MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Photodiagnosis and Photodynamic Therapy' source. Sat, 20 Mar 2010 16:12:40 +0100 http://www.medworm.com/index.php?rid=3365879&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100010000037%2Fabstract%3Frss%3Dyes (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3365879 Tue, 02 Mar 2010 00:00:00 +0100 3365879 http://www.medworm.com/index.php?rid=3365867&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100010000104%2Fabstract%3Frss%3Dyes (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3365867 Mon, 01 Mar 2010 00:00:00 +0100 3365867 http://www.medworm.com/index.php?rid=3365869&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100010000074%2Fabstract%3Frss%3Dyes The objective of this study was to develop an applicator for delivery of light and monitoring of photodynamic therapy (PDT) in the anal cavity for treatment of anal intraepithelial neoplasia grade III (AIN III), which can progress to invasive anal cancer.Forty-eight hours before treatment, patients participating in the study were injected with 0.03 (n=2) or 0.075 (n=2)mgkg−1 m-THPC. For light delivery and monitoring of PDT, an applicator based on standard anoscopy equipment was developed which facilitates, in addition to a light treatment fiber, fiber optic probes to monitor blood saturation, blood volume, fluorescence and fluence (rate) at two different locations in situ. Patients were given a light dose of 10–17Jcm−2 at a fluence rate of 45–50mWcm−2 based on in situ measured li... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3365869 Mon, 22 Feb 2010 00:00:00 +0100 3365869 http://www.medworm.com/index.php?rid=3365868&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100010000062%2Fabstract%3Frss%3Dyes Surgical Site Infection is defined as an infection of the tissues within or around the surgical wound that develops within 30 days after an operation . Many such infections are initiated by pyogenic organisms which are implanted into the wound at operation. Alternatively the surgical wound can become secondarily contaminated and be invaded by pathogens. In either event the SSI becomes a major cause of protracted recovery, and/or disabling morbidity, which in some cases lead to fatal outcome, after an otherwise successful operation. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3365868 Thu, 18 Feb 2010 00:00:00 +0100 3365868 http://www.medworm.com/index.php?rid=3365878&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100010000050%2Fabstract%3Frss%3Dyes (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3365878 Mon, 15 Feb 2010 00:00:00 +0100 3365878 http://www.medworm.com/index.php?rid=3365874&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100010000049%2Fabstract%3Frss%3Dyes Conclusions: ALA PDT is a simple, safe and effective therapeutic option for the treatment of severe acne. Further studies to fully understand its mechanisms and optimize its effectiveness are needed. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3365874 Mon, 08 Feb 2010 00:00:00 +0100 3365874 http://www.medworm.com/index.php?rid=3365873&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001677%2Fabstract%3Frss%3Dyes Conclusion: Physicians treating NMSC should have access to PDT and be trained and experienced in its use. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3365873 Mon, 08 Feb 2010 00:00:00 +0100 3365873 http://www.medworm.com/index.php?rid=3365871&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100010000025%2Fabstract%3Frss%3Dyes Sally Ibbotson and Alexis Sidoroff are to be congratulated on their clear and concise accounts of the place of Photodynamic Therapy (PDT) in the treatment of cutaneous pathology. Many dermatologists present patients with a list of possible treatments and ask them to make a choice. Sally Ibbotson and Alexis Sidoroff both forcibly make the point that the treatments are not interchangeable and that there are specific indications for each treatment although there is inevitably some overlap. These papers provide the clinician with sufficient understanding of the issues involved to confidently advise his patient of the optimum treatment for his condition. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3365871 Mon, 18 Jan 2010 00:00:00 +0100 3365871 http://www.medworm.com/index.php?rid=3365876&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001690%2Fabstract%3Frss%3Dyes Conclusion: The properly selected wavelength and intensity of light beam were incident with great precision so that they would not affect unwanted cells, but inflamed activated cells were suppressed due to intense light energy following Methotrexate injection. Without invasion, IR LED PDT showed an effective and cheaper treatment solution for RA. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3365876 Fri, 15 Jan 2010 00:00:00 +0100 3365876 http://www.medworm.com/index.php?rid=3365875&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001689%2Fabstract%3Frss%3Dyes Conclusion: Photodynamic diagnosis using oral 5-ALA and subsequent treatment of upper tract urothelial tumours is safe and feasible with additional advantages of detecting lesions not visualised on conventional white light endoscopy. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3365875 Fri, 15 Jan 2010 00:00:00 +0100 3365875 http://www.medworm.com/index.php?rid=3365870&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001707%2Fabstract%3Frss%3Dyes Summary: Photodynamic Diagnosis (PDD) and Therapy (PDT) are modern methods which are evaluated in different fields in gynaecology. PDT has been successfully evaluated in human papillomavirus-related (HPV) genital dysplasia like CIN and VIN. The aim of this review is to give an overview about current applications. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3365870 Mon, 11 Jan 2010 00:00:00 +0100 3365870 http://www.medworm.com/index.php?rid=3365872&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001641%2Fabstract%3Frss%3Dyes This article is a review of the use of topical photodynamic therapy in dermatology and its current role in 2009 and future developments. The content of this article was presented at the EPPM in Wroclaw, September 2009. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3365872 Wed, 30 Dec 2009 00:00:00 +0100 3365872 http://www.medworm.com/index.php?rid=3365877&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001653%2Fabstract%3Frss%3Dyes Conclusions: Combined HDR/PDT treatment for endobronchial tumors is well tolerated and can achieve prolonged local control with acceptable morbidity when PDT follows HDR and when the spacing between treatments is 1 month or less. This treatment regimen should be studied in a larger patient population. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3365877 Mon, 28 Dec 2009 00:00:00 +0100 3365877 http://www.medworm.com/index.php?rid=3018658&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001392%2Fabstract%3Frss%3Dyes (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018658 Fri, 20 Nov 2009 00:00:00 +0100 3018658 http://www.medworm.com/index.php?rid=3018655&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001331%2Fabstract%3Frss%3Dyes Chondrosarcoma is a malignancy that is cartilaginous in origin and represents approximately 25% of all primary osseous neoplasms. Chondrosarcomas are rare with 90 new cases a year reported in the UK. Of these, only 10% occur in the head and neck. Peak incidence is between the ages of 30–50, with no apparent correlation with gender . (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018655 Fri, 20 Nov 2009 00:00:00 +0100 3018655 http://www.medworm.com/index.php?rid=3018654&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001367%2Fabstract%3Frss%3Dyes The future of PDT will build on our scientific and clinical success, expand to new horizons but, most importantly, will question and, I believe, significantly modify what we currently accept and term PDT. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018654 Fri, 20 Nov 2009 00:00:00 +0100 3018654 http://www.medworm.com/index.php?rid=3018651&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001422%2Fabstract%3Frss%3Dyes Summary: Background: Photodynamic therapy is an established cancer treatment in which a photosensitizing agent is activated by exposure to light thus generating cytotoxic reactive oxygen species that cause cellular damage.Methods: A new photosensitizer synthesized at Curie Institute was used to treat retinoblastoma xenografts in mice, a glycoconjugated meso substituted porphyrin derivative, that showed some retinoblastoma cell affinity. The longitudinal follow-up of the tumors was carried out by 23Na MRI (without adding exogenous contrast agents) to map the extracellular compartment and to characterize cell packing. Two regimens were followed to target either blood vessels alone or blood vessels and cancer cells simultaneously.Results and conclusions: Only the protocol targeting both cance... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018651 Fri, 20 Nov 2009 00:00:00 +0100 3018651 http://www.medworm.com/index.php?rid=3018652&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001379%2Fabstract%3Frss%3Dyes Conclusions: Protoporphyrin-IX is a potentially useful tumor-staining molecular agent for fluorescent location of cancer cell in sputum samples from lung cancer patients. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018652 Thu, 19 Nov 2009 00:00:00 +0100 3018652 http://www.medworm.com/index.php?rid=3018646&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001410%2Fabstract%3Frss%3Dyes Summary: Photodynamic therapy (PDT) was discovered over 100 years ago by observing the killing of microorganisms when harmless dyes and visible light were combined in vitro. Since then it has primarily been developed as a treatment for cancer, ophthalmologic disorders and in dermatology. However, in recent years interest in the antimicrobial effects of PDT has revived and it has been proposed as a therapy for a large variety of localized infections. This revival of interest has largely been driven by the inexorable increase in drug resistance among many classes of pathogen. Advantages of PDT include equal killing effectiveness regardless of antibiotic resistance, and a lack of induction of PDT resistance. Disadvantages include the cessation of the antimicrobial effect when the light is tur... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018646 Thu, 19 Nov 2009 00:00:00 +0100 3018646 http://www.medworm.com/index.php?rid=3018656&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001380%2Fabstract%3Frss%3Dyes (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018656 Mon, 16 Nov 2009 00:00:00 +0100 3018656 http://www.medworm.com/index.php?rid=3018653&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS157210000900132X%2Fabstract%3Frss%3Dyes Conclusion: Adjuvant repetitive PDT seems to offer an excellent local control of metastatic brain carcinomas with about 79% of patients succumb to the primary and only two out of fourteen died of brain recurrence with the best results obtained in lung cancer. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018653 Mon, 16 Nov 2009 00:00:00 +0100 3018653 http://www.medworm.com/index.php?rid=3018645&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001409%2Fabstract%3Frss%3Dyes Summary: In the face of increasing multi-drug resistant bacteria, both in healthcare and the community, new drugs or novel methods of decontamination are required. The use of light-activated drugs – photoantimicrobials – has been promoted at various points during the past decade or more but has not yet gained meaningful clinical acceptance. Photoantimicrobials offer advantages over conventional drugs in attacking bacteria at various sites, rather than just one, and in the intermediacy of reactive oxygen species, against which there is little possibility of resistance. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018645 Mon, 16 Nov 2009 00:00:00 +0100 3018645 http://www.medworm.com/index.php?rid=3018648&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001355%2Fabstract%3Frss%3Dyes Conclusions: Preliminary results indicate that PDT+PDL is safe and may offer improved PWS treatment efficacy. Additional studies are warranted. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018648 Fri, 13 Nov 2009 00:00:00 +0100 3018648 http://www.medworm.com/index.php?rid=3018657&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001343%2Fabstract%3Frss%3Dyes This joint meeting began with an opening ceremony on September 4th in the magnificent Aula of the University of Wroclaw. Professor Piotr Ziolkowski, Chairman of the local organising committee welcomed delegates and guests, following which there was a reception in which all present had the opportunity to renew old friendships. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018657 Mon, 09 Nov 2009 00:00:00 +0100 3018657 http://www.medworm.com/index.php?rid=3018650&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001306%2Fabstract%3Frss%3Dyes Summary: Photodynamic therapy (PDT) is based on the association of a light source and light sensitive agents in order to cause the selective death of tumor cells. To evaluate topical 5-aminolaevulinic acid (5-ALA) and diode laser photodynamic single session therapy single session for non-melanoma skin cancer (NMSC), a long-term follow-up was performed. Nineteen Bowen's disease (BD) and 15 basal cell carcinoma (BCC) lesions were submitted to 6-h topical and occlusive 20% 5-ALA plus DMSO and EDTA, and later were exposed to 630nm diode laser, 100 or 300Jcm−2 dose. At 3 months tumor-free rate was 91.2% (31/34) whereas at 60 months, 57.7% (15/26), slightly higher in BCC (63.6%; 7/11). The relation between the reduction of the clinical response and the increase of tumor dimension observed at 1... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018650 Fri, 16 Oct 2009 00:00:00 +0100 3018650 http://www.medworm.com/index.php?rid=3018649&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS157210000900129X%2Fabstract%3Frss%3Dyes Summary: Treatment of 5,10,15,20-tetra(pentafluorophenyl) porphyrins with polyethylene glycol (PEG) halides and sodium sulfide is a mild and efficient route to water-soluble PEG substituted porphyrins. The method has been used to access a series of free-base and metallated PEG porphyrins, which have been investigated for photodynamic activity against Human Caucasian colon adenocarcinoma (Caco2) cells. Toxicity, in the presence and absence of light, is shown to be affected by the length of the PEG chain, nature of coordinated metal and axial ligand. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018649 Mon, 12 Oct 2009 00:00:00 +0100 3018649 http://www.medworm.com/index.php?rid=3018642&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001318%2Fabstract%3Frss%3Dyes It has been said that the hallmark of a good study is that it should not only address a fundamentally important question, but that it should leave several additional questions unanswered, providing fertile ground for future research. The report by Moghissi et al. does indeed address an important question related to the management of early stage esophageal malignancy. Although the background to this challenging clinical entity is well discussed in the “literature review” component of this paper, it is worth reiterating a number of key issues. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018642 Mon, 05 Oct 2009 00:00:00 +0100 3018642 http://www.medworm.com/index.php?rid=3018647&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001288%2Fabstract%3Frss%3Dyes Summary: Port wine stain (PWS) birthmarks are congenital vascular malformations characterized by ectatic capillaries in the papillary layer of the dermis. They usually appear at birth and tend to become darker and thicker with age. Cosmetic and pathological changes can cause great depression in all ages. Laser-mediated selective photothermolysis is the treatment of choice but vascular-targeted photodynamic therapy (PDT) might be an alternative approach in the treatment of PWS. PDT has shown therapeutic benefit in pink and resistant lesions. In theory, vascular-targeted PDT may be more efficient in terms of better lightening and less treatment sessions than pulsed dye laser (PDL) irradiation. Chinese clinicians have gained profound knowledge and accumulated a large body of clinical experien... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018647 Fri, 11 Sep 2009 00:00:00 +0100 3018647 http://www.medworm.com/index.php?rid=3018643&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001240%2Fabstract%3Frss%3Dyes The management of early cancer of the oesophagus is now an area of intense discussion. A vital contribution appears in this issue with the important concluding statement that ‘endoscopic PDT should be considered the treatment of choice in patients with early oesophageal cancer who are ineligible for surgical resection.’ This conclusion must provoke a full discussion and detailed examination. The authors correctly call for a more information in a cohort study: but what of resolving the issue with a randomised trial. What of PDT for the treatment of early cancer in patients who are eligible for surgery. Currently there are proposals among the Barrett's Esophagus Ablation Trial (BEAT) group to look at trial of surgery versus endotherapy (endoscopic mucosal resection alone or combined with... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018643 Mon, 07 Sep 2009 00:00:00 +0100 3018643 http://www.medworm.com/index.php?rid=3018641&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001458%2Fabstract%3Frss%3Dyes (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018641 Tue, 01 Sep 2009 00:00:00 +0100 3018641 http://www.medworm.com/index.php?rid=3018644&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001008%2Fabstract%3Frss%3Dyes Conclusion: Endoscopic PDT should be considered as the treatment of choice in patients with EOCa who are ineligible for surgical resection. We suggest that a carefully designed study of a cohort of patients with EOCa comparing surgical resection with endoscopic PDT is warranted. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=3018644 Tue, 25 Aug 2009 00:00:00 +0100 3018644 http://www.medworm.com/index.php?rid=2708525&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000994%2Fabstract%3Frss%3Dyes (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708525 Tue, 11 Aug 2009 23:00:00 +0100 2708525 http://www.medworm.com/index.php?rid=2708524&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000817%2Fabstract%3Frss%3Dyes (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708524 Tue, 11 Aug 2009 23:00:00 +0100 2708524 http://www.medworm.com/index.php?rid=2708523&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000659%2Fabstract%3Frss%3Dyes (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708523 Tue, 11 Aug 2009 23:00:00 +0100 2708523 http://www.medworm.com/index.php?rid=2708521&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000829%2Fabstract%3Frss%3Dyes (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708521 Tue, 11 Aug 2009 23:00:00 +0100 2708521 http://www.medworm.com/index.php?rid=2708540&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000647%2Fabstract%3Frss%3Dyes Around 300 participants from more than 20 different countries and regions travelled to Seattle, USA in June to attend the 12th International Photodynamic Association (IPA) World Congress. This was co-organised locally by SPIE. This Congress followed in the great tradition of these biennial conferences which routinely attract leading clinical and scientific researchers in the fields of photodynamic therapy (PDT) and photodiagnosis (PD) alike. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708540 Sun, 09 Aug 2009 23:00:00 +0100 2708540 http://www.medworm.com/index.php?rid=2708522&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000830%2Fabstract%3Frss%3Dyes The 13th bi-annual conference of the ESP, in conjunction with the 2nd congress of the EPPM is a great occasion for both scientists and clinicians concerned with PDPDT. The meeting in Wroclaw has provided this opportunity for the two organisations to join together from 5th to 10th September. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708522 Sun, 09 Aug 2009 23:00:00 +0100 2708522 http://www.medworm.com/index.php?rid=2708520&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000842%2Fabstract%3Frss%3Dyes In retrospect, papers and talks concerning new frontiers were too often distorted by inaccuracy or sensationalism. In an attempt at prognostic relevance I believe that the frontiers of PDT will involve nanotechnology and stem cells, both or neither, with a strong bet placed on serendipity. Further, while currently PDT is practiced with separate drug and light, ultimately leading to a type II PDR, this may not be the case in the future. Let us take a look in the crystal ball. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708520 Sun, 09 Aug 2009 23:00:00 +0100 2708520 http://www.medworm.com/index.php?rid=2708519&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000611%2Fabstract%3Frss%3Dyes Summary: Terahertz imaging has progressed significantly over the last decade and there is now a significant body of research in its application to biomedical problems with the possibility of developing it into viable medical imaging modality in the future. The motivation being to fill some of the shortfalls in existing medical imaging technologies especially in detecting early stage cancers. We review the main developments in terahertz imaging to-date and highlight the most promising current areas of biomedical terahertz research. Additionally, we provide an overview of the principles behind terahertz imaging along with illustrated examples to aid understanding for those new to the technology. Our aim is to increase awareness of the existence and potential of the technology and inspire sol... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708519 Sun, 09 Aug 2009 23:00:00 +0100 2708519 http://www.medworm.com/index.php?rid=2708518&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000581%2Fabstract%3Frss%3Dyes Conclusions: mTHPC-mediated photo-cytotoxicity can effectively induce early apoptotic responses in NPC/HK1 cells which might be modulated by mitochondrial damages and Bcl-2 inhibition. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708518 Sun, 09 Aug 2009 23:00:00 +0100 2708518 http://www.medworm.com/index.php?rid=2708511&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS157210000900057X%2Fabstract%3Frss%3Dyes Cholangiocarcinoma is a disease that is challenging to both diagnose and treat. Only a minority of patients present at a stage suitable for attempted curative surgical resection and 5 year survival rates remain as low as 5% in most series . Much of the morbidity of cholangiocarcinoma is caused by complications of biliary obstruction—a rationale for treatments such as PDT, which aim to optimise biliary drainage and thereby improve survival and quality of life. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708511 Sun, 09 Aug 2009 23:00:00 +0100 2708511 http://www.medworm.com/index.php?rid=2708509&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000623%2Fabstract%3Frss%3Dyes This article is a review of laboratory and clinical research undertaken in Poland in PDD and PDT over the past 20 years. These are divided into two parallel research areas. The first is based on clinical trials where new modalities of photosensitizer synthesis, molecular mechanisms of PDT and other aspects are investigated. The second is concerned with clinical aspects of PDD and PDT in both pre-neoplastic and malignant disease. In Poland there were 2 National Congresses in 2006 and 2008 with 100 and 400 participants respectively. One of the oldest centers of Photodynamic Diagnostics and Therapy is located in Bytom. For about 10 years it has led clinical research in Poland with PDD and PDT in such medical disciplines as dermatology, gastroenterology, laryngology, pulmonology, gynecology, a... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708509 Sun, 09 Aug 2009 23:00:00 +0100 2708509 http://www.medworm.com/index.php?rid=2708510&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000635%2Fabstract%3Frss%3Dyes Summary: A brief history of photodynamic therapy in Wroclaw was presented in this paper. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708510 Sun, 02 Aug 2009 23:00:00 +0100 2708510 http://www.medworm.com/index.php?rid=2708517&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS157210000900060X%2Fabstract%3Frss%3Dyes In conclusion, ICG when used in combination with near-infrared light showed a very fast (within 3h) and persistent (up to 48h) photo-toxic effect on MDA-MB231 human breast cancer cells. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708517 Thu, 30 Jul 2009 23:00:00 +0100 2708517 http://www.medworm.com/index.php?rid=2708513&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000593%2Fabstract%3Frss%3Dyes This study should permit to go further in the establishment of PDT as a standard procedure in patients with unresectable CC, and to try and understand the mechanisms by which PDT enables such a dramatic improvement of survival and quality of life in these patients. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708513 Wed, 29 Jul 2009 23:00:00 +0100 2708513 http://www.medworm.com/index.php?rid=2708539&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000556%2Fabstract%3Frss%3Dyes On 15 May 2009 the Annual Scientific Meeting of the UK-PDPDT interest group was held in Salisbury District General Hospital. K. Moghissi, the co-ordinator of the group, welcomed the participants. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708539 Wed, 15 Jul 2009 23:00:00 +0100 2708539 http://www.medworm.com/index.php?rid=2708516&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000544%2Fabstract%3Frss%3Dyes Conclusion: ICG/PDT can efficiently and rapidly induce apoptosis in human melanoma cells and it can be considered as a new therapeutic approach for topical treatment of melanoma. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708516 Sun, 12 Jul 2009 23:00:00 +0100 2708516 http://www.medworm.com/index.php?rid=2708514&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000568%2Fabstract%3Frss%3Dyes Photofrin (hematoporphyrin derivative or porfimer sodium), Visudyne (benzoporphyrin derivative monoacid ring A or verteporfin), Foscan (meta-tetra(hydroxyphenyl)chlorin or Temoporfin), Levulan Kerastick (5-aminolevulinic acid), Metivx (methyl aminolevulinate) and Hexvix (hexyl aminolevulinate) are the most studied and best known photosensitizers and photosensitizer precursors approved for clinical use in photodynamic therapy (PDT) or photodiagnosis in many countries worldwide. Many new photosensitizers and precursors are continuously synthesized and investigated in laboratories, some of them in clinical trials and some are even approved in single countries. Side effects of the present photosensitizers and their specificities are the main reasons for designing new drugs for specific neoplas... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708514 Thu, 02 Jul 2009 23:00:00 +0100 2708514 http://www.medworm.com/index.php?rid=2708515&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000349%2Fabstract%3Frss%3Dyes Conclusions: In general, results of the experimental study of biodistribution of Photolon® in inner organs and tissues of rats, performed as in real time (by means of intravital laser fluorimetry in situ) as ex vivo (spectrophotometric assay) can be utilized while optimizing existing regimens of PDT with the purpose to increase safety and efficacy of treatment as well as for the development of new PDT protocols with Photolon® applied for new indications. Parameters of pharmacokinetics and biodistribution of Photolon®/Fotolon® as well as its’ ability to cross an intact blood–brain barrier, are optimal for the majority of modern clinical applications of PDT. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708515 Sun, 21 Jun 2009 23:00:00 +0100 2708515 http://www.medworm.com/index.php?rid=2708512&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000532%2Fabstract%3Frss%3Dyes Summary: Cholangiocarcinoma (CC) is emerging as an important treatment indication for photodynamic therapy. CCs are generally unresectable locally invasive tumors that occlude the biliary tree leading to fatal cholangitis and liver failure. Biliary decompression via stenting offers symptomatic relief but does not control tumor growth. Founded on an initial case study followed by ever more sophisticated clinical research, including randomized trials, photodynamic therapy has garnered enough momentum to be considered as part of the standard of care for these patients. Further, preliminary clinical data show the potential for benefit of the use of PDT in a neoadjuvant and adjuvant fashion to the minority of patients currently considered resectable or of border line resectability. PDT also imp... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708512 Mon, 08 Jun 2009 23:00:00 +0100 2708512 http://www.medworm.com/index.php?rid=2708538&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000970%2Fabstract%3Frss%3Dyes Endoscopic fluorescence imaging (EFI) has been recently recognized as a useful method to detect early superficial cancers in the tracheo-bronchial tree and the bladder, including flat lesions. In the bronchi, EFI is based on the detection of the tissue autofluorescence, whereas this detection approach is based on exogenously induced fluorescence in the bladder. Indeed, a solution of the hexyl ester of aminolevulinic acid (Hexvix®) is instilled for about 1h in the bladder prior to the examination. The lesions are then enlightened by the fluorescent porphyrins, including protoporphyrin IX, that accumulate very selectively in the cancerous cells. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708538 Sun, 31 May 2009 23:00:00 +0100 2708538 http://www.medworm.com/index.php?rid=2708537&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000969%2Fabstract%3Frss%3Dyes The principle objective in measuring light dose is to help optimise treatment schedules. One of the inherent difficulties associated with PDT is that the biological response does not follow the radiometric light dose in a simple linear manner. Treatment outcome depends on drug uptake and also availability of oxygen, in addition to the added complexity of photobleaching, a phenomenon that means that light delivered in the first minute of treatment is much more effective than the same amount of light delivered at the end. However, its complexity should not deter the investigator from attempting to quantify the effective light dose. This presentation will review different approaches that have been adopted, from the sophisticated to the pragmatic. One of the key components is the concentration... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708537 Sun, 31 May 2009 23:00:00 +0100 2708537 http://www.medworm.com/index.php?rid=2708536&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000957%2Fabstract%3Frss%3Dyes The primary requirement of the combination light source and delivery device used in photodynamic therapy (PDT) is to achieve the desired energy fluence throughout the target tissue volume. Lasers, light sources and the dosimetric parameters to induce controlled photochemical reactions operate below power outputs that would cause any photothermal effects of consequence for photodynamic therapy. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708536 Sun, 31 May 2009 23:00:00 +0100 2708536 http://www.medworm.com/index.php?rid=2708535&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000945%2Fabstract%3Frss%3Dyes Liposomes consist of spherical phospholipid bilayers with number of properties making them useful for topical application of different drugs. Liposomes can be used as carriers for hydrophilic as well as lipophilic therapeutic agents because they show some amphiphilic character. Clinical studies indicated that 5-aminolevulinic acid (ALA) encapsulated in liposomes improved the quality of fluorescence diagnosis by ALA-induced porphyrins and optimized the results of photodynamic therapy (PDT). In our study, the new original approach was to use liposomal formulation of ALA and its methyl ester, metvix, both in vitro and in vivo, and to check whether liposome-entrapped precursors of photosensitizers may induce matrix metalloproteinases (MMPs) in animal tumor model and in other tissues from tumor... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708535 Sun, 31 May 2009 23:00:00 +0100 2708535 http://www.medworm.com/index.php?rid=2708534&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000933%2Fabstract%3Frss%3Dyes In conclusion PDT in dermatology has already gone a long way with some success in its routine clinical application. Yet a long list of necessary steps are still ahead of us: (a) broadening the acceptance and impact (which is made difficult by its position somewhere between conservative treatment modalities and procedures like surgery), (b) further optimizing the treatment procedure and (c) expanding the field of novel indications. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708534 Sun, 31 May 2009 23:00:00 +0100 2708534 http://www.medworm.com/index.php?rid=2708533&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000921%2Fabstract%3Frss%3Dyes The use of topical photodynamic therapy (PDT) is well established for superficial non-melanoma skin cancer and dysplasia. Its application in other indications, including acne vulgaris and a range of other skin diseases, is also of increasing clinical and research interest. Several multicentre comparative studies have established that the efficacy of topical PDT is at least equivalent to that of other non-surgical conventional treatments such as cryotherapy or 5-fluorouracil for the treatment of superficial basal cell carcinoma, Bowen's disease and actinic keratosis but that PDT has superior cosmetic outcome. PDT also has an important role in the treatment of superficial non-melanoma skin cancer and dysplasia in immunosuppressed patients. Pain is a significant problem during the irradiation... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708533 Sun, 31 May 2009 23:00:00 +0100 2708533 http://www.medworm.com/index.php?rid=2708532&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS157210000900091X%2Fabstract%3Frss%3Dyes Background: Photodynamic therapy (PDT) is evolving to be an effective and safe ablative therapy for high grade dysplasia (HGD) within a Barrett's oesophagus. Recent studies suggest that PDT can provide outcomes comparable to oesophagectomy without exposing the patient to the excess risks attached to surgical resection . The aim of this study is to present our experience from the Yorkshire Laser Centre over a 10-year period and report outcomes, technical issues and complications. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708532 Sun, 31 May 2009 23:00:00 +0100 2708532 http://www.medworm.com/index.php?rid=2708531&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000908%2Fabstract%3Frss%3Dyes Brief summary: PDT is a drug and device therapy using photosensitizer drugs activated by laser light for mucosal ablation. Ps-PDT has been used extensively with proven long-term efficacy and durability for the ablation of BE with high-grade dysplasia and early esophageal adenocarcinoma. However, continued use is hampered by an associated stricture risk and prolonged photosensitivity (4–6 weeks). Promising single center European studies using other forms of PDT, such as ALA-PDT, have not been replicated elsewhere, limiting the widespread use of other forms of PDT. Over the past several years other ablation devices, such as radiofrequency energy catheters, have demonstrated equal or better ablation results with fewer side effects, compared with PDT. Future use of PDT in esophageal disease ... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708531 Sun, 31 May 2009 23:00:00 +0100 2708531 http://www.medworm.com/index.php?rid=2708530&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000891%2Fabstract%3Frss%3Dyes Introduction: PD and PDT of cancer are gaining ground in numerous clinical disciplines including cranio-maxillo-facial surgery. In recent years literature presented input from many new applications. This is due to better knowledge about PD-PDT from the clinical staff, both nurses and doctors. But it is also a result of improved drug and hardware especially investigation of better photosensitizers and more efficient light sources. We here focus on some new developments regarding oral cavity, which will be discussed. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708530 Sun, 31 May 2009 23:00:00 +0100 2708530 http://www.medworm.com/index.php?rid=2708529&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS157210000900088X%2Fabstract%3Frss%3Dyes Photodynamic therapy for head and neck cancer is now well established in a few centres in the EU. There are drugs with licensed indications and there are also a number of research programmes that are looking to extend applications. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708529 Sun, 31 May 2009 23:00:00 +0100 2708529 http://www.medworm.com/index.php?rid=2708528&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000878%2Fabstract%3Frss%3Dyes Surgical resection remains the primary option for lung cancer treatment when oncologically the tumour is resectable, clinically the patient is operable and surgically the subject is eligible. However, despite considerable advances in diagnostic methods, surgical and anaesthetic techniques, and immense progress in intensive therapy neither the resectability rate, nor overall outcome for patients with lung cancer has significantly improved. Resectability rate is still ≤20%, and overall survival is around 15–20%. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708528 Sun, 31 May 2009 23:00:00 +0100 2708528 http://www.medworm.com/index.php?rid=2708527&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000866%2Fabstract%3Frss%3Dyes Lung cancer is the leading cause of death from cancer throughout the world, due to the high prevalence of tobacco smoking, the environmental pollution, the aging society and detection of lung cancer at the late stage. It is also due to the treatments being difficult for patients with impaired lung function such as chronic obstructive pulmonary disease (COPD) caused by tobacco smoking. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708527 Sun, 31 May 2009 23:00:00 +0100 2708527 http://www.medworm.com/index.php?rid=2708526&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000854%2Fabstract%3Frss%3Dyes Photodynamic diagnostic (PDD) and therapeutic methods (PDT) have been evaluated successfully in several malignant and non-malignant gynaecologic diseases. Fluorescence diagnosis is currently employed in gynaecologic conditions such as cervical intraepithelial neoplasia (CIN), endometriosis and ovarian cancer. In the field of endometriosis, a frequent pathology where uterine mucosa is found in the abdominal cavity, PDD has been shown to be useful for the detection of active lesions. Regarding ovarian cancer, several studies show that PDD is more effective in the detection of implantation metastases then white light inspection alone. As the quantity of remaining cancerous tissue after ovarian cancer surgery reciprocally correlates with the prognosis of the patient, PDD could be a precious t... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708526 Sun, 31 May 2009 23:00:00 +0100 2708526 http://www.medworm.com/index.php?rid=2708508&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009001033%2Fabstract%3Frss%3Dyes (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2708508 Sun, 31 May 2009 23:00:00 +0100 2708508 http://www.medworm.com/index.php?rid=2504695&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000337%2Fabstract%3Frss%3Dyes Summary: We have more than 10 years experience in the Photobiology Unit, in the use of topical photodynamic therapy (PDT) for non-melanoma skin cancer and other skin diseases. During this time we have undertaken approximately 5000 treatments and this article details the practical aspects of how we treat Bowen's disease with topical PDT. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2504695 Thu, 30 Apr 2009 23:00:00 +0100 2504695 http://www.medworm.com/index.php?rid=2504694&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000313%2Fabstract%3Frss%3Dyes Conclusion: Treatment of VIN lesions using a novel bioadhesive patch induced changes in cell cycle and apoptotic proteins in response to PDT with possible utilisation of apoptotic pathways. The efficacy of PDT in treating VIN could be improved by a better understanding of these apoptotic mechanisms, the influence of factors, such as HPV status, and of the need for effective pain management. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2504694 Thu, 30 Apr 2009 23:00:00 +0100 2504694 http://www.medworm.com/index.php?rid=2504693&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000325%2Fabstract%3Frss%3Dyes Summary: Objective: We aimed to clarify the optimal timing for the fluorescence imaging of brain tumor tissue differentiated from brain edema after the administration of photosensitizers.Methods: We have performed an in vivo study of the kinetics of 5-aminolevulinic acid (5-ALA) in comparison with talaporfin sodium using the rat brain tumor model and rat vasogenic edema model produced by cold injury. The in vivo kinetics of 5-ALA and talaporfin sodium in brain tumor model and the vasogenic edema model was determined by a fluorescence macroscope and a microplate reader.Results: The in vivo kinetic study of 5-ALA showed mild fluorescence intensity of protoporphyrin IX (PpIX) in brain tumor differentiated from vasogenic edema. The mean lesion-to-normal-brain ratio (L/N ratio) in the group of ... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2504693 Thu, 30 Apr 2009 23:00:00 +0100 2504693 http://www.medworm.com/index.php?rid=2504691&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000295%2Fabstract%3Frss%3Dyes Summary: The mainstay treatments for head and neck carcinomas are surgery, radiotherapy and chemotherapy. These treatment options may be associated with considerable complications. Radical radiotherapy and chemotherapy can generally be employed only once, which presents difficulties in cases of recurrent disease or second primaries within the irradiated field. Salvage surgery at the same site is often difficult, due to progressive tissue loss. In this respect photodynamic therapy (PDT) seems to be a good alternative treatment option for small, localized tumors; with a good outcome and with excellent functional and cosmetic results. Selected patients with advanced cancer of the head and neck, who have exhausted other treatment options, can also achieve improvement in quality of life with PD... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2504691 Thu, 30 Apr 2009 23:00:00 +0100 2504691 http://www.medworm.com/index.php?rid=2504690&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000301%2Fabstract%3Frss%3Dyes In contrast to most noncutaneous cancers, achievement of local control in head and neck squamous cell carcinoma translates directly to survival. Consequently, any intervention that improves local control for tumors of the head and neck should improve survival. On the surface, this would explain the radical approach of cutting or irradiating head and neck tumors. Ultimately, these treatments have proven to achieve high rates of local control, but at times with significant and permanent disfigurement and disability. It would seem then that a minimally invasive local therapy such as PDT would be an ideal substitute. Why then are most men and women diagnosed with primary head and neck tumors still treated with surgery, radiation, and/or chemotherapy, while a minority is treated with PDT? It is... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2504690 Thu, 30 Apr 2009 23:00:00 +0100 2504690 http://www.medworm.com/index.php?rid=2504698&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000283%2Fabstract%3Frss%3Dyes In this study, we have tested the efficiency of ZnPc(OCH3)4 liposomal formulation on mice. Biodistribution studies were performed in tumor-free mice and tumor-bearing mice at various time points up to 24h after ZnPc(OCH3)4-PDT treatment. The tumor sizes were evaluated over different period in parallel experiments. The maximal efficiency and selectivity of photosensitizer accumulation in tumor tissue take place at 24h after drug administration of 0.2mg/kg bw ZnPc(OCH3)4. In the tumor sections for biochemical studies, apoptosis was visualized by activation of caspase-3. ZnPc(OCH3)4-PDT tumors showed a significant delay in growth as compared to untreated control mice. In all cases, ZnPc(OCH3)4-PDT-treated tumors showed a significant regression. The results indicated a dramatic decrease of tum... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2504698 Tue, 14 Apr 2009 23:00:00 +0100 2504698 http://www.medworm.com/index.php?rid=2504692&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000271%2Fabstract%3Frss%3Dyes Conclusions: This study demonstrated that treatment of endometrial cancer cells with both 5-ALA and hypericin followed by illumination with white light induced a significantly higher phototoxicity as revealed by colony formation. This setting which generated an in vitro effect similar to the patient's situation, might be applied in the future as an affordable and effective photodynamic therapy (PDT) modality. (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2504692 Mon, 16 Mar 2009 00:00:00 +0100 2504692 http://www.medworm.com/index.php?rid=2504689&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000374%2Fabstract%3Frss%3Dyes (Source: Photodiagnosis and Photodynamic Therapy) Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2504689 Sun, 01 Mar 2009 00:00:00 +0100 2504689 http://www.medworm.com/index.php?rid=2504696&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000052%2Fabstract%3Frss%3Dyes Summary: The aim of this study was to determine binding affinities of the Peripheral benzodiazepine receptor (PBR) with protoporphyrin IX, haematoporphyrin (Hp), and two arginized derivatives: Hp(Arg)2 and PP(Arg)2. The quenching of protein fluorescence was used to measure association constants during titration of PBR solution with PP derivatives in a function of concentration. The experimental data was fitted to theoretical curves, assuming strong and weak binding model with one binding site. As a result of this early study affinity constants were determined. The highest affinity toward PBR showed PPIX and Hp, Hp(Arg)2, PP(Arg)2 lower, respectively. Changes in pH of protein solution resulted in decrease of association constants in nearly all examined derivatives. (Source: Photodiagnosis a... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2504696 Thu, 26 Feb 2009 00:00:00 +0100 2504696 http://www.medworm.com/index.php?rid=2504697&cid=s_38630_72_f&fid=38630&url=http%3A%2F%2Fwww.pdpdt-journal.com%2Farticle%2FPIIS1572100009000040%2Fabstract%3Frss%3Dyes Summary: Photodynamic inactivation (PDI) of Escherichia coli has been studied in cultures treated with zinc(II) 2,9,16,23-tetrakis[4-(N-methylpyridyloxy)]phthalocyanine (ZnPPc+4) to obtain insight about the mechanism of damage. This phthalocyanine is rapidly bound to cells, reaching a value of ∼0.8nmol/106 cells when the cultures were incubated with 2μM sensitizer. After 30min of irradiation, a 4log decrease of E. coli survival was observed. The photocytotoxic action was investigated in plasmid and genomic DNA by electrophoretic analysis. Absorption spectroscopic studies showed that this cationic phthalocyanine interacts strongly with DNA (KDNA=4.7×106M−1). Photocleavage of calf thymus DNA sensitized by ZnPPc+4 was not found even after long irradiation periods. Similar results were a... Photodiagnosis and Photodynamic Therapy journals http://www.medworm.com/rss/comments.php?id=2504697 Mon, 09 Feb 2009 00:00:00 +0100 2504697