MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Pharmacoepidemiology and Drug Safety' source. Wed, 08 Feb 2012 14:04:27 +0100 http://www.medworm.com/index.php?rid=5667367&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.3194 ConclusionDifferences between PSR and PPR in estimating the prevalence of MSD drug use varied by the type of drug and the elapsed time from the index date. The patient‐assisted interview method used in this study showed better agreement with PPR compared with standard interviews, especially for long time windows and patients older than 65 years. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5667367 Tue, 07 Feb 2012 05:00:00 +0100 5667367 http://www.medworm.com/index.php?rid=5648126&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.3208 ConclusionsA potential purchaser of statins is likely to encounter websites from a wide geographical base and of generally poor quality. This has potentially serious implications for the safety of purchasers who may not be aware of the problems associated with ordering medicines online or the actual medication, which they receive. Direct to consumer advertising websites need tighter controls. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5648126 Thu, 02 Feb 2012 05:00:00 +0100 5648126 http://www.medworm.com/index.php?rid=5648127&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.3195 ConclusionClopidogrel and PPI coprescription with low‐dose ASA increased markedly between 2000–2001 and 2006–2007; however, many patients on low‐dose ASA did not receive the recommended coprescriptions at the end of the study period. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5648127 Wed, 01 Feb 2012 05:00:00 +0100 5648127 http://www.medworm.com/index.php?rid=5648128&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.3192 (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5648128 Tue, 31 Jan 2012 05:00:00 +0100 5648128 http://www.medworm.com/index.php?rid=5648131&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.3211 (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5648131 Mon, 30 Jan 2012 05:00:00 +0100 5648131 http://www.medworm.com/index.php?rid=5648130&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.3217 ConclusionsRecommended suspension of RV1 use led to a substantial decrease in use and extensive switching to RV5. The announcement that RV5 was similarly contaminated, but without a corresponding recommendation to suspend use, had little effect on use. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5648130 Mon, 30 Jan 2012 05:00:00 +0100 5648130 http://www.medworm.com/index.php?rid=5648129&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2349 ConclusionsExplicitly defining DPMs as RORs with applied shrinkage provides a convenient method for understanding their relative signal detection performance and insight into the relative contributions to DPM shrinkage. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5648129 Mon, 30 Jan 2012 05:00:00 +0100 5648129 http://www.medworm.com/index.php?rid=5628827&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.3196 ConclusionsThe indications for antimicrobial prescribing varied markedly between countries. We identified uroprophylaxis as a possible target for quality improvement. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628827 Tue, 24 Jan 2012 05:00:00 +0100 5628827 http://www.medworm.com/index.php?rid=5628826&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.3205 ConclusionsAlthough a training set still needs to be created manually, text mining can help reduce the amount of manual work needed to incorporate narrative data in an epidemiological study and will make the data extraction more reproducible. An advantage of machine learning is that it is able to pick up specific language use, such as abbreviations and synonyms used by physicians. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628826 Tue, 24 Jan 2012 05:00:00 +0100 5628826 http://www.medworm.com/index.php?rid=5597953&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2306 ABSTRACTWe review the concept of time‐dependent confounding by using the example in paper “Comparative effectiveness of individual angiotensin receptor blockers on risk of mortality in patients with chronic heart failure” by Desai et al. and illustrate how to adjust for it by using inverse probability of treatment weighting through a simulated example. We discuss a few subtle issues that arise in specification of the model for treatment required to fit marginal structural models (MSMs) and in specification of the structural model for the outcome. We discuss the differences between the effects estimated in MSMs and intention‐to‐treat effects estimated in randomized trials, followed by an outline of some limitations of MSMs. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Ph... Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5597953 Mon, 16 Jan 2012 05:00:00 +0100 5597953 http://www.medworm.com/index.php?rid=5597952&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2262 ConclusionsClinical and demographic characteristics influence choice and duration of initial oral hypoglycemic treatment as well as regimen changes. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5597952 Mon, 16 Jan 2012 05:00:00 +0100 5597952 http://www.medworm.com/index.php?rid=5582065&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2308 ConclusionsThe co‐prescription of CYP3A4‐metabolised statins and CYP3A4 inhibitors is common in UK primary care. This co‐prescription suggests the limited appreciation of potential interactions and Medicines and Healthcare products Regulatory Agency safety advice, with the potential to increase likelihood for side effects amongst patients. Strategies to reduce drug interactions with potential adverse effects should be targeted at prescribers and pharmacists. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5582065 Thu, 12 Jan 2012 05:00:00 +0100 5582065 http://www.medworm.com/index.php?rid=5582064&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2273 (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5582064 Thu, 12 Jan 2012 05:00:00 +0100 5582064 http://www.medworm.com/index.php?rid=5582066&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2275 ConclusionPopulation exposure to systemic piroxicam remained unaffected by a previous health safety warning but declined sharply after the introduction of prior authorisation. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5582066 Tue, 10 Jan 2012 05:00:00 +0100 5582066 http://www.medworm.com/index.php?rid=5582068&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2274 ConclusionsThe presence or absence of symptoms does not help guide whether valvular regurgitation is present or absent in individuals exposed to pergolide. Therefore, echocardiography is needed to confirm or refute pergolide‐associated VHD. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5582068 Mon, 09 Jan 2012 05:00:00 +0100 5582068 http://www.medworm.com/index.php?rid=5582067&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2346 ConclusionsAge and gender trends are consistent with international literature. However, Ireland has higher overall prescribing rates relative to some European countries. This suggests that a quality improvement in prescribing intervention is warranted. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5582067 Mon, 09 Jan 2012 05:00:00 +0100 5582067 http://www.medworm.com/index.php?rid=5560366&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2351 ConclusionPEM is inferior to PC for accurate monitoring of drug nonadherence. The inaccuracy is due to erroneous prescription information. PEM could be a powerful tool for electronic monitoring of drug nonadherence if prescription information was recorded uniformly and correctly. To increase the accuracy, we recommend informal free‐text dosing instruction to be translated into a formal one by use of appropriate software such as library of phrases. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5560366 Wed, 04 Jan 2012 05:00:00 +0100 5560366 http://www.medworm.com/index.php?rid=5560365&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2339 ConclusionConcordance with guideline recommendations increased for celecoxib and decreased for tNSAIDs after rofecoxib withdrawal; GPA co‐prescription with tNSAIDs remained suboptimal. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5560365 Wed, 04 Jan 2012 05:00:00 +0100 5560365 http://www.medworm.com/index.php?rid=5667368&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.3230 No abstract is available for this article. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5667368 Sun, 01 Jan 2012 05:00:00 +0100 5667368 http://www.medworm.com/index.php?rid=5667366&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.3197 ConclusionActive surveillance using healthcare data‐based networks for signal detection is feasible, although the leverage to do so may be low for infrequently used drugs and for rare outcomes. Extending database network size to include data from heterogeneous populations and increasing follow‐up time are warranted to maximize leverage of these surveillance systems. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5667366 Sun, 01 Jan 2012 05:00:00 +0100 5667366 http://www.medworm.com/index.php?rid=5648132&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.3230 No abstract is available for this article. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5648132 Sun, 01 Jan 2012 05:00:00 +0100 5648132 http://www.medworm.com/index.php?rid=5648125&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.3193 DiscussionPhase 2 data added valuable information on smoking and BMI. However, phase 1 results did not change dramatically after accounting for phase 2 information, which is reassuring for the validity of database studies. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5648125 Sun, 01 Jan 2012 05:00:00 +0100 5648125 http://www.medworm.com/index.php?rid=5628864&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2323 ABSTRACTIn 2009, the Department of Health and Human Services created the new Post‐Licensure Rapid Immunization Safety Monitoring (PRISM) program, which used data from national health insurance plans and immunization registries to monitor the safety of the H1N1 influenza vaccine. PRISM has now been integrated into the FDA's Mini‐Sentinel pilot program. It strengthens the federal vaccine safety enterprise in two important ways. First, PRISM monitors the largest US general population cohort designated for active surveillance of vaccine safety. Second, PRISM links data from health plans with data from state and city immunization registries, which were a crucial source of exposure data in the H1N1 vaccine evaluation. The Mini‐Sentinel data that support PRISM are updated quarterly, and PRI... Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628864 Sun, 01 Jan 2012 05:00:00 +0100 5628864 http://www.medworm.com/index.php?rid=5628862&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2337 ConclusionsThe proposed protocol describes a design for surveillance to evaluate the safety of a newly marketed agent as postmarket experience accrues. It uses data from multiple partner organizations without requiring sharing of patient‐level data and compares alternative approaches to controlling for confounding. It is hoped that this initial active surveillance project of the Mini‐Sentinel will provide insights that inform future population‐based surveillance of medical product safety. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628862 Sun, 01 Jan 2012 05:00:00 +0100 5628862 http://www.medworm.com/index.php?rid=5628861&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2314 ConclusionsWe have established a process to validate AMI within Mini‐Sentinel, which may be used for other health outcomes. Challenges include the following: (i) ensuring that only minimum necessary data are transmitted by Data Partners for centralized chart review, (ii) establishing procedures to maintain data privacy while still allowing for timely access to medical charts, and (iii) securing access to charts for public health uses that do not require approval from an institutional review board while maintaining patient privacy. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628861 Sun, 01 Jan 2012 05:00:00 +0100 5628861 http://www.medworm.com/index.php?rid=5628860&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2309 ConclusionsValidation data, with regard to the ICD‐9‐CM or the Current Procedural Terminology code algorithms for revision THA in the Medicare population, exist. More validation studies are needed to confirm these findings and examine other large databases. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628860 Sun, 01 Jan 2012 05:00:00 +0100 5628860 http://www.medworm.com/index.php?rid=5628859&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2326 ConclusionsResearch needs to be conducted on designing validation studies to test ARF algorithms and estimating their predictive power, sensitivity, and specificity. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628859 Sun, 01 Jan 2012 05:00:00 +0100 5628859 http://www.medworm.com/index.php?rid=5628858&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2338 ConclusionsResearch needs to be conducted on designing validation studies to test pulmonary fibrosis and interstitial lung disease algorithms and estimating their predictive power, sensitivity, and specificity. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628858 Sun, 01 Jan 2012 05:00:00 +0100 5628858 http://www.medworm.com/index.php?rid=5628857&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2333 ConclusionsThe ability of coding algorithms to identify hypersensitivity reactions varied, with decreasing performance occurring with expanded outcome definitions. This examination of hypersensitivity‐reaction coding algorithms provides an example of surveillance bias resulting from outcome definitions that include mild cases. Data mining may provide tools for algorithm development for hypersensitivity and other health outcomes. Research needs to be conducted on designing validation studies to test hypersensitivity‐reaction algorithms and estimating their predictive power, sensitivity, and specificity. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628857 Sun, 01 Jan 2012 05:00:00 +0100 5628857 http://www.medworm.com/index.php?rid=5628856&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2327 ConclusionsResearch needs to be conducted on designing validation studies to test anaphylaxis algorithms and estimating their predictive power, sensitivity, and specificity. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628856 Sun, 01 Jan 2012 05:00:00 +0100 5628856 http://www.medworm.com/index.php?rid=5628854&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2331 ConclusionsUpdated research needs to be conducted on designing validation studies that test algorithms for erythema multiforme and related conditions and that take into account recent changes in the diagnostic coding of these diseases. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628854 Sun, 01 Jan 2012 05:00:00 +0100 5628854 http://www.medworm.com/index.php?rid=5628853&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2325 ConclusionsThere is no information to assess the validity of algorithms to identify transfusion‐related ABO incompatibility reactions. Further information on the validity of algorithms to identify transfusions would also be useful. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628853 Sun, 01 Jan 2012 05:00:00 +0100 5628853 http://www.medworm.com/index.php?rid=5628852&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2322 ConclusionsThere is no information to assess the validity of algorithms to identify transfusion‐related sepsis or septicemia. Codes to identify sepsis performed well in most studies. Algorithms to identify transfusions need further research that includes a broader range of transfusion types. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628852 Sun, 01 Jan 2012 05:00:00 +0100 5628852 http://www.medworm.com/index.php?rid=5628851&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2332 ConclusionsThere is little evidence to support the validity of algorithms to identify infections related to blood products, tissue grafts, or organ transplants in administrative data or algorithms to identify the exposures. Although it may be possible to validate algorithms to identify the exposures and infectious outcomes, the use of administrative data to identify infections transmitted by these exposures may be challenging. Codes indicating infections acquired through medical care may be useful. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628851 Sun, 01 Jan 2012 05:00:00 +0100 5628851 http://www.medworm.com/index.php?rid=5628850&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2315 ConclusionThe International Classification of Disease, Ninth Revision diagnostic, clinical procedure, and complication codes for lymphoma can identify incident hematologic malignancies and solid tumors with high specificity but with relatively low to moderate sensitivity and PPVs. When diagnostic and procedure codes were required on the same visit or multiple codes between visits, then PPV was increased. Relying on a single registry to confirm true positive cases is also not sufficient. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628850 Sun, 01 Jan 2012 05:00:00 +0100 5628850 http://www.medworm.com/index.php?rid=5628849&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2334 ConclusionsValidation studies find that the principal ICD‐9‐CM diagnosis code of 577.0 had the best positive predictive value and specificity. Current studies do not support the use of the ICD‐9‐CM codes 577.1 and 577.2. Databases enhanced with laboratory values at point of care would invariably increase the specificity of existing algorithms. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628849 Sun, 01 Jan 2012 05:00:00 +0100 5628849 http://www.medworm.com/index.php?rid=5628848&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2329 ConclusionsAlgorithm performance was highly variable, so it is difficult to draw any strong conclusions. However, the PPVs were generally best in studies where epilepsy diagnoses were required. Using procedure codes for electroencephalograms or prescription claims for drugs possibly used for epilepsy or convulsions in the absence of a diagnostic code is not recommended. Many newer AEDs require no drug level monitoring, so requiring an AED level monitoring procedure in algorithms to identify epilepsy is not recommended. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628848 Sun, 01 Jan 2012 05:00:00 +0100 5628848 http://www.medworm.com/index.php?rid=5628847&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2335 ConclusionsInsufficient data exist to support specific recommendations regarding a preferred algorithm, and caution should be exercised in interpreting clinical and pharmacological epidemiological surveillance and research that rely on these codes as measures of suicide‐related outcomes. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628847 Sun, 01 Jan 2012 05:00:00 +0100 5628847 http://www.medworm.com/index.php?rid=5628845&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2310 (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628845 Sun, 01 Jan 2012 05:00:00 +0100 5628845 http://www.medworm.com/index.php?rid=5628844&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2341 ConclusionsThe use of ICD‐9 415, 451, and 453 are appropriate for the identification of VTE in claims databases. The codes performed best when codes were evaluated in patients at higher risk of VTE. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628844 Sun, 01 Jan 2012 05:00:00 +0100 5628844 http://www.medworm.com/index.php?rid=5628843&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2340 ConclusionsThe use of ICD‐9 codes 427.x, alone or in combination with code 798.x, in the principal position is appropriate for the identification of ventricular arrhythmias in administrative and claims databases. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628843 Sun, 01 Jan 2012 05:00:00 +0100 5628843 http://www.medworm.com/index.php?rid=5628842&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2317 ConclusionsThe ICD‐9 code 427.31 performed relatively well, but conclusions about algorithm validity are hindered by few recent data, use of nonrepresentative populations, and a disproportionate focus on inpatient data. An optimal contemporary algorithm would likely draw on inpatient and outpatient codes and electronic ECG data. Additional research is needed in representative, contemporary populations regarding algorithms that identify incident AF and incorporate electronic ECG data. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628842 Sun, 01 Jan 2012 05:00:00 +0100 5628842 http://www.medworm.com/index.php?rid=5628841&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2313 ConclusionsThe algorithms and definitions used to identify HF using administrative and claims data perform well, particularly when using a primary hospital discharge diagnosis. Attention should be paid to whether patients who are managed on an outpatient basis are included in the study sample. Including outpatient codes in the described algorithms would increase the sensitivity for identifying new cases of HF. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628841 Sun, 01 Jan 2012 05:00:00 +0100 5628841 http://www.medworm.com/index.php?rid=5628840&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2312 ConclusionsThe algorithms and definitions to identify CVAs and TIAs using administrative and claims data differ greatly in the published literature. The choice of the algorithm employed should be determined by the stroke subtype of interest. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628840 Sun, 01 Jan 2012 05:00:00 +0100 5628840 http://www.medworm.com/index.php?rid=5628839&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2318 ConclusionUsers of these reviews need to consider the generalizability of findings to their study populations. For some outcomes with poorly performing codes, it may always be necessary to validate cases. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628839 Sun, 01 Jan 2012 05:00:00 +0100 5628839 http://www.medworm.com/index.php?rid=5628838&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2321 ConclusionsThe Mini‐Sentinel systematic reviews of algorithms to identify health outcomes in administrative and claims data are expected to be relatively complete, despite some limitations. Algorithm validation studies are inconsistently indexed in PubMed, creating challenges in conducting systematic reviews of these studies. Google Scholar searches, which can perform text word searches of electronically available articles, are suggested as a strategy to identify studies that are not captured through searches of standard citation databases. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628838 Sun, 01 Jan 2012 05:00:00 +0100 5628838 http://www.medworm.com/index.php?rid=5628837&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2320 ABSTRACTPurposeThis manuscript describes the current statistical methodology available for active postmarket surveillance of pre‐specified safety outcomes using a prospective incident user concurrent control cohort design with existing electronic healthcare data.MethodsMotivation of the active postmarket surveillance setting is provided using the Food and Drug Administration's Mini‐Sentinel Pilot as an example. Four sequential monitoring statistical methods are presented including the Lan–Demets error spending approach, a matched likelihood ratio test statistic approach with the binomial MaxSPRT as a special case, the conditional sequential sampling procedure with stratification, and a generalized estimating equation regression approach using permutation. Information on the assumptio... Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628837 Sun, 01 Jan 2012 05:00:00 +0100 5628837 http://www.medworm.com/index.php?rid=5628836&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2324 ConclusionsAll designs control the overall Type 1 error rate across all tests performed, but each yields different tradeoffs between the probability and timing of true and false positive signals. Designs tailored to monitor efficacy outcomes in clinical trials have been well studied, but less consideration has been given to optimizing design choices for observational safety settings, where the hypotheses, population, prevalence and severity of the outcomes, implications of signaling, and costs of false positive and negative findings are very different. Analytic challenges include confounding, missing and partially accrued data, high misclassification rates for outcomes presumptively defined using diagnostic codes, and unpredictable changes in dynamically accessed data over time (e.g., diff... Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628836 Sun, 01 Jan 2012 05:00:00 +0100 5628836 http://www.medworm.com/index.php?rid=5628835&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2330 ConclusionThe case‐only analyses of intermittent users complement the cohort analyses of prolonged users because their different biases compensate for one another. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628835 Sun, 01 Jan 2012 05:00:00 +0100 5628835 http://www.medworm.com/index.php?rid=5628834&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2328 ABSTRACTDistributed medical product safety monitoring systems such as the Sentinel System, to be developed as a part of Food and Drug Administration's Sentinel Initiative, will require automation of large parts of the safety evaluation process to achieve the necessary speed and scale at reasonable cost without sacrificing validity. Although certain functions will require investigator intervention, confounding control is one area that can largely be automated. The high‐dimensional propensity score (hd‐PS) algorithm is one option for automated confounding control in longitudinal healthcare databases. In this article, we discuss the use of hd‐PS for automating confounding control in sequential database cohort studies, as applied to safety monitoring systems. In particular, we discuss th... Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628834 Sun, 01 Jan 2012 05:00:00 +0100 5628834 http://www.medworm.com/index.php?rid=5628833&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2316 ABSTRACTActive medical product monitoring systems, such as the Sentinel System, will utilize electronic healthcare data captured during routine health care. Safety signals that arise from these data may be spurious because of chance or bias, particularly confounding bias, given the observational nature of the data. Applying appropriate monitoring designs can filter out many false‐positive and false‐negative associations from the outset. Designs can be classified by whether they produce estimates based on between‐person or within‐person comparisons. In deciding which approach is more suitable for a given monitoring scenario, stakeholders must consider the characteristics of the monitored product, characteristics of the health outcome of interest (HOI), and characteristics of the pot... Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628833 Sun, 01 Jan 2012 05:00:00 +0100 5628833 http://www.medworm.com/index.php?rid=5628832&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2336 ConclusionThis work demonstrates the feasibility of building a large, multiorganizational distributed data system in which organizations retain possession of their data that are used in an active surveillance system. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628832 Sun, 01 Jan 2012 05:00:00 +0100 5628832 http://www.medworm.com/index.php?rid=5628831&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2319 This article summarizes how the initial pilot phase of the FDA's Sentinel Initiative, Mini‐Sentinel, is being conducted in compliance with applicable federal and state laws. The article also sets forth the attributes of Mini‐Sentinel that enhance privacy and public trust, including the use of a distributed data system (where identifiable information remains at the data partners) and the adoption by participants of additional mandatory policies and procedures implementing fair information practices. The authors conclude by discussing the implications of this model for other types of secondary health data uses. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628831 Sun, 01 Jan 2012 05:00:00 +0100 5628831 http://www.medworm.com/index.php?rid=5628830&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2242 We describe the program's current organizational structure and its major principles and policies. The organization includes a coordinating center with program leadership provided by a principal investigator; a planning board and subcommittees; an operations center; and data, methods, and protocol cores. Ad hoc workgroups are created as needed. A privacy panel advises about protection of individual health information. Principles and policies are intended to ensure that Mini‐Sentinel conforms to the principles of fair information practices, protects the privacy of individual health information, maintains the security and integrity of data, assures the confidentiality of proprietary information, provides accurate and timely communications, prevents or manages conflicts of interest, and pres... Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628830 Sun, 01 Jan 2012 05:00:00 +0100 5628830 http://www.medworm.com/index.php?rid=5628829&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2311 (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628829 Sun, 01 Jan 2012 05:00:00 +0100 5628829 http://www.medworm.com/index.php?rid=5628828&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2343 ABSTRACTThe Mini‐Sentinel is a pilot program that is developing methods, tools, resources, policies, and procedures to facilitate the use of routinely collected electronic healthcare data to perform active surveillance of the safety of marketed medical products, including drugs, biologics, and medical devices. The U.S. Food and Drug Administration (FDA) initiated the program in 2009 as part of its Sentinel Initiative, in response to a Congressional mandate in the FDA Amendments Act of 2007.After two years, Mini‐Sentinel includes 31 academic and private organizations. It has developed policies, procedures, and technical specifications for developing and operating a secure distributed data system comprised of separate data sets that conform to a common data model covering enrollment, dem... Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628828 Sun, 01 Jan 2012 05:00:00 +0100 5628828 http://www.medworm.com/index.php?rid=5628825&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2350 ConclusionsOverall, PPI therapy among corticosteroid users was uncommon, even among those with risk factors for gastrointestinal toxicity. PPI use was significantly more common among patients who had recently been hospitalized, had a greater burden of comorbid illness, or were receiving high daily doses of corticosteroids. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5628825 Sun, 01 Jan 2012 05:00:00 +0100 5628825 http://www.medworm.com/index.php?rid=5620277&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2345 ConclusionsStarting insulin rather than adding another OGLD to double or triple oral therapy did not significantly increase the incidence of vascular events. Beginning insulin from one OGLD was uncommon. More incident macrovascular disease in this group may be caused by residual confounding. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5620277 Sun, 01 Jan 2012 05:00:00 +0100 5620277 http://www.medworm.com/index.php?rid=5597951&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2348 ConclusionsThere has been an enormous increase in ADHD medication consumption in Castilla y León in the last few years; increase rocketed when extended‐release methylphenidate was marketed. A rapid increase in the consumption is a warning on possible overdiagnosis and inappropriate prescription. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5597951 Sun, 01 Jan 2012 05:00:00 +0100 5597951 http://www.medworm.com/index.php?rid=5582063&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2344 ConclusionsIn women, the most important factors for being adherent were high age and high income. In men, a middle educational level predicted adherence. Previous marriage reduced the odds of being adherent in both women and men. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5582063 Sun, 01 Jan 2012 05:00:00 +0100 5582063 http://www.medworm.com/index.php?rid=5572295&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.3200 ConclusionCompliance with the contraceptive use according to a PPP for a teratogenic drug such as isotretinoin is 52%–64%, which is lower than anticipated. Reasons for the low compliance will need to be clarified before further measures can be taken. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5572295 Sun, 01 Jan 2012 05:00:00 +0100 5572295 http://www.medworm.com/index.php?rid=5560364&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2347 ConclusionsThe proposed approach explicitly accounts for accuracy in alerting, timeliness in alerting, and the trade‐offs between the costs of false negative and false positive alerting. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5560364 Sun, 01 Jan 2012 05:00:00 +0100 5560364 http://www.medworm.com/index.php?rid=5487026&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2307 ConclusionThe present study underlines the interest of a National Pharmacovigilance Database to follow each year the role of drugs in heat‐related ADRs. This survey should be associated with other pharmacoepidemiological methods, such as case–control or population‐based studies. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5487026 Thu, 08 Dec 2011 05:00:00 +0100 5487026 http://www.medworm.com/index.php?rid=5476734&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2222 (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5476734 Tue, 06 Dec 2011 05:00:00 +0100 5476734 http://www.medworm.com/index.php?rid=5476735&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2276 ConclusionsThere was good concordance between the reporting frequencies observed in the FDA AERS database and the published risk estimation of medications implicated in SJS/TEN. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5476735 Mon, 05 Dec 2011 05:00:00 +0100 5476735 http://www.medworm.com/index.php?rid=5505070&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2200 ConclusionsThe overall error rates in both phases of SDV demonstrate acceptable data accuracy in the MPS I Registry within the data fields that were assessed. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5505070 Thu, 01 Dec 2011 05:00:00 +0100 5505070 http://www.medworm.com/index.php?rid=5487025&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2256 ConclusionsOur empirical and simulation results indicated that using a cohort PS in subgroup analyses was a feasible approach, particularly in larger subgroups. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5487025 Thu, 01 Dec 2011 05:00:00 +0100 5487025 http://www.medworm.com/index.php?rid=5476733&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2266 ConclusionsThe epidemiological data in a US cohort with up to 12 years of follow‐up and a UK cohort with up to 15 years of follow‐up do not support a carcinogenic effect of gabapentin use. However, the confidence intervals for some analyses were wide, and an important effect cannot be confidently excluded. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5476733 Thu, 01 Dec 2011 05:00:00 +0100 5476733 http://www.medworm.com/index.php?rid=5457950&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2179 ConclusionAntibiotic use in early pregnancy was not a major risk factor for isolated orofacial clefts in our study. Some classes of antibiotics used in the critical period for development of CL/P and CP may increase the risk; however, other factors such as indications for use and chance may explain these findings. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5457950 Thu, 01 Dec 2011 05:00:00 +0100 5457950 http://www.medworm.com/index.php?rid=5441207&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2258 ConclusionsADT in elderly men with prostate cancer increased the incidence of fractures, and the effect appears to diminish with increasing time since the last dose of a GnRH agonist. Experiencing a fracture after the diagnosis of prostate cancer was associated with decreased survival. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5441207 Fri, 25 Nov 2011 06:46:53 +0100 5441207 http://www.medworm.com/index.php?rid=5441209&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2267 DiscussionThe use of dopamine agonists, especially pramipexole and cabergoline, is associated with an increased risk of heart failure. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5441209 Wed, 23 Nov 2011 05:00:00 +0100 5441209 http://www.medworm.com/index.php?rid=5441208&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2263 ConclusionThree years after the launch of the buprenorphine generic, the health professionals' and buprenorphine users' perception of generic can still change. Additionally, the long‐term impact of generic medications with abuse potential has not yet been studied. Thus, continued monitoring of buprenorphine is needed. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5441208 Wed, 23 Nov 2011 05:00:00 +0100 5441208 http://www.medworm.com/index.php?rid=5408413&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2250 ConclusionsMany patients that received an opioid for chronic pain were prescribed concomitant medications with the potential for safety‐related DDIs or interactions that would alter the effectiveness of the opioid. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5408413 Mon, 14 Nov 2011 05:00:00 +0100 5408413 http://www.medworm.com/index.php?rid=5387200&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2229 ABSTRACTThe use of healthcare databases in research provides advantages such as increased speed, lower costs and limitation of some biases. However, database research has its own challenges as studies must be performed within the limitations of resources, which often are the product of complex healthcare systems. The primary purpose of this document is to assist in the selection and use of data resources in pharmacoepidemiology, highlighting potential limitations and recommending tested procedures. This guidance is presented as a detailed text with a checklist for quick reference and covers six areas: selection of a database, use of multiple data resources, extraction and analysis of the study population, privacy and security, quality and validation procedures and documentation. Copyright ... Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5387200 Tue, 08 Nov 2011 05:00:00 +0100 5387200 http://www.medworm.com/index.php?rid=5387199&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2268 ConclusionsThis study showed few differences between men and women after stroke. Patients' use of secondary preventive drugs needs to be improved, and from a public health perspective, poor persistence is probably a greater problem than differences between the sexes. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5387199 Tue, 08 Nov 2011 05:00:00 +0100 5387199 http://www.medworm.com/index.php?rid=5387201&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2210 ConclusionThis study suggests an increased risk of PE with AP treatment, varying with type of AP and dependent on dose. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5387201 Fri, 04 Nov 2011 04:00:00 +0100 5387201 http://www.medworm.com/index.php?rid=5387203&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2270 ConclusionsWe propose a new, two‐stage approach in identifying outliers in longitudinal data and show that it can successfully identify outliers at both population and individual level. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5387203 Thu, 03 Nov 2011 04:00:00 +0100 5387203 http://www.medworm.com/index.php?rid=5387202&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2243 ConclusionDiagnostic data processed from electronic health records identified the rates of common health events experienced by young female patients routinely visiting their GP or GYN before HPV immunization. Such rates may prove useful in interpreting adverse events reported after the launch of new medical interventions. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5387202 Thu, 03 Nov 2011 04:00:00 +0100 5387202 http://www.medworm.com/index.php?rid=5422307&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2261 ConclusionIf utilized at the time, this disproportionality analysis would have identified signals earlier for lead fractures, oversensing, high impedance, and inappropriate shock. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5422307 Tue, 01 Nov 2011 04:00:00 +0100 5422307 http://www.medworm.com/index.php?rid=5408412&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2259 ConclusionGiven the risks associated with meperidine, determining that this intervention successfully reduced meperidine use is encouraging. This study highlights the potential for using population data such as the NSPMP to evaluate the effectiveness of population‐level interventions to improve medication use, including professional, organizational, financial, and regulatory initiatives. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5408412 Tue, 01 Nov 2011 04:00:00 +0100 5408412 http://www.medworm.com/index.php?rid=5400870&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2265 ConclusionsPsychiatric ADRs in the pediatric population have been reported for a wide range of reactions and drugs and display age and sex differences including a higher number of suicidal reactions in boys. An association was seen between serious reactions and off‐label drug use. Further studies are needed to elucidate safety aspects of unlicensed drugs and drugs used off‐label and whether there are differences in children's susceptibility to develop ADRs. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5400870 Tue, 01 Nov 2011 04:00:00 +0100 5400870 http://www.medworm.com/index.php?rid=5387198&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2269 ConclusionContinuous focus on safety aspects of AEDs and the importance of the implementation of pharmacovigilance contribute to further optimized therapy on a large scale and for the individual patient. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5387198 Tue, 01 Nov 2011 04:00:00 +0100 5387198 http://www.medworm.com/index.php?rid=5347724&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2260 ConclusionsExperimental studies were found to be the main source of meta‐analyses on drug safety. The role of meta‐analyses in pharmacovigilance is a matter of ongoing debate, and efforts are being made to develop guidelines on the use of meta‐analysis in drug safety assessments, to better combine evidence about harms. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5347724 Wed, 26 Oct 2011 13:00:53 +0100 5347724 http://www.medworm.com/index.php?rid=5347725&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2264 ConclusionsSupply‐side healthcare factors may contribute to the rise from 2001 to 2003 in ADHD medication prescriptions. This finding warrants attention because it implies that the relative capacity of the healthcare system may influence population prescription rates. We encourage further exploration of the contribution of the supply‐side of the healthcare market to secular changes in ADHD medication prescriptions. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5347725 Mon, 24 Oct 2011 04:00:00 +0100 5347725 http://www.medworm.com/index.php?rid=5336079&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2252 ConclusionProbabilistic record linkage methods were effective for records linkage in this sub‐Saharan African setting. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5336079 Tue, 18 Oct 2011 04:00:00 +0100 5336079 http://www.medworm.com/index.php?rid=5314723&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2247 ConclusionsConsequently, performance characteristics were best for leading terms with narrow MedDRA query searches irrespective of applying Multi‐item Gamma Poisson Shrinker or LR at a threshold value of 2.0. This research formed the basis for the configuration of ESS for signal detection at Novartis. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5314723 Wed, 12 Oct 2011 04:00:00 +0100 5314723 http://www.medworm.com/index.php?rid=5285897&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2227 ConclusionThis meta‐analysis supports an increased risk of ischemic stroke with the current use of rofecoxib and diclofenac. Additional studies are required to evaluate most individual NSAIDS, the effect of dose and duration, and the subtypes of stroke. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5285897 Mon, 03 Oct 2011 04:00:00 +0100 5285897 http://www.medworm.com/index.php?rid=5336078&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2257 ConclusionsA 90‐day death proxy is a robust substitute to identify death in a chronic population when fact of death is not available. The proxy is likely to be valid across a range of chronic diseases as it relies on the presence of ‘regular’ dispensing records for individual patients. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5336078 Sat, 01 Oct 2011 04:00:00 +0100 5336078 http://www.medworm.com/index.php?rid=5314722&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2248 ConclusionsWe showed that a minimal set of prescribing quality indicators for type 2 diabetes mellitus care should not just focus on the management of different clinical risk factors but also reflect different steps of treatment intensification. The results of our study are relevant for stakeholders when selecting quality indicators to assess the quality of prescribing in diabetic patients. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5314722 Sat, 01 Oct 2011 04:00:00 +0100 5314722 http://www.medworm.com/index.php?rid=5285896&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2237 ConclusionThis study suggested that the RR was the most accurate of the DMIs for detecting signals in the claims database. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5285896 Sat, 01 Oct 2011 04:00:00 +0100 5285896 http://www.medworm.com/index.php?rid=5260996&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2220 (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5260996 Thu, 29 Sep 2011 05:45:38 +0100 5260996 http://www.medworm.com/index.php?rid=5260995&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2239 (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5260995 Thu, 29 Sep 2011 05:45:37 +0100 5260995 http://www.medworm.com/index.php?rid=5260994&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2238 (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5260994 Thu, 29 Sep 2011 05:45:36 +0100 5260994 http://www.medworm.com/index.php?rid=5260987&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2225 ConclusionsThe increased use of oral anticancer agents is mainly due to the frequent prescription of capecitabine. The increased costs are caused by the registration of a variety of TKIs, in particular imatinib. The costs of new agents with an orphan drug status are very high as compared with those of capecitabine, a newer agent for which there are alternative treatment options. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5260987 Thu, 29 Sep 2011 05:44:15 +0100 5260987 http://www.medworm.com/index.php?rid=5260990&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2240 ConclusionsPsychiatrists show a favorable attitude to involve patients in a process of reciprocal communication, where patients' preferences, values, and expectations are considered, but they are more cautious in their attitude to sharing decisions with patients. There is scope for the different kinds of research in this area: studying sex‐based differences in psychiatrists' attitudes to concordance and also exploring the gap in mental health care between patients' and professionals' views of shared decision making. Only in this way can the real partnership for shared decision making be fully understood. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5260990 Wed, 28 Sep 2011 04:00:00 +0100 5260990 http://www.medworm.com/index.php?rid=5260989&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2245 ConclusionHealthcare professionals who provide immunizations need additional information on their role in vaccine safety and AE reporting. Strengthening both passive and active reporting systems can enhance surveillance efforts during real‐time events, such as mass immunization during a pandemic and other large‐scale emergency countermeasure distribution programs. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5260989 Wed, 28 Sep 2011 04:00:00 +0100 5260989 http://www.medworm.com/index.php?rid=5260988&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2255 ConclusionIn this nationwide study, long‐term use of statins is associated with the reduction in CHD mortality. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5260988 Wed, 28 Sep 2011 04:00:00 +0100 5260988 http://www.medworm.com/index.php?rid=5260992&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2241 ConclusionsIn nearly one of five encounters, a direct pharmacist–patient interaction about self‐medication revealed relevant DRPs. Having access to patient files including data on prescription and OTC drugs may increase patient safety. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5260992 Tue, 27 Sep 2011 04:00:00 +0100 5260992 http://www.medworm.com/index.php?rid=5260991&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2253 ConclusionsTemporary interruption of ACE‐I and ARA may be considered at the time of IVIg infusion. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5260991 Tue, 27 Sep 2011 04:00:00 +0100 5260991 http://www.medworm.com/index.php?rid=5260993&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2254 ConclusionThe Healthy Pregnant data set was not representative of the general pregnant population in the northern part of the Netherlands. Specifically, the exposure to (chronic) drugs was underestimated, possibly a result of second‐line care on the basis of medical indication. Thus, continuous investigation of options for improvement of the Healthy Pregnant database is required. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5260993 Mon, 26 Sep 2011 04:00:00 +0100 5260993 http://www.medworm.com/index.php?rid=5250870&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2233 ConclusionsAn excess occurrence of comorbidities was found in the population with asthma. A majority of people with asthma had one additional chronic disease, and few had more than one. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5250870 Fri, 23 Sep 2011 04:00:00 +0100 5250870 http://www.medworm.com/index.php?rid=5238003&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2236 ConclusionsA third of children infected with human immunodeficiency virus fail to adhere to their treatment because of poor drug taste. Physicians are aware of that, but this does not prevent them from selecting the least palatable drugs as first‐line therapy. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5238003 Wed, 21 Sep 2011 04:00:00 +0100 5238003 http://www.medworm.com/index.php?rid=5225979&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2196 ConclusionThis comprehensive research will improve understanding of the safety of these treatments. The methods described may be useful to others planning similar evaluations. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5225979 Thu, 15 Sep 2011 04:00:00 +0100 5225979 http://www.medworm.com/index.php?rid=5225978&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2224 ConclusionUsing a comprehensive, computer‐assisted HMR in an ambulatory care setting we have identified a high proportion of pDDI of moderate or serious clinical relevance. These pDDI require an intervention from intensified monitoring to a change in medication. Further investigations should focus on clinical outcome of pDDI. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5225978 Thu, 15 Sep 2011 04:00:00 +0100 5225978 http://www.medworm.com/index.php?rid=5225977&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2246 ConclusionIn this community‐based study, palivizumab was associated with a reduction in severe RSV infections of a magnitude comparable to the lower clinical trial efficacy estimates. Protection appears to extend beyond the currently recommended monthly dosing schedule. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5225977 Thu, 15 Sep 2011 04:00:00 +0100 5225977 http://www.medworm.com/index.php?rid=5225984&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2232 ConclusionsThere are significant differences in the quality of drug prescribing in nursing homes compared with home nursing services. Explanations as to why these differences exist need to be further explored. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5225984 Tue, 13 Sep 2011 04:00:00 +0100 5225984 http://www.medworm.com/index.php?rid=5225983&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2231 (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5225983 Tue, 13 Sep 2011 04:00:00 +0100 5225983 http://www.medworm.com/index.php?rid=5225982&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2230 ConclusionsThe linear relationship between the TI and the increasing number of dispensed drugs per individual provides poor support for using decreasing TI as an estimator of non‐adherence. The low rate of cost‐related non‐adherence in Sweden might contribute to explaining the linear relationship. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5225982 Tue, 13 Sep 2011 04:00:00 +0100 5225982 http://www.medworm.com/index.php?rid=5225981&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2234 ConclusionsA “certainty‐response” (stronger association with higher level of certainty) was found within exposures in the window of etiological interest. Algorithms for exposure classification that incorporate recall certainty may be useful in interview‐based studies. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5225981 Tue, 13 Sep 2011 04:00:00 +0100 5225981 http://www.medworm.com/index.php?rid=5225980&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2235 ConclusionAbout one in four APAP users have a PMDD > 4 g/day, whereas 2–3% have a PMDD > 10 g based exclusively on prescription data, which is concerning. These proportions could reduce by over half if the maximum APAP strength in combination prescriptions is 325 mg. Additional monitoring of opioid prescription‐patterns, physician and pharmacist cognizance in prescribing APAP‐containing combination products, and dose‐reduction strategies should be considered to reduce APAP overuse. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5225980 Tue, 13 Sep 2011 04:00:00 +0100 5225980 http://www.medworm.com/index.php?rid=5250869&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2251 ConclusionsWe recommend using the SD or the KS distance to quantify the balance of confounder distributions when applying PS methods. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5250869 Thu, 01 Sep 2011 04:00:00 +0100 5250869 http://www.medworm.com/index.php?rid=5238002&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2244 ConclusionsDifferences in quantity and submission practice of spontaneous reports should be noted for potential comparison among these countries/regions, as well as with those from Western countries, even after the full implementation of national data mining system. Nationwide claims databases with nearly 100% coverage are great assets for pharmacovigilance and pharmacoepidemiology and can be major contributors to global pharmacovigilance. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5238002 Thu, 01 Sep 2011 04:00:00 +0100 5238002 http://www.medworm.com/index.php?rid=5225976&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2249 ConclusionsThe accurate timing of clinical onset and diagnosis in the GPRD, at least of esophageal cancer in women, may require the review of clinical records or future linkage to cancer registries. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5225976 Thu, 01 Sep 2011 04:00:00 +0100 5225976 http://www.medworm.com/index.php?rid=5162021&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2163 (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5162021 Sat, 27 Aug 2011 15:25:50 +0100 5162021 http://www.medworm.com/index.php?rid=5162014&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2215 ConclusionsThis algorithm, consisting of a combination of ICD‐9‐CM diagnosis and CPT‐4 codes, could be used in future safety studies to evaluate GI perforation risk factors in RA patients. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5162014 Sat, 27 Aug 2011 15:25:22 +0100 5162014 http://www.medworm.com/index.php?rid=5162015&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2221 ABSTRACTRegistration of randomized clinical trials has become standard practice and is enforced through publication policies and governmental regulations. However, the registration of observational studies remains controversial. In this commentary, we propose that a compromise can be reached on which observation should be registered based on study design and study intent. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5162015 Wed, 24 Aug 2011 23:00:00 +0100 5162015 http://www.medworm.com/index.php?rid=5162018&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2203 ConclusionsThe proposed list of codes can be used to accurately identify CKD when serum creatinine data are limited. The most sensitive approach for the detection of CKD is to use this list to supplement creatinine measures. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5162018 Tue, 23 Aug 2011 23:00:00 +0100 5162018 http://www.medworm.com/index.php?rid=5162017&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2228 ConclusionsIncreased airway inflammation was associated with lower ICS adherence, which underlines the need of good adherence to reach disease control. Our results suggest that by improving knowledge, especially in ethnic minorities, and by stimulating positive parental perception towards the nature of the disease, the characteristics of the prescribed drugs and the use of medications, better adherence and as a result better asthma control could be reached. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5162017 Tue, 23 Aug 2011 23:00:00 +0100 5162017 http://www.medworm.com/index.php?rid=5162016&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2223 ConclusionsAs a surveillance tool, SDS performs differently depending on whether its intended regulatory target is to narrow relative risk estimates or to confirm/rule out absolute levels of excess risk. These desired endpoints, in addition to the number of exposures available for analysis and the underlying HOI rates, influence the number of products that would be viable candidates for SDS. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5162016 Tue, 23 Aug 2011 23:00:00 +0100 5162016 http://www.medworm.com/index.php?rid=5162020&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2226 ConclusionsPrescriptions for noncurrent treatment, duplicates and missing prescriptions are common in both the ML in the electronic medical record and the list on prescriptions stored in the Swedish National Prescription Repository. Patients with CHF had more discrepancies in the ML. The risk for medication errors in primary care due to incorrect information on prescribed treatment may be substantial. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5162020 Sun, 21 Aug 2011 23:00:00 +0100 5162020 http://www.medworm.com/index.php?rid=5162019&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2217 ConclusionsHealth plan administrative and claims data can be used to accurately identify pre‐gestational and gestational diabetes and ultrasounds. Obesity is not consistently coded. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5162019 Sun, 21 Aug 2011 23:00:00 +0100 5162019 http://www.medworm.com/index.php?rid=5144089&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2204 ConclusionsThe choice of method and definitions, particularly regarding the management of overlapping supplies and the length of observation period, has a substantial impact on estimates of refill adherence to statins. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5144089 Thu, 18 Aug 2011 23:00:00 +0100 5144089 http://www.medworm.com/index.php?rid=5144088&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2213 ConclusionsOver the last decade, the general practice of prescribing SGAs has increased whereas first‐generation antipsychotic prescriptions have declined. By 2007, patients with schizophrenia were prescribed antipsychotics for greater proportions of time, perhaps reflecting the greater acceptability of SGAs or a shift from secondary to primary care prescription. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5144088 Thu, 18 Aug 2011 23:00:00 +0100 5144088 http://www.medworm.com/index.php?rid=5144091&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2219 ConclusionsModels assessing bleeding risk with warfarin should take account of the range of potentially harmful medicine combinations used in elderly people with comorbid conditions. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5144091 Tue, 16 Aug 2011 23:00:00 +0100 5144091 http://www.medworm.com/index.php?rid=5144090&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2209 ConclusionCompliance with the request of the CHMP to conduct studies is very good. The review identified the need for careful consideration of the necessity of studies and of timely dialogue on protocols in advance of a CHMP opinion. The need for expertise and capacity within the EU for the conduct of post‐authorisation studies is confirmed. ENCePP as a transparency and excellence network and as an initiative to build research capacity will enhance post‐authorisation medicines research. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5144090 Tue, 16 Aug 2011 23:00:00 +0100 5144090 http://www.medworm.com/index.php?rid=5109652&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2195 ConclusionThe proposed indication hierarchy provided new insight into prescription patterns of statins. The method can be implemented for other drug categories and could be useful for studying trends in drug utilization, differential drug adherence, and cross‐national comparisons. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5109652 Sun, 07 Aug 2011 23:00:00 +0100 5109652 http://www.medworm.com/index.php?rid=5109651&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2202 ConclusionIn conclusion, this population‐based cohort study found that concomitant use of clopidogrel and PPI in patients who received dual antiplatelet therapy after ACS was not associated with risk of ACS re‐hospitalization. Together, our study and findings of recently published clinical trials suggest that there was no apparent CV interaction between clopidogrel and PPI in patients who received dual antiplatelet therapy. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5109651 Sun, 07 Aug 2011 23:00:00 +0100 5109651 http://www.medworm.com/index.php?rid=5109650&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2201 ConclusionsMen had higher incidence of hospitalised ICVA than women. AF was the major risk factor for ICVA (more in women than men), followed by smoking. Among AF patients, those under anticoagulant therapy showed a significant reduced risk of first ICVA. Antihypertensive drug discontinuation increased the risk of ICVA among women. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5109650 Sun, 07 Aug 2011 23:00:00 +0100 5109650 http://www.medworm.com/index.php?rid=5109649&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2216 ConclusionPrior cases of HIV/AIDS‐linked HSTCL are uncommon in the existing literature. Multiple case reports of HSTCL in the setting of Crohn's disease treated with anti‐TNF plus thiopurine have been published, but HSTCL is rare, making epidemiologic assessments difficult. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5109649 Sun, 07 Aug 2011 23:00:00 +0100 5109649 http://www.medworm.com/index.php?rid=5088679&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2178 ConclusionPublic understanding of medicine safety, how safety is monitored and how to report suspected ADRs is generally limited despite ADRs being commonly experienced. If awareness of direct patient reporting can be increased, the public appear to be willing to report and to be appropriately selective in reporting. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5088679 Mon, 01 Aug 2011 23:00:00 +0100 5088679 http://www.medworm.com/index.php?rid=5088678&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2205 ConclusionsThe linked databases offer a longitudinal perspective, allowing for observations of health care utilization before, during, and after cancer diagnosis. They create new powerful data resources for the monitoring of post‐approval drug utilization, as well as a framework to explore the (cost‐)effectiveness of new, often expensive, anti‐cancer drugs as used in everyday practice. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5088678 Mon, 01 Aug 2011 23:00:00 +0100 5088678 http://www.medworm.com/index.php?rid=5144087&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2208 ABSTRACTIn recent years, comparative effectiveness research has been more aggressively pursued as a means to improve health care, including systematic reviews and meta‐analyses to inform health policy decision making. Because most clinical trials have pre‐specified approaches to collecting data on efficacy, the value of systematic reviews and meta‐analyses in assessing efficacy outcomes is generally accepted. In contrast, collection of data on adverse events is seldom well structured. Hence, the methodological considerations for comparing adverse events from such non‐aligned sources differ substantially from those for comparing efficacy endpoints.We address several important pitfalls in performing systematic reviews and meta‐analyses on adverse events in clinical trials, and we o... Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5144087 Sun, 31 Jul 2011 23:00:00 +0100 5144087 http://www.medworm.com/index.php?rid=5109648&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2198 ConclusionsThe use of PPI is common among patients receiving antibiotics during hospitalization. The greater risk of CDI in relation to PPI among hospitalizations during which fewer or low‐risk antibiotics were prescribed suggests a potentially clinically relevant interaction between antibiotics and PPI. Further study is needed to elucidate possible mechanisms for the observed effect. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5109648 Sun, 31 Jul 2011 23:00:00 +0100 5109648 http://www.medworm.com/index.php?rid=5088677&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2218 ConclusionsPatient‐reported doses of acetaminophen are good risk indicators for acetaminophen overdose patients in Malaysia. Patient‐reported ingestion of ≥8 g (as a cut‐off dose) had a higher sensitivity than ≥10 g or ≥12 g. The results of this study have important implications for toxicity risk evaluations in areas with poor serum acetaminophen assay availability. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5088677 Sun, 31 Jul 2011 23:00:00 +0100 5088677 http://www.medworm.com/index.php?rid=5079685&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2211 ConclusionThe concomitant use of psychotropic drugs with anti‐dementia drugs was extensive, especially among women. Co‐medication with potentially interacting drugs occurred at a rate of one in 10. The concomitant use of anti‐dementia drugs with psychotropic drugs identified in this study may inform the ongoing clinical debate about drug use in this patient group. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5079685 Sun, 31 Jul 2011 23:00:00 +0100 5079685 http://www.medworm.com/index.php?rid=5079686&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2188 ConclusionsWe conclude that measures for balance are useful for reporting the amount of balance reached in propensity score analysis and can be helpful in selecting the final PS model. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5079686 Thu, 28 Jul 2011 23:00:00 +0100 5079686 http://www.medworm.com/index.php?rid=5070371&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2214 ConclusionsPolypharmacy was found to be common within these restricted drug categories for the older persons. MUI provides a convenient approach to summarizing drug usage and will be useful in detecting trends and regional differences and determining the impact of interventions. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5070371 Thu, 28 Jul 2011 03:00:35 +0100 5070371 http://www.medworm.com/index.php?rid=5079688&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2192 ConclusionsThe striking differences in total antibiotic use and the extensive use of the oral agents in some ICUs may indicate room for improvement. As none of the antibiotic policy elements were accompanied by lower antibiotic use in the pooled analysis, it suggests that—beside the ICU category—other unrevealed factors determine antibiotic use. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5079688 Wed, 27 Jul 2011 23:00:00 +0100 5079688 http://www.medworm.com/index.php?rid=5079687&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2181 ConclusionsOf antidepressants studied, only mirtazapine had a statistically significantly greater SD/VA risk versus paroxetine. However, baseline differences between these users suggest that this finding may be attributable to residual confounding. Eleven other antidepressants had SD/VA risks no greater than that of paroxetine, thereby providing reassurance regarding the comparative cardiovascular safety of antidepressants. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5079687 Wed, 27 Jul 2011 23:00:00 +0100 5079687 http://www.medworm.com/index.php?rid=5070374&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2185 ConclusionsAfter outcome readjudication, ZODIAC found no difference in the risk of sudden death among those randomized to ziprasidone versus olanzapine. However, unlike hospital‐based studies, fatal events in general population studies often occur outside hospital and often lack the clinical detail needed for the exact determination of symptom onset and event. Epidemiological evaluations of sudden death need to consider the limitations of the available data. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5070374 Tue, 26 Jul 2011 23:00:00 +0100 5070374 http://www.medworm.com/index.php?rid=5070372&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2212 ConclusionsIn general, participants preferred condensed, plain information in a clear and moderately colored design, but preferences towards drug information are affected by age and level of education. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5070372 Tue, 26 Jul 2011 23:00:00 +0100 5070372 http://www.medworm.com/index.php?rid=5063961&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2176 ConclusionsThe study provides evidence that at least some of our earlier estimates were subject to confounding. Nevertheless, thiazide prescription remains associated with an increased risk of first fall, and this effect is strongest in the first 3 weeks of prescription. Our study demonstrates that the case series method provides an effective way to assess the extent of residual confounding in case–control studies. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5063961 Tue, 26 Jul 2011 17:22:28 +0100 5063961 http://www.medworm.com/index.php?rid=5063959&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2193 ConclusionsThe knowledge level on the voluntary reporting system among physicians and pharmacists in Venezuela is poor. These results strengthen the hypothesis that being unaware of the adverse effects of medicines and not knowing the existence of a PhV system is a major cause of underreporting. A careful study of the actual knowledge of PhV could be the basis to set up interventions specifically designed to overcome misleading concepts and to improve the reporting rate at a national level. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5063959 Tue, 26 Jul 2011 17:22:03 +0100 5063959 http://www.medworm.com/index.php?rid=5063960&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2189 ConclusionsExposure to antipsychotic mediations was extensive. Although these children may have had complex and severe problems, additional research is urgently needed on the benefits and risks of long‐term antipsychotic exposure among very young children. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5063960 Mon, 25 Jul 2011 23:00:00 +0100 5063960 http://www.medworm.com/index.php?rid=5039932&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2184 ConclusionAvoidable inconsistencies in study design and reporting attenuate conclusions that can be drawn from the literature on antenatal drug utilization. Nevertheless, the body of published research shows that antenatal prescription drug use is common, with many studies finding that a majority of women use one or more prescription medicine during pregnancy. Similarly, studies consistently report the use of drugs recognized as having potential risks in pregnancy. Given this widespread use, it is particularly important to develop standards for calculating and reporting antenatal exposures to improve the value of future research in this area. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5039932 Tue, 19 Jul 2011 23:00:00 +0100 5039932 http://www.medworm.com/index.php?rid=5039934&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2194 ConclusionsExcept for an increased risk of late transient hypoglycemia, we found no increased risks of adverse birth outcomes among infants exposed to neuraminidase inhibitors in fetal life compared with the unexposed. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5039934 Mon, 18 Jul 2011 23:00:00 +0100 5039934 http://www.medworm.com/index.php?rid=5039933&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2199 ConclusionsResults indicate that the IMB safety warnings had inconsistent effects on the rate of prescribing of drugs considered. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5039933 Mon, 18 Jul 2011 23:00:00 +0100 5039933 http://www.medworm.com/index.php?rid=5039935&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2186 ConclusionsPatients with epilepsy exhibit increased risk of MI, stroke, cardiovascular death, and all‐cause death. Compared with carbamazepine monotherapy, valproate may decrease, and oxcarbazepine and phenobarbital may increase, the risk of adverse cardiovascular events in these patients. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5039935 Sun, 17 Jul 2011 23:00:00 +0100 5039935 http://www.medworm.com/index.php?rid=5030626&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2190 ConclusionsOpioid use featured significant quantitative and qualitative differences between provinces in Canada and showed an overall increasing trend mainly driven by changes in “strong opioids” in the study period. Reasons for the observed differences are not clear yet require systematic examination to allow evidence‐based interventions in the interest of equitable pain treatment as well as the reduction of high levels of opioid‐related morbidity and mortality in Canada. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5030626 Tue, 12 Jul 2011 23:00:00 +0100 5030626 http://www.medworm.com/index.php?rid=5020967&cid=s_33614_13_f&fid=33614&url=http%3A%2F%2Fdx.doi.org%2F10.1002%252Fpds.2176 ConclusionsThe study provides evidence that at least some of our earlier estimates were subject to confounding. Nevertheless, thiazide prescription remains associated with an increased risk of first fall, and this effect is strongest in the first 3 weeks of prescription. Our study demonstrates that the case series method provides an effective way to assess the extent of residual confounding in case–control studies. Copyright © 2011 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety) Pharmacoepidemiology and Drug Safety journals http://www.medworm.com/rss/comments.php?id=5020967 Sun, 10 Jul 2011 23:00:00 +0100 5020967