decision‐making. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4705636 Tue, 01 Mar 2011 00:00:00 +0100 4705636 Insulin delivery by injection in children and adolescents with diabetes http://www.medworm.com/index.php?rid=4698882&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00731.x Hanas R, de Beaufort C, Hoey H, Anderson B. Insulin delivery by injection in children and adolescents with diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4698882 Tue, 01 Mar 2011 00:00:00 +0100 4698882 Acute juvenile cataract in newly diagnosed type 1 diabetic patients: a description of six cases http://www.medworm.com/index.php?rid=4686941&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00749.x Iafusco D, Prisco F, Romano MR, Dell’Omo R, Libondi T, Costagliola C. Acute juvenile cataract in newly diagnosed type 1 diabetic patients: a description of six cases.Cataract represents one of the most frequent eye complications in type 1 and type 2 patients; contrarily, acute cataract in young diabetic patients occurs very rarely. The aim of this study was to describe six cases of acute cataract in adolescents at the onset of type 1 diabetes. Eight hundred and twenty‐six patients with type 1 diabetes were retrospectively studied. A multivariate analysis was applied to verify the weight of the following laboratory findings taken on admission (independent variables): glycemia, glycated hemoglobin (HbA1c), pH, base excess (BE),and on the occurrence of cataract (dependent variable). Six p... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4686941 Tue, 01 Mar 2011 00:00:00 +0100 4686941 Prescribed regimen intensity in diverse youth with type 1 diabetes: role of family and provider perceptions http://www.medworm.com/index.php?rid=4671968&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00766.x In this study, we examined racial/ethnic differences in regimen intensity and predictors of regimen intensity in youth with type 1 diabetes. We expected that minority youth would have less intensive regimens and that caregiver and physician perceptions would be associated with regimen intensity. This cross‐sectional study included 178 families of 10‐ to 17‐yr‐old youth at three endocrinology clinics. Caregivers reported perceived costs and benefits of intensive regimens. Physicians described the prescribed treatment and their perceptions of family/child competence and self‐management. Analyses included analysis of covariance and hierarchical multiple linear regression. Findings indicate a disparity in regimen intensity for minority youth. Caregiver perceptions of costs associated... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4671968 Tue, 01 Mar 2011 00:00:00 +0100 4671968 Sweet sins: frequency and psychiatric motivation for theft among adolescents with type 1 diabetes http://www.medworm.com/index.php?rid=4654613&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00721.x Conclusions: Theft may be a factor negatively affecting metabolic control in children with T1D and underlying psychiatric co‐morbidity. Psychiatric morbidity is more frequent among patients with T1D and a history of theft. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4654613 Tue, 01 Mar 2011 00:00:00 +0100 4654613 Clinical utility of Abbott Precision Xceed Pro® ketone meter in diabetic patients http://www.medworm.com/index.php?rid=4645016&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00768.x Conclusions: BOH measurements by the Abbott meter up to 3 mmol/L correlate well with the reference method, but become discrepant above that point. While this characteristic may be useful in the diagnosis of DKA, it may not allow clinicians to serially follow the response to therapy in hospitalized DKA patients with BOH values greater than 5 mmol/L (reference method). (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4645016 Tue, 01 Mar 2011 00:00:00 +0100 4645016 Microvascular complications assessment in adolescents with 2‐ to 5‐yr duration of type 1 diabetes from 1990 to 2006 http://www.medworm.com/index.php?rid=4632567&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00762.x Conclusions: Early complications are not uncommon in adolescents with 2‐ to 5‐yr diabetes duration, despite more intensive management in recent years. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4632567 Tue, 01 Mar 2011 00:00:00 +0100 4632567 KCNJ11 activating mutations cause both transient and permanent neonatal diabetes mellitus in Cypriot patients http://www.medworm.com/index.php?rid=4513674&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00743.x Ioannou YS, Ellard S, Hattersley A, Skordis N. KCNJ11 activating mutations cause both transient and permanent neonatal diabetes mellitus in Cypriot patients.Heterozygous mutations of the KCNJ11 gene encoding the Kir6.2 subunit of the ATP‐sensitive potassium channel (KATP channel) of the pancreatic β‐cell cause diabetes in about 30–60% of all permanent neonatal diabetes mellitus cases diagnosed before 6 months of age. The KATP channel plays an essential role in the regulation of the electrical status of the membrane through which the secretion of insulin is activated. Transient neonatal diabetes mellitus due to KCNJ11 mutations is less frequent than abnormalities affecting the imprinted region of chromosome 6q24. We studied the genetic basis of two Cypriot patients who developed diab... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4513674 Thu, 24 Feb 2011 16:49:42 +0100 4513674 Insulin antibodies – are they still with us? Do they matter? http://www.medworm.com/index.php?rid=4513673&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00767.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4513673 Thu, 24 Feb 2011 16:49:37 +0100 4513673 Erratum http://www.medworm.com/index.php?rid=4401202&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00756.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4401202 Thu, 27 Jan 2011 15:48:13 +0100 4401202 List of Reviewers 2010 http://www.medworm.com/index.php?rid=4401201&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2011.00755.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4401201 Thu, 27 Jan 2011 15:48:12 +0100 4401201 Severe hypoglycemia in youth with T1DM: going, going … but not yet gone http://www.medworm.com/index.php?rid=4401200&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00754.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4401200 Thu, 27 Jan 2011 15:48:08 +0100 4401200 Longitudinal study of parechovirus infection in infancy and risk of repeated positivity for multiple islet autoantibodies: the MIDIA study http://www.medworm.com/index.php?rid=4339331&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00658.x The objective of this study was to investigate a possible association between human parechovirus infections in early infancy, diagnosed in fecal samples, and the development of islet autoimmunity. In the ‘Environmental Triggers of Type 1 Diabetes: The MIDIA study’, newborns with the highest genetic risk for type 1 diabetes were identified and followed with regular fecal sampling and questionnaires. A nested case–control study, including 27 children who developed islet autoimmunity (repeatedly positive for two or three autoantibodies) and 53 children matched for age and community of residence was used. Monthly stool samples from these children were analyzed for human parechovirus using a semi‐quantitative real‐time polymerase chain reaction. There was no significant difference in ... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4339331 Wed, 12 Jan 2011 00:00:00 +0100 4339331 Familial mild hyperglycemia associated with a novel ABCC8‐V84I mutation within three generations http://www.medworm.com/index.php?rid=4332689&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00719.x We present a unique case of a 19‐year‐old man with a positive family history of persistent mild hyperglycemia and a novel V84I mutation in ABCC8. The proband was initially detected to have fasting hyperglycemia (ranging 6.1–6.4 mmol/L) at the age of 12 years. Increased fasting blood glucose was also subsequently detected in five additional family members (in his twin brother, sister, mother, maternal aunt, and grandfather). The grandfather has been known to have mild diabetes since 30 years and has never been treated. After having excluded a causative mutation in five maturity‐onset diabetes of the young genes (MODY1–4 and 6), we identified a novel ABCC8 V84I mutation, which segregated with autosomal dominant transmission of mild hyperglycemia within three generations. This mutat... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4332689 Sun, 09 Jan 2011 00:00:00 +0100 4332689 Independent relationships of obesity and insulin resistance with serum proinsulin level in prepubertal children with normal glucose tolerance http://www.medworm.com/index.php?rid=4332688&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00696.x Conclusions: Obesity itself or obesity‐related IR may independently impose β‐cell overload on prepubertal children with NGT, leading to hyperproinsulinemia without causing failure to convert proinsulin to insulin when some degree of IR and metabolic derangement appears. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4332688 Sun, 09 Jan 2011 00:00:00 +0100 4332688 A laboratory standpoint on the role of hemoglobin A1c for the diagnosis of diabetes in childhood: more doubts than certainties? http://www.medworm.com/index.php?rid=4231109&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00684.x Lippi G, Targher G. A laboratory standpoint on the role of hemoglobin A1c for the diagnosis of diabetes in childhood: more doubts than certainties?The American Diabetes Association has recently included the measurement of hemoglobin A1c (A1c) among the criteria for diagnosing diabetes, so that this diagnostic strategy might also be extended in childhood and adolescence. Although the possibility of using A1c testing for screening and even diagnosing diabetes is highly appealing, A1c testing cannot be considered as yet the ‘panacea’ for a variety of reasons that include the suboptimal correlation with the mean blood glucose, the risk of misdiagnosis in children or adolescents with impaired renal function, iron‐deficiency anemia and increased red blood cell turnover, the interference fr... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4231109 Sun, 05 Dec 2010 00:00:00 +0100 4231109 The risk factors of ketoacidosis in children with newly diagnosed type 1 diabetes mellitus http://www.medworm.com/index.php?rid=4231108&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00689.x Conclusions: The incidence of DKA among newly diagnosed patients with T1DM remains unacceptably high and indicates greater necessity of medical alertness for this diagnosis, especially in the youngest children. Children under 2 yr of age remain the most prone to DKA, which may be related to delay in diagnosis and more aggressive β‐cell destruction. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4231108 Sun, 05 Dec 2010 00:00:00 +0100 4231108 Relationship of maternal weight status and weight gain rate during pregnancy to the development of advanced beta cell autoimmunity in the offspring: a prospective birth cohort study http://www.medworm.com/index.php?rid=4231107&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00703.x This study set out to examine how maternal initial body mass index (BMI) and weight gain during pregnancy associate with advanced beta cell autoimmunity in the offspring.Subjects: A population‐based birth cohort of 4093 children with increased human leukocyte antigen (HLA)‐conferred susceptibility to type 1 diabetes (T1D) and their mothers were recruited between 1997 and 2002 in two university hospital regions in Finland.Methods: The children were monitored for T1D‐associated autoantibodies at 3‐ to 12‐month intervals. Advanced beta cell autoimmunity was defined as repeated positivity for islet cell antibodies and at least one of the other three autoantibodies (antibodies to insulin, glutamate decarboxylase and islet antigen 2). Mothers were asked to record the results of the wei... Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4231107 Sun, 05 Dec 2010 00:00:00 +0100 4231107 Measurement site of visceral adipose tissue and prediction of metabolic syndrome in youth http://www.medworm.com/index.php?rid=4231106&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00705.x Conclusion: In AA and AW youth, the measurement site for VAT has impact on the estimation of total VAT and the magnitude of the association with obesity‐related health risks. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4231106 Sun, 05 Dec 2010 00:00:00 +0100 4231106 C‐peptide and long‐term complications of diabetes http://www.medworm.com/index.php?rid=4231105&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00729.x Luppi P, Cifarelli V, Wahren J. C‐peptide and long‐term complications of diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4231105 Sun, 05 Dec 2010 00:00:00 +0100 4231105 Report of the 36th ISPAD meeting, Buenos Aires, Argentina, 27–30 October 2010 http://www.medworm.com/index.php?rid=4215419&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00746.x Benitez‐Aguirre P, Maahs DM. Report of the 36th ISPAD meeting, Buenos Aires, Argentina, 27–30 October 2010. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4215419 Wed, 01 Dec 2010 00:00:00 +0100 4215419 Type 1 diabetes: a genetic Pandora's box? http://www.medworm.com/index.php?rid=4215418&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00742.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4215418 Wed, 01 Dec 2010 00:00:00 +0100 4215418 Detecting and treating hyperlipidemia in children with type 1 diabetes mellitus: are standard guidelines applicable to this special population?* http://www.medworm.com/index.php?rid=4135871&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00709.x Glaser NS, Geller DH, Haqq A, Gitelman S, Malloy M. Detecting and treating hyperlipidemia in children with type 1 diabetes mellitus: are standard guidelines applicable to this special population? (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4135871 Mon, 01 Nov 2010 00:00:00 +0100 4135871 The Environmental Determinants of Diabetes in the Young (TEDDY) Study: predictors of early study withdrawal among participants with no family history of type 1 diabetes http://www.medworm.com/index.php?rid=4110518&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00686.x Johnson SB, Lee H‐S, Baxter J, Lernmark B, Roth R, Simell T for the TEDDY Study Group. The Environmental Determinants of Diabetes in the Young (TEDDY) Study: predictors of early study withdrawal among participants with no family history of type 1 diabetes. (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4110518 Fri, 29 Oct 2010 17:51:24 +0100 4110518 Erratum http://www.medworm.com/index.php?rid=4101652&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00726.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4101652 Tue, 26 Oct 2010 00:59:13 +0100 4101652 Getting the most out of hemoglobin A1C testing http://www.medworm.com/index.php?rid=4101651&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00730.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4101651 Tue, 26 Oct 2010 00:59:08 +0100 4101651 Author Index http://www.medworm.com/index.php?rid=4019557&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00717.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4019557 Thu, 30 Sep 2010 23:00:00 +0100 4019557 Poster Sessions http://www.medworm.com/index.php?rid=4019556&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00716.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4019556 Thu, 30 Sep 2010 23:00:00 +0100 4019556 Oral Sessions http://www.medworm.com/index.php?rid=4019555&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00715.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4019555 Thu, 30 Sep 2010 23:00:00 +0100 4019555 Invited Speakers http://www.medworm.com/index.php?rid=4019554&cid=s_33007_15_f&fid=33007&url=http%3A%2F%2Fdx.doi.org%2F10.1111%252Fj.1399-5448.2010.00714.x (Source: Pediatric Diabetes) Pediatric Diabetes journals http://www.medworm.com/rss/comments.php?id=4019554 Thu, 30 Sep 2010 23:00:00 +0100 4019554