MedWorm.com provides a medical RSS filtering service. Over 6000 RSS medical sources are combined and output via different filters. This feed contains the latest items from the 'Phytomedicine' source. Wed, 08 Feb 2012 14:04:29 +0100 http://www.medworm.com/index.php?rid=5505552&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100571X%2Fabstract%3Frss%3Dyes (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505552 Fri, 16 Dec 2011 06:58:20 +0100 5505552 http://www.medworm.com/index.php?rid=5505565&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311005320%2Fabstract%3Frss%3Dyes The second revision of Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals gives an update of the most useful and commonly encountered phytomedicinals today. Originally authored by Professor Varro E. Tyler, Dr. Dennis V.C. Awang becomes the curator of this book. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505565 Thu, 08 Dec 2011 05:00:00 +0100 5505565 http://www.medworm.com/index.php?rid=5476973&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311005447%2Fabstract%3Frss%3Dyes (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476973 Wed, 07 Dec 2011 07:04:58 +0100 5476973 http://www.medworm.com/index.php?rid=5476979&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100225X%2Fabstract%3Frss%3Dyes In this study insulin secretion was measured in MIN6 β-cells incubated with an ethanol extract, saponin-rich fraction, and five purified saponins and cucurbitane triterpenoids from M. charantia, 3β,7β,25-trihydroxycucurbita-5,23(E)-dien-19-al (1), momordicine I (2), momordicine II (3), 3-hydroxycucurbita-5,24-dien-19-al-7,23-di-O-β-glucopyranoside (4), and kuguaglycoside G (5). Treatments were compared to incubation with high glucose (27mM) and the insulin secretagogue, glipizide (50μM). At 125μg/ml, an LC–ToF-MS characterized saponin-rich fraction stimulated insulin secretion significantly more than the DMSO vehicle, p=0.02. At concentrations 10 and 25μg/ml, compounds 3 and 5 also significantly stimulated insulin secretion as compared to the vehicle, p≤0.007, and p=0.002, respe... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476979 Fri, 02 Dec 2011 05:00:00 +0100 5476979 http://www.medworm.com/index.php?rid=5505557&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311003229%2Fabstract%3Frss%3Dyes This study was to determine whether the crude polysaccharides isolated from the roots of Bupleurum chinense DC (BCPs) attenuated lipopolysaccharide (LPS)-induced acute lung injury in mice. Mice were challenged with LPS intratracheally 2h before BCPs (20, 40 and 80mg/kg) administration. The bronchoalveolar lavage fluid (BALF) was collected 24h after LPS challenge. Treatment with BCPs reduced lung wet-to-dry weight ratio. The elevated number of total cells and protein concentration in BALF was reduced. The increased level of myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α) in BALF, and serum nitric oxide (NO) were also inhibited. BCPs significantly attenuated lung injury with improved lung morphology and reduced complement deposition. These results suggested that the effect of BCPs a... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505557 Thu, 24 Nov 2011 05:00:00 +0100 5505557 http://www.medworm.com/index.php?rid=5476984&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311005022%2Fabstract%3Frss%3Dyes Abstract: Skin aging involves degradation of extracellular matrix (ECM) in both the epidermal and dermal layers, it leaves visible signs on the surface of skin and the physical properties of the skin are modified. Chronological aging is due to passage of time, whereas premature aging occurred due to some environmental factors on skin produces visible signs such as irregular dryness, dark/light pigmentation, sallowness, severe atrophy, telangiectases, premalignant lesions, laxity, leathery appearance and deep wrinkling. There are several synthetic skincare cosmetics existing in the market to treat premature aging and the most common adverse reactions of those include allergic contact dermatitis, irritant contact dermatitis, phototoxic and photo-allergic reactions. Recent trends in anti-agin... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476984 Thu, 24 Nov 2011 05:00:00 +0100 5476984 http://www.medworm.com/index.php?rid=5476974&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311005095%2Fabstract%3Frss%3Dyes Graphical abstract: Abstract: Sinupret®, a herbal medicinal product made from Gentian root, Primula flower, Elder flower, Sorrel herb, and Verbena herb is frequently used in the treatment of acute and chronic rhinosinusitis and respiratory viral infections such as common cold. To date little is known about its potential antiviral activity. Therefore experiments have been performed to measure the antiviral activity of Sinupret® oral drops (hereinafter referred to as “oral drops”) and Sinupret® dry extract (hereinafter referred to as “dry extract”), in vitro against a broad panel of both enveloped and non-enveloped human pathogenic RNA and DNA viruses known to cause infections of the upper respiratory tract: influenza A, Chile 1/83 (H1N1) virus (FluA), Porcine Influenza A/Californ... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476974 Thu, 24 Nov 2011 05:00:00 +0100 5476974 http://www.medworm.com/index.php?rid=5387811&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311005113%2Fabstract%3Frss%3Dyes (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387811 Thu, 10 Nov 2011 08:07:32 +0100 5387811 http://www.medworm.com/index.php?rid=5387827&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311004624%2Fabstract%3Frss%3Dyes There is no doubt: Traditional Chinese Medicine (TCM) is like a silent crossborder commuter in advance through Europe, with preference in Germany. Two decades ago a special TCM-clinic had been opened in Bad Kötzting spa/Germany. Embedded in the 20th anniversary of this hospital is the publication of modern styled monographs of medicinal plants used also in TCM. Edited by well known scientists with a high reputation in the field gives proof that the books will be a treasure trove. With a remarkable openess scientific relevant question like influences of drug processing and nomenclature are addressed and ways of solution of problems shown. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387827 Wed, 26 Oct 2011 04:00:00 +0100 5387827 http://www.medworm.com/index.php?rid=5476987&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100242X%2Fabstract%3Frss%3Dyes Abstract: Yerba maté (mate) tea, a herbal tea prepared from the leaves of Ilex paraguariensis, is widely consumed in southern Latin America, and is gaining popularity worldwide. We investigated effects of an aqueous extract of mate on metabolic syndrome features in a metabolic syndrome model Tsumura Suzuki obese diabetic (TSOD) mouse. Oral administration of mate (100mg/kg) for 7 weeks induced significant decreases in body weight, body mass index, and food intake in TSOD. It significantly decreased the hyperglycemia by reducing fasting blood glucose level, and increasing glucose uptake in glucose tolerance test. It also showed significant improvement in insulin sensitivity by increasing glucose uptake in insulin tolerance test, increasing quantitative insulin sensitivity check index, and d... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476987 Mon, 24 Oct 2011 04:00:00 +0100 5476987 http://www.medworm.com/index.php?rid=5387817&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311003308%2Fabstract%3Frss%3Dyes Abstract: Treatment and control of malaria have become more difficult with the spread of drug-resistant parasites and insecticide-resistant mosquito vectors. In the search for new antimalarial drugs, ethnopharmacological sources should merit more attention. Establishing the safety of traditional herbal medicines, along with identifying their active principles, are essential steps in the production of a properly standardized and accessible herbal medicine. Phytochemical characterization could also serve as a base for the development of new chemical compounds.The genus of Ajuga belongs to the family Lamiaceae and contains at least 301 species. Many of these plants have been used in traditional medicine. Ajuga remota in particular is traditionally used as a herbal remedy for fever and infecti... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387817 Thu, 20 Oct 2011 04:00:00 +0100 5387817 http://www.medworm.com/index.php?rid=5387816&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311004570%2Fabstract%3Frss%3Dyes Abstract: Rooibos, a unique South African herbal tea, is known to be an important source of unique polyphenolic compounds. In the present study we have quantified the main polyphenolic compounds in both fermented/traditional and unfermented/“green” rooibos (Aspalathus linearis) and evaluated its cardioprotective effects against ischaemia/reperfusion injury. Male Wistar rats consumed aqueous rooibos and green tea (Camellia sinensis) extracts (2%, w/v) for 7weeks before their hearts were rapidly excised and perfused in a working heart perfusion apparatus. The results showed that the rooibos supplemented hearts significantly improved aortic output recovery after reperfusion when compared to the green tea supplemented hearts. Additionally, we showed that the rooibos extracts, containing th... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387816 Mon, 10 Oct 2011 04:00:00 +0100 5387816 http://www.medworm.com/index.php?rid=5297364&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311004752%2Fabstract%3Frss%3Dyes (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297364 Sun, 09 Oct 2011 06:26:38 +0100 5297364 http://www.medworm.com/index.php?rid=5387826&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311003291%2Fabstract%3Frss%3Dyes In the last two decades, Traditional Chinese Medicine (TCM) has more and more been appreciated as a rich source for novel lead structures with promise for the development of new therapies, including parasitic, inflammatory, cognitive, malignant and other diseases. The authors are highly experienced specialists, having published already a first comprehensive monograph on herbal TCM medications back in 1992. This pioneering book was received with great attention (“Chinese Drugs of Plant Origin”, Springer) because it strictly followed rational, science-based characterization of compounds and mechanisms. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387826 Fri, 07 Oct 2011 04:00:00 +0100 5387826 http://www.medworm.com/index.php?rid=5297378&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311003564%2Fabstract%3Frss%3Dyes Abstract: In phytomedicine complex extracts consisting of phenolics, monoterpenes or saponins are traditionally used. It is often impossible to attribute the biological activity of an extract to one or few compounds. As an explanation of the superior activity of extracts, a synergistic effect of combinations of active compounds has been suggested. Since lipophilic monoterpenes or saponins targeting the biomembrane usually accompany polar polyphenols in phytomedical preparations, we decided to investigate their effect as single substances and in combination to gain further insight into potential synergistic effects of herbal medicine. Combinations of the monoterpenes α-pinene, thymol and menthol with the monodesmosidic saponins digitonin, aescin, glycyrrhizic acid and Quillaja saponin demo... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297378 Tue, 04 Oct 2011 04:00:00 +0100 5297378 http://www.medworm.com/index.php?rid=5476983&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311003254%2Fabstract%3Frss%3Dyes In this study, we investigated the antifungal activity of allicin, an active compound of garlic on various isolates of C. albicans. The effect of allicin on biofilm production in C. albicans as compared to fluconazole, an antifungal drug, was investigated using the tetrazolium (XTT) reduction-dependent growth and crystal violet assays as well as scanning electron microscopy (SEM). Allicin-treated cells exhibited significant reduction in biofilm growth (p (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476983 Mon, 19 Sep 2011 04:00:00 +0100 5476983 http://www.medworm.com/index.php?rid=5476976&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002303%2Fabstract%3Frss%3Dyes Abstract: Cardiac fibroblasts play the key role in cardiac function and matrix metalloproteinases-9 (MMP-9) is a well known contributor to the development of myocardial remodeling. However, the direct regulation of MMP-9 on the function of cardiac fibroblasts and the underlying mechanism are far from elucidation.In the present research, recombinant protein encoding catalytic domain of MMP-9 (MMP-9 CD) was constructed and the function of neonatal cardiac fibroblasts was investigated by cell proliferation assay, migration assay, picrosirius red assay, multiplex cytokine assay and fibroblast phenotype detection. 200nM MMP-9 CD stimulated cardiac fibroblasts migration (169.4±22.5% versus 100±0%, p (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476976 Mon, 19 Sep 2011 04:00:00 +0100 5476976 http://www.medworm.com/index.php?rid=5505564&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311003230%2Fabstract%3Frss%3Dyes Abstract: Maslinic acid, a natural pentacyclic triterpene has been shown to inhibit growth and induce apoptosis in some tumour cell lines. We studied the molecular response of Raji cells towards maslinic acid treatment. A proteomics approach was employed to identify the target proteins. Seventeen differentially expressed proteins including those involved in DNA replication, microtubule filament assembly, nucleo-cytoplasmic trafficking, cell signaling, energy metabolism and cytoskeletal organization were identified by MALDI TOF-TOF MS. The down-regulation of stathmin, Ran GTPase activating protein-1 (RanBP1), and microtubule associated protein RP/EB family member 1 (EB1) were confirmed by Western blotting. The study of the effect of maslinic acid on Raji cell cycle regulation showed that it... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505564 Wed, 07 Sep 2011 04:00:00 +0100 5505564 http://www.medworm.com/index.php?rid=5505562&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002686%2Fabstract%3Frss%3Dyes This study investigated the effects of Danshen and its active ingredients on the protein expression and enzymatic activity of CYP1A2 in primary rat hepatocytes. The ethanolic extract of Danshen roots (containing mainly tanshinones) inhibited CYP1A2-catalyzed phenacetin O-deethylation (IC50=24.6μg/ml) in primary rat hepatocytes while the water extract containing mainly salvianolic acid B and danshenshu had no effect. Individual tanshinones such as cryptotanshinone, dihydrotanshinone, tanshinone IIA inhibited the CYP1A2-mediated metabolism with IC50 values at 12.9, 17.4 and 31.9μM, respectively. After 4-day treatment of the rat hepatocytes, the ethanolic extract of Danshen and tanshinone I increased rat CYP1A2 activity by 6.8- and 5.2-fold, respectively, with a concomitant up-regulation of... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505562 Wed, 07 Sep 2011 04:00:00 +0100 5505562 http://www.medworm.com/index.php?rid=5505558&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002601%2Fabstract%3Frss%3Dyes Abstract: Bioactive compounds from the medicinal plant, Eurycoma longifolia Jack have been shown to promote anti-proliferative effects on various cancer cell lines. Here we examined the effects of purified eurycomanone, a quassinoid found in Eurycoma longifolia Jack extract, on the expression of selected genes of the A549 lung cancer cells. Eurycomanone inhibited A549 lung cancer cell proliferation in a dose-dependent manner at concentrations ranging from 5 to 20μg/ml. The concentration that inhibited 50% of cell growth (GI50) was 5.1μg/ml. The anti-proliferative effects were not fully reversible following the removal of eurycomanone, in which 30% of cell inhibition still remained (p25% (p (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505558 Wed, 07 Sep 2011 04:00:00 +0100 5505558 http://www.medworm.com/index.php?rid=5505556&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002674%2Fabstract%3Frss%3Dyes In this study, we investigated the anti-inflammatory properties of modified Wu-Zi-Yan-Zong prescription (MWP), a traditional Chinese polyherbal formula, in primary cultured rat astrocytes treated with lipopolysaccharide (LPS). The results showed that MWP significantly inhibited release of nitric oxide (NO) and prostaglandin E (PGE), as well as expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 in LPS-induced rat astrocytes. Mechanism study indicated that MWP significantly inhibited nuclear factor-kappa B (NF-κB) inflammatory signaling pathway through attenuating inhibitor of nuclear factor-κB (IκB) degradation and down-regulating IκB kinases (IKKs) phosphorylation level. Moreover, MWP also decreased c-Jun NH2-terminal kinase (JNK)/p38 mitogen-activated pro... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505556 Wed, 07 Sep 2011 04:00:00 +0100 5505556 http://www.medworm.com/index.php?rid=5505554&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002650%2Fabstract%3Frss%3Dyes Abstract: Methanolic extracts of six Saudi plants were screened for their in vitro antiviral activity using influenza virus A/PR/8/34 (H1N1) and MDCK cells in an MTT assay. The results indicated that the extracts of Adeniumobesum and Tephorosianubica possessed antiviral activity (99.3 and 93.3% inhibition at the concentration of 10μg/ml, respectively). Based on these results A. obesum was selected for further study by applying bioactivity-guided fractionation to isolate its antiviral principle. The antiviral principle was isolated from the chloroform fraction through solvent fractionation, combined open liquid chromatography and HPLC. The isolated active compound A was identified as oleandrigenin-β-d-glucosyl (1→4)-β-d-digitalose, on the basis of its spectral analysis (MS, 1D and 2D N... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505554 Wed, 07 Sep 2011 04:00:00 +0100 5505554 http://www.medworm.com/index.php?rid=5505553&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002613%2Fabstract%3Frss%3Dyes In conclusion, DG treatment activated both ERK/Nrf2 and PKCɛ pathways, presumably by ROS arising from CYP-catalyzed processes, with resultant inhibition of hypoxia/reoxygenation-induced apoptosis immediately after DG treatment or even after an extended time interval following DG treatment. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505553 Wed, 07 Sep 2011 04:00:00 +0100 5505553 http://www.medworm.com/index.php?rid=5476982&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002662%2Fabstract%3Frss%3Dyes This study was aimed to evaluate effects of certain essential oils namely Cinnamomum verum, Syzygium aromaticum, Cymbopogon citratus, Cymbopogon martini and their major components cinnamaldehyde, eugenol, citral and geraniol respectively, on growth, hyphal ultrastructure and virulence factors of Aspergillus fumigatus and Trichophyton rubrum. The antifungal activity of essential oils and their major constituents was in the order of cinnamaldehyde>eugenol>geraniol=C. verum>citral>S. aromaticum>C. citratus>C. martini, both in liquid and solid media against T. rubrum and A. fumigatus. Based on promising antifungal activity of eugenol and cinnamaldehyde, these oils were further tested for their inhibitory activity against ungerminated and germinated conidia in test fungi. Cinnamaldehyde was fou... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476982 Wed, 07 Sep 2011 04:00:00 +0100 5476982 http://www.medworm.com/index.php?rid=5476977&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311003242%2Fabstract%3Frss%3Dyes Conclusion: WS® 1442 activates rbcNOS and causes NO-formation in RBCs. WS® 1442-dependent NO-formation however does not affect RBC-deformability at normoxia. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476977 Wed, 07 Sep 2011 04:00:00 +0100 5476977 http://www.medworm.com/index.php?rid=5196681&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100345X%2Fabstract%3Frss%3Dyes (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196681 Wed, 07 Sep 2011 00:32:16 +0100 5196681 http://www.medworm.com/index.php?rid=5476980&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002649%2Fabstract%3Frss%3Dyes Abstract: The antidiabetic activities of the aqueous (AqEx) and ethanolic (AlEx) extracts of Cleome droserifolia (Forssk.) Del., were tested in cultured C2C12 skeletal muscle cells and 3T3-L1 adipocytes. An 18-h treatment with the AqEx increased basal glucose uptake by 33% [insulin equivalent (IE)=1.3±0.04] in muscle cells comparable to a 25.5% increase caused by 100nM insulin (IE=1±0.03). Fractionation of the tested AqEx yielded hexane (HxFr), chloroform (ClFr) and ethyl acetate (EtFr) fractions which exerted 38, 52 and 35% increase in the glucose uptake corresponding to an IE of 1.5±0.06, 2.0±0.04 and 1.4±0.04, respectively. Only the ClFr and EtFr accelerated the triglyceride accumulation [rosiglitazone equivalent (RE) was 0.9±0.13 and 0.63±0.12, respectively] in pre-adipocytes un... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476980 Mon, 05 Sep 2011 04:00:00 +0100 5476980 http://www.medworm.com/index.php?rid=5297366&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100198X%2Fabstract%3Frss%3Dyes Conclusion: These data indicate that American ginseng prevented glucose-induced damage in the HUVECs through its antioxidant properties. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297366 Tue, 16 Aug 2011 04:00:00 +0100 5297366 http://www.medworm.com/index.php?rid=5144416&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002534%2Fabstract%3Frss%3Dyes (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144416 Sun, 14 Aug 2011 23:00:00 +0100 5144416 http://www.medworm.com/index.php?rid=5196685&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002418%2Fabstract%3Frss%3Dyes Abstract: Type 1-diabetes is an autoimmune disease, where a chronic inflammatory process finally causes β-cell death and insulin deficiency. Extracts from gum resin of Boswellia serrata (BE) have been shown to posses anti-inflammatory properties especially by targeting factors/mediators related to autoimmune diseases. Multiple low dose-streptozotocin (MLD-STZ) treatment is a method to induce diabetes in animals similar to Type 1 diabetes in humans.It was aimed to study whether or not a BE could prevent hyperglycemia, inflammation of pancreatic islets and increase of proinflammatory cytokines in the blood in MLD-STZ treated mice.In BK+/+ wild type mice, 5days of daily treatment with 40mg/kg STZ i.p. produced permanent increase of blood glucose, infiltration of lymphocytes into pancreatic i... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196685 Wed, 10 Aug 2011 23:00:00 +0100 5196685 http://www.medworm.com/index.php?rid=5144424&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001930%2Fabstract%3Frss%3Dyes Abstract: Artemisia annua L. (sweet wormwood, qinhao) has traditionally been used in Chinese medicine. The isolation of artemisinin from Artemisia annua and its worldwide accepted application in malaria therapy is one of the showcase success stories of phytomedicine during the past decades. Artemisinin-type compounds are also active towards other protozoal or viral diseases as well as cancer cells in vitro and in vivo. Nowadays, Artemisia annua tea is used as a self-reliant treatment in developing countries. The unsupervised use of Artemisia annua tea has been criticized to foster the development of artemisinin resistance in malaria and cancer due to insufficient artemisinin amounts in the plant as compared to standardized tablets with isolated artemisinin or semisynthetic artemisinin deri... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144424 Tue, 09 Aug 2011 23:00:00 +0100 5144424 http://www.medworm.com/index.php?rid=5196694&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002406%2Fabstract%3Frss%3Dyes As an umbrella organisation of national phytotherapy or herbal medicine associations ESCOP has aimed to advance the scientific status of herbal medicinal products and to assist with the harmonisation of their regulatory status at the European level for more than 20years. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196694 Sun, 07 Aug 2011 23:00:00 +0100 5196694 http://www.medworm.com/index.php?rid=5505563&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002261%2Fabstract%3Frss%3Dyes In this study we examined whether GBE induced spontaneous bleeding or accelerated warfarin anticoagulation via herb–drug interaction. Mice were given GBE or various active components of GBE orally for 5 days and blood coagulation parameters and hepatic cytochrome P450 enzymes (CYPs) were measured. Mice also received warfarin (racemate, (S)- or (R)-enantiomer) for the last 3 days of the 5-day regimen to examine GBE–warfarin interactions. Neither GBE (up to 1000mg/kg) nor ginkgolide B (up to 140mg/kg), a platelet-activating factor antagonist, influenced blood coagulation parameters. In contrast, GBE attenuated the anticoagulant action of warfarin. Bilobalide, a component of GBE that markedly induced hepatic CYPs including (S)-warfarin hydroxylase, showed similar effects. For (S)-warfarin... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505563 Mon, 01 Aug 2011 04:00:00 +0100 5505563 http://www.medworm.com/index.php?rid=5505561&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002339%2Fabstract%3Frss%3Dyes Graphical abstract: The combination of mechanochemical activation and spray congealing produces a delivery system with enhanced oral bioavailability of main flavolignans of Silybum Marianum dry extract, Silybin A and B.Abstract: The aim of the work was to produce a delivery system for Silybum Marianum dry extract with enhanced oral bioavailability by combining two technologies (mechanochemical activation and spray congealing). Initially, the active was coground with sodium croscarmellose in a planetary mill in order to reach an activated state more prone to dissolution. DSC, XRD, FT-IR and LD analyses showed the formation of nanosized particles of dry extract, with reduced degree of crystallinity of the main crystalline flavolignans (silybine A and B). Then, microparticles containing the a... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505561 Mon, 01 Aug 2011 04:00:00 +0100 5505561 http://www.medworm.com/index.php?rid=5505559&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002352%2Fabstract%3Frss%3Dyes Graphical abstract: We studied the possible cellular mechanisms of hyperoside isolated from Apocynum venetum leaves in corticosterone-induced neurotoxicity, using PC12 cells as a suitable in vitro model of depression. Cell viability was quantitated by 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. The release amount of lactic dehydrogenase (LDH) and intracellular Ca2+ concentration were measured using kit, and transcript abundances of brain-derived neurotrophic factor (BDNF) and cAMP response element binding protein (CREB) were determined by real-time RT-PCR.Abstract: In the present work, we studied the possible cellular mechanisms of hyperoside isolated from Apocynum venetum leaves in corticosterone-induced neurotoxicity, using PC12 cells as a suitable in vitro... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505559 Mon, 01 Aug 2011 04:00:00 +0100 5505559 http://www.medworm.com/index.php?rid=5505555&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002364%2Fabstract%3Frss%3Dyes Abstract: Aqueous extract of Kalanchoe pinnata (Kp) have been found effective in models to reduce acute anaphylactic reactions. In the present study, we investigate the effect of Kp and the flavonoid quercetin (QE) and quercitrin (QI) on mast cell activation in vitro and in a model of allergic airway disease in vivo. Treatment with Kp and QE in vitro inhibited degranulation and cytokine production of bone marrow-derived mast cells following IgE/FcɛRI crosslinking, whereas treatment with QI had no effect. Similarly, in vivo treatment with Kp and QE decreased development of airway hyperresponsiveness, airway inflammation, goblet cell metaplasia and production of IL-5, IL-13 and TNF. In contrast, treatment with QI had no effect on these parameters. These findings demonstrate that treatment w... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505555 Mon, 01 Aug 2011 04:00:00 +0100 5505555 http://www.medworm.com/index.php?rid=5476986&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002376%2Fabstract%3Frss%3Dyes Abstract: Over-expression of P-gp, MRP1 and BCRP in tumor cells is one of the important mechanisms leading to multidrug resistance (MDR), which impairs the efficacy of chemotherapy. P-gp, MRP1 and BCRP are ABC (ATP-Binding Cassette) transporters, which can expel a variety of lipophilic anti-cancer drugs and protect tumor cells. During a screening of MDR reversal agents among alkaloids of various structural types, a piperidine alkaloid, piperine (a main piperidine alkaloid in Piper nigurm) was identified as an inhibitor. Piperine can potentiate the cytotoxicity of anti-cancer drugs in resistant sublines, such as MCF-7/DOX and A-549/DDP, which were derived from MCF-7 and A-549 cell lines. At a concentration of 50μM piperine could reverse the resistance to doxorubicin 32.16 and 14.14 folds, ... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476986 Mon, 01 Aug 2011 04:00:00 +0100 5476986 http://www.medworm.com/index.php?rid=5476985&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002388%2Fabstract%3Frss%3Dyes Abstract: Aims: The use of preparations from Bryophyllum pinnatum (Lamarck) Oken (Kalanchoe pinnata (Lamarck) Persoon) in tocolysis is supported by clinical evidence. We studied here the effect of B. pinnatum leaf press juice and its chemical fractions on the response of human myometrial strips. No data are available if the influence on myometrial strips of the juice differs from that of its components in the chemical fractions, in order to increase the pharmacological effect.Methodology: In vitro study to test the effect of repeated addition of B. pinnatum leaf press juice (BPJ) and its chemical components in several dilutions (undiluted, 1–10%) on myometrium strips hang up in a myograph chamber. Chemical analysis is including HPLC, MPLC with Sephadex LH-20 and TLC.Results: All test sol... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476985 Mon, 01 Aug 2011 04:00:00 +0100 5476985 http://www.medworm.com/index.php?rid=5476978&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002315%2Fabstract%3Frss%3Dyes Abstract: White tea (WT) is very similar to green tea (GT) but it is exceptionally prepared only from the buds and young tea leaves of Camelia sinensis plant while GT is prepared from the matured tea leaves. The present study was investigated to examine the effects of a 0.5% aqueous extract of WT in a streptozotocin-induced diabetes model of rats. Six-week-old male Sprague-Dawley rats were divided into 3 groups of 6 animals in each group namely: normal control (NC), diabetic control (DBC) and diabetic white tea (DWT). Diabetes was induced by an intraperitoneal injection of streptozotocin (65mg/kgBW) in DBC and DWT groups except the NC group. After 4 weeks feeding of 0.5% aqueous extracts of WT, the drink intake was significantly (P (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476978 Mon, 01 Aug 2011 04:00:00 +0100 5476978 http://www.medworm.com/index.php?rid=5387825&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001929%2Fabstract%3Frss%3Dyes Abstract: Ramalin (γ-glutamyl-N′-(2-hydroxyphenyl)hydrazide), a novel compound, was isolated from the methanol–water extract of the Antarctic lichen Ramalina terebrata by several chromatographic methods. The molecular structure of ramalin was determined by spectroscopic analysis. The experimental data showed that ramalin was five times more potent than commercial butylated hydroxyanisole (BHA) in scavenging 1-diphenyl-2-picryl-hydazil (DPPH) free radicals, 27 times more potent in scavenging 2,2′-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid free radicals (ABTS+) than the vitamin E analogue, trolox, and 2.5 times more potent than BHT in reducing Fe3+ to Fe2+ ions. Similarly, ramalin was 1.2 times more potent than ascorbic acid in scavenging superoxide radicals and 1.25 times more ... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387825 Mon, 01 Aug 2011 04:00:00 +0100 5387825 http://www.medworm.com/index.php?rid=5387822&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001954%2Fabstract%3Frss%3Dyes Abstract: The effect of aqueous extract from R. rosea root on lifespan and the activity of antioxidant enzymes in budding yeast Saccharomyces cerevisiae have been studied. The supplementation of the growth medium with R. rosea extract decreased survival of exponentially growing S. cerevisiae cells under H2O2-induced oxidative stress, but increased viability and reproduction success of yeast cells in stationary phase. The extract did not significantly affect catalase activity and decreased SOD activity in chronologically aged yeast population. These results suggest that R. rosea acts as a stressor for S. cerevisiae cells, what sensitizes yeast cells to oxidative stress at exponential phase, but induces adaptation in stationary phase cells demonstrating the positive effect on yeast survival ... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387822 Mon, 01 Aug 2011 04:00:00 +0100 5387822 http://www.medworm.com/index.php?rid=5387819&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002340%2Fabstract%3Frss%3Dyes Abstract: Citrus fruits are the major source of flavonoids for humans, and flavanones are the main flavonoids in the Citrus species. Among the Citrus flavanones, the glycoside derivatives of naringenin, naringin and narirutin, are the most abundant in grapefruit. The present study aimed to investigate the molecular events of melanogenesis induced by naringenin in murine B16-F10 melanoma cells. Melanin content, tyrosinase activity and Western blot analysis were performed to elucidate the possible underlying mechanisms. Exposure of melanoma cells to naringenin resulted in morphological changes accompanied by the induction of melanocyte differentiation-related markers, such as melanin synthesis, tyrosinase activity, and the expression of tyrosinase and microphthalmia-associated transcription ... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387819 Mon, 01 Aug 2011 04:00:00 +0100 5387819 http://www.medworm.com/index.php?rid=5387814&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002327%2Fabstract%3Frss%3Dyes Abstract: Concurrent use of herbal medicine (HM) and conventional medicine (CM) is increasing. However, little is known about the prevalence of drug-induced liver injury (DILI) related to this concurrent use. In order to investigate changes in liver enzymes during concurrent use of HM and CM and to assess the prevalence of DILI related to their concurrent use, we screened for liver injury among inpatients at our institution who were administered both HM and CM for at least 14 days while hospitalized between 2006 and 2010. We used the Council for International Organization of Medical Science (CIOMS) laboratory criteria to define liver injury. Of the 892 patients included in the study, 34 (3.81%) had liver injury on admission and 21 (2.35%) had liver injury at discharge. Of the 48 cases that... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387814 Mon, 01 Aug 2011 04:00:00 +0100 5387814 http://www.medworm.com/index.php?rid=5387813&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002273%2Fabstract%3Frss%3Dyes Discussion: EGb 761 (240mg once daily) improves free recall of appointments in middle-aged healthy volunteers, which requires high demands on self-initiated retrieval of learned material. This function is known to be sensitive to normal aging, i.e., reduced in healthy middle-aged subjects. No effects are seen in a less demanding everyday memory task which does not tap this critical function. This ties in with previous studies which found specific patterns of benefit from EGb 761 in demanding cognitive tasks. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387813 Mon, 01 Aug 2011 04:00:00 +0100 5387813 http://www.medworm.com/index.php?rid=5387812&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002017%2Fabstract%3Frss%3Dyes Conclusions: Treatment with a geranial plus carvenone chemotype of L. alba hydro-alcoholic extract is a cheap, widely available, highly effective therapy to reduce both the intensity and the frequency of headache episodes of migraine patients with no side effects. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387812 Mon, 01 Aug 2011 04:00:00 +0100 5387812 http://www.medworm.com/index.php?rid=5297365&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001991%2Fabstract%3Frss%3Dyes Abstract: Ivy leaves extracts are authorised in medicinal products for the treatment of acute bronchitis. Different studies and the long experience on the market show safety and efficacy of this drug. A double-blind, randomised study was conducted to assess the efficacy and tolerability of ivy leaves soft extract with an other ivy leaves extract. 590 patients with acute bronchitis participated in this study. They were treated with test or comparator for 7 days (±1). The Bronchitis Severity Score (BSS) decreased gradually and to a similar extent from Day 1 to Day 7 in both treatment groups. Starting from values of 6.2–6.3±1.2, the BSS decreased by approximately 4.7–4.9 points until Day 7, so that patients left the study with a mean BSS of 1.4–1.6. The BSS subscales cough, sputum, rh... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297365 Mon, 01 Aug 2011 04:00:00 +0100 5297365 http://www.medworm.com/index.php?rid=5144417&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001917%2Fabstract%3Frss%3Dyes Conclusion: There is limited evidence that regular consumption of GT in amounts of at least 0.6–1.5l/day may increase AC and reduce lipid peroxidation (especially oxidation of LDL). This may contribute to the protection against CVDs and different types of cancer. Beneficial effects seem to be more likely in participants exposed to oxidative challenge. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144417 Sun, 31 Jul 2011 23:00:00 +0100 5144417 http://www.medworm.com/index.php?rid=5387824&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001966%2Fabstract%3Frss%3Dyes Abstract: To investigate the effect and underlying mechanism of aescin on acute liver injury induced by endotoxin, liver injury was established by injecting lipopolysaccharide (LPS) in mice. Animals were assigned to seven groups: the control group and groups treated with LPS (40mg/kg), aescin (3.6mg/kg), LPS plus dexamethasone (4mg/kg) and LPS plus aescin (0.9, 1.8 or 3.6mg/kg). Hepatic histopathological changes were examined under a light microscope. Activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum were determined. Levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), nitric oxide (NO) and antioxidative parameters in liver homogenate were measured. Glucocorticoid receptor (GR), 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387824 Fri, 29 Jul 2011 04:00:00 +0100 5387824 http://www.medworm.com/index.php?rid=5476975&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002297%2Fabstract%3Frss%3Dyes Abstract: Polydatin preconditioning (PPC) has been reported to be protective against brain and intestine ischemia/reperfusion injury (I/R injury), but whether polydatin exerts cardioprotective effect against myocardial ischemia/reperfusion and the underlying mechanisms remain unclear. Previous studies have demonstrated that oxidative stress plays an important role in the process of I/R. Elevation of oxidative agents and decline in anti-oxidant substance would promote I/R. Meanwhile, the activation of PKC signaling seems to mediate the cardioprotective effects of many drugs by alleviating Ca2+ influx. In the present study, we reported for the first time that intravenous administration of polydatin before I/R significantly limited the infarct size, creatine phosphokinase (CPK) and lactate de... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476975 Thu, 28 Jul 2011 04:00:00 +0100 5476975 http://www.medworm.com/index.php?rid=5387818&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002029%2Fabstract%3Frss%3Dyes In this study, an extract of Curcuma phaeocaulis Valeton referred as Cpv was prepared and its anti-tumor effect was evaluated with MCF-7 and MDA-MB-231 cells. Curcuma phaeocaulis Valeton power was extracted with ethanol and the main components of the extract (Cpv) were analyzed with HPLC. The effect of Cpv on MCF-7 cells proliferation, intracellular reactive oxygen species (ROS) formation, mitochondrial membrane potential (ΔΨm), apoptosis, apoptotic related proteins, MDA-MB-231 cell migration, and integrins expression were determined. Furthermore, the effect of Cpv on some key signal transduction molecules was also investigated. Furanodienone, germacrone and furanodiene were identified as the main components of Cpv. Cpv treatment significantly inhibited cell proliferation, increased LDH ... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387818 Thu, 28 Jul 2011 04:00:00 +0100 5387818 http://www.medworm.com/index.php?rid=5387823&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001942%2Fabstract%3Frss%3Dyes Abstract: Valeriana wallichii DC (Valerianaceae), popularly named as Indian valerian has been shown to exist as three chemotypes. The present study evaluated the antidepressant like effect of root essential oil of Valeriana wallichii patchouli alcohol chemotype in both acute and chronic treatment study using forced swim test (FST). Mice (n=6 per group) received 10, 20 and 40mg/kg p.o. doses of test drug. Single administration of oil significantly inhibited the immobility period (57.6% and 46.9%) at doses 20 and 40mg/kg respectively without changing the motor function (p (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387823 Wed, 27 Jul 2011 04:00:00 +0100 5387823 http://www.medworm.com/index.php?rid=5476981&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100239X%2Fabstract%3Frss%3Dyes This study describes the antifungal activity of coriander essential oil on Candida spp., which could be useful in designing new formulations for candidosis treatment. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5476981 Tue, 26 Jul 2011 04:00:00 +0100 5476981 http://www.medworm.com/index.php?rid=5387821&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002248%2Fabstract%3Frss%3Dyes In conclusion, the present results showed that the methanolic extract standardized on flavonoids content of Byrsonima crassifolia possesses potential antidepressant-like effects in the FST in mice, and could be considered as relatively safe toxicologically with no deaths of mice when orally administered at 2000mg/kg. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387821 Tue, 26 Jul 2011 04:00:00 +0100 5387821 http://www.medworm.com/index.php?rid=5387815&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002285%2Fabstract%3Frss%3Dyes Conclusions: Crataegus extract treatment effects on physiologic outcomes and typical symptoms were modulated by baseline severity. Taking baseline differences into account, benefits were comparable in male and female patients with impaired exercise-tolerance in early chronic heart-failure. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387815 Tue, 26 Jul 2011 04:00:00 +0100 5387815 http://www.medworm.com/index.php?rid=5387820&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001978%2Fabstract%3Frss%3Dyes In conclusion, eight flavonoids were identified in rat brain after administration of AMEE; meanwhile, these flavonoids might represent the potential bioactive components of AMEE and contribute to its anticonvulsant and antidepressant-like activity in vivo. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5387820 Mon, 25 Jul 2011 04:00:00 +0100 5387820 http://www.medworm.com/index.php?rid=5505560&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002005%2Fabstract%3Frss%3Dyes Abstract: Vitis amurensis (Vitaceae) has been reported to have anti-oxidant and anti-inflammatory activities. The present study investigated a methanol extract from the leaf and stem of V. amurensis for neuroprotective effects on cerebral ischemic damage in rats and on excitotoxicity induced by glutamate in cultured rat cortical neurons. Transient focal cerebral ischemia was induced by 2h middle cerebral artery occlusion followed by 24h reperfusion (MCAO/reperfusion) in rats. Orally administered V. amurensis (25–100mg/kg) reduced MCAO/reperfusion-induced infarct and edema formation, neurological deficits, and neuronal death. Depletion of glutathione (GSH) level and lipid peroxidation induced by MCAO/reperfusion was inhibited by administration of V. amurensis. The increase of phosphorylat... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5505560 Thu, 21 Jul 2011 04:00:00 +0100 5505560 http://www.medworm.com/index.php?rid=5297373&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001887%2Fabstract%3Frss%3Dyes This study demonstrates that Schisandra chinensis exhibited relaxant effects on agonist-induced contraction in guinea pig ileum, with schisandrin, schisandrol B, schisandrin A and schisandrin B being the major active ingredients. The antispasmodic action of schisandrin A involved inhibitions on both Ca2+ influx through L-type Ca2+ channels and intracellular Ca2+ mobilization, rather than specific antagonism of cholinergic muscarinic receptors. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297373 Mon, 18 Jul 2011 04:00:00 +0100 5297373 http://www.medworm.com/index.php?rid=5297375&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001875%2Fabstract%3Frss%3Dyes This study demonstrated that PSP can competitively inhibit tolbutamide 4-hydroxylation in both pooled human liver microsomes and specific human CYP2C9 in vitro. This study compliments previous findings in the rat that PSP can inhibit human tolbutamide 4-hydroxylase, but the relatively high Ki values in human CYP2C9 would suggest a low potential for PSP to cause herb–drug interaction. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297375 Fri, 15 Jul 2011 04:00:00 +0100 5297375 http://www.medworm.com/index.php?rid=5297374&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001863%2Fabstract%3Frss%3Dyes Abstract: According to Indian Systems of Medicine, Spilanthes acmella (L.) Murr. (Family – Asteraceae), is considered effective in the treatment of sexual deficiencies especially due to ageing. In the present study, characterization of ethanolic extracts of the Spilanthes acmella flower and its effect on general mating pattern, penile erection and serum hormone levels of normal male Wistar albino rats were investigated and compared with sildenafil citrate. In vitro nitric oxide release was also investigated in human corpus cavernosum cell line. As N-alkylamides are a promising group, their profiling was performed using a gradient reversed phase high performance liquid chromatography/electrospray ionization ion trap mass spectrometry (HPLC/ESI-MS) method on an embedded polar column. MS1 a... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297374 Fri, 15 Jul 2011 04:00:00 +0100 5297374 http://www.medworm.com/index.php?rid=5297371&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001899%2Fabstract%3Frss%3Dyes In this study, we investigated the effects of schisandra lignans extract (SLE) on anxiety disorder in restraint-stressed mice using light–dark (L–D) test. The influences of restraint stress on the levels of monoamines: noradrenaline (NE), dopamine (DA) and serotonin (5-HT) in cerebral cortex, as well as plasma corticosterone (CORT) were studied in mice. The HPLC fingerprint of SLE was recorded and the percentage composition of Schisandra lignans was determined as 82.63%. In L–D test, it was found out that 18h of restraint stress significantly decreased the anxiolytic parameters (explorative behaviors, e.g. number of entries, time spent) in light area indicating high state of anxiety in stressed mice. In addition, restraint stress elevated NE, DA, and 5-HT levels in cerebral cortex of... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297371 Fri, 15 Jul 2011 04:00:00 +0100 5297371 http://www.medworm.com/index.php?rid=5297370&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100184X%2Fabstract%3Frss%3Dyes In this study, the possible neuroprotective effect of standardized dry olive leaf extract (OLE) is investigated for the first time. Transient global cerebral ischemia in Mongolian gerbils was used to investigate the OLE effects on different parameters of oxidative stress and neuronal damage in hippocampus. The biochemical measurements took place at different time points (80min, 2, 4 and 24h) after reperfusion. The effects of applied OLE were compared with effects of quercetin, a known neuroprotective plant flavonoid. Pretreatment with OLE (100mg/kg, per os) significantly inhibited production of superoxide and nitric oxide, decreased lipid peroxidation, and increased superoxide dismutase activity in all time points examined. Furthermore, OLE offered histological improvement as seen by decre... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297370 Fri, 15 Jul 2011 04:00:00 +0100 5297370 http://www.medworm.com/index.php?rid=5196693&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001905%2Fabstract%3Frss%3Dyes In this study, we investigated whether treatment with swainsonine affects the sensitivity of Ehrlich ascites carcinoma (EAC) cells to cisplatin. To this end, male C57BL/6 mice were treated with swainsonine (SW – 0.5mg/kg, i.p., twice-daily for ten days) and/or cisplatin (Cis – 0.25mg/kg, i.p., every other day for a total of five applications) two days after transplantation with EAC cells. The results showed a greater reduction in the ascites volume in mice from the CisSW group (63.5%) than in mice from the Cis group (45.7%), an elevated induction of apoptosis by CisSW treatment when compared to Cis alone, as demonstrated by higher percentage of cells in the subG1 phase in that group (p (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196693 Thu, 14 Jul 2011 23:00:00 +0100 5196693 http://www.medworm.com/index.php?rid=5297376&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001176%2Fabstract%3Frss%3Dyes In conclusion, adenine-induced CRF in rats significantly increased BP, and this was significantly mitigated by administration of AG. Possible mechanisms of these changes and the protective effect of AG will be investigated. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297376 Fri, 08 Jul 2011 04:00:00 +0100 5297376 http://www.medworm.com/index.php?rid=5144427&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000882%2Fabstract%3Frss%3Dyes Abstract: Naringin is considered the main effective compound of Drynaria Rhizome, which is used commonly in the treatment of osteoporosis in traditional Chinese medicine. However, we found neoeriocitrin, a new compound isolated from Drynaria Rhizome, showed a better activity than naringin on proliferation and osteogenic differentiation in MC3T3-E1. Both neoeriocitrin and naringin exhibited the best effect on proliferation and osteogenic differentiation at concentration of 2μg/ml. Neoeriocitrin more significantly improved proliferation and alkaline phosphatase (ALP) activity as well as up-regulated Runx2, COLI and OCN expression by 56%, 37% and 14% respectively than naringin. Furthermore, neoeriocitrin could rescue the inhibition effect of cell differentiation induced by PD98059 to some de... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144427 Thu, 07 Jul 2011 23:00:00 +0100 5144427 http://www.medworm.com/index.php?rid=4999572&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001851%2Fabstract%3Frss%3Dyes This study examined changes in cytokine production in blood samples from 30 volunteers before and during 8-day oral administration with an ethanolic extract of fresh Echinacea purpurea (Echinaforce®). Daily blood samples were ex vivo stimulated by LPS/SEB or Zymosan and analysed for a series of cytokines and haematological and metabolic parameters. Treatment reduced the proinflammatory mediators TNF-α and IL-1β by up to 24% (p (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999572 Wed, 06 Jul 2011 14:51:16 +0100 4999572 http://www.medworm.com/index.php?rid=4999568&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311002182%2Fabstract%3Frss%3Dyes (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999568 Wed, 06 Jul 2011 14:51:15 +0100 4999568 http://www.medworm.com/index.php?rid=5196684&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001528%2Fabstract%3Frss%3Dyes Abstract: We investigated the effects of Achillea millefolium extract in vitro on the growth of primary rat vascular smooth muscle cells (VSMCs) as well as the potential involvement of estrogen receptors (ERs) in this process. In addition, the ability of A. millefolium extract to modulate the NF-κB pathway was tested in human umbilical vein endothelial cells (HUVECs). The fingerprinting of the extract was carried out by HPLC-DAD and LC–MSn and main constituents were flavonoids (10%) and dicaffeolylquinic acid derivatives (12%). The extract enhanced VSMC growth at least in part by acting through ERs and impaired NF-κB signaling in HUVECs. The various compounds may act with different mode of actions thus contributing to the final effect of the extract. Our findings support some of the tr... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196684 Sun, 19 Jun 2011 23:00:00 +0100 5196684 http://www.medworm.com/index.php?rid=5144431&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001255%2Fabstract%3Frss%3Dyes Abstract: Hyper-pigmentation of the skin is a common problem that is prevalent in middle aged and elderly people. It is caused by over production of melanin. Tyrosinase is known to be the key enzyme in melanin production. Ethanolic extract of Greyia flanaganii leaves showed significant (P (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144431 Wed, 15 Jun 2011 23:00:00 +0100 5144431 http://www.medworm.com/index.php?rid=5297372&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001504%2Fabstract%3Frss%3Dyes Conclusions: Our results suggest that administration of tetramethylpyrazine may reduce kidney damage caused by diabetes. This protective effect may be mediated, in part, by downregulated expression of vascular endothelial growth factor in the kidney. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297372 Mon, 13 Jun 2011 04:00:00 +0100 5297372 http://www.medworm.com/index.php?rid=5196692&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001553%2Fabstract%3Frss%3Dyes Abstract: Searching for agents that could be effective in the treatment of cancer, special highlight has focused on the study of numerous plant-derived compounds. We previously demonstrated that anthraquinones (AQs) isolated from a vegetal species: Heterophyllaea pustulata Hook f. (Rubiaceae), such as rubiadin, rubiadin-1-methyl ether, soranjidiol, soranjidiol-1-methyl ether exhibit photosensitizing properties without antecedents as photodynamic agents in malignant cells. In the present study, we investigated the potential role of these AQs as a phototoxic agent against human breast carcinoma using MCF-7c3 cells. All AQs exhibited significant photocytotoxicity on cancer cells at the concentration of 100μM with 1J/cm2 light dose, resulting soranjidiol-1-methyl ether in complete cell destru... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196692 Sun, 12 Jun 2011 23:00:00 +0100 5196692 http://www.medworm.com/index.php?rid=5196689&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001565%2Fabstract%3Frss%3Dyes Abstract: As part of ongoing research on the chemical composition and the antimicrobial properties of Burkinabe plants essential oils alone and in combination, essential oils (EOs) from leaves of Cymbopogon citratus and Cymbopogon giganteus from Burkina Faso were analyzed by GC–FID and GC–MS. Five constituents, which accounted for 96.3% of the oil, were identified in the EO of C. citratus. Geranial (48.1%), neral (34.6%) and myrcene (11.0%) were the major constituents. For C. giganteus a total of eight compounds were identified which represented 86.0% of the oils extracted. The dominant compounds were limonene (42%) and a set of monoterpene alcohols: trans-p-mentha-1(7),8-dien-2-ol (14.2%), cis-p-mentha-1(7),8-dien-2-ol (12%), trans-p-mentha-2,8-dien-1-ol (5.6%) and cis-p-mentha-2,8-di... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196689 Sun, 12 Jun 2011 23:00:00 +0100 5196689 http://www.medworm.com/index.php?rid=5196686&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100153X%2Fabstract%3Frss%3Dyes Graphical abstract: Isoquinoline alkaloid rich fraction (AFTC) derived from stem of TC and three alkaloids viz., palmatine, jatrorrhizine and magnoflorine were evaluated for insulin-mimicking and insulin-releasing effect in vitro and in vivo. Their effect on hepatic gluconeogenesis was examined in rat hepatocytes. Insulin releasing effect was detected in vitro using rat pancreatic β-cell line, RINm5F. Furthermore, effects of AFTC and isolated alkaloids on serum glucose and insulin level were studied in fasted and glucose challenged normal rats. AFTC significantly decreased gluconeogenesis in rat hepatocytes as insulin did and it increases insulin secretion in RINm5F cells similar to tolbutamide. In acute 30min test in vitro, AFTC, palmatine, jatrorrhizine and magnoflorine stimulated insul... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196686 Sun, 12 Jun 2011 23:00:00 +0100 5196686 http://www.medworm.com/index.php?rid=5196683&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001541%2Fabstract%3Frss%3Dyes The objective of the present study was to evaluate the cardioprotective effects of Danshensu (DSS), a water-soluble active component of Danshen, on cardiac hypertrophy in rats. We are the first to report that DSS reversed Cx43 down-regulation in ventricular tissue. Cardiomyopathy in rats was produced using isoproterenol (Iso) treatment (2.5mg/kg/d, s.c.) for seven days. DSS (3 and 10mg/kg/d, i.p.) and Valsartan (Val) (10mg/kg, i.g.) were administered on days 4–7 of Iso-treatment. Heart weight index, hemodynamic parameters, and ECG II parameters were monitored and recorded; protein expression of left ventricular connexin 43 (Cx43) and the activity of the redox system were assayed, and arrhythmias were produced using a coronary ligation/reperfusion procedure. The results demonstrated that ... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196683 Sun, 12 Jun 2011 23:00:00 +0100 5196683 http://www.medworm.com/index.php?rid=5196682&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001516%2Fabstract%3Frss%3Dyes Abstract: The aims of this study was to evaluate the effects of oil-resin of Copaiba (Copaifera duckei Dwyer), aired in vaginal cream on the reproductive performance of female rats (Rattus norvegicus). To determine the components of the C. duckei oleoresin, gas chromatography coupled with mass spectrometry (CG–MS) was used, and considering the trans-caryophyllene sesquiterpene as a phytochemical marker in the oleoresin. Due to the extensive use of copaiba oleoresin in the suppository form for gynecological infections, an evaluation was carried out on the effects of copaiba oleoresin (Copaifera duckei Dwyer), delivered in a vaginal cream, on the reproductive performance of female Wistar rats. For this purpose, three groups (n=5–6/group) of female rats were treated as follows: 1 – vagi... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196682 Sun, 12 Jun 2011 23:00:00 +0100 5196682 http://www.medworm.com/index.php?rid=5297369&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001498%2Fabstract%3Frss%3Dyes Abstract: Anti-depression effects of Danggui-Shaoyao-San (DSS, 1.8–7.2g/kg, orally), a famous Chinese compound prescription with a fixed combination, on forced swimming test (FST) and chronic unpredictable mild stress (CUMS) model were investigated. DSS (7.2g/kg, orally, 7 days) shortened immobility time in FST model and DSS (3.6 or 7.2g/kg, orally, 21 days) increased the open-field activities and the percentage of sugar preference in CUMS model. DSS (7.2g/kg, orally, 21 days) also decreased the content of arginine vasopressin (AVP) in the pituitary and the expression of AVP mRNA in hypothalamus compared with the stress control group. These results demonstrated for the first time DSS has anti-depression effect and it may be influencing the central AVP system. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297369 Fri, 10 Jun 2011 04:00:00 +0100 5297369 http://www.medworm.com/index.php?rid=4904408&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001735%2Fabstract%3Frss%3Dyes (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904408 Tue, 07 Jun 2011 16:51:08 +0100 4904408 http://www.medworm.com/index.php?rid=5144422&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000584%2Fabstract%3Frss%3Dyes Abstract: The seeds of Griffonia simplicifolia Baill. are rich in 5-HTP (5-hydroxytryptophan), a direct precursor of the neurotransmitter serotonin. In the present study we investigated the influence of the plant extract on male sexual behavior. The seed extract was orally administered to Sprague-Dawley male rats at three dose levels (25, 50 and 100mg/kg) both acutely and subchronically (daily for 9days). Mating test with receptive female rats was performed 60min after the acute treatment or the last dose when repetitively administered. Mount, intromission and ejaculation latencies and post-ejaculatory interval were recorded. Food intake and body weight were measured over the 9-day period of treatment. Microdialysis technique was used to detect the extracellular levels of serotonin (5-HT) ... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144422 Sun, 05 Jun 2011 23:00:00 +0100 5144422 http://www.medworm.com/index.php?rid=4999585&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001486%2Fabstract%3Frss%3Dyes This second edition of Bioactive Natural Products covered many areas related to natural product chemistry. Chapters 4, 5, 8, 10, 11, 13, 14 and 16–20 are new additions in the 2nd edition of the book. Since majority of the chapters are added as new additions, with many other chapters being significantly updated, the book should not be considered as a simple extension of the 1st edition, but could be treated as a new edition of book. Authors of each chapter are internationally recognized and demonstrate expertise in their own disciplinary areas. The book may be divided as five distinguished sections: detection of bioactive natural products (Chapters 2, 4, 5, 8, 9 and 11), isolation of natural products (Chapters 2, 7 and 10), chemical structure determination of natural products (Chapters 3 ... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999585 Sun, 05 Jun 2011 23:00:00 +0100 4999585 http://www.medworm.com/index.php?rid=5297367&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100122X%2Fabstract%3Frss%3Dyes Abstract: From a library of compounds of natural sources, a big series of molecules was chosen by random sampling to evaluate their in vitro antimalarial activity against Plasmodium falciparum and their antifungal activity against Candida sp. From 184 molecules tested, no molecules were active against Candida sp. (MIC>10μg/ml) whereas 13 clearly showed high antiplasmodial activity in vitro, with an IC50 less than 1μg/ml against the chloroquine-resistant strain of P. falciparum FcM29-Cameroon. The molecules with the best antiplasmodial efficacy were 10-hydroxy-ellipticin (IC50: 0.08μg/ml), tchibangensin (IC50: 0.13μg/ml), ellipticin hydrochloride (IC50: 0.17μg/ml), usambarensin (IC50: 0.23μg/ml), 7S,3S-ochropposinine oxindole (IC50: 0.25μg/ml), 3,14-dihydro-ellipticin (IC50: 0.25μg/... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297367 Wed, 25 May 2011 04:00:00 +0100 5297367 http://www.medworm.com/index.php?rid=5297377&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001206%2Fabstract%3Frss%3Dyes Abstract: Anti-Candida potential of six terpenoids were evaluated in this study against various isolates of Candida albicans (n=39) and non-C. albicans (n=9) that are differentially susceptible to fluconazole. All the six terpenoids tested, showed excellent activity and were equally effective against isolates of Candida sps., tested in this study. Linalool and citral were the most effective ones, inhibiting all the isolates at ≤0.064% (v/v). Five among the six terpenoids tested were fungicidal. Time dependent kill curve assay showed that MFCs of linalool and eugenol were highly toxic to C. albicans, killing 99.9% inoculum within seven min of exposure, while that of citronellal, linalyl acetate and citral required 15min, 1h and 2h, respectively. FIC index values (Linalool – 0.140, benzy... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297377 Fri, 20 May 2011 04:00:00 +0100 5297377 http://www.medworm.com/index.php?rid=5196688&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001164%2Fabstract%3Frss%3Dyes Abstract: Diseases caused by insect borne trypanosomatid parasites are significant, yet remain a neglected public health problem. Leishmania, a unicellular protozoan parasite is the causative organism of Leishmaniasis and is transmitted by female phlebotamine sandflies affecting millions of people worldwide. In the wake of resistance to pentavalent antimonial drugs, new therapeutic alternatives are desirable. The plant kingdom has in the past provided several affordable compounds and this review aims to provide an overview of the current status of available leishmanicidal plant derived compounds that are effective singly or in combination with conventional anti-leishmanial drugs, yet are non toxic to mammalian host cells. Furthermore, delineation of the contributory biochemical mechanisms ... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196688 Thu, 19 May 2011 23:00:00 +0100 5196688 http://www.medworm.com/index.php?rid=5144421&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001243%2Fabstract%3Frss%3Dyes Abstract: Imipenem-resistant Klebsiella pneumoniae (IRKP) were used to explore the synergistic anti-bacterial and proteomic effects of imipenem alone or in combination with epigallocatechin gallate (EGCg). The minimal inhibitory concentrations (MICs) of EGCG for 12 clinically isolated IRKP strains ranged from 300 to 650μg/ml. Each of the 12 IRKP strains experienced a 4- to 64-fold reduction in the MIC of imipenem upon co-incubation with 0.25×MIC level of EGCg. The time-kill method was used on the 12 IRKP clinical isolates to evaluate the bactericidal activities of imipenem alone or with EGCg. Compared to imipenem alone, EGCg with imipenem demonstrated enhanced bactericidal activity. Two-dimensional polyacrylamide gel electrophoresis identified eight down-regulated and four up-regulated p... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144421 Thu, 19 May 2011 23:00:00 +0100 5144421 http://www.medworm.com/index.php?rid=5196691&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001267%2Fabstract%3Frss%3Dyes Abstract: Multi drug resistance (MDR) is a major obstacle in the chemotherapeutic treatment of many human cancers. 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (DMC), a chalcone, isolated from the buds of Cleistocalyx operculatus, has been shown to have antitumor effects on human carcinoma SMMC-7721 cells in vitro and in vivo. In this paper, we studied the reversal effect and the mechanism of DMC on human hepatocellular carcinoma drug-resistant cells BEL-7402/5-FU in vitro. Administration of DMC reversed the multi-drug resistance of human hepatocellular carcinoma BEL-7402/5-FU cells significantly. DMC enhanced the sensitivity of BEL-7402/5-FU cells to 5-fluorouracil (5-FU) and doxorubicin (DOX). Staining with Hoechst 33258 and flow cytometric analysis showed that DMC has apo... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196691 Wed, 18 May 2011 23:00:00 +0100 5196691 http://www.medworm.com/index.php?rid=5196690&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001218%2Fabstract%3Frss%3Dyes Abstract: We have shown that gypenosides (Gyp) induced cell cycle arrest and apoptosis in many human cancer cell lines. However, there are no reports showing that show Gyp acts on human leukemia HL-60 cells in vitro and in a murine xenograft model in vivo. In the present study effects of Gyp on cell morphological changes and viability, cell cycle arrest and induction of apoptosis in vitro and effects on Gyp in an in vivo murine xenograft model. Results indicated that Gyp induced morphological changes, decreased cell viability, induced G0/G1 arrest, DNA fragmentation and apoptosis (sub-G1 phase) in HL-60 cells. Gyp increased reactive oxygen species production and Ca2+ levels but reduced mitochondrial membrane potential in a dose- and time-dependent manner. Gyp also changed one of the primar... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196690 Wed, 18 May 2011 23:00:00 +0100 5196690 http://www.medworm.com/index.php?rid=5196687&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001231%2Fabstract%3Frss%3Dyes Abstract: α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl3 extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC50 of 88.7μg/ml, had stronger inhibition than a positive control, acarbose, with an IC50 of 336.7μg/ml (521.5μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3,26-diol (ganoderol B). It was found to have high α-glucosidase inhibition, w... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5196687 Wed, 18 May 2011 23:00:00 +0100 5196687 http://www.medworm.com/index.php?rid=5297368&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100119X%2Fabstract%3Frss%3Dyes This study was to investigate the change in two forms of glutamic acid decarboxylase (GABA synthesized enzymes) GAD65 and GAD67 in the cortex and hippocampus areas while the anxiolytic actions induced by chronic administration of honokiol in mice. Mice treated with 7 daily injection of honokiol (1mg/kg, p.o.) caused anxiolytic action which was similar to that was induced by 7 daily injection of diazepam (2mg/kg, p.o.) in the elevated plus-maze test. In addition, the activity of hippocampal GAD65 of honokiol treated mice was significantly increased than that of the vehicle or diazepam treated groups. These data suggest that honokiol causes diazepam-like anxiolytic action, which may be mediated by altering the synthesis of GABA in the brain of mice. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5297368 Wed, 11 May 2011 04:00:00 +0100 5297368 http://www.medworm.com/index.php?rid=4783052&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001395%2Fabstract%3Frss%3Dyes (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4783052 Thu, 05 May 2011 16:20:17 +0100 4783052 http://www.medworm.com/index.php?rid=5144418&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001188%2Fabstract%3Frss%3Dyes Abstract: Danshen–Gegen (DG) decoction, an herbal formulation comprising Radix Salvia Miltiorrhiza and Radix Puerariae Lobatae, is prescribed for the treatment of coronary heart disease in Chinese medicine. Experimental and clinical studies have demonstrated that DG decoction can reduce the extent of atherosclerosis. In the present study, using an ex vivo rat model of myocardial ischemia/reperfusion (I/R) injury, we investigated the myocardial preconditioning effect of an aqueous DG extract prepared from an optimized weight-to-weight ratio of Danshen and Gegen. Short-term treatment with DG extract at a daily dose of 1g/kg and 2g/kg for 3 days protected against myocardial I/R injury in rats. The cardioprotection afforded by DG pretreatment was paralleled by enhancements in mitochondrial a... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144418 Sun, 01 May 2011 23:00:00 +0100 5144418 http://www.medworm.com/index.php?rid=4783054&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711310003430%2Fabstract%3Frss%3Dyes Abstract: Eight phenolic compounds, including (−)-epicatechin (1) and seven proanthocyanidins (2–8), were obtained from the butanol extract of Parabarium huaitingii (PHB). Their chemical structures were identified based on analyses of mass spectra (MS), NMR, CD spectra, and partial acid catalyzed thiolytic degradation. The observation made by laser scanning confocal microscope found a significant increase of the concentration of intracellular Ca2+ ([Ca2+]i) in single myocytes when the PHB was added, while compounds 1 and 3 had the same physiological effect. Further investigations showed PHB had a dose-dependent positive inotropic effect on isolated right atria and papillary muscle of left ventricle of the rat, while having no significant influence on the spontaneous beating rate of the... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4783054 Thu, 28 Apr 2011 23:00:00 +0100 4783054 http://www.medworm.com/index.php?rid=4904410&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000936%2Fabstract%3Frss%3Dyes In conclusion, oral TJ-29 administration could be useful and safe for the treatment of post-infectious prolonged cough. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904410 Sun, 24 Apr 2011 23:00:00 +0100 4904410 http://www.medworm.com/index.php?rid=5144430&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000900%2Fabstract%3Frss%3Dyes This study examined the effect of schisandrin, one of the major lignans isolated from Schisandra chinensis, on spontaneous contraction in rat colon and its possible mechanisms. Schisandrin produced a concentration-dependent inhibition (EC50=1.66μM) on the colonic spontaneous contraction. The relaxant effect of schisandrin could be abolished by the neuronal Na+ channel blocker tetrodotoxin (1μM) but not affected by propranolol (1μM), phentolamine (1μM), atropine (1μM) or nicotine desensitization, suggesting possible involvement of non-adrenergic non-cholinergic (NANC) transmitters released from enteric nerves. Nω-nitro-l-arginine methyl ester (100–300μM), a nitric oxide synthase inhibitor, attenuated the schisandrin response. The role of nitric oxide (NO) was confirmed by an increa... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144430 Thu, 21 Apr 2011 23:00:00 +0100 5144430 http://www.medworm.com/index.php?rid=5144429&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000894%2Fabstract%3Frss%3Dyes Abstract: Antibacterial activity of Lithrea molleoides extract against Proteus mirabilis has been previously reported by our group. In the present study, the compound (Z,Z)-5-(trideca-4’,7’-dienyl)-resorcinol (1) was isolated as its responsible active principle. The effects of the compound obtained and of L. molleoides extract on P. mirabilis growth and virulence factors were evaluated.Compound 1 showed MIC and MBC values of 4000μg/ml. It was found that the extract, at four times the MIC, produced complete killing of the uropathogen at 2h from the beginning of the experiment, while the alkylresorcinol, at four times the MIC, produced the same effect after 24h. Hemolysis was adversely affected in treatments with both products at 8μg/ml, while hemagglutination was not altered. The whol... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144429 Thu, 21 Apr 2011 23:00:00 +0100 5144429 http://www.medworm.com/index.php?rid=4904427&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000924%2Fabstract%3Frss%3Dyes Abstract: St. John's Wort (Hypericum perforatum L.) is a useful medication in the treatment of mild to moderate depression. By reanalysis of the data obtained from a total of 154 patients, who responded in a randomised, multicentric, double-blind, placebo-controlled study, to 6 weeks of treatment for an episode of moderate depression with either 20mg citalopram or 900mg Hypericum extract STW 3-VI, the duration of response and occurrence of relapse/recurrence were evaluated.Duration of response and occurrence of relapse/recurrence was measured by re-evaluating the responders in a controlled-clinical trial (final score of ≤10 according to HAMD at the end of the clinical trial) according to the Hamilton Rating Scale for Depression (HAMD).In total, 30 (19.5%) of the 154 responders were diagn... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904427 Thu, 21 Apr 2011 23:00:00 +0100 4904427 http://www.medworm.com/index.php?rid=5144419&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000912%2Fabstract%3Frss%3Dyes Abstract: Some Magnolia (Magnoliaceae) species are used for the empirical treatment of diabetes mellitus, but the antidiabetic properties of Magnolia dealbata have not yet been experimentally validated. Here we report that an ethanolic extract of Magnolia dealbata seeds (MDE) and its active principles honokiol (HK) and magnolol (MG) induced the concentration-dependent 2-NBDG uptake in murine 3T3-F442A and human subcutaneous adipocytes. In insulin-sensitive adipocytes, MDE 50μg/ml induced the 2-NBDG uptake by 30% respect to insulin, while HK and MG, 30μM each, did it by 50% (murine) and 40% (human). The simultaneous application of HK and MG stimulated 2-NBDG uptake by 70% in hormone-sensitive cells, on which Magnolia preparations exerted synergic effects with insulin. In insulin-resistant... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144419 Wed, 20 Apr 2011 23:00:00 +0100 5144419 http://www.medworm.com/index.php?rid=5144425&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000857%2Fabstract%3Frss%3Dyes Abstract: The present study aimed to evaluate the radioprotective efficacy of green tea polyphenols and the component ingredients against irradiated-induced damage in mice and elucidate the underlying mechanisms. Green tea polyphenols (GTP 50, 50 and 100mg/kg, p.o. daily) and its four individual components (25 and 50mg/kg, p.o. daily) were administrated to the irradiated-injured mice for 21days. The radioprotective effect on the hematopoietic system, serum cytokines, and endogenous antioxidant enzymes was studied. GTP 50 significant revert the irradiated-induced decline in hematological parameters (RBCs, WBCs, Hb), meanwhile, protected antioxidant defense system, as evidenced by decreased of serum lipid peroxidation (malonyldialdehyde) and elevation the antioxidant enzyme superoxide dismut... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144425 Sun, 17 Apr 2011 23:00:00 +0100 5144425 http://www.medworm.com/index.php?rid=4725917&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311001073%2Fabstract%3Frss%3Dyes (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4725917 Thu, 14 Apr 2011 23:00:00 +0100 4725917 http://www.medworm.com/index.php?rid=5144428&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000869%2Fabstract%3Frss%3Dyes Abstract: The in vitro antibacterial activity of taxifolin-7-O-α-l-rhamnopyranoside (TR) and its synergy with four conventional antibiotics (ampicillin (AMP), levofloxacin (LEV), ceftazidime (CAZ) and azithromycin (AZM)) against ten clinical isolates of methicillin-resistant staphylococcus aureus (MRSA) were evaluated, respectively. Individual MICs and MBCs were determined by microdilution methods following the CLSI guidelines. Anti-MRSA synergy effects were measured using the chequerboard and time–kill curve tests. MICs/MBCs (μg/ml) ranges were 32–64/64–128 for TR alone against all 10 MRSA isolates. Chequerboard method showed that significant synergies were observed for the TR/CAZ and TR/LEV combinations with FICI ranged 0.187–0.375 and 0.25–0.5, respectively. Some synergy and... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144428 Tue, 05 Apr 2011 23:00:00 +0100 5144428 http://www.medworm.com/index.php?rid=5144426&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000845%2Fabstract%3Frss%3Dyes Abstract: The present study reports for the first time, the in vivo wound healing potential of Punica granatum L. peels. A 5% (w/w) methanolic extract based-ointment was formulated and evaluated for its wound healing in guinea pigs. The ointment was applied in vivo on the paravertebral area of twelve excised wounded models once a day for 10 consecutive days. The ointment significantly enhanced the wound contraction and the period of epithelialization as assessed by the mechanical (contraction rate, tensile strength), the biochemical (increasing of collagen, DNA and proteins synthesis) and the histopathological characteristics. Such investigation was encouraged by the efficiency of the methanolic extract as antimicrobial and antioxidant. Indeed, the extract showed antioxidant activity as st... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144426 Tue, 05 Apr 2011 23:00:00 +0100 5144426 http://www.medworm.com/index.php?rid=5144420&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000560%2Fabstract%3Frss%3Dyes Abstract: Rhodomyrtone from Rhodomyrtus tomentosa (Aiton) Hassk. leaf extract has a strong antibacterial activity against the bacterial pathogen Streptococcus pyogenes. Our previous studies indicated that the bactericidal activity of rhodomyrtone might involve intracellular targets. In the present studies we followed a proteomics approach to investigate the mode of action of rhodomyrtone on S. pyogenes. For this purpose, S. pyogenes was cultivated in the presence of 0.39μg/ml rhodomyrtone, which corresponds to 50% of the minimal inhibitory concentration. The results show that the amounts of various enzymes associated with important metabolic pathways were strongly affected, which is consistent with the growth-inhibiting effect of rhodomyrtone. Additionally, cells of S. pyogenes grown in t... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144420 Sun, 27 Mar 2011 23:00:00 +0100 5144420 http://www.medworm.com/index.php?rid=5144423&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000572%2Fabstract%3Frss%3Dyes Conclusions: 10.5g Litozin® in 28 days had neither effect on clinical symptoms or laboratory measurements in patients with RA or healthy controls. This is in contrast to previous intervention studies with rose hip powder that found a reduction in the concentration of CRP. The results of the present study indicate that a daily amount of approximately 10g rose hip powder for one month has no anti-inflammatory and/or antioxidant effect. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=5144423 Mon, 21 Mar 2011 00:00:00 +0100 5144423 http://www.medworm.com/index.php?rid=4999584&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000596%2Fabstract%3Frss%3Dyes Abstract: It is known that (−)-linalool is a competitive antagonist of NMDA receptors, which play a key role in the learning and memory processes; however, only a few studies have reported a possible interference of (−)-linalool in memory. The purpose of this study was to investigate the (−)-linalool effects on acquisition of short- and long-term memories through the objects recognition task, inhibitory avoidance test and habituation to a novel environment. Furthermore, the open field test was used to investigate the interference of (−)-linalool in motivation, locomotion and exploration by animals. Wistar male adult rats received an intraperitoneal injection (i.p.) of saline (NaCl 0.9%), tween 5% or (−)-linalool (50 or 100mg/kg) before training in the tasks; MK-801 (0.1mg/kg), a ... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999584 Mon, 21 Mar 2011 00:00:00 +0100 4999584 http://www.medworm.com/index.php?rid=4999571&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000547%2Fabstract%3Frss%3Dyes Abstract: Traditional uses of Achillea millefolium L. (Asteraceae) include the treatment of cardiovascular diseases. In the present study, we used anesthetized rats to assess the hypotensive effect of a hydroethanolic extract (HEAM), and its dichloromethane (DCM), ethyl acetate (EA), butanolic (BT), and dichloromethane-2 (DCM-2) fractions, besides the flavonoid artemetin, isolated from A. millefolium. The oral administration of HEAM (100–300mg/kg), DCM (20mg/kg), DCM-2 (10–30mg/kg), but not EA (10mg/kg) and BT (50mg/kg) fractions significantly reduced the mean arterial pressure (MAP) of normotensive rats. The phytochemical analysis by NMR 1H of DCM and DCM-2 fractions revealed high amounts of artemetin, that was isolated and administered by either oral (1.5mg/kg) or intravenous (0.15�... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999571 Mon, 21 Mar 2011 00:00:00 +0100 4999571 http://www.medworm.com/index.php?rid=4725930&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100050X%2Fabstract%3Frss%3Dyes Abstract: The ability of a soy-based high-phytoestrogen diet (nutritional intervention) or genistein (pharmacological intervention), to limit ischemic brain damage in Wistar, Wistar–Kyoto (WKY) and spontaneously hypertensive (SHR) rats, has been assessed. As to the nutritional intervention, two groups from each strain received either a phytoestrogen-free (PE-0) or a high-phytoestrogen (PE-600) diet from weaning to adulthood. As to the pharmacological intervention, all animals were fed the standard soy-free AIN-93G diet and subsequently separated into two groups from each strain to receive either pure genistein (aglycone form, 1mg/kg/day intraperitoneal) or vehicle at 30min reperfusion. After an episode of 90min ischemia (intraluminal thread procedure) followed by 3 days reperfusion, cere... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4725930 Mon, 21 Mar 2011 00:00:00 +0100 4725930 http://www.medworm.com/index.php?rid=4999579&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000419%2Fabstract%3Frss%3Dyes Abstract: Kidney stones are a common problem for which inadequate prevention exists. We recruited ten recurrent kidney stone formers with documented calcium oxalate stones into a two phased study to assess safety and effectiveness of Cystone®, an herbal treatment for prevention of kidney stones. The first phase was a randomized double-blinded 12 week cross over study assessing the effect of Cystone® vs. placebo on urinary supersaturation. The second phase was an open label one year study of Cystone® to determine if renal stone burden decreased, as assessed by quantitative and subjective assessment of CT. Results revealed no statistically significant effect of Cystone® on urinary composition short (6 weeks) or long (52 weeks) term. Average renal stone burden increased rather than decrea... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999579 Fri, 18 Mar 2011 00:00:00 +0100 4999579 http://www.medworm.com/index.php?rid=4601806&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000730%2Fabstract%3Frss%3Dyes (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4601806 Tue, 15 Mar 2011 00:00:00 +0100 4601806 http://www.medworm.com/index.php?rid=4999583&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000535%2Fabstract%3Frss%3Dyes Abstract: In Nigeria, Mucuna pruriens seeds are locally prescribed as an oral prophylactic for snake bite and it is claimed that when two seeds are swallowed they protect the individual for a year against snake bites. In order to understand the Mucuna pruriens antisnake properties, the proteins from the acqueous extract of seeds were purified by three chromatographic steps: ConA affinity chromatography, tandem anionic–cationic exchange and gel filtration, obtaining a fraction conventionally called gpMucB. This purified fraction was analysed by SDS–PAGE obtaining 3 bands with apparent masses ranging from 20 to 24kDa, and by MALDI-TOF which showed two main peaks of 21 and 23kDa and another small peak of 19kDa. On the other hand, gel filtration analysis of the native protein indicated a m... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999583 Mon, 14 Mar 2011 00:00:00 +0100 4999583 http://www.medworm.com/index.php?rid=4999582&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000523%2Fabstract%3Frss%3Dyes This study suggests that 54mg/day of GEN is the threshold dose for efficacy. In addition, supplemental calcium and vitamin D3, beyond normal dietary intake do not enhance the effects of genistein on improving measures of bone loss. This observation has implications regarding the use of calcium and vitamin D3 supplementation. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999582 Mon, 14 Mar 2011 00:00:00 +0100 4999582 http://www.medworm.com/index.php?rid=4783062&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000559%2Fabstract%3Frss%3Dyes In this study, we tested the potential of kava extract to potentiate APAP-induced hepatocyte cytotoxicity. In rat primary hepatocytes, co-treatment with kava and APAP caused 100% loss of cell viability, while the treatment of kava or APAP alone caused ∼50% and ∼30% loss of cell viability, respectively. APAP-induced glutathione (GSH) depletion was also potentiated by kava. Co-exposure to kava decreased cellular ATP concentrations, increased the formation of reactive oxygen species, and caused mitochondrial damage as indicated by a decrease in mitochondrial membrane potential. In addition, similar findings were obtained from a cultured rat liver cell line, clone-9. These observations indicate that kava potentiates APAP-induced cytotoxicity by increasing the magnitude of GSH depletion, re... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4783062 Mon, 14 Mar 2011 00:00:00 +0100 4783062 http://www.medworm.com/index.php?rid=4601822&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000122%2Fabstract%3Frss%3Dyes On 10 September 2010 Professor Dr. Fritz H. Kemper retired from the European Scientific Cooperative on Phytotherapy (ESCOP) having been President for more than 18 years, and at the wheel of ESCOP from its beginning in 1989. Thanks to his great personal commitment, his scientific competence and his diplomatic skills Professor Kemper steered its course safely through many a storm. We, his colleagues from ESCOP, very much regret his retirement and would like to express our sincere appreciation and admiration for his activity and his energy over such a long period and for his great success in establishing the scientifically based phytotherapy on a European level. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4601822 Wed, 09 Mar 2011 00:00:00 +0100 4601822 http://www.medworm.com/index.php?rid=4999574&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000468%2Fabstract%3Frss%3Dyes Abstract: Opioids are extensively used for the management of both chronic malignant and non malignant pains. One major serious limitation associated with chronic use of opioids is the development of tolerance to its analgesic effect. The effect of Bacopa monnieri, a renowned ayurvedic medicine for acquisition and expression of morphine tolerance in mice, was investigated. Bacopa monnieri, n-Butanol fraction was analyzed on High performance liquid chromatography (HPLC), for Bacopaside A major components i.e. Bacoside A3, Bacopaside ll and Bacosaponin C. Antinociceptive effect of n-Butanol extract of Bacopa monnieri (n Bt-ext BM) (5, 10 and 15mg/kg) was assessed on hot plate. Effect of different doses of n Bt-ext BM on morphine antinociception was also assessed. n Bt-ext BM was also screened... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999574 Tue, 08 Mar 2011 00:00:00 +0100 4999574 http://www.medworm.com/index.php?rid=4999569&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000444%2Fabstract%3Frss%3Dyes Abstract: The hepatoprotective effect of birch bark extract (BBE) in patients with chronic hepatitis C (CHC) was studied. Forty-two patients with serologically confirmed chronic hepatitis C were treated for 12 weeks with 160mg standardized BBE per day. The primary outcome parameter measured was the rate of alanine aminotransferase (ALT) normalization after 12 weeks. Secondary parameters included the course of ALT, aspartate aminotransferase (AST) levels, quantitative HCV RNA levels, subjective symptoms associated with CHC (fatigue, abdominal discomfort, depression, and dyspepsia), safety and compliance. The qualitative–quantitative analysis of BBE was made using high performance liquid chromatography to confirm the presence of 75% betulin and 3.5% betulinic acid. Significant differences ... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999569 Tue, 08 Mar 2011 00:00:00 +0100 4999569 http://www.medworm.com/index.php?rid=4601821&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000511%2Fabstract%3Frss%3Dyes Abstract: Estrogenic activities of ethanol extract and its active components from Psoralea corylifolia L. were studied using various in vitro assays. The main components from ethanol extract were analyzed to be bakuchiol, psoralen, isobavachalcone, isobavachromene, and bavachinin. In a fractionation procedure, hexane and chloroform fractions showed estrogenic activity in yeast transactivation assay and E-screen assay. In yeast transactivation assay, ethanol extract, hexane, and chloroform fractions showed significantly higher activities at a concentration of 1.0ng/ml, and bakuchiol at the concentration of 10−6M was showed the highest activity, especially, which was higher than genistein at the same concentration. In E-screen assay, cell proliferation of bakuchiol (10−6M) showed similar... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4601821 Tue, 08 Mar 2011 00:00:00 +0100 4601821 http://www.medworm.com/index.php?rid=4999581&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100047X%2Fabstract%3Frss%3Dyes Abstract: The antiplatelet and antithrombotic effects of ent-16β,17-dihydroxy-kauran-19-oic acid (DDKA) isolated from Siegesbeckia pubescens were investigated with different methods both in vitro and in vivo. We tested the antithrombotic activity of DDKA in arterio-venous shunt model. The effects of DDKA on adenosine diphosphate (ADP)-, Thrombin-, Arachidonic acid-induced rat platelets aggregation were tested in vitro. We also assessed its bleeding side effect by measuring coagulation parameters after intravenous administration for 5days and investigated the potential mechanisms underlying such activities. In vivo, DDKA significantly reduced thrombus weight in the model of arterio-venous shunt. Meanwhile, DDKA increased plasma cAMP level determined by radioimmunoassay in the same model. N... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999581 Mon, 07 Mar 2011 00:00:00 +0100 4999581 http://www.medworm.com/index.php?rid=4999580&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000456%2Fabstract%3Frss%3Dyes In conclusion, flavonoid aglycones in SDF could promote differentiation and mineralization of osteoblastic UMR 106 cells in vitro, which was explained by activation of ER signaling pathway. This study provides scientific evidences for the conduction of in vivo experiments to confirm potential effects of flavonoid aglycones on preventing OVX-induced osteoporosis. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999580 Mon, 07 Mar 2011 00:00:00 +0100 4999580 http://www.medworm.com/index.php?rid=4999578&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000420%2Fabstract%3Frss%3Dyes Abstract: Three novel compounds with spiro-5, 6-lactone ring skeleton has been isolated from the fermentation broth of Massrison sp. which could be isolated repeatedly from wild Rehmannia glutinosa. Psetariae oryza P-2b was applied to guide fractionation of bioactive compounds produced by Massrison sp. The molecular structures were established by a variety of one- and two-dimensional NMR experiments and the compounds with similar skeleton were reported for the first time from endophytic fungi of terraneous plant. Antifungal and cytotoxic activities of the compounds were tested, compounds 2 and 3 displayed stronger antifungal and cytotoxic activities. The compounds have the potential to be antibiotic against fungal pathogens and tumor cells. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999578 Mon, 07 Mar 2011 00:00:00 +0100 4999578 http://www.medworm.com/index.php?rid=4999575&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000481%2Fabstract%3Frss%3Dyes In this study, the four amides were prepared by chemical synthesis and their protective effects on H2O2-induced apoptosis in PC-12 cells were investigated. The syntheses were relatively simple and the yields were more than 43%. Using NMR spectroscopic methods, the chemical structures of veskamide, enferamide, becatamide, and oretamide were confirmed. The decreasing order of the protective effects on H2O2-induced apoptosis was becatamide>enferamide≥oretamide>veskamide. In fact, becatamide suppressed H2O2-induced mitochondrial membrane depolarization in a dose-dependent manner. At the concentration of 10μM, becatamide maintained mitochondrial membrane depolarization at 16% compared to 51% in H2O2-treated PC-12 cells (P (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999575 Mon, 07 Mar 2011 00:00:00 +0100 4999575 http://www.medworm.com/index.php?rid=4999573&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000493%2Fabstract%3Frss%3Dyes Abstract: The anti-influenza A/PR/8/34 virus activity of silymarin was evaluated in MDCK cells and investigated the effect of silymarin on synthesis of viral mRNAs. Silymarin was investigated for its antiviral activity against influenza A/PR virus using a cytopathic effect (CPE) reduction method. Silymarin exhibited anti-influenza A/PR/8/34 virus activity of 98% with no cytotoxicity at the concentration of 100μg/ml reducing the formation of a visible CPE. Oseltamivir also did show moderate antiviral activity of about 52% against influenza A/PR/8/34 virus at the concentration of 100μg/ml. Furthermore, the mechanism of anti-influenza virus action in the inhibition of viral mRNA synthesis was analyzed by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR), and the data indicated an inh... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999573 Mon, 07 Mar 2011 00:00:00 +0100 4999573 http://www.medworm.com/index.php?rid=4999570&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000432%2Fabstract%3Frss%3Dyes Abstract: The neuronal damage following cerebral ischemia is a serious risk to stroke patients. The aim of this study was to investigate the neuroprotective effects of alkaloid extract from Leonurus heterophyllus (LHAE) on cerebral ischemic injury. After 24h of reperfusion following ischemia for 2h induced by middle cerebral artery occlusion (MCAO), some rats were intraperitoneally administered different doses of LHAE (3.6, 7.2, 14.4mg/kg, respectively). Neurological examination was measured in all animals. Infarct volume, myeloperoxidase (MPO) activity, levels of nitrate/nitrite metabolite (NO) and apoptosis ratio of nerve fiber in brain were determined. The results showed that LHAE at 7.2mg/kg or 14.4mg/kg exerted significantly decreasing neurological deficit scores and reducing the infa... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999570 Mon, 07 Mar 2011 00:00:00 +0100 4999570 http://www.medworm.com/index.php?rid=4999577&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000171%2Fabstract%3Frss%3Dyes Abstract: The aim of this study was to detect the antitumor properties of Croatian propolis in BALB/c male and female mice injected with 4T1 mammary carcinoma. Furthermore, the gender-dependence of this effect and the possible involvement of combined effect of propolis and 5-Fluorouracil (5FU) on dihydropyrimidine dehydrogenase (DPD) transcriptional and translational level, were determined. In combination with 5FU propolis treatment induced gender-related effects. The results of the study revealed that pretreatment of mice with propolis combined with 5FU treatment prolonged the suppressive effect of 5FU on tumor growth and reduced the number of metastasis only in male mice. Only males pretreated with propolis prior to 5FU administration had decreased DPD protein level indicating higher sen... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999577 Mon, 28 Feb 2011 00:00:00 +0100 4999577 http://www.medworm.com/index.php?rid=4999576&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000183%2Fabstract%3Frss%3Dyes Abstract: The seeds of Griffonia simplicifolia Baill., a tropical shrub native to West Africa, are rich in 5-hydroxy-l-tryptophan (5-HTP), a direct precursor in the synthesis of serotonin (5-HT). In spite of the modern therapeutic application of Griffonia simplicifolia seed extract in mood disorders, no scientific evidence has been provided till now. For this reason the aim of our study was to investigate the effect of Griffonia simplicifolia seed extract on anxiety behavior. Griffonia simplicifolia seed extract, dosed at 1, 5, 10 and 25mg/kg, was orally administered in rats which were submitted to the dark–light test and open field test, 60min after the treatment. In the dark–light test, the administration of the extract at the doses of 10 and 25mg/kg was able to significantly increas... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4999576 Mon, 28 Feb 2011 00:00:00 +0100 4999576 http://www.medworm.com/index.php?rid=4904434&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000195%2Fabstract%3Frss%3Dyes This study aimed at investigating the in vitro transport of P57 across excised porcine intestinal and buccal mucosa in a Sweetana–Grass diffusion apparatus. For both the intestinal and buccal experiments, the transport of pure P57 was compared to that obtained from a crude plant extract. Bi-directional transport experiments were conducted across the intestinal tissue in two different media namely Krebs–Ringer bicarbonate buffer and simulated intestinal fluid. Apical-to-basolateral transport experiments were conducted across the buccal tissue in two different media namely Krebs–Ringer bicarbonate buffer and artificial saliva. Apparent permeability coefficient (Papp) and flux values were calculated and analysed by means of a one-way repeated analysis of variance (ANOVA) to determine if... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904434 Mon, 28 Feb 2011 00:00:00 +0100 4904434 http://www.medworm.com/index.php?rid=4904424&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000134%2Fabstract%3Frss%3Dyes Abstract: The function of p53 induced by ganoderic acids (GAs) in anti-invasion was unknown, although our previous work reported the inhibition of tumor invasion and metastais by Ganoderic acid T (GA-T). This work indicated that GA-T promoted cell aggregation, inhibited cell adhesion and surpressed cell migration with a dose-dependent manner in human colon tumor cell lines of HCT-116 p53+/+ and p53−/−. Furthermore, comparing the ratios of HCT-116 p53+/+ and p53−/− cells, p53 modified GA-T inhibition of migration and adhesion and GA-T promotion of cell aggregation, and p53 also modified GA-T inhibition of NF-κB nuclear translocation, IκBα degradation, and down-regulation of urokinase-type plaminogen activator (uPA), matrix metalloproteinase-2/9 (MMP-2/9), inducible nitric oxide s... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904424 Mon, 28 Feb 2011 00:00:00 +0100 4904424 http://www.medworm.com/index.php?rid=4904411&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000146%2Fabstract%3Frss%3Dyes Abstract: The aim of the study is to assess the hypotensive properties of the hydro-ethanolic crude root extract (CRE), the n-butanol fraction (FBtOH) and nuatigenin-3-O-β-chacotriose, from Solanum sisymbriifolium Lam., in adrenal regeneration hypertension+deoxycorticosterone acetate (ARH+DOCA) rats, following a chronic administration. The roots of S. sisymbriifolium Lam. (Solanaceae) were extracted by reflux with ethanol–water 7:3 and the active extract was fractionated by bioassay-guided liquid-liquid separation. Nuatigenin-3-O-β-chacotriose (B3-1) was identified as the main hypotensive compound from the crude drug by spectroscopic methods. Immature Wistar rats of both sexes were submitted to both surgery and deoxycorticosterone acetate treatment to obtain adrenal regeneration hypert... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904411 Mon, 28 Feb 2011 00:00:00 +0100 4904411 http://www.medworm.com/index.php?rid=4601814&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000158%2Fabstract%3Frss%3Dyes In conclusion, 4-hydroxycordoin exerts inhibitory effects on two important virulence factors of C. albicans: biofilm formation or yeast-hyphal transition. This suggests that 4-hydroxycordoin may have a therapeutic potential for C. albicans infections. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4601814 Mon, 28 Feb 2011 00:00:00 +0100 4601814 http://www.medworm.com/index.php?rid=4904412&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100016X%2Fabstract%3Frss%3Dyes Abstract: The 2 kidney, 1-clip (2K, 1C) model of hypertension was used to investigate the potential antihypertensive effect of a standardized leaf extract of Ginkgo biloba (EGb 761). Clipping of the renal artery resulted in gradual elevation of the systolic blood pressure (SBP) reaching a plateau after 4 weeks of surgery. Treatment of hypertensive rats with EGb 761 (60, 90, 180mg/kg/day orally) was therefore started 4 weeks after surgery and continued for 3 weeks. This led to a dose-dependent reduction in SBP with no significant change in heart rate. Control hypertensive rats showed a significant elevation of total protein thiols (Pr-SHs level) in both clipped and non-clipped kidneys as well as in the serum. However, glutathione peroxidase (GSH-Px) activity was decreased in the clipped kid... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904412 Fri, 25 Feb 2011 00:00:00 +0100 4904412 http://www.medworm.com/index.php?rid=4595547&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711310002552%2Fabstract%3Frss%3Dyes In this study, we examined the inhibitory potential of extract of G. glabra (GutGard™) root and its phytoconstituents (glabridin, glycyrrhizin, and isoliquiritigenin) on both cyclooxygenase (COX) and lipoxygenase (LOX) products in order to understand the mechanism of its anti-inflammatory action. Inhibitory effect of GutGard™ and its phytoconstituents on lipopolysaccharide (LPS) induced prostaglandin E2 (PGE2), calcimycin (A23187) induced thromboxane (TXB2), and leukotriene (LTB4) release was studied using murine macrophages (J774A.1) and human neutrophil (HL-60) cells. Results revealed that, G. glabra and glabridin significantly inhibited PGE2, TXB2 (COX) and LTB4 (LOX), while, isoliquiritigenin exerted inhibitory effect only against COX products but failed to suppress LOX product. Ho... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4595547 Tue, 15 Feb 2011 00:00:00 +0100 4595547 http://www.medworm.com/index.php?rid=4595540&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000341%2Fabstract%3Frss%3Dyes (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4595540 Tue, 15 Feb 2011 00:00:00 +0100 4595540 http://www.medworm.com/index.php?rid=4904436&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000031%2Fabstract%3Frss%3Dyes Abstract: Twelve flavonoids (1–12), isolated from Glycyrrhiza glabra roots were evaluated for their pancreatic lipase (PL) inhibitory activity in vitro. The structures of the isolated compounds were elucidated by spectroscopic methods. Amongst all the compounds 7, 8, 10 and 11 showed strong inhibition against PL with IC50 values of 7.3μM, 35.5μM, 14.9μM and 37.6μM, respectively. Molecular docking studies on the most active compound 7 revealed that it binds with the key amino acid residues of the PL active site. In silico absorption, distribution, metabolism and excretion (ADME) parameters were also computed on the active compounds to determine their preliminary pharmacokinetic properties. Further, investigations were carried out to determine the antiobesity and lipid lowering effects... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904436 Mon, 14 Feb 2011 00:00:00 +0100 4904436 http://www.medworm.com/index.php?rid=4904435&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000092%2Fabstract%3Frss%3Dyes In this study, we found that TFY could significantly reduce the writhing times induced by acetic acid and licking foot response induced by formalin, and extend the writhing latent period. But the analgesic effect was not observed at hot-plate test. Meanwhile, experimental migrainous model induced by nitroglycerin was used to investigate the therapeutic effect of TFY. Compared with the control group, the levels of plasma calcitonin gene related to peptide (CGRP), serum nitric oxide (NO) and contents of brain dopamine (DA) in TFY administration groups were significantly decreased, and the levels of plasma endothelin (ET) and contents of brain 5-hydroxytryptamine (5-HT) and norepinephrine (NE) were remarkably increased, also the ratio of ET/NO was clearly corrected. Furthermore, the improving... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904435 Mon, 14 Feb 2011 00:00:00 +0100 4904435 http://www.medworm.com/index.php?rid=4904414&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000043%2Fabstract%3Frss%3Dyes Abstract: Metabolic syndrome is a cluster of risk factors including insulin resistance and type 2 diabetes and is found to associate partly with chronic stress at work in human. Adiponectin circulates in mammal blood mainly as a low molecular weight (LMW) trimer, hexamer, and a high molecular weight (HMW) multimers. Low circulating levels of adiponectin are related to metabolic syndrome. We have then investigated the influence of immobilization stress on plasma adiponectin concentrations in mice. Relative LMW and HMW adiponectin levels were markedly reduced by immobilization stress (0.66±0.07 and 0.59±0.06 after 102h, respectively), significantly different from the control values (p (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904414 Mon, 14 Feb 2011 00:00:00 +0100 4904414 http://www.medworm.com/index.php?rid=4904437&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000067%2Fabstract%3Frss%3Dyes The objective of this study was to determine whether endophytic fungi isolated from V. minor produce vincamine. Primary screening was carried out using Dragendorff's and Mayer's reactions, and strain re-selection was made by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC) to identify the fermentation products of the selected strain. We isolated 10 endophytic fungal strains from V. minor. An extract from one (Vm-J2), showed positive reactions with both Dragendorff's and Mayer's reagents. The strain had a component with the same TLC Rf value and HPLC retention time as authentic vincamine. Therefore, the fungus appeared to produce the same bioactive ingredient, vincamine, as the host plant. The prospect of using endophytic fungi to produce the phytoactive com... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904437 Fri, 11 Feb 2011 00:00:00 +0100 4904437 http://www.medworm.com/index.php?rid=4904417&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000079%2Fabstract%3Frss%3Dyes Abstract: Our earlier studies showed that DATS induced apoptosis in human colon cancer HT29 and colo 205 cell lines in vitro. However, there is no report to show that DATS induced apoptosis in vitro and inhibited CT26 cancer cells in vivo on a murine allograft animal model. In vitro studies, the results indicated that DATS induced morphological changes and induction of apoptosis in CT26 cells. In vivo studies, CT26 cancer cells were implanted into BALB/c mice and groups of mice were treated with vehicle, DATS (10 and 50mg/kg of body weight). DATS were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with vehicle or with 10 and 50mg/kg of DATS resulted in a reduction in tumor volume and weight. Tumor volume and total... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904417 Fri, 11 Feb 2011 00:00:00 +0100 4904417 http://www.medworm.com/index.php?rid=4904416&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000055%2Fabstract%3Frss%3Dyes In this study, we have evaluated effects of oral administration of animal fat (beef tallow) and palmitate on mouse serum adiponectin level. Oral administrations of beef tallow and palmitate significantly suppressed serum adiponectin levels into around half of the initial level from 48 to 96h after administration compared with the case of corn oil (P (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904416 Fri, 11 Feb 2011 00:00:00 +0100 4904416 http://www.medworm.com/index.php?rid=4595544&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131000228X%2Fabstract%3Frss%3Dyes In conclusion, TAAqE-induced cardiotonic action via enhancing SR function, a unique action minimizing the occurrence of arrhythmias, makes TAAqE a promising and relatively safe cardiotonic beneficial to the healthy heart and the treatment for chronic heart disease. The cardiotonic effect of TAAqE is consistent with the therapeutic property of TA bark used in ayurvedic medicine. The method of administration and/or selective omission of hydrophobic components from bark powder could be crucial to the efficacy and safety of TA bark in cardiac therapy and uses as over-the-counter supplements. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4595544 Fri, 11 Feb 2011 00:00:00 +0100 4595544 http://www.medworm.com/index.php?rid=4904433&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000080%2Fabstract%3Frss%3Dyes In this study a 58kDa Achyranthes protein (Ap) was isolated from Achyranthes aspera using standard protocols and their effects on the rat sperm was studied in vitro in comparison with nonoxynol-9 (N-9). The sperm immobilization studies showed that about 150μg of Ap was able to immobilize sperms completely within seconds at a lower concentration than N-9 (250μg). The sperm revival test revealed that the spermicidal effect was irreversible. There was also a significant reduction in sperm viability and hypo-osmotic swelling in the Ap-treated and N-9 treated groups in comparison to the control. In the Ap and N-9 treated groups the number of acrosome reacted cells were found to be high and it also caused agglutination of the sperms indicating the loss of intactness of the plasma membrane whic... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904433 Thu, 10 Feb 2011 00:00:00 +0100 4904433 http://www.medworm.com/index.php?rid=4904423&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000109%2Fabstract%3Frss%3Dyes In this study, fractionated extracts of Curcuma wenyujin and Chrysanthemum indicum were tested for their potential to modulate the MDR phenotype and function of P-gp in MCF-7/ADR and A549/Taxol cells in vitro. Fractions C. wenyujin C10, E10 from Curcuma wenyujin, and C. indicum E10 from Chrysanthemum indicum, exhibited significant effects in sensitization of these resistant cancer cells at non-toxic concentration to doxorubicin and docetaxel by MTT method. They also increased the intracellular doxorubicin accumulation and retention in MCF-7/ADR cells. In mechanism study, an increase of Rh123 accumulation and a decrease of Rh123 efflux were observed in MCF-7/ADR cells treated with these fractions, indicating a blockage of the activity of P-gp. Furthermore, C. wenyujin C10 had the ability to... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904423 Thu, 10 Feb 2011 00:00:00 +0100 4904423 http://www.medworm.com/index.php?rid=4595555&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711311000110%2Fabstract%3Frss%3Dyes The Publisher regrets that in the above manuscript the following errors occurred. Page 864 last sentence reads: “In addition in the study of Khajuria et al. (2008) the authors demonstrated that oral administration of 1–10mg/kg of a biopolymeric fraction (BOS 2000) from the plant BS decreased levels of IL-4, IFN-γ and TNF-α in the serum. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4595555 Wed, 09 Feb 2011 00:00:00 +0100 4595555 http://www.medworm.com/index.php?rid=4904415&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131100002X%2Fabstract%3Frss%3Dyes Abstract: The aim of this study was to determine the most effective hypoglycemic component of polysaccharides from Opuntia dillenii Haw. by preliminary screening and to specifically study the antidiabetic effects of O. dillenii polysaccharide (ODP)-Ia in mice with streptozotocin (STZ)-induced diabetes. Three kinds of ODPs – ODP-Ia, ODP-Ib, and ODP-II′ – were isolated by using an ultrasonic extraction method and diethylaminoethyl (DEAE)-Sepharose fast-flow column chromatography. The mice were administered ODPs for 3 weeks. Gavage administration of ODP-Ia significantly decreased (P (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904415 Tue, 08 Feb 2011 00:00:00 +0100 4904415 http://www.medworm.com/index.php?rid=4904422&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711310004095%2Fabstract%3Frss%3Dyes Abstract: Resveratrol (3,4′,5-trihydroxy-trans-stilbene), one of secondary metabolites of low molecular weight present in plant, has various important biological effects. It can induce apoptosis in human leukemia cell types in vitro, although the mechanism is not fully understood. In the present study, we demonstrated reduced viability and DNA synthesis, as well as increased proportion of the subdiploid cell population, in HL-60 cells as determined by cell cycle analysis with resveratrol. Resveratrol treatment resulted in a gradual time-dependent decrease in the expression of anti-apoptotic Bcl-2 and increase in that of Bax, annexin A1, growth arrest- and DNA damage-induced gene 45α (GADD45α), and cleaved caspase-3. In addition, resveratrol markedly increased caspase-3 activity in cell... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904422 Mon, 31 Jan 2011 00:00:00 +0100 4904422 http://www.medworm.com/index.php?rid=4904426&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711310004083%2Fabstract%3Frss%3Dyes Abstract: Total saponins extracted from the caudexes and leaves of Panax notoginseng (SCLPN) have been used in the clinic for improving mental function, treating insomnia, and alleviating anxiety. The present study evaluated the potential antidepressant activity of SCLPN in rodent models of depression and the mechanism of action of SCLPN. Mice were received SCLPN at doses of 10–1000mg/kg daily for 1, 7, and 14 days and then were subjected to the forced swim test and locomotor activity test. The results showed that SCLPN decreased immobility time in the forced swim test, with little effect on locomotion. In the chronic mild stress model, chronic SCLPN treatment (70mg/kg) reversed the rats’ depression-like behavior. Furthermore, SCLPN exerted its antidepressant-like effect by increasing ... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904426 Fri, 28 Jan 2011 00:00:00 +0100 4904426 http://www.medworm.com/index.php?rid=4904431&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711310004101%2Fabstract%3Frss%3Dyes In conclusion, these results give a rational base for the topical use of Gencydo® in treatment of allergic disorders through the down regulation of soluble mediators, which are essential for the initiation and maintenance of allergic reactions. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904431 Mon, 24 Jan 2011 00:00:00 +0100 4904431 http://www.medworm.com/index.php?rid=4904432&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711310004058%2Fabstract%3Frss%3Dyes Abstract: Crataegus laevigata is a medicinal plant most commonly used for the treatment of heart failure and psychosomatic disorders. Based on previous experimental findings, this double-blind placebo-controlled study was aimed at finding beneficial effects of C. laevigata on biomarkers of coronary heart disease (CHD). The study included 49 diabetic subjects with chronic CHD who were randomly assigned to the treatment for 6 months with either a micronized flower and leaf preparation of C. laevigata (400mg three times a day) or a matching placebo. Blood cell count, lipid profile, C-reactive protein, neutrophil elastase (NE) and malondialdehyde were analyzed in plasma at baseline, at one month and six months. The main results were that NE decreased in the C. laevigata group compared to the p... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904432 Tue, 18 Jan 2011 00:00:00 +0100 4904432 http://www.medworm.com/index.php?rid=4904425&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711310004071%2Fabstract%3Frss%3Dyes Conclusions: The present findings support the existence of physiological and psychological effects of saffron odor in women. Our results indicate that saffron odor exert some effects in the treatment of PMS, dysmenorrhea and irregular menstruation. This is the first report to suggest that saffron odor may be effective in treating menstrual distress. (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904425 Tue, 18 Jan 2011 00:00:00 +0100 4904425 http://www.medworm.com/index.php?rid=4904421&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131000406X%2Fabstract%3Frss%3Dyes Abstract: Curcumin (CM), a well-known dietary pigment derived from Curcuma longa L., possess anticancer activities against a variety of tumors including human breast carcinoma. In combination with docetaxel, CM has been used in breast cancer management in the clinic. In order to explore the possible mechanism of anticancer activity of CM, in the present study, we aimed to identify proteins involved in the anticancer activity of CM in human breast cancer cell line MCF-7 using the two-dimensional electrophoresis (2-DE)-based proteomic analysis. MCF-7 cells were cultured at 37°C in an atmosphere of 5.0% CO2. All the following experiments were repeated three times. Cell viability assay showed that after a 48-h incubation CM dose-dependently inhibited cell growth with an IC50 value of 47.42μM... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904421 Tue, 18 Jan 2011 00:00:00 +0100 4904421 http://www.medworm.com/index.php?rid=4363155&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS094471131000423X%2Fabstract%3Frss%3Dyes (Source: Phytomedicine) Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4363155 Sat, 15 Jan 2011 00:00:00 +0100 4363155 http://www.medworm.com/index.php?rid=4904413&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711310003983%2Fabstract%3Frss%3Dyes In this study, we examined the anti-obesity effects and mechanism of action of shiikuwasa peel extract (SE) using high-fat diet (HFD)-induced obese mice. Mice were fed a low-fat diet (LFD), HFD or HFD containing 1% or 1.5% (w/w) SE (HFD+1 SE and HFD+1.5 SE, respectively) for 5 weeks. The body weight gain and white adipose tissue weight were significantly decreased in the HFD+1.5 SE group compared with the HFD group. The plasma triglyceride and leptin levels were also significantly reduced in the HFD+1.5 SE group compared with the HFD group. Histological examinations showed that the sizes of the adipocytes were significantly smaller in the HFD+1.5 SE group than in the HFD group. The HFD+1.5 SE group also showed significantly lower mRNA levels of lipogenesis-related genes, such as activating... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904413 Mon, 10 Jan 2011 00:00:00 +0100 4904413 http://www.medworm.com/index.php?rid=4904430&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711310004010%2Fabstract%3Frss%3Dyes Abstract: Epilepsy is a chronic neurological disorder affecting 1% population worldwide. A number of experimental studies have reported anticonvulsant, neuroprotective and antioxidant activity of certain natural products like curcumin, an active ingredient of turmeric. The present study was designed to explore the effect of acute administration of curcumin at doses 50, 100 and 200mg/kg, orally (p.o.) pentylenetetrazole-induced kindling in mice. Further two oxidative stress markers viz., malondialdehyde (MDA) and glutathione were estimated in brain tissues of rodents. Curcumin (50, 100 and 200mg/kg, p.o.) dose dependently suppressed the progression of kindling in mice. In addition, the increased levels of MDA and glutathione were also reduced by curcumin in kindled animals. These results su... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904430 Thu, 06 Jan 2011 00:00:00 +0100 4904430 http://www.medworm.com/index.php?rid=4904418&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711310004046%2Fabstract%3Frss%3Dyes This study investigates the anti-inflammatory effects of a diterpenoid, kaurenoic acid, isolated from the root of Aralia continentalis (Araliaceae). To determine its anti-inflammatory effects, LPS-induced RAW264.7 macrophages were treated with different concentrations of kaurenoic acid and carrageenan-induced paw edema mice model was used in vivo. Kaurenoic acid (ent-kaur-16-en-19-oic acid) dose-dependently inhibited nitric oxide (NO) production, prostaglandin E2 (PGE2) release, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression at micromolar concentrations in LPS-induced RAW264.7 macrophages with IC50 (the half maximal inhibitory concentration) values of 51.73 (±2.42) μM and 106.09 (±0.27) μM in NO production and PGE2 release, respectively. Kaurenoic acid a... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4904418 Thu, 06 Jan 2011 00:00:00 +0100 4904418 http://www.medworm.com/index.php?rid=4725918&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711310004034%2Fabstract%3Frss%3Dyes Abstract: The only saponin drug currently prescribed in any significant amount in monotherapy medicines is ivy. This post-marketing surveillance study (PMSS) aimed at investigating the tolerability and safety of film-coated tablets containing ivy leaves dry extract (extracting medium: ethanol 30%, DER 5–7.5:1 [Prospan® Cough Tablets]) under practice conditions. Adults and children aged 11–85 years of both genders were included. A total of 330 patients suffering from colds accompanied by coughing or from chronic, inflammatory bronchial diseases were scheduled to undergo treatment for a period of at least seven days. The tolerability of the tablets was rated by means of questionnaires.The results of this PMSS reflect the good to very good tolerability of the tablets in the global assess... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4725918 Thu, 06 Jan 2011 00:00:00 +0100 4725918 http://www.medworm.com/index.php?rid=4601820&cid=s_38427_13_f&fid=38427&url=http%3A%2F%2Fwww.phytomedicinejournal.com%2Farticle%2FPIIS0944711310004022%2Fabstract%3Frss%3Dyes Abstract: The incidence of obesity and related metabolic diseases is increasing globally. Current medical treatments often fail to halt the progress of such disturbances, and plant-derived polyphenols are increasingly being investigated as a possible way to provide safe and effective complementary therapy. Rooibos (Aspalathus linearis) is a rich source of polyphenols without caloric and/or stimulant components. We have tentatively characterized 25 phenolic compounds in rooibos extract and studied the effects of continuous aqueous rooibos extract consumption in mice. The effects of this extract, which contained 25% w/w of total polyphenol content, were negligible in animals with no metabolic disturbance but were significant in hyperlipemic mice, especially in those in which energy intake wa... Phytomedicine journals http://www.medworm.com/rss/comments.php?id=4601820 Thu, 06 Jan 2011 00:00:00 +0100 4601820